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3. NF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer

Author

Wang, Shunyi, Kuai, Yihe, Lin, Simin, Li, Li, Gu, Quliang, Zhang, Xiaohan, Li, Xiaoming, He, Yajun, Chen, Sishuo, Xia, Xiaoru, Ruan, Zhang, Lin, Caixia, Ding, Yi, Zhang, Qianqian, Qi, Cuiling, Li, Jiangchao, He, Xiaodong, Pathak, Janak L., Zhou, Weijie, Liu, Side, Wang, Lijing, and Zheng, Lingyun

Published
2023
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5. SAP deletion promotes malignant insulinoma progression by inducing CXCL12 secretion from CAFs via the CXCR4/p38/ERK signalling pathway.

Author

Jiang, Guangchun, Xu, Shuo, Mai, Xiaobin, Tu, Juan, Wang, Le, Wang, Lijing, Zhan, Yaping, Wang, Yan, Zhang, Qianqian, Zheng, Lingyun, Li, Jiangchao, Tang, Pei, and Qi, Cuiling

Subjects
INSULINOMA, STROMAL cell-derived factor 1, CELLULAR signal transduction, NEUROENDOCRINE tumors, LIVER cells, LIVER proteins
Abstract

Malignant insulinoma is an extremely rare type of functioning pancreatic neuroendocrine tumour with a high degree of malignancy and a high incidence of metastasis. However, it is still unclear how malignant insulinomas develop and metastasize. Serum amyloid P component (SAP), a member of the pentraxin protein family, is an acute‐phase protein secreted by liver cells. The role of SAP in insulinoma and the related mechanism are still unknown. To determine the effect of SAP on insulinoma, we crossed Rip1‐Tag2 mice, which spontaneously develop insulinoma, and SAP knockout (KO) mice to generate Rip1‐Tag2;SAP−/− mice. We found that SAP deletion significantly promoted the growth, invasion and metastasis of malignant insulinoma through C‐X‐C motif chemokine ligand 12 (CXCL12) secreted by cancer‐associated fibroblasts (CAFs). Further study showed that SAP deletion promoted CXCL12 secretion by CAFs through the CXCR4/p38/ERK signalling pathway. These findings reveal a novel role and mechanism of SAP in malignant insulinoma and provide direct evidence that SAP may be a therapeutic agent for this disease. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Retraction: Inflammatory Molecule, PSGL-1, Deficiency Activates Macrophages to Promote Colorectal Cancer Growth through NFκB Signaling

Author

Li, Jiangchao, primary, Zhou, Zeqi, additional, Zhang, Xiaohan, additional, Zheng, Li, additional, He, Dan, additional, Ye, Yuxiang, additional, Zhang, Qian-Qian, additional, Qi, Cui-Ling, additional, He, Xiao-Dong, additional, Yu, Chen, additional, Shao, Chun-kui, additional, Qiao, Liang, additional, and Wang, Lijing, additional

Published
2022
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15. Characterization of 26 deletion CNVs reveals the frequent occurrence of micro-mutations within the breakpoint-flanking regions and frequent repair of double-strand breaks by templated insertions derived from remote genomic regions

Author

Wang, Ye, Su, Peiqiang, Hu, Bin, Zhu, Wenjuan, Li, Qibin, Yuan, Ping, Li, Jiangchao, Guan, Xinyuan, Li, Fucheng, Jing, Xiangyi, Li, Ru, Zhang, Yongling, Férec, Claude, Cooper, David N., Wang, Jun, Huang, Dongsheng, Chen, Jian-Min, and Wang, Yiming

Published
2015
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17. Clinical significance and biological role of cancer‐derived Type I collagen in lung and esophageal cancers

Author

Fang, Shuo, Dai, Yongdong, Mei, Yan, Yang, Mingming, Hu, Liang, Yang, Hong, Guan, Xininyuan, and Li, Jiangchao

