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4. Abstract 16061: Correlation Between Obesity and Ventricular Tachycardia in Individuals With HFrEF: Analysis From the DERIVATE Cohort

Author

Mosley, Jackson L, Voruganti, Dinesh, Sadaf, Murrium I, Mansour, Munthir, Spraggins, Robert, Abouelenein, Saly, Abete, Raffaele, Aquaro, Giovanni, Baggiano, Andrea, Barison, Andrea, Bogaert, Jan, Camastra, Giovanni, Carigi, Samuela, Carrabba, Nazario, Casavecchia, Grazia, Censi, Stefano, Cicala, Gloria, De Cecco, Carlo, De Lazzari, Manuel, Di Giovine, Gabriella, Calo, Leonardo, Dobrovie, Monica, Focardi, Marta, Fusini, Laura, Gaibazzi, Nicola, Gismondi, Annalaura, Gravina, Matteo, Guglielmo, Marco, Lanzillo, chiara, lombardi, massimo, Lorenzoni, Valentina, Lozano Torres, Jordi, Margonato, Davide, Martini, Chiara, Marzo, Francesca, Masci, Pier-Giorgio, Masi, Ambra, Moro, Claudio, Muscogiuri, Giuseppe, Mushtaq, Saima, Nese, Alberto, Palumbo, Alessandro, Pavon, Anna Giulia, Pedrotti, Patrizia, Perazzolo Marra, Martina, Praadella, Silvia, Presicci, Cristina, Pontone, Gianluca, and AlʼAref, Subhi J

Published
2023
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5. Abstract 14398: Predictors of Major Adverse Cardiac Events in Individuals With Left Bundle Branch Block and Cardiac Resynchronization Therapy: Analysis From the Derivate Registry

Author

Mueller, Joshua, Jensen, Hanna, Robinson, Samantha, Abete, Raffaele, Aquaro, Giovanni, Baggiano, Andrea, Barison, Andrea, Bogaert, Jan, Camastra, Giovanni, Carigi, Samuela, Carrabba, Nazario, Casavecchia, Grazia, Censi, Stefano, Cicala, Gloria, De Cecco, Carlo, De Lazzari, Manuel, Di Giovine, Gabriella, Calo, Leonardo, Dobrovie, Monica, Focardi, Marta, Fusini, Laura, Gaibazzi, Nicola, Gismondi, Annalaura, Gravina, Matteo, Guglielmo, Marco, Lanzillo, chiara, lombardi, massimo, Lorenzoni, Valentina, Lozano Torres, Jordi, Margonato, Davide, Martini, Chiara, Marzo, Francesca, Masci, Pier-Giorgio, Masi, Ambra, Moro, Claudio, Muscogiuri, Giuseppe, Mushtaq, Saima, Nese, Alberto, Palumbo, Alessandro, Pavon, Anna Giulia, Pedrotti, Patrizia, Perazzolo Marra, Martina, Pradella, Silvia, Presicci, Cristina, Rabbat, Mark, Raineri, Claudi, Rodriguez-Palomares, Jose, Pontone, Gianluca, and AlʼAref, Subhi J

Published
2023
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6. Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy: The DERIVATE–ICM International Registry

Author

Pontone, Gianluca, Guaricci, Andrea Igoren, Fusini, Laura, Baggiano, Andrea, Guglielmo, Marco, Muscogiuri, Giuseppe, Volpe, Alessandra, Abete, Raffaele, Aquaro, Giovanni, Barison, Andrea, Bogaert, Jan, Camastra, Giovanni, Carigi, Samuela, Carrabba, Nazario, Casavecchia, Grazia, Censi, Stefano, Cicala, Gloria, De Cecco, Carlo N., De Lazzari, Manuel, Di Giovine, Gabriella, Di Roma, Mauro, Dobrovie, Monica, Focardi, Marta, Gaibazzi, Nicola, Gismondi, Annalaura, Gravina, Matteo, Lanzillo, Chiara, Lombardi, Massimo, Lorenzoni, Valentina, Lozano-Torres, Jordi, Martini, Chiara, Marzo, Francesca, Masi, Ambra, Memeo, Riccardo, Moro, Claudio, Nese, Alberto, Palumbo, Alessandro, Pavon, Anna Giulia, Pedrotti, Patrizia, Marra, Martina Perazzolo, Pica, Silvia, Pradella, Silvia, Presicci, Cristina, Rabbat, Mark G., Raineri, Claudia, Rodriguez-Palomares, José F., Sbarbati, Stefano, Schoepf, U. Joseph, Squeri, Angelo, Sverzellati, Nicola, Symons, Rolf, Tat, Emily, Timpani, Mauro, Todiere, Giancarlo, Valentini, Adele, Varga-Szemes, Akos, Masci, Pier-Giorgio, and Schwitter, Juerg

Published
2023
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7. Effects of Enzyme Replacement Therapy on Cardiac MRI Findings in Fabry Disease: A Systematic Review and Meta-Analysis

Author

Figliozzi, Stefano, primary, Kollia, Eleni, additional, Simistiras, Alexandros, additional, Camporeale, Antonia, additional, Stankowski, Kamil, additional, Masci, Pier Giorgio, additional, Mavraganis, George, additional, Lombardi, Massimo, additional, Condorelli, Gianluigi, additional, Francone, Marco, additional, Pieroni, Maurizio, additional, and Georgiopoulos, Georgios, additional

Published
2024
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8. Cost-Minimization Analysis for Cardiac Revascularization in 12 Health Care Systems Based on the EuroCMR/SPINS Registries

Author

Moschetti, Karine, Kwong, Raymond Y., Petersen, Steffen E., Lombardi, Massimo, Garot, Jerome, Atar, Dan, Rademakers, Frank E., Sierra-Galan, Lilia M., Mavrogeni, Sophie, Li, Kuncheng, Fernandes, Juliano Lara, Schneider, Steffen, Pinget, Christophe, Ge, Yin, Antiochos, Panagiotis, Deluigi, Christina, Bruder, Oliver, Mahrholdt, Heiko, and Schwitter, Juerg

Published
2022
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10. When Paying Attention Pays Back: Missense Mutation c.1006G>A p. (Val336Ile) in PRKAG2 Gene Causing Left Ventricular Hypertrophy and Conduction Abnormalities in a Caucasian Patient: Case Report and Literature Review.

