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1. Effect of empagliflozin on ventricular arrhythmias in patients with type 2 diabetes treated with an implantable cardioverter-defibrillator: the EMPA-ICD trial

Author

Fujiki, Shinya, Iijima, Kenichi, Nakagawa, Yoshihisa, Takahashi, Kazuyoshi, Okabe, Masaaki, Kusano, Kengo, Owada, Shingen, Kondo, Yusuke, Tsujita, Kenichi, Shimizu, Wataru, Tomita, Hirofumi, Watanabe, Masaya, Shoda, Morio, Watanabe, Masafumi, Tokano, Takashi, Murohara, Toyoaki, Kaneshiro, Takashi, Kato, Takeshi, Hayashi, Hidemori, Maemura, Koji, Niwano, Shinichi, Umemoto, Tomio, Yoshida, Hisako, Ota, Keiko, Tanaka, Takahiro, Kitamura, Nobutaka, Node, Koichi, and Minamino, Tohru

Published
2024
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3. External validation of the Pulmonary Embolism-Syncope, Anemia, and Renal Dysfunction bleeding score for early major bleeding in patients with acute pulmonary embolism: from the COMMAND VTE Registry-2

Author

Kaneda, Kazuhisa, Nishikawa, Ryusuke, Yamashita, Yugo, Chatani, Ryuki, Mushiake, Kazunori, Kadota, Kazushige, Nishimoto, Yuji, Sato, Yukihito, Ikeda, Nobutaka, Amemiya, Katsushi, Nakamura, Masato, Kobayashi, Yohei, Kimura, Ren, Inada, Tsukasa, Ikeda, Satoshi, Ueno, Yuki, Maemura, Koji, Kim, Kitae, Shigeno, Ryo, Furukawa, Yutaka, inoko, Moriaki, Ito, Shinya, Takase, Toru, Nakazawa, Gaku, Tsuji, Shuhei, Toyofuku, Mamoru, Oi, Maki, Kaitani, Kazuaki, Takada, Takuma, Jujo, Kentaro, Hagiwara, Nobuhisa, Otsui, Kazunori, Mori, Kenta, Sakamoto, Jiro, Tamura, Toshihiro, Morimoto, Takeshi, Inoko, Moriaki, Ogihara, Yoshito, Inoue, Takeshi, Usami, Shunsuke, Chen, Po-Min, Togi, Kiyonori, Koitabashi, Norimichi, Hiramori, Seiichi, Doi, Kosuke, Mabuchi, Hiroshi, Tsuyuki, Yoshiaki, Murata, Koichiro, Takabayashi, Kensuke, Nakai, Hisato, Sueta, Daisuke, Shioyama, Wataru, Dohke, Tomohiro, Watanabe, Tetsuya, Yamada, Takahisa, Fukunami, Masatake, and Kimura, Takeshi

Published
2024
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5. External validation of the Pulmonary Embolism-Syncope, Anemia, and Renal Dysfunction bleeding score for early major bleeding in patients with acute pulmonary embolism: from the COMMAND VTE Registry-2

Author

Nishimoto, Yuji, Yamashita, Yugo, Morimoto, Takeshi, Chatani, Ryuki, Kaneda, Kazuhisa, Ikeda, Nobutaka, Kobayashi, Yohei, Ikeda, Satoshi, Kim, Kitae, Inoko, Moriaki, Takase, Toru, Tsuji, Shuhei, Oi, Maki, Takada, Takuma, Otsui, Kazunori, Sakamoto, Jiro, Ogihara, Yoshito, Inoue, Takeshi, Usami, Shunsuke, Chen, Po-Min, Togi, Kiyonori, Koitabashi, Norimichi, Hiramori, Seiichi, Doi, Kosuke, Mabuchi, Hiroshi, Tsuyuki, Yoshiaki, Murata, Koichiro, Takabayashi, Kensuke, Nakai, Hisato, Sueta, Daisuke, Shioyama, Wataru, Dohke, Tomohiro, Nishikawa, Ryusuke, Sato, Yukihito, Watanabe, Tetsuya, Yamada, Takahisa, Fukunami, Masatake, Kimura, Takeshi, Kaneda, Kazuhisa, Nishikawa, Ryusuke, Yamashita, Yugo, Chatani, Ryuki, Mushiake, Kazunori, Kadota, Kazushige, Nishimoto, Yuji, Sato, Yukihito, Ikeda, Nobutaka, Amemiya, Katsushi, Nakamura, Masato, Kobayashi, Yohei, Kimura, Ren, Inada, Tsukasa, Ikeda, Satoshi, Ueno, Yuki, Maemura, Koji, Kim, Kitae, Shigeno, Ryo, Furukawa, Yutaka, inoko, Moriaki, Ito, Shinya, Takase, Toru, Nakazawa, Gaku, Tsuji, Shuhei, Toyofuku, Mamoru, Oi, Maki, Kaitani, Kazuaki, Takada, Takuma, Jujo, Kentaro, Hagiwara, Nobuhisa, Otsui, Kazunori, Mori, Kenta, Sakamoto, Jiro, and Tamura, Toshihiro

Abstract

There is no established risk score for anticoagulant-related bleeding during the acute phase in patients with pulmonary embolism (PE). The PE-Syncope, Anemia, and Renal Dysfunction (PE-SARD) bleeding score was developed to predict early major bleeding but has not yet been fully externally validated.

Published
2024
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6. Effects of tafamidis on the left ventricular and left atrial strain in patients with wild-type transthyretin cardiac amyloidosis.