Subjects
Male, non‐small cell lung cancer, Epithelial-Mesenchymal Transition, Lung Neoplasms, Esophageal Neoplasms, extracellular matrix, Mice, Nude, Adenocarcinoma, lcsh:RC254-282, Collagen Type I, Mice, Cell Movement, Carcinoma, Non-Small-Cell Lung, Biomarkers, Tumor, Tumor Cells, Cultured, Animals, Humans, tumor microenvironment, Type I collagen, Cell Proliferation, Retrospective Studies, Original Articles, Middle Aged, Prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Xenograft Model Antitumor Assays, Collagen Type I, alpha 1 Chain, Survival Rate, esophagus cancer, Case-Control Studies, Carcinoma, Squamous Cell, Original Article, Female, Follow-Up Studies
Abstract

Background Extracellular matrix (ECM) is remodeled during carcinogenesis. An abundant constituent of ECM is collagen. Type I collagen is secreted by fibroblasts, is important for tumor growth and epithelial‐mesenchymal transition, and may also be secreted by cancer cells. However, the role and function of cancer‐derived Type I collagen in the tumor microenvironment remains unclear. Methods We used immunohistochemistry and Western blot to detect Type I collagen expression in non‐small cell lung cancer (NSCLC) and esophageal squamous cell carcinoma (ESCC) cell lines, respectively. We assessed the migration and adhesion capability of these cells in vivo by inhibiting Type I collagen in tumors. Relevant data were extracted from a large cohort study of The Cancer Genome Atlas to analyze messenger RNA levels. Protein expression of Type I collagen was further determined in tumor tissues of patients using tissue microarray. Results Cancer cell lines secreted Type I collagen. The molecular weight of cancer‐derived Type I collagen was different from that secreted by cancer‐associated fibroblasts and normal fibroblasts. Expression levels of COL1A1 and COL1A2 (subtypes of Type I collagen) messenger RNA in NSCLC and ESCC tumors were higher than in normal tissues, but were not associated with tumor node metastasis stages. Low expression of Type I collagen was significantly associated with poor overall survival and cancer cell differentiation. Conclusion NSCLC and ESCC cells could produce Type I collagen endogenously, revealing the potential functions of Type I collagen in cancer development. Cancer‐derived Type I collagen was associated with overall survival and cancer cell differentiation.

Published
2019

19. Approach to Enhance Raman Shift Accuracy Based on a Real-Time Comparative Measurement Method

Author

Fei Li, Li Jiangchao, Xiang Ding, and Wenli Liu

Subjects
Accuracy and precision, Materials science, Silicon, chemistry.chemical_element, 02 engineering and technology, 01 natural sciences, law.invention, Monocrystalline silicon, symbols.namesake, Optics, law, Spectroscopy, Spectrometer, business.industry, 010401 analytical chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Laser, 0104 chemical sciences, Wavelength, chemistry, symbols, Measurement uncertainty, 0210 nano-technology, business, Raman spectroscopy
Abstract

A real-time comparative measurement method is proposed to enhance the measurement accuracy of Raman shifts. Several experimental configurations are presented and demonstrated. The error sources in Raman shifts are also analyzed. The method is tested on a Raman spectrometer by measuring a sample of monocrystalline silicon and a sample of polystyrene. Experimental results indicate that the accuracy limit of the method is 0.07 cm–1. The measurement uncertainty of the Raman shift of the silicon is 0.2 cm–1 (k = 2), and the measurement uncertainty of the polystyrene is also improved. It is shown that the real-time comparative measurement method can remarkably enhance the measurement accuracy of Raman shift, and it applies to Raman spectrometers regardless of whether their exact laser wavelengths are known or not.

