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29 results on '"Lee, Do-Wan"'

16. Does the Apparent Diffusion Coefficient Value Predict Permanent Cerebral Ischemia/Reperfusion Injury in Rats?

Author

Kwon, Jae-Im, primary, Woo, Chul-Woong, additional, Kim, Kyung-Won, additional, Choi, Yoonseok, additional, Kim, Sang-Tae, additional, Kim, Yun Jae, additional, Kang, Jeeheon, additional, Lee, Do-Wan, additional, Tak, Eunyoung, additional, Kim, Jeong-Kon, additional, Jung, Seung-Chae, additional, Kim, Tae-Hyung, additional, and Woo, Dong-Cheol, additional

Published
2019
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17. Spatiotemporal heterogeneity of tumor vasculature during tumor growth and antiangiogenic treatment: MRI assessment using permeability and blood volume parameters

Author

Kim, Cherry, primary, Suh, Ji-Yeon, additional, Heo, Changhoe, additional, Lee, Chang Kyung, additional, Shim, Woo Hyun, additional, Park, Bum Woo, additional, Cho, Gyunggoo, additional, Lee, Do-Wan, additional, Woo, Dong-Cheol, additional, Kim, Sang-Yeob, additional, Kim, Yun Jae, additional, Bae, Dong-Jun, additional, and Kim, Jeong Kon, additional

Published
2018
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18. Symmetrical Location Characteristics of Corticospinal Tract Associated With Hand Movement in the Human Brain

Author

Lee, Dong-Hoon, Lee, Do-Wan, and Han, Bong-Soo

Subjects
Adult, Male, Brain Mapping, Pyramidal Tracts, Observational Study, Hand, Magnetic Resonance Imaging, Functional Laterality, Diffusion Tensor Imaging, Humans, Female, human activities, Cerebrum, Research Article
Abstract

The purpose of this study is to elucidate the symmetrical characteristics of corticospinal tract (CST) related with hand movement in bilateral hemispheres using probabilistic fiber tracking method. Seventeen subjects were participated in this study. Fiber tracking was performed with 2 regions of interest, hand activated functional magnetic resonance imaging (fMRI) results and pontomedullary junction in each cerebral hemisphere. Each subject's extracted fiber tract was normalized with a brain template. To measure the symmetrical distributions of the CST related with hand movement, the laterality and anteriority indices were defined in upper corona radiata (CR), lower CR, and posterior limb of internal capsule. The measured laterality and anteriority indices between the hemispheres in each different brain location showed no significant differences with P

Published
2016

21. Neurochemical Changes Associated with Stress-Induced Sleep Disturbance in Rats: In Vivo and In Vitro Measurements

Author

Lee, Do-Wan, primary, Chung, Seockhoon, additional, Yoo, Hyun Ju, additional, Kim, Su Jung, additional, Woo, Chul-Woong, additional, Kim, Sang-Tae, additional, Lee, Dong-Hoon, additional, Kim, Kyung Won, additional, Kim, Jeong-Kon, additional, Lee, Jin Seong, additional, Choi, Choong Gon, additional, Shim, Woo Hyun, additional, Choi, Yoonseok, additional, and Woo, Dong-Cheol, additional

Published
2016
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28. Investigation of the neuroprotective effects of bee-venom acupuncture in a mouse model of Parkinson’s disease by using immunohistochemistry and In-vivo1H magnetic resonance spectroscopy at 9.4 T

Author

Yoon, Moon-Hyun, Lee, Do-Wan, Kim, Hyun-Jin, Chung, Jin-Yeung, Doo, Ah-Reum, Park, Hi-Joon, Kim, Seung-Nam, and Choe, Bo-Young

Abstract

Neuroprotective therapeutics slows down the degeneration process in animal models of Parkinson’s disease (PD). The neuronal survival in PD animal models is often measured by using immunohistochemistry. However, dynamic changes in the pathology of the brain cannot be explored with this technique. Application of in-vivo1H magnetic resonance spectroscopy (1H MRS) can cover this shortcoming, as these techniques are non-invasive and can be repeated over time in the same animal. Thus, the sensitivity of both techniques to measure changes in the PD pathology was explored in an experiment studying the neuroprotective effects of the vigilance enhancer bee-venom (BV) in a mouse model of PD. The mice were pre-treated with 0.02-ml BV administered to the acupuncture point GB34 (Yangneungcheon) once every 3 days for 2 weeks. Three groups were classified as control, MPTP-intoxicated PD model and BV-treated mice. Outer volume suppression combined with the ultra-short echo-time STEAM (TE = 2.2 ms, TM = 20 ms, TR = 5000 ms) was used for localized in-vivo1H MRS. Based on the 1H MRS spectral analysis, substantial changes of the neurochemical profiles were evaluated in the three investigated groups. In particular, the glutamate complex (Glx)/creatine (Cr) ratio (7.72 ± 1.25) in the PD group was significantly increased compared to that in the control group (3.93 ± 2.21, P = 0.001). Compared to the baseline values, the Glx/Cr ratio of the BV-treated group was significantly decreased 2 weeks after MPTP intoxication (one-way ANOVA, p < 0.05). In conclusion, the present study demonstrated that neurochemical alterations occurred in the three groups and that the neuroprotective effects of the BV acupuncture in a mouse model of PD could be quantified by using immunohistochemistry and 1H MRS.

Published
2013
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29. In Vivo Measurement of Neurochemical Abnormalities in the Hippocampus in a Rat Model of Cuprizone-Induced Demyelination.

Author

Lee, Do-Wan, Kwon, Jae-Im, Woo, Chul-Woong, Heo, Hwon, Kim, Kyung Won, Woo, Dong-Cheol, Kim, Jeong Kon, and Lee, Dong-Hoon

Subjects
*PROTON magnetic resonance spectroscopy, *SPRAGUE Dawley rats, *DEMYELINATION, *HIPPOCAMPUS (Brain), *GABA, *MYELIN sheath diseases
Abstract

This study quantitatively measured the changes in metabolites in the hippocampal lesions of a rat model of cuprizone-induced demyelination as detected using in vivo 7 T proton magnetic resonance spectroscopy. Nineteen Sprague Dawley rats were randomly divided into two groups and fed a normal chow diet or cuprizone (0.2%, w/w) for 7 weeks. Demyelinated hippocampal lesions were quantitatively measured using a 7 T magnetic resonance imaging scanner. All proton spectra were quantified for metabolite concentrations and relative ratios. Compared to those in the controls, the cuprizone-induced rats had significantly higher concentrations of glutamate (p = 0.001), gamma-aminobutyric acid (p = 0.019), and glutamate + glutamine (p = 0.001); however, creatine + phosphocreatine (p = 0.006) and myo-inositol (p = 0.001) concentrations were lower. In addition, we found that the glutamine and glutamate complex/total creatine (p < 0.001), glutamate/total creatine (p < 0.001), and GABA/total creatine (p = 0.002) ratios were significantly higher in cuprizone-treated rats than in control rats. Our results showed that cuprizone-induced neuronal demyelination may influence the severe abnormal metabolism in hippocampal lesions, and these responses could be caused by microglial activation, mitochondrial dysfunction, and astrocytic necrosis. [ABSTRACT FROM AUTHOR]

Published
2021
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