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1. Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study

Author

Khan, Niloufer, Lindner, Sarah, Gomes, Antonio L.C., Devlin, Sean M., Shah, Gunjan L., Sung, Anthony D., Sauter, Craig S., Landau, Heather J., Dahi, Parastoo B., Perales, Miguel-Angel, Chung, David J., Lesokhin, Alexander M., Dai, Anqi, Clurman, Annelie, Slingerland, John B., Slingerland, Ann E., Brereton, Daniel G., Giardina, Paul A., Maloy, Molly, Armijo, Gabriel K., Rondon-Clavo, Carlos, Fontana, Emily, Bohannon, Lauren, Ramalingam, Sendhilnathan, Bush, Amy T., Lew, Meagan V., Messina, Julia A., Littmann, Eric, Taur, Ying, Jenq, Robert R., Chao, Nelson J., Giralt, Sergio, Markey, Kate A., Pamer, Eric G., van den Brink, Marcel R.M., and Peled, Jonathan U.

Published
2021
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2. The gut microbiota is associated with immune cell dynamics in humans

Author

Schluter, Jonas, Peled, Jonathan U., Taylor, Bradford P., Markey, Kate A., Smith, Melody, Taur, Ying, Niehus, Rene, Staffas, Anna, Dai, Anqi, Fontana, Emily, Amoretti, Luigi A., Wright, Roberta J., Morjaria, Sejal, Fenelus, Maly, Pessin, Melissa S., Chao, Nelson J., Lew, Meagan, Bohannon, Lauren, Bush, Amy, Sung, Anthony D., Hohl, Tobias M., Perales, Miguel-Angel, van den Brink, Marcel R. M., and Xavier, Joao B.

Published
2020
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3. Geriatric Assessment Reveals Actionable Impairments in Hematopoietic Stem Cell Transplantation Candidates Age 18 to 80 Years

Author

Lew, Meagan V., Ren, Yi, Lowder, Yen P., Siamakpour-Reihani, Sharareh, Ramalingam, Sendhilnathan, Romero, Kristi M., Thompson, Jillian C., Bohannon, Lauren M., McIntyre, Jackie, Tang, Helen, Van Opstal, Jolien, Johnson, Ernaya, Cohen, Harvey Jay, Bartlett, David B., Pastva, Amy M., Morey, Miriam, Hall, Katherine S., Smith, Patrick, Peters, Katherine B., Somers, Tamara J., Kelleher, Sarah, Smith, Sophia K., Wischmeyer, Paul E., Lin, Pao-Hwa, Wood, William A., Thorpe, Glynnis, Minor, Kerry, Wiggins, Kristi, Hennig, Therese, Helms, Tanya, Welch, Renee, Matthews, Brittany, Liu, JoAnn, Burleson, Jill, Aberant, Thomas, Engemann, Ashley K., Henshall, Bethany, Darby, Maurisa, Proch, Christina, Dellascio, Michelle, Pittman, Alyssa, Suminguit, Jacob, Choi, Taewoong, Gasparetto, Cristina, Long, Gwynn D., Lopez, Richard D., Sarantopoulos, Stefanie, Horwitz, Mitchell E., Chao, Nelson J., and Sung, Anthony D.

Published
2022
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4. Home-Based Hematopoietic Cell Transplantation in the United States

Author

Sung, Anthony D., Giri, Vinay K., Tang, Helen, Nichols, Krista Rowe, Lew, Meagan V., Bohannon, Lauren, Ren, Yi, Jung, Sin-Ho, Dalton, Tara, Bush, Amy, Van Opstal, Jolien, Artica, Alexandra, Messina, Julia, Shelby, Rebecca, Frith, Jennifer, Lassiter, Martha, Burleson, Jill, Leonard, Kari, Potter, Ashley S., Choi, Taewoong, Gasparetto, Cristina J., Horwitz, Mitchell E., Long, Gwynn D., Lopez, Richard D., Sarantopoulos, Stefanie, and Chao, Nelson J.

