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1. Pluto's lower atmosphere and pressure evolution from ground-based stellar occultations, 1988-2016

Author

Meza, E., Sicardy, B., Assafin, M., Ortiz, J. L., Bertrand, T., Lellouch, E., Desmars, J., Forget, F., Bérard, D., Doressoundiram, A., Lecacheux, J., Oliveira, J. Marques, Roques, F., Widemann, T., Colas, F., Vachier, F., Renner, S., Leiva, R., Braga-Ribas, F., Benedetti-Rossi, G., Camargo, J. I. B., Dias-Oliveira, A., Morgado, B., Gomes-Júnior, A. R., Vieira-Martins, R., Behrend, R., Tirado, A. Castro, Duffard, R., Morales, N., Santos-Sanz, P., Jelínek, M., Cunniffe, R., Querel, R., Harnisch, M., Jansen, R., Pennell, A., Todd, S., Ivanov, V. D., Opitom, C., Gillon, M., Jehin, E., Manfroid, J., Pollock, J., Reichart, D. E., Haislip, J. B., Ivarsen, K. M., LaCluyze, A. P., Maury, A., Gil-Hutton, R., Dhillon, V., Littlefair, S., Marsh, T., Veillet, C., Bath, K. -L., Beisker, W., Bode, H. -J., Kretlow, M., Herald, D., Gault, D., Kerr, S., Pavlov, H., Faragó, O., Klös, O., Frappa, E., Lavayssière, M., Cole, A. A., Giles, A. B., Greenhill, J. G., Hill, K. M., Buie, M. W., Olkin, C. B., Young, E. F., Young, L. A., Wasserman, L. H., Devogèle, M., French, R. G., Bianco, F. B., Marchis, F., Brosch, N., Kaspi, S., Polishook, D., Manulis, I., Larbi, M. Ait Moulay, Benkhaldoun, Z., Daassou, A., Azhari, Y. El, Moulane, Y., Broughton, J., Milner, J., Dobosz, T., Bolt, G., Lade, B., Gilmore, A., Kilmartin, P., Allen, W. H., Graham, P. B., Loader, B., McKay, G., Talbot, J., Parker, S., Abe, L., Bendjoya, Ph., Rivet, J. -P., Vernet, D., Di Fabrizio, L., Lorenzi, V., Magazzù, A., Molinari, E., Gazeas, K., Tzouganatos, L., Carbognani, A., Bonnoli, G., Marchini, A., Leto, G., Sanchez, R. Zanmar, Mancini, L., Kattentidt, B., Dohrmann, M., Guhl, K., Rothe, W., Walzel, K., Wortmann, G., Eberle, A., Hampf, D., Ohlert, J., Krannich, G., Murawsky, G., Gährken, B., Gloistein, D., Alonso, S., Román, A., Communal, J. -E., Jabet, F., de Visscher, S., Sérot, J., Janik, T., Moravec, Z., Machado, P., Selva, A., Perelló, C., Rovira, J., Conti, M., Papini, R., Salvaggio, F., Noschese, A., Tsamis, V., Tigani, K., Barroy, P., Irzyk, M., Neel, D., Godard, J. P., Lanoiselée, D., Sogorb, P., Vérilhac, D., Bretton, M., Signoret, F., Ciabattari, F., Naves, R., Boutet, M., De Queiroz, J., Lindner, P., Lindner, K., Enskonatus, P., Dangl, G., Tordai, T., Eichler, H., Hattenbach, J., Peterson, C., Molnar, L. A., and Howell, R. R.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Context. Pluto's tenuous nitrogen (N2) atmosphere undergoes strong seasonal effects due to high obliquity and orbital eccentricity, and has been recently (July 2015) observed by the New Horizons spacecraft. Goals are (i) construct a well calibrated record of the seasonal evolution of surface pressure on Pluto and (ii) constrain the structure of the lower atmosphere using a central flash observed in 2015. Method: eleven stellar occultations by Pluto observed between 2002 and 2016 are used to retrieve atmospheric profiles (density, pressure, temperature) between $\sim$5 km and $\sim$380 km altitude levels (i.e. pressures from about 10 microbar to 10 nanobar). Results: (i) Pressure has suffered a monotonic increase from 1988 to 2016, that is compared to a seasonal volatile transport model, from which tight constraints on a combination of albedo and emissivity of N2 ice are derived; (ii) A central flash observed on 2015 June 29 is consistent with New Horizons REX profiles, provided that (a) large diurnal temperature variations (not expected by current models) occur over Sputnik Planitia and/or (b) hazes with tangential optical depth of about 0.3 are present at 4-7 km altitude levels and/or (c) the nominal REX density values are overestimated by an implausibly large factor of about 20% and/or (d) higher terrains block part of the flash in the Charon facing hemisphere., Comment: 21 pages, 11 figures

Published
2019
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2. The structure of Chariklo's rings from stellar occultations

Author

Bérard, D., Sicardy, B., Camargo, J. I. B., Desmars, J., Braga-Ribas, F., Ortiz, J. L., Duffard, R., Morales, N., Meza, E., Leiva, R., Benedetti-Rossi, G., Vieira-Martins, R., Gomes-Júnior, A. R., Assafin, M., Colas, F., Dauvergne, J. L., Kervella, P., Lecacheux, J., Maquet, L., Vachier, F., Renner, S., Monard, B., Sickafoose, A. A., Breytenbach, H., Genade, A., Beisker, W., Bath, K. L., Bode, H. J., Backes, M., Ivanov, V. D., Jehin, E., Gillon, M., Manfroid, J., Pollock, J., Tancredi, G., Roland, S., Salvo, R., Vanzi, L., Herald, D., Gault, D., Kerr, S., Pavlov, H., Hill, K. M., Bradshaw, J., Barry, M. A., Cool, A., Lade, B., Cole, A., Broughton, J., Newman, J., Horvart, R., Maybour, D., Giles, D., Davis, L., Paton, R. A., Loader, B., Pennell, A., Jaquiery, P. D., Brillant, S., Selman, F., Dumas, C., Herrera, C., Carraro, G., Monaco, L., Maury, A., Peyrot, A., Teng-Chuen-Yu, J. P., Richichi, A., Irawati, P., De Witt, C., Schoenau, P., Prager, R., Colazo, C., Melia, R., Spagnotto, J., Blain, A., Alonso, S., Román, A, Santos-Sanz, P., Rizos, J. L., Maestre, J. L., and Dunham, D.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Two narrow and dense rings (called C1R and C2R) were discovered around the Centaur object (10199) Chariklo during a stellar occultation observed on 2013 June 3. Following this discovery, we planned observations of several occultations by Chariklo's system in order to better characterize the physical properties of the ring and main body. Here, we use 12 successful occulations by Chariklo observed between 2014 and 2016. They provide ring profiles (physical width, opacity, edge structure) and constraints on the radii and pole position. Our new observations are currently consistent with the circular ring solution and pole position, to within the $\pm 3.3$ km formal uncertainty for the ring radii derived by Braga-Ribas et al. The six resolved C1R profiles reveal significant width variations from $\sim 5$ to 7.5 km. The width of the fainter ring C2R is less constrained, and may vary between 0.1 and 1 km. The inner and outer edges of C1R are consistent with infinitely sharp boundaries, with typical upper limits of one kilometer for the transition zone between the ring and empty space. No constraint on the sharpness of C2R's edges is available. A 1$\sigma$ upper limit of $\sim 20$ m is derived for the equivalent width of narrow (physical width <4 km) rings up to distances of 12,000 km, counted in the ring plane.