Author

Micaglio, Emanuele, Tondi, Lara, Benedetti, Sara, Schiavo, Maria Alessandra, Camporeale, Antonia, Disabato, Giandomenico, Attanasio, Andrea, Guida, Gianluigi, Carrafiello, Gianpaolo, Piepoli, Massimo, Spagnolo, Pietro, Pappone, Carlo, and Lombardi, Massimo

Subjects
CARDIAC magnetic resonance imaging, LEFT ventricular hypertrophy, HYPERTROPHIC cardiomyopathy, LITERATURE reviews, GENETIC disorders
Abstract

PRKAG2 cardiomyopathy is a rare genetic disorder that manifests early in life with an autosomal dominant inheritance pattern. It harbors left ventricular hypertrophy (LVH), ventricular pre-excitation and progressively worsening conduction system defects. Its estimated prevalence among patients with LVH ranges from 0.23 to about 1%, but it is likely an underdiagnosed condition. We report the association of the PRKAG2 missense variant c.1006G>A p. (Val336Ile) with LVH, conduction abnormalities (short PR interval and incomplete right bundle branch bock) and early-onset arterial hypertension (AH) in a 44-year-old Caucasian patient. While cardiac magnetic resonance (CMR) showed a mild hypertrophic phenotype with maximal wall thickness of 17 mm in absence of tissue alterations, the electric phenotype was relevant including brady–tachy syndrome and recurrent syncope. The same variant has been detected in the patient's sister and daughter, with LVH + early-onset AH and electrocardiographic (ECG) alterations + lipothymic episodes, respectively. Paying close attention to the coexistence of LVH and ECG alterations in the proband has been helpful in directing genetic tests to exclude primary cardiomyopathy. Hence, identifying the genetic basis in the patient allowed for familial screening as well as a proper follow-up and therapeutic management of the affected members. A review of the PRKAG2 cardiomyopathy literature is provided alongside the case report. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Abstract 10990: The Prognostic Significance of Right Ventricular Dilation Assessed by Cardiac Magnetic Resonance Imaging in Heart Failure With Reduced Ejection Fraction

Author

Malkawi, Abdallah, Altibi, Ahmed, Mansour, Munthir, Schwitter, Juerg, Guaricci, Andrea, Masci, Pier-Giorgio, De Cecco, Carlo, Carrabba, Nazario, Varga-Szemes, Akos, Masi, Ambra, Baggiano, Andrea, Barison, Andrea, lanzillo, chiara, Martini, Chiara, moro, claudia, Andreini, Daniele, Conte, Edoardo, Rabbat, Mark, Focardi, Marta, Perazzolo Marra, Martina, Lombardi, Massimo, Dobrovie, Monica, Gaibazzi, Nicola, PEDROTTI, PATRIZIA, Schoepf, Joseph, Mushtaq, Saima, Censi, Stefano, Tat, Emily, Bogaert, Jan, Lozano Torres, Jordi, Sverzellati, Nicola, Marco, Guglielmo, Gismondi, Annalaura, Gravina, Matteo, Presicci, Cristina, De Lazzari, Manuel, Palumbo, Alessandro, Valentini, Adele, Di Giovine, Gabriella, Fusini, Laura, Margonato, Davide, Timpani, Mauro, Nese, Alberto, Pepi, Mauro, Cicala, Gloria, Muscogiuri, Giuseppe, Lorenzoni, Valentina, Pontone, Gianluca, and AlʼAref, Subhi J

Published
2022
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14. Arrhythmic Mitral Valve Prolapse Phenotype: An Unsupervised Machine-learning Analysis Using a Multi-center Registry

Author

Figliozzi, Stefano, primary, Akyea, Ralph Kwame, additional, Lopes, Pedro M, additional, Moura-Ferreira, Sara, additional, Tondi, Lara, additional, Mushtaq, Saima, additional, Censi, Stefano, additional, Pavon, Anna Giulia, additional, Bassi, Ilaria, additional, Galian, Laura, additional, Teske, Arco J, additional, Filomena, Domenico, additional, Torlasco, Camilla, additional, Monney, Pierre, additional, Maestrini, Viviana, additional, Pedrotti, Patrizia, additional, Vandenberk, Bert, additional, Squeri, Angelo, additional, Lombardi, Massimo, additional, Schwitter, Juerg, additional, Aquaro, Giovanni Donato, additional, Chiribiri, Amedeo, additional, Palomares, José F Rodríguez, additional, Monti, Lorenzo, additional, Yilmaz, Ali, additional, Andreini, Daniele, additional, Florian, Anca, additional, Francone, Marco, additional, Pontone, Gianluca, additional, Abecassis, Joao, additional, Leiner, Tim, additional, Badano, Luigi P, additional, Bogaert, Jan, additional, Georgiopoulos, Georgios, additional, and Masci, Pier Giorgio, additional

Published
2024
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15. Left Ventricle Diastolic Vortex Ring Characterization in Ischemic Cardiomyopathy: Insight into Atrio-ventricular Interplay

Author

Riva, Alessandra, primary, Saitta, Simone, additional, Sturla, Francesco, additional, Disabato, Giandomenico, additional, Tondi, Lara, additional, Camporeale, Antonia, additional, Giese, Daniel, additional, Castelvecchio, Serenella, additional, Menicanti, Lorenzo, additional, Redaelli, Alberto, additional, Lombardi, Massimo, additional, and Votta, Emiliano, additional

Published
2024
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16. Digital Ulcers and Ventricular Arrhythmias as Red Flags to Predict Replacement Myocardial Fibrosis in Systemic Sclerosis

Author

Gargani, Luna, primary, Bruni, Cosimo, additional, Todiere, Giancarlo, additional, Pugliese, Nicola Riccardo, additional, Bandini, Giulia, additional, Bellando-Randone, Silvia, additional, Guiducci, Serena, additional, D’Angelo, Gennaro, additional, Campochiaro, Corrado, additional, De Luca, Giacomo, additional, Stagnaro, Chiara, additional, Lombardi, Massimo, additional, Dagna, Lorenzo, additional, Pepe, Alessia, additional, Allanore, Yannick, additional, Moggi-Pignone, Alberto, additional, and Matucci-Cerinic, Marco, additional

Published
2023
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18. Digital Ulcers and Ventricular Arrhythmias as Red Flags to Predict Replacement Myocardial Fibrosis in Systemic Sclerosis.

