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1. Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)

Author

Schenk, Simon, Sagendorf, Tyler J, Many, Gina M, Lira, Ana K, de Sousa, Luis GO, Bae, Dam, Cicha, Michael, Kramer, Kyle S, Muehlbauer, Michael, Hevener, Andrea L, Rector, R Scott, Thyfault, John P, Williams, John P, Goodyear, Laurie J, Esser, Karyn A, Newgard, Christopher B, Bodine, Sue C, Adkins, Joshua N, Albertson, Brent G, Amar, David, Amper, Mary Anne S, Ashley, Euan, Bamman, Marcas M, Barnes, Jerry, Bergman, Bryan C, Bessesen, Daniel H, Buford, Thomas W, Burant, Charles F, Cutter, Gary R, De Sousa, Luis Gustavo Oliveria, Fernández, Facundo M, Gaul, David A, Ge, Yongchao, Goodpaster, Bret H, Guevara, Kristy, Hirshman, Michael F, Huffman, Kim M, Jackson, Bailey E, Jankowski, Catherine M, Jimenez-Morales, David, Kohrt, Wendy M, Kraus, William E, Lessard, Sarah J, Lester, Bridget, Lindholm, Malene E, Many, Gina, Marjanovic, Nada, Marshall, Andrea G, Melanson, Edward L, Miller, Michael E, Moreau, Kerrie L, Nair, Venugopalan D, Ortlund, Eric A, Qian, Wei-Jun, Rasmussen, Blake B, Richards, Collyn Z-T, Rushing, Scott, Sanford, James A, Schauer, Irene E, Schwartz, Robert S, Sealfon, Stuart C, Seenarine, Nitish, Sparks, Lauren M, Stowe, Cynthia L, Talton, Jennifer W, Teng, Christopher, Tesfa, Nathan D, Thalacker-Mercer, Anna, Trappe, Scott, Trappe, Todd A, Vasoya, Mital, Wheeler, Matthew T, Walkup, Michael P, Yan, Zhen, and Zhen, Jimmy

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Physical Activity, Cardiovascular, Prevention, Behavioral and Social Science, Animals, Male, Rats, Inbred F344, Female, Physical Conditioning, Animal, Adaptation, Physiological, Rats, Aging, Physical Endurance, Muscle, Skeletal, Endurance Training, training, treadmill, maximal oxygen uptake, body composition, citrate synthase, skeletal muscle, biorepository, aging, MoTrPAC Study Group, Medical physiology
Abstract

While regular physical activity is a cornerstone of health, wellness, and vitality, the impact of endurance exercise training on molecular signaling within and across tissues remains to be delineated. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to characterize molecular networks underlying the adaptive response to exercise. Here, we describe the endurance exercise training studies undertaken by the Preclinical Animal Sites Studies component of MoTrPAC, in which we sought to develop and implement a standardized endurance exercise protocol in a large cohort of rats. To this end, Adult (6-mo) and Aged (18-mo) female (n = 151) and male (n = 143) Fischer 344 rats were subjected to progressive treadmill training (5 d/wk, ∼70%-75% VO2max) for 1, 2, 4, or 8 wk; sedentary rats were studied as the control group. A total of 18 solid tissues, as well as blood, plasma, and feces, were collected to establish a publicly accessible biorepository and for extensive omics-based analyses by MoTrPAC. Treadmill training was highly effective, with robust improvements in skeletal muscle citrate synthase activity in as little as 1-2 wk and improvements in maximum run speed and maximal oxygen uptake by 4-8 wk. For body mass and composition, notable age- and sex-dependent responses were observed. This work in mature, treadmill-trained rats represents the most comprehensive and publicly accessible tissue biorepository, to date, and provides an unprecedented resource for studying temporal-, sex-, and age-specific responses to endurance exercise training in a preclinical rat model.