Published
2018

21. Andrographolide Suppresses the Growth and Metastasis of Luminal-Like Breast Cancer by Inhibiting the NF-κB/miR-21-5p/PDCD4 Signaling Pathway

Author

Li, Junchen, primary, Huang, Lixun, additional, He, Zinan, additional, Chen, Minggui, additional, Ding, Yi, additional, Yao, Yuying, additional, Duan, Youfa, additional, Zixuan, Li, additional, Qi, Cuiling, additional, Zheng, Lingyun, additional, Li, Jiangchao, additional, Zhang, Rongxin, additional, Li, Xiaoming, additional, Dai, Jianwei, additional, Wang, Lijing, additional, and Zhang, Qian-Qian, additional

Published
2021
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24. LncRNA Gas5 Regulates Fn1 Deposition Via Creb5 in Renal Fibrosis

Author

Su, Huanhou, primary, Xie, Jingzhou, additional, Wen, Lijing, additional, Wang, Shunyi, additional, Chen, Sishuo, additional, Li, Jiangchao, additional, Qi, Cuiling, additional, Zhang, Qianqian, additional, He, Xiaodong, additional, Zheng, Lingyun, additional, and Wang, Lijing, additional

Published
2021
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25. Depression-/Anxiety-Like Behavior Alterations in Adult Slit2 Transgenic Mice

Author

Huang, Guilan, primary, Wang, Sheng, additional, Yan, Jie, additional, Li, Changxi, additional, Feng, Jianwen, additional, Chen, Qi, additional, Zheng, Xiaomeng, additional, Li, Huimin, additional, He, Yajun, additional, Young, Andrew J., additional, Li, Haobin, additional, Li, Weidong, additional, Li, Jiangchao, additional, and Wang, Lijing, additional

Published
2021
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30. Slit2/Robo1 Mitigates DSS-induced Ulcerative Colitis by Activating Autophagy in Intestinal Stem Cell

Author

Xie, Jingzhou, primary, Li, Li, additional, Deng, Shuhua, additional, Chen, Jiayuan, additional, Gu, Quliang, additional, Su, Huanhou, additional, Wen, Lijing, additional, Wang, Sheng, additional, Lin, Caixia, additional, Qi, Cuiling, additional, Zhang, Qianqian, additional, Li, Jiangchao, additional, He, Xiaodong, additional, Li, Weidong, additional, Wang, Lijing, additional, and Zheng, Lingyun, additional

Published
2020
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32. Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells

Author

Zhang, Chenzi, primary, He, Xiangjun, additional, Kwok, Yvonne K., additional, Wang, Feng, additional, Xue, Junyi, additional, Zhao, Hui, additional, Suen, Kin Wah, additional, Wang, Chi Chiu, additional, Ren, Jianwei, additional, Chen, George G., additional, Lai, Paul B. S., additional, Li, Jiangchao, additional, Xia, Yin, additional, Chan, Andrew M., additional, Chan, Wai-Yee, additional, and Feng, Bo, additional

Published
2018
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34. Inflammatory Molecule, PSGL-1, Deficiency Activates Macrophages to Promote Colorectal Cancer Growth through NFκB Signaling

Author

Li, Jiangchao, primary, Zhou, Zeqi, additional, Zhang, Xiaohan, additional, Zheng, Li, additional, He, Dan, additional, Ye, Yuxiang, additional, Zhang, Qian-Qian, additional, Qi, Cui-Ling, additional, He, Xiao-Dong, additional, Yu, Chen, additional, Shao, Chun-kui, additional, Qiao, Liang, additional, and Wang, Lijing, additional

Published
2017
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36. Abstract 722: Circulating EBV microRNA BART2-5p helps to diagnose nasopharyngeal carcinoma &lt screen for high risk individuals precisely

Author

Shang-Hang Xie, Lei Li, Su-Mei Cao, Xin Yuan Guan, Chen Jiang, and Li Jiangchao

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Cancer, Biology, Malignancy, medicine.disease, Serology, Nasopharyngeal carcinoma, Internal medicine, microRNA, Cancer research, medicine, TaqMan, Biomarker (medicine), Survival rate
Abstract