Published
2017
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3. Pluto's atmosphere from the 29 June 2015 ground-based stellar occultation at the time of the New Horizons flyby

Author

Sicardy, B., Talbot, J., Meza, E., Camargo, J. I. B., Desmars, J., Gault, D., Herald, D., Kerr, S., Pavlov, H., Braga-Ribas, F., Assafin, M., Benedetti-Rossi, G., Dias-Oliveira, A., Ramos-Gomes-Jr., A., Vieira-Martins, R., Berard, D., Kervella, P., Lecacheux, J., Lellouch, E., Beisker, W., Dunham, D., Jelinek, M., Duffard, R., Ortiz, J. L., Castro-Tirado, A. J., Cunniffe, R., Querel, R., Yock, P. A., Cole, A. A., Giles, A. B., Hill, K. M., Beaulieu, J. P., Harnisch, M., Jansen, R., Pennell, A., Todd, S., Allen, W. H., Graham, P. B., Loader, B., McKay, G., Milner, J., Parker, S., Barry, M. A., Bradshaw, J., Broughton, J., Davis, L., Devillepoix, H., Drummond, J., Field, L., Forbes, M., Giles, D., Glassey, R., Groom, R., Hooper, D., Horvat, R., Hudson, G., Idaczyk, R., Jenke, D., Lade, B., Newman, J., Nosworthy, P., Purcell, P., Skilton, P. F., Streamer, M., Unwin, M., Watanabe, H., White, G. L., and Watson, D.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We present results from a multi-chord Pluto stellar occultation observed on 29 June 2015 from New Zealand and Australia. This occurred only two weeks before the NASA New Horizons flyby of the Pluto system and serves as a useful comparison between ground-based and space results. We find that Pluto's atmosphere is still expanding, with a significant pressure increase of 5$\pm$2\% since 2013 and a factor of almost three since 1988. This trend rules out, as of today, an atmospheric collapse associated with Pluto's recession from the Sun. A central flash, a rare occurrence, was observed from several sites in New Zealand. The flash shape and amplitude are compatible with a spherical and transparent atmospheric layer of roughly 3~km in thickness whose base lies at about 4~km above Pluto's surface, and where an average thermal gradient of about 5 K~km$^{-1}$ prevails. We discuss the possibility that small departures between the observed and modeled flash are caused by local topographic features (mountains) along Pluto's limb that block the stellar light. Finally, using two possible temperature profiles, and extrapolating our pressure profile from our deepest accessible level down to the surface, we obtain a possible range of 11.9-13.7~$\mu$bar for the surface pressure., Comment: 16 pages, 2 tables, 3 figures

Published
2016
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4. Pluto's lower atmosphere and pressure evolution from ground-based stellar occultations, 1988-2016

Author

Meza, E, Sicardy, B, Assafin, M, Ortiz, JL, Bertrand, T, Lellouch, E, Desmars, J, Forget, F, Bérard, D, Doressoundiram, A, Lecacheux, J, Oliveira, JM, Roques, F, Widemann, T, Colas, F, Vachier, F, Renner, S, Leiva, R, Braga-Ribas, F, Benedetti-Rossi, G, Camargo, JIB, Dias-Oliveira, A, Morgado, B, Gomes-Júnior, AR, Vieira-Martins, R, Behrend, R, Tirado, AC, Duffard, R, Morales, N, Santos-Sanz, P, Jelínek, M, Cunniffe, R, Querel, R, Harnisch, M, Jansen, R, Pennell, A, Todd, S, Ivanov, VD, Opitom, C, Gillon, M, Jehin, E, Manfroid, J, Pollock, J, Reichart, DE, Haislip, JB, Ivarsen, KM, LaCluyze, AP, Maury, A, Gil-Hutton, R, Dhillon, V, Littlefair, S, Marsh, T, Veillet, C, Bath, K-L, Beisker, W, Bode, H-J, Kretlow, M, Herald, D, Gault, D, Kerr, S, Pavlov, H, Faragó, O, Klös, O, Frappa, E, Lavayssière, M, Cole, AA, Giles, AB, Greenhill, JG, Hill, KM, Buie, MW, Olkin, CB, Young, EF, Young, LA, Wasserman, LH, Devogèle, M, French, RG, Bianco, FB, Marchis, F, Brosch, N, Kaspi, S, Polishook, D, Manulis, I, Larbi, MAM, Benkhaldoun, Z, Daassou, A, Azhari, YE, Moulane, Y, Broughton, J, Milner, J, Dobosz, T, Bolt, G, Lade, B, Gilmore, A, Kilmartin, P, Allen, WH, Graham, PB, Loader, B, McKay, G, Talbot, J, Parker, S, Abe, L, Bendjoya, P, Rivet, J-P, Vernet, D, Fabrizio, LD, Lorenzi, V, Magazzù, A, Molinari, E, Gazeas, K, Tzouganatos, L, Carbognani, A, Bonnoli, G, Marchini, A, Leto, G, Sanchez, RZ, Mancini, L, Kattentidt, B, Dohrmann, M, Guhl, K, Rothe, W, Walzel, K, Wortmann, G, Eberle, A, Hampf, D, Ohlert, J, Krannich, G, Murawsky, G, Gährken, B, Gloistein, D, Alonso, S, Román, A, Communal, J-E, Jabet, F, Visscher, SD, Sérot, J, Janik, T, Moravec, Z, Machado, P, Selva, A, Perelló, C, Rovira, J, Conti, M, Papini, R, Salvaggio, F, Noschese, A, Tsamis, V, Tigani, K, Barroy, P, Irzyk, M, Neel, D, Godard, JP, Lanoiselée, D, Sogorb, P, Vérilhac, D, Bretton, M, Signoret, F, Ciabattari, F, Naves, R, Boutet, M, Queiroz, JD, Lindner, P, Lindner, K, Enskonatus, P, Dangl, G, Tordai, T, Eichler, H, Hattenbach, J, Peterson, C, Molnar, LA, and Howell, RR

Subjects
Earth and Planetary Astrophysics (astro-ph.EP), FOS: Physical sciences, Astrophysics - Earth and Planetary Astrophysics
Abstract