Published
2024

2. Temporal dynamics of the multi-omic response to endurance exercise training

Author

Bae, Dam, Dasari, Surendra, Dennis, Courtney, Evans, Charles R, Gaul, David A, Ilkayeva, Olga, Ivanova, Anna A, Kachman, Maureen T, Keshishian, Hasmik, Lanza, Ian R, Lira, Ana C, Muehlbauer, Michael J, Nair, Venugopalan D, Piehowski, Paul D, Rooney, Jessica L, Smith, Kevin S, Stowe, Cynthia L, Zhao, Bingqing, Clark, Natalie M, Jimenez-Morales, David, Lindholm, Malene E, Many, Gina M, Sanford, James A, Smith, Gregory R, Vetr, Nikolai G, Zhang, Tiantian, Almagro Armenteros, Jose J, Avila-Pacheco, Julian, Bararpour, Nasim, Ge, Yongchao, Hou, Zhenxin, Marwaha, Shruti, Presby, David M, Natarajan Raja, Archana, Savage, Evan M, Steep, Alec, Sun, Yifei, Wu, Si, Zhen, Jimmy, Bodine, Sue C, Esser, Karyn A, Goodyear, Laurie J, Schenk, Simon, Montgomery, Stephen B, Fernández, Facundo M, Sealfon, Stuart C, Snyder, Michael P, Adkins, Joshua N, Ashley, Euan, Burant, Charles F, Carr, Steven A, Clish, Clary B, Cutter, Gary, Gerszten, Robert E, Kraus, William E, Li, Jun Z, Miller, Michael E, Nair, K Sreekumaran, Newgard, Christopher, Ortlund, Eric A, Qian, Wei-Jun, Tracy, Russell, Walsh, Martin J, Wheeler, Matthew T, Dalton, Karen P, Hastie, Trevor, Hershman, Steven G, Samdarshi, Mihir, Teng, Christopher, Tibshirani, Rob, Cornell, Elaine, Gagne, Nicole, May, Sandy, Bouverat, Brian, Leeuwenburgh, Christiaan, Lu, Ching-ju, Pahor, Marco, Hsu, Fang-Chi, Rushing, Scott, Walkup, Michael P, Nicklas, Barbara, Rejeski, W Jack, Williams, John P, Xia, Ashley, Albertson, Brent G, Barton, Elisabeth R, Booth, Frank W, Caputo, Tiziana, Cicha, Michael, De Sousa, Luis Gustavo Oliveira, Farrar, Roger, Hevener, Andrea L, Hirshman, Michael F, Jackson, Bailey E, Ke, Benjamin G, Kramer, Kyle S, Lessard, Sarah J, Makarewicz, Nathan S, Marshall, Andrea G, and Nigro, Pasquale

Subjects
Health Sciences, Sports Science and Exercise, Prevention, Human Genome, Cardiovascular, Behavioral and Social Science, Genetics, Physical Activity, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Generic health relevance, Inflammatory and immune system, Good Health and Well Being, Animals, Female, Humans, Male, Rats, Acetylation, Blood, Cardiovascular Diseases, Databases, Factual, Endurance Training, Epigenome, Inflammatory Bowel Diseases, Internet, Lipidomics, Metabolome, Mitochondria, Multiomics, Non-alcoholic Fatty Liver Disease, Organ Specificity, Phosphorylation, Physical Conditioning, Animal, Physical Endurance, Proteome, Proteomics, Time Factors, Transcriptome, Ubiquitination, Wounds and Injuries, MoTrPAC Study Group, Lead Analysts, MoTrPAC Study Group, General Science & Technology
Abstract

Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood1-3. Here, the Molecular Transducers of Physical Activity Consortium4 profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository ( https://motrpac-data.org/ ).

Published
2024

3. Diversity, Equity and Inclusion in the Laboratory: Strategies to Enhance Inclusive Laboratory Culture

Author

Marshall, Andrea G, Vue, Zer, Beasley, Heather K, Neikirk, Kit, Stephens, Dominique, Wanjalla, Celestine N, Damo, Steven M, Trejo, JoAnn, Rodriguez-Aliaga, Piere, Headley, Colwyn Ansel, Shuler, Haysetta, Liu, Kaihua, Smith, Nathan, Garza-Lopez, Edgar, Barongan, Taylor, Scudese, Estevão, Spencer, Elsie, Heemstra, Jennifer, Vazquez, Arnaldo Diaz, Murray, Sandra A, and Hinton, Antentor

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Health Sciences, Diversity, Equity, Inclusion, Laboratories, DEI, cultural competency, cultural humility, laboratory, leadership, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Building a diverse laboratory that is equitable is critical for the retention of talent and the growth of trainees professionally and personally. Here, we outline several strategies including enhancing understanding of cultural competency and humility, establishing laboratory values, and developing equitable laboratory structures to create an inclusive laboratory environment to enable trainees to achieve their highest success.