Author

Nishizawa, Rosy Haruna, Kawano, Hiroaki, Yoshimuta, Tsuyoshi, Eguchi, Chisa, Kojima, Sanae, Minami, Takako, Sato, Daisuke, Eguchi, Masamichi, Okano, Shinji, Ikeda, Satoshi, Ueda, Mitsuharu, and Maemura, Koji

Subjects
ATRIAL fibrillation diagnosis, PERIPHERAL neuropathy diagnosis, HETEROCYCLIC compounds, PERIPHERAL neuropathy, CARDIOMYOPATHIES, TREATMENT effectiveness, DESCRIPTIVE statistics, AMYLOID, ATRIAL fibrillation, LEFT ventricular dysfunction, ECHOCARDIOGRAPHY, SERUM albumin, DISEASE complications
Abstract

Aims Although tafamidis is used in patients with wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), its specific effect on cardiac function is unclear. Thus, this study aimed to investigate the effect of tafamidis on left atrial (LA) and left ventricular function using speckle-tracking echocardiography for 1 year of treatment in patients with ATTRwt-CA. Methods and results We included 23 patients (mean age, 76 years) with ATTRwt-CA confirmed via biopsy. We analysed the left ventricular and LA strain using 2D speckle-tracking echocardiography and compared these parameters before and 1 year after starting treatment with tafamidis between 16 patients with sinus rhythm (SR) and 7 patients with atrial fibrillation (AF). In ATTRwt-CA patients with SR, LA reservoir strain significantly improved by 1-year tafamidis treatment (10.5 ± 5.0% to 11.9 ± 5.3%, P = 0.0307) although global longitudinal strain (GLS) did not (−10.6 ± 3.1% to −11.3 ± 3.0%, P = 0.0608). In contrast, LA reservoir strain was not significantly changed (5.4 ± 2.9% to 4.9 ± 1.7%, P = 0.4571), and GLS deteriorated (−8.4 ± 2.3% to −6.8 ± 1.4%, P = 0.0267) in ATTRwt-CA patients with AF. Conclusion LA function improved with tafamidis treatment in ATTRwt-CA patients with SR but not left ventricular function. However, these cardiac functions did not improve with tafamidis treatment in ATTRwt-CA patients with AF. [ABSTRACT FROM AUTHOR]

Published
2024
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7. An Iron-chelating Agent Improved the Cardiac Function in a Patient with Severe Heart Failure Due to Hereditary Hemochromatosis

Author

Setoguchi, Akito, primary, Kawano, Hiroaki, additional, Okano, Shinji, additional, Honda, Tomohiro, additional, Kato, Takeharu, additional, Dateki, Sumito, additional, Senoo, Akira, additional, Nakashima, Yomi, additional, Motokawa, Tetsufumi, additional, Ueno, Yuki, additional, Akashi, Ryohei, additional, Yonekura, Tsuyoshi, additional, Sueyoshi, Eijun, additional, Ikeda, Satoshi, additional, Miyazaki, Yasushi, additional, and Maemura, Koji, additional

Published
2024
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10. Real-world Safety and Effectiveness of Edoxaban in Patients with Venous Thromboembolism with or without Preceding Parenteral Anticoagulants: A Single-center Retrospective Study

Author

Ueno, Yuki, primary, Ikeda, Satoshi, additional, Motokawa, Tetsufumi, additional, Honda, Tomohiro, additional, Kurobe, Masaya, additional, Akashi, Ryohei, additional, Yonekura, Tsuyoshi, additional, Yoshimuta, Tsuyoshi, additional, Eguchi, Masamichi, additional, Kawano, Hiroaki, additional, and Maemura, Koji, additional

Published
2024
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11. The Authors' Reply to "Efficacy and feasibility of edoxaban therapy without prior parenteral anticoagulants in patients with venous thromboembolism"

Author

Ueno, Yuki, primary, Ikeda, Satoshi, additional, Motokawa, Tetsufumi, additional, Honda, Tomohiro, additional, Kurobe, Masaya, additional, Akashi, Ryohei, additional, Yonekura, Tsuyoshi, additional, Yoshimuta, Tsuyoshi, additional, Eguchi, Masamichi, additional, Kawano, Hiroaki, additional, and Maemura, Koji, additional

Published
2024
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14. Ubiquitin, p62, and Microtubule-Associated Protein 1 Light Chain 3 in Cardiomyopathy

Author

Eto, Ryo, primary, Kawano, Hiroaki, additional, Matsuyama-Matsuu, Mutsumi, additional, Matsuda, Katsuya, additional, Ueki, Nozomi, additional, Nakashima, Masahiro, additional, Okano, Shinji, additional, Ishijima, Mitsuaki, additional, Kawakatsu, Miho, additional, Watanabe, Jumpei, additional, Yoshimuta, Tsuyoshi, additional, Ikeda, Satoshi, additional, and Maemura, Koji, additional

Published
2023
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15. Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD‐J B study

Author

Masaki, Nobuyuki, primary, Adachi, Takeshi, additional, Tomiyama, Hirofumi, additional, Kohro, Takahide, additional, Suzuki, Toru, additional, Ishizu, Tomoko, additional, Ueda, Shinichiro, additional, Yamazaki, Tsutomu, additional, Furumoto, Tomoo, additional, Kario, Kazuomi, additional, Inoue, Teruo, additional, Koba, Shinji, additional, Takemoto, Yasuhiko, additional, Hano, Takuzo, additional, Sata, Masataka, additional, Ishibashi, Yutaka, additional, Node, Koichi, additional, Maemura, Koji, additional, Ohya, Yusuke, additional, Furukawa, Taiji, additional, Ito, Hiroshi, additional, Higashi, Yukihito, additional, Yamashina, Akira, additional, and Takase, Bonpei, additional

Published
2023
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19. Successful percutaneous transluminal renal angioplasty with multimodality imaging guidance for a juvenile patient with renovascular hypertension due to fibromuscular dysplasia

