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1. Dynamic Prediction of Advanced Colorectal Neoplasia in Inflammatory Bowel Disease

Author

van Bodegraven, Adriaan A., Fidder, Herma H., Hirdes, Meike M.C., Hoentjen, Frank, Jansen, Jeroen M., Mahmmod, Nofel, van der Meulen-de Jong, Andrea E., Ponsioen, Cyriel Y., van Schaik, Fiona D.M., van der Woude, C. Janneke, Wijnands, Anouk M., Penning de Vries, Bas B.L., Lutgens, Maurice W.M.D., Bakhshi, Zeinab, Al Bakir, Ibrahim, Beaugerie, Laurent, Bernstein, Charles N., Chang-ho Choi, Ryan, Coelho-Prabhu, Nayantara, Graham, Trevor A., Hart, Ailsa L., ten Hove, Joren R., Itzkowitz, Steven H., Kirchgesner, Julien, Mooiweer, Erik, Shaffer, Seth R., Shah, Shailja C., Elias, Sjoerd G., and Oldenburg, Bas

Published
2024
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2. Complete Endoscopic Healing Is Associated With Lower Relapse Risk After Anti-TNF Withdrawal in Inflammatory Bowel Disease

Author

Mahmoud, Remi, Savelkoul, Edo H.J., Mares, Wout, Goetgebuer, Rogier, Witteman, Ben J.M., de Koning, Daan B., van Tuyl, Sebastiaan A.C., Minderhoud, Itta, Lutgens, Maurice W.M. D., Akol-Simsek, Dilek, van Schaik, Fiona D.M., Fidder, Herma H., Jansen, Jeroen M., van Boeckel, Petra G.A., Mahmmod, Nofel, Horjus-Talabur Horje, Carmen S., Römkens, Tessa E.H., Colombel, Jean-Frédéric, Hoentjen, Frank, Jharap, Bindia, and Oldenburg, Bas

Published
2023
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4. Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients

Author

Oldenburg, Bas, van Wijk, Femke, Brand, Eelco C., Honkoop, Pieter, Jacobs, Rutger J., Ponsioen, Cyriel Y., de Boer, Nanne K.H., Alderlieste, Yasser A., van Herwaarden, Margot A., van Tuyl, Sebastiaan A.C., Lutgens, Maurice W., Janneke van der Woude, C., Mares, Wout G.M., de Koning, Daan B., Bosman, Joukje H., Vecht, Juda, de Schryver, Anneke M.P., van der Meulen-de Jong, Andrea E., Pierik, Marieke J., Boekema, Paul J., Verburg, Robert J., Jharap, Bindia, Willemsen, Gonneke, Boomsma, Dorret I., Jansen, Jeroen M., Stokkers, Pieter C.F., Hoentjen, Frank, Quispel, Rutger, Horjus Talabur Horje, Carmen S., van de Meeberg, Paul C., Mahmmod, Nofel, West, Rachel L., Willems, Marleen, Minderhoud, Itta M., Fidder, Herma H., van Schaik, Fiona D.M., Hirdes, Meike M.C., Boontje, Nynke A., Müskens, Bart L.M., Weersma, Rinse K., Romberg-Camps, Marielle J.L., Klaassen, Marjolein A.Y., Gacesa, Ranko, Vich Vila, Arnau, Ghosh, Hiren, de Zoete, Marcel R., Fu, Jingyuan, Wijmenga, Cisca, and Zhernakova, Alexandra

Published
2021
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6. Methotrexate accumulation in target intestinal mucosa and white blood cells differs from non-target red blood cells of patients with Crohn's disease

Author

Unit Opleiding MDL, Genetica Sectie Metabole Diagnostiek, MS MDL 1, Cancer, Infection & Immunity, van de Meeberg, Maartje M, Sundaresan, Janani, Lin, Marry, Jansen, Gerrit, Struys, Eduard A, Fidder, Herma H, Oldenburg, Bas, Mares, Wout G N, Mahmmod, Nofel, van Asseldonk, Dirk P, Rietdijk, Svend T, Nissen, Loes H C, de Boer, Nanne K H, Bouma, Gerd, Ćalasan, Maja Bulatović, de Jonge, Robert, On behalf on the Dutch Initiative on Crohn and Colitis (ICC), Unit Opleiding MDL, Genetica Sectie Metabole Diagnostiek, MS MDL 1, Cancer, Infection & Immunity, van de Meeberg, Maartje M, Sundaresan, Janani, Lin, Marry, Jansen, Gerrit, Struys, Eduard A, Fidder, Herma H, Oldenburg, Bas, Mares, Wout G N, Mahmmod, Nofel, van Asseldonk, Dirk P, Rietdijk, Svend T, Nissen, Loes H C, de Boer, Nanne K H, Bouma, Gerd, Ćalasan, Maja Bulatović, de Jonge, Robert, and On behalf on the Dutch Initiative on Crohn and Colitis (ICC)

Published
2024

7. Dynamic Prediction of Advanced Colorectal Neoplasia in Inflammatory Bowel Disease

Author

Wijnands, Anouk M., primary, Penning de Vries, Bas B.L., additional, Lutgens, Maurice W.M.D., additional, Bakhshi, Zeinab, additional, Al Bakir, Ibrahim, additional, Beaugerie, Laurent, additional, Bernstein, Charles N., additional, Chang-ho Choi, Ryan, additional, Coelho-Prabhu, Nayantara, additional, Graham, Trevor A., additional, Hart, Ailsa L., additional, ten Hove, Joren R., additional, Itzkowitz, Steven H., additional, Kirchgesner, Julien, additional, Mooiweer, Erik, additional, Shaffer, Seth R., additional, Shah, Shailja C., additional, Elias, Sjoerd G., additional, Oldenburg, Bas, additional, van Bodegraven, Adriaan A., additional, Fidder, Herma H., additional, Hirdes, Meike M.C., additional, Hoentjen, Frank, additional, Jansen, Jeroen M., additional, Mahmmod, Nofel, additional, van der Meulen-de Jong, Andrea E., additional, Ponsioen, Cyriel Y., additional, van Schaik, Fiona D.M., additional, and van der Woude, C. Janneke, additional

Published
2024
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8. High Risk of Advanced Colorectal Neoplasia in Patients With Primary Sclerosing Cholangitis Associated With Inflammatory Bowel Disease

Author

Shah, Shailja C., ten Hove, Joren R., Castaneda, Daniel, Palmela, Carolina, Mooiweer, Erik, Colombel, Jean-Frédéric, Harpaz, Noam, Ullman, Thomas A., van Bodegraven, Ad A., Jansen, Jeroen M., Mahmmod, Nofel, van der Meulen-de Jong, Andrea E., Ponsioen, Cyriel Y., van der Woude, Christine J., Oldenburg, Bas, Itzkowitz, Steven H., and Torres, Joana

Published
2018
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9. Therapeutic drug monitoring of methotrexate in patients with Crohn's disease.

