Search

Your search keyword '"Leijtens, Jeroen W.A."' showing total 4 results
Start Over Author "Leijtens, Jeroen W.A." Search Limiters Available in Library Collection

Refine your results

4 results on '"Leijtens, Jeroen W.A."'

1. Upfront resection versus no resection of the primary tumor in patients with synchronous metastatic colorectal cancer: the randomized phase 3 CAIRO4 study conducted by the Dutch Colorectal Cancer Group and the Danish Colorectal Cancer Group

Author

van der Kruijssen, D.E.W., primary, Elias, S.G., additional, van de Ven, P.M., additional, van Rooijen, K.L., additional, Lam-Boer, J. ’t, additional, Mol, L., additional, Punt, C.J.A., additional, Sommeijer, D.W., additional, Tanis, P.J., additional, Nielsen, J.D., additional, Yilmaz, M.K., additional, Van Riel, J.M.G.H., additional, Wasowiz-Kemps, D.K., additional, Loosveld, O.J.L., additional, van der Schelling, G.P., additional, de Groot, J.W.B., additional, van Westreenen, H.L., additional, Jakobsen, H.L., additional, Fromm, A.L., additional, Hamberg, P., additional, Verseveld, M., additional, Jaensch, C., additional, Liposits, G.I., additional, van Duijvendijk, P., additional, Hadj, J. Oulad, additional, van der Hoeven, J.A.B., additional, Trajkovic, M., additional, de Wilt, J.H.W., additional, Koopman, M., additional, Vincent, Jeroen, additional, Wegdam, Johannes A., additional, Haberkorn, Brigitte C.M., additional, van der Harst, Erwin, additional, Hendriks, Mathijs P., additional, Schreurs, W.H. (Hermien), additional, Cense, Huib A., additional, Rietbroek, Ron C., additional, Gier, Marie-José de, additional, de Widt-Levert, Louise M., additional, van Breugel, Edwin A., additional, de Vos, Aad I., additional, Brosens, Rebecca P.M., additional, Doornebosch, P.G., additional, de Jongh, Felix E., additional, Vles, Wouter J., additional, den Boer, Marien O., additional, Leijtens, Jeroen W.A., additional, Gelderblom, A.J. (Hans), additional, Peeters, Koen C.M.J., additional, Kuenen, Bart C., additional, Pultrum, Bareld B., additional, van Dodewaard-de Jong, Joyce M., additional, Consten, Esther C.J., additional, van de Wouw, A.J. (Yes), additional, Konsten, J.L.M., additional, Hoekstra, R., additional, Lutke Holzik, Martijn F., additional, Vos, Allert H., additional, van Hoogstraten, M.J., additional, Schlesinger, Nis H., additional, Creemers, Geert-Jan, additional, de Hingh, Ignace H.J.T., additional, Kjær, Monica L., additional, Petersen, Lone N., additional, Seiersen, Michael, additional, Altaf, Rahim, additional, van Cruijsen, Hester, additional, HessL, Daniël A., additional, van Leeuwen-Snoeks, obke L., additional, Pronk, Apollo, additional, Baeten, Coen I.M., additional, van der Deure, Wendy M., additional, Bosscha, Koop, additional, Schut, Heidi, additional, Leclercq, W.K.G., additional, Simkens, L.H.J., additional, Reijnders, Koen, additional, van Arkel, Kees, additional, van Grevenstein, W.M.U. (Helma), additional, van de Ven, Anthony W.H., additional, Vuylsteke, Ronald J.C.L.M., additional, Kuijer, Philomeen, additional, Bakker, Sandra D., additional, Goei, Hauwy, additional, Helgason, Helgi H., additional, van Acker, Gijs J.D., additional, Temizkan, Mehmet, additional, van Tilburg, Marc W.A., additional, Gerhards, Michael F., additional, Kerver, E.D., additional, Gootjes, Elske, additional, Nieboer, Peter, additional, Bleeker, Wim A., additional, and Vink, G.R., additional

