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1. Age-Related Differences in the Presentation, Management, and Clinical Outcomes of 100,000 Patients With Venous Thromboembolism in the RIETE Registry

Author

Adarraga, M.D., Alberich-Conesa, A., Aibar, J., Alda-Lozano, A., Alfonso, J., Amado, C., Angelina-García, M., Arcelus, J.I., Ballaz, A., Barba, R., Barbagelata, C., Barrón, M., Barrón-Andrés, B., Bascuñana, J., Beddar-Chaib, F., Blanco-Molina, A., Caballero, J.C., Castellanos, G., Chasco, L., Criado, J., De Ancos, C., Del Toro, J., Demelo-Rodríguez, P., De Juana-Izquierdo, C., Díaz-Brasero, A.M., Díaz-Peromingo, J.A., Dubois-Silva, A., Escribano, J.C., Falgá, C., Farfán-Sedano, A.I., Fernández-Aracil, C., Fernández-Capitán, C., Fernández-Jiménez, B., Fernández-Reyes, J.L., Fidalgo, M.A., Francisco, I., Gabara, C., Galeano-Valle, F., García-Bragado, F., García-Ortega, A., Gavín-Sebastián, O., Gil De Gómez, M.A., Gil-Díaz, A., Gómez-Cuervo, C., González-Munera, A., Grau, E., Guirado, L., Gutiérrez, J., Hernández-Blasco, L., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Jiménez, R., Jou, I., Joya, M.D., Lainez-Justo, S., Lecumberri, R., León-Ramírez, J.M., Llamas, P., Lobo, J.L., López-Jiménez, L., López-Miguel, P., López-Núñez, J.J., López-Ruiz, A., López-Sáez, J.B., Lorenzo, A., Lumbierres, M., Madridano, O., Maestre, A., Marchena, P.J., Marcos, M., Martín del Pozo, M., Martín-Martos, F., Maza, J.M., Mena, E., Mercado, M.I., Moisés, J., Monreal, M., Morales, M.V., Navas, M.S., Nieto, J.A., Núñez-Fernández, M.J., Olid, M., Ordieres-Ortega, L., Ortiz, M., Osorio, J., Otálora, S., Otero, R., Pacheco-Gómez, N., Pagán, J., Palomeque, A.C., Paredes, E., Parra-Caballero, P., Parra-Rosado, P., Pedrajas, J.M., Pérez-Ductor, C., Pérez-Pinar, M., Peris, M.L., Pesce, M.L., Porras, J.A., Puchades, R., Rivera-Cívico, F., Rodríguez-Cobo, A., Rosa, V., Romero-Brugera, M., Ruiz-Artacho, P., Ruiz-Giménez, N., Ruiz-Ruiz, J., Salgueiro, G., Sancho, T., Sendín, V., Sigüenza, P., Soler, S., Suárez-Fernández, S., Tirado, R., Torrents-Vilar, A., Torres, M.I., Trujillo-Santos, J., Uresandi, F., Valle, R., Varona, J.F., Villalobos, A., Villares, P., Ay, C., Nopp, S., Pabinger, I., Vanassche, T., Verhamme, P., Verstraete, A., Yoo, H.H.B., Montenegro, A.C., Morales, S.N., Roa, J., Hirmerova, J., Malý, R., Bertoletti, L., Bura-Riviere, A., Catella, J., Chopard, R., Couturaud, F., Espitia, O., Grange, C., Leclercq, B., Le Mao, R., Mahé, I., Moustafa, F., Plaisance, L., Sarlon-Bartoli, G., Suchon, P., Versini, E., Schellong, S., Brenner, B., Dally, N., Tzoran, I., Sadeghipour, P., Rashidi, F., Abenante, A., Barillari, G., Basaglia, M., Bilora, F., Bissacco, D., Bortoluzzi, C., Brandolin, B., Casana, R., Ciammaichella, M., Colaizzo, D., Dentali, F., Di Micco, P., Grandone, E., Imbalzano, E., Lambertenghi-Deliliers, D., Negro, F., Pesavento, R., Poz, A., Prandoni, P., Scarinzi, P., Siniscalchi, C., Taflaj, B., Tufano, A., Visonà, A., Vo Hong, N., Zalunardo, B., Paluga, R., Skride, A., Kigitovica, D., Fonseca, S., Marques, R., Meireles, J., Pinto, S., Bosevski, M., Trajkova, M., Zdraveska, M., Bounameaux, H., Mazzolai, L., Aujayeb, A., Caprini, J.A., Weinberg, I., Bui, H.M., Ortega, Alberto García, Jiménez, David, Pedro-Tudela, Ana, Pérez-Ductor, Cristina, Fernández-Capitán, Carmen, Falgá, Conxita, Skride, Andris, Siniscalchi, Carmine, Weinberg, Ido, and Monreal, Manuel

Published
2024
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2. A prognostic score to identify women at increased risk for abnormal uterine bleeding during anticoagulation for venous thromboembolism