Author

van de Meeberg, Maartje M., Fidder, Herma H., Oldenburg, Bas, Sundaresan, Janani, Struys, Eduard A., Montazeri, Nahid S. M., Mares, Wout G. N., Mahmmod, Nofel, van Asseldonk, Dirk P., Lutgens, Maurice W. M. D., Kuyvenhoven, Johan P., Rietdijk, Svend T., Nissen, Loes H. C., Koehestanie, Parweez, de Boer, Nanne K. H., de Jonge, Robert, Bouma, Gerd, Bulatović Ćalasan, Maja, van Schaik, Fiona, and van der Horst, Inge

Subjects
CROHN'S disease, DRUG monitoring, PATIENT monitoring, TERMINATION of treatment, METHOTREXATE
Abstract

Summary: Background: Therapeutic drug monitoring (TDM) has the potential to improve efficacy and diminish side effects. Measuring methotrexate‐polyglutamate (MTX‐PG) in erythrocytes might enable TDM for methotrexate in patients with Crohn's disease (CD). Aim: To investigate the relationship between MTX‐PGs and methotrexate drug survival, efficacy and toxicity Methods: In a multicentre prospective cohort study, patients with CD starting subcutaneous methotrexate without biologics were included and followed for 12 months. Primary outcome was subcutaneous methotrexate discontinuation or requirement for step‐up therapy. Secondary outcomes included faecal calprotectin (FCP), Harvey Bradshaw Index (HBI), hepatotoxicity and gastrointestinal intolerance. Erythrocyte MTX‐PGs were analysed at weeks 8, 12, 24 and 52 or upon treatment discontinuation. Results: We included 80 patients with CD (mean age 55 ± 13y, 35% male) with a median FCP of 268 μg/g (IQR 73–480). After the 12‐month visit, 21 patients (26%) were still on subcutaneous methotrexate monotherapy. Twenty‐one patients stopped because of disease activity, 29 because of toxicity, and four for both reasons. Five patients ended study participation or stopped methotrexate for another reason. A higher MTX‐PG3 concentration was associated with a higher rate of methotrexate drug survival (HR 0.86, 95% CI 0.75–0.99), lower FCP (β −3.7, SE 1.3, p < 0.01) and with biochemical response (FCP ≤250 if baseline >250 μg/g; OR 1.1, 95% CI 1.0–1.3). Higher MTX‐PGs were associated with less gastrointestinal intolerance. There was no robust association between MTX‐PGs and HBI or hepatotoxicity. Conclusions: Higher MTX‐PG3 concentrations are related to better methotrexate drug survival and decreased FCP levels. Therefore, MTX‐PG3 could be used for TDM if a target concentration can be established. [ABSTRACT FROM AUTHOR]

Published
2023
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11. 721: IMMUNOMODULATOR WITHDRAWAL FROM ANTI-TNF THERAPY IS NOT ASSOCIATED WITH LOSS OF RESPONSE IN INFLAMMATORY BOWEL DISEASE

Author

Mahmoud, Remi, primary, Schultheiss, Johannes P., additional, Louwers, Jonas M., additional, Kaaij, Michiel T. van der, additional, Hellemondt, Boris P. van, additional, Mahmmod, Nofel, additional, Boeckel, Petra G. van, additional, Jharap, Bindia, additional, Fidder, Herma H., additional, and Oldenburg, Bas, additional

Published
2022
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12. Tu1498: WITHDRAWAL OF THIOPURINES IN INFLAMMATORY BOWEL DISEASE PATIENTS IN STABLE REMISSION: A PROSPECTIVE, MULTICENTER COHORT STUDY

Author

Savelkoul, Edo, primary, Mahmoud, Remi, additional, Jong, Dirk J. De, additional, Dop, Willemijn A. van, additional, Romkens, Tessa E.H, additional, Nissen, Loes H., additional, Mahmmod, Nofel, additional, Boeckel, Petra G. van, additional, Lutgens, Maurice, additional, Mares, Wout, additional, Epping, Ludger, additional, Minderhoud, Itta M., additional, Jansen, Jeroen M., additional, Gisbertz, Ingrid A., additional, Boekema, Paul, additional, Koning, Daan de, additional, Horje, Carmen S. Horjus Talabur, additional, Jharap, Bindia, additional, Oldenburg, Bas, additional, and Hoentjen, Frank, additional

Published
2022
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13. Mo1539: ANTI-TNF WITHDRAWAL IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE IN ENDOSCOPIC REMISSION: A PROSPECTIVE STUDY

Author

Mahmoud, Remi, primary, Savelkoul, Edo, additional, Mares, Wout, additional, Goetgebuer, Rogier, additional, Witteman, Ben, additional, Koning, Daan de, additional, Minderhoud, Itta M., additional, Tuyl, Sebastiaan van, additional, Boeckel, Petra G. van, additional, Mahmmod, Nofel, additional, Lutgens, Maurice, additional, Horje, Carmen S. Horjus Talabur, additional, Romkens, Tessa E.H, additional, Akol-Simsek, Dilek, additional, Jansen, Jeroen M., additional, Colombel, Jean Frederic, additional, Hoentjen, Frank, additional, Jharap, Bindia, additional, and Oldenburg, Bas, additional

Published
2022
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15. Loss of response to anti-TNF alpha agents depends on treatment duration in patients with inflammatory bowel disease

Author

MS MDL 1, Unit Opleiding MDL, Infection & Immunity, Cancer, Schultheiss, Johannes P D, Mahmoud, Remi, Louwers, Jonas M, van der Kaaij, Michiel T, van Hellemondt, Boris P, van Boeckel, Petra G, Mahmmod, Nofel, Jharap, Bindia, Fidder, Herma H, Oldenburg, Bas, MS MDL 1, Unit Opleiding MDL, Infection & Immunity, Cancer, Schultheiss, Johannes P D, Mahmoud, Remi, Louwers, Jonas M, van der Kaaij, Michiel T, van Hellemondt, Boris P, van Boeckel, Petra G, Mahmmod, Nofel, Jharap, Bindia, Fidder, Herma H, and Oldenburg, Bas

Published
2021

16. Outcome of Reverse Switching From CT-P13 to Originator Infliximab in Patients With Inflammatory Bowel Disease

Author

Arts-assistenten Kinderen, MS MDL 1, Infection & Immunity, Cancer, Mahmmod, Shaden, Schultheiss, Johannes P D, van Bodegraven, Ad A, Dijkstra, Gerard, Gilissen, Lennard P L, Hoentjen, Frank, Lutgens, Maurice W M D, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Smits, Lisa J T, Tan, Adriaan C I T L, Oldenburg, Bas, Fidder, Herma H, Arts-assistenten Kinderen, MS MDL 1, Infection & Immunity, Cancer, Mahmmod, Shaden, Schultheiss, Johannes P D, van Bodegraven, Ad A, Dijkstra, Gerard, Gilissen, Lennard P L, Hoentjen, Frank, Lutgens, Maurice W M D, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Smits, Lisa J T, Tan, Adriaan C I T L, Oldenburg, Bas, and Fidder, Herma H

