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1. Temporal Improvements in COVID-19 Outcomes for Hospitalized Adults: A Post Hoc Observational Study of Remdesivir Group Participants in the Adaptive COVID-19 Treatment Trial

Author

Potter, Gail E, Bonnett, Tyler, Rubenstein, Kevin, Lindholm, David A, Rapaka, Rekha R, Doernberg, Sarah B, Lye, David C, Mularski, Richard A, Hynes, Noreen A, Kline, Susan, Paules, Catharine I, Wolfe, Cameron R, Frank, Maria G, Rouphael, Nadine G, Deye, Gregory A, Sweeney, Daniel A, Colombo, Rhonda E, Davey, Richard T, Mehta, Aneesh K, Whitaker, Jennifer A, Castro, Jose G, Amin, Alpesh N, Colombo, Christopher J, Levine, Corri B, Jain, Mamta K, Maves, Ryan C, Marconi, Vincent C, Grossberg, Robert, Hozayen, Sameh, Burgess, Timothy H, Atmar, Robert L, Ganesan, Anuradha, Gomez, Carlos A, Benson, Constance A, de Castilla, Diego Lopez, Ahuja, Neera, George, Sarah L, Nayak, Seema U, Cohen, Stuart H, Lalani, Tahaniyat, Short, William R, Erdmann, Nathaniel, Tomashek, Kay M, and Tebas, Pablo

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Clinical Research, Rehabilitation, Complementary and Integrative Health, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Good Health and Well Being, Adult, Humans, Antiviral Agents, Clinical Trials, Phase III as Topic, Dexamethasone, Double-Blind Method, Randomized Controlled Trials as Topic, Treatment Outcome, COVID-19 Drug Treatment, Medical and Health Sciences, General & Internal Medicine, Clinical sciences
Abstract

BackgroundThe COVID-19 standard of care (SOC) evolved rapidly during 2020 and 2021, but its cumulative effect over time is unclear.ObjectiveTo evaluate whether recovery and mortality improved as SOC evolved, using data from ACTT (Adaptive COVID-19 Treatment Trial).DesignACTT is a series of phase 3, randomized, double-blind, placebo-controlled trials that evaluated COVID-19 therapeutics from February 2020 through May 2021. ACTT-1 compared remdesivir plus SOC to placebo plus SOC, and in ACTT-2 and ACTT-3, remdesivir plus SOC was the control group. This post hoc analysis compared recovery and mortality between these comparable sequential cohorts of patients who received remdesivir plus SOC, adjusting for baseline characteristics with propensity score weighting. The analysis was repeated for participants in ACTT-3 and ACTT-4 who received remdesivir plus dexamethasone plus SOC. Trends in SOC that could explain outcome improvements were analyzed. (ClinicalTrials.gov: NCT04280705 [ACTT-1], NCT04401579 [ACTT-2], NCT04492475 [ACTT-3], and NCT04640168 [ACTT-4]).Setting94 hospitals in 10 countries (86% U.S. participants).ParticipantsAdults hospitalized with COVID-19.InterventionSOC.Measurements28-day mortality and recovery.ResultsAlthough outcomes were better in ACTT-2 than in ACTT-1, adjusted hazard ratios (HRs) were close to 1 (HR for recovery, 1.04 [95% CI, 0.92 to 1.17]; HR for mortality, 0.90 [CI, 0.56 to 1.40]). Comparable patients were less likely to be intubated in ACTT-2 than in ACTT-1 (odds ratio, 0.75 [CI, 0.53 to 0.97]), and hydroxychloroquine use decreased. Outcomes improved from ACTT-2 to ACTT-3 (HR for recovery, 1.43 [CI, 1.24 to 1.64]; HR for mortality, 0.45 [CI, 0.21 to 0.97]). Potential explanatory factors (SOC trends, case surges, and variant trends) were similar between ACTT-2 and ACTT-3, except for increased dexamethasone use (11% to 77%). Outcomes were similar in ACTT-3 and ACTT-4. Antibiotic use decreased gradually across all stages.LimitationUnmeasured confounding.ConclusionChanges in patient composition explained improved outcomes from ACTT-1 to ACTT-2 but not from ACTT-2 to ACTT-3, suggesting improved SOC. These results support excluding nonconcurrent controls from analysis of platform trials in rapidly changing therapeutic areas.Primary funding sourceNational Institute of Allergy and Infectious Diseases.