Published
2022
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5. A pilot study to assess the feasibility of a remotely monitored high-intensity interval training program prior to allogeneic hematopoietic stem cell transplantation.

Author

Artese, Ashley L., Winthrop, Hilary M., Bohannon, Lauren, Lew, Meagan V., Johnson, Ernaya, MacDonald, Grace, Ren, Yi, Pastva, Amy M., Hall, Katherine S., Wischmeyer, Paul E., Macleod, David, Molinger, Jeroen, Barth, Stratton, Jung, Sin-Ho, Cohen, Harvey Jay, Bartlett, David B., and Sung, Anthony D.

Subjects
HEMATOPOIETIC stem cell transplantation, HIGH-intensity interval training, PHYSICAL fitness, PHYSICAL mobility, CARDIOPULMONARY fitness, PILOT projects
Abstract

Introduction: Although allogeneic hematopoietic stem cell transplantation (HCT) can be a curative therapy for hematologic disorders, it is associated with treatment-related complications and losses in cardiorespiratory fitness and physical function. High-intensity interval training (HIIT) may be a practical way to rapidly improve cardiorespiratory fitness and physical function in the weeks prior to HCT. The primary aim of this study was to assess the feasibility of implementing a pre-HCT home-based HIIT intervention. The secondary aim was to evaluate pre to post changes in cardiorespiratory fitness and physical function following the intervention. Methods: This was a single-arm pilot study with patients who were scheduled to undergo allogeneic HCT within six months. Patients were instructed to complete three 30-minute home-based HIIT sessions/week between the time of study enrollment and sign-off for HCT. Sessions consisted of a 5-minute warm-up, 10 high and low intervals performed for one minute each, and a 5-minute cool-down. Prescribed target heart rates (HR) for the high- and low-intensity intervals were 80–90% and 50–60% of HR reserve, respectively. Heart rates during HIIT were captured via an Apple Watch and were remotely monitored. Feasibility was assessed via retention, session adherence, and adherence to prescribed interval number and intensities. Paired t-tests were used to compare changes in fitness (VO2peak) and physical function [Short Physical Performance Battery (SPPB), 30-second sit to stand, and six-minute walk test (6MWT)] between baseline and sign-off. Pearson correlations were used to determine the relationship between intervention length and changes in cardiorespiratory fitness or functional measures. Results: Thirteen patients (58.8±11.6 years) participated in the study, and nine (69.2%) recorded their training sessions throughout the study. Median session adherence for those nine participants was 100% (IQR: 87–107). Adherence to intervals was 92% and participants met or exceeded prescribed high-intensity HR on 68.8±34.8% of intervals. VO2peak improved from baseline to sign-off (14.6±3.1 mL/kg/min to 17.9±3.3 mL/kg/min; p<0.001). 30-second sit to stand and SPPB chair stand scores significantly improved in adherent participants. Improvements in 30-second sit to stand (13.8±1.5 to 18.3±3.3 seconds) and 6MWT (514.4±43.2 to 564.6±19.3) exceeded minimal clinically important improvements established in other chronic disease populations, representing the minimum improvement considered meaningful to patients. Conclusions: Findings demonstrate that implementing a pre-HCT home-based remotely monitored HIIT program is feasible and may provide benefits to cardiorespiratory fitness and physical function. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Decreased Mortality in 1-Year Survivors of Umbilical Cord Blood Transplant vs. Matched Related or Matched Unrelated Donor Transplant in Patients with Hematologic Malignancies

Author

Bohannon, Lauren, Tang, Helen, Page, Kristin, Ren, Yi, Jung, Sin-Ho, Artica, Alexandra, Britt, Anne, Islam, Prioty, Siamakpour-Reihani, Sharareh, Giri, Vinay, Lew, Meagan, Kelly, Matthew, Choi, Taewoong, Gasparetto, Cristina, Long, Gwynn, Lopez, Richard, Rizzieri, David, Sarantopoulos, Stefanie, Chao, Nelson, Horwitz, Mitchell, and Sung, Anthony