Published
2024
Full Text
View/download PDF

2. Abandonment of Routine Radiotherapy for Nonlocally Advanced Rectal Cancer and Oncological Outcomes

Author

Hazen, Sanne Marije J.A., Sluckin, Tania C., Intven, Martijn P.W., Beets, Geerard L., Beets-Tan, Regina G.H., Borstlap, Wernard A.A., Buffart, Tineke E., Buijsen, Jeroen, Burger, Jacobus W.A., Van Dieren, Susan, Furnée, Edgar J.B., Geijsen, E. Debby, Hompes, Roel, Horsthuis, Karin, Leijtens, Jeroen W.A., Maas, Monique, Melenhorst, Jarno, Nederend, Joost, Peeters, Koen C.M.J., Rozema, Tom, Tuynman, Jurriaan B., Verhoef, Cornelis, De Vries, Marianne, Van Westreenen, Henderik L., De Wilt, Johannes H.W., Zimmerman, David D.E., Marijnen, Corrie A.M., Tanis, Pieter J., Kusters, Miranda, Hazen, Sanne Marije J.A., Sluckin, Tania C., Intven, Martijn P.W., Beets, Geerard L., Beets-Tan, Regina G.H., Borstlap, Wernard A.A., Buffart, Tineke E., Buijsen, Jeroen, Burger, Jacobus W.A., Van Dieren, Susan, Furnée, Edgar J.B., Geijsen, E. Debby, Hompes, Roel, Horsthuis, Karin, Leijtens, Jeroen W.A., Maas, Monique, Melenhorst, Jarno, Nederend, Joost, Peeters, Koen C.M.J., Rozema, Tom, Tuynman, Jurriaan B., Verhoef, Cornelis, De Vries, Marianne, Van Westreenen, Henderik L., De Wilt, Johannes H.W., Zimmerman, David D.E., Marijnen, Corrie A.M., Tanis, Pieter J., and Kusters, Miranda

Abstract

Importance: Neoadjuvant short-course radiotherapy was routinely applied for nonlocally advanced rectal cancer (cT1-3N0-1M0 with >1 mm distance to the mesorectal fascia) in the Netherlands following the Dutch total mesorectal excision trial. This policy has shifted toward selective application after guideline revision in 2014. Objective: To determine the association of decreased use of neoadjuvant radiotherapy with cancer-related outcomes and overall survival at a national level. Design, Setting, and Participants: This multicenter, population-based, nationwide cross-sectional cohort study analyzed Dutch patients with rectal cancer who were treated in 2011 with a 4-year follow-up. A similar study was performed in 2021, analyzing all patients that were surgically treated in 2016. From these cohorts, all patients with cT1-3N0-1M0 rectal cancer and radiologically unthreatened mesorectal fascia were included in the current study. The data of the 2011 cohort were collected between May and October 2015, and the data of the 2016 cohort were collected between October 2020 and November 2021. The data were analyzed between May and October 2022. Main Outcomes and Measures: The main outcomes were 4-year local recurrence and overall survival rates. Results: Among the 2011 and 2016 cohorts, 1199 (mean [SD] age, 68 [11] years; 430 women [36%]) of 2095 patients (57.2%) and 1576 (mean [SD] age, 68 [10] years; 547 women [35%]) of 3057 patients (51.6%) had cT1-3N0-1M0 rectal cancer and were included, with proportions of neoadjuvant radiotherapy of 87% (2011) and 37% (2016). Four-year local recurrence rates were 5.8% and 5.5%, respectively (P =.99). Compared with the 2011 cohort, 4-year overall survival was significantly higher in the 2016 cohort (79.6% vs 86.4%; P <.001), with lower non-cancer-related mortality (13.8% vs 6.3%; P <.001). Conclusions and Relevance: The results of this cross-sectional study suggest that an absolute 50% reduction in radiotherapy use for nonlocally

Published
2024

3. Transanal minimally invasive surgery (TAMIS) versus endoscopic submucosal dissection (ESD) for resection of non-pedunculated rectal lesions (TRIASSIC study): Study protocol of a European multicenter randomised controlled trial

