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4. Reconstructive and Aesthetic Surgeries on the Female Genitalia. Guideline of the DGGG, DGPRÄC, OEGGG and SGGG (S2k-Level, AWMF Registry No. 009/019, May 2022)

Author

Beckmann, Matthias W., additional, Borkenhagen, Ada, additional, Fahlbusch, Christine, additional, Gold, Daniela, additional, Hoffmann, Juergen, additional, Löhrs, Bettina, additional, Luze, Hanna, additional, Mirastschijski, Ursula, additional, OʼDey, Dan M., additional, Pöschke, Patrik, additional, Remmel, Eugenia, additional, Schaefer, Dirk, additional, Schulmeyer, Carla E., additional, Schuster, Tobias, additional, Sohn, Michael, additional, von Fritschen, Uwe, additional, and Beier, Justus P., additional

Published
2023
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5. Reconstructive and Aesthetic Surgeries on the Female Genitalia. Guideline of the DGGG, DGPRÄC, OEGGG and SGGG (S2k-Level, AWMF Registry No. 009/019, May 2022)

Author

Beckmann, Matthias W., Borkenhagen, Ada, Fahlbusch, Christine, Gold, Daniela, Hoffmann, Juergen, Löhrs, Bettina, Luze, Hanna, Mirastschijski, Ursula, OʼDey, Dan M., Pöschke, Patrik, Remmel, Eugenia, Schaefer, Dirk, Schulmeyer, Carla E., Schuster, Tobias, Sohn, Michael, von Fritschen, Uwe, and Beier, Justus P.

Abstract

Aim This official guideline was coordinated and published by the German Society for Gynaecology and Obstetrics (DGGG), the German Society for Plastic, Reconstructive and Aesthetic Surgery (DGPRÄC), the Austrian Society for Gynaecology and Obstetrics (OEGGG), and the Swiss Society for Gynaecology and Obstetrics (SGGG). The guideline aims to provide a consensus-based overview of reconstructive and aesthetic surgeries on female genitalia based on an evaluation of the relevant literature. Methods This S2k-guideline was developed by representative members from different medical professions on behalf of the guidelines commission of the DGGG, DGPRÄC, OEGGG and SGGG using a structured consensus process. Recommendations Statements and recommendations on the epidemiology, aetiology, classification, symptoms, diagnosis, and treatment of acquired changes of the external genitalia are presented and special situations are discussed.

Published
2023

6. Radiological Influencing Factors in the Diagnosis of Painful Habitual Instability of the Thumb Basal Joint as a Precursor of Carpometacarpal Arthritis of the Thumb—A Retrospective Study

Author

Winter, Raimund, primary, Hasiba-Pappas, Sophie, additional, Kamolz, Lars-P., additional, Tschauner, Sebastian, additional, Bamer, Oskar, additional, Tuca, Alexandru Cristian, additional, Luze, Hanna, additional, Nischwitz, Sebastian P., additional, Michelitsch, Birgit, additional, Friedl, Herwig, additional, Lumenta, David Benjamin, additional, and Girsch, Werner, additional

Published
2023
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8. Introducing the “SIMline”—A Simulation Course in the Management of Severe Burns as a Tool in Undergraduate Medical Education

Author

Sawetz, Isabel, primary, Hasiba-Pappas, Sophie, additional, Kamolz, Lars-Peter, additional, Holzer-Geissler, Judith C. J., additional, Tuca, Alexandru Cristian, additional, Lumenta, David Benjamin, additional, Wegscheider, Thomas, additional, Luze, Hanna, additional, Nischwitz, Sebastian P., additional, and Winter, Raimund, additional

Published
2023
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11. Suction Drain Volume following Axillary Lymph Node Dissection for Melanoma—When to Remove Drains? A Retrospective Cohort Study

Author

Winter, Raimund, primary, Tuca, Alexandru, additional, Wurzer, Paul, additional, Schaunig, Caroline, additional, Sawetz, Isabelle, additional, Holzer-Geissler, Judith C. J., additional, Gmainer, Daniel Georg, additional, Luze, Hanna, additional, Friedl, Herwig, additional, Richtig, Erika, additional, Kamolz, Lars-Peter, additional, and Lumenta, David Benjamin, additional

Published
2022
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17. Personal protective equipment in the COVID-19 pandemic and the use of cooling-wear as alleviator of thermal stress