Published
2021

18. Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients

Author

Brand, Eelco C., primary, Klaassen, Marjolein A.Y., additional, Gacesa, Ranko, additional, Vich Vila, Arnau, additional, Ghosh, Hiren, additional, de Zoete, Marcel R., additional, Boomsma, Dorret I., additional, Hoentjen, Frank, additional, Horjus Talabur Horje, Carmen S., additional, van de Meeberg, Paul C., additional, Willemsen, Gonneke, additional, Fu, Jingyuan, additional, Wijmenga, Cisca, additional, van Wijk, Femke, additional, Zhernakova, Alexandra, additional, Oldenburg, Bas, additional, Weersma, Rinse K., additional, Brand, Eelco C., additional, Honkoop, Pieter, additional, Jacobs, Rutger J., additional, Ponsioen, Cyriel Y., additional, de Boer, Nanne K.H., additional, Alderlieste, Yasser A., additional, van Herwaarden, Margot A., additional, van Tuyl, Sebastiaan A.C., additional, Lutgens, Maurice W., additional, Janneke van der Woude, C., additional, Mares, Wout G.M., additional, de Koning, Daan B., additional, Bosman, Joukje H., additional, Vecht, Juda, additional, de Schryver, Anneke M.P., additional, van der Meulen-de Jong, Andrea E., additional, Pierik, Marieke J., additional, Boekema, Paul J., additional, Verburg, Robert J., additional, Jharap, Bindia, additional, Jansen, Jeroen M., additional, Stokkers, Pieter C.F., additional, Quispel, Rutger, additional, Mahmmod, Nofel, additional, West, Rachel L., additional, Willems, Marleen, additional, Minderhoud, Itta M., additional, Fidder, Herma H., additional, van Schaik, Fiona D.M., additional, Hirdes, Meike M.C., additional, Boontje, Nynke A., additional, Müskens, Bart L.M., additional, and Romberg-Camps, Marielle J.L., additional

Published
2021
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19. Anti-tumor necrosis factor therapy in patients with inflammatory bowel disease; comorbidity, not patient age, is a predictor of severe adverse events

Author

Zorgeenheid Traumatologie, MS MDL 1, Infection & Immunity, Cancer, Asscher, Vera E R, van der Vliet, Quirine, van der Aalst, Karen, van der Aalst, Anniek, Brand, Eelco C, van der Meulen-de Jong, Andrea E, Oldenburg, Bas, Pierik, Marieke J, van Tuyl, Bas, Mahmmod, Nofel, Maljaars, P W Jeroen, Fidder, Herma H, Dutch ICC, Zorgeenheid Traumatologie, MS MDL 1, Infection & Immunity, Cancer, Asscher, Vera E R, van der Vliet, Quirine, van der Aalst, Karen, van der Aalst, Anniek, Brand, Eelco C, van der Meulen-de Jong, Andrea E, Oldenburg, Bas, Pierik, Marieke J, van Tuyl, Bas, Mahmmod, Nofel, Maljaars, P W Jeroen, Fidder, Herma H, and Dutch ICC

Published
2020

20. Consecutive negative findings on colonoscopy during surveillance predict a low risk of advanced neoplasia in patients with inflammatory bowel disease with long-standing colitis : results of a 15-year multicentre, multinational cohort study

Author

Ten Hove, Joren R, Shah, Shailja C, Shaffer, Seth R, Bernstein, Charles N, Castaneda, Daniel, Palmela, Carolina, Mooiweer, Erik, Elman, Jordan, Kumar, Akash, Glass, Jason, Axelrad, Jordan, Ullman, Thomas A, Colombel, Jean-Frederic, Torres, Joana, van Bodegraven, Adriaan A, Hoentjen, Frank, Jansen, Jeroen M, de Jong, Michiel E, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Ponsioen, Cyriel Y, van der Woude, Christine J, Itzkowitz, Steven H, Oldenburg, Bas, Ten Hove, Joren R, Shah, Shailja C, Shaffer, Seth R, Bernstein, Charles N, Castaneda, Daniel, Palmela, Carolina, Mooiweer, Erik, Elman, Jordan, Kumar, Akash, Glass, Jason, Axelrad, Jordan, Ullman, Thomas A, Colombel, Jean-Frederic, Torres, Joana, van Bodegraven, Adriaan A, Hoentjen, Frank, Jansen, Jeroen M, de Jong, Michiel E, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Ponsioen, Cyriel Y, van der Woude, Christine J, Itzkowitz, Steven H, and Oldenburg, Bas

Published
2019

21. Malignant and Nonmalignant Complications of the Rectal Stump in Patients with Inflammatory Bowel Disease

Author

Ten Hove, Joren R, Bogaerts, Jonathan M K, Bak, Michiel T J, Laclé, Miangela M, Meij, Vincent, Derikx, Lauranne A A P, Hoentjen, Frank, Mahmmod, Nofel, van Tuyl, Sebastiaan A, Oldenburg, Bas, Ten Hove, Joren R, Bogaerts, Jonathan M K, Bak, Michiel T J, Laclé, Miangela M, Meij, Vincent, Derikx, Lauranne A A P, Hoentjen, Frank, Mahmmod, Nofel, van Tuyl, Sebastiaan A, and Oldenburg, Bas

Published
2019

22. Malignant and Nonmalignant Complications of the Rectal Stump in Patients with Inflammatory Bowel Disease

Author

MS MDL 1, Pathologie Pathologen staf, MS CGO, Infection & Immunity, Ten Hove, Joren R, Bogaerts, Jonathan M K, Bak, Michiel T J, Laclé, Miangela M, Meij, Vincent, Derikx, Lauranne A A P, Hoentjen, Frank, Mahmmod, Nofel, van Tuyl, Sebastiaan A, Oldenburg, Bas, MS MDL 1, Pathologie Pathologen staf, MS CGO, Infection & Immunity, Ten Hove, Joren R, Bogaerts, Jonathan M K, Bak, Michiel T J, Laclé, Miangela M, Meij, Vincent, Derikx, Lauranne A A P, Hoentjen, Frank, Mahmmod, Nofel, van Tuyl, Sebastiaan A, and Oldenburg, Bas

Published
2019

23. Consecutive negative findings on colonoscopy during surveillance predict a low risk of advanced neoplasia in patients with inflammatory bowel disease with long-standing colitis: results of a 15-year multicentre, multinational cohort study

Author

MS MDL 1, Cancer, Infection & Immunity, Ten Hove, Joren R, Shah, Shailja C, Shaffer, Seth R, Bernstein, Charles N, Castaneda, Daniel, Palmela, Carolina, Mooiweer, Erik, Elman, Jordan, Kumar, Akash, Glass, Jason, Axelrad, Jordan, Ullman, Thomas A, Colombel, Jean-Frederic, Torres, Joana, van Bodegraven, Adriaan A, Hoentjen, Frank, Jansen, Jeroen M, de Jong, Michiel E, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Ponsioen, Cyriel Y, van der Woude, Christine J, Itzkowitz, Steven H, Oldenburg, Bas, MS MDL 1, Cancer, Infection & Immunity, Ten Hove, Joren R, Shah, Shailja C, Shaffer, Seth R, Bernstein, Charles N, Castaneda, Daniel, Palmela, Carolina, Mooiweer, Erik, Elman, Jordan, Kumar, Akash, Glass, Jason, Axelrad, Jordan, Ullman, Thomas A, Colombel, Jean-Frederic, Torres, Joana, van Bodegraven, Adriaan A, Hoentjen, Frank, Jansen, Jeroen M, de Jong, Michiel E, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Ponsioen, Cyriel Y, van der Woude, Christine J, Itzkowitz, Steven H, and Oldenburg, Bas

Published
2019

24. Anti-tumor necrosis factor therapy in patients with inflammatory bowel disease; comorbidity, not patient age, is a predictor of severe adverse events.