Author

Monreal, Manuel, Prandoni, Paolo, Brenner, Benjamin, Farge-Bancel, Dominique, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Schellong, Sebastian, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Verhamme, Peter, Caprini, Joseph A., Bui, Hanh My, Adarraga, M.D., Agudo, P., Amado, C., Arcelus, J.I., Ballaz, A., Bascuñana, J., Barba, R., Barbagelata, C., Barrón, M., Barrón-Andrés, B., Blanco-Molina, A., Beddar Chaib, F., Botella, E., Cañas, I., Carrero-Arribas, R., Casado, I., Cerdá, P., Chasco, L., Criado, J., de Ancos, C., de Miguel, J., del Toro, J., Demelo-Rodríguez, P., Díaz-Brasero, A.M., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Domínguez, I.M., Dubois-Silva, A., Escribano, J.C., Espósito, F., Farfán-Sedano, A.I., Falgá, C., Fernández-Capitán, C., Fernández-Jiménez, B., Fernández-Muixi, J., Fernández-Reyes, J.L., Font, C., Francisco, I., Galeano-Valle, F., García, M.A., García-Bragado, F., García de Herreros, M., Gavín-Blanco, O., Gil-Díaz, A., Gómez-Cuervo, C., Gómez-Mosquera, A.M., Gonzalez-Moreno, M., Grau, E., Guirado, L., Gutiérrez, J., Hernández-Blasco, L., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Jou, I., Joya, M.D., Lacruz, B., Lainez-Justo, S., A, Latorre, J, Lima, Jl, Lobo, López-De la Fuente, M., López-Jiménez, L., López-Meseguer, M., López-Miguel, P., López-Núñez, J.J., López-Reyes, R., López-Sáez, J.B., Lorente, M.A., Lorenzo, A., Madridano, O., Maestre, A., Marchena, P.J., Martín-Guerra, J.M., Martín-Martos, F., Mellado, M., Mena, E., Moisés, J., Mercado, M.I., Monreal, M., Muñoz-Blanco, A., Muñoz-Gamito, G., Morales, M.V., Nieto, J.A., Noguera-Gras, E., Núñez-Fernández, M.J., Olid-Velilla, M., Osorio, J., Otalora, S., Otero, R., Paredes-Ruiz, D., Parra, P., Parra, V., Pedrajas, J.M., Pérez-López, M., Peris, M.L., Pesce, M.L., Porras, J.A., Poyo-Molina, J., Puchades, R., Riera-Mestre, A., Rivera-Civico, F., Rivera-Gallego, A., Roca, M., Rosa, V., Rodríguez-Cobo, A., Rodríguez-Matute, C., Ruiz-Artacho, P., Ruiz-Giménez, N., Ruiz-Ruiz, J., Salgueiro, G., Sancho, T., Sendín, V., Sigüenza, P., Soler, S., Suárez-Rodríguez, B., Suriñach, J.M., Tiberio, G., Torres, M.I., Torres-Sánchez, A., Trujillo-Santos, J., Uresandi, F., Usandizaga, E., Valle, R., Varona, J.F., Vela, L., Vela, J.R., Villalobos, A., Villares, P., Ay, C., Nopp, S., Pabinger, I., Engelen, M.M., Martens, C., Verhamme, P., Yoo, H.H.B., Arguello, J.D., Montenegro, A.C., Roa, J., Hirmerova, J., Malý, R., Accassat, S., Bertoletti, L., Bura-Riviere, A., Catella, J., Chopard, R., Couturaud, F., Espitia, O., El Harake, S., Le Mao, R., Mahé, I., Moustafa, F., Plaisance, L., Sarlon-Bartoli, G., Suchon, P., Versini, E., Schellong, S., Braester, A., Brenner, B., Kenet, G., Tzoran, I., Sadeghipour, P., Basaglia, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., De Angelis, A., Dentali, F., Di Micco, P., Imbalzano, E., Merla, S., Pesavento, R., Prandoni, P., Siniscalchi, C., Tufano, A., Visonà, A., Vo Hong, N., Zalunardo, B., Kigitovica, D., Rusa, E., Skride, A., Fonseca, S., Manuel, M., Meireles, J., Bosevski, M., Eftimova, A., Zdraveska, M., Bounameaux, H., Mazzolai, L., Aujayeb, A., Caprini, J.A., Weinberg, I., Bui, H.M., Sarlon-Bartoli, Gabrielle, Criado, Juan, Middeldorp, Saskia, Nieto, José Antonio, Díaz-Pedroche, María del Carmen, Moustafa, Farès, Ruiz-Giménez, Nuria, and DI Micco, Pierpaolo

Published
2023
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3. COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding

Author

Adarraga, M.D., Alberich-Conesa, A., Amado, C., Amorós, S., Arcelus, J.I., Ballaz, A., Barba, R., Barbagelata, C., Barrón, M., Barrón-Andrés, B., Blanco-Molina, A., Botella, E., Carrero, R., Casado, I., Criado, J., del Toro, J., De Ancos, C., De Juana-Izquierdo, C., Demelo-Rodríguez, P., Díaz-Brasero, A.M., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Dubois-Silva, A., Escribano, J.C., Espósito, F., Falgá, C., Farfán-Sedano, A.I., Fernández-Capitán, C., Fernández-Jiménez, B., Fernández-Muixi, J., Fernández-Reyes, J.L., Font, C., Francisco, I., Galeano-Valle, F., García, M.A., García de Herreros, M., García-Bragado, F., García-Ortega, A., Gavín-Sebastián, O., Gil-Díaz, A., Gil-Hernández, A., Gómez-Cuervo, C., Gómez-Mosquera, A.M., González-Martínez, J., Grau, E., Guirado, L., Gutiérrez, J., Hernández-Blasco, L., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Jou, I., Joya, M.D., Lacruz, B., Lalueza, A., Lainez-Justo, S., Lecumberri, R., León-Ramírez, J.M., Lobo, J.L., López-De la Fuente, M., López-Jiménez, L., López-Miguel, P., López-Núñez, J.J., López-Reyes, R., López-Ruiz, A., López-Sáez, J.B., Lorente, M.A., Lorenzo, A., Lumbierres, M., Madridano, O., Maestre, A., Mas-Maresma, L., Marcos, M., Martín-Guerra, J.M., Martín-Martos, F., Mellado, M., Mena, E., Mercado, M.I., Moisés, J., Monreal, M., Muñoz-Blanco, A., Muñoz-Gamito, G., Nieto, J.A., Núñez-Fernández, M.J., Osorio, J., Otalora, S., Pacheco-Gómez, N., Paredes-Ruiz, D., Parra, P., Pedrajas, J.M., Pérez-Ductor, C., Pérez-Jacoiste, A., Pérez-Pérez, J.L., Peris, M.L., Pesce, M.L., Porras, J.A., Poyo-Molina, J., Puchades, R., Riera-Mestre, A., Rivera-Civico, F., Rivera-Gallego, A., Roca, M., Rubio, C.M., Rosa, V., Rodríguez-Cobo, A., Ruiz-Giménez, N., Ruiz-Ruiz, J., Salgueiro, G., Sancho, T., Sendín, V., Sigüenza, P., Soler, S., Suriñach, J.M., Tiberio, G., Tolosa, C., Torres, M.I., Trujillo-Santos, J., Uresandi, F., Usandizaga, E., Valle, R., Varona, J.F., Vela, J.R., Vela, L., Vidal, G., Villalobos, A., Villares, P., Ay, C., Nopp, S., Pabinger, I., Engelen, M., Martens, C., Verhamme, P., Yoo, H.H.B., Arguello, J.D., Montenegro, A.C., Roa, J., Hirmerova, J., Malý, R., Accassat, S., Bertoletti, L., Bura-Riviere, A., Catella, J., Chopard, R., Couturaud, F., Espitia, O., Grange, C., Leclercq, B., Le Mao, R., Mahé, I., Moustafa, F., Plaisance, L., Poenou, G., Sarlon-Bartoli, G., Suchon, P., Versini, E., Schellong, S., Braester, A., Brenner, B., Kenet, G., Najib, D., Tzoran, I., Farrashi, M., Sadeghipour, P., Basaglia, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., Colaizzo, D., Dentali, F., Di Micco, P., Grandone, E., Imbalzano, E., Merla, S., Pesavento, R., Prandoni, P., Scarinzi, P., Siniscalchi, C., Taflaj, B., Tufano, A., Visonà, A., Vo Hong, N., Zalunardo, B., Fonseca, S., Manuel, M., Meireles, J., Bosevski, M., Eftimova, A., Zdraveska, M., Bounameaux, H., Mazzolai, L., Aujayeb, A., Caprini, J.A., Weinberg, I., Bui, H.M., Demelo-Rodriguez, Pablo, Alonso-Beato, Rubén, Jara-Palomares, Luis, Galeano-Valle, Francisco, Bura-Riviere, Alessandra, Visonà, Adriana, Francisco, Iria, Vidal, Gemma, López-Ruiz, Antonio, and Monreal, Manuel

