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2. Splenectomy improves erythrocyte functionality in spherocytosis based on septin abundance, but not maturation defects

Author

Cloos, Anne-Sophie, Pollet, Hélène, Stommen, Amaury, Maja, Mauriane, Lingurski, Maxime, Brichard, Bénédicte, Lambert, Catherine, Henriet, Patrick, Pierreux, Christophe, Pyr dit Ruys, Sébastien, Van Der Smissen, Patrick, Vikkula, Miikka, Gatto, Laurent, Martin, Manon, Brouillard, Pascal, Vertommen, Didier, and Tyteca, Donatienne

Published
2023
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4. Splenectomy improves erythrocyte functionality in spherocytosis based on septin abundance but not maturation defects

Author

UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/CELL - Biologie cellulaire, UCL - SSS/DDUV/CBIO - Computational Biology and Bioinformatics, UCL - SSS/DDUV/GEHU - Génétique, UCL - SSS/DDUV/PHOS - Protein phosphorylation, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (SLuc) Service d'hématologie, UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, Cloos, Anne-Sophie, Pollet, Hélène, Stommen, Amaury, Maja, Mauriane, Lingurski, Maxime, Brichard, Bénédicte, Lambert, Catherine, Henriet, Patrick, Pierreux, Christophe, Pyr dit Ruys, Sébastien, Van Der Smissen, Patrick, Vikkula, Miikka, Gatto, Laurent, Martin, Manon, Brouillard, Pascal, Vertommen, Didier, Tyteca, Donatienne, UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/CELL - Biologie cellulaire, UCL - SSS/DDUV/CBIO - Computational Biology and Bioinformatics, UCL - SSS/DDUV/GEHU - Génétique, UCL - SSS/DDUV/PHOS - Protein phosphorylation, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (SLuc) Service d'hématologie, UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, Cloos, Anne-Sophie, Pollet, Hélène, Stommen, Amaury, Maja, Mauriane, Lingurski, Maxime, Brichard, Bénédicte, Lambert, Catherine, Henriet, Patrick, Pierreux, Christophe, Pyr dit Ruys, Sébastien, Van Der Smissen, Patrick, Vikkula, Miikka, Gatto, Laurent, Martin, Manon, Brouillard, Pascal, Vertommen, Didier, and Tyteca, Donatienne

Published
2023

5. Surface cholesterol-enriched domains specifically promote invasion of breast cancer cell lines by controlling invadopodia and extracellular matrix degradation

Author

UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/CELL - Biologie cellulaire, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SST/LIBST - Louvain Institute of Biomolecular Science and Technology, Maja, Mauriane, Mohammed, Danahe, Dumitru, Andra-Cristina, Verstraeten, Sandrine, Lingurski, Maxime, Mingeot-Leclercq, Marie-Paule, Alsteens, David, Tyteca, Donatienne, UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/CELL - Biologie cellulaire, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SST/LIBST - Louvain Institute of Biomolecular Science and Technology, Maja, Mauriane, Mohammed, Danahe, Dumitru, Andra-Cristina, Verstraeten, Sandrine, Lingurski, Maxime, Mingeot-Leclercq, Marie-Paule, Alsteens, David, and Tyteca, Donatienne

Abstract

Tumor cells exhibit altered cholesterol content. However, cholesterol structural subcellular distribution and implication in cancer cell invasion are unknown mainly due to difficulties to investigate cholesterol both quantitatively and qualitatively and to compare isogenic cell models. Here, using the MCF10A cell line series (non-tumorigenic MCF10A, pre-malignant MCF10AT and malignant MCF10CAIa cells) as a model of breast cancer progression and the highly invasive MDA-MB-231 cell line which exhibits the common TP53 mutation, we investigated if cholesterol contributes to cancer cell invasion, whether the effects are specific to cancer cells and the underlying mechanism. We found that partial membrane cholesterol depletion specifically and reversibly decreased invasion of the malignant cell lines. Those cells exhibited dorsal surface cholesterol-enriched submicrometric domains and narrow ER-plasma membrane and ER-intracellular organelles contact sites. Dorsal cholesterol-enriched domains can be endocytosed and reach the cell ventral face where they were involved in invadopodia formation and extracellular matrix degradation. In contrast, non-malignant cells showed low cell invasion, low surface cholesterol exposure and cholesterol-dependent focal adhesions. The differential cholesterol distribution and role in breast cancer cell invasion provide new clues for the understanding of the molecular events underlying cellular mechanisms in breast cancer.

Published
2022

6. Aberrant Membrane Composition and Biophysical Properties Impair Erythrocyte Morphology and Functionality in Elliptocytosis

Author

Pollet, Hélène, primary, Cloos, Anne-Sophie, additional, Stommen, Amaury, additional, Vanderroost, Juliette, additional, Conrard, Louise, additional, Paquot, Adrien, additional, Ghodsi, Marine, additional, Carquin, Mélanie, additional, Léonard, Catherine, additional, Guthmann, Manuel, additional, Lingurski, Maxime, additional, Vermylen, Christiane, additional, Killian, Theodore, additional, Gatto, Laurent, additional, Rider, Mark, additional, Pyr dit Ruys, Sébastien, additional, Vertommen, Didier, additional, Vikkula, Miikka, additional, Brouillard, Pascal, additional, Van Der Smissen, Patrick, additional, Muccioli, Giulio G., additional, and Tyteca, Donatienne, additional

Published
2020
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