8 results on '"Lind, Dorte Vesterholm"'
Search Results
2. Prenatal triclosan exposure and anthropometric measures including anogenital distance in Danish infants
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Lassen, Tina Harmer, Frederiksen, Hanne, Kyhl, Henriette Boye, Swan, Shanna H., Main, Katharina M., Andersson, Anna-Maria, Lind, Dorte Vesterholm, Husby, Steffen, Wohlfahrt-Veje, Christine, Skakkebaek, Niels E., and Jensen, Tina Kold
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Ultrasonic waves -- Usage ,Infants -- Health aspects ,Anthropometry -- Analysis ,Reproductive organs -- Physiological aspects ,Triclosan -- Usage ,Environmental issues ,Health - Abstract
BACKGROUND: Triclosan (TCS) is widely used as an antibacterial agent in consumer products such as hand soap and toothpaste, and human exposure is widespread. TCS is suspected of having endocrine-disrupting properties, but few human studies have examined the developmental effects of prenatal TCS exposure. OBJECTIVES: We prospectively examined associations between prenatal TCS exposure and anthropometric measures at birth and anogenital distance (AGD) at 3 months of age. METHODS: Pregnant women from the Odense Child Cohort (n = 514) provided urine samples at approximately gestational week 28 (median 28.7 weeks, range 26.4-34.0), and urinary TCS concentration was measured by isotope dilution TurboFlow-liquid chromatography-tandem mass spectrometry. Multiple linear regression analysis was used to examine associations between prenatal TCS exposure and measures of size at birth (birth weight, length, head and abdominal circumference) and AGD at 3 months of age (median 3.3 months, range 2.3-6.7 months), controlling for potential confounders. RESULTS: Newborn boys in the highest quartile of prenatal TCS exposure had a 0.7-cm [95% confidence interval (CI): -1.2, -0.1, p = 0.01] smaller head circumference than boys in the lowest quartile. Additionally in boys, inverse associations of borderline statistical significance were observed between prenatal TCS exposure and abdominal circumference at birth and AGD at 3 months of age (p-values < 0.10). Prenatal TCS exposure was not significantly associated with any of the outcomes in girls. However, AGD was measured in fewer girls, and we observed no significant interactions between a child's sex and prenatal TCS exposure in anthropometric measures at birth. CONCLUSION: Prenatal TCS exposure was associated with reduced head and abdominal circumference at birth and with reduced AGD at 3 months of age in boys, although the last two findings were statistically nonsignificant. These findings require replication but are compatible with an anti-androgenic effect of prenatal TCS exposure on fetal growth in boys. http://dx.doi.org/10.1289/ehp.1409637, Introduction Triclosan (TCS) is a biocide used as an antibacterial and antifungal agent in a number of consumer products such as toothpaste, mouthwash, disinfectants, and soaps (Dann and Hontela 2011). [...]
