Search

The purpose of the paper is to study the financing models in order to drive the large amount of financial resources, already allocated for energy efficiency, to improve the quality of cities. These resources are being deployed worldwide by both public and private financial institutions. Energy efficiency is usually managed at the scale of the buildings, i.e., consumption reduction (heating, lighting, etc.). The study methodology is to review energy-efficiency finance (EEF) models, and assess them using multiple case studies. At the same time, the ownership of cities&rsquo, spaces is studied across public-private space management, as an effective methodology to bridge the gap between public and investor finance. The comparative analysis of the case studies suggests a paradigm shift in the definition of energy efficiency, not just in terms of the buildings, but instead also the local urban environment with its feedbacks on the quality of urban living. The practical implications are innovative EEF models, such as those being reviewed, which may be: (1) analytical, to assess the environment at the scale of blocks or neighbourhoods, (2) financial, to fund the specific scale, (3) relating to policy, to support and encourage. In recent years, support for urban regeneration is becoming particularly relevant, given the budget constraints of most public administrations and the conjunctural shortening of private partnerships.

Generative computation has the potential to enhance the accuracy, effectiveness, and creativity of spatial layout in design and planning. The paper proposes a methodology to separate the knowledge about objects, spatial relationships, and constraints from the generative process. The separation between the knowledge in a domain and its possible practical uses is an important achievement of semantic technologies, because it grants access to a large body of knowledge, spanning various aspects and processes across buildings and cities, which is being codified into formal ontologies. The present study has reused existing knowledge from two established ontologies. An illustrative case-project demonstrates the suitability of the methodology for a complex layout planning problem, involving a large number of decision-makers, with multiple competing objectives and criteria. The system implements multidimensional visual interactive tools to assist designers, planners, and decision-makers in exploring the layouts and the criteria, to develop their confidence in what qualifies as a good and effective solution.

Drawing on the Incubators of Public Spaces project, funded by JPI Urban Europe, this chapter considers the methods and tools used to support individuals’, groups’, organisations’ and enterprises’ self-ability to evolve towards grassroots interventions in urban regeneration processes. In particular, the chapter focuses on the assessment of the rational use and sustainable production of energy in mixed-use urban tissues, especially located in the Mediterranean region.

Zebrafish embryos homozygous for the masterblind(mbl) mutation exhibit a striking phenotype in which the eyes and telencephalon are reduced or absent and diencephalic fates expand to the front of the brain. Here we show that mbl−/−embryos carry an amino-acid change at a conserved site in the Wnt pathway scaffolding protein, Axin1. The amino-acid substitution present in the mbl allele abolishes the binding of Axin to Gsk3 and affects Tcf-dependent transcription. Therefore, Gsk3 activity may be decreased in mbl−/− embryos and in support of this possibility, overexpression of either wild-type Axin1 or Gsk3β can restore eye and telencephalic fates to mbl−/−embryos. Our data reveal a crucial role for Axin1-dependent inhibition of the Wnt pathway in the early regional subdivision of the anterior neural plate into telencephalic, diencephalic, and eye-forming territories.

The paper presents the ongoing experimentation of a Computer Supported Design Studio (CSDS). CSDS is part of our continuing effort to integrate computers and networks in the design studio. We recognise three corner stones to CSDS: memory, process and collaboration. They offer a framework for the interpretation of the pedagogical aspects of the teaching of architectural design in relation to the innovations produced by information and communication technologies. The theme of the 1998 CSDS is a railway station in Turin, Italy, to be incorporated in a reorganised rail transport system. The choice of this theme emphasises the realistic simulation aspects of the studio, where technical problems need to be interpreted from an architectural point of view.

The Future of Cities and Regions : Simulation, Scenario and Visioning, Governance and Scales is committed to presenting and discussing international best practices in planning and design according to four leading issues in urban and regional development: (1) Simulation, (2) Scenario and Visioning, (3) Government and Governance, and (4) Scale. The case-oriented discussion is a peculiarity of the book, which emerges from the title itself, The Future of Cities and Regions. The aim is to critically explain how urban planning, policy and design issues are faced by each simulation case and their inherent similarities and differences. The book reviews computer models and media, socio-political experiments and professional practices which help in communicating the future effects of different design, policy and planning strategies and schemes with a wide range of aims: from information, through consultation, towards active participation. Our intent is that the four leading issues both advance the understanding of the cases across the chapters, and advance discussion of the experiences theoretically. These issues could offer the reader a framework within which to consider the specific cases, and for interrelation of the narration of the practices from a methodological perspective, in an attempt to provide answers to the four leading issues.