Published
2022

2. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials

Author

Hermine, Olivier, Mariette, Xavier, Ravaud, Philippe, Bureau, Serge, Dougados, Maxime, Resche-Rigon, Matthieu, Tharaux, Pierre-Louis, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Porcher, Raphaël, Pourchet-Martinez, Valerie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Raked, Nabil, Mameri, Lakhdar, Montlahuc, Claire, Biard, Lucie, Alary, St.phanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Charreteur, Robin, Dupre, Céline, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madelaine, Claire, D'Ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, Laurent, Harrois, Anatole, Figueiredo, Samy, Duranteau, Jacques, Anguel, Nadia, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Teboul, Jean-Louis, Durand, Philippe, Tissieres, Pierre, Jevnikar, Mitja, Montani, David, Pavy, Stephan, Nocturne, Gaétane, Bitoun, Samuel, Noel, Nicolas, Lambotte, Olivier, Escaut, Lelia, Jauréguiberry, Stephane, Baudry, Elodie, Verny, Christiane, Lefevre, Edouard, Zaidan, Mohamad, Molinari, Domitille, Leprun, Gaël, Fourreau, Alain, Cylly, Laurent, Grimaldi, Lamiae, Virlouvet, Myriam, Meftali, Ramdane, Fabre, Soléne, Licois, Marion, Mamoune, Asmaa, Boudali, Yacine, Le Tiec, Clotilde, Verstuyft, Céline, Roques, Anne-Marie, Georgin-Lavialle, Sophie, Senet, Patricia, Pialoux, Gilles, Soria, Angele, Parrot, Antoine, François, Helene, Rozensztajn, Nathalie, Blin, Emmanuelle, Choinier, Pascaline, Camuset, Juliette, Rech, Jean-Simon, Canellas, Antony, Rolland-Debord, Camille, Lemarié, Nadege, Belaube, Nicolas, Nadal, Marine, Siguier, Martin, Petit-Hoang, Camille, Chas, Julie, Drouet, Elodie, Lemoine, Matthieu, Phibel, Audrey, Aunay, Lucie, Bertrand, Eliane, Ravato, Sylviane, Vayssettes, Marie, Adda, Anne, Wilpotte, Celine, Thibaut, Pélagie, Fillon, Julie, Debrix, Isabelle, Fellahi, Soraya, Bastard, Jean-Philippe, Lefévre, Guillaume, Gottenberg, Jacques-Eric, Hansmann, Yves, Blanc, Frédéric, Ohlmann-Caillard, Sophie, Castelain, Vincent, Chatelus, Emmanuel, Chatron, Eva, Collange, Olivier, Danion, François, De Blay, Frédéric, Diemunsch, Pierre, Diemunsch, Sophie, Felten, Renaud, Goichot, Bernard, Greigert, Valentin, Guffroy, Aurelien, Heger, Bob, Kaeuffer, Charlotte, Kassegne, Loic, Korganow, Anne Sophie, Le Borgne, Pierrick, Lefebvre, Nicolas, Mertes, Paul-Michel, Noll, Eric, Oberlin, Mathieu, Poindron, Vincent, Pottecher, Julien, Ruch, Yvon, Weill, François, Meyer, Nicolas, Andres, Emmanuel, Demonsant, Eric, Tayebi, Hakim, Nisand, Gabriel, Brin, Stéphane, Sublon, Cédric, Becker, Guillaume, Hutt, Anne, Martin, Tristan, Bayer, Sophie, Metzger, Catherine, Mekinian, Arsene, Abisror, Noémie, Adedjouma, Amir, Bollens, Diane, Bonneton, Marion, Bourcicaux, Nathalie, Bourrier, Anne, Thibault Chiarabiani, Maria Chauchard, Chopin, Doroth.e, Cohen, Jonathan, Devred, Ines, Donadille, Bruno, Fain, Olivier, Hariri, Geoffrey, Jachiet, Vincent, Ingliz, Patrick, Garnier, Marc, Gatfosse, Marc, Ghrenassia, Etienne, Gobert, Delphine, Krause le Garrec, Jessica, Landman, Cecilia, Lavillegrand, Jean Remy, Lefebvre, Benedicte, Mahevas, Thibault, Mazerand, Sandie, Meynard, Jean Luc, Morgand, Marjolaine, Ouaz.ne, Zineb, Pacanowski, Jerome, Riviere, S.bastien, Seksik, Philippe, Sokol, Harry, Soliman, Heithem, Valin, Nadia, Urbina, Thomas, McAvoy, Chloé, Miranda, Maria Pereira, Aratus, Gladys, Berard, Laurence, Simon, Tabassome, Nguyen, Anne Daguenel, Girault, Elise, Mayala-Kanda, Cl.mentine, Antignac, Marie, Leplay, Céline, Arlet, Jean-Benoit, Diehl, Jean-Luc, Bellenfant, Florence, Blanchard, Anne, Buffet, Alexandre, Cholley, Bernard, Fayol, Antoine, Flamarion, Edouard, Godier, Anne, Gorget, Thomas, Hamada, Sophie-Rym, Hauw-Berlemont, Caroline, Hulot, Jean-Sébastien, Lebeaux, David, Livrozet, Marine, Michon, Adrien, Neuschwander, Arthur, Pennet, Marie-Aude, Planquette, Benjamin, Ranque, Brigitte, Sanchez, Olivier, Volle, Geoffroy, Briois, Sandrine, Cornic, Mathias, Elisee, Virginie, Denis, Jesuthasan, Djadi-Prat, Juliette, Jouany, Pauline, Junquera, Ramon, Henriques, Mickael, Kebir, Amina, Lehir, Isabelle, Meunier, Jeanne, Patin, Florence, Paquet, Val.rie, Tréhan, Anne, Vigna, Véronique, Sabatier, Brigitte, Bergerot, Damien, Jouve, Charléne, Knosp, Camille, Lenoir, Olivia, Mahtal, Nassim, Resmini, Léa, Lescure, Xavier, Ghosn, Jade, Bachelard, Antoine, Rachline, Anne, Isernia, Valentina, Bao-chau, Phung, Vallois, Dorothée, Sautereau, Aurelie, Neukrich, Catherine, Dossier, Antoine, Borie, Raphaël, Crestani, Bruno, Ducrocq, Gregory, Steg, Philippe Gabriel, Dieude, Philippe, Papo, Thomas, Marcault, Estelle, Chaudhry, Marhaba, Da Silveira, Charléne, Metois, Annabelle, Mahenni, Ismahan, Meziani, Meriam, Nilusmas, Cyndie, Le Gac, Sylvie, Ndiaye, Awa, Louni, Fran.oise, Chansombat, Malikhone, Julia, Zelie, Chalal, Solaya, Chalal, Lynda, Kramer, Laura, Le Grand, Jeniffer, Ouifiya, Kafif, Piquard, Valentine, Tubiana, Sarah, Nguyen, Yann, Honsel, Vasco, Weiss, Emmanuel, Codorniu, Anais, Zarrouk, Virginie, de Lastours, Victoire, Uzzan, Matthieu, Gamany, Naura, Claveirole, Agathe, Navid, Alexandre, Fouque, Tiffanie, Cohen, Yonathan, Lupo, Maya, Gilles, Constance, Rahli, Roza, Louis, Zeina, Boutboul, David, Galicier, Lionel, Amara, Yaël, Archer, Gabrielle, Benattia, Amira, Bergeron, Anne, Bondeelle, Louise, de Castro, Nathalie, Clément, Melissa, Darmon, Michaël, Denis, Blandine, Dupin, Clairelyne, Feredj, Elsa, Feyeux, Delphine, Joseph, Adrien, Lenglin, Etienne, Le Guen, Pierre, Liégeon, Geoffroy, Lorillon, Gwenaël, Mabrouki, Asma, Mariotte, Eric, Martin de Frémont, Grégoire, Mirouse, Adrien, Molina, Jean-Michel, Peffault de Latour, Régis, Oksenhendler, Eric, Saussereau, Julien, Tazi, Abdellatif, Tudesq, Jean-Jacques, Zafrani, Lara, Brindele, Isabelle, Bugnet, Emmanuelle, Lebras, Karine Celli, Chabert, Julien, Djaghout, Lamia, Fauvaux, Catherine, Jegu, Anne Lise, Kozakiewicz, Ewa, Meunier, Martine, Tremorin, Marie-Thérèse, Davoine, Claire, Madelaine, Isabelle, Caillat-Zucman, Sophie, Delaugerre, Constance, Morin, Florence, Sène, Damien, Burlacu, Ruxandra, Chousterman, Benjamin, Mégarbanne, Bruno, Richette, Pascal, Riveline, Jean-Pierre, Frazier, Aline, Vicaut, Eric, Berton, Laure, Hadjam, Tassadit, Vazquez-Ibarra, Miguel Alejandro, Jourdaine, Clément, Tran, Olivia, Jouis, Véronique, Jacob, Aude, Smati, Julie, Renaud, Stéphane, Pernin, Claire, Suarez, Lydia, Semerano, Luca, Abad, Sébastien, nainous, Ruben B., Bonnet, Nicolas, Comparon, Celine, Cohen, Yves, Cordel, Hugues, Dhote, Robin, Dournon, Nathalie, Duchemann, Boris, Ebstein, Nathan, Gille, Thomas, Giroux-Leprieur, Benedicte, Goupil de Bouille, Jeanne, Nunes, Hilario, Oziel, Johanna, Roulot, Dominique, Sese, Lucile, ClaireTantet, Uzunhan, Yurdagul, Bloch-Queyrat, Coralie, Levy, Vincent, Messani, Fadhila, Rahaoui, Mohammed, Petit, Myléne, Brahmi, Sabrina, Rathoin, Vanessa, Rigal, Marthe, Costedoat-Chalumeau, Nathalie, Luong, Liem Binh, Hamou, Zakaria Ait, Benghanem, Sarah, Blanche, Philippe, Carlier, Nicolas, Chaigne, Benjamin, Gauzit, Remy, Joumaa, Hassan, Jozwiak, Mathieu, Lachétre, Marie, Lafoeste, Hélène, Launay, Odie, Legendre, Paul, Marey, Jonathan, Morbieu, Caroline, Palmieri, Lola-Jade, Szwebel, Tali-Anne, Abdoul, Hendy, Bruneau, Alexandra, Beclin-Clabaux, Audrey, Larrieu, Charly, Montanari, Pierre, Dufour, Eric, Clarke, Ada, Le Bourlout, Catherine, Marin, Nathalie, Menage, Nathalie, Saleh-Mghir, Samira, Cisse, Mamadou Salif, Cheref, Kahina, Guerin, Corinne, Zerbit, Jérémie, Michel, Marc, Gallien, Sébastien, Crickx, Etienne, Le Vavasseur, Benjamin, Kempf, Emmanuelle, Jaffal, Karim, Vindrios, William, Oniszczuk, Julie, Guillaud, Constance, Lim, Pascal, Fois, Elena, Melica, Giovanna, Matignon, Marie, Jalabert, Maud, Lelièvre, Jean-Daniel, Schmitz, David, Bourhis, Marion, Belazouz, Sylia, Languille, Laetitia, Boucle, Caroline, Cita, Nelly, Didier, Agnés, Froura, Fahem, Ledudal, Katia, Sadaoui, Thiziri, Thiemele, Alaki, Le Febvre De Bailly, Delphine, Verlinde, Muriel Carvhalo, Mayaux, Julien, Cacoub, Patrice, Saadoun, David, Vautier, Mathieu, Bugaut, Héléne, Benveniste, Olivier, Allenbach, Yves, Leroux, Gaëlle, Rigolet, Aude, Guillaume-Jugnot, Perrine, Domont, Fanny, Desbois, Anne Claire, Comarmond, Chloé, Champtiaux, Nicolas, Toquet, Segolene, Ghembaza, Amine, Vieira, Matheus, Maalouf, Georgina, Boleto, Goncalo, Ferfar, Yasmina, Corvol, Jean-Christophe, Louapre, C.line, Sambin, Sara, Mariani, Louise-Laure, Karachi, Carine, Tubach, Florence, Estellat, Candice, Gimeno, Linda, Martin, Karine, Bah, Aicha, Keo, Vixra, Ouamri, Sabrine, Messaoudi, Yasmine, Yelles, Nessima, Faye, Pierre, Cavelot, Sebastien, Larcheveque, Cecile, Annonay, Laurence, Benhida, Jaouad, Zahrate-Ghoul, Aida, Hammal, Soumeya, Belilita, Ridha, Charbonnier, Fanny, Aguilar, Claire, Alby-Laurent, Fanny, Burger, Carole, Campos-Vega, Clara, Chavarot, Nathalie, Fournier, Benjamin, Rouzaud, Claire, Vimpére, Damien, Elie, Caroline, Bakouboula, Prissile, Choupeaux, Laure, Granville, Sophie, Issorat, Elodie, Broissand, Christine, Alyanakian, Marie-Alexandra, Geri, Guillaume, Derridj, Nawal, Sguiouar, Naima, Meddah, Hakim, Djadel, Mourad, Chambrin-Lauvray, Héléne, Duclos-vallée, Jean-Charles, Saliba, Faouzi, Sacleux, Sophie-Caroline, Kounis, Ilias, Tamazirt, Sonia, Rudant, Eric, Michot, Jean-Marie, Stoclin, Annabelle, Colomba, Emeline, Pommeret, Fanny, Willekens, Christophe, Da