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- 2016
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3. Prenatal exposure to phthalates and anogenital distance in male infants from a low-exposed Danish cohort (2010-2012)
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Jensen, Tina Kold, Frederiksen, Hanne, Kyhl, Henriette Boye, Lassen, Tina Harmer, Swan, Shanna H., Bornehag, Carl-Gustaf, Skakkebaek, Niels E., Main, Katharina M., Lind, Dorte Vesterholm, Husby, Steffen, and Andersson, Anna-Maria
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Phthalates -- Health aspects -- Physiological aspects ,Prenatal influences -- Physiological aspects ,Male genitalia -- Abnormalities ,Environmental issues ,Health - Abstract
BACKGROUND: Phthalates comprise a large class of chemicals used in a variety of consumer products. Several have anti-androgenic properties, and in rodents prenatal exposure has been associated with reduced anogenital distance (AGD)--the distance from the anus to the genitals in male offspring. Few human studies have been conducted, but associations between the anti-androgenic phthalates and male AGD have been reported. OBJECTIVE: We aimed to study the association between phthalate exposure in late pregnancy in Danish women pregnant in 2010-2012 and AGD in their male infants at 3 months of age (n = 273). METHODS: In the Odense child cohort study, urinary concentrations of 12 phthalate metabolites of diethyl, di-n-butyl, diisobutyl, di(2-ethylhexyl), butylbenzyl, and diisononyl phthalate (DEP, DnBP, DiBP, DEHP, BBzP, and DiNP, respectively) were measured among 245 mothers of boys at approximately gestational week 28 (range, 20.4-30.4) and adjusted for osmolality. AGD, penile width, and weight were measured 3 months after the expected date of birth. Associations between prenatal phthalate and AGD and penile width were estimated using multivariable linear regression adjusting for age and weight-for-age standard deviation score. RESULTS: Phthalate levels were lower in this population than in a recent Swedish study in which phthalates were measured in the first trimester. No consistent associations were seen between any prenatal phthalate and AGD or penile width. Most associations were negative for exposures above the first quartile, and for ln-transformed exposures modeled as continuous variables, but there were no consistent dose-response patterns, and associations were not statistically significant (p > 0.05). CONCLUSION: We found no significant trends towards shorter AGD in boys with higher phthalates exposures in this low exposed Danish population. http://dx.doi.org/10.1289/ehp.1509870, Introduction Phthalates are used as plasticizers in soft polyvinyl chloride (PVC) and found in a large number of commonly used consumer products including food, building materials, plastics, cosmetics, cleaning products, [...]
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- 2016
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4. Prenatal exposure to antifungal medication may change anogenital distance in male offspring:a preliminary study
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Mogensen, Djamilla Madelung, Pihl, Maria Bergkvist, Skakkebæk, Niels Erik, Andersen, Helle Raun, Juul, Anders, Kyhl, Henriette Boye, Swan, Shanna, Kristensen, David Møbjerg, Andersen, Marianne Skovager, Lind, Dorte Vesterholm, Jensen, Tina Kold, Mogensen, Djamilla Madelung, Pihl, Maria Bergkvist, Skakkebæk, Niels Erik, Andersen, Helle Raun, Juul, Anders, Kyhl, Henriette Boye, Swan, Shanna, Kristensen, David Møbjerg, Andersen, Marianne Skovager, Lind, Dorte Vesterholm, and Jensen, Tina Kold
- Abstract
Background: Vaginal candidiasis is frequent among pregnant women and it is treated with anti-fungal medication (conazoles). Conazoles have anti-androgenic properties and prenatal exposure in rodents is associated with a shorter (less masculine) anogenital distance (AGD) in male offspring. To our knowledge this has never been studied in humans. Method: In the Odense Child Cohort pregnant women residing in Odense municipality, Denmark, were recruited at gestational age 8-16 weeks between 2010 and 2012. Of the eligible 2421 mother-child pairs, 812 mother-son pairs were included. Questionnaire data on medicine use were collected in first and third trimester and physical examination at age 3 month was performed. Ano-scrotal distance; measured from the centre of anus to the posterior base of scrotum (AGDas). Ano-cephalad distance; measured from the centre of anus to the cephalad insertion of the penis (AGDap) and penile width; measured at the base of the penis. Results: Eighty seven women had used antifungal medicine during pregnancy. Maternal use of oral fluconazole (n = 4) was associated with a 6.4 mm shorter AGDas (95% CI: -11.9;-0.9) in the male offspring. Use of antifungal vaginal tablets (n = 21), was associated with a non-significantly shorter AGDas (-1.9 mm; 95% CI: -4.3; 0.5) whereas exposure to vaginal cream (n = 23) was not associated to AGDas. Use of antifungal medicine in the window of genital development between 8 and 14 weeks of gestation was associated with a larger reduction in AGDas than exposure outside this window. Antifungal medicine intake was not associated with AGDap and penil width. Conclusion: Our preliminary findings prompted us to hypothesize that maternal use of conazole antifungal medication during pregnancy may affect the masculinization of male offspring. If confirmed, pregnant women should be advised to use antifungal medicine with caution.