The chapter gives an introduction to the development and testing of an active and dialogue methodology for a participative decision-making process for the development of Turin metropolitan city: GranTorino 2030. The active orientation requires that the metropolis involve the resources from the market and direct them towards the goals. This requires a paradigm shift in plans and policies, from legislation and financial incentives, towards the involvement of private sector and citizens, seeking equilibrium among social, private and personal utilities. GranTorino adopted a dialogue model, that is, “a complex model of interacting processes where the directives coming from the top are informed by the perceptions of problems, possible solutions, and situational constraints coming from below, and where these directives in turn structure perceptions and the search for solutions at the section level” (Mayntz 1976). GranTorino has been structured along five tiers: (1) Define the domain of public participation, (2) empower stakeholders’ knowledge, (3) generate personal foresight, (4) evaluate foresight and (5) map the knowledge. GranTorino, by listening to citizens’ preferences and expectations, has provided to a broad public the opportunity to contribute to the shaping of the metropolitan city, in order to assess what the personal foresights are, and has provided feedback through evaluation and measurement. GranTorino provides evidence that when people are actively involved, they can help to generate a heightened sense of public value.

Dickkopf-1 (Dkk1) is a secreted protein that negatively modulates the Wnt/βcatenin pathway. Lack of Dkk1 function affects head formation in frog and mice, supporting the idea that Dkk1 acts as a “head inducer” during gastrulation. We show here that lack of Dkk1 function accelerates internalization and rostral progression of the mesendoderm and that gain of function slows down both internalization and convergence extension, indicating a novel role for Dkk1 in modulating these movements. The motility phenotype found in the morphants is not observed in embryos in which the Wnt/βcatenin pathway is overactivated, and that dominant-negative Wnt proteins are not able to rescue the gastrulation movement defect induced by absence of Dkk1. These data strongly suggest that Dkk1 is acting in a βcatenin independent fashion when modulating gastrulation movements. We demonstrate that the glypican 4/6 homolog Knypek (Kny) binds to Dkk1 and that they are able to functionally interact in vivo. Moreover, Dkk1 regulation of gastrulation movements is kny dependent. Kny is a component of the Wnt/planar cell polarity (PCP) pathway. We found that indeed Dkk1 is able to activate this pathway in both Xenopus and zebrafish. Furthermore, concomitant alteration of the βcatenin and PCP activities is able to mimic the morphant accelerated cell motility phenotype. Our data therefore indicate that Dkk1 regulates gastrulation movement through interaction with LRP5/6 and Kny and coordinated modulations of Wnt/βcatenin and Wnt/PCP pathways.

Computer-Integrated Construction (CIC) is the capability of a computer system to create models of certain aspects of the design and construction processes and consequently to direct them into reality. The premise of CIC is that the clear-cut separation between the competencies, know-how and responsibilities has now been turned upside down by the introduction of information technology in the design and construction processes. The designers can now model the physical, technological, and organisational aspects of a building or infrastructure in a seamless way. And they can do so rather creatively. The model of the physical system provides the designer an intuitive understanding and appreciation of static and dynamic interaction between the building and its environment early during design. The model of the technological system opens the capability to precisely model the building parts "as-constructed" by means of quantitative and qualitative-visual evaluation before any manufacturing process really takes place. The paper briefly introduces CIC in four construction technologies, respectively concrete, stone, wood and steel. The model of the construction organization is the process of configuring an organisational structure to accomplish a given high-level task while attempting to satisfy stated performance objectives. An organization model represents people supported by information-processing and communication tools. The CIC implementation and on-field experimentation is considered in a case project.

Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tlc, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tlc. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.

The paper presents the implementation of a system of Shared Virtual Reality (SVR) in Internet applied to a large-scale project. The applications of SVR to architectural and urban design are presented in the context of a real project, the new railway junction of Porta Susa and the surrounding urban area in the city centre of Turin, Italy. SVR differs from Virtual Reality (VR) in that the experience of virtual spaces is no longer individual, but rather shared across the Internet with other users simultaneously connected. SVR offers an effective approach to Construction Data Model and Computer Supported Collaborative Work, because it integrates both the communicative tools to improve collaboration and the distributed environment to process information across the networks.