Author

Luze, Hanna, Nischwitz, Sebastian P., Kotzbeck, Petra, Fink, Julia, Holzer, Judith C. J., Popp, Daniel, and Kamolz, Lars-Peter

Subjects
Concentration, SARS-CoV-2, COVID-19, Thermal stress, Pilot Projects, General Medicine, Austria, Cooling wear, PPE, Humans, Original Article, Surgery, Plastic, Pandemics, Personal Protective Equipment
Abstract

Summary Background High temperatures at workplaces lead to health-related risks and premature exhaustion. The coronavirus disease 2019 (COVID-19) pandemic requires many health professionals to perform under unfavorable conditions. Personal protective equipment (PPE) causes thermal stress and negatively affects performance. Patients, materials and methods This pilot project investigated the effects of PPE and additional cooling wear on physiological parameters and concentration of six healthy staff members of the Plastic Surgery Department of the Medical University of Graz, Austria during simulated patient care. In this study two 1‑hour cycles with patient care-related tasks with PPE and PPE + cooling-wear, respectively, were conducted. A third cycle with scrubs exclusively served as baseline/negative control. The assessment occurred immediately pre-cycles and post-cycles. Results Pre-cycle assessments showed no significant differences between the cycles. After PPE cycle, increased physical stress levels and decrements in concentration capacity were observed. Physiological parameters were significantly less affected in the cooling cycle, while concentration capacity slightly increased. Conclusion COVID-19 PPE causes considerable thermal stress, ultimately affecting human performance. As opportunity to withstand thermal stress, and improve patients’ and professionals’ safety, cooling-wear can be considered relevant. Medical personnel performing in exceptional situations may particularly benefit from further development and investigation of cooling strategies.

Published
2020

20. Platelet-Rich Plasma in Plastic Surgery: A Systematic Review

Author

Hasiba-Pappas, Sophie K., primary, Tuca, Alexandru Cristian, additional, Luze, Hanna, additional, Nischwitz, Sebastian P., additional, Zrim, Robert, additional, Geißler, Judith C.J., additional, Lumenta, David Benjamin, additional, Kamolz, Lars-P., additional, and Winter, Raimund, additional

Published
2022
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21. The Role of Local Inflammation and Hypoxia in the Formation of Hypertrophic Scars—A New Model in the Duroc Pig.

Author

Nischwitz, Sebastian P., Fink, Julia, Schellnegger, Marlies, Luze, Hanna, Bubalo, Vladimir, Tetyczka, Carolin, Roblegg, Eva, Holecek, Christian, Zacharias, Martin, Kamolz, Lars-Peter, and Kotzbeck, Petra

Subjects
HYPERTROPHIC scars, WOUND healing, HYPOXEMIA, INFLAMMATION, THERAPEUTICS, GENE expression
Abstract

Hypertrophic scars continue to be a major burden, especially after burns. Persistent inflammation during wound healing appears to be the precipitating aspect in pathologic scarring. The lack of a standardized model hinders research from fully elucidating pathophysiology and therapy, as most therapeutic approaches have sparse evidence. The goal of this project was to investigate the mechanisms of scar formation after prolonged wound inflammation and to introduce a method for generating standardized hypertrophic scars by inducing prolonged inflammation. Four wound types were created in Duroc pigs: full-thickness wounds, burn wounds, and both of them with induced hyperinflammation by resiquimod. Clinical assessment (Vancouver Scar Scale), tissue oxygenation by hyperspectral imaging, histologic assessment, and gene expression analysis were performed at various time points during the following five months. Native burn wounds as well as resiquimod-induced full-thickness and burn wounds resulted in more hypertrophic scars than full-thickness wounds. The scar scale showed significantly higher scores in burn- and resiquimod-induced wounds compared with full-thickness wounds as of day 77. These three wound types also showed relative hypoxia compared with uninduced full-thickness wounds in hyperspectral imaging and increased expression of HIF1a levels. The highest number of inflammatory cells was detected in resiquimod-induced full-thickness wounds with histologic features of hypertrophic scars in burn and resiquimod-induced wounds. Gene expression analysis revealed increased inflammation with only moderately altered fibrosis markers. We successfully created hypertrophic scars in the Duroc pig by using different wound etiologies. Inflammation caused by burns or resiquimod induction led to scars similar to human hypertrophic scars. This model may allow for the further investigation of the exact mechanisms of pathological scars, the role of hypoxia and inflammation, and the testing of therapeutic approaches. [ABSTRACT FROM AUTHOR]

Published
2023
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26. The successful use of polylactide wound dressings for chronic lower leg wounds: A retrospective analysis.

