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Continued gambling despite negative consequences, commonly known as ‘chasing’, is a defining feature of disordered gambling. Yet chasing is also a complex and multi-faceted behavioural phenotype; for example, gamblers may chase winning outcomes as well as losses. This study characterized between-session chasing behavior in a large naturalistic dataset of online gambling data, comprising 1,909,681 eCasino sessions played by 15,544 individuals on PlayNow.com, the provincial online gambling platform in British Columbia, Canada. Analyses distinguished sessions on slot machines (as the reference category), blackjack, roulette, video poker, probability games, or mixed sessions. Overall, gamblers returned more slowly after losing sessions, and more quickly after winning sessions, across most product categories. For every standard deviation increase in the prior session net loss, slot machine gamblers took 8.59% longer to return to the website (b = 0.08, p < .001). For every standard deviation increase in the prior session net win, slot machine gamblers returned 6.68% faster (b = -0.07, p < .001). Loss chasing intensities in blackjack, probability, video poker, and mixed sessions did not differ significantly from slot machine sessions, but roulette was associated with a shorter interval to return (b = -0.13, p < .001). Similarly, win chasing intensities across blackjack, probability games, and video poker did not differ significantly from slot machine sessions, but roulette (b = -0.08, p < .001) and mixed (b = -0.02, p = 0.009) sessions were associated with shorter intervals to return. Average behavioural patterns provide limited evidence for loss chasing in the interval between sessions, but gamblers return faster after larger wins. Although slot machines are commonly considered as high-risk gambling products, in our analyses online roulette was associated with the greatest chasing intensities.

The Pathways Model of problem gambling has become a highly influential framework in the field of gambling studies. This special issue commemorates 20 years since the publication of the original paper, highlighting the sustained impact of the Pathways Model across the broader and emergent field of behavioral addictions. As a framework, the Pathways Model set out two distinct objectives: first, to synthesize an array of risk factors and psychological processes that have been implicated in the etiology of gambling problems, and second, to characterize heterogeneity among people with gambling problems. As the articles included in this collection confirm, the three subtypes proposed by Blaszczynski & Nower continue to be an especially powerful stimulus for research.

Open science refers to a set of practices that aim to make scientific research more transparent, accessible, and reproducible, including pre-registration of study protocols, sharing of data and materials, the use of transparent research methods, and open access publishing. In this opinion piece, we describe and evaluate the current state of open science practices in behavioral addiction research. We highlight the specific value of open science practices for the field; discuss recent field-specific meta-scientific reviews that show the adoption of such practices remains in its infancy; address the challenges to engaging with open science; and make recommendations for how researchers, journals, and scientific institutions can work to overcome these challenges and promote high-quality, transparently reported behavioral addiction research. By collaboratively promoting open science practices, the field can create a more sustainable and productive research environment that benefits both the scientificcommunity and society as a whole.

Advances in cashless technologies create a dilemma for gambling regulators. Research indicates that cash purchases entail a ‘pain of paying’ that is attenuated with more abstract forms of payment, yet limited research has directly tested the impact of mode of payment on gambling behavior. Across two experiments, community-recruited gamblers were randomized to use an authentic slot machine in the laboratory, under different conditions of monetary endowment. In Experiment 1 (n = 61), participants were endowed with funds to play the slot machine, in either a cash or voucher format. In Experiment 2 (n = 48), participants acquired the cash endowment as a windfall or from an earning task. In session-level analyses, bet size and bet volume did not vary as a function of monetary condition. In more sensitive trial-level analyses, no interactions involving the monetary manipulations were consistent across the two experiments. Data from both experiments indicated faster spin initiation latencies as a function of losing streak length, and slower spin initiation latencies and larger bet size as a function of the prior win magnitude. These trial-level analyses show systematic influences on gambling behavior in the laboratory environment, supporting the basic sensitivity of our design. Overall, our data provide weak evidence for the hypothesis that monetary factors influence gambling tendencies. Acknowledging the possibility of the null hypothesis, these data also highlight the methodological challenges with manipulating monetary value in gambling research, including the use of endowed funds, and controlling for sources of variability when using authentic slot machines.