Published
2023

4. Optimising the diagnostic accuracy of First post-contrAst SubtracTed breast MRI (FAST MRI) through interpretation-training: a multicentre e-learning study, mapping the learning curve of NHS Breast Screening Programme (NHSBSP) mammogram readers using an enriched dataset

Author

Jones, Lyn I., Marshall, Andrea, Geach, Rebecca, Elangovan, Premkumar, O’Flynn, Elizabeth, Timlin, Tony, McKeown-Keegan, Sadie, Rose, Janice, Vinnicombe, Sarah, Taylor-Phillips, Sian, Halling-Brown, Mark, and Dunn, Janet A.

Published
2024
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6. Juneteenth in STEMM and the barriers to equitable science

Author

Mays, Alfred, Byars-Winston, Angela, Hinton, Antentor, Marshall, Andrea G, Kirabo, Annet, August, Avery, Marlin, Bianca J, Riggs, Blake, Tolbert, Blanton, Wanjalla, Celestine, Womack, Chad, Evans, Chantell S, Barnes, Christopher, Starbird, Chrystal, Williams, Clintoria, Reynolds, Corey, Taabazuing, Cornelius, Cameron, Craig E, Murray, Debra D, Applewhite, Derek, Morton, Derrick J, Lee, Dexter, Williams, Dionna W, Lynch, Donald, Brady, Donita, Lynch, Erin, Rutaganira, Florentine UN, Silva, Gustavo M, Shuler, Haysetta, Saboor, Ishmail Abdus, Davis, Jamaine, Dzirasa, Kafui, Hammonds-Odie, Latanya, Reyes, Loretta, Sweetwyne, Mariya T, McReynolds, Melanie R, Johnson, Michael DL, Smith, Nathan A, Pittman, Nikea, Ajijola, Olujimi A, Smith, Quinton, Robinson, Renã AS, Lewis, Samantha C, Murray, Sandra A, Black, Sherilynn, Neal, Sonya E, Andrisse, Stanley, Townsend, Steven, Damo, Steven M, Griffith, Theanne N, Lambert, W Marcus, and Clemons, William M

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Humans, Black People, Juneteenth, STEMM, diversity, scientific racism, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

We are 52 Black scientists. Here, we establish the context of Juneteenth in STEMM and discuss the barriers Black scientists face, the struggles they endure, and the lack of recognition they receive. We review racism's history in science and provide institutional-level solutions to reduce the burdens on Black scientists.

Published
2023

7. The ketogenic diet preserves skeletal muscle with aging in mice

Author

Wallace, Marita A, Aguirre, Nicholas W, Marcotte, George R, Marshall, Andrea G, Baehr, Leslie M, Hughes, David C, Hamilton, Karyn L, Roberts, Megan N, Lopez‐Dominguez, Jose Alberto, Miller, Benjamin F, Ramsey, Jon J, and Baar, Keith

Subjects
Biochemistry and Cell Biology, Biological Sciences, Aging, Nutrition, Complementary and Integrative Health, 1.1 Normal biological development and functioning, Underpinning research, Musculoskeletal, Animals, Antioxidants, Diet, Ketogenic, Endoplasmic Reticulum Stress, Male, Mice, Mice, Inbred C57BL, Mitochondria, Muscle, Muscle, Skeletal, Neuromuscular Junction, Organelle Biogenesis, Oxidation-Reduction, Oxidative Stress, Proteasome Endopeptidase Complex, Protein Biosynthesis, Sarcopenia, Signal Transduction, aging, ketogenic diet, mice, sarcopenia, skeletal muscle, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

The causes of the decline in skeletal muscle mass and function with age, known as sarcopenia, are poorly understood. Nutrition (calorie restriction) interventions impact many cellular processes and increase lifespan and preserve muscle mass and function with age. As we previously observed an increase in life span and muscle function in aging mice on a ketogenic diet (KD), we aimed to investigate the effect of a KD on the maintenance of skeletal muscle mass with age and the potential molecular mechanisms of this action. Twelve-month-old mice were assigned to an isocaloric control or KD until 16 or 26 months of age, at which time skeletal muscle was collected for evaluating mass, morphology, and biochemical properties. Skeletal muscle mass was significantly greater at 26 months in the gastrocnemius of mice on the KD. This result in KD mice was associated with a shift in fiber type from type IIb to IIa fibers and a range of molecular parameters including increased markers of NMJ remodeling, mitochondrial biogenesis, oxidative metabolism, and antioxidant capacity, while decreasing endoplasmic reticulum (ER) stress, protein synthesis, and proteasome activity. Overall, this study shows the effectiveness of a long-term KD in mitigating sarcopenia. The diet preferentially preserved oxidative muscle fibers and improved mitochondrial and antioxidant capacity. These adaptations may result in a healthier cellular environment, decreasing oxidative and ER stress resulting in less protein turnover. These shifts allow mice to better maintain muscle mass and function with age.