Author

Gargani, Luna, Bruni, Cosimo, Todiere, Giancarlo, Pugliese, Nicola Riccardo, Bandini, Giulia, Bellando-Randone, Silvia, Guiducci, Serena, D'Angelo, Gennaro, Campochiaro, Corrado, De Luca, Giacomo, Stagnaro, Chiara, Lombardi, Massimo, Dagna, Lorenzo, Pepe, Alessia, Allanore, Yannick, Moggi-Pignone, Alberto, and Matucci-Cerinic, Marco

Subjects
SYSTEMIC scleroderma, VENTRICULAR arrhythmia, PATIENT selection, FIBROSIS, ULCERS, CAPILLAROSCOPY, PROGNOSIS, LIVER histology
Abstract

Background: Cardiac involvement in systemic sclerosis (SSc) affects the prognosis of the disease. Echocardiography is the first line imaging tool to detect cardiac involvement, but it is not able to routinely detect myocardial fibrosis. Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is the gold standard for replacement myocardial fibrosis assessment, but its availability is currently limited. Aim: We aimed to assess the clinical and instrumental parameters that would be useful for predicting the presence of LGE-CMR, to achieve a better selection of patients with SSc that could benefit from third-level CMR imaging. Methods: 344 SSc patients underwent a comprehensive echocardiogram and LGE-CMR on the same day; for 189 patients, a 24 h ECG Holter monitoring was available. Results: CMR showed non-junctional replacement myocardial fibrosis via LGE in 25.1% patients. A history of digital ulcers (OR 2.188; 95% C.I. 1.069–4.481) and ventricular arrhythmias at ECG Holter monitoring (OR 3.086; 95% C.I. 1.191–7.998) were independent predictors of replacement myocardial fibrosis. Conclusions: CMR can detect patterns of clinical and subclinical cardiac involvement, which are frequent in SSc. A history of digital ulcers and evidence of ventricular arrhythmias at ECG Holter monitoring are red flags for the presence of replacement myocardial fibrosis in CMR. The association between digital ulcers and myocardial fibrosis suggests that a similar pathological substrate of abnormal vascular function may underlie peripheral vascular and cardiac complications. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Kiosk 9R-TA-07 - Arrhythmic Mitral Valve Prolapse Phenotype: An Unsupervised Machine-learning Analysis Using a Multi-center Registry

Author

Figliozzi, Stefano, Akyea, Ralph Kwame, Lopes, Pedro M, Moura-Ferreira, Sara, Tondi, Lara, Mushtaq, Saima, Censi, Stefano, Pavon, Anna Giulia, Bassi, Ilaria, Galian, Laura, Teske, Arco J, Filomena, Domenico, Torlasco, Camilla, Monney, Pierre, Maestrini, Viviana, Pedrotti, Patrizia, Vandenberk, Bert, Squeri, Angelo, Lombardi, Massimo, Schwitter, Juerg, Aquaro, Giovanni Donato, Chiribiri, Amedeo, Palomares, José F Rodríguez, Monti, Lorenzo, Yilmaz, Ali, Andreini, Daniele, Florian, Anca, Francone, Marco, Pontone, Gianluca, Abecassis, Joao, Leiner, Tim, Badano, Luigi P, Bogaert, Jan, Georgiopoulos, Georgios, and Masci, Pier Giorgio

Published
2024
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20. Kiosk 2R-FC-02 - Unveiling the Distinctive Phenotypes of Arrhythmic Mitral Valve Prolapse by High-density Myocardial Strain Imaging and Late-gadolinium-enhancement Microstructure Analysis

Author

Maio, Silvana Di, Zaidi, Hassan, Vandenberk, Bert, Censi, Stefano, Figliozzi, Stefano, Tondi, Lara, Lombardi, Massimo, Aquaro, Giovanni Donato, Andreini, Daniele, Bauer, Klemens B, Di Maio, Silvana, Squeri, Angelo, Torlasco, Camilla, Galian, Laura, Mushtaq, Saima, Rodríguez Palomares, José F, Marchenko, Oksana, Pontone, Gianluca, Monti, Lorenzo, Giulia Pavon, Anna, Teske, Arco J, Florian, Anca, Agricola, Eustachio, Francone, Marco, Badano, Luigi P, Yilmaz, Ali, Schwitter, Juerg, Georgiopoulos, Georgios, Lamata, Pablo, Grapsa, Julia, Leiner, Tim, Bogaert, Jan, Bishop, Martin, and Giorgio Masci, Pier

Published
2024
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24. AI Cardiac MRI Scar Analysis Aids Prediction of Major Arrhythmic Events in the Multicenter DERIVATE Registry

Author

Ghanbari, Fahime, primary, Joyce, Thomas, additional, Lorenzoni, Valentina, additional, Guaricci, Andrea I., additional, Pavon, Anna-Giulia, additional, Fusini, Laura, additional, Andreini, Daniele, additional, Rabbat, Mark G., additional, Aquaro, Giovanni Donato, additional, Abete, Raffaele, additional, Bogaert, Jan, additional, Camastra, Giovanni, additional, Carigi, Samuela, additional, Carrabba, Nazario, additional, Casavecchia, Grazia, additional, Censi, Stefano, additional, Cicala, Gloria, additional, De Cecco, Carlo N., additional, De Lazzari, Manuel, additional, Di Giovine, Gabriella, additional, Di Roma, Mauro, additional, Focardi, Marta, additional, Gaibazzi, Nicola, additional, Gismondi, Annalaura, additional, Gravina, Matteo, additional, Lanzillo, Chiara, additional, Lombardi, Massimo, additional, Lozano-Torres, Jordi, additional, Masi, Ambra, additional, Moro, Claudio, additional, Muscogiuri, Giuseppe, additional, Nese, Alberto, additional, Pradella, Silvia, additional, Sbarbati, Stefano, additional, Schoepf, U. Joseph, additional, Valentini, Adele, additional, Crelier, Gérard, additional, Masci, Pier Giorgio, additional, Pontone, Gianluca, additional, Kozerke, Sebastian, additional, and Schwitter, Juerg, additional