Drawing on literature linking bipolar disorder to both creativity and heightened motivation, our aim was to examine whether heightened motivation might contribute to creativity in those with and without bipolar disorder. To examine this, we recruited persons diagnosed with bipolar disorder (n = 49), and persons with no diagnosis of bipolar disorder (n = 37), with over-sampling of those from creative occupations. We gathered measures of lifetime creative accomplishment (Creative Accomplishment Questionnaire), willingness to persist as a creativity task became increasingly difficult (the Compound Remote Associates task) divergent thinking (Unusual Uses Test), self-rated high ambitions (The Willingly Approached Set of Statistically Unlikely Pursuits scale)) and a behavioral measure of willingness to exert physical effort for reward (the Effort Discounting Task). In multiple linear regression models controlling for age and examining the unique effects of the motivation variables, two behavioral indicators from the Effort Discounting task related to creativity. That is, insensitivity to the level of effort required related to higher lifetime creative accomplishment. Insensitivity to the level of reward that could be obtained correlated with more willingness to persist on the creativity task and was higher in the bipolar group than the control comparison group. In sum, effort-based decision-making was related to bipolar disorder, to lifetime creative accomplishment, and to performance on a difficult creativity task. As such, this work contributes to a growing body of research on the role of motivation in creativity. Limitations are discussed.

E. J. Langer's paper, 'The illusion of control' (1975), showed that people act in ways that suggest they hold illusory beliefs in their ability to control the outcome of chance-determined games. This highly cited paper influenced the emerging field of gambling studies, and became a building block for cognitive approaches to problem gambling. Over time, this work has inspired therapeutic approaches based on cognitive restructuring, preventative programmes focused upon gambling myths and regulatory scrutiny of skill mechanics in modern gambling products. However, the psychological mechanisms underlying the 'illusion of control' remain elusive.

Influential learning-based accounts of substance addictions posit the attribution of incentive salience to drug-associated cues, and its escalation by the direct dopaminergic effects of drugs. In translating this account to disordered gambling, we have noted how the intermittent nature of monetary rewards in gambling (i.e. the variable ratio) may allow for analogous learning processes, via effects on dopaminergic signalling. The aim of the present article is to consider how multiple sources of reward variability operate within modern gambling products, and how similar sources of variability, as well as some novel sources of variability, also apply to other digital products implicated in behavioural addictions, including gaming, shopping, social media and online pornography. Online access to these activities facilitates not only unparalleled accessibility but also introduces novel forms of reward variability, as seen in the effects of infinite scrolls and personalized recommendations. We use the term uncertainty to refer to the subjective experience of reward variability. We further highlight two psychological factors that appear to moderate the effects of uncertainty: 1) the timecourse of uncertainty, especially with regard to its resolution, 2) the frequency of exposure, allowing temporal compression. Collectively, the evidence illustrates how qualitative and quantitative variability of reward can confer addictive potential to non-drug reinforcers by exploiting the psychological and neural processes that rely on predictability to guide reward seeking behaviour.

Objective Schizotypal personality (schizotypy) is a cluster of traits in the general population, including alterations in belief formation that may underpin delusional thinking. The psychological processes described by schizotypy could also fuel cognitive distortions in the context of gambling. This study sought to characterize the relationships between schizotypy, gambling-related cognitive distortions, and levels of problem gambling. Methods Analyses were conducted on three groups, a student sample (n = 104) with minimal self-reported gambling involvement, a crowdsourced sample of regular gamblers (via MTurk; n = 277), and an additional crowdsourced sample with a range of gambling involvement (via MTurk; n = 144). Primary measures included the Schizotypal Personality Questionnaire – Brief (SPQ-B), the Peters et al. Delusions Inventory (PDI-21), the Gambling Related Cognitions Scale (GRCS), and the Problem Gambling Severity Index (PGSI). Luck was measured with either the Belief in Good Luck Scale (BIGLS) or the Beliefs Around Luck Scale (BALS). Results Small-to-moderate associations were detected between the components of schizotypy, including delusion proneness, and the gambling-related variables. Schizotypy was associated with the general belief in luck and bad luck, but not beliefs in good luck. A series of partial correlations demonstrated that when the GRCS was controlled for, the relationship between schizotypy and problem gambling was attenuated. Conclusions This study demonstrates that schizotypy is a small-to-moderate correlate of erroneous gambling beliefs and PG. These data help characterize clinical comorbidities between the schizotypal spectrum and problem gambling, and point to shared biases relating to belief formation and decision-making under chance.

Background and aimsThe Conceptual Framework of Harmful Gambling moves beyond a symptoms-based view of harm and addresses a broad set of factors related to the risks and effects of gambling harmfully at the individual, family, and community levels. Coauthored by international research experts and informed by multiple stakeholders, Gambling Research Exchange (GREO) facilitated the framework development in 2013 and retains responsibility for regular updates and mobilization. This review article presents information about the revised version of the Conceptual Framework of Harmful Gambling completed in late 2018.MethodsWe describe eight interrelated factors depicted in the framework that represent major themes in gambling ranging from the specific (gambling environment, exposure, gambling types, and treatment resources) to the general (cultural, social, psychological, and biological influences). After outlining the framework development and collaborative process, we highlight new topics for the recent update that reflect changes in the gambling landscape and prominent discourses in the scientific community. Some of these topics include social and economic impacts of gambling, and a new model of understanding gambling related harm.Discussion and conclusionsWe address the relevance of the CFHG to the gambling and behavioral addictions research community. Harm-based frameworks have been undertaken in other areas of addiction that can both inform and be informed by a model dedicated to harmful gambling. Further, the framework brings a multi-disciplinary perspective to bear on antecedents and factors that co-occur with harmful gambling.