Author

Eto, Ryo, Kawano, Hiroaki, Akashi, Ryohei, Ikeda, Satoshi, and Maemura, Koji

Subjects
Case Report, Cardiology and Cardiovascular Medicine
Abstract

Percutaneous transluminal renal angioplasty (PTRA) is an effective treatment for renovascular hypertension due to fibromuscular dysplasia (FMD). PTRA for renovascular FMD is performed with only balloons based on the consensus that stent kinking and fracture have been reported in cases of PTRA using stents for FMD. Therefore, it is important to avoid procedural complications, such as flow-limiting dissection or arterial rupture, in PTRA for renovascular FMD. We present a case of a juvenile patient who presented with renovascular hypertension due to FMD. Angiography revealed focal stenosis of the right renal artery, and the pressure wire showed a resting distal coronary to aortic pressure ratio (Pd/Pa) of 0.83. Intravascular ultrasound (IVUS) showed an intima-media complex that could not be qualitatively assessed. Optical coherence tomography (OCT) showed intimal fibroplasia and medial hyperplasia with areas of low intensity. Based on the OCT images, balloon angioplasty was performed using a semi-compliant balloon. After balloon angioplasty, IVUS and OCT revealed luminal expansion with mild residual stenosis, and the Pd/Pa ratio was 0.99. We decided not to increase the balloon size to avoid vascular injuries. In conclusion, PTRA with only balloon can be safely performed for FMD under the guidance of multimodal imaging, using IVUS, OCT, and a pressure wire. LEARNING OBJECTIVES: This report describes successful percutaneous transluminal renal angioplasty (PTRA) for a juvenile patient with renovascular hypertension due to fibromuscular dysplasia (FMD) under the guidance of multimodal imaging, using intravascular ultrasound (IVUS), optical coherence tomography (OCT), and a pressure wire. When IVUS for FMD cannot assess the culprit lesion qualitatively, OCT could be effective in performing angioplasty with only balloon, without significant vascular injuries. A pressure wire can show the endpoint of PTRA and help avoid increasing the balloon size to prevent significant vascular injuries.

Published
2022

20. Optimizing cardiac amyloidosis assessment: utility of 1-h and 3-h 99mTc-PYP imaging.

Author

Imakhanova, Aiganym, Ideguchi, Reiko, Kawano, Hiroaki, Maemura, Koji, and Kudo, Takashi

Subjects
CARDIAC amyloidosis, STERNUM, HEART failure patients, CARDIAC imaging
Abstract

Background: Transthyretin amyloid cardiomyopathy (ATTR-CM), characterized by the extracellular deposition of an insoluble amyloid protein in the heart, is one of the main causes of heart failure in elderly patients. In this study, our primary objective was to explore the diverse applications and temporal significance of 1-h and 3-h imaging using 99mTc-PYP in the context of ATTR-CM. Additionally, we compared tracer kinetics in the heart and bone to comprehensively assess the diagnostic advantages and time-related considerations associated with these two incubation periods. Methods: Twenty-seven patients at Nagasaki University Hospital who underwent 99mTc-PYP planar, and SPECT cardiac imaging were classified into two groups (ATTR-CM-positive and -negative groups) based on the American Heart Association statement. Cardiac retention was assessed with both a semiquantitative visual score and a quantitative analysis. To assess bone accumulation, a ROI with an equal volume was drawn on the sternum and calculated as the bone-to-contralateral ratio (B/CL). We also evaluated correlation between heart-to-contralateral lung (H/CL) ratio and left ventricular wall thickness. Results: Among patients who underwent 99mTc-PYP imaging, the H/CL ratio was significantly higher at 1 h than at 3 h regardless of the group (from 2.20 ± 0.36 to 1.99 ± 0.35, p < 0.01 in the positive group and from 1.35 ± 0.12 to 1.19 ± 0.21, p = 0.01 in the negative group). The gap of H/CL between highest H/CL of negative case and lowest H/CL of positive case was narrower in 3 h. On the other hand, correlation between H/CL and left ventricular posterior wall thickness tends to be clearer in 3 h (p = 0.12, r = 0.30 for 1 h, p = 0.04, r = 0.39 at 3 h). Conclusion: Our study suggests that both 1-h and 3-h incubation times for 99mTc-PYP imaging have different benefits for ATTR cardiac amyloidosis. A one-hour incubation may be preferable for differential diagnostic purposes, while a three-hour incubation may provide greater utility in evaluating disease severity. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Differential predictive factors for cardiovascular events in patients with or without cancer history

Author

Sueta, Daisuke, Tabata, Noriaki, Ikeda, Satoshi, Saito, Yuichi, Ozaki, Kazuyuki, Sakata, Kenji, Matsumura, Takeshi, Yamamoto-Ibusuki, Mutsuko, Murakami, Yoji, Jodai, Takayuki, Fukushima, Satoshi, Yoshida, Naoya, Kamba, Tomomi, Araki, Eiichi, Iwase, Hirotaka, Fujii, Kazuhiko, Ihn, Hironobu, Kobayashi, Yoshio, Minamino, Tohru, Yamagishi, Masakazu, Maemura, Koji, Baba, Hideo, Matsui, Kunihiko, and Tsujita, Kenichi

Published
2019
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22. Fulminant Myocarditis and Acute Appendicitis after COVID-19 Vaccination

Author

Kawano, Hiroaki, primary, Yamamoto, Nobu, additional, Kurohama, Hirokazu, additional, Okano, Shinji, additional, Kurobe, Masaya, additional, Honda, Tomohiro, additional, Akashi, Ryohei, additional, Yonekura, Tsuyoshi, additional, Ikeda, Satoshi, additional, Izumikawa, Koichi, additional, and Maemura, Koji, additional

Published
2023
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23. Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements : The FMD-J B study

Author

Masaki, Nobuyuki, Adachi, Takeshi, Tomiyama, Hirofumi, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Higashi, Yukihito, Yamashina, Akira, Takase, Bonpei, Masaki, Nobuyuki, Adachi, Takeshi, Tomiyama, Hirofumi, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Higashi, Yukihito, Yamashina, Akira, and Takase, Bonpei