Author

Asscher, Vera E. R., van der Vliet, Quirine, van der Aalst, Karen, van der Aalst, Anniek, Brand, Eelco C., van der Meulen-de Jong, Andrea E., Oldenburg, Bas, Pierik, Marieke J., van Tuyl, Bas, Mahmmod, Nofel, Maljaars, P. W. Jeroen, and Fidder, Herma H.

Subjects
INFLAMMATORY bowel diseases, OLDER patients, CROHN'S disease, NECROSIS, COMORBIDITY
Abstract

Purpose: To assess safety and effectiveness of anti-tumor necrosis factor (anti-TNF) therapy in IBD patients ≥ 60 years. Methods: Ninety IBD patients ≥ 60 years at initiation of anti-TNF therapy, 145 IBD patients ≥ 60 years without anti-TNF therapy and 257 IBD patients < 60 years at initiation of anti-TNF therapy were retrospectively included in this multicentre study. Primary outcome was the occurrence of severe adverse events (SAEs), serious infections and malignancies. Secondary outcome was effectiveness of therapy. Cox regression analyses were used to assess differences in safety and effectiveness. In safety analyses, first older patients with and without anti-TNF therapy and then older and younger patients with anti-TNF therapy were assessed. Results: In older IBD patients, the use of anti-TNF therapy was associated with serious infections (aHR 3.920, 95% CI 1.185–12.973, p =.025). In anti-TNF-exposed patients, cardiovascular disease associated with serious infections (aHR 3.279, 95% CI 1.098–9.790, p =.033) and the presence of multiple comorbidities (aHR 9.138 (1.248–66.935), p =.029) with malignancies, while patient age did not associate with safety outcomes. Effectiveness of therapy was not affected by age or comorbidity. Conclusion: Older patients receiving anti-TNF therapy have a higher risk of serious infections compared with older IBD patients without anti-TNF therapy, but not compared with younger patients receiving anti-TNF therapy. However, in anti-TNF-exposed patients, comorbidity was found to be an indicator with regards to SAEs. Effectiveness was comparable between older and younger patients. [ABSTRACT FROM AUTHOR]

Published
2020
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25. 604 - Consecutive Negative Findings on Colonoscopy During Surveillance Predict a Low Risk of Advanced Neoplasia in Patients with Longstanding Colitis: Results of a 15-Year Multicenter, Multinational Cohort Study

Author

Shah, Shailja, primary, Ten Hove, Joren, additional, Shaffer, Seth, additional, Bernstein, Charles N., additional, Castaneda, Daniel, additional, Palmela, Carolina, additional, Mooiweer, Erik, additional, Elman, Jordan, additional, Kumar, Akash, additional, Axelrad, Jordan, additional, Glass, Jason, additional, Ullman, Thomas A., additional, Colombel, Jean Frederic, additional, Torres, Joana, additional, van Bodegraven, Adriaan A., additional, Hoentjen, Frank, additional, Jansen, Jeroen, additional, de Jong, Michiel E., additional, Mahmmod, Nofel, additional, Van Der Meulen, Andrea, additional, Ponsioen, Cyriel, additional, Van Der Woude, Christien Janneke, additional, Itzkowitz, Steven, additional, and Oldenburg, Bas, additional

Published
2018
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26. Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNF alpha therapy

Author

Van Der Valk, Mirthe Emilie, Mangen, Marie Josée J, Leenders, Max, Dijkstra, Gerard, Van Bodegraven, Ad A., Fidder, Herma H., De Jong, Dirk J., Pierik, Marieke, Van Der Woude, C. Janneke, Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, J.M., Mahmmod, Nofel, Van De Meeberg, Paul C., Van Der Meulen-De Jong, Andrea E., Ponsioen, Cyriel Y., Bolwerk, Clemens J M, Vermeijden, J. Reinoud, Siersema, Peter D., Van Oijen, Martijn G H, Oldenburg, Bas, LS IRAS EEPI GRA (Gezh.risico-analyse), IRAS RATIA-SIB, Risk Assessment of Toxic and Immunomodulatory Agents, LS IRAS EEPI GRA (Gezh.risico-analyse), IRAS RATIA-SIB, Risk Assessment of Toxic and Immunomodulatory Agents, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Groningen Institute for Organ Transplantation (GIOT), Interne Geneeskunde, Health promotion, RS: NUTRIM - R2 - Gut-liver homeostasis, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology, Oncology, Gastroenterology and hepatology, CCA - Quality of life, and Gastroenterology & Hepatology

Subjects
Male, Total cost, Anti-Inflammatory Agents, Crohn's Disease, Inflammatory bowel disease, Quality of life, Cost of Illness, Crohn Disease, QUALITY-OF-LIFE, Surveys and Questionnaires, Epidemiology, Absenteeism, Outpatient clinic, EPIDEMIOLOGY, health care economics and organizations, Netherlands, Aged, 80 and over, Crohn's disease, Gastroenterology, Antibodies, Monoclonal, Health Care Costs, Middle Aged, Ulcerative colitis, WORK PRODUCTIVITY, CROHNS-DISEASE, Hospitalization, ULCERATIVE-COLITIS, Sick leave, Female, Sick Leave, BURDEN, Adult, medicine.medical_specialty, Adolescent, ORTHOPEDIC-SURGERY, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], ILLNESS, Antibodies, Monoclonal, Humanized, Young Adult, medicine, Humans, Ulcerative Colitis, Aged, business.industry, Inflammatory Bowel Disease, Adalimumab, medicine.disease, Infliximab, EVOLUTION, Surgery, RHEUMATOID-ARTHRITIS, Logistic Models, Multivariate Analysis, Colitis, Ulcerative, Health Expenditures, business, Economic Evaluation, Follow-Up Studies
Abstract

Item does not contain fulltext OBJECTIVE: The introduction of anti tumour necrosis factor-alpha (anti-TNFalpha) therapy might impact healthcare expenditures, but there are limited data regarding the costs of inflammatory bowel diseases (IBD) following the introduction of these drugs. We aimed to assess the healthcare costs and productivity losses in a large cohort of IBD patients. DESIGN: Crohn's disease (CD) and ulcerative colitis (UC) patients from seven university hospitals and seven general hospitals were invited to fill-out a web-based questionnaire. Cost items were derived from a 3 month follow-up questionnaire and categorised in outpatient clinic, diagnostics, medication, surgery and hospitalisation. Productivity losses included sick leave of paid and unpaid work. Costs were expressed as mean 3-month costs per patients with a 95% CI obtained using non-parametric bootstrapping. RESULTS: A total of 1315 CD patients and 937 UC patients were included. Healthcare costs were almost three times higher in CD as compared with UC, euro1625 (95% CI euro1476 to euro1775) versus euro595 (95% CI euro505 to euro685), respectively (p

Published
2014
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27. Telemedicine Enables a Safe Shift from Examination Room Based Care to Personalized Care for Inflammatory Bowel Disease: A Pragmatic Randomized Multicenter Trial With Myibdcoach

Author

de Jong, Marin, primary, Van Der Meulen, Andrea, additional, Romberg-Camps, Marielle, additional, Becx, Marco, additional, Cilissen, Mia, additional, Maljaars, Jeroen, additional, van Bodegraven, Ad, additional, Mahmmod, Nofel, additional, Markus-de Kwaadsteniet, M.L., additional, Hameeteman, Wim, additional, Dijkstra, Gerard, additional, Masclee, Ad, additional, Boonen, Annelies, additional, Jonkers, Daisy, additional, van Tubergen, Astrid, additional, and Pierik, Marie, additional