The paper outlines a research project to develop a dynamic simulation of suburbanization processes. The approach to simulating suburban form relies on modelling different interacting processes on various scales. Two layered models are implemented, the Socio-Economic and Zoning model and the Suburban Form model, respectively by means of cellular automata and genetic programming. The Socio-Economic and Zoning model simulates exogenous factors and endogenous processes of large-scale suburban dynamics. The model approximates the area by means of a rectangular grid to the scale of hundred meters. The Suburban Form model uses a smaller grid, to the scale of meters, and is three-dimensional. The resulting dynamic, 3D, fine-scale model will create scenarios of suburban growth, allowing evaluation of their consequences on built environment and landscape.

The developing zebrafish embryo has been the subject of many studies of regional patterning, stereotypical cell movements and changes in cell shape. To better study the morphological features of cells during gastrulation, we generated mosaic embryos expressing membrane attached Dendra2 to highlight cellular boundaries. We find that intercellular bridges join a significant fraction of epiblast cells in the zebrafish embryo, reaching several cell diameters in length and spanning across different regions of the developing embryos. These intercellular bridges are distinct from the cellular protrusions previously reported as extending from hypoblast cells (1-2 cellular diameters in length) or epiblast cells (which were shorter). Most of the intercellular bridges were formed at pre-gastrula stages by the daughters of a dividing cell maintaining a membrane tether as they move apart after mitosis. These intercellular bridges persist during gastrulation and can mediate the transfer of proteins between distant cells. These findings reveal a surprising feature of the cellular landscape in zebrafish embryos and open new possibilities for cell-cell communication during gastrulation, with implications for modeling, cellular mechanics, and morphogenetic signaling.

The development of multicellular organisms is dependent on the tight coordination between tissue growth and morphogenesis. The stereotypical orientation of cell divisions has been proposed to be a fundamental mechanism by which proliferating and growing tissues take shape. However, the actual contribution of stereotypical division orientation (SDO) to tissue morphogenesis is unclear. In zebrafish, cell divisions with stereotypical orientation have been implicated in both body-axis elongation and neural rod formation [[1] and [2]], although there is little direct evidence for a critical function of SDO in either of these processes. Here we show that SDO is required for formation of the neural rod midline during neurulation but dispensable for elongation of the body axis during gastrulation. Our data indicate that SDO during both gastrulation and neurulation is dependent on the noncanonical Wnt receptor Frizzled 7 (Fz7) and that interfering with cell division orientation leads to severe defects in neural rod midline formation but not body-axis elongation. These findings suggest a novel function for Fz7-controlled cell division orientation in neural rod midline formation during neurulation.

Incubators of Public Spaces is a funded JPI Urban Europe project aiming to support the self-organization of places by enhancing the factors that motivate, encourage, and enable the urban actors to reach common understandings in order to coordinate their actions by reasoned argument, consensus, and cooperation rather than strategic thinking only. By catalyzing citizens’ willingness to ‘do their bit’ for improving spaces, it provides the means to grow and care for places. The paper is organized into three main sections. The first section offers a theoretical underpinning on the roots of self-organization and co-creation in urban interventions. After a brief introduction about the project’s aims, the second section deals with incubators’ co-creative process and system. It describes the running of the scenario workshops and provides an overview of the web platform and its inherent features. The third section presents the results of the application of the incubators method in the regeneration of an Italian neighborhood. It provides some general information about the area, and foresees a set of interventions for both built and open spaces. Conclusions offer early remarks concerning the ongoing experimentation in Incubators.

Progettare per costruire con gli strumenti digitali richiede competenze specifiche nei processi di fabbricazione e nei linguaggi in uso dai sistemi informatici. Il volume propone anche una guida pratica ai nuovi modi e tecniche di gestione e controllo della produzione per l'edilizia. Sistematizzare le nuove competenze per la progettazione ha l'intento di prospettare opportunità ad architetti e ingegneri. Tramite la documentazione e l'analisi di realizzazioni significative il volume approfondisce le potenzialità tecniche e figurative del digitale. I progetti considerati sono l'esito di sperimentazioni che hanno saputo dare forma e significato alla ricerca tecnologica. Dimostrano che gli strumenti digitali non sono prerogativa esclusiva di grandi studi internazionali, possono essere adottati anche da team tra studi medio-piccoli. Studi che hanno saputo finalizzare una ricerca consapevole, capace di coniugare le sperimentazioni progettuali con le possibilità offerte dalla costruzione digitale dell'architettura