Published
2023
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25. Myocardial Fibrosis at Cardiac MRI Helps Predict Adverse Clinical Outcome in Patients with Mitral Valve Prolapse

Author

Figliozzi, S, Georgiopoulos, G, Lopes, P, Bauer, K, Moura-Ferreira, S, Tondi, L, Mushtaq, S, Censi, S, Pavon, A, Bassi, I, Servato, M, Teske, A, Biondi, F, Filomena, D, Pica, S, Torlasco, C, Muraru, D, Monney, P, Quattrocchi, G, Maestrini, V, Agati, L, Monti, L, Pedrotti, P, Vandenberk, B, Squeri, A, Lombardi, M, Ferreira, A, Schwitter, J, Aquaro, G, Chiribiri, A, Rodríguez Palomares, J, Yilmaz, A, Andreini, D, Florian, A, Leiner, T, Abecasis, J, Badano, L, Bogaert, J, Masci, P, Figliozzi, Stefano, Georgiopoulos, Georgios, Lopes, Pedro M, Bauer, Klemens B, Moura-Ferreira, Sara, Tondi, Lara, Mushtaq, Saima, Censi, Stefano, Pavon, Anna Giulia, Bassi, Ilaria, Servato, Maria Luz, Teske, Arco J, Biondi, Federico, Filomena, Domenico, Pica, Silvia, Torlasco, Camilla, Muraru, Denisa, Monney, Pierre, Quattrocchi, Giuseppina, Maestrini, Viviana, Agati, Luciano, Monti, Lorenzo, Pedrotti, Patrizia, Vandenberk, Bert, Squeri, Angelo, Lombardi, Massimo, Ferreira, António M, Schwitter, Juerg, Aquaro, Giovanni Donato, Chiribiri, Amedeo, Rodríguez Palomares, José F, Yilmaz, Ali, Andreini, Daniele, Florian, Anca, Leiner, Tim, Abecasis, João, Badano, Luigi, Bogaert, Jan, Masci, Pier-Giorgio, Figliozzi, S, Georgiopoulos, G, Lopes, P, Bauer, K, Moura-Ferreira, S, Tondi, L, Mushtaq, S, Censi, S, Pavon, A, Bassi, I, Servato, M, Teske, A, Biondi, F, Filomena, D, Pica, S, Torlasco, C, Muraru, D, Monney, P, Quattrocchi, G, Maestrini, V, Agati, L, Monti, L, Pedrotti, P, Vandenberk, B, Squeri, A, Lombardi, M, Ferreira, A, Schwitter, J, Aquaro, G, Chiribiri, A, Rodríguez Palomares, J, Yilmaz, A, Andreini, D, Florian, A, Leiner, T, Abecasis, J, Badano, L, Bogaert, J, Masci, P, Figliozzi, Stefano, Georgiopoulos, Georgios, Lopes, Pedro M, Bauer, Klemens B, Moura-Ferreira, Sara, Tondi, Lara, Mushtaq, Saima, Censi, Stefano, Pavon, Anna Giulia, Bassi, Ilaria, Servato, Maria Luz, Teske, Arco J, Biondi, Federico, Filomena, Domenico, Pica, Silvia, Torlasco, Camilla, Muraru, Denisa, Monney, Pierre, Quattrocchi, Giuseppina, Maestrini, Viviana, Agati, Luciano, Monti, Lorenzo, Pedrotti, Patrizia, Vandenberk, Bert, Squeri, Angelo, Lombardi, Massimo, Ferreira, António M, Schwitter, Juerg, Aquaro, Giovanni Donato, Chiribiri, Amedeo, Rodríguez Palomares, José F, Yilmaz, Ali, Andreini, Daniele, Florian, Anca, Leiner, Tim, Abecasis, João, Badano, Luigi, Bogaert, Jan, and Masci, Pier-Giorgio

Abstract

Background: Patients with mitral valve prolapse (MVP) may develop adverse outcomes even in the absence of mitral regurgitation or left ventricular (LV) dysfunction. Purpose: To investigate the prognostic value of mitral annulus disjunction (MAD) and myocardial fibrosis at late gadolinium enhancement (LGE) cardiac MRI in patients with MVP without moderate-to-severe mitral regurgitation or LV dysfunction. Materials and Methods: In this longitudinal retrospective study, 118 144 cardiac MRI studies were evaluated between October 2007 and June 2020 at 15 European tertiary medical centers. Follow-up was from the date of cardiac MRI examination to June 2020; the minimum and maximum follow-up intervals were 6 months and 156 months, respectively. Patients were excluded if at least one of the following conditions was present: cardiomyopathy, LV ejection fraction less than 40%, ischemic heart disease, congenital heart disease, inflammatory heart disease, moderate or worse mitral regurgitation, participation in competitive sport, or electrocardiogram suggestive of channelopathies. In the remainder, cardiac MRI studies were reanalyzed, and patients were included if they were aged 18 years or older, MVP was diagnosed at cardiac MRI, and clinical information and electrocardiogram monitoring were available within 3 months from cardiac MRI examination. The end point was a composite of adverse outcomes: sustained ventricular tachycardia (VT), sudden cardiac death (SCD), or unexplained syncope. Multivariable Cox regression analysis was performed. Results: A total of 474 patients (mean age, 47 years ± 16 [SD]; 244 women) were included. Over a median follow-up of 3.3 years, 18 patients (4%) reached the study end point. LGE presence (hazard ratio, 4.2 [95% CI: 1.5, 11.9]; P = .006) and extent (hazard ratio, 1.2 per 1% increase [95% CI: 1.1, 1.4]; P = .006), but not MAD presence (P = .89), were associated with clinical outcome. LGE presence had incremental prognostic value over MVP severi