Published
2017
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28. Clinical Predictors of Future Nonadherence in Inflammatory Bowel Disease

Author

Severs, Mirjam, Mangen, Marie Josée J., Fidder, Herma H., Van Der Valk, Mirthe E., Van Der Have, Mike, Van Bodegraven, Ad A., Clemens, Cees H M, Dijkstra, Gerard, Jansen, Jeroen M., de Jong, Dirk J, Mahmmod, Nofel, van de Meeberg, Paul C, Van der Meulen-de Jong, Andrea E, Pierik, Marieke, Ponsioen, Cyriel Y, Romberg-Camps, Marielle J.L., Siersema, Peter D., Jharap, Bindia, van der Woude, C Janneke, Zuithoff, Nicolaas P.A., Oldenburg, Bas, Severs, Mirjam, Mangen, Marie Josée J., Fidder, Herma H., Van Der Valk, Mirthe E., Van Der Have, Mike, Van Bodegraven, Ad A., Clemens, Cees H M, Dijkstra, Gerard, Jansen, Jeroen M., de Jong, Dirk J, Mahmmod, Nofel, van de Meeberg, Paul C, Van der Meulen-de Jong, Andrea E, Pierik, Marieke, Ponsioen, Cyriel Y, Romberg-Camps, Marielle J.L., Siersema, Peter D., Jharap, Bindia, van der Woude, C Janneke, Zuithoff, Nicolaas P.A., and Oldenburg, Bas

Published
2017

29. Clinical Predictors of Future Nonadherence in Inflammatory Bowel Disease

Author

UMC Utrecht, Unit Opleiding Aios, Cancer, HEE, MS MDL 1, Infection & Immunity, Arts Assistenten Longziekten, Biostatistiek Onderzoek, Other research (not in main researchprogram), Severs, Mirjam, Mangen, Marie Josée J., Fidder, Herma H., Van Der Valk, Mirthe E., Van Der Have, Mike, Van Bodegraven, Ad A., Clemens, Cees H M, Dijkstra, Gerard, Jansen, Jeroen M., de Jong, Dirk J, Mahmmod, Nofel, van de Meeberg, Paul C, Van der Meulen-de Jong, Andrea E, Pierik, Marieke, Ponsioen, Cyriel Y, Romberg-Camps, Marielle J.L., Siersema, Peter D., Jharap, Bindia, van der Woude, C Janneke, Zuithoff, Nicolaas P.A., Oldenburg, Bas, UMC Utrecht, Unit Opleiding Aios, Cancer, HEE, MS MDL 1, Infection & Immunity, Arts Assistenten Longziekten, Biostatistiek Onderzoek, Other research (not in main researchprogram), Severs, Mirjam, Mangen, Marie Josée J., Fidder, Herma H., Van Der Valk, Mirthe E., Van Der Have, Mike, Van Bodegraven, Ad A., Clemens, Cees H M, Dijkstra, Gerard, Jansen, Jeroen M., de Jong, Dirk J, Mahmmod, Nofel, van de Meeberg, Paul C, Van der Meulen-de Jong, Andrea E, Pierik, Marieke, Ponsioen, Cyriel Y, Romberg-Camps, Marielle J.L., Siersema, Peter D., Jharap, Bindia, van der Woude, C Janneke, Zuithoff, Nicolaas P.A., and Oldenburg, Bas

Published
2017

30. Evolution of Costs of Inflammatory Bowel Disease over Two Years of Follow-Up

Author

van der Valk, Mirthe E, Mangen, Marie-Josée J, Severs, Mirjam, van der Have, Mike, Dijkstra, Gerard, van Bodegraven, Ad A, Fidder, Herma H, de Jong, Dirk J, van der Woude, C Janneke, Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, Jeroen M, van de Meeberg, Paul C, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Ponsioen, Cyriel Y, Bolwerk, Clemens, Vermeijden, J Reinoud, Siersema, Peter D, Leenders, Max, Oldenburg, Bas, COIN study group and the Dutch Initiative on Crohn and Colitis, van der Valk, Mirthe E, Mangen, Marie-Josée J, Severs, Mirjam, van der Have, Mike, Dijkstra, Gerard, van Bodegraven, Ad A, Fidder, Herma H, de Jong, Dirk J, van der Woude, C Janneke, Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, Jeroen M, van de Meeberg, Paul C, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Ponsioen, Cyriel Y, Bolwerk, Clemens, Vermeijden, J Reinoud, Siersema, Peter D, Leenders, Max, Oldenburg, Bas, and COIN study group and the Dutch Initiative on Crohn and Colitis

Published
2016

31. Evolution of Costs of Inflammatory Bowel Disease over Two Years of Follow-Up

Author

HTA Onderzoek Team 1, JC onderzoeksprogramma Infectious Diseases, Circulatory Health, JC onderzoeksprogramma Methodology, MS MDL 1, Cancer, Unit Opleiding Aios, Infection & Immunity, van der Valk, Mirthe E, Mangen, Marie-Josée J, Severs, Mirjam, van der Have, Mike, Dijkstra, Gerard, van Bodegraven, Ad A, Fidder, Herma H, de Jong, Dirk J, van der Woude, C Janneke, Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, Jeroen M, van de Meeberg, Paul C, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Ponsioen, Cyriel Y, Bolwerk, Clemens, Vermeijden, J Reinoud, Siersema, Peter D, Leenders, Max, Oldenburg, Bas, COIN study group and the Dutch Initiative on Crohn and Colitis, HTA Onderzoek Team 1, JC onderzoeksprogramma Infectious Diseases, Circulatory Health, JC onderzoeksprogramma Methodology, MS MDL 1, Cancer, Unit Opleiding Aios, Infection & Immunity, van der Valk, Mirthe E, Mangen, Marie-Josée J, Severs, Mirjam, van der Have, Mike, Dijkstra, Gerard, van Bodegraven, Ad A, Fidder, Herma H, de Jong, Dirk J, van der Woude, C Janneke, Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, Jeroen M, van de Meeberg, Paul C, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Ponsioen, Cyriel Y, Bolwerk, Clemens, Vermeijden, J Reinoud, Siersema, Peter D, Leenders, Max, Oldenburg, Bas, and COIN study group and the Dutch Initiative on Crohn and Colitis

Published
2016

32. Su1801 One Simple Question Is Sufficient for Measuring Medication Adherence in Inflammatory Bowel Disease Patients Using Self-Report

Author

Severs, Mirjam, primary, Mangen, Marie-Josée J., additional, Fidder, Herma H., additional, Van Der Valk, Mirthe E., additional, Van Der Have, Mike, additional, Van Bodegraven, Adriaan A., additional, Clemens, Cees H., additional, Dijkstra, Gerard, additional, Jeroen, M, additional, De Jong, Dirk J., additional, Mahmmod, Nofel, additional, van de Meeberg, Paul C., additional, Van Der Meulen, Andrea, additional, Pierik, Marie, additional, Ponsioen, Cyriel, additional, Romberg-Camps, Marielle, additional, Siersema, Peter D., additional, Vermeijden, Reinoud J., additional, Van Der Woude, Christien Janneke, additional, Zuithoff, Peter N., additional, and Oldenburg, Bas, additional