Abstract

Type 2 diabetes mellitus (T2DM) is a major cause of microvascular dysfunction. However, its effect on blood flow patterns during ischemic demand has not been adequately elucidated. In this study, we investigated the hypothesis that microvascular dysfunction in patients with T2DM manifests as brachial reactive hyperemia (BRH), defined as the ratio of peak blood flow velocities in a brachial artery before and after forearm cuff occlusion. The study enrolled 943 subjects (men, n = 152 [T2DM] and n = 371 [non-T2DM]; women, n = 107 [T2DM] and n = 313 [non-T2DM], respectively) with no history of cardiovascular disease. Semiautomatic measurements were obtained three times at 1.5-year intervals to confirm the reproducibility of factors involved in BRH for each sex. An age-adjusted mixed model demonstrated attenuated BRH in the presence of T2DM in both men (p = 0.022) and women (p = 0.031) throughout the study period. Post hoc analysis showed that the estimated BRH was significantly attenuated in patients with T2DM regardless of sex, except at baseline in women. In multivariate regression analysis, T2DM was a negative predictor of BRH at every measurement in men. For women, BRH was more strongly associated with alcohol consumption. Repeated measurements analysis revealed that T2DM was associated with attenuated postocclusion reactive hyperemia.

Published
2023

24. Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M

Author

Abe, Hajime, Takeda, Norihiko, Isagawa, Takayuki, Semba, Hiroaki, Nishimura, Satoshi, Morioka, Masaki Suimye, Nakagama, Yu, Sato, Tatsuyuki, Soma, Katsura, Koyama, Katsuhiro, Wake, Masaki, Katoh, Manami, Asagiri, Masataka, Neugent, Michael L., Kim, Jung-whan, Stockmann, Christian, Yonezawa, Tomo, Inuzuka, Ryo, Hirota, Yasushi, Maemura, Koji, Yamashita, Takeshi, Otsu, Kinya, Manabe, Ichiro, Nagai, Ryozo, and Komuro, Issei

Published
2019
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25. Comparison of Effectiveness and Safety Among 3 Direct Oral Anticoagulants in Patients With Venous Thromboembolism ― A Single-Center Retrospective Study ―

Author

Ueno, Yuki, primary, Ikeda, Satoshi, additional, Motokawa, Tetsufumi, additional, Honda, Tomohiro, additional, Kurobe, Masaya, additional, Akashi, Ryohei, additional, Yonekura, Tsuyoshi, additional, Yoshimuta, Tsuyoshi, additional, Eguchi, Masamichi, additional, Kawano, Hiroaki, additional, and Maemura, Koji, additional

Published
2022
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26. Features and Outcomes of Histologically Proven Myocarditis With Fulminant Presentation