Published
2021

8. Evaluating the effectiveness of abbreviated breast MRI (abMRI) interpretation training for mammogram readers: a multi-centre study assessing diagnostic performance, using an enriched dataset

Author

Jones, Lyn I., Marshall, Andrea, Elangovan, Premkumar, Geach, Rebecca, McKeown-Keegan, Sadie, Vinnicombe, Sarah, Harding, Sam A., Taylor-Phillips, Sian, Halling-Brown, Mark, Foy, Christopher, O’Flynn, Elizabeth, Ghiasvand, Hesam, Hulme, Claire, and Dunn, Janet A.

Published
2022
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9. Improving partnerships with family members of ICU patients: study protocol for a randomized controlled trial

Author

Heyland, Daren K, Davidson, Judy, Skrobik, Yoanna, des Ordons, Amanda Roze, Van Scoy, Lauren J, Day, Andrew G, Vandall-Walker, Virginia, and Marshall, Andrea P

Subjects
Patient and family engagement, Randomized trial, Nutrition, End of life, decision-making, Supportive care, Critical care
Abstract

BackgroundOver the last decade, health care delivery has shifted to partnering with patients and their families to improve health and quality of care, and to lower costs. Partnering with family members (FMs) of critically ill patients who lack capacity is particularly important for improving experiences and outcomes for both patients and FMs. How best to apply such partnering strategies, however, is yet unknown. The IMPACT trial will evaluate two interventions that enable partnerships with families of critically ill patients, each in a distinct content area, but similar in that they empower and support FMs.MethodsThis multi-center, open-label, randomized, phase II clinical trial aims to randomize 150 older, long-stay ICU patients and their families into one of three groups (50 in each group): (1) The OPTimal nutrition by Informing and Capacitating FMs of best practices (OPTICs) group, a multi-faceted intervention to engage and empower FMs to advocate for, and audit, best nutritional practices for their critically ill FMs, (2) A web-based decision-support intervention called the ICU Workbook (The Canadian Researchers at the End of Life Network (CARENET) ICU Workbook; https://www.myicuguide.ca/. Accessed 3 Feb 2017.) to support families in shared decision-making process regarding goals of medical treatments, and (3) Usual care. The main outcomes for this trial include nutritional adequacy in hospital and hand-grip strength prior to hospital discharge; satisfaction with decision-making; decision conflict; and degree of shared decision-making.DiscussionWith the goal of improving the functional recovery of nutritionally high-risk older patients and the quality of care at the end of life for these patients and their FMs in the ICU, we have proposed two novel family capacitation strategies. We hope that the nutrition and decision-support interventions implemented and evaluated in our study will contribute to the evidentiary basis for best family partnered care pathways focused on optimizing the quality of ICU care for patients with life-threatening illness and their families.Trial registrationClinical trials.gov, ID: NCT02920086. Registered on 30 September 2016. Protocol version dated 11 October 2016.

Published
2018

10. Research Priorities to Support Effective Manta and Devil Ray Conservation

Author

Stewart, Joshua D, Jaine, Fabrice RA, Armstrong, Amelia J, Armstrong, Asia O, Bennett, Michael B, Burgess, Katherine B, Couturier, Lydie IE, Croll, Donald A, Cronin, Melissa R, Deakos, Mark H, Dudgeon, Christine L, Fernando, Daniel, Froman, Niv, Germanov, Elitza S, Hall, Martin A, Hinojosa-Alvarez, Silvia, Hosegood, Jane E, Kashiwagi, Tom, Laglbauer, Betty JL, Lezama-Ochoa, Nerea, Marshall, Andrea D, McGregor, Frazer, di Sciara, Giuseppe Notarbartolo, Palacios, Marta D, Peel, Lauren R, Richardson, Anthony J, Rubin, Robert D, Townsend, Kathy A, Venables, Stephanie K, and Stevens, Guy MW

Subjects
Biological Sciences, Ecology, Life on Land, manta, mobula, devil ray, elasmobranch, management, Oceanography, Geology
Published
2018