Published
2023
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4. Venous thromboembolism characteristics, treatment and outcomes in young adults: findings from the Registro Informatizado de Enfermedad TromboEmbólica registry

Author

Monreal, Manuel, Prandoni, Paolo, Brenner, Benjamin, Farge-Bancel, Dominique, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Schellong, Sebastian, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Verhamme, Peter, Caprini, Joseph A., Bui, Hanh My, Adarraga, M.D., Alberich-Conesa, A., Alonso-Carrillo, J., Amado, C., Amorós, S., Arcelus, J.I., Ballaz, A., Barba, R., Barbagelata, C., Barrón, M., Barrón-Andrés, B., Blanco-Molina, A., Botella, E., Casado, I., Chasco, L., Cerdà, P., Criado, J., del Toro, J., De Juana-Izquierdo, C., Demelo-Rodríguez, P., Díaz-Brasero, A.M., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Dubois-Silva, A., Escribano, J.C., Espósito, F., Falgá, C., Fernández-Capitán, C., Fernández-Jiménez, B., Fernández-Muixi, J., Fernández-Reyes, J.L., Fidalgo, M.A., Font, C., Francisco, I., Galeano-Valle, F., García, M.A., García de Herreros, M., García-Bragado, F., García-Ortega, A., Gavín-Sebastián, O., Gil-Díaz, A., Gómez-Cuervo, C., Gómez-Mosquera, A.M., González-Martínez, J., González-Moreno, M., Grau, E., Guirado, L., Gutiérrez, J., Hernández-Blasco, L., Jaras, M.J., Jiménez, D., Jou, I., Joya, M.D., Lacruz, B., Lainez-Justo, S., Lalueza, A., Latorre, A., Lecumberri, R., Lobo, J.L., López-De la Fuente, M., López-Jiménez, L., López-Miguel, P., López-Núñez, J.J., López-Ruiz, A., López-Sáez, J.B., Lorenzo, A., Lumbierres, M., Madridano, O., Maestre, A., Marcos, M., Martín-Martos, F., Mellado, M., Mena, E., Mercado, M.I., Moisés, J., Monreal, M., Muñoz-Blanco, A., Muñoz-Gamito, G., Morales, M.V., Nieto, J.A., Noguera-Gras, E., Núñez-Fernández, M.J., Osorio, J., Otalora, S., Pacheco-Gómez, N., Paredes-Ruiz, D., Parra, P., Pedrajas, J.M., Pérez-Ductor, C., Pérez-Jacoiste, M.A., Pérez-Pérez, J.L., Peris, M.L., Porras, J.A., Poyo-Molina, J., Puchades, R., Riera-Mestre, A., Rivera-Civico, F., Rivera-Gallego, A., Roca, M., Rosa, V., Rodríguez-Cobo, A., Ruiz-Giménez, N., Salgueiro, G., Sancho, T., Sendín, V., Sigüenza, P., Soler, S., Suriñach, J.M., Tiberio, G., Torres, M.I., Trujillo-Santos, J., Uresandi, F., Usandizaga, E., Valle, R., Varona, J.F., Vela, L., Vela, J.R., Villalobos, A., Villares, P., Ay, C., Nopp, S., Pabinger, I., Engelen, M.M., Martens, C., Verhamme, P., Yoo, H.H.B., Arguello, J.D., Montenegro, A.C., Roa, J., Hirmerova, J., Malý, R., Accassat, S., Bertoletti, L., Bura-Riviere, A., Catella, J., Chopard, R., Couturaud, F., Espitia, O., Leclercq, B., Le Mao, R., Mahé, I., Moustafa, F., Plaisance, L., Poenou, G., Sarlon-Bartoli, G., Suchon, P., Versini, E., Schellong, S., Braester, A., Brenner, B., Kenet, G., Tzoran, I., Sadeghipour, P., Basaglia, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., Colaizzo, D., De Angelis, A., Dentali, F., Di Micco, P., Grandone, E., Imbalzano, E., Merla, S., Pesavento, R., Prandoni, P., Scarinzi, P., Siniscalchi, C., Tufano, A., Visonà, A., Vo Hong, N., Zalunardo, B., Gibietis, V., Kigitovica, D., Skride, A., Fonseca, S., Manuel, M., Meireles, J., Bosevski, M., Bounameaux, H., Mazzolai, L., Aujayeb, A., Caprini, J.A., Weinberg, I., Bui, H.M., Cohen, Omri, Barg, Assaf A., Nowak-Göttl, Ulrike, Amado-Fernández, Cristina, Mazzolai, Lucia, Tiberio, Gregorio, Skride, Andris, Morales, María del Valle, and Kenet, Gili

