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12 results on '"Machado, Paulo R.L."'

1. Disseminated Leishmaniasis, a Severe Form of Leishmania braziliensis Infection

Author

Machado, Paulo R.L., Lago, Alexsandro, Cardoso, Thiago M., Magalhaes, Andrea, Carvalho, Lucas P., Lago, Taina, Carvalho, Augusto M., Costa, Rubia, and Carvalho, Edgar M.

Subjects
Leishmaniasis -- Causes of -- Drug therapy -- Patient outcomes, Health
Abstract

Disseminated leishmaniasis (DL) is an aggressive form of tegumentary leishmaniasis associated with multiple and polymorphic cutaneous lesions (acneiform and inflammatory papules, nodules, and ulcers) in [greater than or equal to] [...]

Published
2024
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4. Association of miltefosine with granulocyte and macrophage colony-stimulating factor (GM-CSF) in the treatment of cutaneous leishmaniasis in the Amazon region: A randomized and controlled trial

Author

Mendes, Luciana, Guerra, Jorge Oliveira, Costa, Bleno, Silva, Aríneia Soares da, Guerra, Maria das Graças Barbosa, Ortiz, Jéssica, Doria, Susan Smith, Silva, George Villarouco da, de Jesus, Denison Vital, Barral-Netto, Manoel, Penna, Gerson, Carvalho, Edgar M., and Machado, Paulo R.L.

Published
2021
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6. Comparative study of esketamine and racemic ketamine in treatment-resistant depression: Protocol for a non-inferiority clinical trial

Author

Correia-Melo, Fernanda S., Leal, Gustavo C., Carvalho, Michelle S., Jesus-Nunes, Ana Paula, Ferreira, Carolina B.N., Vieira, Flávia, Magnavita, Guilherme, Vale, Lucas A.S., Mello, Rodrigo P., Nakahira, Carolina, Argolo, Felipe C., Cardoso, Tanise, Souza, Cezar D.S., Fontes, Ana Teresa C., Ferreira, Marcelo B., Araújo-de-Freitas, Lucas, Tuena, Marco A., Echegaray, Mariana V.F., Cavalcanti, Diogo E., Lucchese, Ana C., Bandeira, Igor D., Telles, Manuela, Lima, Cássio S., Sampaio, Aline S., Silva, Samantha S., Marback, Roberta F., Del-Porto, José A., Abreu, José Neander, Sarin, Luciana M., Paixão, Camilla S., Carvalho, Lucas P., Machado, Paulo R.L., Turecki, Gustavo, Lacerda, Acioly L.T., and Quarantini, Lucas C.

Published
2018
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7. Geographic clustering of leishmaniasis in northeastern Brazil

Author

Schriefer, Albert, Guimaraes, Luiz H., Machado, Paulo R.L., Lessa, Marcus, Lessa, Helio A., Lago, Ednaldo, Ritt, Guilherme, Goes-Neto, Aristoteles, Schriefer, Ana L.F., Riley, Lee W., and Carvalho, Edgar M.

Subjects
Southern oscillation -- Health aspects, Leishmaniasis -- Development and progression, Leishmaniasis -- Health aspects, Disease transmission -- Development and progression, Disease transmission -- Health aspects
Abstract

Leishmaniasis accounts for [approximately equal to]2 million disability-adjusted life years in [approximately equal to]90 countries, most of which are in the developing world (1). The past 3 decades have witnessed [...]

Published
2009

8. Cutaneous leishmaniasis during pregnancy: exuberant lesions and potential fetal complications

Author

Morgan, Daniel J., Guimaraes, Luiz H., Machado, Paulo R.L., D'Oliveira, Argemiro Jr., Almeida, Roque P., Lago, Ednaldo L., Faria, Daniela R., Tafuri, Wagner L., Dutra, Walderez O., and Carvalho, Edgar M.

Subjects
Leishmaniasis -- Complications and side effects, Leishmaniasis -- Research, Pregnancy -- Health aspects, Pregnancy, Complications of -- Risk factors, Pregnancy, Complications of -- Research, Health, Health care industry
Published
2007

11. Características da reação tipo 1 e associação com vírus B e C da hepatite na hanseníase

Author

Rego, Vitória P.A., Machado, Paulo R.L., Martins, Isabela, Trindade, Ronald, and Paraná, Raymundo

Subjects
Vírus C, Vírus B, Hepatitis B virus, Hanseníase, Hepatitis C virus, Leprosy, Reação reversa, Episódio reacional tipo 1, Reversal reaction, Type 1 reaction
Abstract

O episódio reacional tipo 1 ou reação reversa é ocorrência inflamatória aguda que atinge a pele e nervos periféricos, encontrada em até 30% dos pacientes com hanseníase, sendo causa comum de incapacidade física. Fatores de risco associados incluem uso de poliquimioterapia e infecções virais. Neste estudo, foram avaliados 620 pacientes com hanseníase. Reação reversa foi diagnosticada em 121 (19,5%) casos, sendo mais freqüente nos indivíduos borderlines (48%). Início da poliquimioterapia foi considerado fator de risco para reação reversa, com 52% dos casos apresentando o primeiro episódio neste momento. Neurite foi documentada em 73% dos casos. A presença de vírus B ou C da hepatite foi documentada em 9% de 55 pacientes com reação reversa e em nenhum dos 57 pacientes sem reação (p = 0, 026; teste exato de Fisher), sugerindo possível papel destes agentes como fatores de risco para desenvolvimento de reação reversa na hanseníase. Type 1 reaction or reversal reaction is an acute inflammatory episode in the skin and peripheral nerves that is found in up to 30% of leprosy patients and commonly causes physical disabilities. Multidrug chemotherapy and viral infections are associated risk factors. In this study, 620 leprosy patients were evaluated. Reversal reactions were diagnosed in 121 cases (19.5%) and were most frequently found in borderline patients (48%). Starting on multidrug chemotherapy was considered to be a risk factor for reversal reaction: 52% of the cases presented their first episode at this time. Neuritis was found in 73% of the cases. The presence of hepatitis B or C virus was documented in 9% of the 55 patients with reversal reaction, while it was not detected in any of the 57 patients without reaction (p = 0.026, Fisher’s exact test). This suggests that these agents may have a role as risk factors for developing reversal reactions.

Published
2007

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