Context. Pluto's tenuous nitrogen (N2) atmosphere undergoes strong seasonal effects due to high obliquity and orbital eccentricity, and has been recently (July 2015) observed by the New Horizons spacecraft. Goals are (i) construct a well calibrated record of the seasonal evolution of surface pressure on Pluto and (ii) constrain the structure of the lower atmosphere using a central flash observed in 2015. Method: eleven stellar occultations by Pluto observed between 2002 and 2016 are used to retrieve atmospheric profiles (density, pressure, temperature) between $\sim$5 km and $\sim$380 km altitude levels (i.e. pressures from about 10 microbar to 10 nanobar). Results: (i) Pressure has suffered a monotonic increase from 1988 to 2016, that is compared to a seasonal volatile transport model, from which tight constraints on a combination of albedo and emissivity of N2 ice are derived; (ii) A central flash observed on 2015 June 29 is consistent with New Horizons REX profiles, provided that (a) large diurnal temperature variations (not expected by current models) occur over Sputnik Planitia and/or (b) hazes with tangential optical depth of about 0.3 are present at 4-7 km altitude levels and/or (c) the nominal REX density values are overestimated by an implausibly large factor of about 20% and/or (d) higher terrains block part of the flash in the Charon facing hemisphere., 21 pages, 11 figures

Published
2019

5. Lower atmosphere and pressure evolution on Pluto from ground-based stellar occultations, 1988-2016

Author

Meza, E. Sicardy, B. Assafin, M. Ortiz, J.L. Bertrand, T. Lellouch, E. Desmars, J. Forget, F. Bérard, D. Doressoundiram, A. Lecacheux, J. Marques Oliveira, J. Roques, F. Widemann, T. Colas, F. Vachier, F. Renner, S. Leiva, R. Braga-Ribas, F. Benedetti-Rossi, G. Camargo, J.I.B. Dias-Oliveira, A. Morgado, B. Gomes-Júnior, A.R. Vieira-Martins, R. Behrend, R. Castro Tirado, A. Duffard, R. Morales, N. Santos-Sanz, P. Jelínek, M. Cunniffe, R. Querel, R. Harnisch, M. Jansen, R. Pennell, A. Todd, S. Ivanov, V.D. Opitom, C. Gillon, M. Jehin, E. Manfroid, J. Pollock, J. Reichart, D.E. Haislip, J.B. Ivarsen, K.M. LaCluyze, A.P. Maury, A. Gil-Hutton, R. Dhillon, V. Littlefair, S. Marsh, T. Veillet, C. Bath, K.-L. Beisker, W. Bode, H.-J. Kretlow, M. Herald, D. Gault, D. Kerr, S. Pavlov, H. Faragó, O. Klös, O. Frappa, E. Lavayssière, M. Cole, A.A. Giles, A.B. Greenhill, J.G. Hill, K.M. Buie, M.W. Olkin, C.B. Young, E.F. Young, L.A. Wasserman, L.H. Devogèle, M. French, R.G. Bianco, F.B. Marchis, F. Brosch, N. Kaspi, S. Polishook, D. Manulis, I. Ait Moulay Larbi, M. Benkhaldoun, Z. Daassou, A. El Azhari, Y. Moulane, Y. Broughton, J. Milner, J. Dobosz, T. Bolt, G. Lade, B. Gilmore, A. Kilmartin, P. Allen, W.H. Graham, P.B. Loader, B. McKay, G. Talbot, J. Parker, S. Abe, L. Bendjoya, P. Rivet, J.-P. Vernet, D. Di Fabrizio, L. Lorenzi, V. Magazzú, A. Molinari, E. Gazeas, K. Tzouganatos, L. Carbognani, A. Bonnoli, G. Marchini, A. Leto, G. Zanmar Sanchez, R. Mancini, L. Kattentidt, B. Dohrmann, M. Guhl, K. Rothe, W. Walzel, K. Wortmann, G. Eberle, A. Hampf, D. Ohlert, J. Krannich, G. Murawsky, G. Gährken, B. Gloistein, D. Alonso, S. Román, A. Communal, J.-E. Jabet, F. DeVisscher, S. Sérot, J. Janik, T. Moravec, Z. MacHado, P. Selva, A. Perelló, C. Rovira, J. Conti, M. Papini, R. Salvaggio, F. Noschese, A. Tsamis, V. Tigani, K. Barroy, P. Irzyk, M. Neel, D. Godard, J.P. Lanoiselée, D. Sogorb, P. Vérilhac, D. Bretton, M. Signoret, F. Ciabattari, F. Naves, R. Boutet, M. De Queiroz, J. Lindner, P. Lindner, K. Enskonatus, P. Dangl, G. Tordai, T. Eichler, H. Hattenbach, J. Peterson, C. Molnar, L.A. Howell, R.R.

Abstract

Context. The tenuous nitrogen (N2) atmosphere on Pluto undergoes strong seasonal effects due to high obliquity and orbital eccentricity, and has recently (July 2015) been observed by the New Horizons spacecraft. Aims. The main goals of this study are (i) to construct a well calibrated record of the seasonal evolution of surface pressure on Pluto and (ii) to constrain the structure of the lower atmosphere using a central flash observed in 2015. Methods. Eleven stellar occultations by Pluto observed between 2002 and 2016 are used to retrieve atmospheric profiles (density, pressure, temperature) between altitude levels of ∼5 and ∼380 km (i.e. pressures from ∼10 μbar to 10 nbar). Results. (i) Pressure has suffered a monotonic increase from 1988 to 2016, that is compared to a seasonal volatile transport model, from which tight constraints on a combination of albedo and emissivity of N2 ice are derived. (ii) A central flash observed on 2015 June 29 is consistent with New Horizons REX profiles, provided that (a) large diurnal temperature variations (not expected by current models) occur over Sputnik Planitia; and/or (b) hazes with tangential optical depth of ∼0.3 are present at 4-7 km altitude levels; and/or (c) the nominal REX density values are overestimated by an implausibly large factor of ∼20%; and/or (d) higher terrains block part of the flash in the Charon facing hemisphere. © E. Meza et al. 2019.

Published
2019

6. The PHEMU15 catalogue and astrometric results of the Jupiter's Galilean satellite mutual occultation and eclipse observations made in 2014-2015

Author

Saquet, E. Emelyanov, N. Robert, V. Arlot, J.-E. Anbazhagan, P. Baillié, K. Bardecker, J. Berezhnoy, A.A. Bretton, M. Campos, F. Capannoli, L. Carry, B. Castet, M. Charbonnier, Y. Chernikov, M.M. Christou, A. Colas, F. Coliac, J.-F. Dangl, G. Dechambre, O. Delcroix, M. Dias-Oliveira, A. Drillaud, C. Duchemin, Y. Dunford, R. Dupouy, P. Ellington, C. Fabre, P. Filippov, V.A. Finnegan, J. Foglia, S. Font, D. Gaillard, B. Galli, G. Garlitz, J. Gasmi, A. Gaspar, H.S. Gault, D. Gazeas, K. George, T. Gorda, S.Y. Gorshanov, D.L. Gualdoni, C. Guhl, K. Halir, K. Hanna, W. Henry, X. Herald, D. Houdin, G. Ito, Y. Izmailov, I.S. Jacobsen, J. Jones, A. Kamoun, S. Kardasis, E. Karimov, A.M. Khovritchev, M.Y. Kulikova, A.M. Laborde, J. Lainey, V. Lavayssiere, M. Le Guen, P. Leroy, A. Loader, B. Lopez, O.C. Lyashenko, A.Y. Lyssenko, P.G. Machado, D.I. Maigurova, N. Manek, J. Marchini, A. Midavaine, T. Montier, J. Morgado, B.E. Naumov, K.N. Nedelcu, A. Newman, J. Ohlert, J.M. Oksanen, A. Pavlov, H. Petrescu, E. Pomazan, A. Popescu, M. Pratt, A. Raskhozhev, V.N. Resch, J.-M. Robilliard, D. Roschina, E. Rothenberg, E. Rottenborn, M. Rusov, S.A. Saby, F. Saya, L.F. Selvakumar, G. Signoret, F. Slesarenko, V.Y. Sokov, E.N. Soldateschi, J. Sonka, A. Soulie, G. Talbot, J. Tejfel, V.G. Thuillot, W. Timerson, B. Toma, R. Torsellini, S. Trabuco, L.L. Traverse, P. Tsamis, V. Unwin, M. Van Den Abbeel, F. Vandenbruaene, H. Vasundhara, R. Velikodsky, Y.I. Vienne, A. Vilar, J. Vugnon, J.-M. Wuensche, N. Zeleny, P.

