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454 results on '"Laskin, J."'

1. Whole-genome and transcriptome analysis enhances precision cancer treatment options

Author

Pleasance, E., Bohm, A., Williamson, L.M., Nelson, J.M.T., Shen, Y., Bonakdar, M., Titmuss, E., Csizmok, V., Wee, K., Hosseinzadeh, S., Grisdale, C.J., Reisle, C., Taylor, G.A., Lewis, E., Jones, M.R., Bleile, D., Sadeghi, S., Zhang, W., Davies, A., Pellegrini, B., Wong, T., Bowlby, R., Chan, S.K., Mungall, K.L., Chuah, E., Mungall, A.J., Moore, R.A., Zhao, Y., Deol, B., Fisic, A., Fok, A., Regier, D.A., Weymann, D., Schaeffer, D.F., Young, S., Yip, S., Schrader, K., Levasseur, N., Taylor, S.K., Feng, X., Tinker, A., Savage, K.J., Chia, S., Gelmon, K., Sun, S., Lim, H., Renouf, D.J., Jones, S.J.M., Marra, M.A., and Laskin, J.

Published
2022
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2. Molecular composition of particulate matter emissions from dung and brushwood burning household cookstoves in Haryana, India

Author

Fleming, LT, Lin, P, Laskin, A, Laskin, J, Weltman, R, Edwards, RD, Arora, NK, Yadav, A, Meinardi, S, Blake, DR, Pillarisetti, A, Smith, KR, and Nizkorodov, SA

Subjects
Meteorology & Atmospheric Sciences, Atmospheric Sciences, Astronomical and Space Sciences
Abstract

Emissions of airborne particles from biomass burning are a significant source of black carbon (BC) and brown carbon (BrC) in rural areas of developing countries where biomass is the predominant energy source for cooking and heating. This study explores the molecular composition of organic aerosols from household cooking emissions with a focus on identifying fuel-specific compounds and BrC chromophores. Traditional meals were prepared by a local cook with dung and brushwood-fueled cookstoves in a village in Palwal district, Haryana, India. Cooking was done in a village kitchen while controlling for variables including stove type, fuel moisture, and meal. Fine particulate matter (PM2.5) emissions were collected on filters, and then analyzed via nanospray desorption electrospray ionization-high-resolution mass spectrometry (nano-DESI-HRMS) and high-performance liquid chromatography-photodiode array-high-resolution mass spectrometry (HPLC-PDA-HRMS) techniques. The nano-DESI-HRMS analysis provided an inventory of numerous compounds present in the particle phase. Although several compounds observed in this study have been previously characterized using gas chromatography methods a majority of the species in the nano-DESI spectra were newly observed biomass burning compounds. Both the stove (chulha or angithi) and the fuel (brushwood or dung) affected the composition of organic aerosols. The geometric mean of the PM2.5 emission factor and the observed molecular complexity increased in the following order: brushwood-chulha (7.3±1.8 g kg-1 dry fuel, 93 compounds), dung-chulha (21.1±4.2 g kg-1 dry fuel, 212 compounds), and dung-angithi (29.8±11.5 g kg-1 dry fuel, 262 compounds). The mass-normalized absorption coefficient (MACbulk) for the organic-solvent extractable material for brushwood PM2.5 was 3.7±1.5 and 1.9±0.8m2 g-1 at 360 and 405 nm, respectively, which was approximately a factor of two higher than that for dung PM2.5. The HPLC-PDA-HRMS analysis showed that, regardless of fuel type, the main chromophores were CxHyOz lignin fragments. The main chromophores accounting for the higher MACbulk values of brushwood PM2.5 were C8H10O3 (tentatively assigned to syringol), nitrophenols C8H9NO4, and C10H10O3 (tentatively assigned to methoxycinnamic acid).

Published
2018

3. Effect of relative humidity on the composition of secondary organic aerosol from the oxidation of toluene

Author

Hinks, ML, Montoya-Aguilera, J, Ellison, L, Lin, P, Laskin, A, Laskin, J, Shiraiwa, M, Dabdub, D, and Nizkorodov, SA

Subjects
Meteorology & Atmospheric Sciences, Astronomical and Space Sciences, Atmospheric Sciences
Abstract