Published
2021
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7. Financial incentives to increase stool collection rates for microbiome studies in adult bone marrow transplant patients

Author

Thompson, Jillian C., primary, Ren, Yi, additional, Romero, Kristi, additional, Lew, Meagan, additional, Bush, Amy T., additional, Messina, Julia A., additional, Jung, Sin-Ho, additional, Siamakpour-Reihani, Sharareh, additional, Miller, Julie, additional, Jenq, Robert R., additional, Peled, Jonathan U., additional, van den Brink, Marcel R. M., additional, Chao, Nelson J., additional, Shrime, Mark G., additional, and Sung, Anthony D., additional

Published
2022
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9. The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD

Author

Markey, Kate A., primary, Schluter, Jonas, primary, Gomes, Antonio L. C., primary, Littmann, Eric R., primary, Pickard, Amanda J., primary, Taylor, Bradford P., primary, Giardina, Paul A., primary, Weber, Daniela, primary, Dai, Anqi, primary, Docampo, Melissa D., primary, Armijo, Gabriel K., primary, Slingerland, Ann E., primary, Slingerland, John B., primary, Nichols, Katherine B., primary, Brereton, Daniel G., primary, Clurman, Annelie G., primary, Ramos, Ruben J., primary, Rao, Arka, primary, Bush, Amy, primary, Bohannon, Lauren, primary, Covington, Megan, primary, Lew, Meagan V., primary, Rizzieri, David A., primary, Chao, Nelson, primary, Maloy, Molly, primary, Cho, Christina, primary, Politikos, Ioannis, primary, Giralt, Sergio, primary, Taur, Ying, primary, Pamer, Eric G., primary, Holler, Ernst, primary, Perales, Miguel-Angel, primary, Ponce, Doris M., primary, Devlin, Sean M., primary, Xavier, Joao, primary, Sung, Anthony D., primary, Peled, Jonathan U., primary, Cross, Justin R., primary, and van den Brink, Marcel R. M., primary

Published
2020
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10. Cognitive Impairment in Candidates for Allogeneic Hematopoietic Stem Cell Transplantation

Author

Smith, Patrick J., primary, Lew, Meagan, additional, Lowder, Yen P., additional, Romero, Kristi, additional, Thompson, Jill, additional, Bohannen, Lauren, additional, Pittman, Alyssa, additional, Sullivan, Keith, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Horwitz, Mitchell E., additional, Long, Gwynn D., additional, Lopez, Richard, additional, Rizzieri, David A., additional, Sarantopoulos, Stefanie, additional, Chao, Nelson J., additional, and Sung, Anthony D., additional

Published
2020
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11. Financial Incentives to Increase Stool Collection Rates for Microbiome Studies in Adult Bone Marrow Transplant Patients

Author

Thompson, Jillian, primary, Ren, Yi, additional, Romero, Kristi, additional, Lew, Meagan, additional, Bush, Amy, additional, Messina, Julia, additional, Jung, Sin-Ho, additional, Miller, Julie, additional, Zenko, Zachary, additional, Jenq, Robert R., additional, Peled, Jonathan U., additional, van den Brink, Marcel R.M., additional, Chao, Nelson J., additional, and Sung, Anthony D., additional

Published
2020
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12. Financial Incentives to Increase Stool Collection Rates for Microbiome Studies in Adult Bone Marrow Transplant Patients

Author

Thompson, Jillian C., primary, Ren, Yi, additional, Romero, Kristi M., additional, Lew, Meagan V., additional, Bush, Amy T., additional, Messina, Julia A., additional, Jung, Sin-Ho, additional, Miller, Julie M., additional, Zenko, Zachary, additional, Jenq, Robert R., additional, Peled, Jonathan U., additional, van den Brink, Marcel R.M., additional, Chao, Nelson J., additional, and Sung, Anthony D., additional

Published
2019
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13. Geriatric Assessment Identifies Impairments in Younger Candidates for Allogeneic Hematopoietic Stem Cell Transplantation

