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Your search keyword '"Liu, Lingpeng"' showing total 9 results
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9 results on '"Liu, Lingpeng"'

4. Safety and feasibility of laparoscopic left hepatectomy for the treatment of hepatolithiasis in patients with previous abdominal surgery

Author

Liu, Lingpeng, Huang, Yong, Ding, Zigang, Xu, Bangran, Luo, Dilai, Xiong, Hu, Liu, Hongliang, and Huang, Mingwen

Subjects
Laparoscopy, Medical research, Medicine, Experimental, Laparoscopic surgery, Health
Abstract

Byline: Lingpeng. Liu, Yong. Huang, Zigang. Ding, Bangran. Xu, Dilai. Luo, Hu. Xiong, Hongliang. Liu, Mingwen. Huang Background: The aim of the study was to compare the benefits and drawbacks [...]

Published
2022

7. Design, fabrication and clinical characterization of additively manufactured tantalum hip joint prosthesis

Author

Zhao, Dewei, Cheng, Liangliang, Lu, Faqiang, Zhang, Xiuzhi, Ying, Jiawei, Wei, Xiaowei, Cao, Fang, Ran, Chunxiao, Zheng, Guoshuang, Liu, Ge, Yi, Pinqiao, Wang, Haiyao, Song, Liqun, Wu, Bin, Liu, Lingpeng, Li, Lu, Wang, Xiaohu, and Li, Junlei

Abstract

The joint prosthesis plays a vital role in the outcome of total hip arthroplasty. The key factors that determine the performance of joint prostheses are the materials used and the structural design of the prosthesis. This study aimed to fabricate a porous tantalum (Ta) hip prosthesis using selective laser melting (SLM) technology. The feasibility of SLM Ta use in hip prosthesis was verified by studying its chemical composition, metallographic structure and mechanical properties. In vitroexperiments proved that SLM Ta exhibited better biological activities in promoting osteogenesis and inhibiting inflammation than SLM Ti6Al4V. Then, the topological optimization design of the femoral stem of the SLM Ta hip prosthesis was carried out by finite element simulation, and the fatigue performance of the optimized prosthesis was tested to verify the biomechanical safety of the prosthesis. A porous Ta acetabulum cup was also designed and fabricated using SLM. Its mechanical properties were then studied. Finally, clinical trials were conducted to verify the clinical efficacy of the SLM Ta hip prosthesis. The porous structure could reduce the weight of the prosthesis and stress shielding and avoid bone resorption around the prosthesis. In addition, anti-infection drugs can also be loaded into the pores for infection treatment. The acetabular cup can be custom-designed based on the severity of bone loss on the acetabular side, and the integrated acetabular cup can repair the acetabular bone defect while achieving the function of the acetabular cup.

Published
2024
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8. FAT10 mediates the sorafenib-resistance of hepatocellular carcinoma cells by stabilizing E3 ligase NEDD4 to enhance PTEN/AKT pathway-induced autophagy.

Author

Zhang W, Du D, Lu H, Zhang D, Liu L, Li J, Chen Z, Yu X, Ye M, Wang W, Chen L, and Shao J

Abstract

Although sorafenib is the first-line therapeutic agent for advanced hepatocellular carcinoma (HCC), the development of drug resistance in HCC cells limits its clinical efficacy. However, the key factors involved in mediating the sorafenib resistance of HCC cells and the underlying mechanisms have not been elucidated. In this study, we generated sorafenib-resistant HCC cell lines, and our data demonstrate that HLA-F locus-adjacent transcript 10 (FAT10), a ubiquitin-like protein, is markedly upregulated in sorafenib-resistant HCC cells and that reducing the expression of FAT10 in sorafenib-resistant HCC cells increases sensitivity to sorafenib. Mechanistically, FAT10 stabilizes the expression of the PTEN-specific E3 ubiquitin ligase NEDD4 that causes downregulation of PTEN, thereby inducing AKT-mediated autophagy and promoting the resistance of HCC cells to sorafenib. Moreover, we screened the small molecule Compound 7695-0983, which increases the sensitivity of sorafenib-resistant HCC cells to sorafenib by inhibiting the expression of FAT10 to inhibit NEDD4-PTEN/AKT axis-mediated autophagy. Collectively, our preclinical findings identify FAT10 as a key factor in the sorafenib resistance of HCC cells and elucidate its underlying mechanism. This study provides new mechanistic insight for the exploitation of novel sorafenib-based tyrosine kinase inhibitor (TKI)-targeted drugs for treating advanced HCC., Competing Interests: None., (AJCR Copyright © 2024.)

Published
2024
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9. Research progress and clinical translation of three-dimensional printed porous tantalum in orthopaedics.

Author

Ying J, Yu H, Cheng L, Li J, Wu B, Song L, Yi P, Wang H, Liu L, and Zhao D

Abstract

With continuous developments in additive manufacturing technology, tantalum (Ta) metal has been manufactured into orthopaedic implants with a variety of forms, properties and uses by three-dimensional printing. Based on extensive research in recent years, the design, processing and performance aspects of this new orthopaedic implant material have been greatly improved. Besides the bionic porous structure and mechanical characteristics that are similar to human bone tissue, porous tantalum is considered to be a viable bone repair material due to its outstanding corrosion resistance, biocompatibility, bone integration and bone conductivity. Numerous in vitro, in vivo, and clinical studies have been carried out in order to analyse the safety and efficacy of these implants in orthopaedic applications. This study reviews the most recent advances in manufacturing, characteristics and clinical application of porous tantalum materials.

Published
2023
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