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3. Correlates of Incident Cognitive Impairment in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study

Author

McClure, Leslie A., Wadley, Virginia G., Unverzagt, Frederick W., Cushman, Mary, Gillett, Sarah R., Thacker, Evan L., Letter, Abraham J., Kissela, Brett M., Kennedy, Richard E., Glasser, Stephen P., and Levine, Deborah A.

Abstract

Objective: To identify approximately 500 cases of incident cognitive impairment (ICI) in a large, national sample adapting an existing cognitive test-based case definition and to examine relationships of vascular risk factors with ICI. Method: Participants were from the REGARDS study, a national sample of 30,239 African-American and White Americans. Participants included in this analysis had normal cognitive screening and no history of stroke at baseline, and at least one follow-up cognitive assessment with a three-test battery (TTB). Regression-based norms were applied to TTB scores to identify cases of ICI. Logistic regression was used to model associations with baseline vascular risk factors. Results: We identified 495 participants with ICI of 17,630 eligible participants. In multivariable modeling, income (OR 1.83 CI 1.27,2.62), stroke belt residence (OR 1.45 CI 1.18,1.78), history of transient ischemic attack (OR 1.90 CI 1.29,2.81), coronary artery disease(OR 1.32 CI 1.02,1.70), diabetes (OR 1.48 CI 1.17,1.87), obesity (OR 1.40 CI 1.05,1.86), and incident stroke (OR 2.73 CI 1.52,4.90) were associated with ICI. Conclusions: We adapted a previously validated cognitive test-based case definition to identify cases of ICI. Many previously identified risk factors were associated with ICI, supporting the criterion-related validity of our definition.

Published
2015
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5. Abstract 106: Low Cognitive Scores in Domains of Learning, Memory or Executive Function Predict Incident Stroke: The REGARDS Study

Author

Wadley, Virginia G, primary, Thacker, Evan L, additional, Letter, Abraham J, additional, Unverzagt, Frederick W, additional, Moy, Claudia S, additional, Clark, David G, additional, McClure, Leslie A, additional, Howard, Virginia J, additional, Cushman, Mary, additional, Levine, Deborah A, additional, Kelley, Brendan J, additional, Kleindorfer, Dawn, additional, Kissela, Brett, additional, and Howard, George, additional

Published
2014
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7. High sodium:potassium intake ratio increases the risk for all-cause mortality: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study

Author

Judd, Suzanne E., primary, Aaron, Kristal J., additional, Letter, Abraham J., additional, Muntner, Paul, additional, Jenny, Nancy S., additional, Campbell, Ruth C., additional, Kabagambe, Edmond K., additional, Levitan, Emily B., additional, Levine, Deborah A., additional, Shikany, James M., additional, Safford, Monika, additional, and Lackland, Daniel T., additional

Published
2013
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12. Abstract P287: Sex Differences in Stroke Incidence: The REGARDS Study

Author

Howard, Virginia J, primary, Judd, Suzanne E, additional, Letter, Abraham J, additional, Kleindorfer, Dawn O, additional, McClure, Leslie A, additional, Safford, Monika M, additional, Rhodes, James D, additional, Cushman, Mary, additional, Moy, Claudia S, additional, Soliman, Elsayed S, additional, Kissela, Brett M, additional, and Howard, George, additional

Published
2012
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15. Abstract 106.

Author

Wadley, Virginia G, Thacker, Evan L, Letter, Abraham J, Unverzagt, Frederick W, Moy, Claudia S, Clark, David G, Mcclure, Leslie A, Howard, Virginia J, Cushman, Mary, Levine, Deborah A, Kelley, Brendan J, Kleindorfer, Dawn, Kissela, Brett, and Howard, George

Published
2014

16. Abstract WP445.

Author

Addison-Brown, Kristin J, Letter, Abraham J, Yaggi, Henry K, Mcclure, Leslie A, Unverzagt, Frederick W, Howard, Virginia J, Lichtman, Judith H, and Wadley, Virginia G

Published
2013

17. Abstract 2562.

Author

Howard, Virginia J, Letter, Abraham J, Mcclure, Leslie A, Howard, George, Cunningham, Solveig, Kleindorfer, Dawn O, Thrift, Amanda G, and Diez Rouz, Ana V

Published
2012

18. Abstract 183.

Author

Austin, Audrey L, Crowe, Michael G, Crowther, Martha R, Howard, Virginia J, Letter, Abraham J, Pulley, Leavonne, Scogin, Forrest R, Unverzagt, Frederick W, Vinson, Latrice D, and Wadley, Virginia G

Published
2012

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