Subjects
Physics::Space Physics, Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics
Abstract

During the 2014-2015 mutual events season, the Institut de Mécanique Céleste et de Calcul des Éphémérides (IMCCE), Paris, France, and the Sternberg Astronomical Institute (SAI), Moscow, Russia, led an international observation campaign to record ground-based photometric observations of Galilean moon mutual occultations and eclipses.We focused on processing the complete photometric observations data base to compute new accurate astrometric positions. We used our method to derive astrometric positions from the light curves of the events. We developed an accurate photometric model of mutual occultations and eclipses, while correcting for the satellite albedos, Hapke's light scattering law, the phase effect, and the limb darkening. We processed 609 light curves, and we compared the observed positions of the satellites with the theoretical positions from IMCCE NOE-5-2010-GAL satellite ephemerides and INPOP13c planetary ephemeris. The standard deviation after fitting the light curve in equatorial positions is ±24 mas, or 75 km at Jupiter. The rms (O-C) in equatorial positions is ±50 mas, or 150 km at Jupiter. © 2017 The Author(s).

Published
2018

7. Lower atmosphere and pressure evolution on Pluto from ground-based stellar occultations, 1988–2016

Author

Meza, E., primary, Sicardy, B., additional, Assafin, M., additional, Ortiz, J. L., additional, Bertrand, T., additional, Lellouch, E., additional, Desmars, J., additional, Forget, F., additional, Bérard, D., additional, Doressoundiram, A., additional, Lecacheux, J., additional, Oliveira, J. Marques, additional, Roques, F., additional, Widemann, T., additional, Colas, F., additional, Vachier, F., additional, Renner, S., additional, Leiva, R., additional, Braga-Ribas, F., additional, Benedetti-Rossi, G., additional, Camargo, J. I. B., additional, Dias-Oliveira, A., additional, Morgado, B., additional, Gomes-Júnior, A. R., additional, Vieira-Martins, R., additional, Behrend, R., additional, Tirado, A. Castro, additional, Duffard, R., additional, Morales, N., additional, Santos-Sanz, P., additional, Jelínek, M., additional, Cunniffe, R., additional, Querel, R., additional, Harnisch, M., additional, Jansen, R., additional, Pennell, A., additional, Todd, S., additional, Ivanov, V. D., additional, Opitom, C., additional, Gillon, M., additional, Jehin, E., additional, Manfroid, J., additional, Pollock, J., additional, Reichart, D. E., additional, Haislip, J. B., additional, Ivarsen, K. M., additional, LaCluyze, A. P., additional, Maury, A., additional, Gil-Hutton, R., additional, Dhillon, V., additional, Littlefair, S., additional, Marsh, T., additional, Veillet, C., additional, Bath, K.-L., additional, Beisker, W., additional, Bode, H.-J., additional, Kretlow, M., additional, Herald, D., additional, Gault, D., additional, Kerr, S., additional, Pavlov, H., additional, Faragó, O., additional, Klös, O., additional, Frappa, E., additional, Lavayssière, M., additional, Cole, A. A., additional, Giles, A. B., additional, Greenhill, J. G., additional, Hill, K. M., additional, Buie, M. W., additional, Olkin, C. B., additional, Young, E. F., additional, Young, L. A., additional, Wasserman, L. H., additional, Devogèle, M., additional, French, R. G., additional, Bianco, F. B., additional, Marchis, F., additional, Brosch, N., additional, Kaspi, S., additional, Polishook, D., additional, Manulis, I., additional, Ait Moulay Larbi, M., additional, Benkhaldoun, Z., additional, Daassou, A., additional, El Azhari, Y., additional, Moulane, Y., additional, Broughton, J., additional, Milner, J., additional, Dobosz, T., additional, Bolt, G., additional, Lade, B., additional, Gilmore, A., additional, Kilmartin, P., additional, Allen, W. H., additional, Graham, P. B., additional, Loader, B., additional, McKay, G., additional, Talbot, J., additional, Parker, S., additional, Abe, L., additional, Bendjoya, Ph., additional, Rivet, J.-P., additional, Vernet, D., additional, Di Fabrizio, L., additional, Lorenzi, V., additional, Magazzú, A., additional, Molinari, E., additional, Gazeas, K., additional, Tzouganatos, L., additional, Carbognani, A., additional, Bonnoli, G., additional, Marchini, A., additional, Leto, G., additional, Sanchez, R. Zanmar, additional, Mancini, L., additional, Kattentidt, B., additional, Dohrmann, M., additional, Guhl, K., additional, Rothe, W., additional, Walzel, K., additional, Wortmann, G., additional, Eberle, A., additional, Hampf, D., additional, Ohlert, J., additional, Krannich, G., additional, Murawsky, G., additional, Gährken, B., additional, Gloistein, D., additional, Alonso, S., additional, Román, A., additional, Communal, J.-E., additional, Jabet, F., additional, deVisscher, S., additional, Sérot, J., additional, Janik, T., additional, Moravec, Z., additional, Machado, P., additional, Selva, A., additional, Perelló, C., additional, Rovira, J., additional, Conti, M., additional, Papini, R., additional, Salvaggio, F., additional, Noschese, A., additional, Tsamis, V., additional, Tigani, K., additional, Barroy, P., additional, Irzyk, M., additional, Neel, D., additional, Godard, J. P., additional, Lanoiselée, D., additional, Sogorb, P., additional, Vérilhac, D., additional, Bretton, M., additional, Signoret, F., additional, Ciabattari, F., additional, Naves, R., additional, Boutet, M., additional, De Queiroz, J., additional, Lindner, P., additional, Lindner, K., additional, Enskonatus, P., additional, Dangl, G., additional, Tordai, T., additional, Eichler, H., additional, Hattenbach, J., additional, Peterson, C., additional, Molnar, L. A., additional, and Howell, R. R., additional

Published
2019
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8. The PHEMU15 catalogue and astrometric results of the Jupiter's Galilean satellite mutual occultation and eclipse observations made in 2014–2015