Cross-sectional studies have established a robust correlational link between loot box engagement and problem gambling, but the causal connections are unknown. This longitudinal study tested for ‘migration’ from loot box use to gambling initiation 6-months later. A sample of gamers (aged 18-25) was stratified into two subgroups at baseline: 415 non-gamblers and 221 gamblers. Self-reported engagement with video game microtransactions distinguished loot boxes and ‘direct purchase’ microtransactions (DPMs). Loot box expenditure and the Risky Loot Box Index (RLI) were tested as predictors of gambling initiation and spend at follow-up. At baseline, gamblers spent significantly more than non-gamblers on microtransactions. Among baseline non-gamblers, loot box expenditure and RLI predicted gambling initiation (logistic regressions) and later gambling spending (linear regressions). DPM expenditure did not predict gambling initiation or spend, underscoring the key role of randomized rewards. Exploratory analyses tested whether baseline gambling predicted loot box consumption (the ‘reverse pathway’): among loot box non-users, gambling-related cognitive distortions predicted subsequent loot box expenditure. These data provide empirical evidence for a migration from loot boxes to gambling. Preliminary evidence is also provided for a reverse pathway, of loot box initiation by gamblers. These findings support regulatory steps directed toward young gamers and those who gamble.

The incentive sensitization theory of addiction proposes that through repeated associations with addictive rewards, addiction-related stimuli acquire a disproportionately powerful motivational pull on behaviour. Animal research suggests trait-like individual variation in the degree of incentive salience attribution to reward-predictive cues, defined phenotypically as sign-tracking (high) and goal-tracking (low incentive salience attribution). While these phenotypes have been linked to addiction features in rodents, their translational validity has been little studied. Here, we examined whether sign- and goal-tracking in healthy human volunteers modulates the effects of reward-paired cues on cost-benefit decision making. Sign-tracking was measured in a Pavlovian conditioning paradigm as the amount of eye gaze fixation on the reward-predictive cue versus the location of impending reward delivery. In Study 1 (Cherkasova et al, 2018), participants were randomly assigned to perform a two-choice lottery task in which rewards were either accompanied (cued, n=63) or unaccompanied (uncued, n=68) by money images and casino jingles. In Study 2, participants (n=58) performed cued and uncued versions of the task in a within-subjects design. Across both studies, cues promoted riskier choice, and both studies yielded evidence of goal-tracking being associated with greater risk-promoting effects of cues. These findings are at odds with the notion of sign-trackers being preferentially susceptible to the influence of reward cues on behavior and point to the role of mechanisms besides incentive salience in mediating such influences.

Funder: Gates Cambridge Trust; doi: https://doi.org/10.13039/501100005370, Funder: DH | National Institute for Health Research (NIHR); doi: https://doi.org/10.13039/501100000272, Serotonin is involved in updating responses to changing environmental circumstances. Optimising behaviour to maximise reward and minimise punishment may require shifting strategies upon encountering new situations. Likewise, autonomic responses to threats are critical for survival yet must be modified as danger shifts from one source to another. Whilst numerous psychiatric disorders are characterised by behavioural and autonomic inflexibility, few studies have examined the contribution of serotonin in humans. We modelled both processes, respectively, in two independent experiments (N = 97). Experiment 1 assessed instrumental (stimulus-response-outcome) reversal learning whereby individuals learned through trial and error which action was most optimal for obtaining reward or avoiding punishment initially, and the contingencies subsequently reversed serially. Experiment 2 examined Pavlovian (stimulus-outcome) reversal learning assessed by the skin conductance response: one innately threatening stimulus predicted receipt of an uncomfortable electric shock and another did not; these contingencies swapped in a reversal phase. Upon depleting the serotonin precursor tryptophan-in a double-blind randomised placebo-controlled design-healthy volunteers showed impairments in updating both actions and autonomic responses to reflect changing contingencies. Reversal deficits in each domain, furthermore, were correlated with the extent of tryptophan depletion. Initial Pavlovian conditioning, moreover, which involved innately threatening stimuli, was potentiated by depletion. These results translate findings in experimental animals to humans and have implications for the neurochemical basis of cognitive inflexibility.

