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Human adenovirus (HAdV) infections can cause a range of symptoms but most commonly result in respiratory illnesses (1). Most HAdV infections are not clinically severe; however, more serious illness can [...]

As of August 2022, clusters of acute severe hepatitis of unknown aetiology in children have been reported from 35 countries, including the USA1,2. Previous studies have found human adenoviruses (HAdVs) in the blood from patients in Europe and the USA3-7, although it is unclear whether this virus is causative. Here we used PCR testing, viral enrichment-based sequencing and agnostic metagenomic sequencing to analyse samples from 16 HAdV-positive cases from 1 October 2021 to 22 May 2022, in parallel with 113 controls. In blood from 14 cases, adeno-associated virus type 2 (AAV2) sequences were detected in 93% (13 of 14), compared to 4 (3.5%) of 113 controls (P

As of August 10, 2022, the SARS-CoV-2 pandemic had claimed >6.4 million human lives globally, >1 million in the United States, and >70,000 in New York state (1). Virus evolution [...]

The emergence of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant B.1.1.7 (Alpha) in the United Kingdom in late 2020 raised alarm worldwide and prompted major reassessment of [...]

The recently emerged Omicron variant of severe respiratory syndrome coronavirus 2 (SARS-CoV-2) (1) is highly transmissible and partially immune evasive (2). Omicron contributes to the recent surges in coronavirus disease [...]

Human adenovirus genome (HAdV) type 7d (HAdV-7d) was first detected in the United States in December 2013 in Oregon, in association with acute respiratory disease (ARD) requiring hospitalization (1). In [...]

Human adenovirus type 4 (HAdV-4), the only human adenovirus classified within species E, was first identified in the early 1950s in association with military outbreaks of febrile respiratory illness and [...]

Human adenoviruses (HAdVs) contain linear, double-stranded DNA with an average genomic length of 35 kbp. The 51 serotypes identified by seroneutralization and >70 genotypes that have been described by computational [...]

Human adenovirus type 4 (HAdV-4) is most commonly isolated in military settings. We conducted detailed molecular characterization on 36 HAdV-4 isolates recovered from civilian adults with acute respiratory disease (ARD) in the northeastern United States during 2011-2015. Specimens came from college students, residents of long-term care facilities or nursing homes, a cancer patient, and young adults without co-morbidities. HAdV-4 genome types 4a1 and 4a2, the variants most frequently detected among US military recruits in basic training before the restoration of vaccination protocols, were isolated in most cases. Two novel a-like variants were recovered from students enrolled at a college in Tompkins County, New York, USA, and a prototype-like variant distinguishable from the vaccine strain was isolated from an 18-year-old woman visiting a physician's office in Ulster County, New York, USA, with symptoms of influenza-like illness. Our data suggest that HAdV-4 might be an underestimated causative agent of ARD among civilian adults. [ABSTRACT FROM AUTHOR]

Human adenovirus type 4 (HAdV-4) is most commonly isolated in military settings. We conducted detailed molecular characterization on 36 HAdV-4 isolates recovered from civilian adults with acute respiratory disease (ARD) in the northeastern United States during 2011-2015. Specimens came from college students, residents of long-term care facilities or nursing homes, a cancer patient, and young adults without co-morbidities. HAdV-4 genome types 4a1 and 4a2, the variants most frequently detected among US military recruits in basic training before the restoration of vaccination protocols, were isolated in most cases. Two novel a-like variants were recovered from students enrolled at a college in Tompkins County, New York, USA, and a prototype-like variant distinguishable from the vaccine strain was isolated from an 18-year-old woman visiting a physician's office in Ulster County, New York, USA, with symptoms of influenza-like illness. Our data suggest that HAdV-4 might be an underestimated causative agent of ARD among civilian adults. [ABSTRACT FROM AUTHOR]

During October-November 2021, clinicians at a children's hospital in Alabama identified five pediatric patients with severe hepatitis and adenovirus viremia upon admission. In November 2021, hospital clinicians, the Alabama Department of Public Health, the Jefferson County Department of Health, and CDC began an investigation. This activity was reviewed by CDC and conducted consistent with applicable federal law and CDC policy., Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. William Britt reports consulting fees from Hookipa Pharma and stocks from Kroger Care, First Energy Corporation, MDU Resources Group, and PG&E Corporation. Elizabeth A. Moulton serves as a coinvestigator for Pfizer SARS-CoV-2 vaccine trials in healthy and immunocompromised pediatric patients with payment made to her institution. Kirsten St. George reports receipt of research support for her institution through equipment and materials from Thermo Fisher, and royalties from ZeptoMetrix Corporation paid to her institution. No other potential conflicts of interest were disclosed.