Published
2023

26. Myocardial Fibrosis at Cardiac MRI Helps Predict Adverse Clinical Outcome in Patients with Mitral Valve Prolapse

Author

Team Medisch, Circulatory Health, MS Radiologie, Figliozzi, Stefano, Georgiopoulos, Georgios, Lopes, Pedro M, Bauer, Klemens B, Moura-Ferreira, Sara, Tondi, Lara, Mushtaq, Saima, Censi, Stefano, Pavon, Anna Giulia, Bassi, Ilaria, Servato, Maria Luz, Teske, Arco J, Biondi, Federico, Filomena, Domenico, Pica, Silvia, Torlasco, Camilla, Muraru, Denisa, Monney, Pierre, Quattrocchi, Giuseppina, Maestrini, Viviana, Agati, Luciano, Monti, Lorenzo, Pedrotti, Patrizia, Vandenberk, Bert, Squeri, Angelo, Lombardi, Massimo, Ferreira, António M, Schwitter, Juerg, Aquaro, Giovanni Donato, Chiribiri, Amedeo, Rodríguez Palomares, José F, Yilmaz, Ali, Andreini, Daniele, Florian, Anca, Leiner, Tim, Abecasis, João, Badano, Luigi Paolo, Bogaert, Jan, Masci, Pier-Giorgio, Team Medisch, Circulatory Health, MS Radiologie, Figliozzi, Stefano, Georgiopoulos, Georgios, Lopes, Pedro M, Bauer, Klemens B, Moura-Ferreira, Sara, Tondi, Lara, Mushtaq, Saima, Censi, Stefano, Pavon, Anna Giulia, Bassi, Ilaria, Servato, Maria Luz, Teske, Arco J, Biondi, Federico, Filomena, Domenico, Pica, Silvia, Torlasco, Camilla, Muraru, Denisa, Monney, Pierre, Quattrocchi, Giuseppina, Maestrini, Viviana, Agati, Luciano, Monti, Lorenzo, Pedrotti, Patrizia, Vandenberk, Bert, Squeri, Angelo, Lombardi, Massimo, Ferreira, António M, Schwitter, Juerg, Aquaro, Giovanni Donato, Chiribiri, Amedeo, Rodríguez Palomares, José F, Yilmaz, Ali, Andreini, Daniele, Florian, Anca, Leiner, Tim, Abecasis, João, Badano, Luigi Paolo, Bogaert, Jan, and Masci, Pier-Giorgio

Published
2023

28. Cardiovascular Magnetic Resonance in Patients with Cardiac Electronic Devices: Evidence from a Multicenter Study.

Author

Barison, Andrea, Ricci, Fabrizio, Pavon, Anna Giulia, Muscogiuri, Giuseppe, Bisaccia, Giandomenico, Camastra, Giovanni, De Lazzari, Manuel, Lanzillo, Chiara, Raguso, Mario, Monti, Lorenzo, Vargiu, Sara, Pedrotti, Patrizia, Piacenti, Marcello, Todiere, Giancarlo, Pontone, Gianluca, Indolfi, Ciro, Dellegrottaglie, Santo, Lombardi, Massimo, Schwitter, Juerg, and Aquaro, Giovanni Donato

Subjects
CARDIAC magnetic resonance imaging, ELECTRONIC equipment, ELECTRONIC evidence, CARDIAC pacemakers, MEDICAL artifacts, MAGNETIC resonance, ARTIFICIAL implants
Abstract

Background: Most recent cardiac implantable electronic devices (CIEDs) can safely undergo a cardiovascular magnetic resonance (CMR) scan under certain conditions, but metal artifacts may degrade image quality. The aim of this study was to assess the overall diagnostic yield of CMR and the extent of metal artifacts in a multicenter, multivendor study on CIED patients referred for CMR. Methods: We analyzed 309 CMR scans from 292 patients (age 57 ± 16 years, 219 male) with an MR-conditional pacemaker (n = 122), defibrillator (n = 149), or loop recorder (n = 38); CMR scans were performed in 10 centers from 2012 to 2020; MR-unsafe implants were excluded. Clinical and device parameters were recorded before and after the CMR scan. A visual analysis of metal artifacts was performed for each sequence on a segmental basis, based on a 5-point artifact score. Results: The vast majority of CMR scans (n = 255, 83%) were completely performed, while only 32 (10%) were interrupted soon after the first sequences and 22 (7%) were only partly acquired; CMR quality was non-diagnostic in 34 (11%) scans, poor (<1/3 sequences were diagnostic) in 25 (8%), or acceptable (1/3 to 2/3 sequences were diagnostic) in 40 (13%), while most scans (n = 201, 68%) were of overall good quality. No adverse event or device malfunctioning occurred, and only nonsignificant changes in device parameters were recorded. The most affected sequences were SSFP (median score 0.32 [interquartile range 0.07–0.91]), followed by GRE (0.18 [0.02–0.59]) and LGE (0.14 [0.02–0.55]). ICDs induced more artifacts (median score in SSFP images 0.87 [0.50–1.46]) than PMs (0.11 [0.03–0.28]) or ILRs (0.11 [0.00–0.56]). Moreover, most artifacts were located in the anterior, anteroseptal, anterolateral, and apical segments of the LV and in the outflow tract of the RV. Conclusions: CMR is a versatile imaging technique, with a high safety profile and overall good image quality even in patients with MR-conditional CIEDs. Several strategies are now available to optimize image quality, substantially enhancing overall diagnostic yield. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Effect of Migalastat on cArdiac Involvement in FabRry Disease: MAIORA study

Author

Camporeale, Antonia, primary, Bandera, Francesco, additional, Pieroni, Maurizio, additional, Pieruzzi, Federico, additional, Spada, Marco, additional, Bersano, Anna, additional, Econimo, Laura, additional, Lanzillo, Chiara, additional, Rubino, Marta, additional, Mignani, Renzo, additional, Motta, Irene, additional, Olivotto, Iacopo, additional, Tanini, Ilaria, additional, Valaperta, Rea, additional, Chow, Kelvin, additional, Baroni, Irene, additional, Boveri, Sara, additional, Graziani, Francesca, additional, Pica, Silvia, additional, Tondi, Lara, additional, Guazzi, Marco, additional, and Lombardi, Massimo, additional