Author

Saquet, E, primary, Emelyanov, N, additional, Robert, V, additional, Arlot, J-E, additional, Anbazhagan, P, additional, Baillié, K, additional, Bardecker, J, additional, Berezhnoy, A A, additional, Bretton, M, additional, Campos, F, additional, Capannoli, L, additional, Carry, B, additional, Castet, M, additional, Charbonnier, Y, additional, Chernikov, M M, additional, Christou, A, additional, Colas, F, additional, Coliac, J-F, additional, Dangl, G, additional, Dechambre, O, additional, Delcroix, M, additional, Dias-Oliveira, A, additional, Drillaud, C, additional, Duchemin, Y, additional, Dunford, R, additional, Dupouy, P, additional, Ellington, C, additional, Fabre, P, additional, Filippov, V A, additional, Finnegan, J, additional, Foglia, S, additional, Font, D, additional, Gaillard, B, additional, Galli, G, additional, Garlitz, J, additional, Gasmi, A, additional, Gaspar, H S, additional, Gault, D, additional, Gazeas, K, additional, George, T, additional, Gorda, S Y, additional, Gorshanov, D L, additional, Gualdoni, C, additional, Guhl, K, additional, Halir, K, additional, Hanna, W, additional, Henry, X, additional, Herald, D, additional, Houdin, G, additional, Ito, Y, additional, Izmailov, I S, additional, Jacobsen, J, additional, Jones, A, additional, Kamoun, S, additional, Kardasis, E, additional, Karimov, A M, additional, Khovritchev, M Y, additional, Kulikova, A M, additional, Laborde, J, additional, Lainey, V, additional, Lavayssiere, M, additional, Le Guen, P, additional, Leroy, A, additional, Loader, B, additional, Lopez, O C, additional, Lyashenko, A Y, additional, Lyssenko, P G, additional, Machado, D I, additional, Maigurova, N, additional, Manek, J, additional, Marchini, A, additional, Midavaine, T, additional, Montier, J, additional, Morgado, B E, additional, Naumov, K N, additional, Nedelcu, A, additional, Newman, J, additional, Ohlert, J M, additional, Oksanen, A, additional, Pavlov, H, additional, Petrescu, E, additional, Pomazan, A, additional, Popescu, M, additional, Pratt, A, additional, Raskhozhev, V N, additional, Resch, J-M, additional, Robilliard, D, additional, Roschina, E, additional, Rothenberg, E, additional, Rottenborn, M, additional, Rusov, S A, additional, Saby, F, additional, Saya, L F, additional, Selvakumar, G, additional, Signoret, F, additional, Slesarenko, V Y, additional, Sokov, E N, additional, Soldateschi, J, additional, Sonka, A, additional, Soulie, G, additional, Talbot, J, additional, Tejfel, V G, additional, Thuillot, W, additional, Timerson, B, additional, Toma, R, additional, Torsellini, S, additional, Trabuco, L L, additional, Traverse, P, additional, Tsamis, V, additional, Unwin, M, additional, Abbeel, F Van Den, additional, Vandenbruaene, H, additional, Vasundhara, R, additional, Velikodsky, Y I, additional, Vienne, A, additional, Vilar, J, additional, Vugnon, J-M, additional, Wuensche, N, additional, and Zeleny, P, additional

Published
2017
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9. The Structure of Chariklo’s Rings from Stellar Occultations

Author

Bérard, D., primary, Sicardy, B., additional, Camargo, J. I. B., additional, Desmars, J., additional, Braga-Ribas, F., additional, Ortiz, J.-L., additional, Duffard, R., additional, Morales, N., additional, Meza, E., additional, Leiva, R., additional, Benedetti-Rossi, G., additional, Vieira-Martins, R., additional, Júnior, A.-R. Gomes, additional, Assafin, M., additional, Colas, F., additional, Dauvergne, J.-L., additional, Kervella, P., additional, Lecacheux, J., additional, Maquet, L., additional, Vachier, F., additional, Renner, S., additional, Monard, B., additional, Sickafoose, A. A., additional, Breytenbach, H., additional, Genade, A., additional, Beisker, W., additional, Bath, K.-L., additional, Bode, H.-J., additional, Backes, M., additional, Ivanov, V. D., additional, Jehin, E., additional, Gillon, M., additional, Manfroid, J., additional, Pollock, J., additional, Tancredi, G., additional, Roland, S., additional, Salvo, R., additional, Vanzi, L., additional, Herald, D., additional, Gault, D., additional, Kerr, S., additional, Pavlov, H., additional, Hill, K. M., additional, Bradshaw, J., additional, Barry, M. A., additional, Cool, A., additional, Lade, B., additional, Cole, A., additional, Broughton, J., additional, Newman, J., additional, Horvat, R., additional, Maybour, D., additional, Giles, D., additional, Davis, L., additional, Paton, R. A., additional, Loader, B., additional, Pennell, A., additional, Jaquiery, P.-D., additional, Brillant, S., additional, Selman, F., additional, Dumas, C., additional, Herrera, C., additional, Carraro, G., additional, Monaco, L., additional, Maury, A., additional, Peyrot, A., additional, Teng-Chuen-Yu, J.-P., additional, Richichi, A., additional, Irawati, P., additional, Witt, C. De, additional, Schoenau, P., additional, Prager, R., additional, Colazo, C., additional, Melia, R., additional, Spagnotto, J., additional, Blain, A., additional, Alonso, S., additional, Román, A., additional, Santos-Sanz, P., additional, Rizos, J.-L., additional, Maestre, J.-L., additional, and Dunham, D., additional

Published
2017
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10. ACTA OTORHINOLARYNGOLOGICA ITALICA

Author

Loader, B., primary, Linauer, I., additional, Korkesch, S., additional, Krammer-Effenberger, I., additional, Zielinski, V., additional, Schibany, N., additional, Kaider, A., additional, Vyskocil, E., additional, Tscholakoff, D., additional, and Franz, P., additional

Published
2016
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11. PLUTO’S ATMOSPHERE FROM THE 2015 JUNE 29 GROUND-BASED STELLAR OCCULTATION AT THE TIME OF THE NEW HORIZONS FLYBY

Author

Sicardy, B., primary, Talbot, J., additional, Meza, E., additional, Camargo, J. I. B., additional, Desmars, J., additional, Gault, D., additional, Herald, D., additional, Kerr, S., additional, Pavlov, H., additional, Braga-Ribas, F., additional, Assafin, M., additional, Benedetti-Rossi, G., additional, Dias-Oliveira, A., additional, Gomes-Júnior, A. R., additional, Vieira-Martins, R., additional, Bérard, D., additional, Kervella, P., additional, Lecacheux, J., additional, Lellouch, E., additional, Beisker, W., additional, Dunham, D., additional, Jelínek, M., additional, Duffard, R., additional, Ortiz, J. L., additional, Castro-Tirado, A. J., additional, Cunniffe, R., additional, Querel, R., additional, Yock, P. C., additional, Cole, A. A., additional, Giles, A. B., additional, Hill, K. M., additional, Beaulieu, J. P., additional, Harnisch, M., additional, Jansen, R., additional, Pennell, A., additional, Todd, S., additional, Allen, W. H., additional, Graham, P. B., additional, Loader, B., additional, McKay, G., additional, Milner, J., additional, Parker, S., additional, Barry, M. A., additional, Bradshaw, J., additional, Broughton, J., additional, Davis, L., additional, Devillepoix, H., additional, Drummond, J., additional, Field, L., additional, Forbes, M., additional, Giles, D., additional, Glassey, R., additional, Groom, R., additional, Hooper, D., additional, Horvat, R., additional, Hudson, G., additional, Idaczyk, R., additional, Jenke, D., additional, Lade, B., additional, Newman, J., additional, Nosworthy, P., additional, Purcell, P., additional, Skilton, P. F., additional, Streamer, M., additional, Unwin, M., additional, Watanabe, H., additional, White, G. L., additional, and Watson, D., additional