Silva, Rosa, Dejean, Valérie, Mekid, Yasmina, Ben-Mabrouk, Ines, Netzer, Florence, Pradon, Caroline, Drouard, Laurence, Camara-Clayette, Valérie, Morel, Alexandre, Garcia, Gilles, Mohebbi, Abolfazl, Berbour, Férial, Dehais, Mélanie, Pouliquen, Anne-Lise, Klasen, Alison, Soyez-Herkert, Loren, London, Jonathan, Keroumi, Younes, Guillot, Emmanuelle, Grailles, Guillaume, El amine, Younes, Defrancq, Fanny, Fodil, Hanane, Bouras, Chaouki, Dautel, Dominique, Gambier, Nicolas, Dieye, Thierno, Bienvenu, Boris, Lancon, Victor, Lecomte, Laurence, Beziriganyan, Kristina, Asselate, Belkacem, Allanic, Laure, Kiouris, Elena, Legros, Marie-Héléne, Lemagner, Christine, Martel, Pascal, Provitolo, Vincent, Ackermann, Félix, Le Marchand, Mathilde, Chan Hew Wai, Aurélie, Fremont, Dimitri, Coupez, Elisabeth, Adda, Mireille, Duée, Frédéric, Bernard, Lise, Gros, Antoine, Henry, Estelle, Courtin, Claire, Pattyn, Anne, Guinot, Pierre-Grégoire, Bardou, Marc, Maurer, Agnes, Jambon, Julie, Cransac, Amélie, Pernot, Corinne, Mourvillier, Bruno, Marquis, Eric, Benoit, Philippe, Roux, Damien, Gernez, Coralie, Yelnik, Cécile, Poissy, Julien, Nizard, Mandy, Denies, Fanette, Gros, Helene, Mourad, Jean-Jacques, Sacco, Emmanuelle, Renet, Sophie, Ader, F., Yazdanpanah, Y., Mentre, F., Peiffer-Smadja, N., Lescure, F.X., Poissy, J., Bouadma, L., Timsit, J.F., Lina, B., Morfin-Sherpa, F., Bouscambert, M., Gaymard, A., Peytavin, G., Abel, L., Guedj, J., Andrejak, C., Burdet, C., Laouenan, C., Belhadi, D., Dupont, A., Alfaiate, T., Basli, B., Chair, A., Laribi, S., Level, J., Schneider, M., Tellier, M.C., Dechanet, A., Costagliola, D., Terrier, B., Ohana, M., Couffin-Cadiergues, S., Esperou, H., Delmas, C., Saillard, J., Fougerou, C., Moinot, L., Wittkop, L., Cagnot, C., Le Mestre, S., Lebrasseur-Longuet, D., Petrov-Sanchez, V., Diallo, A., Mercier, N., Icard, V., Leveau, B., Tubiana, S., Hamze, B., Gelley, A., Noret, M., D’Ortenzio, E., Puechal, O., Semaille, C., Welte, T., Paiva, J.A., Halanova, M., Kieny, M.P., Balssa, E., Birkle, C., Gibowski, S., Landry, E., Le Goff, A., Moachon, L., Moins, C., Wadouachi, L., Paul, C., Levier, A., Bougon, D., Djossou, F., Epelboin, L., Dellamonica, J., Marquette, C.H., Robert, C., Gibot, S., Senneville, E., Jean-Michel, V., Zerbib, Y., Chirouze, C., Boyer, A., Cazanave, C., Gruson, D., Malvy, D., Andreu, P., Quenot, J.P., Terzi, N., Faure, K., Chabartier, C., Le Moing, V., Klouche, K., Ferry, T., F, Valour, Gaborit, B., Canet, E., Le Turnier, P., Boutoille, D., Bani-Sadr, F., Benezit, F., Revest, M., Cameli, C., Caro, A., Um Tegue, MJ Ngo, Le Tulzo, Y., Laviolle, B., Laine, F., Thiery, G., Meziani, F., Hansmann, Y., Oulehri, W., Tacquard, C., Vardon-Bounes, F., Riu-Poulenc, B., Murris-Espin, M., Bernard, L., Garot, D., Hinschberger, O., Martinot, M., Bruel, C., Pilmis, B., Bouchaud, O., Loubet, P., Roger, C., Monnet, X., Figueiredo, S., Godard, V., Mira, J.P., Lachatre, M., Kerneis, S., Aboab, J., Sayre, N., Crockett, F., Lebeaux, D., Buffet, A., Diehl, J.L., Fayol, A., Hulot, J.S., Livrozet, M., Dessap, A Mekontso, Ficko, C., Stefan, F., Le Pavec, J., Mayaux, J., Ait-Oufella, H., Molina, J.M., Pialoux, G., Fartoukh, M., Textoris, J., Brossard, M., Essat, A., Netzer, E., Riault, Y., Ghislain, M., Beniguel, L., Genin, M., Gouichiche, L., Betard, C., Belkhir, L., Altdorfer, A., Centro, V Fraipont, Braz, S., Ribeiro, JM Ferreira, Alburqueque, R Roncon, Berna, M., Alexandre, M., Lamprecht, B., Egle, A., Greil, R., Joannidis, M., Patterson, Thomas F., Ponce, Philip O., Taylor, Barbara S., Patterson, Jan E., Bowling, Jason E., Javeri, Heta, Kalil, Andre C., Larson, LuAnn, Hewlett, Angela, Mehta, Aneesh K., Rouphael, Nadine G., Saklawi, Youssef, Scanlon, Nicholas, Traenkner, Jessica J., Trible, Ronald P., Jr., Walter, Emmanuel B., Ivey, Noel, Holland, Thomas L., Ruiz-Palacios, Guillermo M., Ponce de León, Alfredo, Rajme, Sandra, Hsieh, Lanny, Amin, Alpesh N., Watanabe, Miki, Lee, Helen S., Kline, Susan, Billings, Joanne, Noren, Brooke, Kim, Hyun, Bold, Tyler D., Tapson, Victor, Grein, Jonathan, Sutterwala, Fayyaz, Iovine, Nicole, Beattie, Lars K., Wakeman, Rebecca Murray, Shaw, Matthew, Jain, Mamta K., Mocherla, Satish, Meisner, Jessica, Luque, Amneris, Sweeney, Daniel A., Benson, Constance A., Ali, Farhana, Atmar, Robert L., El Sahly, Hana M., Whitaker, Jennifer, Falsey, Ann R., Branche, Angela R., Rozario, Cheryl, Pineda, Justino Regalado, Martinez-Orozco, José Arturo, Lye, David Chien, Ong, Sean WX., Chia, Po Ying, Young, Barnaby E., Sandkovsky, Uriel, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Cantos, Valeria D., Kelley, Colleen F., Rebolledo Esteinou, Paulina A., Kandiah, Sheetal, Doernberg, Sarah B., Crouch, Pierre-Cedric B., Jang, Hannah, Luetkemeyer, Anne F., Dwyer, Jay, Cohen, Stuart H., Thompson, George R., 3rd, Nguyen, Hien H., Finberg, Robert W., Wang, Jennifer P., Perez-Velazquez, Juan, Wessolossky, Mireya, Jackson, Patrick E.H., Bell, Taison D., West, Miranda J., Taiwo, Babafemi, Krueger, Karen, Perez, Johnny, Pearson, Triniece, Paules, Catharine I., Julian, Kathleen G., Ahmad, Danish, Hajduczok, Alexander G., Arguinchona, Henry, Arguinchona, Christa, Erdmann, Nathaniel, Goepfert, Paul, Ahuja, Neera, Frank, Maria G., Wyles, David, Young, Heather, Oh, Myoung-don, Park, Wan Beom, Kang, Chang Kyung, Marconi, Vincent, Moanna, Abeer, Cribbs, Sushma, Harrison, Telisha, Kim, Eu Suk, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Tan, Seow Yen, Shafi, Humaira, Chien, Jaime, Fong, Raymond KC., Murray, Daniel D., Lundgren, Jens, Nielsen, Henrik, Jensen, Tomas, Zingman, Barry S., Grossberg, Robert, Riska, Paul F., Yang, Otto O., Ahn, Jenny, Arias, Rubi, Rapaka, Rekha R., Hauser, Naomi, Campbell, James D., Short, William R., Tebas, Pablo, Baron, Jillian T., McLellan, Susan L.F., Blanton, Lucas S., Seashore, Justin B., Creech, C. Buddy, Rice, Todd W., Walker, Shannon, Thomsen, Isaac P., Lopez de Castilla, Diego, Van Winkle, Jason W., Riedo, Francis X., Pada, Surinder Kaur, Wang, Alvin DY., Lin, Li, Harkins, Michelle, Mertz, Gregory, Sosa, Nestor, Ann Chai, Louis Yi, Tambyah, Paul Anantharajah, Tham, Sai Meng, Archuleta, Sophia, Yan, Gabriel, Lindholm, David A., Markelz, Ana Elizabeth, Mende, Katrin, Mularski, Richard, Hohmann, Elizabeth, Torres-Soto, Mariam, Jilg, Nikolaus, Maves, Ryan C., Utz, Gregory C., George, Sarah L., Hoft, Daniel F., Brien, James D., Paredes, Roger, Mateu, Lourdes, Loste, Cora, Kumar, Princy, Thornton, Sarah, Mohanraj, Sharmila, Hynes, Noreen A., Sauer, Lauren M., Colombo, Christopher J., Schofield, Christina, Colombo, Rhonda E., Chambers, Susan E., Novak, Richard M., Wendrow, Andrea, Gupta, Samir K., Lee, Tida, Lalani, Tahaniyat, Holodniy, Mark, Chary, Aarthi, Huprikar, Nikhil, Ganesan, Anuradha, Ohmagari, Norio, Mikami, Ayako, Price, D. Ashley, Duncan, Christopher J.A., Dierberg, Kerry, Neumann, Henry J., Taylor, Stephanie N., Lacour, Alisha, Masri, Najy, Swiatlo, Edwin, Widmer, Kyle, Neaton, James D., Bessesen, Mary, Stephens, David S., Burgess, Timothy H., Uyeki, Timothy M., Walker, Robert, Marks, G. Lynn, Osinusi, Anu, Cao, Huyen, Cardoso, Anabela, de Bono, Stephanie, Schlichting, Douglas E., Chung, Kevin K., Ferreira, Jennifer L., Green, Michelle, Makowski, Mat, Wierzbicki, Michael R., Conrad, Tom M., El-Khorazaty, Jill Ann, Hill, Heather, Bonnett, Tyler, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Beigel, John H., Tomashek, Kay M., Ghazaryan, Varduhi, Beresnev, Tatiana, Nayak, Seema, Dodd, Lori E., Dempsey, Walla, Nomicos, Effie, Lee, Marina, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Yokum, Tammy, Arega, Janice, Florese, Ruth, Voell, Jocelyn D., Davey, Richard, Serrano, Ruth C., Wiley, Zanthia, Phadke, Varun K., Goepfert, Paul A., Gomez, Carlos A., Sofarelli, Theresa A., Certain, Laura, Imlay, Hannah N., Wolfe, Cameron R., Ko, Emily R., Engemann, John J., Felix, Nora Bautista, Wan, Claire R., Elmor, Sammy T., Bristow, Laurel R., Harkins, Michelle S., Iovine, Nicole M., Elie-Turenne, Marie-Carmelle, Tapson, Victor F., Choe, Pyoeng Gyun, Mularski, Richard A., Rhie, Kevin S., Hussein, Rezhan H., Ince, Dilek, Winokur, Patricia L., Takasaki, Jin, Saito, Sho, McConnell, Kimberly, Wyles, David L., Sarcone, Ellen, Grimes, Kevin A., Perez, Katherine, Janak, Charles, Whitaker, Jennifer A., Rebolledo, Paulina A., Gharbin, John, Lambert, Allison A., Zea, Diego F., Bainbridge, Emma, Hostler, David C., Hostler, Jordanna M., Shahan, Brian T., Ling, Evelyn, Go, Minjoung, Hubbard, Fleesie A., Chakrabarty, Melony, Laguio-Vila, Maryrose, Walsh, Edward E., Guirgis, Faheem, Marconi, Vincent C., Madar, Christian, Borgetti, Scott A., Levine, Corri, Nock, Joy, Candiotti, Keith, Rozman, Julia, Dangond, Fernando, Hyvert, Yann, Seitzinger, Andrea, Cross, Kaitlyn, Pettibone, Stephanie, Nayak, Seema U., Deye, Gregory A., Siempos, Ilias I., Belhadi, Drifa, Veiga, Viviane Cordeiro, Cavalcanti, Alexandre Biasi, Branch-Elliman, Westyn, Papoutsi, Eleni, Gkirgkiris, Konstantinos, Xixi, Nikoleta A., and Kotanidou, Anastasia