Published
2023
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30. Myocardial Fibrosis at Cardiac MRI Helps Predict Adverse Clinical Outcome in Patients with Mitral Valve Prolapse

Author

Figliozzi, Stefano, primary, Georgiopoulos, Georgios, additional, Lopes, Pedro M., additional, Bauer, Klemens B., additional, Moura-Ferreira, Sara, additional, Tondi, Lara, additional, Mushtaq, Saima, additional, Censi, Stefano, additional, Pavon, Anna Giulia, additional, Bassi, Ilaria, additional, Servato, Maria Luz, additional, Teske, Arco J., additional, Biondi, Federico, additional, Filomena, Domenico, additional, Pica, Silvia, additional, Torlasco, Camilla, additional, Muraru, Denisa, additional, Monney, Pierre, additional, Quattrocchi, Giuseppina, additional, Maestrini, Viviana, additional, Agati, Luciano, additional, Monti, Lorenzo, additional, Pedrotti, Patrizia, additional, Vandenberk, Bert, additional, Squeri, Angelo, additional, Lombardi, Massimo, additional, Ferreira, António M., additional, Schwitter, Juerg, additional, Aquaro, Giovanni Donato, additional, Chiribiri, Amedeo, additional, Rodríguez Palomares, José F., additional, Yilmaz, Ali, additional, Andreini, Daniele, additional, Florian, Anca, additional, Leiner, Tim, additional, Abecasis, João, additional, Badano, Luigi Paolo, additional, Bogaert, Jan, additional, and Masci, Pier-Giorgio, additional

Published
2023
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33. Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy

Author

Al’Aref, Subhi J, primary, Altibi, Ahmed M, additional, Malkawi, Abdallah, additional, Mansour, Munthir, additional, Baskaran, Lohendran, additional, Masri, Ahmad, additional, Rahmouni, Hind, additional, Abete, Raffaele, additional, Andreini, Daniele, additional, Aquaro, Giovanni, additional, Barison, Andrea, additional, Bogaert, Jan, additional, Camastra, Giovanni, additional, Carigi, Samuela, additional, Carrabba, Nazario, additional, Casavecchia, Grazia, additional, Censi, Stefano, additional, Cicala, Gloria, additional, Conte, Edoardo, additional, De Cecco, Carlo N, additional, De Lazzari, Manuel, additional, Di Giovine, Gabriella, additional, Di Roma, Mauro, additional, Dobrovie, Monica, additional, Focardi, Marta, additional, Gaibazzi, Nicola, additional, Gismondi, Annalaura, additional, Gravina, Matteo, additional, Guglielmo, Marco, additional, Lanzillo, Chiara, additional, Lombardi, Massimo, additional, Lorenzoni, Valentina, additional, Lozano-Torres, Jordi, additional, Margonato, Davide, additional, Martini, Chiara, additional, Marzo, Francesca, additional, Masci, Piergiorgio, additional, Masi, Ambra, additional, Memeo, Riccardo, additional, Moro, Claudio, additional, Mushtaq, Saima, additional, Nese, Alberto, additional, Palumbo, Alessandro, additional, Pavon, Anne Giulia, additional, Pedrotti, Patrizia, additional, Pepi, Mauro, additional, Perazzolo Marra, Martina, additional, Pica, Silvia, additional, Pradella, Silvia, additional, Presicci, Cristina, additional, Rabbat, Mark G, additional, Raineri, Claudia, additional, Rodriguez-Palomares, Jose’ F, additional, Sbarbati, Stefano, additional, Schoepf, U Joseph, additional, Squeri, Angelo, additional, Sverzellati, Nicola, additional, Symons, Rolf, additional, Tat, Emily, additional, Timpani, Mauro, additional, Todiere, Giancarlo, additional, Valentini, Adele, additional, Varga-Szemes, Akos, additional, Volpe, Alessandra, additional, Fusini, Laura, additional, Guaricci, Andrea Igoren, additional, Schwitter, Jurg, additional, and Pontone, Gianluca, additional

Published
2022
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34. Trabecular complexity as an early marker of cardiac involvement in Fabry disease

Author

Camporeale, Antonia, Moroni, Francesco, Lazzeroni, Davide, Garibaldi, Silvia, Pieroni, Maurizio, Pieruzzi, Federico, Lusardi, Paola, Spada, Marco, Mignani, Renzo, Burlina, Alessandro, Carubbi, Francesca, Econimo, Laura, Battaglia, Yuri, Graziani, Francesca, Pica, Silvia, Chow, Kelvin, Camici, Paolo G, Lombardi, Massimo, Graziani, Francesca (ORCID:0000-0002-4520-5689), Camporeale, Antonia, Moroni, Francesco, Lazzeroni, Davide, Garibaldi, Silvia, Pieroni, Maurizio, Pieruzzi, Federico, Lusardi, Paola, Spada, Marco, Mignani, Renzo, Burlina, Alessandro, Carubbi, Francesca, Econimo, Laura, Battaglia, Yuri, Graziani, Francesca, Pica, Silvia, Chow, Kelvin, Camici, Paolo G, Lombardi, Massimo, and Graziani, Francesca (ORCID:0000-0002-4520-5689)