Rationale: \ud Gambling and alcohol use are recreational behaviours that share substantial commonalities at a phenomenological, clinical, and neurobiological level. Past studies have shown that alcohol can have a disinhibiting effect on gambling behaviour, in terms of bet size and persistence. \ud Objectives: \ud To characterize how alcohol affects biases in judgment and decision-making that occur during gambling, with a focus on sequential decision-making including the gambler’s fallacy. \ud Methods: \ud Sequential biases were elicited via a roulette-based gambling task. Using a standard between-groups alcohol challenge procedure, male participants played the roulette task 20 minutes after receiving an alcoholic (0.8g/kg; n = 22) or placebo (n = 16) beverage. The task measured colour choice decisions (red/black) and bet size, in response to varying lengths of colour runs and winning/losing feedback streaks.\ud Results: \ud Across both groups, a number of established sequential biases were observed. On colour choice, there was an effect of run length in line with the gambler’s fallacy, which further varied by previous feedback (wins vs losses). Bet size increased with feedback streaks, especially for losing streaks. Compared to placebo, the alcohol group placed higher bets following losses compared to wins. \ud Conclusions: \ud Increased bet size after losses following alcohol consumption may reflect increased loss chasing that may amplify gambling harms. Our results do not fit a simple pattern of enhanced gambling distortions or reward sensitivity, but help contextualize the effects of alcohol on gambling to research on decision-making biases.

Background The prefrontal cortex regulates behavioural adaptation in response to feedback. However, the causal role of different prefrontal regions remains unclear, based on indirect evidence derived from functional neuroimaging. Neuroimaging studies show dorsomedial prefrontal activation during feedback monitoring, whereas the ventrolateral prefrontal cortex engages during behavioural adaptation (shifting). Objective We used high-definition transcranial direct current stimulation (HD-tDCS) to elucidate the roles of the ventrolateral prefrontal cortex (vlPFC) and the dorsomedial prefrontal cortex (dmPFC) in behaviour change, using a probabilistic reversal learning task (PRLT). Method Fifty-two healthy adults were randomly assigned to receive cathodal HD-tDCS to inhibit the vlPFC or the dmPFC versus sham stimulation, prior to completing the PRLT. The outcome measures were the number of perseverative errors and the electroencephalography (EEG) signals of feedback-related negativity (FRN) in the PRLT. We hypothesised that inhibition of the vlPFC would be specifically associated with more perseverative errors and weaker FRNs. Results We found that vlPFC inhibition was associated with higher perseverative errors compared to sham and dmPFC stimulation conditions. Although there were no statistically significant differences in FRN amplitudes, the effect sizes indicate an association between inhibition of the vlPFC and lower FRN amplitudes. Conclusion Our findings support a causal role of the vlPFC on feedback-based behavioural adaptation, which is critical for adaptive goal-driven behaviour.

Concerns regarding the similarities between video game 'loot boxes' and gambling have been supported by correlations in survey studies between loot box engagement and problem gambling scores. It is generally noted that this correlation could reflect loot box users migrating to conventional gambling, and/or people with gambling problems being attracted to loot boxes when they play video games. We describe a third possibility, that when gamers complete problem gambling screens they may be referring to harms incurred from their loot box use. Using three secondary datasets from cross-sectional online surveys, we explore this account in two ways. First, in participants who do not endorse any participation in conventional forms of gambling, we compare rates of positive (i.e. non-zero) scores on the Problem Gambling Severity Index (PGSI) in participants with and without loot box use. Second, noting that some PGSI items have less relevance to loot box use versus gambling, we compare endorsement rates of individual PGSI items, in gamers versus gamblers, and loot box users vs non-loot box users (focusing on item 3 "going back another day to win back the money you lost"). In analysis 1, positive PGSI scorers among non-gamblers were significantly elevated in loot box users vs non-loot box users, although absolute numbers were low overall. In analysis 2, there were no reliable differences (gamers vs gamblers, loot box users vs non-loot box users) in PGSI item 3 endorsement rates. We conclude that these results provide partial support for this third option, and highlight a need for future studies to consider this possibility more directly.