Published
2024
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3. Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history

Author

Wang, Wei, Lusvarghi, Sabrina, Subramanian, Rahul, Epsi, Nusrat J., Wang, Richard, Goguet, Emilie, Fries, Anthony C., Echegaray, Fernando, Vassell, Russell, Coggins, Si’Ana A., Richard, Stephanie A., Lindholm, David A., Mende, Katrin, Ewers, Evan C., Larson, Derek T., Colombo, Rhonda E., Colombo, Christopher J., Joseph, Janet O., Rozman, Julia S., Smith, Alfred, Lalani, Tahaniyat, Berjohn, Catherine M., Maves, Ryan C., Jones, Milissa U., Mody, Rupal, Huprikar, Nikhil, Livezey, Jeffrey, Saunders, David, Hollis-Perry, Monique, Wang, Gregory, Ganesan, Anuradha, Simons, Mark P., Broder, Christopher C., Tribble, David R., Laing, Eric D., Agan, Brian K., Burgess, Timothy H., Mitre, Edward, Pollett, Simon D., Katzelnick, Leah C., and Weiss, Carol D.

Published
2022
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4. Distinct blood inflammatory biomarker clusters stratify host phenotypes during the middle phase of COVID-19

Author

Blair, Paul W., Brandsma, Joost, Chenoweth, Josh, Richard, Stephanie A., Epsi, Nusrat J., Mehta, Rittal, Striegel, Deborah, Clemens, Emily G., Alharthi, Sultanah, Lindholm, David A., Maves, Ryan C., Larson, Derek T., Mende, Katrin, Colombo, Rhonda E., Ganesan, Anuradha, Lalani, Tahaniyat, Colombo, Christopher J., Malloy, Allison A., Snow, Andrew L., Schully, Kevin L., Lanteri, Charlotte, Simons, Mark P., Dumler, John S., Tribble, David, Burgess, Timothy, Pollett, Simon, Agan, Brian K., and Clark, Danielle V.

Published
2022
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5. Clinical factors and outcomes associated with immune non-response among virally suppressed adults with HIV from Africa and the United States

Author

Noiman, Adi, Esber, Allahna, Wang, Xun, Bahemana, Emmanuel, Adamu, Yakubu, Iroezindu, Michael, Kiweewa, Francis, Maswai, Jonah, Owuoth, John, Maganga, Lucas, Ganesan, Anuradha, Maves, Ryan C., Lalani, Tahaniyat, Colombo, Rhonda E., Okulicz, Jason F., Polyak, Christina, Crowell, Trevor A., Ake, Julie A., and Agan, Brian K.

Published
2022
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6. Estimating the Effect of Coronavirus Disease 2019 (COVID-19) Vaccination and Infection Variant on Post-COVID-19 Venous Thrombosis or Embolism Risk.

Author

O'Carroll, Andrew, Richard, Stephanie A, Byrne, Celia, Rusiecki, Jennifer, Wier, Ben, Berjohn, Catherine M, Fries, Anthony C, Lalani, Tahaniyat, Smith, Alfred G, Mody, Rupal M, Ganesan, Anuradha, Huprikar, Nikhil, Colombo, Rhonda E, Schofield, Christina, Lindholm, David A, Mende, Katrin, Jones, Milissa U, Flanagan, Ryan, Larson, Derek T, and Ewers, Evan C

Subjects
SARS-CoV-2, COVID-19, BOOSTER vaccines, VACCINATION status, VENOUS thrombosis
Abstract

Background Previous research has shown that vaccination reduces risk of post–coronavirus disease 2019 (COVID-19) venous thrombosis or embolism (VTE), but the effect of vaccine boosting on post-COVID-19 VTE risk reduction is unclear. We sought to estimate the effect of COVID-19 vaccination on the risk of post-COVID-19 VTE and to examine if the magnitude of this association differed among variant eras. Methods We performed a case-control study of Military Health System (MHS) beneficiaries who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2020–2022. Cases were defined as those with medically attended VTE within 90 days after their first positive SARS-CoV-2 test; controls were defined as SARS-CoV-2 infections without incident VTE by 90 days. Multivariate logistic regression estimated the odds of post-SARS-CoV-2 VTE based on pre-COVID-19 vaccine status, adjusting for other VTE risk factors. Results A total of 4646 MHS beneficiaries were included in this analysis; 1370 received a primary vaccine series and a further 790 received at least 1 booster at time of infection; 71 had VTE within 90 days of SARS-CoV-2 infection. Those who were vaccinated had lower odds of VTE (adjusted odds ratio [95% confidence interval]) compared to the unvaccinated following infection (primary series: 0.28 [.13–.62]; booster dose: 0.06 [.01–.46]). Post-COVID-19 VTE risk was lowest during the Omicron era, but VTEs were too rare to examine for an interaction of variant era and vaccine effect. Conclusions Among MHS beneficiaries, COVID-19 vaccination was associated with a reduced risk of post-COVID-19 VTE diagnosis; estimated risk reduction was larger among those who received a booster. [ABSTRACT FROM AUTHOR]

Published
2024
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7. SARS-CoV-2 infection is associated with self-reported post-acute neuropsychological symptoms within six months of follow-up

Author

Andronescu, Liana R., primary, Richard, Stephanie A., additional, Scher, Ann I., additional, Lindholm, David A., additional, Mende, Katrin, additional, Ganesan, Anuradha, additional, Huprikar, Nikhil, additional, Lalani, Tahaniyat, additional, Smith, Alfred, additional, Mody, Rupal M., additional, Jones, Milissa U., additional, Bazan, Samantha E., additional, Colombo, Rhonda E., additional, Colombo, Christopher J., additional, Ewers, Evan, additional, Larson, Derek T., additional, Maves, Ryan C., additional, Berjohn, Catherine M., additional, Maldonado, Carlos J., additional, English, Caroline, additional, Sanchez Edwards, Margaret, additional, Rozman, Julia S., additional, Rusiecki, Jennifer, additional, Byrne, Celia, additional, Simons, Mark P., additional, Tribble, David, additional, Burgess, Timothy H., additional, Pollett, Simon D., additional, and Agan, Brian K., additional

Published
2024
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10. Gut microbiome and antibiotic resistance effects during travelers’ diarrhea treatment and prevention

Author

Blake, Kevin S., primary, Schwartz, Drew J., additional, Paruthiyil, Srinand, additional, Wang, Bin, additional, Ning, Jie, additional, Isidean, Sandra D., additional, Burns, Daniel S., additional, Whiteson, Harris, additional, Lalani, Tahaniyat, additional, Fraser, Jamie A., additional, Connor, Patrick, additional, Troth, Tom, additional, Porter, Chad K., additional, Tribble, David R., additional, Riddle, Mark S., additional, Gutiérrez, Ramiro L., additional, Simons, Mark P., additional, and Dantas, Gautam, additional

Published
2023
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11. Evolution of HIV-1 envelope towards reduced neutralization sensitivity, as demonstrated by contemporary HIV-1 subtype B from the United States

Author

Wieczorek, Lindsay, primary, Sanders-Buell, Eric, additional, Zemil, Michelle, additional, Lewitus, Eric, additional, Kavusak, Erin, additional, Heller, Jonah, additional, Molnar, Sebastian, additional, Rao, Mekhala, additional, Smith, Gabriel, additional, Bose, Meera, additional, Nguyen, Amy, additional, Dhungana, Adwitiya, additional, Okada, Katherine, additional, Parisi, Kelly, additional, Silas, Daniel, additional, Slike, Bonnie, additional, Ganesan, Anuradha, additional, Okulicz, Jason, additional, Lalani, Tahaniyat, additional, Agan, Brian K., additional, Crowell, Trevor A., additional, Darden, Janice, additional, Rolland, Morgane, additional, Vasan, Sandhya, additional, Ake, Julie, additional, Krebs, Shelly J., additional, Peel, Sheila, additional, Tovanabutra, Sodsai, additional, and Polonis, Victoria R., additional

Published
2023
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12. Reliability, Validity, and Responsiveness of InFLUenza Patient-Reported Outcome (FLU-PRO©) Scores in Influenza-Positive Patients

Author

Powers, John H., III, Bacci, Elizabeth D., Guerrero, M. Lourdes, Leidy, Nancy Kline, Stringer, Sonja, Kim, Katherine, Memoli, Matthew J., Han, Alison, Fairchok, Mary P., Chen, Wei-Ju, Arnold, John C., Danaher, Patrick J., Lalani, Tahaniyat, Ridoré, Michelande, Burgess, Timothy H., Millar, Eugene V., Hernández, Andrés, Rodríguez-Zulueta, Patricia, Smolskis, Mary C., Ortega-Gallegos, Hilda, Pett, Sarah, Fischer, William, Gillor, Daniel, Macias, Laura Moreno, DuVal, Anna, Rothman, Richard, Dugas, Andrea, and Ruiz-Palacios, Guillermo M.

Published
2018
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13. 387. Understanding the Impact of COVID-19 on Cognitive Function Using a Scalable, App-based, Self-administered Tool in the Military

Author

Andronescu, Liana, primary, Richard, Stephanie A, additional, Hone, Emily, additional, Scher, Ann, additional, Lindholm, David, additional, Mende, Katrin, additional, Ganesan, Anuradha, additional, Huprikar, Nikhil, additional, Lalani, Tahaniyat, additional, Smith, Alfred, additional, Mody, Rupal, additional, Jones, Milissa U, additional, Colombo, Rhonda, additional, Ewers, Evan, additional, Berjohn, Catherine, additional, Maldonado, Carlos, additional, Edwards, Margaret Sanchez, additional, Rozman, Julia, additional, Rusiecki, Jennifer, additional, Byrne, Celia, additional, Simons, Mark P, additional, Tribble, David R, additional, Burgess, Timothy, additional, Rubin, Leah H, additional, Severson, Joan, additional, O’Connell, Robert, additional, Pollett, Simon, additional, and Agan, Brian, additional

Published
2023
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14. 441. Prior SARS-CoV-2 Diagnosis is a Risk Factor for Herpes Zoster in Younger Adults: A Nested Case-control Study in the EPICC Cohort

Author

Schmidt, Kat, primary, Richard, Stephanie A, additional, Berjohn, Catherine, additional, Lalani, Tahaniyat, additional, Smith, Alfred, additional, Mody, Rupal, additional, Lindholm, David, additional, Huprikar, Nikhil, additional, Saunders, David, additional, Colombo, Rhonda, additional, Jones, Milissa, additional, Flanagan, Ryan, additional, Ewers, Evan, additional, Chang, David, additional, Schofield, Christina, additional, Edwards, Margaret Sanchez, additional, Maldonado, Carlos, additional, Mende, Katrin, additional, Scher, Ann, additional, Rusiecki, Jennifer, additional, Byrne, Celia, additional, Wyatt, Andrew, additional, Simons, Mark P, additional, Tribble, David R, additional, O’Connell, Robert, additional, Agan, Brian, additional, Burgess, Timothy, additional, Pollett, Simon, additional, and Ganesan, Anuradha, additional

Published
2023
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15. 1573. Viral Blips While on Antiretroviral Therapy are Associated with Virologic Failure

Author

Fleit, Madeline, primary, Hsieh, Hsing-Chuan, additional, Colombo, Rhonda, additional, Schofield, Christina, additional, Berjohn, Catherine, additional, Lalani, Tahaniyat, additional, Blaylock, Jason, additional, Yabes, Joseph, additional, Joya, Christie, additional, Ewers, Evan, additional, Crowell, Trevor A, additional, Chu, Xiuping, additional, Agan, Brian, additional, and Ganesan, Anuradha, additional

Published
2023
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16. 437. Does “Long COVID” Resolve by One Year in U.S. Military Health System Beneficiaries?