Published
2023
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5. Enoxaparin versus dalteparin or tinzaparin in patients with cancer and venous thromboembolism: The RIETECAT study

Author

Trujillo‐Santos, Javier, Farge‐Bancel, Dominique, Pedrajas, José María, Gómez‐Cuervo, Covadonga, Ballaz, Aitor, Braester, Andrei, Mahé, Isabelle, Villalobos, Aurora, Porras, José Antonio, Monreal, Manuel, Adarraga, MD, Aibar, J, Aibar, MA, Amado, C, Arcelus, JI, Asuero, A, Barba, R, Barbagelata, C, Barrón, M, Barrón‐Andrés, B, Blanco‐Molina, A, Botella, E, Camon, AM, Casado, I, Castro, J, Castro, M, Chasco, L, Criado, J, de Ancos, C, del Toro, J, Demelo‐Rodríguez, P, Díaz‐Brasero, AM, Díaz‐Peromingo, JA, Di Campli, MV, Dubois‐Silva, A, Escribano, JC, Espósito, F, Falgá, C, Farfán‐Sedano, AI, Fernández‐Capitán, C, Fernández‐Reyes, JL, Fidalgo, MA, Flores, K, Font, C, Font, L, Francisco, I, Gabara, C, Galeano‐Valle, F, García, MA, García‐Bragado, F, García de Herreros, M, García de la Garza, R, García‐Díaz, C, García‐Hernáez, R, García‐Raso, A, Gil‐Díaz, A, Giménez‐Suau, M, Grau, E, Guirado, L, Gutiérrez, J, Hernández‐Blasco, L, Hernando, E, Jara‐Palomares, L, Jaras, MJ, Jiménez, D, Jiménez, R, Jiménez‐Alfaro, C, Joya, MD, Lainez‐Justo, S, Latorre, A, Lima, J, Llamas, P, Lobo, JL, López‐Jiménez, L, López‐Miguel, P, López‐Núñez, JJ, López‐Reyes, R, López‐Sáez, JB, Lorenzo, A, Madridano, O, Maestre, A, Marchena, PJ, Martín‐Martos, F, Martínez‐Urbistondo, D, Mella, C, Mercado, MI, Moisés, J, Morales, MV, Muñoz‐Blanco, A, Muñoz‐Rivas, N, Navas, MS, Nieto, JA, Nofuentes‐Pérez, E, Núñez‐Fernández, MJ, Obispo, B, Olid, M, Olivares, MC, Orcastegui, JL, Osorio, J, Otalora, S, Otero, R, Paredes, D, Parra, P, Pellejero, G, Portillo, J, Rivera‐Civico, F, Rodríguez‐Chiaradía, DA, Rodríguez‐Matute, C, Rogado, J, Rosa, V, Ruiz‐Artacho, P, Ruiz‐Giménez, N, Ruiz‐Ruiz, J, Ruiz‐Sada, P, Salgueiro, G, Sánchez‐Martínez, R, Sánchez‐Muñoz‐Torrero, JF, Sancho, T, Soler, S, Suárez‐Rodríguez, B, Suriñach, JM, Tirado, R, Torres, MI, Tolosa, C, Uresandi, F, Valero, B, Valle, R, Varona, JF, Vidal, G, Villares, P, Zamora, C, Engelen, M, Vanassche, T, Verhamme, P, Hirmerova, J, Malý, R, Ait Abdallah, N, Bertoletti, L, Bura‐Riviere, A, Catella, J, Couturaud, F, Crichi, B, Debourdeau, P, Espitia, O, Falvo, N, Helfer, H, Lacut, K, Le Mao, R, Moustafa, F, Poenou, G, Quere, I, Schellong, S, Brenner, B, Tzoran, I, Nikandish, R, Bilora, F, Brandolin, B, Ciammaichella, M, Di Micco, P, Imbalzano, E, Maida, R, Pace, F, Pesavento, R, Prandoni, P, Quintavalla, R, Rocci, A, Siniscalchi, C, Tufano, A, Visonà, A, Zalunardo, B, Birzulis, J, Skride, A, Zaicenko, A, Fonseca, S, Martins, F, Meireles, J, Bosevski, M, Bounameaux, H, Mazzolai, L, Ochoa‐Chaar, CI, Weinberg, I, and Bui, HM

Published
2022
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6. Age-Related Differences in the Presentation, Management, and Clinical Outcomes of 100,000 Patients With Venous Thromboembolism in the RIETE Registry