Published
2016
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13. Vibrant Soundbridge Chirurgie bei sensorineuraler und kombinierter Hörstörung bei Kindern und Erwachsenen

Author

Baumgartner, WD, Jappel, A, Starlinger, V, Loader, B, Arnoldner, C, and Gstöttner, W

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Das Vibrant Soundbridge semiimplantierbare Hörgerät ist bei intakter Ossikelkette, sowie bei Kettenunterbrechungen und Fehlbildungen indiziert. Ziel dieser Untersuchung ist die praktisch chirurgische Anwendung an ver-schiedenen Ankopplungsregionen im Mittelohr. Material und[for full text, please go to the a.m. URL], 82. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2010
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14. The PHEMU09 catalogue and astrometric results of the observations of the mutual occultations and eclipses of the Galilean satellites of Jupiter made in 2009

Author

Arlot, J. -E., Emelyanov, N., Varfolomeev, M. I., Amossé, A., Arena, C., Assafin, M., Barbieri, L., Bolzoni, S., Bragas-Ribas, F., Camargo, J. I. B., Casarramona, F., Casas, R., Christou, A., Colas, F., Collard, A., Combe, S., Constantinescu, M., Dangl, G., De, Cat, P., Degenhardt, S., Delcroix, M., Dias-Oliveira, A., Dourneau, G., Douvris, A., Druon, C., Ellington, C. K., Estraviz, G., Farissier, P., Farmakopoulos, A., Garlitz, J., Gault, D., George, T., Gorda, S. Y., Grismore, J., Guo, D. F., Herald, D., Ida, M., Ishida, M., Ivanov, A. V., Klemt, B., Koshkin, N., Le, Campion, J. F., Liakos, A., Liao, S. L., Li, S. N., Loader, B., Lopresti, C., Lo, Savio, E., Marchini, A., Marino, G., Masi, G., Massallé, A., Maulella, R., Mcfarland, J., Miyashita, K., Napoli, C., Noyelles, B., Pauwels, T., Pavlov, H., Peng, Q. Y., Perelló, C., Priban, V., Prost, J., Razemon, S., Rousselle, J. P., Rovira, J., Ruisi, R., Ruocco, N., Salvaggio, F., Sbarufatti, G., Shakun, L., Scheck, A., Sciuto, C., Da, Silva, Neto, D. N., V, Sinyaeva, N., Sofia, A., Sonka, A., Talbot, J., Tang, Z. H., Tejfel, V. G., Thuillot, W., Tigani, K., Timerson, B., Tontodonati, E., Tsamis, V., Unwin, M., Venable, R., Vieira-Martins, R., Vilar, J., Vingerhoets, P., Watanabe, H., Yin, H. X., Yu, Y., Zambelli, R., Arlot, J. -E., Emelyanov, N., Varfolomeev, M. I., Amossé, A., Arena, C., Assafin, M., Barbieri, L., Bolzoni, S., Bragas-Ribas, F., Camargo, J. I. B., Casarramona, F., Casas, R., Christou, A., Colas, F., Collard, A., Combe, S., Constantinescu, M., Dangl, G., De, Cat, P., Degenhardt, S., Delcroix, M., Dias-Oliveira, A., Dourneau, G., Douvris, A., Druon, C., Ellington, C. K., Estraviz, G., Farissier, P., Farmakopoulos, A., Garlitz, J., Gault, D., George, T., Gorda, S. Y., Grismore, J., Guo, D. F., Herald, D., Ida, M., Ishida, M., Ivanov, A. V., Klemt, B., Koshkin, N., Le, Campion, J. F., Liakos, A., Liao, S. L., Li, S. N., Loader, B., Lopresti, C., Lo, Savio, E., Marchini, A., Marino, G., Masi, G., Massallé, A., Maulella, R., Mcfarland, J., Miyashita, K., Napoli, C., Noyelles, B., Pauwels, T., Pavlov, H., Peng, Q. Y., Perelló, C., Priban, V., Prost, J., Razemon, S., Rousselle, J. P., Rovira, J., Ruisi, R., Ruocco, N., Salvaggio, F., Sbarufatti, G., Shakun, L., Scheck, A., Sciuto, C., Da, Silva, Neto, D. N., V, Sinyaeva, N., Sofia, A., Sonka, A., Talbot, J., Tang, Z. H., Tejfel, V. G., Thuillot, W., Tigani, K., Timerson, B., Tontodonati, E., Tsamis, V., Unwin, M., Venable, R., Vieira-Martins, R., Vilar, J., Vingerhoets, P., Watanabe, H., Yin, H. X., Yu, Y., and Zambelli, R.

Abstract

Context. In 2009, the Sun and the Earth passed through the equatorial plane of Jupiter and therefore the orbital planes of its main satellites. It was the equinox on Jupiter. This occurrence made mutual occultations and eclipses between the satellites possible. Experience has shown that the observations of such events provide accurate astrometric data able to bring new information on the dynamics of the Galilean satellites. Observations are made under the form of photometric measurements, but need to be made through the organization of a worldwide observation campaign maximizing the number and the quality of the data obtained. Aims. This work focuses on processing the complete database of photometric observations of the mutual occultations and eclipses of the Galilean satellites of Jupiter made during the international campaign in 2009. The final goal is to derive new accurate astrometric data. Methods. We used an accurate photometric model of mutual events adequate with the accuracy of the observation. Our original method was applied to derive astrometric data from photometric observations of mutual occultations and eclipses of the Galilean satellites of Jupiter. Results. We processed the 457 lightcurves obtained during the international campaign of photometric observations of the Galilean satellites of Jupiter in 2009. Compared with the theory, for successful observations, the r.m.s. of O-C residuals are equal to 45.8 mas and 81.1 mas in right ascension and declination, respectively; the mean O-C residuals are equal to -2 mas and -9 mas in right ascension and declination, respectively, for mutual occultations; and -6 mas and +1 mas in right ascension and declination, respectively, for mutual eclipses. © ESO, 2014.