12. Age-related Differences in Dystrophin: Impact on Force Transfer Proteins, Membrane Integrity, and Neuromuscular Junction Stability

Author

Hughes, David C, Marcotte, George R, Marshall, Andrea G, West, Daniel WD, Baehr, Leslie M, Wallace, Marita A, Saleh, Perrie M, Bodine, Sue C, and Baar, Keith

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Aging, Muscular Dystrophy, Brain Disorders, Intellectual and Developmental Disabilities (IDD), Rare Diseases, Musculoskeletal, Animals, Blotting, Western, Dystrophin, Electric Stimulation, Immunohistochemistry, Muscle Contraction, Muscle Proteins, Muscle, Skeletal, Neuromuscular Junction, Neuromuscular Junction Diseases, RNA, Rats, Rats, Inbred F344, Force transmission, Skeletal muscle, Dystrophin-associated glycoprotein complex, Regeneration, Clinical Sciences, Gerontology, Biomedical and clinical sciences, Health sciences
Abstract

The loss of muscle strength with age has been studied from the perspective of a decline in muscle mass and neuromuscular junction (NMJ) stability. A third potential factor is force transmission. The purpose of this study was to determine the changes in the force transfer apparatus within aging muscle and the impact on membrane integrity and NMJ stability. We measured an age-related loss of dystrophin protein that was greatest in the flexor muscles. The loss of dystrophin protein occurred despite a twofold increase in dystrophin mRNA. Importantly, this disparity could be explained by the four- to fivefold upregulation of the dystromir miR-31. To compensate for the loss of dystrophin protein, aged muscle contained increased α-sarcoglycan, syntrophin, sarcospan, laminin, β1-integrin, desmuslin, and the Z-line proteins α-actinin and desmin. In spite of the adaptive increase in other force transfer proteins, over the 48 hours following lengthening contractions, the old muscles showed more signs of impaired membrane integrity (fourfold increase in immunoglobulin G-positive fibers and 70% greater dysferlin mRNA) and NMJ instability (14- to 96-fold increases in Runx1, AchRδ, and myogenin mRNA). Overall, these data suggest that age-dependent alterations in dystrophin leave the muscle membrane and NMJ more susceptible to contraction-induced damage even before changes in muscle mass are obvious.

Published
2017

13. Recommendations for the College of Intensive Care Medicine (CICM) trainee research project: A modified Delphi study

Author

Ho, Ariel, Denny, Kerina J., Laupland, Kevin B., Ramanan, Mahesh, Tabah, Alexis, McCullough, James, Schults, Jessica A., Raman, Sainath, Apte, Yogesh, Attokaran, Antony, Baker, Stuart, Bartholdy, Roland, Bhadange, Neeraj, Brailsford, Jane, Cook, Katrina, David, Alexandre, Dhanani, Jayesh, Edwards, Felicity, Elkady, Hatem, Evans, Tess, Hutchinson, Jane, Lannon, Sean, Marshall, Andrea, McIlroy, Philippa, Milford, Elissa, Morrison, Lynette, Murray, Lauren, Serratore, Alyssa, Shah, Vikram, Shekar, Kiran, Watts, Stacey, and White, Kyle

Abstract

To determine the perceived barriers and enablers to efficient completion of the College of Intensive Care Medicine (CICM) of Australia and New Zealand Formal Project – a trainee research project mandated for award of CICM Fellowship – and to develop consensus-based recommendations to support Intensive Care trainees and supervisors.

Published
2024
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15. Half a century of global decline in oceanic sharks and rays

Author

Pacoureau, Nathan, Rigby, Cassandra L., Kyne, Peter M., Sherley, Richard B., Winker, Henning, Carlson, John K., Fordham, Sonja V., Barreto, Rodrigo, Fernando, Daniel, Francis, Malcolm P., Jabado, Rima W., Herman, Katelyn B., Liu, Kwang-Ming, Marshall, Andrea D., Pollom, Riley A., Romanov, Evgeny V., Simpfendorfer, Colin A., Yin, Jamie S., Kindsvater, Holly K., and Dulvy, Nicholas K.