Author

Ortega, Alberto García, primary, Jiménez, David, additional, Pedro-Tudela, Ana, additional, Pérez-Ductor, Cristina, additional, Fernández-Capitán, Carmen, additional, Falgá, Conxita, additional, Skride, Andris, additional, Siniscalchi, Carmine, additional, Weinberg, Ido, additional, Monreal, Manuel, additional, Adarraga, M.D., additional, Alberich-Conesa, A., additional, Aibar, J., additional, Alda-Lozano, A., additional, Alfonso, J., additional, Amado, C., additional, Angelina-García, M., additional, Arcelus, J.I., additional, Ballaz, A., additional, Barba, R., additional, Barbagelata, C., additional, Barrón, M., additional, Barrón-Andrés, B., additional, Bascuñana, J., additional, Beddar-Chaib, F., additional, Blanco-Molina, A., additional, Caballero, J.C., additional, Castellanos, G., additional, Chasco, L., additional, Criado, J., additional, De Ancos, C., additional, Del Toro, J., additional, Demelo-Rodríguez, P., additional, De Juana-Izquierdo, C., additional, Díaz-Brasero, A.M., additional, Díaz-Peromingo, J.A., additional, Dubois-Silva, A., additional, Escribano, J.C., additional, Falgá, C., additional, Farfán-Sedano, A.I., additional, Fernández-Aracil, C., additional, Fernández-Capitán, C., additional, Fernández-Jiménez, B., additional, Fernández-Reyes, J.L., additional, Fidalgo, M.A., additional, Francisco, I., additional, Gabara, C., additional, Galeano-Valle, F., additional, García-Bragado, F., additional, García-Ortega, A., additional, Gavín-Sebastián, O., additional, Gil De Gómez, M.A., additional, Gil-Díaz, A., additional, Gómez-Cuervo, C., additional, González-Munera, A., additional, Grau, E., additional, Guirado, L., additional, Gutiérrez, J., additional, Hernández-Blasco, L., additional, Jara-Palomares, L., additional, Jaras, M.J., additional, Jiménez, D., additional, Jiménez, R., additional, Jou, I., additional, Joya, M.D., additional, Lainez-Justo, S., additional, Lecumberri, R., additional, León-Ramírez, J.M., additional, Llamas, P., additional, Lobo, J.L., additional, López-Jiménez, L., additional, López-Miguel, P., additional, López-Núñez, J.J., additional, López-Ruiz, A., additional, López-Sáez, J.B., additional, Lorenzo, A., additional, Lumbierres, M., additional, Madridano, O., additional, Maestre, A., additional, Marchena, P.J., additional, Marcos, M., additional, Martín del Pozo, M., additional, Martín-Martos, F., additional, Maza, J.M., additional, Mena, E., additional, Mercado, M.I., additional, Moisés, J., additional, Monreal, M., additional, Morales, M.V., additional, Navas, M.S., additional, Nieto, J.A., additional, Núñez-Fernández, M.J., additional, Olid, M., additional, Ordieres-Ortega, L., additional, Ortiz, M., additional, Osorio, J., additional, Otálora, S., additional, Otero, R., additional, Pacheco-Gómez, N., additional, Pagán, J., additional, Palomeque, A.C., additional, Paredes, E., additional, Parra-Caballero, P., additional, Parra-Rosado, P., additional, Pedrajas, J.M., additional, Pérez-Ductor, C., additional, Pérez-Pinar, M., additional, Peris, M.L., additional, Pesce, M.L., additional, Porras, J.A., additional, Puchades, R., additional, Rivera-Cívico, F., additional, Rodríguez-Cobo, A., additional, Rosa, V., additional, Romero-Brugera, M., additional, Ruiz-Artacho, P., additional, Ruiz-Giménez, N., additional, Ruiz-Ruiz, J., additional, Salgueiro, G., additional, Sancho, T., additional, Sendín, V., additional, Sigüenza, P., additional, Soler, S., additional, Suárez-Fernández, S., additional, Tirado, R., additional, Torrents-Vilar, A., additional, Torres, M.I., additional, Trujillo-Santos, J., additional, Uresandi, F., additional, Valle, R., additional, Varona, J.F., additional, Villalobos, A., additional, Villares, P., additional, Ay, C., additional, Nopp, S., additional, Pabinger, I., additional, Vanassche, T., additional, Verhamme, P., additional, Verstraete, A., additional, Yoo, H.H.B., additional, Montenegro, A.C., additional, Morales, S.N., additional, Roa, J., additional, Hirmerova, J., additional, Malý, R., additional, Bertoletti, L., additional, Bura-Riviere, A., additional, Catella, J., additional, Chopard, R., additional, Couturaud, F., additional, Espitia, O., additional, Grange, C., additional, Leclercq, B., additional, Le Mao, R., additional, Mahé, I., additional, Moustafa, F., additional, Plaisance, L., additional, Sarlon-Bartoli, G., additional, Suchon, P., additional, Versini, E., additional, Schellong, S., additional, Brenner, B., additional, Dally, N., additional, Tzoran, I., additional, Sadeghipour, P., additional, Rashidi, F., additional, Abenante, A., additional, Barillari, G., additional, Basaglia, M., additional, Bilora, F., additional, Bissacco, D., additional, Bortoluzzi, C., additional, Brandolin, B., additional, Casana, R., additional, Ciammaichella, M., additional, Colaizzo, D., additional, Dentali, F., additional, Di Micco, P., additional, Grandone, E., additional, Imbalzano, E., additional, Lambertenghi-Deliliers, D., additional, Negro, F., additional, Pesavento, R., additional, Poz, A., additional, Prandoni, P., additional, Scarinzi, P., additional, Siniscalchi, C., additional, Taflaj, B., additional, Tufano, A., additional, Visonà, A., additional, Vo Hong, N., additional, Zalunardo, B., additional, Paluga, R., additional, Skride, A., additional, Kigitovica, D., additional, Fonseca, S., additional, Marques, R., additional, Meireles, J., additional, Pinto, S., additional, Bosevski, M., additional, Trajkova, M., additional, Zdraveska, M., additional, Bounameaux, H., additional, Mazzolai, L., additional, Aujayeb, A., additional, Caprini, J.A., additional, Weinberg, I., additional, and Bui, H.M., additional

Published
2024
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7. A prognostic score to identify women at increased risk for abnormal uterine bleeding during anticoagulation for venous thromboembolism