Published
2014

15. The PHEMU09 catalogue and astrometric results of the observations of the mutual occultations and eclipses of the Galilean satellites of Jupiter made in 2009

Author

Arlot, J.-E., primary, Emelyanov, N., additional, Varfolomeev, M. I., additional, Amossé, A., additional, Arena, C., additional, Assafin, M., additional, Barbieri, L., additional, Bolzoni, S., additional, Bragas-Ribas, F., additional, Camargo, J. I. B., additional, Casarramona, F., additional, Casas, R., additional, Christou, A., additional, Colas, F., additional, Collard, A., additional, Combe, S., additional, Constantinescu, M., additional, Dangl, G., additional, De Cat, P., additional, Degenhardt, S., additional, Delcroix, M., additional, Dias-Oliveira, A., additional, Dourneau, G., additional, Douvris, A., additional, Druon, C., additional, Ellington, C. K., additional, Estraviz, G., additional, Farissier, P., additional, Farmakopoulos, A., additional, Garlitz, J., additional, Gault, D., additional, George, T., additional, Gorda, S. Yu., additional, Grismore, J., additional, Guo, D. F., additional, Herald, D., additional, Ida, M., additional, Ishida, M., additional, Ivanov, A. V., additional, Klemt, B., additional, Koshkin, N., additional, Le Campion, J. F., additional, Liakos, A., additional, Liao, S. L., additional, Li, S. N., additional, Loader, B., additional, Lopresti, C., additional, Lo Savio, E., additional, Marchini, A., additional, Marino, G., additional, Masi, G., additional, Massallé, A., additional, Maulella, R., additional, McFarland, J., additional, Miyashita, K., additional, Napoli, C., additional, Noyelles, B., additional, Pauwels, T., additional, Pavlov, H., additional, Peng, Q. Y., additional, Perelló, C., additional, Priban, V., additional, Prost, J., additional, Razemon, S., additional, Rousselle, J. P., additional, Rovira, J., additional, Ruisi, R., additional, Ruocco, N., additional, Salvaggio, F., additional, Sbarufatti, G., additional, Shakun, L., additional, Scheck, A., additional, Sciuto, C., additional, da Silva Neto, D. N., additional, V Sinyaeva, N., additional, Sofia, A., additional, Sonka, A., additional, Talbot, J., additional, Tang, Z. H., additional, Tejfel, V. G., additional, Thuillot, W., additional, Tigani, K., additional, Timerson, B., additional, Tontodonati, E., additional, Tsamis, V., additional, Unwin, M., additional, Venable, R., additional, Vieira-Martins, R., additional, Vilar, J., additional, Vingerhoets, P., additional, Watanabe, H., additional, Yin, H. X., additional, Yu, Y., additional, and Zambelli, R., additional

Published
2014
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16. Minor Planet Observations [244 Geocentic Occultation Observations]

Author

Herald, Dave, Abbeel, F., Aguirre, S., Anderson, P., Antos, M., Audejean, M., Bill, H., Blichfeldt, M., Bolt, G., Bolzoni, S., Bonnardeau, M., Bourtembourg, R., Bradshaw, J., Breit, D., Broughton, J., Bulder, H., Campbell, S., Campbell, T., Castro, E., Caton, D., Cejka, V., Christou, Apostolos, Clark, D., Correa, A., Coughlin, K., Dangl, G., Degenhardt, S., Dentel, M., Denzau, H., Dobosz, T., Durech, Josef, Enskonatus, P., Ewen-Smith, B. M., Farago, O., Fleishman, R., Frankenberger, R., Gabriel, P., Galád, Adrián, Gault, D., George, T., Goncalves, R., Goss, J., Groot, H., Halir, K., Harris, B., Hashimoto, A., Hayamizu, Tsutomu, Hofler, G., Ionov, S., Janik, T., Jindra, J., Kageyama, K., Kapetanakis, D., Kapka, M., Kapkov, V., Karasaki, H., Kerr, S., King, B., Kloes, O., Kopplin, J., Kordts, N., Koschny, Detlef, Krocil, M., Kusnirak, P., Ladanyi, T., Lecacheux, Jean, Leckmeyer, J., Leroy, A., Loader, B., Lohf, T., Lomoz, F., Macdougal, C., Majchrovic, I., Maley, Paul, Manek, J., Mcfarland, J., Mcgaha, J. E., Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Pôle Planétologie du LESIA, Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)

Subjects
[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

International audience

Published
2008

18. Astrometric results of observations of mutual occultations and eclipses of the Saturnian satellites in 2009

Author

Arlot, J.-E., primary, Emelyanov, N. V., additional, Lainey, V., additional, Andreev, M., additional, Assafin, M., additional, Braga-Ribas, F., additional, Camargo, J. I. B., additional, Casas, R., additional, Christou, A., additional, Colas, F., additional, Da Silva Neto, D. N., additional, Dechambre, O., additional, Dias-Oliveira, A., additional, Dourneau, G., additional, Farmakopoulos, A., additional, Gault, D., additional, George, T., additional, Gorshanov, D. L., additional, Herald, D., additional, Kozlov, V., additional, Kurenya, A., additional, Le Campion, J. F., additional, Lecacheux, J., additional, Loader, B., additional, Massallé, A., additional, Mc Brien, M., additional, Murphy, A., additional, Parakhin, N., additional, Roman-Lopes, A., additional, Schnabel, C., additional, Sergeev, A., additional, Tsamis, V., additional, Valdés Sada, P., additional, Vieira-Martins, R., additional, and Zhang, X., additional

Published
2012
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24. Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy.

Author

Enzenhofer E, Parzefall T, Haymerle G, Schneider S, Kadletz L, Heiduschka G, Pammer J, Oberndorfer F, Wrba F, Loader B, Grasl MC, Perisanidis C, and Erovic BM

Subjects
Adult, Aged, Biomarkers, Tumor metabolism, Carcinoma, Squamous Cell radiotherapy, Carcinoma, Squamous Cell surgery, Cyclin-Dependent Kinase Inhibitor p16 metabolism, Disease-Free Survival, Female, Head and Neck Neoplasms radiotherapy, Head and Neck Neoplasms surgery, Humans, Male, Middle Aged, Papillomaviridae pathogenicity, Papillomavirus Infections metabolism, Prospective Studies, Radiotherapy, Adjuvant methods, Signal Transduction physiology, Young Adult, Carcinoma, Squamous Cell metabolism, Head and Neck Neoplasms metabolism, Hedgehog Proteins metabolism
Abstract

Introduction: HPV positive patients suffering from head and neck cancer benefit from intensified radiotherapy when applied as a primary as well as an adjuvant treatment strategy. However, HPV negative patients treated with surgery and adjuvant radiotherapy lack validated prognostic biomarkers. It is therefore important to define prognostic biomarkers in this particular patient population. Especially, ´high-risk groups´ need to be defined in order to adapt treatment protocols. Since dysregulation of the sonic hedgehog pathway plays an important role in carcinogenesis, we aimed to assess whether members of the sonic hedgehog-signaling pathway may act as prognostic factors in patients with HPV negative head and neck squamous cell carcinoma., Materials and Methods: In this prospective study, pretreatment tumor biopsies of patients with head and neck squamous cell carcinoma were taken during panendoscopy (2005 to 2008). All patients were treated with surgery and postoperative radiotherapy. After assessment of HPV and p16 status, protein expression profiles of the Sonic hedgehog-signaling pathway were determined by immunohistochemistry and tissue microarray analyses in 36 HPV negative tumor biopsies. Expression profiles of Sonic hedgehog, Indian hedgehog, Patched, Smoothened, Gli-1, Gli-2 and Gli-3 were correlated with patients´ clinical data, local-control rate, disease-free as well as overall survival. Data from The Cancer Genome Atlas databank were used for external validation of our results., Results: Gli-1 (p = 0.04) and Gli-2 (p = 0.02) overexpression was significantly linked to improved overall survival of HPV negative patients. Gli-2 (p = 0.04) overexpression correlated significantly with prolonged disease-free survival. Cox-multivariate analysis showed that overexpression of Gli-2 correlated independently (HR 0.40, 95% CI 0.16-0.95, p = 0.03) with increased overall survival., Discussion: Gli-1 and Gli-2 overexpression represents a substantial prognostic factor for overall and disease-free survival in patients with locally advanced HPV negative head and neck cancer undergoing surgery and postoperative radiotherapy., Competing Interests: The authors have declared that no competing interests exist.