Published
2021
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16. Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis

Author

Baehr, Leslie M, West, Daniel WD, Marcotte, George, Marshall, Andrea G, De Sousa, Luis Gustavo, Baar, Keith, and Bodine, Sue C

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Aging, Aetiology, 2.1 Biological and endogenous factors, Musculoskeletal, Age Factors, Animals, Autophagy, Disease Models, Animal, Endoplasmic Reticulum, Endoplasmic Reticulum Stress, Gene Expression Regulation, Hindlimb Suspension, Male, Muscle Proteins, Muscle Strength, Muscle, Skeletal, Muscular Atrophy, Proteasome Endopeptidase Complex, Protein Biosynthesis, Proteolysis, Rats, Inbred F344, Recovery of Function, Time Factors, aging, hindlimb unloading, anabolic resistance, ubiquitin proteasome system, autophagy, Biochemistry and cell biology, Clinical sciences
Abstract

Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and strength in old rats following disuse-induced atrophy. Adult (9 month) and old (29 month) male F344BN rats underwent hindlimb unloading (HU) followed by reloading. HU induced significant atrophy of the hindlimb muscles in both adult (17-38%) and old (8-29%) rats, but only the adult rats exhibited full recovery of muscle mass and strength upon reloading. Upon reloading, total RNA and protein synthesis increased to a similar extent in adult and old muscles. At baseline and upon reloading, however, proteasome-mediated degradation was suppressed leading to an accumulation of ubiquitin-tagged proteins and p62. Further, ER stress, as measured by CHOP expression, was elevated at baseline and upon reloading in old rats. Analysis of mRNA expression revealed increases in HDAC4, Runx1, myogenin, Gadd45a, and the AChRs in old rats, suggesting neuromuscular junction instability/denervation. Collectively, our data suggests that with aging, impaired neuromuscular transmission and deficits in the proteostasis network contribute to defects in muscle fiber remodeling and functional recovery of muscle mass and strength.

Published
2016

20. Global status and conservation potential of reef sharks

Author

MacNeil, M. Aaron, Chapman, Demian D., Heupel, Michelle, Simpfendorfer, Colin A., Heithaus, Michael, Meekan, Mark, Harvey, Euan, Goetze, Jordan, Kiszka, Jeremy, Bond, Mark E., Currey-Randall, Leanne M., Speed, Conrad W., Sherman, C. Samantha, Rees, Matthew J., Udyawer, Vinay, Flowers, Kathryn I., Clementi, Gina, Valentin-Albanese, Jasmine, Gorham, Taylor, Adam, M. Shiham, Ali, Khadeeja, Pina-Amargós, Fabián, Angulo-Valdés, Jorge A., Asher, Jacob, Barcia, Laura García, Beaufort, Océane, Benjamin, Cecilie, Bernard, Anthony T. F., Berumen, Michael L., Bierwagen, Stacy, Bonnema, Erika, Bown, Rosalind M. K., Bradley, Darcy, Brooks, Edd, Brown, J. Jed, Buddo, Dayne, Burke, Patrick, Cáceres, Camila, Cardeñosa, Diego, Carrier, Jeffrey C., Caselle, Jennifer E., Charloo, Venkatesh, Claverie, Thomas, Clua, Eric, Cochran, Jesse E. M., Cook, Neil, Cramp, Jessica, D’Alberto, Brooke, de Graaf, Martin, Dornhege, Mareike, Estep, Andy, Fanovich, Lanya, Farabaugh, Naomi F., Fernando, Daniel, Flam, Anna L., Floros, Camilla, Fourqurean, Virginia, Garla, Ricardo, Gastrich, Kirk, George, Lachlan, Graham, Rory, Guttridge, Tristan, Hardenstine, Royale S., Heck, Stephen, Henderson, Aaron C., Hertler, Heidi, Hueter, Robert, Johnson, Mohini, Jupiter, Stacy, Kasana, Devanshi, Kessel, Steven T., Kiilu, Benedict, Kirata, Taratu, Kuguru, Baraka, Kyne, Fabian, Langlois, Tim, Lédée, Elodie J. I., Lindfield, Steve, Luna-Acosta, Andrea, Maggs, Jade, Manjaji-Matsumoto, B. Mabel, Marshall, Andrea, Matich, Philip, McCombs, Erin, McLean, Dianne, Meggs, Llewelyn, Moore, Stephen, Mukherji, Sushmita, Murray, Ryan, Kaimuddin, Muslimin, Newman, Stephen J., Nogués, Josep, Obota, Clay, O’Shea, Owen, Osuka, Kennedy, Papastamatiou, Yannis P., Perera, Nishan, Peterson, Bradley, Ponzo, Alessandro, Prasetyo, Andhika, Quamar, L. M. Sjamsul, Quinlan, Jessica, Ruiz-Abierno, Alexei, Sala, Enric, Samoilys, Melita, Schärer-Umpierre, Michelle, Schlaff, Audrey, Simpson, Nikola, Smith, Adam N. H., Sparks, Lauren, Tanna, Akshay, Torres, Rubén, Travers, Michael J., van Zinnicq Bergmann, Maurits, Vigliola, Laurent, Ward, Juney, Watts, Alexandra M., Wen, Colin, Whitman, Elizabeth, Wirsing, Aaron J., Wothke, Aljoscha, Zarza-Gonzâlez, Esteban, and Cinner, Joshua E.