Author

Kanaoka, Koshiro, primary, Onoue, Kenji, additional, Terasaki, Satoshi, additional, Nakano, Tomoya, additional, Nakai, Michikazu, additional, Sumita, Yoko, additional, Hatakeyama, Kinta, additional, Terasaki, Fumio, additional, Kawakami, Rika, additional, Iwanaga, Yoshitaka, additional, Miyamoto, Yoshihiro, additional, Saito, Yoshihiko, additional, Yuda, Satoshi, additional, Tanno, Masaya, additional, Takahashi, Toru, additional, Yokoshiki, Hisashi, additional, Toba, Masahiro, additional, Anzai, Toshihisa, additional, Nagai, Toshiyuki, additional, Sato, Takuma, additional, Takenaka, Takashi, additional, Yamazaki, Seiji, additional, Katagiri, Yuki, additional, Takeuchi, Toshiharu, additional, Sugitatsu, Kazuya, additional, Kakinoki, Shigeo, additional, Matsumoto, Tomoaki, additional, Urasawa, Kazushi, additional, Tan, Michinao, additional, Tsujino, Ichizo, additional, Kamigaki, Mitsunori, additional, Tomita, Hirofumi, additional, Hanada, Kenji, additional, Kushibiki, Motoi, additional, Nakamura, Akihiro, additional, Morino, Yoshihiro, additional, Nasu, Takahito, additional, Yasuda, Satoshi, additional, Suzuki, Hideaki, additional, Iwabuchi, Kaoru, additional, Tsuji, Kanako, additional, Namiuchi, Shigeto, additional, Komaru, Tatsuya, additional, Yagi, Masahiro, additional, Uematsu, Shoko, additional, Takahashi, Toshiaki, additional, Takeda, Satoru, additional, Nakanishi, Toru, additional, Watanabe, Masafumi, additional, Wanezaki, Masahiro, additional, Matsui, Motoyuki, additional, Sugawara, Shigeo, additional, Takeishi, Yasuchika, additional, Oikawa, Masayoshi, additional, Komatsu, Nobuo, additional, Suzuki, Satoshi, additional, Okamoto, Hiroshi, additional, Takeyasu, Noriyuki, additional, Akiyama, Daiki, additional, Eki, Yutaka, additional, Kakuta, Tsunekazu, additional, Sugiyama, Tomoyo, additional, Koizumi, Tomomi, additional, Ueno, Koji, additional, Kario, Kazuomi, additional, Taki, Mizuri, additional, Matsumoto, Yuri, additional, Yasu, Takanori, additional, Nishioka, Osamu, additional, Naito, Shigeto, additional, Murata, Makoto, additional, Tange, Shoichi, additional, Kaneko, Katsumi, additional, Muto, Makoto, additional, Inagaki, Hiroshi, additional, Hasegawa, Shuichi, additional, Tachibana, Eizo, additional, Atsumi, Wataru, additional, Suzuki, Masahiro, additional, Muramatsu, Toshihiro, additional, Yamada, Yoshihiro, additional, Taguchi, Isao, additional, Fukuda, Yoshiaki, additional, Matsui, Akihiro, additional, Kanda, Junji, additional, Hozawa, Koji, additional, Matsumura, Akihiko, additional, Shimizu, Wataru, additional, Yamamoto, Takeshi, additional, Komuro, Issei, additional, Hatano, Masaru, additional, Ikeda, Takanori, additional, Kiuchi, Shunsuke, additional, Chikamori, Taishiro, additional, Takei, Yasuyoshi, additional, Soejima, Kyoko, additional, Minamishima, Toshinori, additional, Tanaka, Hiroyuki, additional, Shimizu, Shigeo, additional, Kasao, Masashi, additional, Kadohira, Tadayuki, additional, Minamino, Tohru, additional, Shimada, Kazunori, additional, Iwata, Hiroshi, additional, Momiyama, Yukihiko, additional, Ashikaga, Takashi, additional, Nozato, Toshihiro, additional, Fujiwara, Yasumasa, additional, Inoue, Kenji, additional, Sasano, Tetsuo, additional, Matsuda, Junji, additional, Ishii, Yasuhiro, additional, Ono, Yuichi, additional, Tanabe, Kengo, additional, Horiuchi, Yu, additional, Shinke, Toshiro, additional, Kodama, Yusuke, additional, Moroi, Masao, additional, Yazaki, Yoshiyuki, additional, Mizumura, Taisuke, additional, Ohta, Hiroshi, additional, Akashi, Yoshihiro, additional, Kotoku, Nozomi, additional, Ikari, Yuji, additional, Maruyama, Mitsunori, additional, Sato, Yasuhiro, additional, Tamura, Koichi, additional, Konishi, Masaaki, additional, Suzuki, Hiroshi, additional, Ebato, Mio, additional, Fukui, Kazuki, additional, Yumoto, Kazuhiko, additional, Iwasawa, Takamasa, additional, Kashimura, Takeshi, additional, Takahashi, Kazuyoshi, additional, Okada, Yoshinobu, additional, Kaku, Bunji, additional, Usuda, Kazuo, additional, Maruyama, Michiro, additional, Kameyama, Tomoki, additional, Higashikata, Toshinori, additional, Hodatsu, Akihiko, additional, Osato, Kazuo, additional, Nagata, Yoji, additional, Maeno, Koji, additional, Satake, Kazuo, additional, Sawanobori, Takao, additional, Watanabe, Noboru, additional, Kuwahara, Koichiro, additional, Motoki, Hirohiko, additional, Kitabayashi, Hiroshi, additional, Otagiri, Kyuhachi, additional, Kono, Tsunesuke, additional, Yamagishi, Daisuke, additional, Yazaki, Yoshikazu, additional, Noda, Toshiyuki, additional, Morishima, Itsuro, additional, Watanabe, Naoki, additional, Tanaka, Shinichiro, additional, Onodera, Tomoya, additional, Nawada, Ryuzo, additional, Watanabe, Akinori, additional, Matsunaga, Masaki, additional, Suwa, Satoru, additional, Sakamoto, Hiroshi, additional, Sakamoto, Hiroki, additional, Aoyama, Takeshi, additional, Kanamori, Norio, additional, Muto, Masahiro, additional, Maekawa, Yuichiro, additional, Ohtani, Hayato, additional, Ozaki, Yukio, additional, Naruse, Kenshin, additional, Takemoto, Kenji, additional, Kamiya, Haruo, additional, Suzuki, Takeshi, additional, Tomita, Yasushi, additional, Suzuki, Susumu, additional, Kametani, Ryosuke, additional, Aoyama, Hidekazu, additional, Osanai, Hiroyuki, additional, Harada, Ken, additional, Kada, Kenji, additional, Saeki, Tomoaki, additional, Kobayashi, Koichi, additional, Ogawa, Yasuhiro, additional, Terasawa, Akihiro, additional, Shinoda, Masanori, additional, Oguri, Mitsutoshi, additional, Shimizu, Kiyokazu, additional, Sawamura, Akinori, additional, Sugiura, Atsushi, additional, Hattori, Kosuke, additional, Mokuno, Shinji, additional, Kondo, Kazuhisa, additional, Dohi, Kaoru, additional, Moriwaki, Keishi, additional, Kasai, Atsunobu, additional, Nakakuki, Tetsuya, additional, Kaitani, Kazuaki, additional, Jinnai, Toshikazu, additional, Yamamoto, Takashi, additional, Kurata, Hiroyuki, additional, Wada, Atsuyuki, additional, Akao, Masaharu, additional, Hamatani, Yasuhiro, additional, Ishibashi, Kazuya, additional, Akakabe, Yoshiki, additional, Asaumi, Yasuhide, additional, Matama, Hideo, additional, Sakata, Yasushi, additional, Kioka, Hidetaka, additional, Takaishi, Hiroshi, additional, Takase, Toru, additional, Matsuda, Mitsuo, additional, Sato, Fumi, additional, Hasegawa, Shinji, additional, Ishigami, Kenichi, additional, Ichikawa, Minoru, additional, Takagi, Takashi, additional, Inoko, Moriaki, additional, Hoshiga, Masaaki, additional, Fujita, Shuichi, additional, Takeda, Yoshihiro, additional, Kawarabayashi, Takahiko, additional, Takaoka, Hideyuki, additional, Nakajima, Kenji, additional, Yuguchi, Tadashi, additional, Kawasaki, Tatsuya, additional, Shinoda, Yukinori, additional, Sato, Yukihito, additional, Ishihara, Masaharu, additional, Matsumoto, Yuki, additional, Kawai, Hiroya, additional, Takaya, Tomofumi, additional, Matsuo, Kouki, additional, Mano, Toshiaki, additional, Hirata, Kenichi, additional, Hisamatsu, Eriko, additional, Inoue, Nobutaka, additional, Tamita, Koichi, additional, Mukohara, Naoki, additional, Shimoyama, Hisashi, additional, Miyajima, Toru, additional, Tamura, Toshihiro, additional, Tamaki, Yodo, additional, Suzuki, Megumi, additional, Yokota, Ryoji, additional, Horii, Manabu, additional, Yamanaka, Kazuo, additional, Kawata, Hiroyuki, additional, Hashimoto, Yukihiro, additional, Nakada, Yasuki, additional, Nakagawa, Hitoshi, additional, Ueda, Tomoya, additional, Nishida, Taku, additional, Seno, Ayako, additional, Watanabe, Makoto, additional, Akasaka, Takashi, additional, Tanimoto, Takashi, additional, Toyofuku, Mamoru, additional, Yamamoto, Kazuhiro, additional, Kinugasa, Yoshiharu, additional, Hirai, Masayuki, additional, Nasu, Hiroshi, additional, Shirota, Kinya, additional, Oda, Tsuyoshi, additional, Oka, Takefumi, additional, Kadota, Kazushige, additional, Ohya, Masanobu, additional, Ito, Hiroshi, additional, Nakamura, Kazufumi, additional, Ogura, Soichiro, additional, Fuke, Soichiro, additional, Uemura, Shiro, additional, Matsubara, Hiromi, additional, Watanabe, Atsuyuki, additional, Morishima, Nobuyuki, additional, Kihara, Yasuki, additional, Hidaka, Takayuki, additional, Ueda, Hironori, additional, Ono, Yujiro, additional, Muraoka, Yuji, additional, Hatanari, Miyo, additional, Miyamoto, Yoshinori, additional, Dote, Keigo, additional, Kato, Masaya, additional, Yano, Masafumi, additional, Mochizuki, Mamoru, additional, Ikeda, Yasuhiro, additional, Fujinaga, Hiroyuki, additional, Hosokawa, Shinobu, additional, Sata, Masataka, additional, Yamaguchi, Koji, additional, Aki, Naoko, additional, Minamino, Tetsuo, additional, Miyake, Yuichi, additional, Takagi, Yuichiro, additional, Doi, Masayuki, additional, Taketani, Yoshio, additional, Okayama, Hideki, additional, Shigematsu, Tatsuya, additional, Higaki, Akinori, additional, Yamaguchi, Osamu, additional, Inaba, Shinji, additional, Ikeda, Shuntaro, additional, Kawai, Kazuya, additional, Kitaoka, Hiroaki, additional, Kubo, Toru, additional, Ando, Kenji, additional, Inui, Kaoru, additional, Fukumoto, Yoshihiro, additional, Hori, Kensuke, additional, Homma, Takehiro, additional, Kawasaki, Tomohiro, additional, Mohri, Masahiro, additional, Fujiwara, Masaki, additional, Tsutsui, Hiroyuki, additional, Ide, Tomomi, additional, Miura, Shin-Ichiro, additional, Kuwano, Takashi, additional, Shimomura, Hideki, additional, Kadokami, Toshiaki, additional, Taba, Masanao, additional, Kondou, Katsuhiro, additional, Kubota, Toru, additional, Nagatomo, Daisuke, additional, Mukai, Yasushi, additional, Matsukawa, Ryuichi, additional, Tashiro, Hideki, additional, Shimomura, Mitsuhiro, additional, Maemura, Koji, additional, Kawano, Hiroaki, additional, Oku, Koji, additional, Yamasa, Toshihiko, additional, Kizaki, Yoshihisa, additional, Sakamoto, Tomohiro, additional, Tamura, Yudai, additional, Ito, Teruhiko, additional, Fujimoto, Kazuteru, additional, Tsujita, Kenichi, additional, Takashio, Seiji, additional, Kurokawa, Hirofumi, additional, Takahashi, Naohiko, additional, Saito, Shotaro, additional, Arikawa, Masaya, additional, Shibata, Yoshisato, additional, Nishihira, Kensaku, additional, Tsuruda, Toshihiro, additional, Sonoda, Masahiro, additional, Atsuchi, Nobuhiko, additional, Ohishi, Mitsuru, additional, Higuchi, Koji, additional, Miyata, Masaaki, additional, Oketani, Naoya, additional, Akimoto, Yoshinori, additional, Asahi, Tomohiro, additional, and Wake, Minoru, additional