Author

Richard, Stephanie A, primary, Byrne, Celia, additional, Rusiecki, Jennifer, additional, Berjohn, Catherine, additional, Lalani, Tahaniyat, additional, Smith, Alfred, additional, Mody, Rupal, additional, Ganesan, Anuradha, additional, Colombo, Rhonda, additional, Lindholm, David, additional, Morris, Michael, additional, Huprikar, Nikhil, additional, Colombo, Christopher, additional, Schofield, Christina, additional, Jones, Milissa U, additional, Mende, Katrin, additional, Saunders, David, additional, Livezey, Jeffrey, additional, Chang, David, additional, Ewers, Evan, additional, Maldonado, Carlos, additional, Scher, Ann, additional, Fries, Anthony C, additional, Maves, Ryan C, additional, Epsi, Nusrat J, additional, Schmidt, Kat, additional, Edwards, Margaret Sanchez, additional, Simons, Mark, additional, Tribble, David R, additional, O’Connell, Robert, additional, Agan, Brian, additional, Burgess, Timothy, additional, and Pollett, Simon, additional

Published
2023
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17. 1352. A Precision Medicine Approach to Predicting “Long COVID” through Machine Learning Analysis of Whole Blood Transcriptome Data

Author

Epsi, Nusrat J, primary, Richard, Stephanie A, additional, Chenoweth, Josh, additional, Lindholm, David, additional, Mende, Katrin, additional, Ganesan, Anuradha, additional, Huprikar, Nikhil, additional, Lalani, Tahaniyat, additional, Smith, Alfred, additional, Mody, Rupal, additional, Schofield, Christina, additional, Colombo, Rhonda E, additional, Flanagan, Ryan, additional, Ewers, Evan, additional, Berjohn, Catherine, additional, Saunders, David, additional, Jones, Milissa, additional, Edwards, Margaret, additional, Simons, Mark P, additional, O’Connell, Robert, additional, Tribble, David R, additional, Agan, Brian, additional, Burgess, Timothy, additional, Dalgard, Clifton, additional, and Pollett, Simon, additional

Published
2023
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20. Low Level Viremia Is Associated With Serious non-AIDS Events in People With HIV.

Author

Ganesan, Anuradha, Hsieh, Hsing-Chuan, Chu, Xiuping, Colombo, Rhonda E, Berjohn, Catherine, Lalani, Tahaniyat, Yabes, Joseph, Joya, Christie A, Blaylock, Jason, and Agan, Brian K

Subjects
HIV-positive persons, PROPORTIONAL hazards models, VIREMIA
Abstract

Background The consequences of low-level viremia in people with HIV are unclear. We used data from the US Military HIV Natural History Study to examine the association of low-level viremia (LLV) and serious non-AIDS events (SNAEs). Methods Included participants initiated antiretroviral therapy after 1996 and had ≥3 viral loads (VLs) measured, using an assay with a lower limit of detection of <50 copies/mL, ≥6 months after antiretroviral therapy initiation. VLs were categorized as lower levels of LLV (51–199 copies/mL), higher level of low-level viremia (HLLV; 200–999 copies/mL), and (VF; ≥200 copies/mL on 2 or more successive determinations or a single VL ≥1000 copies/mL), and virologic suppression (VS; ie, VL <50 copies/mL). Viral blips (ie, VLs between 50 and 999 copies/mL that are preceded and succeeded by VL <50 copies/mL) were analyzed in the VS category. Cox proportional hazards models were used to examine the association of LLV and SNAEs, adjusted hazard ratios and 95% confidence intervals are presented. Results A total of 439 (17.4%) SNAEs were recorded among the 2528 participants (93% male, 40% Caucasian, 43% African American) followed for a median of 11 years. In 8.5% and 4.6% of the participants, respectively, LLV and HLLV were the highest recorded viremia strata. Compared with VS, SNAEs were associated with LLV (1.3 [1.2–1.4]), HLLV (1.6 [1.5–1.7]), and virologic failure (1.7 [1.7–1.8]). Conclusions The results of this study suggest that LLV is associated with the occurrence of SNAEs and needs further study. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Decreased Self-reported Physical Fitness Following SARS-CoV-2 Infection and the Impact of Vaccine Boosters in a Cohort Study.

Author

Richard, Stephanie A, Scher, Ann I, Rusiecki, Jennifer, Byrne, Celia, Berjohn, Catherine M, Fries, Anthony C, Lalani, Tahaniyat, Smith, Alfred G, Mody, Rupal M, Ganesan, Anuradha, Huprikar, Nikhil, Colombo, Rhonda E, Colombo, Christopher J, Schofield, Christina, Lindholm, David A, Mende, Katrin, Morris, Michael J, Jones, Milissa U, Flanagan, Ryan, and Larson, Derek T

Subjects
SARS-CoV-2, BOOSTER vaccines, COVID-19, PHYSICAL fitness, MILITARY personnel
Abstract

Background The long-term effects of coronavirus disease 2019 (COVID-19) on physical fitness are unclear, and the impact of vaccination on that relationship is uncertain. Methods We compared survey responses in a 1-year study of US military service members with (n = 1923) and without (n = 1591) a history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We fit Poisson regression models to estimate the association between history of SARS-CoV-2 infection and fitness impairment, adjusting for time since infection, demographics, and baseline health. Results The participants in this analysis were primarily young adults aged 18–39 years (75%), and 71.5% were male. Participants with a history of SARS-CoV-2 infection were more likely to report difficulty exercising (38.7% vs 18.4%; P <.01), difficulty performing daily activities (30.4% vs 12.7%; P <.01), and decreased fitness test (FT) scores (42.7% vs 26.2%; P <.01) than those without a history of infection. SARS-CoV-2-infected participants were at higher risk of these outcomes after adjusting for other factors (unvaccinated: exercising: adjusted risk ratio [aRR], 3.99; 95% CI, 3.36–4.73; activities: aRR, 5.02; 95% CI, 4.09–6.16; FT affected: aRR, 2.55; 95% CI, 2.19–2.98). Among SARS-CoV-2-positive participants, full vaccination before infection was associated with a lower risk of post-COVID-19 fitness impairment (fully vaccinated: exercise: aRR, 0.81; 95% CI, 0.70–0.95; activities: aRR, 0.76; 95% CI, 0.64–0.91; FT: aRR, 0.87; 95% CI, 0.76–1.00; boosted: exercise: aRR, 0.62; 95% CI, 0.51–0.74; activities: aRR, 0.52; 95% CI, 0.41–0.65; FT: aRR, 0.59; 95% CI, 0.49–0.70). Conclusions In this study of generally young, healthy military service members, SARS-CoV-2 infection was associated with lower self-reported fitness and exercise capacity; vaccination and boosting were associated with lower risk of self-reported fitness loss. [ABSTRACT FROM AUTHOR]

Published
2023
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22. 273. Emergence of the SARS-CoV-2 Omicron Variant in the Pragmatic Assessment of Influenza Vaccine Effectiveness in the Department of Defense (PAIVED) Study

Author

Richard, Stephanie A, primary, Berjohn, Catherine M, additional, Collins, Limone, additional, Seshadri, Srihari, additional, Spooner, Christina, additional, Campbell, Wesley R, additional, Ganesan, Anuradha, additional, Fries, Anthony C, additional, Hrncir, David, additional, Lalani, Tahaniyat, additional, Warkentien, Tyler, additional, Markelz, Ana E, additional, Mende, Katrin, additional, McClenathan, Bruce, additional, Powers, John H, additional, Modi, Jitendrakumar, additional, Schofield, Christina, additional, Williams, Alan, additional, Colombo, Rhonda E, additional, and Burgess, Timothy, additional

Published
2022
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24. 1102. The Host Response to SARS-CoV-2 Infection Differs by Age

Author

Parsons, Emily, primary, Richard, Stephanie A, additional, Laing, Eric D, additional, Fries, Anthony C, additional, Livezey, Jeffrey, additional, Jones, Milissa, additional, Lindholm, David A, additional, Mende, Katrin, additional, Rozman, Julia S, additional, Ganesan, Anuradha, additional, Huprikar, Nikhil, additional, Lalani, Tahaniyat, additional, Smith, Alfred G, additional, Mody, Rupal, additional, Bazan, Samantha, additional, Saunders, David, additional, Colombo, Rhonda E, additional, Colombo, Christopher, additional, Ewers, Evan C, additional, Larson, Derek, additional, Maves, Ryan C, additional, Berjohn, Catherine M, additional, Maldonado, Carlos, additional, Simons, Mark P, additional, Tribble, David, additional, Agan, Brian, additional, Burgess, Timothy, additional, Pollett, Simon, additional, and Malloy, Allison M, additional

Published
2022
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25. 2200. Impact of COVID-19 Pandemic on Influenza-like Illness (ILI) Experience among Healthcare Workers in Military Treatment Facilities

Author

Liberg, Ryan, primary, Schofield, Christina, additional, Richard, Stephanie A, additional, Collins, Limone, additional, Spooner, Christina, additional, Seshadri, Srihari, additional, Ganesan, Anuradha, additional, Campbell, Wesley R, additional, Hrncir, David, additional, Lalani, Tahaniyat, additional, Warkentien, Tyler, additional, Mende, Katrin, additional, Markelz, Ana E, additional, Berjohn, Catherine M, additional, McClenathan, Bruce, additional, Modi, Jitendrakumar, additional, Williams, Alan, additional, Burgess, Timothy, additional, and Colombo, Rhonda E, additional

Published
2022
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26. 1066. Precision phenotyping of “long COVID” through machine learning