Nasopharyngeal carcinoma is an EB-virus associated malignancy which is highly prevalent in Southeast Asia. If diagnosed early, the 5 year disease-free survival rate is about 90%. However, most patients have already developed local or regional invasion when diagnosed, which results in poor prognosis. So it is essential to develop biomarkers to screen high risk individuals or diagnose the disease at early stages. As nasopharyngeal carcinoma is closely related to EBV infection and microRNAs encoded by BART region (BamHI A Rightward Transcripts) is abundant in NPC, we propose to identify biomarkers from those BART microRNAs. To quantify the copy number of microRNAs in serum samples, we used Taqman Probe-based qPCR. After adding Spiked-in Control (Mixture of Cel-39,Cel-54, Cel-238) to each 100ul serum sample, we extracted total RNA and reverse transcribed microRNA into cDNA with corresponding Taqman primers. Meanwhile, microRNA mimics with known copy number were serial diluted and reverse transcribed along with the samples. qPCR was performed to quantify the level of microRNAs in these samples with diluted cDNA and Taqman Probe. All data was normalized by Spiked-in controls and exact copy number of each microRNA was calculated through the standard curve generated by the serial diluted microRNA mimics. Here, we screened 17 BART microRNAs in discovery stage and found BART 2-5p as a candidate biomarker. In training cohort consisting of 266 patients with nasopharyngeal carcinoma and controls from Hong Kong, the sensitivity, specificity and AUC is 93.2%, 89.8%,0.976 respectively. The results are similar in validation cohort 1 constituted by 376 patients and controls from Guang Zhou. To evaluate the ability of BART 2-5p to distinguish preclinical NPC patients from healthy high risk individuals, we established a nested case-control study with serum samples prospectively collected from 10 NPC patients at least one year prior to their clinical diagnosis and 92 matched healthy high risk controls from a screening scheme conducted in South China. The sensitivity and specificity is 90.0% and 31.5%. Taken together, EBV microRNA BART2-5p is a promising biomarker to improve NPC diagnosis and target preclinical patients more precisely than serologic test. Citation Format: Chen Jiang, Lei Li, Li Jiangchao, Shang-hang Xie, Su-mei Cao, Xin-yuan Guan. Circulating EBV microRNA BART2-5p helps to diagnose nasopharyngeal carcinoma &lt screen for high risk individuals precisely [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 722. doi:10.1158/1538-7445.AM2017-722

Published
2017

40. P-selectin-mediated platelet adhesion promotes tumor growth

Author

Qi, Cuiling, primary, Wei, Bo, additional, Zhou, Weijie, additional, Yang, Yang, additional, Li, Bin, additional, Guo, Simei, additional, Li, Jialin, additional, Ye, Jie, additional, Li, Jiangchao, additional, Zhang, Qianqian, additional, Lan, Tian, additional, He, Xiaodong, additional, Cao, Liu, additional, Zhou, Jia, additional, Geng, Jianguo, additional, and Wang, Lijing, additional

Published
2015
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43. Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis

Author

Qi, Cuiling, primary, Zhou, Qin, additional, Li, Bin, additional, Yang, Yang, additional, Cao, Liu, additional, Ye, Yuxiang, additional, Li, Jiangchao, additional, Ding, Yi, additional, Wang, Huiping, additional, Wang, Jintao, additional, He, Xiaodong, additional, Zhang, Qianqian, additional, Lan, Tian, additional, Ka Ho Lee, Kenneth, additional, Li, Weidong, additional, Song, Xiaoyu, additional, Zhou, Jia, additional, Yang, Xuesong, additional, and Wang, Lijing, additional

Published
2014
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48. Characterization of Tumor Suppressive Function of cornulin in Esophageal Squamous Cell Carcinoma.

Author

Chen, Kai, Li, Yan, Dai, Yongdong, Li, Jiangchao, Qin, Yanru, Zhu, Yinghui, Zeng, Tingting, Ban, Xiaojiao, Fu, Li, and Guan, Xin-Yuan

Subjects
TUMOR suppressor genes, ESOPHAGEAL cancer, DNA microarrays, MESSENGER RNA, LYMPH node cancer, RNA interference, CANCER-related mortality, GENE silencing, PROGNOSIS
Abstract

By using cDNA microarray analysis, we identified cornulin (CRNN) gene was frequently downregulated in esophageal squamous cell carcinoma (ESCC). In the present study, we investigated the role of CRNN in ESCC development. The results showed that CRNN was frequently downregulated in primary ESCCs in both mRNA level (26/56, 46.4%) and protein level (137/249, 55%), which was significantly associated with lymph node metastases (P=0.027), advanced clinical stage (P=0.039), and overall survival rate (P<0.001). Multivariate analysis indicated that the CRNN downregulation was an independent prognostic factor for ESCC. Functional studies with both in vitro and in vivo assays demonstrated that CRNN had strong tumor suppressive ability in ESCC cells. The tumor-suppressive mechanism of CRNN was associated with its role in cell cycle arrest at G1/S checkpoint by upregulating expressions of P21WAF1/CIP1 and Rb. Silencing CRNN expression by RNA interference could effectively inhibit its tumor suppressive effect. In conclusion, our findings demonstrate that CRNN is a tumor suppressor gene that plays a critical tumor suppressive role in ESCC. [ABSTRACT FROM AUTHOR]

Published
2013
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49. Poly(G) 7 box: a functional element of mammalian 18S rRNA involved in translation.

Author

Wei D, Mai Z, Li X, Yu T, and Li J

Subjects
Humans, Animals, Nucleic Acid Conformation, Ribosomal Proteins metabolism, Ribosomal Proteins genetics, RNA, Messenger genetics, RNA, Messenger metabolism, Base Sequence, Guanine metabolism, Mammals genetics, RNA, Ribosomal, 18S metabolism, RNA, Ribosomal, 18S genetics, Protein Biosynthesis
Abstract

In eukaryotes, the ribosomal small subunit (40S) is composed of 18S rRNA and 33 ribosomal proteins. 18S rRNA has a special secondary structure and is an indispensable part of the translation process. Herein, a special sequence located in mammalian 18S rRNA named Poly(G) 7 box, which is composed of seven guanines, was found. Poly(G) 7 can form a special and stable secondary structure by binding to the translation elongation factor subunit eEF1D and the ribosomal protein RPL32. Poly(G) 7 box was transfected into cells, and the translation efficiency of cells was inhibited. We believe that Poly(G) 7 box is an important translation-related functional element located on mammalian 18S rRNA, meanwhile the Poly(G) 7 located on mRNA 5' and 3' box does not affect mRNA translation.

Published
2024
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50. [Type I collagen secreted by lung cancer cells promotes cancer cell growth in a three- dimensional culture system].

Author

Li J, Li X, Lan T, Qi C, He X, Yang H, Li Y, Wang L, and Guan X

Subjects
Cell Cycle, Cell Line, Tumor, Fibroblasts, Humans, Immunohistochemistry, RNA, Messenger, RNA, Small Interfering, Cell Proliferation, Collagen Type I metabolism, Lung Neoplasms metabolism
Abstract

Objective: To investigate the role of type I collagen as an autocrine protein in promoting the growth lung cancer cells in a three-dimensional (3D) culture system., Methods: Immunohistochemistry and RT-PCR were used to detect the expression of type I collagen in lung cancer specimens and 5 lung cancer cell lines. The lung cancer cell lines in 3D cultures were treated with vectors harboring short hairpin RNA (shRNA) targeting type I collagen, and the cell growth suppression was evaluated using MTT assay and colony formation assay. The lung cancer cells stimulated with supernatant from lung cancer-derived fibroblasts were tested for the expression of type I collagen mRNA., Results: Type I collagen expressions were detected in both the lung cancer tissues and the cell lines. In the 3D culture system, the growth of the cancer cell lines was obviously suppressed by shRNA-mediated type I collagen knockdown evidenced by lowered cell growth rate and colony formation ability. Stimulation with fibroblast culture supernatant resulted in enhanced expressions of type I collagen in the cancer cell lines., Conclusion: Autocrine of type I collagen I is required for maintaining lung cancer cell growth in 3D cultures, and its expression is regulated by fibroblasts. These findings provide new insights into the role of type I collagen I in the tumor microenvironment and point a new direction for targeted therapy of tumors.

Published
2014

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