Published
2016
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33. Sa1944 Non-Adherence to Medical Therapy Is Associated With Hospitalizations and the Development of Active Disease in Inflammatory Bowel Disease

Author

Severs, Mirjam, primary, Fidder, Herma H., additional, Mangen, Marie-Josée J., additional, van der Valk, Mirthe E., additional, van der Have, Mike, additional, van Bodegraven, Adriaan A., additional, Clemens, Cees H., additional, Dijkstra, Gerard, additional, Jeroen, M, additional, De Jong, Dirk J., additional, Mahmmod, Nofel, additional, van de Meeberg, Paul C., additional, van der Meulen, Andrea, additional, Pierik, Marie, additional, Ponsioen, Cyriel, additional, Romberg-Camps, Marielle, additional, Siersema, Peter D., additional, Vermeijden, Reinoud J., additional, van der Woude, Christien Janneke, additional, Zuithoff, Peter N., additional, and Oldenburg, Bas, additional

Published
2016
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34. Sa1945 Lower Quality of Life, More Active Disease and Increased Healthcare Costs Due to Non-Adherence in Inflammatory Bowel Disease

Author

Severs, Mirjam, primary, Mangen, Marie-Josée J., additional, Fidder, Herma H., additional, van der Valk, Mirthe E., additional, van der Have, Mike, additional, van Bodegraven, Adriaan A., additional, Clemens, Cees H., additional, Dijkstra, Gerard, additional, Jeroen, M, additional, De Jong, Dirk J., additional, Mahmmod, Nofel, additional, van de Meeberg, Paul C., additional, van der Meulen, Andrea, additional, Pierik, Marie, additional, Ponsioen, Cyriel, additional, Romberg-Camps, Marielle, additional, Siersema, Peter D., additional, Vermeijden, Reinoud J., additional, van der Woude, Christien Janneke, additional, Zuithoff, Peter N., additional, and Oldenburg, Bas, additional

Published
2016
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35. Effect of Aging on Healthcare Costs of Inflammatory Bowel Disease: A Glimpse into the Future

Author

Van Der Have, Mike, Mangen, Marie Josée J, Van Der Valk, Mirthe E., Smeets, Hugo M., Van Bodegraven, Ad, Dijkstra, Gerard, Fidder, Herma H., De Jong, Dirk J., Pierik, Marieke, Ponsioen, Cyriel Y., Van Der Meulen-De Jong, Andrea E., Van Der Woude, Ca Janneke, Van De Meeberg, Paul C., Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, J.M., Mahmmod, Nofel, Bolwerk, Clemens J M, Vermeijden, J. Reinoud, Siersema, Peter D., Leenders, Max, Oldenburg, Bas, LS IRAS EEPI GRA (Gezh.risico-analyse), IRAS RATIA-SIB, Risk Assessment of Toxic and Immunomodulatory Agents, Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology, Public Health, Gastroenterology & Hepatology, Gastroenterology and hepatology, CCA - Innovative therapy, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Groningen Institute for Organ Transplantation (GIOT), Interne Geneeskunde, Health promotion, RS: NUTRIM - R2 - Gut-liver homeostasis, LS IRAS EEPI GRA (Gezh.risico-analyse), IRAS RATIA-SIB, and Risk Assessment of Toxic and Immunomodulatory Agents

Subjects
Male, Aging, MEDICAL COST, Prevalence, Efficiency, DUTCH, Inflammatory bowel disease, Cost of Illness, Health Transition, Surveys and Questionnaires, Health care, Immunology and Allergy, Young adult, ELDERLY-PATIENTS, POPULATION, Netherlands, RISK, education.field_of_study, Elderly persons, Age Factors, Gastroenterology, Health Care Costs, Health Services, Middle Aged, Ulcerative colitis, CROHNS-DISEASE, ULCERATIVE-COLITIS, elderly persons, Cohort, Female, Adult, Population ageing, medicine.medical_specialty, endocrine system, Adolescent, Population, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], VALIDATION, healthcare costs, Young Adult, inflammatory bowel disease, medicine, Humans, education, business.industry, aging, Healthcare costs, medicine.disease, Inflammatory Bowel Diseases, digestive system diseases, Surgery, RHEUMATOID-ARTHRITIS, business, Demography, Forecasting
Abstract

BACKGROUND:: Population aging is expected to result in a substantial additional burden on healthcare resources in the near future. We aimed to assess the current and future impact of aging on direct healthcare costs (DHC) attributed to inflammatory bowel disease (IBD). METHODS:: Patients with IBD from a Dutch multicenter cohort filled out 3-monthly questionnaires for 2 years. Elderly (>/=60 yr) and younger patients (18-60 yr) IBD were analyzed for differences in 3-monthly DHC, productivity losses, and out-of-pocket costs. Prevalence rates were obtained from a health insurance database. Estimates of annual DHC and prevalence rates were applied to the total Dutch adult population in 2011 and then projected to 2040, using predicted changes in population demography, prices, and volume. RESULTS:: IBD-attributable DHC were lower in elderly than in younger patients with IBD with respect to 3-monthly DHC (&OV0556;359 versus &OV0556;978, P < 0.01), productivity losses (&OV0556;108 versus &OV0556;456, P < 0.01), and out-of-pocket costs (&OV0556;40 versus &OV0556;57, P < 0.01). Between 2011 and 2040, the percentage of elderly IBD patients in the Netherlands has been projected to rise from 24% to 35%. Between 2011 and 2040, DHC of the total IBD population in the Netherlands are projected to increase from &OV0556;161 to &OV0556;661 million. Population aging accounted for 1% of this increase, next to rising prices (29%), and volume growth (70%). CONCLUSIONS:: Population aging has a negligible effect on IBD-attributable DHC of the IBD population in the near future, because the average costs incurred by elderly patients with IBD are considerably lower than those incurred by younger patients with IBD.

Published
2014
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36. Self-reported disability in patients with inflammatory bowel disease largely determined by disease activity and illness perceptions

Author

van der Have, Mike, Fidder, Herma H, Leenders, Max, Kaptein, Ad A, van der Valk, Mirthe E, van Bodegraven, Ad A, Dijkstra, Gerard, de Jong, Dirk J, Pierik, Marieke, Ponsioen, Cyriel Y, van der Meulen-de Jong, Andrea E, van der Woude, C Janneke, van de Meeberg, Paul C, Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, Jeroen M, Mahmmod, Nofel, Bolwerk, Clemens J M, Vermeijden, J Reinoud, Siersema, Peter D, Oldenburg, Bas, COIN study group, van der Have, Mike, Fidder, Herma H, Leenders, Max, Kaptein, Ad A, van der Valk, Mirthe E, van Bodegraven, Ad A, Dijkstra, Gerard, de Jong, Dirk J, Pierik, Marieke, Ponsioen, Cyriel Y, van der Meulen-de Jong, Andrea E, van der Woude, C Janneke, van de Meeberg, Paul C, Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, Jeroen M, Mahmmod, Nofel, Bolwerk, Clemens J M, Vermeijden, J Reinoud, Siersema, Peter D, Oldenburg, Bas, and COIN study group

Published
2015

37. Incidence of Interval Colorectal Cancer Among Inflammatory Bowel Disease Patients Undergoing Regular Colonoscopic Surveillance