Author

Epsi, Nusrat J, primary, Lindholm, David A, additional, Ganesan, Anuradha, additional, Lalani, Tahaniyat, additional, Smith, Alfred G, additional, Mody, Rupal, additional, Jones, Milissa, additional, Bazan, Samantha, additional, Colombo, Rhonda E, additional, Colombo, Christopher, additional, Ewers, Evan C, additional, Larson, Derek, additional, Berjohn, Catherine M, additional, Maves, Ryan C, additional, Fries, Anthony C, additional, Scher, Ann, additional, Byrne, Celia, additional, Rusiecki, Jennifer, additional, Sanchez Edwards, Margaret, additional, Rozman, Julia S, additional, Mende, Katrin, additional, Simons, Mark P, additional, Tribble, David R, additional, Agan, Brian, additional, Burgess, Timothy, additional, Pollett, Simon, additional, and Richard, Stephanie A, additional

Published
2022
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27. 80. SARS-CoV-2 infection is associated with decreased reported physical fitness in a US military longitudinal cohort

Author

Richard, Stephanie A, primary, Scher, Ann, additional, Rusiecki, Jennifer, additional, Byrne, Celia, additional, Berjohn, Catherine M, additional, Fries, Anthony C, additional, Lalani, Tahaniyat, additional, Smith, Alfred G, additional, Mody, Rupal, additional, Ganesan, Anuradha, additional, Huprikar, Nikhil, additional, Colombo, Rhonda E, additional, Colombo, Christopher, additional, Lindholm, David A, additional, Mende, Katrin, additional, Jones, Milissa, additional, Larson, Derek, additional, Ewers, Evan C, additional, Bazan, Samantha, additional, Lanteri, Charlotte, additional, Saunders, David, additional, Maves, Ryan C, additional, Livezey, Jeffrey, additional, Edwards, Margaret Sanchez, additional, Rozman, Julia S, additional, Tribble, David R, additional, Agan, Brian, additional, Pollett, Simon, additional, Simons, Mark P, additional, and Burgess, Timothy, additional

Published
2022
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28. 2206. Pragmatic Assessment of Influenza Vaccine Effectiveness in the Department of Defense (PAIVED): Updates from Year 4 of a Multi-site Trial

Author

Burgess, Timothy, primary, Richard, Stephanie A, additional, Collins, Limone, additional, Spooner, Christina, additional, Seshadri, Srihari, additional, Schofield, Christina, additional, Ganesan, Anuradha, additional, Campbell, Wesley R, additional, Hrncir, David, additional, Lalani, Tahaniyat, additional, Warkentien, Tyler, additional, Mende, Katrin, additional, Markelz, Ana E, additional, Berjohn, Catherine M, additional, McClenathan, Bruce, additional, Modi, Jitendrakumar, additional, Williams, Alan, additional, and Colombo, Rhonda E, additional

Published
2022
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29. 2204. Pathogen Co-infections and Trends in Influenza-like Illness in PAIVED

Author

Richard, Stephanie A, primary, Schofield, Christina, additional, Collins, Limone, additional, Spooner, Christina, additional, Seshadri, Srihari, additional, Ganesan, Anuradha, additional, Campbell, Wesley R, additional, Hrncir, David, additional, Lalani, Tahaniyat, additional, Warkentien, Tyler, additional, Mende, Katrin, additional, Markelz, Ana E, additional, Berjohn, Catherine M, additional, McClenathan, Bruce, additional, Modi, Jitendrakumar, additional, Williams, Alan, additional, Burgess, Timothy, additional, and Colombo, Rhonda E, additional

Published
2022
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30. Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group streptococci

Author

Tellez, Adrian, Ambrosioni, Juan, Hernández-Meneses, Marta., Llopis Pérez, Jaime, Ripa, Marco, Chambers, Stephen T., Holland, David, Almela, M. (Manel), Fernández-Hidalgo, Núria, Almirante, Benito, Bouza, Emilio, Strahilevitz, Jacob, Hannan, Margaret M., Harkness, John, Kanafani, Zeina A., Lalani, Tahaniyat, Lang, Selwyn, Raymond, Nigel, Read, Kerry, Vinagradova, Tatiana, Woods, Christopher W., Wray, Dannah, Moreno Camacho, Ma. Asunción, Chu, Vivian H., Miró Meda, José M., International Collaboration on Endocarditis (ICE), Téllez, Adrián, Ambrosioni, Juan, Hernández-Meneses, Marta, Llopis, Jaume, Ripa, Marco, Chambers, Stephen T, Holland, David, Almela, Manel, Fernández-Hidalgo, Núria, Almirante, Benito, Bouza, Emilio, Strahilevitz, Jacob, Hannan, Margaret M, Harkness, John, Kanafani, Zeina A, Lalani, Tahaniyat, Lang, Selwyn, Raymond, Nigel, Read, Kerry, Vinogradova, Tatiana, Woods, Christopher W, Wray, Dannah, Moreno, Asuncion, Chu, Vivian H, and Miro, Jose M

Subjects
Microbiology (medical), Endocarditis, International collaboration on endocarditis, Streptococcus, Viridans group streptococci, Estreptococs, Endocarditis, Bacterial, Middle Aged, Viridans Streptococci, Infections, Infeccions, Granulicatella, Infectious Diseases, Abiotrophia, Humans, Hospital Mortality, Prospective Studies, Infective endocarditis
Abstract

Objective : To describe the clinical characteristics and outcome of Abiotrophia and Granulicatella infective endocarditis and compare them with Viridans group streptococci infective endocarditis. Methods : All patients in the International Collaboration on Endocarditis (ICE) - prospective cohort study (PCS) and the ICE-PLUS cohort were included (n=8112). Data from patients with definitive or possible IE due to Abiotrophia species, Granulicatella species and Viridans group streptococci was analyzed. A propensity score (PS) analysis comparing the ABI/GRA-IE and VGS-IE groups according to a 1:2 ratio was performed. Results : Forty-eight (0.64%) cases of ABI/GRA-IE and 1,292 (17.2%) VGS-IE were included in the analysis. The median age of patients with ABI/GRA-IE was lower than VGS-IE (48.1 years vs. 57.9 years; p=0.001). Clinical features and the rate of in-hospital surgery was similar between ABI/GRA-IE and VGS-IE (52.1% vs. 45.4%; p=0.366). Unadjusted in-hospital death was lower in ABI/GRA-IE than VGS-IE (2.1% vs. 8.8%; p=0.003), and cumulative six-month mortality was lower in ABI/GRA-IE than VGS-IE (2.1% vs. 11.9%; p

Published
2022

33. Telavancin versus Vancomycin for Hospital-Acquired Pneumonia due to Gram-positive Pathogens

Author

the ATTAIN Study Group, Rubinstein, Ethan, Lalani, Tahaniyat, Corey, G. Ralph, Kanafani, Zeina A., Nannini, Esteban C., Rocha, Marcelo G., Rahav, Galia, Niederman, Michael S., Kollef, Marin H., Shorr, Andrew F., Lee, Patrick C., Lentnek, Arnold L., Luna, Carlos M., Fagon, Jean-Yves, Torres, Antoni, Kitt, Michael M., Genter, Fredric C., Barriere, Steven L., Friedland, H. David, and Stryjewski, Martin E.

Published
2011
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34. A machine learning approach identifies distinct early-symptom cluster phenotypes which correlate with hospitalization, failure to return to activities, and prolonged COVID-19 symptoms.

Author

Epsi, Nusrat J., Powers, John H., Lindholm, David A., Mende, Katrin, Malloy, Allison, Ganesan, Anuradha, Huprikar, Nikhil, Lalani, Tahaniyat, Smith, Alfred, Mody, Rupal M., Jones, Milissa U., Bazan, Samantha E., Colombo, Rhonda E., Colombo, Christopher J., Ewers, Evan C., Larson, Derek T., Berjohn, Catherine M., Maldonado, Carlos J., Blair, Paul W., and Chenoweth, Josh

Subjects
COUGH, POST-acute COVID-19 syndrome, MACHINE learning, COVID-19, SYMPTOMS, PHENOTYPES
Abstract

Background: Accurate COVID-19 prognosis is a critical aspect of acute and long-term clinical management. We identified discrete clusters of early stage-symptoms which may delineate groups with distinct disease severity phenotypes, including risk of developing long-term symptoms and associated inflammatory profiles. Methods: 1,273 SARS-CoV-2 positive U.S. Military Health System beneficiaries with quantitative symptom scores (FLU-PRO Plus) were included in this analysis. We employed machine-learning approaches to identify symptom clusters and compared risk of hospitalization, long-term symptoms, as well as peak CRP and IL-6 concentrations. Results: We identified three distinct clusters of participants based on their FLU-PRO Plus symptoms: cluster 1 ("Nasal cluster") is highly correlated with reporting runny/stuffy nose and sneezing, cluster 2 ("Sensory cluster") is highly correlated with loss of smell or taste, and cluster 3 ("Respiratory/Systemic cluster") is highly correlated with the respiratory (cough, trouble breathing, among others) and systemic (body aches, chills, among others) domain symptoms. Participants in the Respiratory/Systemic cluster were twice as likely as those in the Nasal cluster to have been hospitalized, and 1.5 times as likely to report that they had not returned-to-activities, which remained significant after controlling for confounding covariates (P < 0.01). Respiratory/Systemic and Sensory clusters were more likely to have symptoms at six-months post-symptom-onset (P = 0.03). We observed higher peak CRP and IL-6 in the Respiratory/Systemic cluster (P < 0.01). Conclusions: We identified early symptom profiles potentially associated with hospitalization, return-to-activities, long-term symptoms, and inflammatory profiles. These findings may assist in patient prognosis, including prediction of long COVID risk. [ABSTRACT FROM AUTHOR]

Published
2023
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35. 385. SARS-CoV-2 Infections Among Military Personnel Deployed on the USNS COMFORT to New York City During the COVID-19 Pandemic and One-Year Follow-Up

Author

Cooper, Elizabeth, primary, Lee, Tida, additional, Laing, Eric, additional, Ritter, Andrew, additional, Lee, Melissa, additional, Baker, Matthew, additional, Baldino, Tyler, additional, Mcadoo, Terrance, additional, Nguyen, Huy, additional, Broder, Christopher C, additional, Epsi, Nusrat J, additional, Richard, Stephanie A, additional, Warkentien, Tyler, additional, Millar, Eugene, additional, Burgess, Timothy, additional, Kronmann, Karl, additional, and Lalani, Tahaniyat, additional

Published
2021
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36. 05. Pragmatic Assessment of Influenza Vaccine Effectiveness in the DoD (PAIVED): Updates from Year 3 of Multi-Site Trial