Author

Nischwitz, Sebastian P., Popp, Daniel, Shubitidze, David, Luze, Hanna, Zrim, Robert, Klemm, Klaus, Rapp, Matthias, Haller, Herbert L., Feisst, Manuel, and Kamolz, Lars‐Peter

Subjects
TREATMENT of diabetic foot, WOUND healing, RESEARCH, CHRONIC wounds & injuries, RETROSPECTIVE studies, LEG, TREATMENT effectiveness, SURGICAL dressings, BANDAGES & bandaging, LONGITUDINAL method, ADULTS, OLD age
Abstract

Chronic wounds are a challenging medical entity for patients, medical professionals and healthcare systems. Frequently, patients present themselves to wound specialists after months or even years of unsuccessful treatment. Recent developments have resulted in a multitude of different advanced wound dressings created to treat complex, chronic wounds, one of which is the polylactide dressing Suprathel. This study aimed at investigating the healing potential of Suprathel in chronic wounds and differentiating between old and "young", diabetic and non‐diabetic chronic wounds. A prospective, multicentric, non‐controlled intervention study was conducted, treating patients with chronic lower leg ulcers (>3 months) with Suprathel and assessing them weekly. Afterwards, a retrospective analysis was performed analysing the wound size initially, after 4 and after 8 weeks of treatment. Furthermore, a differentiation between diabetic and non‐diabetic, and chronic wounds older and younger than 12 months, was assessed. A significant reduction in wound size was observed in the study population after 8 weeks of treatment. The effect size in the diabetic wound and the old chronic wound group even reached more than one, with the other groups still showing a large effect of the intervention. This study shows that Suprathel is a valuable tool in the armamentarium of a wound specialist. Not only could we show a positive effect on chronic wounds, we could even demonstrate a significant wound size reduction in chronic wounds of old and young, as well as diabetic wounds, with the treatment of older chronic and diabetic wounds yielding an even larger effect size. Further randomised, controlled studies are necessary to show the full potential of advanced wound dressing materials in large patient cohorts. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Mit Mathematik zur Defektdeckung - 62 Jahre Micrografting

Author

Nischwitz, Sebastian P., Luze, Hanna, Holzer, Judith C. J., and Kamolz, Lars-Peter

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Das Mesh-Grafting, als Goldstandard der Defektdeckung kleiner und mittelgroßer Areale, stößt trotz großer Effektivität bei großflächigen Verbrennungen an seine Grenzen. Die theoretisch postulierten Vergrößerungen konnten in der Praxis nachweislich nicht erreicht[zum vollständigen Text gelangen Sie über die oben angegebene URL], 38. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2020)

Published
2020
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29. The impact of resveratrol on skin wound healing, scarring, and aging.

Author

Hecker, Andrzej, Schellnegger, Marlies, Hofmann, Elisabeth, Luze, Hanna, Nischwitz, Sebastian Philipp, Kamolz, Lars‐Peter, and Kotzbeck, Petra

Subjects
WOUND healing, ONLINE information services, CHRONIC wounds & injuries, SCARS, SYSTEMATIC reviews, ANTI-inflammatory agents, RESVERATROL, SKIN aging, MEDLINE
Abstract

Resveratrol is a well‐known antioxidant that harbours many health beneficial properties. Multiple studies associated the antioxidant, anti‐inflammatory, and cell protective effects of resveratrol. These diverse effects of resveratrol are also potentially involved in cutaneous wound healing, scarring, and (photo‐)aging of the skin. Hence, this review highlighted the most relevant studies involving resveratrol in wound healing, scarring, and photo‐aging of the skin. A systematic review was performed and the database PubMed was searched for suitable publications. Only original articles in English that investigated the effects of resveratrol in wound healing, scarring, and (photo‐)aging of the skin were analysed. The literature search yielded a total of 826 studies, but only 41 studies met the inclusion criteria. The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo‐aging of the skin. Resveratrol represents an interesting and promising novel therapy regime but to confirm resveratrol‐associated effects, more evidence based in vitro and in vivo studies are needed. [ABSTRACT FROM AUTHOR]

Published
2022
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