Abstract

Aims Fabry cardiomyopathy is characterized by glycosphingolipid storage and increased myocardial trabeculation has also been demonstrated. This study aimed to explore by cardiac magnetic resonance whether myocardial trabecular complexity, quantified by endocardial border fractal analysis, tracks phenotype evolution in Fabry cardiomyopathy. Methods and results Study population included 20 healthy controls (12 males, age 32 +/- 9) and 45 Fabry patients divided into three groups: 15 left ventricular hypertrophy (LVH)-negative patients with normal T1 (5 males, age 28 +/- 13; Group 1); 15 LVH-negative patients with low T1 (9 males, age 33 +/- 9.6; Group 2); 15 LVH-positive patients (11 males, age 53.5 +/- 9.6; Group 3). Trabecular fractal dimensions (Dfs) (total, basal, mid-ventricular, and apical) were evaluated on cine images. Total Df was higher in all Fabry groups compared to controls, gradually increasing from controls to Group 3 (1.27 +/- 0.02 controls vs. 1.29 +/- 0.02 Group 1 vs. 1.30 +/- 0.02 Group 2 vs. 1.34 +/- 0.02 Group 3; P<0.001). Group 3 showed significantly higher values of all Dfs compared to the other Groups. Both basal and total Dfs were significantly higher in Group 1 compared with controls (basal: 1.30 +/- 0.03 vs. 1.26 +/- 0.04, P =0.010; total: 1.29 +/- 0.02 vs. 1.27 +/- 0.02, P=0.044). Total Df showed significant correlations with: (i) T1 value (r=-0.569; P<0.001); (ii) LV mass (r=0.664, P<0.001); (iii) trabecular mass (r=0.676; P <0.001); (iv) Mainz Severity Score Index (r=0.638; P<0.001). Conclusion Fabry cardiomyopathy is characterized by a progressive increase in Df of endocardial trabeculae together with shortening of T1 values. Myocardial trabeculation is increased before the presence of detectable sphingolipid storage, thus representing an early sign of cardiac involvement.

Published
2022

35. Trabecular complexity as an early marker of cardiac involvement in Fabry disease

Author

Camporeale, A, Moroni, F, Lazzeroni, D, Garibaldi, S, Pieroni, M, Pieruzzi, F, Lusardi, P, Spada, M, Mignani, R, Burlina, A, Carubbi, F, Econimo, L, Battaglia, Y, Graziani, F, Pica, S, Chow, K, Camici, P, Lombardi, M, Camporeale, Antonia, Moroni, Francesco, Lazzeroni, Davide, Garibaldi, Silvia, Pieroni, Maurizio, Pieruzzi, Federico, Lusardi, Paola, Spada, Marco, Mignani, Renzo, Burlina, Alessandro, Carubbi, Francesca, Econimo, Laura, Battaglia, Yuri, Graziani, Francesca, Pica, Silvia, Chow, Kelvin, Camici, Paolo G, Lombardi, Massimo, Camporeale, A, Moroni, F, Lazzeroni, D, Garibaldi, S, Pieroni, M, Pieruzzi, F, Lusardi, P, Spada, M, Mignani, R, Burlina, A, Carubbi, F, Econimo, L, Battaglia, Y, Graziani, F, Pica, S, Chow, K, Camici, P, Lombardi, M, Camporeale, Antonia, Moroni, Francesco, Lazzeroni, Davide, Garibaldi, Silvia, Pieroni, Maurizio, Pieruzzi, Federico, Lusardi, Paola, Spada, Marco, Mignani, Renzo, Burlina, Alessandro, Carubbi, Francesca, Econimo, Laura, Battaglia, Yuri, Graziani, Francesca, Pica, Silvia, Chow, Kelvin, Camici, Paolo G, and Lombardi, Massimo

Abstract

AIMS: Fabry cardiomyopathy is characterized by glycosphingolipid storage and increased myocardial trabeculation has also been demonstrated. This study aimed to explore by cardiac magnetic resonance whether myocardial trabecular complexity, quantified by endocardial border fractal analysis, tracks phenotype evolution in Fabry cardiomyopathy. METHODS AND RESULTS: Study population included 20 healthy controls (12 males, age 32±9) and 45 Fabry patients divided into three groups: 15 left ventricular hypertrophy (LVH)-negative patients with normal T1 (5 males, age 28±13; Group 1); 15 LVH-negative patients with low T1 (9 males, age 33±9.6; Group 2); 15 LVH-positive patients (11 males, age 53.5±9.6; Group 3). Trabecular fractal dimensions (Dfs) (total, basal, mid-ventricular, and apical) were evaluated on cine images. Total Df was higher in all Fabry groups compared to controls, gradually increasing from controls to Group 3 (1.27±0.02 controls vs. 1.29±0.02 Group 1 vs. 1.30±0.02 Group 2 vs. 1.34±0.02 Group 3; P<0.001). Group 3 showed significantly higher values of all Dfs compared to the other Groups. Both basal and total Dfs were significantly higher in Group 1 compared with controls (basal: 1.30±0.03 vs. 1.26±0.04, P =0.010; total: 1.29±0.02 vs. 1.27±0.02, P=0.044). Total Df showed significant correlations with: (i) T1 value (r=-0.569; P<0.001); (ii) LV mass (r=0.664, P<0.001); (iii) trabecular mass (r=0.676; P <0.001); (iv) Mainz Severity Score Index (r=0.638; P<0.001). CONCLUSION: Fabry cardiomyopathy is characterized by a progressive increase in Df of endocardial trabeculae together with shortening of T1 values. Myocardial trabeculation is increased before the presence of detectable sphingolipid storage, thus representing an early sign of cardiac involvement. Published on behalf of the European Society of Cardiology.

Published
2022

38. EACVI appropriateness criteria for the use of transthoracic echocardiography in adults: a report of literature and current practice review

Author

Steeds, Richard P., Garbi, Madalina, Cardim, Nuno, Kasprzak, Jaroslaw D., Sade, Elif, Nihoyannopoulos, Petros, Popescu, Bogdan Alexandru, Stefanidis, Alexandros, Cosyns, Bernard, Monaghan, Mark, Aakhus, Svend, Edvardsen, Thor, Flachskampf, Frank, Galiuto, Leonarda, Athanassopoulos, George, Lancellotti, Patrizio, Delgado, Victoria, Donal, Erwan, Galderisi, Maurizio, Lombardi, Massimo, Muraru, Denisa, and Haugaa, Kristina

Published
2017
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39. A joint procedural position statement on imaging in cardiac sarcoidosis: from the Cardiovascular and Inflammation & Infection Committees of the European Association of Nuclear Medicine, the European Association of Cardiovascular Imaging, and the American Society of Nuclear Cardiology