Author

MS MDL 1, Cancer, Dekkers, Nik, Boonstra, Jurjen J., Moons, Leon M.G., Hompes, Roel, Bastiaansen, Barbara A., Tuynman, Jurriaan B., Koch, Arjun D., Weusten, Bas L.A.M., Pronk, Apollo, Neijenhuis, Peter A., Westerterp, Marinke, Van Den Hout, Wilbert B., Langers, Alexandra M.J., Van Der Kraan, Jolein, Alkhalaf, Alaa, Lai, Jonathan Y.L., Ter Borg, Frank, Fabry, Hans, Halet, Eric, Schwartz, Matthijs P., Nagengast, Wouter B., Straathof, Jan Willem A., Ten Hove, Rogier W.R., Oterdoom, Leendert H., Hoff, Christiaan, Belt, Eric J.Th, Zimmerman, David D.E., Hadithi, Muhammed, Morreau, Hans, De Cuba, Erienne M.V., Leijtens, Jeroen W.A., Vasen, Hans F.A., Van Leerdam, Monique E., De Graaf, Eelco J.R., Doornebosch, Pascal G., Hardwick, James C.H., MS MDL 1, Cancer, Dekkers, Nik, Boonstra, Jurjen J., Moons, Leon M.G., Hompes, Roel, Bastiaansen, Barbara A., Tuynman, Jurriaan B., Koch, Arjun D., Weusten, Bas L.A.M., Pronk, Apollo, Neijenhuis, Peter A., Westerterp, Marinke, Van Den Hout, Wilbert B., Langers, Alexandra M.J., Van Der Kraan, Jolein, Alkhalaf, Alaa, Lai, Jonathan Y.L., Ter Borg, Frank, Fabry, Hans, Halet, Eric, Schwartz, Matthijs P., Nagengast, Wouter B., Straathof, Jan Willem A., Ten Hove, Rogier W.R., Oterdoom, Leendert H., Hoff, Christiaan, Belt, Eric J.Th, Zimmerman, David D.E., Hadithi, Muhammed, Morreau, Hans, De Cuba, Erienne M.V., Leijtens, Jeroen W.A., Vasen, Hans F.A., Van Leerdam, Monique E., De Graaf, Eelco J.R., Doornebosch, Pascal G., and Hardwick, James C.H.

Published
2020

4. The CARTS study: Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery

Author

Bökkerink, Guus M.J., De Graaf, Eelco J.R., Punt, Cornelis J.A., Nagtegaal, Iris D., Rütten, Heidi, Nuyttens, Joost J.M.E., Van Meerten, Esther, Doornebosch, Pascal G., Tanis, Pieter J., Derksen, Eric J., Dwarkasing, Roy S., Marijnen, Corrie A.M., Cats, Annemieke, Tollenaar, Rob A.E.M., De Hingh, Ignace H.J.T., Rutten, Harm J.T., Van Der Schelling, George P., Ten Tije, Albert J., Leijtens, Jeroen W.A., Lammering, Guido, Beets, Geerard L., Aufenacker, Theo J., Pronk, Apollo, Manusama, Eric R., Hoff, Christiaan, Bremers, Andreas J.A., Verhoef, Cornelelis, De Wilt, Johannes H.W., Bökkerink, Guus M.J., De Graaf, Eelco J.R., Punt, Cornelis J.A., Nagtegaal, Iris D., Rütten, Heidi, Nuyttens, Joost J.M.E., Van Meerten, Esther, Doornebosch, Pascal G., Tanis, Pieter J., Derksen, Eric J., Dwarkasing, Roy S., Marijnen, Corrie A.M., Cats, Annemieke, Tollenaar, Rob A.E.M., De Hingh, Ignace H.J.T., Rutten, Harm J.T., Van Der Schelling, George P., Ten Tije, Albert J., Leijtens, Jeroen W.A., Lammering, Guido, Beets, Geerard L., Aufenacker, Theo J., Pronk, Apollo, Manusama, Eric R., Hoff, Christiaan, Bremers, Andreas J.A., Verhoef, Cornelelis, and De Wilt, Johannes H.W.

Abstract

Background: The CARTS study is a multicenter feasibility study, investigating the role of rectum saving surgery for distal rectal cancer. Methods/Design. Patients with a clinical T1-3 N0 M0 rectal adenocarcinoma below 10 cm from the anal verge will receive neoadjuvant chemoradiation therapy (25 fractions of 2 Gy with concurrent capecitabine). Transanal Endoscopic Microsurgery (TEM) will be performed 8 - 10 weeks after the end of the preoperative treatment depending on the clinical response. Primary objective is to determine the number of patients with a (near) complete pathological response after chemoradiation therapy and TEM. Secondary objectives are the local recurrence rate and quality of life after this combined therapeutic modality. A three-step analysis will be performed after 20, 33 and 55 patients to ensure the feasibility of this treatment protocol. Discussion. The CARTS-study is one of the first prospective multicentre trials to investigate the role of a rectum saving treatment modality using chemoradiation therapy and local excision. The CARTS study is registered at clinicaltrials.gov (NCT01273051).

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results