Author

Burgess, Timothy, primary, Richard, Stephanie A, additional, Collins, Limone, additional, Colombo, Rhonda E, additional, Ganesan, Anuradha, additional, Geaney, Casey, additional, Hrncir, David, additional, Lalani, Tahaniyat, additional, Markelz, Ana E, additional, Maves, Ryan C, additional, McClenathan, Bruce, additional, Mende, Katrin, additional, Modi, Jitu, additional, Montgomery, Jay R, additional, Schofield, Christina, additional, Seshadri, Srihari, additional, Skerrett, Catherine, additional, Spooner, Christina, additional, Utz, Gregory, additional, Warkentien, Tyler, additional, Williams, Alan, additional, and Coles, Christian L, additional

Published
2021
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37. 1338. Before and After: The Impact of the COVID-19 Pandemic on Influenza-Like Illness Trends in PAIVED

Author

Colombo, Rhonda E, primary, Richard, Stephanie A, additional, Schofield, Christina, additional, Collins, Limone, additional, Ganesan, Anuradha, additional, Geaney, Casey, additional, Hrncir, David, additional, Lalani, Tahaniyat, additional, Markelz, Ana E, additional, Maves, Ryan C, additional, McClenathan, Bruce, additional, Mende, Katrin, additional, Modi, Jitu, additional, Montgomery, Jay R, additional, Seshadri, Srihari, additional, Skerrett, Catherine, additional, Spooner, Christina, additional, Utz, Gregory, additional, Williams, Alan, additional, Burgess, Timothy, additional, and Coles, Christian L, additional

Published
2021
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39. 337. SARS-CoV-2 Viral Load Does Not Predict Incident Venous Thromboembolism in COVID-19

Author

Pollett, Simon, primary, Wier, Benjamin, additional, Richard, Stephanie A, additional, Fries, Anthony C, additional, Maves, Ryan C, additional, Utz, Gregory, additional, Lalani, Tahaniyat, additional, Mody, Rupal, additional, Ganesan, Anuradha, additional, Colombo, Rhonda E, additional, Colombo, Chris, additional, Lindholm, David A, additional, Madar, Cristian, additional, Chi, Sharon, additional, Huprikar, Nikhil, additional, Larson, Derek, additional, Bazan, Samantha, additional, Scher, Ann, additional, Rusiecki, Jennifer, additional, Byrne, Celia, additional, Mende, Katrin, additional, Simons, Mark P, additional, Tribble, David, additional, Agan, Brian, additional, and Burgess, Timothy, additional

Published
2021
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40. 677. Compliance and Performance Characteristics of Subject Collected Versus Health-care Worker Collected Nasal Swabs for Respiratory Viral Surveillance

Author

Kautz, Michelle, primary, Epsi, Nusrat J, additional, Richard, Stephanie A, additional, Colombo, Rhonda E, additional, Ganesan, Anuradha, additional, Collins, Limone, additional, Burgess, Timothy, additional, Maves, Ryan C, additional, Markelz, Ana E, additional, Geaney, Casey, additional, Seshadri, Srihari, additional, Utz, Gregory, additional, Mende, Katrin, additional, Hrncir, David, additional, Modi, Jitu, additional, Fries, Anthony C, additional, McClenathan, Bruce, additional, Schofield, Christina, additional, Montgomery, Jay R, additional, Skerrett, Catherine, additional, Spooner, Christina, additional, Coles, Christian L, additional, and Lalani, Tahaniyat, additional

Published
2021
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41. 34. Long-term clinical outcomes following SARS-CoV-2 infection include persistent symptoms and cardiovascular disease beyond 3 months post-infection

Author

Richard, Stephanie A, primary, Pollett, Simon, additional, Epsi, Nusrat J, additional, Maves, Ryan C, additional, Utz, Gregory, additional, Lalani, Tahaniyat, additional, Mody, Rupal, additional, Ganesan, Anuradha, additional, Colombo, Rhonda E, additional, Colombo, Chris, additional, Lindholm, David A, additional, Madar, Cristian, additional, Chi, Sharon, additional, Huprikar, Nikhil, additional, Larson, Derek, additional, Bazan, Samantha, additional, Byrne, Celia, additional, English, Caroline E, additional, Parmelee, Edward, additional, Mende, Katrin, additional, Simons, Mark, additional, Burgess, Timothy, additional, Tribble, David, additional, and Agan, Brian, additional

Published
2021
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43. 458. A Machine Learning Approach Identifies Distinct Early-Symptom Cluster Phenotypes Which Correlate with Severe SARS-CoV-2 Outcomes

Author

Epsi, Nusrat J, primary, Powers, John H, additional, Lindholm, David A, additional, Helfrich, Alison, additional, Huprikar, Nikhil, additional, Ganesan, Anuradha, additional, Lalani, Tahaniyat, additional, Mody, Rupal, additional, Madar, Cristian, additional, Bazan, Samantha, additional, Colombo, Rhonda E, additional, Larson, Derek, additional, Maves, Ryan C, additional, Utz, Gregory, additional, Tribble, David, additional, Agan, Brian, additional, Burgess, Timothy, additional, Malloy, Allison, additional, Pollett, Simon, additional, and Richard, Stephanie A, additional

Published
2021
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44. 450. Type I Interferon Autoantibodies Are Detected in Those with Critical COVID-19, Including a Young Female Patient

Author

Yee, Debra, primary, Tso, Marana, additional, Shaw, Elana, additional, Rosen, Lindsey B, additional, Samuels, Emily, additional, Bastard, Paul, additional, Casanova, Jean-Laurent, additional, Holland, Steven M, additional, Su, Helen C, additional, Richard, Stephanie A, additional, Mende, Katrin, additional, Lalani, Tahaniyat, additional, Lindholm, David A, additional, Simons, Mark P, additional, Tribble, David, additional, Malloy, Allison, additional, Laing, Eric, additional, Agan, Brian, additional, Pollett, Simon, additional, Burgess, Timothy, additional, and Snow, Andrew L, additional

Published
2021
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46. Infective Endocarditis in Patients on Chronic Hemodialysis