The effect of relative humidity (RH) on the chemical composition of secondary organic aerosol (SOA) formed from low-NOx toluene oxidation in the absence of seed particles was investigated. SOA samples were prepared in an aerosol smog chamber at >2%RH and 75%RH, collected on Teflon filters, and analyzed with nanospray desorption electrospray ionization high-resolution mass spectrometry (nano-DESI-HRMS). Measurements revealed a significant reduction in the fraction of oligomers present in the SOA generated at 75%RH compared to SOA generated under dry conditions. In a separate set of experiments, the particle mass concentrations were measured with a scanning mobility particle sizer (SMPS) at RHs ranging from >2 to 90 %. It was found that the particle mass loading decreased by nearly an order of magnitude when RH increased from >2 to 75-90% for low-NOx toluene SOA. The volatility distributions of the SOA compounds, estimated from the distribution of molecular formulas using the "molecular corridor" approach, confirmed that low-NOx toluene SOA became more volatile on average under high-RH conditions. In contrast, the effect of RH on SOA mass loading was found to be much smaller for high-NOx toluene SOA. The observed increase in the oligomer fraction and particle mass loading under dry conditions were attributed to the enhancement of condensation reactions, which produce water and oligomers from smaller compounds in low-NOx toluene SOA. The reduction in the fraction of oligomeric compounds under humid conditions is predicted to partly counteract the previously observed enhancement in the toluene SOA yield driven by the aerosol liquid water chemistry in deliquesced inorganic seed particles.

Published
2018

4. Molecular Diversity of Sea Spray Aerosol Particles: Impact of Ocean Biology on Particle Composition and Hygroscopicity

Author

Cochran, RE, Laskina, O, Trueblood, JV, Estillore, AD, Morris, HS, Jayarathne, T, Sultana, CM, Lee, C, Lin, P, Laskin, J, Laskin, A, Dowling, JA, Qin, Z, Cappa, CD, Bertram, TH, Tivanski, AV, Stone, EA, Prather, KA, and Grassian, VH

Subjects
Macromolecular and Materials Chemistry
Abstract

The impact of sea spray aerosol (SSA) on climate depends on the size and chemical composition of individual particles that make up the total SSA ensemble. There remains a lack of understanding as to the composition of individual particles within the SSA ensemble and how it changes in response to dynamic ocean biology. Here, we characterize the classes of organic compounds as well as specific molecules within individual SSA particles. The diversity of molecules within the organic fraction was observed to vary between submicrometer- and supermicrometer-sized particles and included contributions from fatty acids, monosaccharides, polysaccharides, and siliceous material. Significant changes in this molecular diversity were observed to coincide with the rise and fall of phytoplankton and heterotrophic bacteria populations within the seawater. Furthermore, the water uptake of individual particles was affected, as learned from studying the hygroscopicity of model systems composed of representative mixtures of salts and organic compounds.

Published
2017

6. Osimertinib versus platinum–pemetrexed for patients with EGFR T790M advanced NSCLC and progression on a prior EGFR-tyrosine kinase inhibitor: AURA3 overall survival analysis

Author

Papadimitrakopoulou, V.A., Mok, T.S., Han, J.-Y., Ahn, M.-J., Delmonte, A., Ramalingam, S.S., Kim, S.W., Shepherd, F.A., Laskin, J., He, Y., Akamatsu, H., Theelen, W.S.M.E., Su, W.-C., John, T., Sebastian, M., Mann, H., Miranda, M., Laus, G., Rukazenkov, Y., and Wu, Y.-L.

Published
2020
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7. Complex refractive indices in the near-ultraviolet spectral region of biogenic secondary organic aerosol aged with ammonia

Author

Flores, JM, Washenfelder, RA, Adler, G, Lee, HJ, Segev, L, Laskin, J, Laskin, A, Nizkorodov, SA, Brown, SS, and Rudich, Y

Subjects
Climate Action, Aerosols, Ammonia, Molecular Structure, Spectrophotometry, Ultraviolet, Chemical Physics
Abstract