Author

UMC Utrecht, Cancer, MS MDL 1, MS MDL Oncologie, Infection & Immunity, Mooiweer, Erik, van der Meulen-de Jong, Andrea E., Ponsioen, Cyriel Y., van der Woude, C. Janneke, van Bodegraven, Ad A., Jansen, Jeroen M., Mahmmod, Nofel, Kremer, Willemijn, Siersema, Peter D., Oldenburg, Bas, UMC Utrecht, Cancer, MS MDL 1, MS MDL Oncologie, Infection & Immunity, Mooiweer, Erik, van der Meulen-de Jong, Andrea E., Ponsioen, Cyriel Y., van der Woude, C. Janneke, van Bodegraven, Ad A., Jansen, Jeroen M., Mahmmod, Nofel, Kremer, Willemijn, Siersema, Peter D., and Oldenburg, Bas

Published
2015

38. Self-reported disability in patients with inflammatory bowel disease largely determined by disease activity and illness perceptions

Author

Unit Opleiding Aios, Infection & Immunity, MS MDL 1, Cancer, MS MDL Oncologie, van der Have, Mike, Fidder, Herma H, Leenders, Max, Kaptein, Ad A, van der Valk, Mirthe E, van Bodegraven, Ad A, Dijkstra, Gerard, de Jong, Dirk J, Pierik, Marieke, Ponsioen, Cyriel Y, van der Meulen-de Jong, Andrea E, van der Woude, C Janneke, van de Meeberg, Paul C, Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, Jeroen M, Mahmmod, Nofel, Bolwerk, Clemens J M, Vermeijden, J Reinoud, Siersema, Peter D, Oldenburg, Bas, COIN Study Group, Unit Opleiding Aios, Infection & Immunity, MS MDL 1, Cancer, MS MDL Oncologie, van der Have, Mike, Fidder, Herma H, Leenders, Max, Kaptein, Ad A, van der Valk, Mirthe E, van Bodegraven, Ad A, Dijkstra, Gerard, de Jong, Dirk J, Pierik, Marieke, Ponsioen, Cyriel Y, van der Meulen-de Jong, Andrea E, van der Woude, C Janneke, van de Meeberg, Paul C, Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, Jeroen M, Mahmmod, Nofel, Bolwerk, Clemens J M, Vermeijden, J Reinoud, Siersema, Peter D, Oldenburg, Bas, and COIN Study Group

Published
2015

39. Su1300 Healthcare Expenditures for Inflammatory Bowel Disease Peak in Patients With a Short Disease Duration

Author

Severs, Mirjam, primary, van der Valk, Mirthe E., additional, Mangen, Marie-Josée Justine, additional, Have, Mike V., additional, Dijkstra, Gerard, additional, van Bodegraven, Adriaan A., additional, Fidder, Herma, additional, De Jong, Dirk J., additional, Pierik, Marie J., additional, van der Woude, Christien J., additional, Romberg-Camps, Mariëlle, additional, Clemens, Cees H., additional, Jansen, Jeroen M., additional, van de Meeberg, Paul C., additional, Mahmmod, Nofel, additional, van der Meulen - de Jong, Andrea E., additional, Ponsioen, Cyriel, additional, Bolwerk, Clemens, additional, Vermeijden, J.R., additional, Siersema, Peter D., additional, Leenders, Max, additional, and Oldenburg, Bas, additional

Published
2015
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40. Tu1243 Evolution of IBD-Related Costs Over Two Years of Follow up: Increase of Anti-TNF α Therapy Related Costs With a Decline of Hospitalization Costs

Author

van der Valk, Mirthe E., primary, Mangen, Marie-Josée Justine, additional, Have, Mike V., additional, Severs, Mirjam, additional, Dijkstra, Gerard, additional, van Bodegraven, Adriaan A., additional, Fidder, Herma, additional, De Jong, Dirk J., additional, Pierik, Marie J., additional, van der Woude, Christien J., additional, Romberg-Camps, Mariëlle, additional, Clemens, Cees H., additional, Jansen, Jeroen M., additional, van de Meeberg, Paul C., additional, Mahmmod, Nofel, additional, van der Meulen - de Jong, Andrea E., additional, Ponsioen, Cyriel, additional, Bolwerk, Clemens, additional, Vermeijden, J.R., additional, Siersema, Peter D., additional, Leenders, Max, additional, and Oldenburg, Bas, additional

Published
2015
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41. Su1299 Smoking Is Associated With Extra-Intestinal Manifestations in Inflammatory Bowel Disease

Author

Severs, Mirjam, primary, van Erp, Sanne JH, additional, Dijkstra, Gerard, additional, van der Valk, Mirthe E., additional, Mangen, Marie-Josée Justine, additional, Have, Mike V., additional, van Bodegraven, Adriaan A., additional, Fidder, Herma, additional, De Jong, Dirk J., additional, Pierik, Marie J., additional, van der Woude, Christien J., additional, Romberg-Camps, Mariëlle, additional, Clemens, Cees H., additional, Jansen, Jeroen M., additional, van de Meeberg, Paul C., additional, Mahmmod, Nofel, additional, Ponsioen, Cyriel, additional, Bolwerk, Clemens, additional, Vermeijden, J.R., additional, Siersema, Peter D., additional, Leenders, Max, additional, van der Meulen - de Jong, Andrea E., additional, and Oldenburg, Bas, additional

Published
2015
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42. Sa1155 Smoking Is Associated With Higher Healthcare Costs in IBD Patients, Primarily Due to More Frequent Anti-TNFα Use

Author

Severs, Mirjam, primary, van der Valk, Mirthe E., additional, Mangen, Marie-Josée Justine, additional, Have, Mike V., additional, Dijkstra, Gerard, additional, van Bodegraven, Adriaan A., additional, Fidder, Herma, additional, De Jong, Dirk J., additional, Pierik, Marie J., additional, van der Woude, Christien J., additional, Romberg-Camps, Mariëlle, additional, Clemens, Cees H., additional, Jansen, Jeroen M., additional, van de Meeberg, Paul C., additional, Mahmmod, Nofel, additional, van der Meulen - de Jong, Andrea E., additional, Ponsioen, Cyriel, additional, Bolwerk, Clemens, additional, Vermeijden, J.R., additional, Siersema, Peter D., additional, Leenders, Max, additional, and Oldenburg, Bas, additional

Published
2015
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43. 982 - Telemedicine Enables a Safe Shift from Examination Room Based Care to Personalized Care for Inflammatory Bowel Disease: A Pragmatic Randomized Multicenter Trial With Myibdcoach

Author

de Jong, Marin, Van Der Meulen, Andrea, Romberg-Camps, Marielle, Becx, Marco, Cilissen, Mia, Maljaars, Jeroen, van Bodegraven, Ad, Mahmmod, Nofel, Markus-de Kwaadsteniet, M.L., Hameeteman, Wim, Dijkstra, Gerard, Masclee, Ad, Boonen, Annelies, Jonkers, Daisy, van Tubergen, Astrid, and Pierik, Marie

Published
2017
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44. Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFα therapy : Results from the COIN study