Author

Sarlon-Bartoli, Gabrielle, primary, Criado, Juan, additional, Middeldorp, Saskia, additional, Nieto, José Antonio, additional, Díaz-Pedroche, María del Carmen, additional, Moustafa, Farès, additional, Ruiz-Giménez, Nuria, additional, Brenner, Benjamin, additional, Monreal, Manuel, additional, DI Micco, Pierpaolo, additional, Prandoni, Paolo, additional, Farge-Bancel, Dominique, additional, Barba, Raquel, additional, Di Micco, Pierpaolo, additional, Bertoletti, Laurent, additional, Schellong, Sebastian, additional, Tzoran, Inna, additional, Reis, Abilio, additional, Bosevski, Marijan, additional, Bounameaux, Henri, additional, Malý, Radovan, additional, Verhamme, Peter, additional, Caprini, Joseph A., additional, Bui, Hanh My, additional, Adarraga, M.D., additional, Agudo, P., additional, Amado, C., additional, Arcelus, J.I., additional, Ballaz, A., additional, Bascuñana, J., additional, Barba, R., additional, Barbagelata, C., additional, Barrón, M., additional, Barrón-Andrés, B., additional, Blanco-Molina, A., additional, Beddar Chaib, F., additional, Botella, E., additional, Cañas, I., additional, Carrero-Arribas, R., additional, Casado, I., additional, Cerdá, P., additional, Chasco, L., additional, Criado, J., additional, de Ancos, C., additional, de Miguel, J., additional, del Toro, J., additional, Demelo-Rodríguez, P., additional, Díaz-Brasero, A.M., additional, Díaz-Pedroche, M.C., additional, Díaz-Peromingo, J.A., additional, Domínguez, I.M., additional, Dubois-Silva, A., additional, Escribano, J.C., additional, Espósito, F., additional, Farfán-Sedano, A.I., additional, Falgá, C., additional, Fernández-Capitán, C., additional, Fernández-Jiménez, B., additional, Fernández-Muixi, J., additional, Fernández-Reyes, J.L., additional, Font, C., additional, Francisco, I., additional, Galeano-Valle, F., additional, García, M.A., additional, García-Bragado, F., additional, García de Herreros, M., additional, Gavín-Blanco, O., additional, Gil-Díaz, A., additional, Gómez-Cuervo, C., additional, Gómez-Mosquera, A.M., additional, Gonzalez-Moreno, M., additional, Grau, E., additional, Guirado, L., additional, Gutiérrez, J., additional, Hernández-Blasco, L., additional, Jara-Palomares, L., additional, Jaras, M.J., additional, Jiménez, D., additional, Jou, I., additional, Joya, M.D., additional, Lacruz, B., additional, Lainez-Justo, S., additional, A, Latorre, additional, J, Lima, additional, Jl, Lobo, additional, López-De la Fuente, M., additional, López-Jiménez, L., additional, López-Meseguer, M., additional, López-Miguel, P., additional, López-Núñez, J.J., additional, López-Reyes, R., additional, López-Sáez, J.B., additional, Lorente, M.A., additional, Lorenzo, A., additional, Madridano, O., additional, Maestre, A., additional, Marchena, P.J., additional, Martín-Guerra, J.M., additional, Martín-Martos, F., additional, Mellado, M., additional, Mena, E., additional, Moisés, J., additional, Mercado, M.I., additional, Monreal, M., additional, Muñoz-Blanco, A., additional, Muñoz-Gamito, G., additional, Morales, M.V., additional, Nieto, J.A., additional, Noguera-Gras, E., additional, Núñez-Fernández, M.J., additional, Olid-Velilla, M., additional, Osorio, J., additional, Otalora, S., additional, Otero, R., additional, Paredes-Ruiz, D., additional, Parra, P., additional, Parra, V., additional, Pedrajas, J.M., additional, Pérez-López, M., additional, Peris, M.L., additional, Pesce, M.L., additional, Porras, J.A., additional, Poyo-Molina, J., additional, Puchades, R., additional, Riera-Mestre, A., additional, Rivera-Civico, F., additional, Rivera-Gallego, A., additional, Roca, M., additional, Rosa, V., additional, Rodríguez-Cobo, A., additional, Rodríguez-Matute, C., additional, Ruiz-Artacho, P., additional, Ruiz-Giménez, N., additional, Ruiz-Ruiz, J., additional, Salgueiro, G., additional, Sancho, T., additional, Sendín, V., additional, Sigüenza, P., additional, Soler, S., additional, Suárez-Rodríguez, B., additional, Suriñach, J.M., additional, Tiberio, G., additional, Torres, M.I., additional, Torres-Sánchez, A., additional, Trujillo-Santos, J., additional, Uresandi, F., additional, Usandizaga, E., additional, Valle, R., additional, Varona, J.F., additional, Vela, L., additional, Vela, J.R., additional, Villalobos, A., additional, Villares, P., additional, Ay, C., additional, Nopp, S., additional, Pabinger, I., additional, Engelen, M.M., additional, Martens, C., additional, Verhamme, P., additional, Yoo, H.H.B., additional, Arguello, J.D., additional, Montenegro, A.C., additional, Roa, J., additional, Hirmerova, J., additional, Malý, R., additional, Accassat, S., additional, Bertoletti, L., additional, Bura-Riviere, A., additional, Catella, J., additional, Chopard, R., additional, Couturaud, F., additional, Espitia, O., additional, El Harake, S., additional, Le Mao, R., additional, Mahé, I., additional, Moustafa, F., additional, Plaisance, L., additional, Sarlon-Bartoli, G., additional, Suchon, P., additional, Versini, E., additional, Schellong, S., additional, Braester, A., additional, Brenner, B., additional, Kenet, G., additional, Tzoran, I., additional, Sadeghipour, P., additional, Basaglia, M., additional, Bilora, F., additional, Bortoluzzi, C., additional, Brandolin, B., additional, Ciammaichella, M., additional, De Angelis, A., additional, Dentali, F., additional, Di Micco, P., additional, Imbalzano, E., additional, Merla, S., additional, Pesavento, R., additional, Prandoni, P., additional, Siniscalchi, C., additional, Tufano, A., additional, Visonà, A., additional, Vo Hong, N., additional, Zalunardo, B., additional, Kigitovica, D., additional, Rusa, E., additional, Skride, A., additional, Fonseca, S., additional, Manuel, M., additional, Meireles, J., additional, Bosevski, M., additional, Eftimova, A., additional, Zdraveska, M., additional, Bounameaux, H., additional, Mazzolai, L., additional, Aujayeb, A., additional, Caprini, J.A., additional, Weinberg, I., additional, and Bui, H.M., additional

Published
2023
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8. Venous thromboembolism characteristics, treatment and outcomes in young adults: findings from the Registro Informatizado de Enfermedad TromboEmbólica registry