Gambling involves monetary bets and prizes, but the money can take a range of formats, including cash, chips, ticket-in ticket-out vouchers, and digital options including banking cards. As societies move towards cashless payment for many goods, the question arises of how emerging payment technologies might impact gambling related harms. We performed a scoping review following PRISMA guidelines to identify research testing the effects of monetary format in gambling. Our eligibility criteria focused on controlled experimental manipulations, to best establish the causal impact of monetary format. We sought to characterize different types of monetary manipulations that have been studied in a gambling context. We identified 15 eligible articles, comprising 18 individual experiments. These experiments were organized according to four distinct manipulations. The most common design (11 experiments), compared gambling under the presence or absence of money. Smaller numbers of experiments were identified manipulating monetary salience, testing Responsible Gambling tools, and testing the impact of promotional inducements. We identified no studies that compared gambling using cash against alternative payment forms. Our review highlights a paucity of research testing the possible impact of digital and cashless payment options on gambling related harms, using experimental designs that would permit causal conclusions to be drawn.

Aims: Money is central to psychological definitions of gambling, but contemporary accounts of disordered gambling are ambiguous regarding the role of financial motives for gambling. The aims of the current research were to obtain meta-analytic weighted effect sizes for zero-order associations of financial motives against disordered gambling and gambling frequency, as well as partial associations after controlling for other motives (e.g. coping). Design: A meta-analysis of the available literature through October 2019 was undertaken. Studies were identified from multiple sources (e.g., database search, consulting other researchers). PRISMA standards were followed when screening identified records and extracting relevant data. The data analytic plan was pre-registered. Setting: Cross-sectional studies that involved student, community, and clinical samples ofpeople who gamble. Participants: Forty-one studies were included with 32,997 participants from different countries. Measurements: Validated self-report measures of financial motives for gambling alongside measures of either problem gambling and/or gambling frequency. Findings: Financial motives for gambling were positively associated with both disordered gambling, r = .34, [.30, .38], p =1.04e-61, and gambling frequency, r = .29, [.20, .37], p = 1.70e-13, with moderate effect sizes. The partial associations after controlling for overlapping variance with other gambling motives were also positive (disordered gambling: β = .18, [.14, .23], p = 2.53e-15; gambling frequency: β = .16, [.08, .24], p = 9.45e-5), with small-to-moderate effect sizes. The effect sizes were heterogenous and the extent of heterogeneity was high. Moderator analyses of the zero-order association involving gambling frequency indicated that effect sizes were larger for studies that used the Gambling Motives Questionnaire-Financial relative to studies that developed their own gambling motives measure. No further moderators were statistically significant. Conclusions: Financial motives are reliably and positively associated with both disordered gambling and gambling involvement and should be incorporated into etiological models of gambling disorder.

Background and aims Money is central to psychological definitions of gambling, but contemporary accounts are ambiguous regarding the role of financial motives in disordered gambling. The aims of the current research were to obtain meta-analytic weighted effect sizes for zero-order associations of financial motives against gambling frequency and level of problem gambling, as well as partial associations after controlling for other motives (e.g. coping). Methods A meta-analysis of the literature through February 2021 was undertaken. Studies were identified from multiple sources (e.g. database search, other researchers). PRISMA standards were followed when screening identified records and extracting relevant data. The data analytic plan was pre-registered. We included 44 cross-sectional studies that involved student, community and clinical samples of people who gamble (sample sizes ranged from 22-5666), using validated self-report measures of financial gambling motives alongside measures of either gambling frequency and/or problem gambling. Results Financial gambling motives were positively associated with gambling frequency, r = 0.29, 95% CI = [0.21, 0.37], n = 22 738, and level of problem gambling, r = 0.35, 95% CI = [0.31, 0.38], n = 38 204, with moderate effect sizes. Partial associations after controlling for overlapping variance with other gambling motives were also positive (gambling frequency: β = 0.14, 95% CI = [0.05, 0.22], n = 13 844; level of problem gambling: β = 0.18, 95% CI = [0.13, 0.22], n = 28 146), with small-to-moderate effect sizes. Effect sizes were heterogeneous and the extent of heterogeneity was high. Analyses of the zero-order association involving gambling frequency indicated that gambling motives measure (greater for Gambling Motives Questionnaire-Financial) and sample mean age (greater for younger samples) were moderators. No other moderators were statistically significant. Conclusions Financial gambling motives appear to be reliably and positively associated with both gambling frequency and level of problem gambling.

The COVID-19 pandemic triggered the closure of licensed casinos throughout the United States of America in March and April 2020. This study sought to examine how Americans who gamble responded to the COVID-19 lockdown, including migration to online gambling, and changes in substance use and use of other technologies. On 9 April 2020, we recruited an online sample of 424 Americans who gambled in the last three months via Amazon’s Mechanical Turk. Self-reported changes in online gambling and other addictive behaviors since the onset of COVID-19 and problem gambling severity were measured. Overall, online gambling decreased following the onset of COVID-19 casino closures, while alcohol, tobacco, and cannabis use increased. Among respondents who reported no online gambling involvement prior to COVID-19, 15% reported migrating to online gambling. These migrators had higher levels of problem gambling and lower income than respondents who had never gambled online. The response to COVID-19 is heterogeneous: the majority of people who gamble reported reducing their online gambling but increased their substance use. A minority of people who gamble substituted casino gambling with online gambling. Because these individuals are characterized by problem gambling symptoms and lower income, they may be considered a vulnerable group.