Atmospheric absorption by brown carbon aerosol may play an important role in global radiative forcing. Brown carbon arises from both primary and secondary sources, but the mechanisms and reactions of the latter are highly uncertain. One proposed mechanism is the reaction of ammonia or amino acids with carbonyl products in secondary organic aerosol (SOA). We generated SOA in situ by reacting biogenic alkenes (α-pinene, limonene, and α-humulene) with excess ozone, humidifying the resulting aerosol, and reacting the humidified aerosol with gaseous ammonia. We determined the complex refractive indices (RI) in the 360-420 nm range for these aerosols using broadband cavity enhanced spectroscopy (BBCES). The average real part (n) of the measured spectral range of the NH3-aged α-pinene SOA increased from n = 1.50 (±0.01) for the unreacted SOA to n = 1.57 (±0.01) after 1.5 h of exposure to 1.9 ppm NH3, whereas the imaginary component (k) remained below k < 0.001((+0.002)(-0.001)). For the limonene and α-humulene SOA the real part did not change significantly, and we observed a small change in the imaginary component of the RI. The imaginary component increased from k = 0.000 to an average k = 0.029 (±0.021) for α-humulene SOA, and from k < 0.001((+0.002)(-0.001)) to an average k = 0.032 (±0.019) for limonene SOA after 1.5 h of exposure to 1.3 and 1.9 ppm of NH3, respectively. Collected filter samples of the aged and unreacted α-pinene SOA and limonene SOA were analyzed off-line by nanospray desorption electrospray ionization high resolution mass spectrometry (nano-DESI/HR-MS), and in situ using a Time-of-Flight Aerosol Mass Spectrometer (ToF-AMS), confirming that the SOA reacted and that various nitrogen-containing reaction products formed. If we assume that NH3 aging reactions scale linearly with time and concentration, which will not necessarily be the case in the atmosphere, then a 1.5 h reaction with 1 ppm NH3 in the laboratory is equivalent to 24 h reaction with 63 ppbv NH3, indicating that the observed aerosol absorption will be limited to atmospheric regions with high NH3 concentrations.

Published
2014

8. Effect of humidity on the composition of isoprene photooxidation secondary organic aerosol

Author

Nguyen, T. B, Roach, P. J, Laskin, J., Laskin, A., and Nizkorodov, S. A

Subjects
h-atom transfer, mass-spectrometry, particulate matter, heterogeneous reactions, atmospheric chemistry, chemical-composition, alpha-pinene, hygroscopic properties, accretion reactions, alkoxy radicals
Abstract

The effect of relative humidity (RH) on the composition and concentrations of gas-phase products and secondary organic aerosol (SOA) generated from the photooxidation of isoprene under high-NOx conditions was investigated. Experiments were performed with hydrogen peroxide as the OH precursor and in the absence of seed aerosol. The relative yields of most gas-phase products were the same regardless of initial water vapor concentration with exception of hydroxyacetone and glycolaldehyde, which were considerably affected by RH. A significant change was observed in the SOA composition, with many unique condensed-phase products formed under humid (90% RH) vs. dry (< 2% RH) conditions, without any detectable effect on the rate and extent of the SOA mass growth. There is a 40% reduction in the number and relative abundance of distinct particle-phase nitrogen-containing organic compounds (NOC) detected by high resolution mass spectrometry. The suppression of condensation reactions, which produce water as a product, is the most important chemical effect of the increased RH. For example, the total signal from oligomeric esters of 2-methylglyceric acid was reduced by about 60% under humid conditions and the maximum oligomer chain lengths were reduced by 7-11 carbons. Oligomers formed by addition mechanisms, without direct involvement of water, also decreased at elevated RH but to a much smaller extent. The observed reduction in the extent of condensation-type oligomerization at high RH may have substantial impact on the phase characteristics and hygroscopicity of the isoprene aerosol. The reduction in the amount of organic nitrates in the particle phase has implications for understanding the budget of NOC compounds.

Published
2011

11. Immune Activation following Irbesartan Treatment in a Colorectal Cancer Patient: A Case Study

Author

Titmuss, E., primary, Milne, K., additional, Jones, M. R., additional, Ng, T., additional, Topham, J. T., additional, Brown, S. D., additional, Schaeffer, D. F., additional, Kalloger, S., additional, Wilson, D., additional, Corbett, R. D., additional, Williamson, L. M., additional, Mungall, K., additional, Mungall, A. J., additional, Holt, R. A., additional, Nelson, B. H., additional, Jones, S. J. M., additional, Laskin, J., additional, Lim, H. J., additional, and Marra, M. A., additional

Published
2023
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13. LBA4 Preliminary safety and efficacy of adagrasib with pembrolizumab in treatment-naïve patients with advanced non-small cell lung cancer (NSCLC) harboring a KRASG12C mutation

Author

Jänne, P.A., primary, Smit, E.F., additional, de Marinis, F., additional, Laskin, J., additional, Gomez, M. Domine, additional, Gadgeel, S., additional, Garassino, M.C., additional, Lu, S., additional, Spira, A.S., additional, Kang, V., additional, Roshan, S., additional, Yan, X., additional, and Felip, E., additional

Published
2022
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16. EP04.02-004 The Patient Impact of Liquid Biopsy - Health-Related Quality of Life in Patients Undergoing Liquid Biopsy for Advanced Non-Small Cell Lung Cancer