Author

Cohen, Omri, primary, Barg, Assaf A., additional, Nowak-Göttl, Ulrike, additional, Amado-Fernández, Cristina, additional, Mazzolai, Lucia, additional, Tiberio, Gregorio, additional, Schellong, Sebastian, additional, Skride, Andris, additional, Morales, María del Valle, additional, Monreal, Manuel, additional, Kenet, Gili, additional, Prandoni, Paolo, additional, Brenner, Benjamin, additional, Farge-Bancel, Dominique, additional, Barba, Raquel, additional, Di Micco, Pierpaolo, additional, Bertoletti, Laurent, additional, Tzoran, Inna, additional, Reis, Abilio, additional, Bosevski, Marijan, additional, Bounameaux, Henri, additional, Malý, Radovan, additional, Verhamme, Peter, additional, Caprini, Joseph A., additional, Bui, Hanh My, additional, Adarraga, M.D., additional, Alberich-Conesa, A., additional, Alonso-Carrillo, J., additional, Amado, C., additional, Amorós, S., additional, Arcelus, J.I., additional, Ballaz, A., additional, Barba, R., additional, Barbagelata, C., additional, Barrón, M., additional, Barrón-Andrés, B., additional, Blanco-Molina, A., additional, Botella, E., additional, Casado, I., additional, Chasco, L., additional, Cerdà, P., additional, Criado, J., additional, del Toro, J., additional, De Juana-Izquierdo, C., additional, Demelo-Rodríguez, P., additional, Díaz-Brasero, A.M., additional, Díaz-Pedroche, M.C., additional, Díaz-Peromingo, J.A., additional, Dubois-Silva, A., additional, Escribano, J.C., additional, Espósito, F., additional, Falgá, C., additional, Fernández-Capitán, C., additional, Fernández-Jiménez, B., additional, Fernández-Muixi, J., additional, Fernández-Reyes, J.L., additional, Fidalgo, M.A., additional, Font, C., additional, Francisco, I., additional, Galeano-Valle, F., additional, García, M.A., additional, García de Herreros, M., additional, García-Bragado, F., additional, García-Ortega, A., additional, Gavín-Sebastián, O., additional, Gil-Díaz, A., additional, Gómez-Cuervo, C., additional, Gómez-Mosquera, A.M., additional, González-Martínez, J., additional, González-Moreno, M., additional, Grau, E., additional, Guirado, L., additional, Gutiérrez, J., additional, Hernández-Blasco, L., additional, Jaras, M.J., additional, Jiménez, D., additional, Jou, I., additional, Joya, M.D., additional, Lacruz, B., additional, Lainez-Justo, S., additional, Lalueza, A., additional, Latorre, A., additional, Lecumberri, R., additional, Lobo, J.L., additional, López-De la Fuente, M., additional, López-Jiménez, L., additional, López-Miguel, P., additional, López-Núñez, J.J., additional, López-Ruiz, A., additional, López-Sáez, J.B., additional, Lorenzo, A., additional, Lumbierres, M., additional, Madridano, O., additional, Maestre, A., additional, Marcos, M., additional, Martín-Martos, F., additional, Mellado, M., additional, Mena, E., additional, Mercado, M.I., additional, Moisés, J., additional, Monreal, M., additional, Muñoz-Blanco, A., additional, Muñoz-Gamito, G., additional, Morales, M.V., additional, Nieto, J.A., additional, Noguera-Gras, E., additional, Núñez-Fernández, M.J., additional, Osorio, J., additional, Otalora, S., additional, Pacheco-Gómez, N., additional, Paredes-Ruiz, D., additional, Parra, P., additional, Pedrajas, J.M., additional, Pérez-Ductor, C., additional, Pérez-Jacoiste, M.A., additional, Pérez-Pérez, J.L., additional, Peris, M.L., additional, Porras, J.A., additional, Poyo-Molina, J., additional, Puchades, R., additional, Riera-Mestre, A., additional, Rivera-Civico, F., additional, Rivera-Gallego, A., additional, Roca, M., additional, Rosa, V., additional, Rodríguez-Cobo, A., additional, Ruiz-Giménez, N., additional, Salgueiro, G., additional, Sancho, T., additional, Sendín, V., additional, Sigüenza, P., additional, Soler, S., additional, Suriñach, J.M., additional, Tiberio, G., additional, Torres, M.I., additional, Trujillo-Santos, J., additional, Uresandi, F., additional, Usandizaga, E., additional, Valle, R., additional, Varona, J.F., additional, Vela, L., additional, Vela, J.R., additional, Villalobos, A., additional, Villares, P., additional, Ay, C., additional, Nopp, S., additional, Pabinger, I., additional, Engelen, M.M., additional, Martens, C., additional, Verhamme, P., additional, Yoo, H.H.B., additional, Arguello, J.D., additional, Montenegro, A.C., additional, Roa, J., additional, Hirmerova, J., additional, Malý, R., additional, Accassat, S., additional, Bertoletti, L., additional, Bura-Riviere, A., additional, Catella, J., additional, Chopard, R., additional, Couturaud, F., additional, Espitia, O., additional, Leclercq, B., additional, Le Mao, R., additional, Mahé, I., additional, Moustafa, F., additional, Plaisance, L., additional, Poenou, G., additional, Sarlon-Bartoli, G., additional, Suchon, P., additional, Versini, E., additional, Schellong, S., additional, Braester, A., additional, Brenner, B., additional, Kenet, G., additional, Tzoran, I., additional, Sadeghipour, P., additional, Basaglia, M., additional, Bilora, F., additional, Bortoluzzi, C., additional, Brandolin, B., additional, Ciammaichella, M., additional, Colaizzo, D., additional, De Angelis, A., additional, Dentali, F., additional, Di Micco, P., additional, Grandone, E., additional, Imbalzano, E., additional, Merla, S., additional, Pesavento, R., additional, Prandoni, P., additional, Scarinzi, P., additional, Siniscalchi, C., additional, Tufano, A., additional, Visonà, A., additional, Vo Hong, N., additional, Zalunardo, B., additional, Gibietis, V., additional, Kigitovica, D., additional, Skride, A., additional, Fonseca, S., additional, Manuel, M., additional, Meireles, J., additional, Bosevski, M., additional, Bounameaux, H., additional, Mazzolai, L., additional, Aujayeb, A., additional, Caprini, J.A., additional, Weinberg, I., additional, and Bui, H.M., additional