Published
2020
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21. FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer

Author

Annett, Stephanie, Moore, Gillian, Short, Amy, Marshall, Andrea, McCrudden, Cian, Yakkundi, Anita, Das, Sudipto, McCluggage, W. Glenn, Nelson, Laura, Harley, Ian, Moustafa, Nermeen, Kennedy, Catherine J., deFazio, Anna, Brand, Alison, Sharma, Raghwa, Brennan, Donal, O’Toole, Sharon, O’Leary, John, Bates, Mark, O’Riain, Ciarán, O’Connor, Darran, Furlong, Fiona, McCarthy, Helen, Kissenpfennig, Adrien, McClements, Lana, and Robson, Tracy

Published
2020
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25. Considerations for Developing Mitochondrial Transplantation Techniques for Individualized Medicine

Author

Neikirk, Kit, Stephens, Dominique C, Beasley, Heather K, Marshall, Andrea G, Gaddy, Jennifer A, Damo, Steven M, and Hinton, Antentor O

Abstract

Tweetable abstractMitochondrial transplantation has been used to treat various diseases associated with mitochondrial dysfunction. Here, we highlight the considerations in quality control mechanisms that should be considered in the context of mitochondrial transplantation.

Published
2024
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30. Is Space the Final Frontier for Mitochondrial Study?

Author

Neikirk, Kit, Stephens, Dominique C, Beasley, Heather K, Marshall, Andrea G, Gaddy, Jennifer A, Damo, Steven M, and Hinton, Antentor

Abstract

Tweetable abstractThis perspective considers several avenues for future research on mitochondrial dynamics, stress, and DNA in outer space.

Published
2024
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34. Author Correction: Global status and conservation potential of reef sharks

Author

MacNeil, M. Aaron, Chapman, Demian D., Heupel, Michelle, Simpfendorfer, Colin A., Heithaus, Michael, Meekan, Mark, Harvey, Euan, Goetze, Jordan, Kiszka, Jeremy, Bond, Mark E., Currey-Randall, Leanne M., Speed, Conrad W., Sherman, C. Samantha, Rees, Matthew J., Udyawer, Vinay, Flowers, Kathryn I., Clementi, Gina, Valentin-Albanese, Jasmine, Gorham, Taylor, Adam, M. Shiham, Ali, Khadeeja, Pina-Amargós, Fabián, Angulo-Valdés, Jorge A., Asher, Jacob, Barcia, Laura García, Beaufort, Océane, Benjamin, Cecilie, Bernard, Anthony T. F., Berumen, Michael L., Bierwagen, Stacy, Bonnema, Erika, Bown, Rosalind M. K., Bradley, Darcy, Brooks, Edd, Brown, J. Jed, Buddo, Dayne, Burke, Patrick, Cáceres, Camila, Cardeñosa, Diego, Carrier, Jeffrey C., Caselle, Jennifer E., Charloo, Venkatesh, Claverie, Thomas, Clua, Eric, Cochran, Jesse E. M., Cook, Neil, Cramp, Jessica, D’Alberto, Brooke, de Graaf, Martin, Dornhege, Mareike, Estep, Andy, Fanovich, Lanya, Farabaugh, Naomi F., Fernando, Daniel, Flam, Anna L., Floros, Camilla, Fourqurean, Virginia, Garla, Ricardo, Gastrich, Kirk, George, Lachlan, Graham, Rory, Guttridge, Tristan, Hardenstine, Royale S., Heck, Stephen, Henderson, Aaron C., Hertler, Heidi, Hueter, Robert, Johnson, Mohini, Jupiter, Stacy, Kasana, Devanshi, Kessel, Steven T., Kiilu, Benedict, Kirata, Taratu, Kuguru, Baraka, Kyne, Fabian, Langlois, Tim, Lédée, Elodie J. I., Lindfield, Steve, Luna-Acosta, Andrea, Maggs, Jade, Manjaji-Matsumoto, B. Mabel, Marshall, Andrea, Matich, Philip, McCombs, Erin, McLean, Dianne, Meggs, Llewelyn, Moore, Stephen, Mukherji, Sushmita, Murray, Ryan, Kaimuddin, Muslimin, Newman, Stephen J., Nogués, Josep, Obota, Clay, O’Shea, Owen, Osuka, Kennedy, Papastamatiou, Yannis P., Perera, Nishan, Peterson, Bradley, Ponzo, Alessandro, Prasetyo, Andhika, Quamar, L. M. Sjamsul, Quinlan, Jessica, Ruiz-Abierno, Alexei, Sala, Enric, Samoilys, Melita, Schärer-Umpierre, Michelle, Schlaff, Audrey, Simpson, Nikola, Smith, Adam N. H., Sparks, Lauren, Tanna, Akshay, Torres, Rubén, Travers, Michael J., van Zinnicq Bergmann, Maurits, Vigliola, Laurent, Ward, Juney, Watts, Alexandra M., Wen, Colin, Whitman, Elizabeth, Wirsing, Aaron J., Wothke, Aljoscha, Zarza-Gonzâlez, Esteban, and Cinner, Joshua E.