Author

Lew, Meagan V., primary, Ren, Yi, additional, Lowder, Yen P., additional, Romero, Kristi M., additional, Thompson, Jillian C., additional, Bohannon, Lauren M., additional, Cohen, Harvey, additional, Bartlett, David A., additional, Pastva, Amy M., additional, Morey, Miriam, additional, Hall, Katherine, additional, Smith, Patrick, additional, Peters, Katherine B., additional, Somers, Tamara, additional, Kelleher, Sarah, additional, Smith, Sophia, additional, Wischmeyer, Paul, additional, Lin, Pao-Hwa, additional, Thorpe, Glynnis, additional, Minor, Kerry, additional, Adler, Allison, additional, Wiggins, Kristi, additional, Hennig, Therese, additional, Helms, Tanya, additional, Welch, Renee, additional, Hicks, Whitney, additional, Eren, Margaret, additional, Porter, Rebecca, additional, Matthews, Brittany, additional, Liu, JoAnn, additional, Burleson, Jill, additional, Andrew, Whitney, additional, Aberant, Thomas, additional, Engemann, Ashley K., additional, Henshall, Bethany, additional, Darby, Maurisa, additional, Valea, Renea, additional, Proch, Christina, additional, Dellascio, Michelle, additional, Pittman, Alyssa, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Long, Gwynn D., additional, Lopez, Richard D., additional, Rizzieri, David A., additional, Sarantopoulos, Stefanie, additional, Horwitz, Mitchell E., additional, Chao, Nelson J., additional, and Sung, Anthony D., additional

Published
2019
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14. Decreased Mortality after the First Year of Allogeneic Hematopoietic Stem Cell Transplant in Recipients of Umbilical Cord Blood Vs. Matched Related or Matched Unrelated Donors

Author

Bohannon, Lauren M., primary, Page, Kristin M., additional, Ren, Yi, additional, Jung, Sin-Ho, additional, Giri, Vinay K., additional, Lew, Meagan V., additional, Kelly, Matthew, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Long, Gwynn D., additional, Lopez, Richard D., additional, Rizzieri, David A., additional, Sarantopoulos, Stefanie, additional, Chao, Nelson J., additional, Horwitz, Mitchell E., additional, and Sung, Anthony D., additional

Published
2019
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15. The gut microbiota influences how circulating immune cells in humans change from one day to the next

Author

Schluter, Jonas, Peled, Jonathan U., Taylor, Bradford P., Smith, Melody, Markey, Kate A., Taur, Ying, Niehus, Rene, Staffas, Anna, Dai, Anqi, Fontana, Emily, Amoretti, Luigi A., Wright, Roberta J., Morjaria, Sejal, Fenelus, Maly, Pessin, Melissa S., Chao, Nelson J., Lew, Meagan, Bohannon, Lauren, Bush, Amy, Sung, Anthony D., Hohl, Tobias M., Perales, Miguel-Angel, van den Brink, Marcel R.M., and Xavier, Joao B.

Subjects
bacteria, biochemical phenomena, metabolism, and nutrition
Abstract

The gut microbiota influences the development and homeostasis of the mammalian immune system 1–3 , can alter immune cell compositions in mice 4–7 , and is associated with responses to immunotherapy that rely on the activity of peripheral immune cells 8–12 . Still, our understanding of how the microbiota modulates circulatory immune cells remains limited, particularly in humans where a lack of manipulative experiments makes inference challenging. Here we overcome this challenge by studying hundreds of hospitalized—and closely monitored—bone marrow transplantation patients as they recover from chemotherapy-induced immune ablation. This aggressive treatment causes large shifts in both circulatory immune cell and microbiota populations, allowing the relationships between the two to be studied simultaneously over time with unprecedented resolution. We analyzed daily changes in white blood cell counts from 2,235 patients, and 10,680 longitudinal fecal microbiota samples to identify bacterial genera consistently associated with those changes. Bayesian inference and validation across different patient cohorts revealed consistent associations between intestinal bacteria and peripheral immune cell dynamics in the context of immunomodulatory medications, clinical metadata and homeostatic feedbacks between peripheral immune cells. The quantification of validated microbiota associations enabled us to contrast the potency of fermentatively active, obligate anaerobic bacteria with that of medications with known immunomodulatory mechanism, and this way estimate the microbiota potential to alter peripheral immune cell dynamics directly in patients. Our analysis establishes and quantifies the link between the intestinal microbiota and immune cell dynamics in humans, with implications for microbiota-driven modulation of immunity and immunotherapies that rely on circulatory immune cells.