Published
2022
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28. Effect of Novel Stratified Lipid Risk by “LDL-Window” and Flow-Mediated Dilation on the Prognosis of Coronary Artery Disease Using the FMD-J Study A Data

Author

Abe, Shichiro, primary, Haruyama, Yasuo, additional, Kobashi, Gen, additional, Toyoda, Shigeru, additional, Inoue, Teruo, additional, Tomiyama, Hirofumi, additional, Ishizu, Tomoko, additional, Kohro, Takahide, additional, Higashi, Yukihito, additional, Takase, Bonpei, additional, Suzuki, Toru, additional, Ueda, Shinichiro, additional, Yamazaki, Tsutomu, additional, Furumoto, Tomoo, additional, Kario, Kazuomi, additional, Koba, Shinji, additional, Takemoto, Yasuhiko, additional, Hano, Takuzo, additional, Sata, Masataka, additional, Ishibashi, Yutaka, additional, Node, Koichi, additional, Maemura, Koji, additional, Ohya, Yusuke, additional, Furukawa, Taiji, additional, Ito, Hiroshi, additional, and Yamashina, Akira, additional

Published
2022
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32. Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study.

Author

Saito, Yuichi, Tanaka, Atsushi, Ishizu, Tomoko, Yoshida, Hisako, Kubota, Yoshiaki, Nanasato, Mamoru, Matsuhisa, Munehide, Ohya, Yusuke, Kobayashi, Yoshio, Node, Koichi, Murohara, Toyoaki, Inoue, Teruo, Sata, Masataka, Ohishi, Mitsuru, Yokote, Kotaro, Kario, Kazuomi, Watada, Hirotaka, Shimomura, Iichiro, Fukumoto, Yoshihiro, and Maemura, Koji

Subjects
CAROTID intima-media thickness, ASYMPTOMATIC patients, CAROTID artery ultrasonography, HYPERURICEMIA, BODY mass index, CAROTID artery, MULTIVARIABLE testing, PROGRESSION-free survival
Abstract

Hyperuricemia is reportedly associated with the progression of carotid intima-media thickness (IMT), a surrogate of cardiovascular risks and events. However, factors associated with carotid IMT progression in patients with asymptomatic hyperuricemia are largely unknown. In this post-hoc analysis of the multicenter, randomized PRIZE study, we analyzed data from a total of 326 patients who underwent carotid ultrasonography in a blind manner at baseline and 24 months to evaluate carotid IMT. Mean and maximum IMT at the common carotid artery (CCA) were measured at a central core laboratory. Factors related to the absolute change in mean and maximum IMT from baseline to 24 months were explored. Overall, the adjusted mean [0.0032 (− 0.0214 to 0.0278) mm] and maximum [0.0011 (− 0.0327 to 0.0351) mm] CCA-IMT increased numerically from baseline to 24 months. Multivariable analysis identified higher body mass index, history of atherosclerotic cardiovascular disease (ASCVD), and lower mean CCA-IMT at baseline as significant factors associated with the increase in mean CCA-IMT. In addition, older age and lower mean CCA-IMT at baseline were significant factors for an increased absolute change in the maximum CCA-IMT at 24 months. The present sub-analysis of the PRIZE study showed higher body mass index, history of ASCVD, and older age as significant factors associated with CCA-IMT progression in patients with asymptomatic hyperuricemia. These factors may be considered when identifying the possible risk of atherosclerotic progression in this specific patient population of hyperuricemia. Trial registration: UMIN000012911 and UMIN000041322. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Right Ventricular Dyssynchrony in Patients With Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Arterial Hypertension

Author

Yamagata, Yuki, primary, Ikeda, Satoshi, additional, Kojima, Sanae, additional, Ueno, Yuki, additional, Nakata, Tomoo, additional, Koga, Seiji, additional, Ohno, Chikara, additional, Yonekura, Tsuyoshi, additional, Yoshimuta, Tsuyoshi, additional, Minami, Takako, additional, Kawano, Hiroaki, additional, and Maemura, Koji, additional

Published
2022
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36. Effects of Vonoprazan on the Antiplatelet Function of Prasugrel Assessed by the VerifyNow P2Y12 Assay in Patients With Coronary Artery Disease

Author

Koga, Seiji, Ikeda, Satoshi, Akashi, Ryohei, Yonekura, Tsuyoshi, Kawano, Hiroaki, and Maemura, Koji

Subjects
Cardiovascular Intervention, Original article, P2Y12 receptors, Proton pump inhibitor, Platelet reactivity, Percutaneous coronary intervention
Abstract

Background: Vonoprazan is a potassium-competitive acid blocker increasingly used in Japan to prevent upper gastrointestinal bleeding in patients undergoing dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). Cytochrome P450 (CYP) 3A4 is involved in the primary metabolism of both vonoprazan and prasugrel. This raises concern about the possibility of a CYP3A4-mediated drug-drug interaction between vonoprazan and prasugrel that may lead to attenuation of prasugrel’s antiplatelet effect. Methods and Results: We evaluated 88 PCI patients who were taking either vonoprazan (n=45) or proton pump inhibitors (PPIs; n=43) in combination with DAPT (aspirin and prasugrel). Platelet reactivity on prasugrel was assessed using the VerifyNow P2Y12 assay. The primary endpoint was comparison of P2Y12 reaction units (PRU) between patients on vonoprazan and PPIs. PRU >208 and

Published
2020

37. Delayed Acute Perimyocarditis and Bilateral Facial Nerve Palsy in a Patient with COVID-19

Author

Matsumura, Kazuki, Kawano, Hiroaki, Kurobe, Masaya, Akashi, Ryohei, Yoshimuta, Tsuyoshi, Ikeda, Satoshi, Ueki, Nozomi, Nakashima, Masahiro, Maemura, Koji, Matsumura, Kazuki, Kawano, Hiroaki, Kurobe, Masaya, Akashi, Ryohei, Yoshimuta, Tsuyoshi, Ikeda, Satoshi, Ueki, Nozomi, Nakashima, Masahiro, and Maemura, Koji

Abstract

A 41-year-old Japanese man was admitted to our hospital with acute perimyocarditis 4 weeks after coronavirus disease 2019 (COVID-19) infection. Ten days after admission, the patient showed bilateral facial nerve palsy in the course of improvement of perimyocarditis under treatment with aspirin and colchicine. After prednisolone therapy, perimyocarditis completely improved, and the facial nerve palsy gradually improved. Acute perimyocarditis and facial nerve palsy can occur even 4 weeks after contracting COVID-19., Internal Medicine, 61 (15), pp. 2327-2332; 2022

Published
2022

38. Fulminant Myocarditis 24 Days after Coronavirus Disease Messenger Ribonucleic Acid Vaccination

Author

Kawano, Hiroaki, Motokawa, Tetsufumi, Kurohama, Hirokazu, Okano, Shinji, Akashi, Ryohei, Yonekura, Tsuyoshi, Ikeda, Satoshi, Izumikawa, Koichi, Maemura, Koji, Kawano, Hiroaki, Motokawa, Tetsufumi, Kurohama, Hirokazu, Okano, Shinji, Akashi, Ryohei, Yonekura, Tsuyoshi, Ikeda, Satoshi, Izumikawa, Koichi, and Maemura, Koji