Author

Slart, Riemer H J A, Glaudemans, Andor W J M, Lancellotti, Patrizio, Hyafil, Fabien, Blankstein, Ron, Schwartz, Ronald G, Jaber, Wael A, Russell, Raymond, Gimelli, Alessia, Rouzet, François, Hacker, Marcus, Gheysens, Olivier, Plein, Sven, Miller, Edward J, Dorbala, Sharmila, Donal, Erwan, Sciagra, Roberto, Bucerius, Jan, Verberne, Hein J, Lindner, Oliver, Übleis, Christopher, Agostini, Denis, Signore, Alberto, Edvardsen, Thor, Neglia, Danilo, Beanlands, Rob S, Di Carli, Marcelo, Chareonthaitawee, Panithaya, Dilsizian, Vasken, Soman, Prem, Habib, Gilbert, Delgado, Victoria, Cardim, Nuno, Cosyns, Bernard, Flachskampf, Frank, Gerber, Bernhard, Haugaa, Kristina, Lombardi, Massimo, and Masci, Pier Giorgio

Published
2017
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42. 366 The use of dedicated long-axis views focused on the left atrium improves the accuracy of left atrial volumes and function measured by cardiovascular magnetic resonance

Author

Menè, Roberto, primary, Tondi, Lara, additional, Badano, Luigi, additional, Torlasco, Camilla, additional, Florescu, Diana Ruxandra, additional, Volpato, Valentina, additional, Parati, Gianfranco, additional, Giannattasio, Cristina, additional, Lombardi, Massimo, additional, and Muraru, Denisa, additional

Published
2021
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47. The multi-modality cardiac imaging approach to the Athleteʼs heart: an expert consensus of the European Association of Cardiovascular Imaging

Author

Galderisi, Maurizio, Cardim, Nuno, DʼAndrea, Antonello, Bruder, Oliver, Cosyns, Bernard, Davin, Laurent, Donal, Erwan, Edvardsen, Thor, Freitas, Antonio, Habib, Gilbert, Kitsiou, Anastasia, Plein, Sven, Petersen, Steffen E., Popescu, Bogdan A., Schroeder, Stephen, Burgstahler, Christof, Lancellotti, Patrizio, Sicari, Rosa, Muraru, Denisa, Lombardi, Massimo, Dulgheru, Raluca, and Gerche, Andre La

Published
2015
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48. Role of multimodality cardiac imaging in the management of patients with hypertrophic cardiomyopathy: an expert consensus of the European Association of Cardiovascular Imaging Endorsed by the Saudi Heart Association

Author

Cardim, Nuno, Galderisi, Maurizio, Edvardsen, Thor, Plein, Sven, Popescu, Bogdan A., DʼAndrea, Antonello, Bruder, Oliver, Cosyns, Bernard, Davin, Laurent, Donal, Erwan, Freitas, Antonio, Habib, Gilbert, Kitsiou, Anastasia, Petersen, Steffen E., Schroeder, Stephen, Lancellotti, Patrizio, Camici, Paolo, Dulgheru, Raluca, Hagendorff, Andreas, Lombardi, Massimo, Muraru, Denisa, and Sicari, Rosa

Published
2015
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49. Non-invasive cardiac imaging evaluation of patients with chronic systolic heart failure: a report from the European Association of Cardiovascular Imaging (EACVI)

Author

Gimelli, Alessia, Lancellotti, Patrizio, Badano, Luigi P., Lombardi, Massimo, Gerber, Bernhard, Plein, Sven, Neglia, Danilo, Edvardsen, Thor, Kitsiou, Anastasia, Scholte, Arthur J.H.A., Schröder, Stephen, Cosyns, Bernard, Gargiulo, Paola, Zamorano, Jose Luis, and Perrone-Filardi, Pasquale

Published
2014
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50. ECG-based score estimates the probability to detect Fabry Disease cardiac involvement

Author

Figliozzi, Stefano, Camporeale, Antonia, Boveri, Sara, Pieruzzi, Federico, Pieroni, Maurizio, Lusardi, Paola, Spada, Marco, Mignani, Renzo, Burlina, Alessandro, Graziani, Francesca, Pica, Silvia, Tondi, Lara, Bernardini, Andrea, Chow, Kelvin, Namdar, Mehdi, Lombardi, Massimo, Graziani, Francesca (ORCID:0000-0002-4520-5689), Figliozzi, Stefano, Camporeale, Antonia, Boveri, Sara, Pieruzzi, Federico, Pieroni, Maurizio, Lusardi, Paola, Spada, Marco, Mignani, Renzo, Burlina, Alessandro, Graziani, Francesca, Pica, Silvia, Tondi, Lara, Bernardini, Andrea, Chow, Kelvin, Namdar, Mehdi, Lombardi, Massimo, and Graziani, Francesca (ORCID:0000-0002-4520-5689)

Abstract

Objectives: To elaborate an ECG-based nomogram estimating the probability to detect cardiac involvement by cardiac magnetic resonance (CMR) in Fabry Disease (FD). Methods: 119 FD patients and 26 healthy controls underwent ECG and CMR. Test (n = 88, 60%) and validation cohorts (n = 57, 40%) were randomly derived. Cardiac involvement was defined as the presence of low myocardial T1 value, a CMR-surrogate of myocardial glycosphingolipid storage. ECG changes associated with low T1 value were identified in the test cohort, included in the nomogram and then tested in the validation cohort. Results: Sokolow-Lyon index (AUC = 0.769), ratio between P-wave and PR-segment durations (Pwave/PRsegment) (AUC = 0.778), QRS duration (AUC = 0.703), QT (AUC = 0.769) duration were independently associated with the presence of low T1 on CMR at multivariate analysis. An ECG-based nomogram including these four parameters was accurate in identifying patients with CMR evidence of glycosphingolipid storage (c-index of the derived-nomogram = 0.90 in the test group; 0.81 in the validation group). Conclusion: We propose a practical ECG-based nomogram accurately estimating the probability to detect low T1 values by CMR in FD patients. The application of this tool in clinical practice could improve early detection of FD cardiac involvement.

Published
2021

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