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- 2017
5. Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort
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Lind, Dorte Vesterholm, Priskorn, Lærke, Lassen, Tina Harmer, Nielsen, Flemming, Kyhl, Henriette Boye, Kristensen, David Møbjerg, Christesen, Henrik Thybo, Steener Jørgensen, Jan, Grandjean, Philippe, Jensen, Tina Kold, Lind, Dorte Vesterholm, Priskorn, Lærke, Lassen, Tina Harmer, Nielsen, Flemming, Kyhl, Henriette Boye, Kristensen, David Møbjerg, Christesen, Henrik Thybo, Steener Jørgensen, Jan, Grandjean, Philippe, and Jensen, Tina Kold
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- 2017
6. Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons:a cohort study of 1027 mother-child pairs
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Lind, Dorte Vesterholm, Main, Katharina Maria, Kyhl, Henriette Boye, Kristensen, David Møbjerg, Toppari, Jorma, Andersen, Helle Raun, Skovsager Andersen, Marianne, Skakkebæk, Niels Erik, Jensen, Tina Kold, Lind, Dorte Vesterholm, Main, Katharina Maria, Kyhl, Henriette Boye, Kristensen, David Møbjerg, Toppari, Jorma, Andersen, Helle Raun, Skovsager Andersen, Marianne, Skakkebæk, Niels Erik, and Jensen, Tina Kold
- Abstract
STUDY QUESTION: Is maternal use of mild analgesics in pregnancy associated with anogenital distance (AGD)-the distance from the anus to the genitals-in the offspring?SUMMARY ANSWER: Maternal use of mild analgesics [especially simultaneous use of paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs)] during pregnancy was associated with a shorter AGD in boys whereas no effect was found in girls.WHAT IS KNOWN ALREADY: Mild analgesics including paracetamol (acetaminophen) and NSAIDs (e.g. ibuprofen and acetyl salicylic acid) have endocrine disrupting properties and in utero exposure reduces AGD in male rats. In humans, maternal exposure has been associated with cryptorchidism and hypospadias in male offspring but no studies have examined AGD.STUDY DESIGN, SIZE, DURATION: A prospective birth cohort study. Between 2010 and 2012, 2500 pregnant women were recruited from the Odense Child Cohort. Children were examined 3 months after the expected date of birth.PARTICIPANTS/MATERIALS, SETTING, METHODS: Pregnant women were asked about use of medication including mild analgesics (paracetamol and NSAID) during pregnancy at recruitment (gestational age (GA) week 10-27) and at GA week 28. AGD and penile width were measured 3 months after expected date of birth by trained personnel. A total of 1027 women answered both questionnaires and their children were examined. Associations between prenatal exposure to mild analgesics and AGD and penile width were estimated using multivariable linear regression adjusting for age and weight-for-age SD score.MAIN RESULTS AND THE ROLE OF CHANCE: A total of 40% of the women reported use of paracetamol and/or NSAIDs (4.4%) during the first 28 weeks of pregnancy. Exposure to analgesics during pregnancy was associated with a reduced AGD in boys, although statistically significant only for NSAIDs. The association was significant among 20 boys exposed to both paracetamol and NSAIDs (AGD -4.1 mm; CI 95%: -6.
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- 2017
7. Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary study
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Mogensen, Djamilla Madelung, primary, Pihl, Maria Bergkvist, additional, Skakkebæk, Niels E., additional, Andersen, Helle Raun, additional, Juul, Anders, additional, Kyhl, Henriette Boye, additional, Swan, Shanna, additional, Kristensen, David Møbjerg, additional, Andersen, Marianne Skovager, additional, Lind, Dorte Vesterholm, additional, and Jensen, Tina Kold, additional
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- 2017
- Full Text
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8. Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother–child pairs
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Lind, Dorte Vesterholm, primary, Main, Katharina M., additional, Kyhl, Henriette Boye, additional, Kristensen, David Møbjerg, additional, Toppari, Jorma, additional, Andersen, Helle Raun, additional, Andersen, Marianne Skovsager, additional, Skakkebæk, Niels E., additional, and Jensen, Tina Kold, additional
- Published
- 2016
- Full Text
- View/download PDF
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