Background and aimsIndividuals with gambling disorder display increased levels of risk-taking, but it is not known if it is associated with an altered subjective valuation of gains and/or losses, perception of their probabilities, or integration of these sources of information into expected value.MethodsParticipants with gambling disorder (n = 48) were compared with a healthy comparison group (n = 35) on a two-choice lottery task that involved either gains-only or losses-only gambles. On each trial, two lotteries were displayed, showing the associated probability and magnitude of the possible outcome for each. On each trial, participants chose one of the two lotteries, and the outcome was revealed.ResultsChoice behaviour was highly sensitive to the expected value of the two gambles in both the gain and loss domains. This sensitivity to expected value was attenuated in the group with gambling disorder. The group with gambling disorder used both probability and magnitude information less, and this impairment was greater for probability information. By contrast, they used prior feedback (win vs loss) to inform their next choice, despite the independence of each trial. Within the gambling disorder group, problem gambling severity and trait gambling-related cognitions independently predicted reduced sensitivity to expected value. The majority of observed effects were consistent across both gain and loss domains.Discussion and ConclusionsOur results provide a thorough characterization of decision processes in gain and loss domains in gambling disorder, and place these problems in the context of theoretical constructs from behavioural economics.

Serotonin is involved in updating responses to changing environmental circumstances. Optimising behaviour to maximise reward and minimise punishment may require shifting strategies upon encountering new situations. Likewise, autonomic responses to threats are critical for survival yet must be modified as danger shifts from one source to another. Whilst numerous psychiatric disorders are characterised by behavioural and autonomic inflexibility, few studies have examined the contribution of serotonin in humans. We modelled both processes, respectively, in two independent experiments (N = 97). Experiment 1 assessed instrumental (stimulus-response-outcome) reversal learning whereby individuals learned through trial and error which action was most optimal for obtaining reward or avoiding punishment initially, and the contingencies subsequently reversed serially. Experiment 2 examined Pavlovian (stimulus-outcome) reversal learning assessed by the skin conductance response: one innately threatening stimulus predicted receipt of an uncomfortable electric shock and another did not; these contingencies swapped in a reversal phase. Upon depleting the serotonin precursor tryptophan—in a double-blind randomised placebo-controlled design—healthy volunteers showed impairments in updating both actions and autonomic responses to reflect changing contingencies. Reversal deficits in each domain, furthermore, were correlated with the extent of tryptophan depletion. Initial Pavlovian conditioning, moreover, which involved innately threatening stimuli, was potentiated by depletion. These results translate findings in experimental animals to humans and have implications for the neurochemical basis of cognitive inflexibility.

Reward-related stimuli can potently influence behavior; for example, exposure to drug-paired cues can trigger drug use and relapse in people with addictions. Psychological mechanisms that generate such outcomes likely include cue-induced cravings and attentional biases. Recent animal data suggest another candidate mechanism: reward-paired cues can enhance risky decision making, yet whether this translates to humans is unknown. Here, we examined whether sensory reward-paired cues alter decision making under uncertainty and risk, as measured respectively by the Iowa Gambling Task and a two-choice lottery task. In the cued versions of both tasks, gain feedback was augmented with reward-concurrent audiovisual stimuli. Healthy human volunteers (53 males, 78 females) performed each task once, one with and the other without cues (cued Iowa Gambling Task/uncued Vancouver Gambling Task:n= 63; uncued Iowa Gambling Task/cued Vancouver Gambling Task:n= 68), with concurrent eye-tracking. Reward-paired cues did not affect choice on the Iowa Gambling Task. On the two-choice lottery task, the cued group displayed riskier choice and reduced sensitivity to probability information. The cued condition was associated with reduced eye fixations on probability information shown on the screen and greater pupil dilation related to decision and reward anticipation. This pupil effect was unrelated to the risk-promoting effects of cues: the degree of pupil dilation for risky versus risk-averse choices did not differ as a function of cues. Together, our data show that sensory reward cues can promote riskier decisions and have additional and distinct effects on arousal.SIGNIFICANCE STATEMENTAnimal data suggest that reward-paired cues can promote maladaptive reward-seeking by biasing cost-benefit decision making. Whether this finding translates to humans is unknown. We examined the effects of salient reward-paired audiovisual cues on decision making under risk and uncertainty in human volunteers. Cues had risk-promoting effects on a risky choice task and independently increased task-related arousal as measured by pupil dilation. By demonstrating risk-promoting effects of cues in human participants, our data identify a mechanism whereby cue reactivity could translate into maladaptive behavioral outcomes in people with addictions.

