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Your search keyword '"Lumsden, Natalie G."' showing total 11 results
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11 results on '"Lumsden, Natalie G."'

2. Chronic disease IMPACT (chronic disease early detection and improved management in primary care project): An Australian stepped wedge cluster randomised trial

Author

Jones, Julia L, primary, Simons, Koen, additional, Manski-Nankervis, Jo-Anne, additional, Lumsden, Natalie G, additional, Fernando, Sanduni, additional, de Courten, Maximilian P, additional, Cox, Nicholas, additional, Hamblin, Peter Shane, additional, Janus, Edward D, additional, and Nelson, Craig L, additional

Published
2023
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3. Using electronic medical record data to assess chronic kidney disease, type 2 diabetes and cardiovascular disease testing, recognition and management as documented in Australian general practice: a cross-sectional analysis

Author

Jones, Julia L, primary, Lumsden, Natalie G, additional, Simons, Koen, additional, Ta'eed, Anis, additional, de Courten, Maximilian P, additional, Wijeratne, Tissa, additional, Cox, Nicholas, additional, Neil, Christopher J A, additional, Manski-Nankervis, Jo-Anne, additional, Hamblin, Peter Shane, additional, Janus, Edward D, additional, and Nelson, Craig L, additional

Published
2022
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4. Endothelial C-type natriuretic peptide maintains vascular homeostasis

Author

Moyes, Amie J., Khambata, Rayomand S., Villar, Inmaculada, Bubb, Kristen J., Baliga, Reshma S., Lumsden, Natalie G., Xiao, Fang, Gane, Paul J., Rebstock, Anne-Sophie, Worthington, Roberta J., Simone, Michela I., Mota, Filipa, Rivilla, Fernando, Vallejo, Susana, Peiro, Concepcion, Ferrer, Carlos F. Sanchez, Djordjevic, Snezana, Caulfield, Mark J., MacAllister, Raymond J., Selwood, David L., Ahluwalia, Amrita, and Hobbs, Adrian J.

Subjects
Homeostasis -- Health aspects, Endothelium -- Physiological aspects, Natriuretic peptides -- Health aspects, Health care industry
Abstract

The endothelium plays a fundamental role in maintaining vascular homeostasis by releasing factors that regulate local blood flow, systemic blood pressure, and the reactivity of leukocytes and platelets. Accordingly, endothelial dysfunction underpins many cardiovascular diseases, including hypertension, myocardial infarction, and stroke. Herein, we evaluated mice with endothelial- specific deletion of Nppc, which encodes C-type natriuretic peptide (CNP), and determined that this mediator is essential for multiple aspects of vascular regulation. Specifically, disruption of CNP leads to endothelial dysfunction, hypertension, atherogenesis, and aneurysm. Moreover, we identified natriuretic peptide receptor-C (NPR-C) as the cognate receptor that primarily underlies CNP- dependent vasoprotective functions and developed small-molecule NPR-C agonists to target this pathway. Administration of NPR-C agonists promotes a vasorelaxation of isolated resistance arteries and a reduction in blood pressure in wild-type animals that is diminished in mice lacking NPR-C. This work provides a mechanistic explanation for genome-wide association studies that have linked the NPR-C (Npr3) locus with hypertension by demonstrating the importance of CNP/NPR-C signaling in preserving vascular homoeostasis. Furthermore, these results suggest that the CNP/NPR-C pathway has potential as a disease-modifying therapeutic target for cardiovascular disorders., Introduction The vascular endothelium releases an array of vasorelaxant mediators that not only influence the tone and growth of the underlying smooth muscle, but also regulate the reactivity of leukocytes [...]

Published
2014
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