Author

Pericàs, Juan M., primary, Llopis, Jaume, additional, Jiménez-Exposito, Maria Jesús, additional, Kourany, Wissam M., additional, Almirante, Benito, additional, Carosi, Giampiero, additional, Durante-Mangoni, Emanuele, additional, Fortes, Claudio Querido, additional, Giannitsioti, Efthymia, additional, Lerakis, Stamatios, additional, Montagna-Mella, Rodrigo, additional, Ambrosioni, Juan, additional, Tan, Ru-San, additional, Mestres, Carlos A., additional, Wray, Dannah, additional, Pachirat, Orathai, additional, Moreno, Asuncion, additional, Chu, Vivian H., additional, de Lazzari, Elisa, additional, Fowler, Vance G., additional, Miró, Jose M., additional, Clara, Liliana, additional, Sanchez, Marisa, additional, Casabé, José, additional, Cortes, Claudia, additional, Nacinovich, Francisco, additional, Oses, Pablo Fernandez, additional, Ronderos, Ricardo, additional, Sucari, Adriana, additional, Thierer, Jorge, additional, Altclas, Javier, additional, Kogan, Silvia, additional, Spelman, Denis, additional, Athan, Eugene, additional, Harris, Owen, additional, Kennedy, Karina, additional, Tan, Ren, additional, Gordon, David, additional, Papanicolas, Lito, additional, Korman, Tony, additional, Kotsanas, Despina, additional, Dever, Robyn, additional, Jones, Phillip, additional, Konecny, Pam, additional, Lawrence, Richard, additional, Rees, David, additional, Ryan, Suzanne, additional, Feneley, Michael P., additional, Harkness, John, additional, Post, Jeffrey, additional, Reinbott, Porl, additional, Gattringer, Rainer, additional, Wiesbauer, Franz, additional, Andrade, Adriana Ribas, additional, Passos de Brito, Ana Cláudia, additional, Guimarães, Armenio Costa, additional, Grinberg, Max, additional, Mansur, Alfredo José, additional, Siciliano, Rinaldo Focaccia, additional, Varejao Strabelli, Tania Mara, additional, Campos Vieira, Marcelo Luiz, additional, de Medeiros Tranchesi, Regina Aparecida, additional, Paiva, Marcelo Goulart, additional, de Oliveira Ramos, Auristela, additional, Weksler, Clara, additional, Ferraiuoli, Giovanna, additional, Golebiovski, Wilma, additional, Lamas, Cristiane, additional, Karlowsky, James A., additional, Keynan, Yoav, additional, Morris, Andrew M., additional, Rubinstein, Ethan, additional, Jones, Sandra Braun, additional, Garcia, Patricia, additional, Cereceda, M., additional, Fica, Alberto, additional, Mella, Rodrigo Montagna, additional, Fernandez, Ricardo, additional, Franco, Liliana, additional, Gonzalez, Javier, additional, Jaramillo, Astrid Natalia, additional, Barsic, Bruno, additional, Bukovski, Suzana, additional, Krajinovic, Vladimir, additional, Pangercic, Ana, additional, Rudez, Igor, additional, Vincelj, Josip, additional, Freiberger, Tomas, additional, Pol, Jiri, additional, Zaloudikova, Barbora, additional, Ashour, Zainab, additional, El Kholy, Amani, additional, Mishaal, Marwa, additional, Osama, Dina, additional, Rizk, Hussien, additional, Aissa, Neijla, additional, Alauzet, Corentine, additional, Alla, Francois, additional, Campagnac, CHU Catherine, additional, Doco-Lecompte, Thanh, additional, Selton-Suty, Christine, additional, Casalta, Jean-Paul, additional, Fournier, Pierre-Edouard, additional, Habib, Gilbert, additional, Raoult, Didier, additional, Thuny, Franck, additional, Delahaye, Francois, additional, Delahaye, Armelle, additional, Vandenesch, Francois, additional, Donal, Erwan, additional, Donnio, Pierre Yves, additional, Flecher, Erwan, additional, Michelet, Christian, additional, Revest, Matthieu, additional, Tattevin, Pierre, additional, Chevalier, Florent, additional, Jeu, Antoine, additional, Rémadi, Jean Paul, additional, Rusinaru, Dan, additional, Tribouilloy, Christophe, additional, Bernard, Yvette, additional, Chirouze, Catherine, additional, Hoen, Bruno, additional, Leroy, Joel, additional, Plesiat, Patrick, additional, Naber, Christoph, additional, Neuerburg, Carl, additional, Mazaheri, Bahram, additional, Sophia Athanasia, Carl Neuerburg, additional, Deliolanis, Ioannis, additional, Giamarellou, Helen, additional, Thomas, Tsaganos, additional, Mylona, Elena, additional, Paniara, Olga, additional, Papanicolaou, Konstantinos, additional, Pyros, John, additional, Skoutelis, Athanasios, additional, Papanikolaou, Konstantinos, additional, Sharma, Gautam, additional, Francis, Johnson, additional, Nair, Lathi, additional, Thomas, Vinod, additional, Venugopal, Krishnan, additional, Hannan, Margaret M., additional, Hurley, John P., additional, Wanounou, Maor, additional, Gilon, Dan, additional, Israel, Sarah, additional, Korem, Maya, additional, Strahilevitz, Jacob, additional, Iossa, Domenico, additional, Orlando, Serena, additional, Ursi, Maria Paola, additional, Pafundi, Pia Clara, additional, D’Amico, Fabiana, additional, Bernardo, Mariano, additional, Cuccurullo, Susanna, additional, Dialetto, Giovanni, additional, Covino, Franco Enrico, additional, Manduca, Sabrina, additional, Della Corte, Alessandro, additional, De Feo, Marisa, additional, Tripodi, Marie Françoise, additional, Cecchi, Enrico, additional, De Rosa, Francesco, additional, Forno, Davide, additional, Imazio, Massimo, additional, Trinchero, Rita, additional, Grossi, Paolo, additional, Lattanzio, Mariangela, additional, Toniolo, Antonio, additional, Goglio, Antonio, additional, Raglio, Annibale, additional, Ravasio, Veronica, additional, Rizzi, Marco, additional, Suter, Fredy, additional, Magri, Silvia, additional, Signorini, Liana, additional, Kanafani, Zeina, additional, Kanj, Souha S., additional, Sharif-Yakan, Ahmad, additional, Abidin, Imran, additional, Tamin, Syahidah Syed, additional, Martínez, Eduardo Rivera, additional, Soto Nieto, Gabriel Israel, additional, van der Meer, Jan T.M., additional, Chambers, Stephen, additional, Holland, David, additional, Morris, Arthur, additional, Raymond, Nigel, additional, Read, Kerry, additional, Murdoch, David R., additional, Dragulescu, Stefan, additional, Ionac, Adina, additional, Mornos, Cristian, additional, Butkevich, O.M., additional, Chipigina, Natalia, additional, Kirill, Ozerecky, additional, Vadim, Kulichenko, additional, Vinogradova, Tatiana, additional, Edathodu, Jameela, additional, Halim, Magid, additional, Liew, Yee-Yun, additional, Lejko-Zupanc, Tatjana, additional, Logar, Mateja, additional, Mueller-Premru, Manica, additional, Commerford, Patrick, additional, Commerford, Anita, additional, Deetlefs, Eduan, additional, Hansa, Cass, additional, Ntsekhe, Mpiko, additional, Almela, Manel, additional, Azqueta, Manuel, additional, Brunet, Merce, additional, Castro, Pedro, additional, De Lazzari, Elisa, additional, Falces, Carlos, additional, Fuster, David, additional, Fita, Guillermina, additional, Garcia- de- la- Maria, Cristina, additional, Garcia-Gonzalez, Javier, additional, Gatell, Jose M., additional, Marco, Francesc, additional, Miró, José M., additional, Ortiz, José, additional, Ninot, Salvador, additional, Paré, J. Carlos, additional, Pericas, Juan M., additional, Quintana, Eduard, additional, Ramirez, Jose, additional, Rovira, Irene, additional, Sandoval, Elena, additional, Sitges, Marta, additional, Tellez, Adrian, additional, Tolosana, José M., additional, Vidal, Barbara, additional, Vila, Jordi, additional, Anguera, Ignasi, additional, Font, Bernat, additional, Guma, Joan Raimon, additional, Bermejo, Javier, additional, Bouza, Emilio, additional, Garcia Fernández, Miguel Angel, additional, Gonzalez-Ramallo, Victor, additional, Marín, Mercedes, additional, Muñoz, Patricia, additional, Pedromingo, Miguel, additional, Roda, Jorge, additional, Rodríguez-Créixems, Marta, additional, Solis, Jorge, additional, Fernandez-Hidalgo, Nuria, additional, Tornos, Pilar, additional, de Alarcón, Arístides, additional, Parra, Ricardo, additional, Alestig, Eric, additional, Johansson, Magnus, additional, Olaison, Lars, additional, Snygg-Martin, Ulrika, additional, Pachirat, Pimchitra, additional, Pussadhamma, Burabha, additional, Senthong, Vichai, additional, Casey, Anna, additional, Elliott, Tom, additional, Lambert, Peter, additional, Watkin, Richard, additional, Eyton, Christina, additional, Klein, John L., additional, Bradley, Suzanne, additional, Kauffman, Carol, additional, Bedimo, Roger, additional, Corey, G. Ralph, additional, Crowley, Anna Lisa, additional, Douglas, Pamela, additional, Drew, Laura, additional, Holland, Thomas, additional, Lalani, Tahaniyat, additional, Mudrick, Daniel, additional, Samad, Zaniab, additional, Sexton, Daniel, additional, Stryjewski, Martin, additional, Wang, Andrew, additional, Woods, Christopher W., additional, Cantey, Robert, additional, Steed, Lisa, additional, Dickerman, Stuart A., additional, Bonilla, Hector, additional, DiPersio, Joseph, additional, Salstrom, Sara-Jane, additional, Baddley, John, additional, Patel, Mukesh, additional, Peterson, Gail, additional, Stancoven, Amy, additional, Levine, Donald, additional, Riddle, Jonathan, additional, Rybak, Michael, additional, and Cabell, Christopher H., additional

Published
2021
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47. COVID-19 Patient-Reported Symptoms Using FLU-PRO Plus in a Cohort Study: Associations With Infecting Genotype, Vaccine History, and Return to Health.

Author

Richard, Stephanie A, Epsi, Nusrat J, Lindholm, David A, Malloy, Allison M W, Maves, Ryan C, Berjohn, Catherine M, Lalani, Tahaniyat, Smith, Alfred G, Mody, Rupal M, Ganesan, Anuradha, Huprikar, Nikhil, Colombo, Rhonda E, Colombo, Christopher J, Madar, Cristian, Jones, Milissa U, Larson, Derek T, Ewers, Evan C, Bazan, Samantha, Fries, Anthony C, and Maldonado, Carlos J

Subjects
SARS-CoV-2, INFLUENZA, SARS-CoV-2 Delta variant, COVID-19, PROPORTIONAL hazards models, SYMPTOMS
Abstract

Background Patient-reported outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are an important measure of the full burden of coronavirus disease (COVID). Here, we examine how (1) infecting genotype and COVID-19 vaccination correlate with inFLUenza Patient-Reported Outcome (FLU-PRO) Plus score, including by symptom domains, and (2) FLU-PRO Plus scores predict return to usual activities and health. Methods The ep idemiology, i mmunology, and c linical c haracteristics of pandemic infectious diseases (EPICC) study was implemented to describe the short- and long-term consequences of SARS-CoV-2 infection in a longitudinal, observational cohort. Multivariable linear regression models were run with FLU-PRO Plus scores as the outcome variable, and multivariable Cox proportional hazards models evaluated effects of FLU-PRO Plus scores on return to usual health or activities. Results Among the 764 participants included in this analysis, 63% were 18–44 years old, 40% were female, and 51% were White. Being fully vaccinated was associated with lower total scores (β = −0.39; 95% CI, −0.57 to −0.21). The Delta variant was associated with higher total scores (β = 0.25; 95% CI, 0.05 to 0.45). Participants with higher FLU-PRO Plus scores were less likely to report returning to usual health and activities (health: hazard ratio [HR], 0.46; 95% CI, 0.37 to 0.57; activities: HR, 0.56; 95% CI, 0.47 to 0.67). Fully vaccinated participants were more likely to report returning to usual activities (HR, 1.24; 95% CI, 1.04 to 1.48). Conclusions Full SARS-CoV-2 vaccination is associated with decreased severity of patient-reported symptoms across multiple domains, which in turn is likely to be associated with earlier return to usual activities. In addition, infection with the Delta variant was associated with higher FLU-PRO Plus scores than previous variants, even after controlling for vaccination status. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Risk Factors Associated With Chronic Liver Enzyme Elevation in Persons With HIV Without Hepatitis B or C Coinfection in the Combination Antiretroviral Therapy Era

Author

Wood, Shannon, primary, Won, Seung Hyun, additional, Hsieh, Hsing-Chuan, additional, Lalani, Tahaniyat, additional, Kronmann, Karl, additional, Maves, Ryan C, additional, Utz, Gregory, additional, Schofield, Christina, additional, Colombo, Rhonda E, additional, Okulicz, Jason F, additional, Blaylock, Jason, additional, Agan, Brian K, additional, and Ganesan, Anuradha, additional

Published
2021
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49. SARS-CoV-2 Infections and Serologic Responses Among Military Personnel Deployed on the USNS COMFORT to New York City During the COVID-19 Pandemic

Author

Lalani, Tahaniyat, primary, Lee, Tida K, additional, Laing, Eric D, additional, Ritter, Andrew, additional, Cooper, Elizabeth, additional, Lee, Melissa, additional, Baker, Matthew, additional, Baldino, Tyler, additional, Mcadoo, Terrance, additional, Phogat, Shreshta, additional, Samuels, Emily, additional, Nguyen, Huy, additional, Broder, Christopher C, additional, Epsi, Nusrat, additional, Richard, Stephanie A, additional, Warkentien, Tyler E, additional, Millar, Eugene V, additional, Burgess, Timothy, additional, and Kronmann, Karl C, additional

Published
2021
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50. 185. Despite the Availability of Free Testing and Care Testing for Extragenital Sexually Transmitted Infections in a Cohort of Hiv-infected Department of Defense Beneficiaries Is Low and Similar to the Rates Observed Nationwide

Author

Ganesan, Anuradha, primary, Wang, Xun, additional, Blaylock, Jason M, additional, Okulicz, Jason, additional, Maves, Ryan C, additional, Colombo, Rhonda, additional, Utz, Gregory, additional, Schofield, Christina, additional, Kronmann, Karl, additional, Lalani, Tahaniyat, additional, Garges, Eric, additional, and Agan, Brian, additional

Published
2020
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