Author

Corke, L., primary, Laskin, J., additional, Agulnik, J., additional, Laurie, S., additional, Hao, D., additional, Juergens, R., additional, Fernandes, R., additional, Le, L., additional, Law, J., additional, Ezeife, D., additional, Shookoohi, A., additional, Kasymjanova, G., additional, Kelly, S., additional, Nadon, T., additional, Lanman, R., additional, Kiedrowski, L., additional, and Leighl, N., additional

Published
2022
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17. EP08.02-108 Osimertinib Long-Term Tolerability in Patients with EGFRm NSCLC Enrolled in the AURA Program or FLAURA Study

Author

Garassino, M.C., primary, He, Y., additional, Ahn, M.-J., additional, Orlov, S., additional, Potter, V., additional, Kato, T., additional, Laskin, J., additional, Voon, P.J., additional, Reungwetwattana, T., additional, Ramalingam, S., additional, Wu, Y.-L., additional, Albayaty, M., additional, Cross, S., additional, Huang, X., additional, Kulkarni, D., additional, and Cho, B.C., additional

Published
2022
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20. OA16.02 The Economic Value of Liquid Biopsy for Genomic Profiling in Advanced Non-Small Cell Lung Cancer

Author

Ezeife, D., primary, Spackman, E., additional, Juergens, R., additional, Laskin, J., additional, Agulnik, J., additional, Hao, D., additional, Laurie, S., additional, Law, J., additional, Le, L., additional, Kiedrowski, L., additional, Melosky, B., additional, Shepherd, F.A., additional, Cohen, V., additional, Wheatley-Price, P., additional, Vandermeer, R., additional, Li, J., additional, Fernandes, R., additional, Shokoohi, A., additional, Lanman, R., additional, and Leighl, N., additional

Published
2021
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27. P89.03 Demonstrating VALUE of Liquid Biopsy for Lung Cancer in a Public Healthcare System

Author

Hao, D., primary, Laskin, J., additional, Laurie, S., additional, Agulnik, J., additional, Juergens, R., additional, Ezeife, D., additional, Law, J., additional, Le, L., additional, Kiedrowski, L., additional, Melosky, B., additional, Shepherd, F., additional, Cohen, V., additional, Vandermeer, R., additional, Shokoohi, A., additional, Li, J., additional, Fernandes, R., additional, Lanman, R., additional, and Leighl, N., additional

Published
2021
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30. 1195P The value of detecting resistance through liquid biopsy

Author

Laurie, S., primary, Agulnik, J., additional, Hao, D., additional, Juergens, R., additional, Ezeife, D., additional, Law, J., additional, Le, L., additional, Kiedrowski, L., additional, Shepherd, F., additional, Cohen, V., additional, Melosky, B., additional, Vandermeer, R., additional, Wheatley-Price, P., additional, Lanman, R.B., additional, Leighl, N., additional, and Laskin, J., additional

Published
2020
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31. Overall survival (OS) from the AURA3 phase III study: Osimertinib vs platinum-pemetrexed (plt-pem) in patients (pts) with EGFR T790M advanced non-small cell lung cancer (NSCLC) and progression on a prior EGFR-tyrosine kinase inhibitor (TKI)

Author

Wu, Y.-L., primary, Mok, T.S.K., additional, Han, J.-Y., additional, Ahn, M.-J., additional, Delmonte, A., additional, Ramalingam, S.S., additional, Kim, S.-W., additional, Shepherd, F.A., additional, Laskin, J., additional, He, Y., additional, Akamatsu, H., additional, Theelen, W.S.M.E., additional, Su, W.-C., additional, John, T., additional, Sebastian, M., additional, Mann, H., additional, Miranda, M., additional, Laus, G., additional, Rukazenkov, Y., additional, and Papadimitrakopoulou, V., additional

Published
2019
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35. Canadian Consensus: Oligoprogressive, Pseudoprogressive, and Oligometastatic Non-Small-Cell Lung Cancer

Author

Laurie, S.A., primary, Banerji, S., additional, Blais, N., additional, Brule, S., additional, Cheema, P.K., additional, Cheung, P., additional, Daaboul, N., additional, Hao, D., additional, Hirsh, V., additional, Juergens, R., additional, Laskin, J., additional, Leighl, N., additional, MacRae, R., additional, Nicholas, G., additional, Roberge, D., additional, Rothenstein, J., additional, Stewart, D.J., additional, and Tsao, M.S., additional

Published
2019
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36. FUS-NFATc2 sarcoma of bone, a novel molecular entity with aggressive behavior: Clinical and molecular pathology findings of two cases