Published
2020
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40. Methodological Rigor and Transparency in Clinical Practice Guidelines for Nutrition Care in Critically Ill Adults: A Systematic Review Using the AGREE II and AGREE-REX Tools

Author

Noyahr, John K., primary, Tatucu-Babet, Oana A., additional, Chapple, Lee-anne S., additional, Barlow, Christopher Jake, additional, Chapman, Marianne J., additional, Deane, Adam M., additional, Fetterplace, Kate, additional, Hodgson, Carol L., additional, Winderlich, Jacinta, additional, Udy, Andrew A., additional, Marshall, Andrea P., additional, and Ridley, Emma J., additional

Published
2022
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50. Pressure injury prevention practices among medical surgical nurses in a tertiary hospital: An observational and chart audit study.

Author

Li, Zhaoyu, Marshall, Andrea P, Lin, Frances, Ding, Yanming, and Chaboyer, Wendy

Subjects
OCCUPATIONAL roles, AUDITING, SCIENTIFIC observation, PRESSURE ulcers, SKIN care, TERTIARY care, MEDICAL screening, NURSING practice, T-test (Statistics), RISK assessment, NURSES, HOSPITAL wards, CHI-squared test, MEDICAL-surgical nurses, PATIENT positioning
Abstract

Pressure injuries are frequently occurring adverse events in hospitals, negatively impacting patient safety and quality of care. Most pressure injuries are avoidable if effective prevention strategies are used. However, the extent to which various settings influence their use of prevention strategies is unknown. The aim of this study was to describe and compare pressure injury prevention strategies used by medical and surgical nurses in the Chinese context. In this observational study, we used semi‐structured observations with chart audits to collect data in two medical and two surgical wards in a tertiary hospital from June to December 2020. Observations were patient‐focused; any prevention practices the patient received were recorded, and a chart audit was used to identify documented prevention strategies. The frequency of each prevention strategy was reported, and differences between medical and surgical wards were analysed using independent t‐test or χ2 test. A total of 577 patients (n = 294, 50.9% medical; n = 283, 49.1% surgical) were observed and their charts audited. Risk assessment was completed on admission for all patients. Repositioning was the most frequently used strategy, with about 84% (n = 486) patients being repositioned regularly. However, skin care, nutritional risk screening and the use of support surfaces were suboptimal. Patient education was not commonly observed but was documented in 75% (n = 433) of audited charts. More medical patients' skin was kept clean and hydrated, but more surgical patients received barrier creams, had a support surface and received more nutrition support and if a prone position was used, they were more likely to be turned after 2 hr and to be repositioned after sitting in a chair for an hour. Prevention strategies were more likely to be documented in surgical patients' charts. Despite pressure injury prevention guideline recommendations provided various prevention strategies for nurses to apply, the observed use of some strategies such as nutrition, skin care and support surfaces was not ideal. Nurses relied heavily on repositioning for pressure injury prevention. Most pressure injury prevention practices need improvement although surgical patients generally received better preventative care. These findings can facilitate clinicians and nurse managers when tailoring future pressure injury prevention work. [ABSTRACT FROM AUTHOR]

Published
2022
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