Published
2016
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25. A connection between neurovascular conflicts within the cerebellopontine angle and vestibular neuritis, a case controlled cohort study.

Author

Loader B, Linauer I, Korkesch S, Krammer-Effenberger I, Zielinski V, Schibany N, Kaider A, Vyskocil E, Tscholakoff D, and Franz P

Subjects
Arteries, Case-Control Studies, Cohort Studies, Female, Humans, Male, Middle Aged, Retrospective Studies, Vestibular Neuronitis diagnosis, Cerebellopontine Angle, Cerebellum blood supply, Vestibular Neuronitis etiology, Vestibulocochlear Nerve
Abstract

This retrospective, observer blinded case-control study aims to compare the prevalence of neurovascular conflicts (NVCs) of the vestibulocochlear nerve and the anterior inferior cerebellar artery (AICA) in patients presenting with clinical signs of acute vestibular neuritis with and without subsequent objective vestibular function loss (VFL). 58 acute cases of clinically suspected acute vestibular neuritis were investigated with same day cranial MRI at a tertiary referral centre and compared to 61 asymptomatic controls. The prevalence of NVCs in cases with objective VFL were also compared to cases without VFL. Radiologists described the NVC as "no contact" (Grade 0), "contact < 2 mm" (Grade 1), "contact > 2 mm" (Grade 2) and "vascular loop presence" (Grade 3) without knowledge of neurotological data. Neurotological data was collected without knowledge of MRI findings. Vestibular function was tested by bithermic caloric irrigation. 26 cases (45%) showed caloric VFL (Group A), whereas 32 (55%) exhibited no VFL (Group B). Group A included 13 cases with NVCs (50%), Group B included 26 NVC cases (82%) (p = 0.012) and the control group included 16 individuals (26%) (p < 0.001 for comparison of all 3 groups). Group B had a significantly higher NVC-Grading than Group A (p = 0.009). There was no statistically significant association between NVCs and either SNHL or tinnitus (p > 0.05). Our results suggest that patients presenting with clinical signs of acute vestibular neuritis who show symmetrical caloric vestibular function test results have a significantly higher NVC prevalence in the cerebellopontine angle., (© Copyright by Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale, Rome, Italy.)

Published
2016
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26. 7-Tesla MRI demonstrates absence of structural lesions in patients with vestibular paroxysmia.

Author

Rommer PS, Wiest G, Kronnerwetter C, Zach H, Loader B, Elwischger K, and Trattnig S

Abstract

Vestibular parxoysmia (VP) is a rare vestibular disorder. A neurovascular cross-compression (NVCC) between the vestibulochochlear nerve and an artery seems to be responsible for short attacks of vertigo in this entity. An NVCC can be seen in up to every fourth subject. The significance of these findings is not clear, as not all subjects suffer from symptoms. The aim of the present study was to assess possible structural lesions of the vestibulocochlear nerve by means of high field magnetic resonance imaging (MRI), and whether high field MRI may help to differentiate symptomatic from asymptomatic subjects. 7 Tesla MRI was performed in six patients with VP and confirmed NVCC seen on 1.5 and 3.0 MRI. No structural abnormalities were detected in any of the patients in 7 Tesla MRI. These findings imply that high field MRI does not help to differentiate between symptomatic and asymptomatic NVCC and that the symptoms of VP are not caused by structural nerve lesions. This supports the hypothesis that the nystagmus associated with VP has to be conceived pathophysiologically as an excitatory vestibular phenomenon, being not related to vestibular hypofunction. 7 Tesla MRI outperforms conventional MRI in image resolution and may be useful in vestibular disorders.

Published
2015
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27. Type of edema in posterior reversible encephalopathy syndrome depends on serum albumin levels: an MR imaging study in 28 patients.

Author

Pirker A, Kramer L, Voller B, Loader B, Auff E, and Prayer D

Subjects
Biomarkers blood, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Statistics as Topic, Brain Edema blood, Brain Edema diagnosis, Posterior Leukoencephalopathy Syndrome blood, Posterior Leukoencephalopathy Syndrome diagnosis, Serum Albumin analysis
Abstract

PRES is a clinicoradiologic entity, combining seizures, blindness, and coma with MR imaging findings of predominantly vasogenic and occasional cytotoxic edema. In this clinical report, we determined the type of edema by using DWI and FLAIR sequences on MR imaging as well as ADC maps in 28 patients with PRES. The neuradiologic findings were correlated with levels of serum albumin, which is a main contributor to colloid osmotic pressure and vascular integrity. The presence of vasogenic edema was significantly associated with decreased serum albumin levels, which may be a particular risk factor for the development of PRES.

Published
2011
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28. Reliability of health information on the Internet: an examination of experts' ratings.

Author

Craigie M, Loader B, Burrows R, and Muncer S

Subjects
Delivery of Health Care standards, Factor Analysis, Statistical, Humans, Information Services standards, Internet standards, Delivery of Health Care statistics & numerical data, Information Services statistics & numerical data, Internet statistics & numerical data, Physicians
Abstract

Background: The use of medical experts in rating the content of health-related sites on the Internet has flourished in recent years. In this research, it has been common practice to use a single medical expert to rate the content of the Web sites. In many cases, the expert has rated the Internet health information as poor, and even potentially dangerous. However, one problem with this approach is that there is no guarantee that other medical experts will rate the sites in a similar manner., Objectives: The aim was to assess the reliability of medical experts' judgments of threads in an Internet newsgroup related to a common disease. A secondary aim was to show the limitations of commonly-used statistics for measuring reliability (eg, kappa)., Methods: The participants in this study were 5 medical doctors, who worked in a specialist unit dedicated to the treatment of the disease. They each rated the information contained in newsgroup threads using a 6-point scale designed by the experts themselves. Their ratings were analyzed for reliability using a number of statistics: Cohen's kappa, gamma, Kendall's W, and Cronbach's alpha., Results: Reliability was absent for ratings of questions, and low for ratings of responses. The various measures of reliability used gave conflicting results. No measure produced high reliability., Conclusions: The medical experts showed a low agreement when rating the postings from the newsgroup. Hence, it is important to test inter-rater reliability in research assessing the accuracy and quality of health-related information on the Internet. A discussion of the different measures of agreement that could be used reveals that the choice of statistic can be problematic. It is therefore important to consider the assumptions underlying a measure of reliability before using it. Often, more than one measure will be needed for "triangulation" purposes.

Published
2002
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