Experimental studies examining the relationship between alcohol use and gambling have focused predominantly on alcohol's influence on gambling behavior. There has been little consideration of the reverse pathway: whether gambling influences subsequent alcohol use. Two experiments examined whether gambling and gambling outcomes (i.e. profits during a gambling session) influenced subsequent alcohol consumption. Experiment 1 (n = 53) used an ad libitum consumption test, in which participants could request beverages during a 30 min window. Experiment 2 (n = 29) used a beer taste test procedure, in which participants were asked to rate a series of beers. In both studies, male regular gamblers were assigned to watch a television show or play a modern slot machine for 30 min, before being provided with access to alcohol. On the ad libitum procedure, gambling significantly increased the number of alcoholic drinks ordered, the volume of alcohol consumed, the participants' speed of drinking, and their intention to drink alcohol. These effects were not corroborated using the taste test procedure. Across both studies, gambling outcomes were not associated with alcohol consumption. In conjunction with prior findings, the observation that gambling can promote alcohol consumption under certain conditions highlights a possible feedback loop whereby gambling and alcohol reinforce one another. However, the divergent results between the ad libitum and taste test experiments point to boundary conditions for the effect and raise methodological considerations for future work measuring alcohol consumption in gambling environments.

Neuroscience research on gambling, including neuropsychological, neuroimaging, and psychophysiological experiments, is often regarded as aligned with the ‘brain disease model of addictions’. We assert that a bio-psycho-social framework represents the consensus view of disordered gambling, giving equal weighting to biological and psychosocial predisposing factors (and their interactions). Within this framework, we highlight three ways in which neuroscience can inform gambling research - none of which rely on one’s endorsement of biological ‘causal explanations’: i) as a toolbox of objective measures for studying gambling behaviour, ii) as a way of understanding treatment mechanisms, of both psychological and biological treatments, iii) as a way of probing the impact of gambling product features relevant to gambling policy.

© 2017, The Author(s). Altered decision making processes and excessive risk-seeking behaviours are key features of conduct disorder (CD). Previous studies have provided compelling evidence of abnormally increased preference for risky options, higher sensitivity to rewards, as well as blunted responsiveness to aversive outcomes in adolescents with CD. However, most studies published to date have focused on males only; thus, it is not known whether females with CD show similar alterations in decision making. The current study investigated potential sex differences in decision making and risk-seeking behaviours in adolescents with CD. Forty-nine adolescents with CD (23 females) and 51 control subjects (27 females), aged 11-18 years, performed a computerised task assessing decision making under risk—the Risky Choice Task. Participants made a series of decisions between two gamble options that varied in terms of their expected values and probability of gains and losses. This enabled the participants’ risk preferences to be determined. Taking the sample as a whole, adolescents with CD exhibited increased risk-seeking behaviours compared to healthy controls. However, we found a trend towards a sex-by-group interaction, suggesting that these effects may vary by sex. Follow-up analyses showed that males with CD made significantly more risky choices than their typically developing counterparts, while females with CD did not differ from typically developing females in their risk-seeking behaviours. Our results provide preliminary evidence that sex may moderate the relationship between CD and alterations in risk attitudes and reward processing, indicating that there may be sex differences in the developmental pathways and neuropsychological deficits that lead to CD. European Commission’s Seventh Framework Programme for research, technological development and demonstration (FP7/2007-2013) under Grant Agreement no. 602407 (FemNAT-CD).

Humans seek admiration to boost their social rank and engage in rivalry to protect it when fearing defeat. These social behaviors are shaped by traits and affective states, such as narcissism and depression, that influence perception of status and motivation for dominance. Narcissistic traits and depressive states are thought to prompt opposite coping mechanisms: highly narcissistic persons are compelled to protect and enhance their social rank at any cost, whereas depressed individuals may accept their inferior position to avoid further damage. Experimental data supporting these theories are however lacking. We investigated the effects of dimensionally-assessed narcissism, trait dominance and depression in a rigged video game tournament, designed to elicit rivalry (stealing points from opponents) and admiration-seeking (paying for rank). The experiment was performed by an undergraduate sample (N = 70, mean age = 21.5 years) and a clinical sample of predominantly depressed elderly (N = 85, mean age = 62.6 years). Both rivalry and admiration-seeking increased with time and were particularly enhanced in individuals high in trait dominance or narcissism. Additionally, participants engaged in more rivalry against high-ranked opponents and this tendency was accentuated by trait dominance but suppressed by depression. Our findings suggest that narcissism and social dominance manifest in increased rivalry and admiration-seeking during social contests. Depression does not generally suppress competitiveness but selectively inhibits upward-focused rivalry.