Author

Lacambra, M.D., primary, Loong, H., additional, To, K.F., additional, Feng, X., additional, Taylor, G., additional, Pleasance, E., additional, Laskin, J., additional, Marra, M., additional, Griffith, J., additional, Yeung, H.Y.M., additional, Wong, K.-C., additional, Chow, C., additional, Kumta, S., additional, Ng, W.H.A., additional, Tse, T., additional, Tong, C., additional, and Ng, T., additional

Published
2018
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37. ASTRIS real world study of osimertinib in patients (pts) with EGFR T790M NSCLC: Efficacy analysis by tissue or plasma T790M test

Author

Freitas, H.C., primary, Park, K., additional, Kim, D.-W., additional, Tiseo, M., additional, Hochmair, M.J., additional, Chang, G.-C., additional, Shi, Y.-K., additional, Moran, T., additional, Chen, Y., additional, Laskin, J., additional, Solomon, B., additional, Miranda, M., additional, Rigas, J., additional, Cheema, P.K., additional, and Kim, S.-W., additional

Published
2018
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38. Personalized oncogenomics in the management of gastrointestinal carcinomas&mdash

Author

Sheffield, B.S., Tessier-Cloutier, B., Li-Chang, H., Shen, Y., Pleasance, E., Kasaian, K., Li, Y., Jones, S.J.M., Lim, H.J., Renouf, D.J., Huntsman, D.G., Yip, S., Laskin, J., Marra, M., and Schaeffer, D.F.

Subjects
Oncogenomics, colonic adenocarcinoma, appendiceal adenocarcinoma, genomics, personalized medicine, bevacizumab, cholangiocarcinoma, targeted therapy, digestive system diseases
Abstract

Gastrointestinal carcinomas are genomically complex cancers that are lethal in the metastatic setting. Whole-genome and transcriptome sequencing allow for the simultaneous characterization of multiple oncogenic pathways. We report 3 cases of metastatic gastrointestinal carcinoma in patients enrolled in the Personalized Onco-Genomics program at the BC Cancer Agency. Real-time genomic profiling was combined with clinical expertise to diagnose a carcinoma of unknown primary, to explore treatment response to bevacizumab in a colorectal cancer, and to characterize an appendiceal adenocarcinoma. In the first case, genomic profiling revealed an IDH1 somatic mutation, supporting the diagnosis of cholangiocarcinoma in a malignancy of unknown origin, and further guided therapy by identifying epidermal growth factor receptor amplification. In the second case, a BRAF V600E mutation and wild-type KRAS profile justified the use of targeted therapies to treat a colonic adenocarcinoma. The third case was an appendiceal adenocarcinoma defined by a p53 inactivation, Ras/raf/mek, Akt/mtor, Wnt, and notch pathway activation, and overexpression of ret, erbb2 (her2), erbb3, met, and cell cycle regulators. We show that whole-genome and transcriptome sequencing can be achieved within clinically effective timelines, yielding clinically useful and actionable information.

Published
2016
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45. OA 10.01 Detection of EGFR mutations from plasma ctDNA in the osimertinib Phase III trial (AURA3): comparison of three plasma assays

Author

Ahn, M., primary, Han, J., additional, Tsai, C., additional, Delmonte, A., additional, Hsia, T., additional, Laskin, J., additional, Kim, S., additional, He, Y., additional, Hida, T., additional, Maemondo, M., additional, Kato, T., additional, Jenkins, S., additional, Markovets, A., additional, Thress, K., additional, and Mok, T., additional

Published
2017
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47. P3.01-019 Canadian Multicenter Validation Study of Plasma Circulating Tumor DNA for Epidermal Growth Factor (EGFR) T790M Testing

Author

Tsao, M., primary, Zhang, T., additional, Cheema, P., additional, Laskin, J., additional, Karsan, A., additional, Barnes, T., additional, Liu, G., additional, Owen, S., additional, Rothenstein, J., additional, Burkes, R., additional, Iqbal, M., additional, Spatz, A., additional, Izevbaye, I., additional, Kempen, L., additional, Kamel-Reid, S., additional, and Leighl, N., additional

Published
2017
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48. P3.01-062 The Perceived Value of Avoiding Biopsy: Patients' Willingness to Pay for Circulating Tumor DNA T790M Testing

Author

Barnes, T., primary, Laskin, J., additional, Cheema, P., additional, Liu, G., additional, Iqbal, M., additional, Rothenstein, J., additional, Burkes, R., additional, Owen, S., additional, Laurence, D., additional, Carvalhana, I., additional, Markin, L., additional, Wong, L., additional, Perera-Low, N., additional, Sawczak, M., additional, Tsao, M., additional, and Leighl, N., additional

Published
2017
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