Abstract

A 60-year-old Japanese woman was hospitalized for cardiogenic shock 24 days after receiving the second dose of the coronavirus disease 2019 BNT162b2 vaccine. Impella CP left ventricular assist device implantation and venoarterial peripheral extracorporeal membranous oxygenation were immediately initiated along with inotropic support and steroid pulse therapy, as an endomyocardial biopsy specimen showed myocarditis. Three weeks later, her cardiac function had recovered, and she was discharged. An immune response associated with the presence of spike protein in cardiac myocytes may be related to myocarditis in the present case because of positive immunostaining for severe acute respiratory syndrome coronavirus 2 spike protein and C4d in the myocardium., Internal Medicine, 61 (15), pp. 2319-2325; 2022

Published
2022

39. Effect of Novel Stratified Lipid Risk by “LDL-Window” and Flow-Mediated Dilation on the Prognosis of Coronary Artery Disease Using the FMD-J Study A Data

Author

Abe, Shichiro, Haruyama, Yasuo, Kobashi, Gen, Toyoda, Shigeru, Inoue, Teruo, Tomiyama, Hirofumi, Ishizu, Tomoko, Kohro, Takahide, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Yamashina, Akira, Abe, Shichiro, Haruyama, Yasuo, Kobashi, Gen, Toyoda, Shigeru, Inoue, Teruo, Tomiyama, Hirofumi, Ishizu, Tomoko, Kohro, Takahide, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, and Yamashina, Akira

Abstract

Background: Elevated levels of triglyceride (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) are regarded as a residual lipid risk in low-density lipoprotein cholesterol (LDL-C)-lowering therapy. This study investigated the association between lipid risk stratified by TG and non-HDL-C and the prognosis of patients with coronary artery disease (CAD), and the association between stratified lipid risk and flow-mediated dilatation (FMD) index. Methods and Results: The 624 CAD patients enrolled in flow-mediated dilation (FMD)-J study A were divided into 4 groups: low-risk group (n=413) with TG <150 mg/dL and non-HDL-C <170 mg/dL; hyper-TG group (n=180) with TG ≥150 mg/dL and non-HDL-C <170 mg/dL; hyper-non-HDL group (n=12) with TG <150 mg/dL and non-HDL-C ≥170 mg/dL; and high-risk group (n=19) with TG ≥150 mg/dL and non-HDL-C ≥170 mg/dL. Comparison of the groups showed the cumulative incidence of a 3-point major adverse cardiovascular event (MACE) was different and highest in the high-risk group in all the patients (P=0.009), and in patients with a FMD index ≥7.0% (P=0.021), but not in those with a FMD index <7.0%. Multivariable regression analysis showed that high lipid risk (P=0.019) and FMD <7.0% (P=0.040) were independently correlated with the incidence of a 3-point MACE. Conclusions: Novel stratification of lipid risk, simply using TG and non-HDL-C levels, combined with FMD measurement, is useful for predicting cardiovascular outcomes in patients with CAD.

Published
2022

40. Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level: FMD-J Study (Flow-Mediated Dilation Japan)

Author

Maruhashi, Tatsuya, Soga, Junko, Fujimura, Noritaka, Idei, Naomi, Mikami, Shinsuke, Iwamoto, Yumiko, Iwamoto, Akimichi, Kajikawa, Masato, Matsumoto, Takeshi, Oda, Nozomu, Kishimoto, Shinji, Matsui, Shogo, Hashimoto, Haruki, Aibara, Yoshiki, Yusoff, Farina Binti Mohamad, Hidaka, Takayuki, Kihara, Yasuki, Chayama, Kazuaki, Noma, Kensuke, Nakashima, Ayumu, Goto, Chikara, Tomiyama, Hirofumi, Takase, Bonpei, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Watanabe, Kentaro, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ikeda, Hisao, Yamashina, Akira, and Higashi, Yukihito

Published
2017
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42. Acute Coronary Syndrome Developed in a 17-year-old Boy with Sitosterolemia Comorbid with Takayasu Arteritis: A Rare Case Report and Review of the Literature

Author

Iyama, Keita, primary, Ikeda, Satoshi, additional, Koga, Seiji, additional, Yoshimuta, Tsuyoshi, additional, Kawano, Hiroaki, additional, Tsuji, Sosuke, additional, Ando, Koji, additional, Matsushima, Kayoko, additional, Tada, Hayato, additional, Kawashiri, Masa-aki, additional, Kawakami, Atsushi, additional, and Maemura, Koji, additional

Published
2022
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44. Japanese Society of Internal Medicine

Author

Izumida, Seiya, Kawano, Hiroaki, Muroya, Takahiro, Motokawa, Tetsufumi, Akashi, Ryohei, Yonekura, Tsuyoshi, Morimoto, Yosuke, Yano, Yudai, Ikeda, Satoshi, and Maemura, Koji

Subjects
nutrition, lipids (amino acids, peptides, and proteins), diet, human activities, cardiopulmonary exercise test
Abstract

Objective Polyunsaturated fatty acids (PUFAs) are associated with heart failure (HF) as well as coronary artery disease. However, little is known about the relationships between PUFAs and the exercise responses of patients with HF. We evaluated the relationships between PUFAs and the parameters of cardiopulmonary exercise tests (CPETs) in patients with non-ischemic HF. Methods Fifty patients with stable non-ischemic HF underwent CPETs at our hospital. Data were analyzed to evaluate the relationships between PUFAs and echocardiographic findings as well as CPET and other test parameters. Results Correlations were significant and negative between dihomo-γ-linolenic acid (DGLA) + arachidonic acid (AA) and minute ventilation versus carbon dioxide production (VE/VCO2) slope, and positive between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and VE/VCO2 slope. A multivariate regression analysis selected DGLA+AA and AA as independent predictors of VE/VCO2 slope. However, eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) were not significantly correlated with the CPET parameters. Conclusion Low levels of circulating DGLA+AA and AA among PUFAs were associated with decreased exercise responses in patients with stable non-ischemic HF. These findings suggest that high levels of omega-6 PUFAs may improve the clinical outcomes of patients with non-ischemic HF via their effects on exercise responses.

Published
2019

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