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4 results on '"Martin-Subero M"'

2. Quality of life in bipolar and schizoaffective disorder - A naturalistic approach

Author

Martin-Subero, M, Berk, L, Dodd, S, Kamalesh, V, Maes, M, Kulkarni, J, De Castella, A, Fitzgerald, PB, Berk, M, Martin-Subero, M, Berk, L, Dodd, S, Kamalesh, V, Maes, M, Kulkarni, J, De Castella, A, Fitzgerald, PB, and Berk, M

Abstract

PURPOSE: The aim of this study was to evaluate the health-related quality of life (HRQoL) in bipolar type I (BD I) and schizoaffective (SQA) patients during a 2-year period in a naturalistic study. METHODS: This study was based on the data generated by the Bipolar Comprehensive Outcome Study, a prospective, non-interventional, observational study of participants with BD I and SQA disorder. Mixed-Model Repeated Measures Analysis was used to analyze changes in the SF-36 and EQ-5D. RESULTS: Participants exhibited low health status at baseline with SF-36 mean scores of 46.7±10.5 and 36.9±12.9 (best imaginable health=100, normal population≈50) for physical and mental components, respectively. No significant differences were found between the ratings of the BD I and SQA patients on HRQoL. The SF-36 SMC improved significantly over 24 months although SPC scores remained consistent across the study. On the whole, the lowest SMC score was observed among the depressed patients (38.20), followed by the patients with a mixed state (39.01) and the manic patients (39.83). LIMITATIONS: The observational design may have limited the causal relationships and the generalizability within the current findings. CONCLUSIONS: HRQoL was significantly impaired in all stages of BD and SQA when compared to the general population. The impairment of HRQoL was most pronounced in the depressed state, followed by the mixed state and then the manic state. The euthymic patients showed the least impairment. In addition, patients showed a global improvement in their mental health satisfaction over the 2 years follow up period.

Published
2014

3. Brain imaging correlates of self- and other-reflection in schizophrenia.

Author

Fuentes-Claramonte P, Martin-Subero M, Salgado-Pineda P, Santo-Angles A, Argila-Plaza I, Salavert J, Arévalo A, Bosque C, Sarri C, Guerrero-Pedraza A, Capdevila A, Sarró S, McKenna PJ, Pomarol-Clotet E, and Salvador R

Subjects
Adult, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Self Concept, Social Cognition, Theory of Mind physiology, Young Adult, Brain physiopathology, Schizophrenia physiopathology, Schizophrenic Psychology
Abstract

Background: An alteration in self/other differentiation has been proposed as a basis for several symptoms in schizophrenia, including delusions of reference and social functioning deficits. Dysfunction of the right temporo-parietal junction (TPJ), a region linked with social cognition, has been proposed as the basis of this alteration. However, imaging studies of self- and other-processing in schizophrenia have shown, so far, inconsistent results., Methods: Patients with schizophrenia and healthy controls underwent fMRI scanning while performing a task with three conditions: self-reflection, other-reflection and semantic processing., Results: Both groups activated similar brain regions for self- and other-reflection compared to semantic processing, including the medial prefrontal cortex, the precuneus and the TPJ. Compared to healthy subjects, patients hyperactivated the left lateral frontal cortex during self- and other-reflection. In other-reflection, compared to self-reflection, patients failed to increase right TPJ activity., Conclusions: Altered activity in the right TPJ supports a disturbance in self/other differentiation in schizophrenia, which could be linked with psychotic symptoms and affect social functioning in patients. Hyperactivity of the lateral frontal cortex for self- and other-reflection suggests the presence of greater cognitive demand to perform the task in the patient group., Competing Interests: Declaration of Competing Interest None, (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2020
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4. Multiple adverse drug reactions and genetic polymorphism testing: A case report with negative result.

Author

Arellano AL, Martin-Subero M, Monerris M, LLerena A, Farré M, and Montané E

Subjects
Amines adverse effects, Amitriptyline adverse effects, Analgesics therapeutic use, Cyclohexanecarboxylic Acids adverse effects, Female, Gabapentin, Humans, Middle Aged, Polymorphism, Genetic, Syndrome, Thoracic Vertebrae, Tramadol adverse effects, gamma-Aminobutyric Acid adverse effects, Analgesics adverse effects, Drug Hypersensitivity genetics, Myelitis, Transverse drug therapy
Abstract

Rationale: Defects in drug metabolic pathways could explain why some patients have a history of multiple adverse drug reactions (ADR); therefore we aimed to analyze genetic polymorphisms in a patient with multiple ADR related to drugs with a common hepatic metabolic pathway through CYP2D6., Patient Concerns: We report a patient with psychosis and hypertension related to amitriptyline, tramadol, and duloxetine within a 2-year period., Interventions and Outcomes: A pharmacogenetic test was performed to assess the causative role of the CYP2D6 enzyme, but did not demonstrate a metabolic deficiency., Lessons: Although negative results in the reported case; typing for cytochrome P450 isoenzyme polymorphisms could be a useful diagnostic tool in some patients with a history of multiple ADR.

Published
2017
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