Author

Van Der Valk, Mirthe Emilie, Mangen, Marie Josée J, Leenders, Max, Dijkstra, Gerard, Van Bodegraven, Ad A., Fidder, Herma H., De Jong, Dirk J., Pierik, Marieke, Van Der Woude, C. Janneke, Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, J.M., Mahmmod, Nofel, Van De Meeberg, Paul C., Van Der Meulen-De Jong, Andrea E., Ponsioen, Cyriel Y., Bolwerk, Clemens J M, Vermeijden, J. Reinoud, Siersema, Peter D., Van Oijen, Martijn G H, Oldenburg, Bas, Van Der Valk, Mirthe Emilie, Mangen, Marie Josée J, Leenders, Max, Dijkstra, Gerard, Van Bodegraven, Ad A., Fidder, Herma H., De Jong, Dirk J., Pierik, Marieke, Van Der Woude, C. Janneke, Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, J.M., Mahmmod, Nofel, Van De Meeberg, Paul C., Van Der Meulen-De Jong, Andrea E., Ponsioen, Cyriel Y., Bolwerk, Clemens J M, Vermeijden, J. Reinoud, Siersema, Peter D., Van Oijen, Martijn G H, and Oldenburg, Bas

Published
2014

45. Effect of aging on healthcare costs of inflammatory bowel disease: A glimpse into the future

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), IRAS RATIA-SIB, Risk Assessment of Toxic and Immunomodulatory Agents, Van Der Have, Mike, Mangen, Marie Josée J, Van Der Valk, Mirthe E., Smeets, Hugo M., Van Bodegraven, Ad, Dijkstra, Gerard, Fidder, Herma H., De Jong, Dirk J., Pierik, Marieke, Ponsioen, Cyriel Y., Van Der Meulen-De Jong, Andrea E., Van Der Woude, Ca Janneke, Van De Meeberg, Paul C., Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, J.M., Mahmmod, Nofel, Bolwerk, Clemens J M, Vermeijden, J. Reinoud, Siersema, Peter D., Leenders, Max, Oldenburg, Bas, LS IRAS EEPI GRA (Gezh.risico-analyse), IRAS RATIA-SIB, Risk Assessment of Toxic and Immunomodulatory Agents, Van Der Have, Mike, Mangen, Marie Josée J, Van Der Valk, Mirthe E., Smeets, Hugo M., Van Bodegraven, Ad, Dijkstra, Gerard, Fidder, Herma H., De Jong, Dirk J., Pierik, Marieke, Ponsioen, Cyriel Y., Van Der Meulen-De Jong, Andrea E., Van Der Woude, Ca Janneke, Van De Meeberg, Paul C., Romberg-Camps, Mariëlle J L, Clemens, Cees H M, Jansen, J.M., Mahmmod, Nofel, Bolwerk, Clemens J M, Vermeijden, J. Reinoud, Siersema, Peter D., Leenders, Max, and Oldenburg, Bas

Published
2014

46. Su1326 Self-Reported Disability Index in Inflammatory Bowel Disease: Results From a Large Dutch Prospective Cohort

Author

Have, Mike V., primary, Fidder, Herma, additional, Leenders, Max, additional, Kaptein, Adrian A., additional, van der Valk, Mirthe E., additional, van Bodegraven, Adriaan A., additional, Dijkstra, Gerard, additional, De Jong, Dirk J., additional, Pierik, Marie J., additional, Ponsioen, Cyriel, additional, van der Meulen – de Jong, Andrea E., additional, van der Woude, Christien J., additional, van de Meeberg, Paul, additional, Romberg-Camps, Mariëlle, additional, Clemens, Cees, additional, Jansen, Jeroen M., additional, Mahmmod, Nofel, additional, Bolwerk, Clemens, additional, Vermeijden, Reinoud, additional, Siersema, Peter D., additional, and Oldenburg, Bas, additional

Published
2014
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47. Su1327 Healthcare Costs and Their Predictors in Inflammatory Bowel Disease: Two Year Results From the COIN study

Author

van der Valk, Mirthe E., primary, Mangen, Marie-Josée Justine, additional, Leenders, Max, additional, Dijkstra, Gerard, additional, Van Bodegraven, Adriaan A., additional, Fidder, Herma, additional, De Jong, Dirk J., additional, Pierik, Marie J., additional, van der Woude, Christien J., additional, Romberg-Camps, Mariëlle, additional, Clemens, Cees, additional, Jansen, Jeroen M., additional, Mahmmod, Nofel, additional, van de Meeberg, Paul, additional, van der Meulen – de Jong, Andrea E., additional, Ponsioen, Cyriel, additional, Bolwerk, Clemens, additional, and Vermeijden, Reinoud, additional

Published
2014
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49. Mo1956 Surveillance for Colorectal Cancer in Colitis Patients: Effect of the Implementation of New British and American Guidelines on Neoplasia Yield

Author

Mooiweer, Erik, primary, van der Meulen – de Jong, Andrea E., additional, van Bodegraven, Adriaan A., additional, Jansen, Jeroen M., additional, Mahmmod, Nofel, additional, Nijsten, Joyce, additional, van Oijen, Martijn G., additional, Siersema, Peter D., additional, and Oldenburg, Bas, additional

Published
2013
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50. Evolution of Costs of Inflammatory Bowel Disease over Two Years of Follow-Up.

Author

van der Valk, Mirthe E., Mangen, Marie-Josée J., Severs, Mirjam, van der Have, Mike, Dijkstra, Gerard, van Bodegraven, Ad A., Fidder, Herma H., de Jong, Dirk J., van der Woude, C. Janneke, Romberg-Camps, Mariëlle J. L., Clemens, Cees H. M., Jansen, Jeroen M., van de Meeberg, Paul C., Mahmmod, Nofel, van der Meulen-de Jong, Andrea E., Ponsioen, Cyriel Y., Bolwerk, Clemens, Vermeijden, J. Reinoud, Siersema, Peter D., and Leenders, Max

Subjects
INFLAMMATORY bowel disease treatment, HOSPITAL costs, TUMOR necrosis factors, CROHN'S disease, ULCERATIVE colitis, FOLLOW-up studies (Medicine)
Abstract

Background: With the increasing use of anti-TNF therapy in inflammatory bowel disease (IBD), a shift of costs has been observed with medication costs replacing hospitalization and surgery as major cost driver. We aimed to explore the evolution of IBD-related costs over two years of follow-up. Methods and Findings: In total 1,307 Crohn's disease (CD) patients and 915 ulcerative colitis (UC) patients were prospectively followed for two years by three-monthly web-based questionnaires. Changes of healthcare costs, productivity costs and out-of-pocket costs over time were assessed using mixed model analysis. Multivariable logistic regression analysis was used to identify costs drivers. In total 737 CD patients and 566 UC were included. Total costs were stable over two years of follow-up, with annual total costs of €7,835 in CD and €3,600 in UC. However, within healthcare costs, the proportion of anti-TNF therapy-related costs increased from 64% to 72% in CD (p<0.01) and from 31% to 39% in UC (p < 0.01). In contrast, the proportion of hospitalization costs decreased from 19% to 13% in CD (p<0.01), and 22% to 15% in UC (p < 0.01). Penetrating disease course predicted an increase of healthcare costs (adjusted odds ratio (adj. OR) 1.95 (95% CI 1.02–3.37) in CD and age <40 years in UC (adj. OR 4.72 (95% CI 1.61–13.86)). Conclusions: BD-related costs remained stable over two years. However, the proportion of anti-TNF-related healthcare costs increased, while hospitalization costs decreased. Factors associated with increased costs were penetrating disease course in CD and age <40 in UC. [ABSTRACT FROM AUTHOR]

Published
2016
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