BACKGROUND AND AIMS: The Pathways Model (Blaszczynski & Nower, 2002) posits that problem gambling is a heterogeneous disorder with distinct subgroups (behaviorally conditioned gamblers, emotionally vulnerable gamblers, and antisocial-impulsivist gamblers). Impulsivity traits and gambling-related cognitions are recognized as two key psychological factors in the onset and maintenance of problem gambling. To date, these constructs have been explored separately, and their joint role in determining problem gambling subtypes has received little attention. The goal of our study was to identify subgroups of gamblers based on impulsivity traits and gambling-related cognitions, and to determine whether this approach is consistent with the Pathways model. METHODS: Gamblers from the community (N = 709) and treatment-seeking pathological gamblers (N = 122) completed questionnaires measuring gambling habits, disordered gambling symptoms, gambling-related cognitions, and impulsivity traits. RESULTS: Cluster analyses revealed that three clusters globally aligned with the pathways proposed by Blaszczynski & Nower (2002). Two other clusters emerged: (1) impulsive gamblers without cognitive-related cognitions; and (2) gamblers without impulsivity or gambling-related cognitions. Gamblers with both heightened impulsive traits and gambling-related cognitions had more severe problem gambling symptoms. CONCLUSION: We successfully identified, based on an a priori theoretical framework, different subtypes of gamblers that varied in terms of problem gambling symptoms and clinical status. The diversity of the cluster profiles supports the development of personalized prevention strategies and psychological interventions. ispartof: JOURNAL OF AFFECTIVE DISORDERS vol:260 pages:473-482 ispartof: location:Netherlands status: published

Psychological and neurobiological markers in individuals with gambling disorder (GD) could reflect transdiagnostic vulnerability to addiction or neuroadaptive consequences of long-term gambling. Using an endophenotypic approach to identify vulnerability markers, we tested the biological relatives of cases with GD. Male participants seeking treatment for GD (n = 20) were compared with a male control group (n = 18). Biological siblings of cases with GD (n = 17, unrelated to the current GD group) were compared with a separate control group (n = 19) that overlapped partially with the GD control group. Participants completed a comprehensive assessment of clinical scales, neurocognitive functioning, and fMRI of unexpected financial reward. The GD group displayed elevated levels of self-report impulsivity and delay discounting, and increased risk-taking on the Cambridge Gamble Task. We did not observe impaired motor impulsivity on the stop-signal task. Siblings of GD showed some overlapping effects; namely, elevated impulsivity (negative urgency) and increased risk-taking on the Cambridge Gamble Task. We did not observe any differences in the neural response to win outcomes, either in the GD or sibling analysis compared with their control group. Within the GD group, activity in the thalamus and caudate correlated negatively with gambling severity. Increased impulsivity and risk-taking in GD are present in biological relatives of cases with GD, suggesting these markers may represent pre-existing vulnerability to GD.

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The "winner-loser effect" refers to a phenomenon in testosterone research where the outcome of a social competition induces increases (wins) and/or decreases (losses) in testosterone levels. Here, we sought to test to what extent changes in testosterone occur in response to gambling behavior. More specifically, we hypothesized that the winner-loser effect would extend to slot machine gambling as a solitary (noncompetitive) gambling activity in players who "anthropomorphized" the slot machine, thus treating the machine as a human opponent. Male participants (n = 113) were recruited into a quasi-experimental design involving 15 min of authentic slot machine gambling, incentivized by a $10 cash bonus for participants who finished in profit. In addition to salivary measures of testosterone, salivary cortisol and self-reported anthropomorphization of the slot machine were tested as potential moderators. Contrary to predictions, winning and losing slot machine sessions did not exert significant differential effects on testosterone, and this pattern was not moderated by cortisol levels or slot machine anthropomorphization. Exploratory analyses tested relationships between subjective gambling experiences in the sessions and testosterone change. Higher positive affect and flow predicted greater testosterone declines from pre- to postgambling. The testosterone results add to a growing literature on the boundary conditions of the winner-loser effect and inform future studies on testosterone reactivity in relation to gambling and disordered gambling. The tendency to anthropomorphize slot machines is a neglected cognitive distortion in gambling that merits further study. (PsycINFO Database Record (c) 2018 APA, all rights reserved).