Published
2019
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16. 539 - A Phase 1 Study of the Safety and Feasibility of Improving Cardiorespiratory Fitness through a Remotely Monitored, Mobile Health Supported High Intensity Interval Training Program (REMM-HIIT)

Author

Sung, Anthony D., Miller, Hilary M., Romero, Kristi, MacDonald, Grace, Bohannon, Lauren, Molinger, Jeroen, Ren, Yi, Bush, Amy, Lew, Meagan, Cohen, Harvey J, Pastva, Amy, Jung, Sin-Ho, Shah, Nirmish R, Smith, Patrick J, Wischmeyer, Paul E, Wood, William A, Alyea, Edwin, Choi, Taewoong, Gasparetto, Cristina, Horwitz, Mitchell E., Long, Gwynn D, Lopez, Richard D, Rizzieri, David A, Sarantopoulos, Stefanie, Sullivan, Keith M, Chao, Nelson J., and Bartlett, David B

Published
2021
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17. 56 - Fried’s Frailty Phenotype Predicts Overall Survival for Older Hematopoietic Cell Transplantation Recipients

Author

Sung, Anthony, Koll, Thuy, Gier, Shannon H., Lew, Meagan, Free, Marcia M, Bohannon, Lauren, Racioppi, Alessandro, Babushok, Daria V., Frey, Noelle V., Gill, Saar I., Hexner, Elizabeth O., Martin, Mary Ellen, Perl, Alexander E., Pratz, Keith W., Luger, Selina M., Stadtmauer, Edward A., Porter, David L., Loren, Alison W., Bhatt, Vijaya Raj, Gimotty, Phyllis, and McCurdy, Shannon R.

Published
2021
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18. A Phase 1 Study of the Safety and Feasibility of Improving Cardiorespiratory Fitness through a Remotely Monitored, Mobile Health Supported High Intensity Interval Training Program (REMM-HIIT)

Author

Sung, Anthony D., Miller, Hilary M., Romero, Kristi, MacDonald, Grace, Bohannon, Lauren, Molinger, Jeroen, Ren, Yi, Bush, Amy, Lew, Meagan, Cohen, Harvey J, Pastva, Amy, Jung, Sin-Ho, Shah, Nirmish R, Smith, Patrick J, Wischmeyer, Paul E, Wood, William A, Alyea, Edwin, Choi, Taewoong, Gasparetto, Cristina, Horwitz, Mitchell E., Long, Gwynn D, Lopez, Richard D, Rizzieri, David A, Sarantopoulos, Stefanie, Sullivan, Keith M, Chao, Nelson J., and Bartlett, David B

Published
2021
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19. Fried’s Frailty Phenotype Predicts Overall Survival for Older Hematopoietic Cell Transplantation Recipients

Author

Sung, Anthony, Koll, Thuy, Gier, Shannon H., Lew, Meagan, Free, Marcia M, Bohannon, Lauren, Racioppi, Alessandro, Babushok, Daria V., Frey, Noelle V., Gill, Saar I., Hexner, Elizabeth O., Martin, Mary Ellen, Perl, Alexander E., Pratz, Keith W., Luger, Selina M., Stadtmauer, Edward A., Porter, David L., Loren, Alison W., Bhatt, Vijaya Raj, Gimotty, Phyllis, and McCurdy, Shannon R.

Published
2021
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