Published
2023
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9. Bleeding risk in hospitalized patients with COVID‐19 receiving intermediate‐ or therapeutic doses of thromboprophylaxis

Author

Pablo Demelo‐Rodriguez, Ana Isabel Farfán‐Sedano, José María Pedrajas, Pilar Llamas, Patricia Sigüenza, María Jesús Jaras, Manuel Quintana‐Diaz, Carmen Fernández‐Capitán, Behnood Bikdeli, David Jiménez, Manuel Monreal, Adarraga D, Aibar J, Baeza C, Ballaz A, Barba R, Blanco‐Molina A, Botella E, Criado J, Demelo‐Rodríguez P, Díaz‐Brasero AM, de Ancos C, del Toro J, Farfán‐Sedano AI, Fernández‐Capitán C, Fidalgo A, Flores K, Gabara C, Galeano‐Valle F, Gavín‐Sebastián O, Gil‐Díaz A, Jaras MJ, Jara‐Palomares L, Jiménez R, Lainez‐Justo S, Latorre A, Lecumberri R, Llamas P, Lobo JL, López‐Jiménez L, Loureiro B, Madridano O, Mancebo‐Plaza AB, Martín del Pozo M, Monreal M, Muñoz‐Rivas N, Núñez‐Fernández MJ, Olivera PE, Ordieres‐Ortega L, Padín‐Paz EM, Pedrajas JM, Quintana‐Díaz M, Ríos‐Prego M, Rodríguez‐Chiaradía DA, Ruiz‐Artacho P, Sigüenza P, Suriñach JM, Trujillo‐Santos J, Zamora C, Bucherini E, Di Micco P, Imbalzano E, Siniscalchi C, Bosevski M, Stevanovic M, Paz‐Rios L, and Weinberg I

Subjects
anticoagulants, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Hospitalized patients, 030204 cardiovascular system & hematology, Logistic regression, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, COVID‐19, death, Internal medicine, medicine, Humans, Retrospective Studies, SARS-CoV-2, business.industry, Mortality rate, Incidence (epidemiology), Hazard ratio, COVID-19, Venous Thromboembolism, Original Articles, Hematology, Confidence interval, Original Article, prognosis, hemorrhage, business, Cohort study
Abstract

Introduction Some local protocols suggest using intermediate or therapeutic doses of anticoagulants for thromboprophylaxis in hospitalized patients with coronavirus disease 2019 (COVID‐19). However, the incidence of bleeding, predictors of major bleeding, or the association between bleeding and mortality remain largely unknown. Methods We performed a cohort study of patients hospitalized for COVID‐19 that received intermediate or therapeutic doses of anticoagulants from March 25 to July 22, 2020, to identify those at increased risk for major bleeding. We used bivariate and multivariable logistic regression to explore the risk factors associated with major bleeding. Results During the study period, 1965 patients were enrolled. Of them, 1347 (69%) received intermediate‐ and 618 (31%) therapeutic‐dose anticoagulation, with a median duration of 12 days in both groups. During the hospital stay, 112 patients (5.7%) developed major bleeding and 132 (6.7%) had non‐major bleeding. The 30‐day all‐cause mortality rate for major bleeding was 45% (95% confidence interval [CI]: 36%‐54%) and for non‐major bleeding 32% (95% CI: 24%‐40%). Multivariable analysis showed increased risk for in‐hospital major bleeding associated with D‐dimer levels >10 times the upper normal range (hazard ratio [HR], 2.23; 95% CI, 1.38–3.59), ferritin levels >500 ng/ml (HR, 2.01; 95% CI, 1.02–3.95), critical illness (HR, 1.91; 95% CI, 1.14–3.18), and therapeutic‐intensity anticoagulation (HR, 1.43; 95% CI, 1.01–1.97). Conclusions Among patients hospitalized with COVID‐19 receiving intermediate‐ or therapeutic‐intensity anticoagulation, a major bleeding event occurred in 5.7%. Use of therapeutic‐intensity anticoagulation, critical illness, and elevated D‐dimer or ferritin levels at admission were associated with increased risk for major bleeding.

Published
2021
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10. Liver status and outcomes in patients without previous known liver disease receiving anticoagulant therapy for venous thromboembolism

Author

Martinez-Urbistondo D., de la Garza R. G., Villares-Fernandez P., Font C., Schellong S., Lopez-Nunez J. J., Gil-Diaz A., del Carmen Diaz-Pedroche M., Hirmerova J., Monreal M., Adarraga M., Aibar J., Alonso J., Amado C., Arcelus J., Asuero A., Ballaz A., Barba R., Barbagelata C., Barron M., Barron-Andres B., Blanco-Molina A., Beddar Chaib F., Botella E., Castro J., Chasco L., Criado J., de Ancos C., del Toro J., Demelo-Rodriguez P., Diaz-Brasero A., Diaz-Pedroche M., Diaz-Peromingo J., Di Campli M., Dubois-Silva A., Escribano J., Esposito F., Farfan-Sedano A., Fernandez-Capitan C., Fernandez-Reyes J., Fidalgo M., Flores K., Font L., Francisco I., Gabara C., Galeano-Valle F., Garcia M., Garcia-Bragado F., Garcia de Herreros M., de la Garza R., Garcia-Diaz C., Gomez-Cuervo C., Grau E., Guirado L., Gutierrez J., Hernandez-Blasco L., Jara-Palomares L., Jaras M., Jimenez D., Jimenez R., Jimenez-Alfaro C., Joya M., Lainez-Justo S., Lalueza A., Latorre A., Lima J., Lobo J., Lopez-Jimenez L., Lopez-Miguel P., Lopez-Nunez J., Lopez-Reyes R., Lopez-Saez J., Lorenzo A., Madridano O., Maestre A., Marchena P., Martin del Pozo M., Martin-Martos F., Mella C., Mercado M., Moises J., Munoz-Blanco A., Nieto J., Nofuentes-Perez E., Nunez-Fernandez M., Olid-Velilla M., Olivares M., Osorio J., Otalora S., Otero R., Paredes D., Pedrajas J., Porras J., Portillo J., Redondo I., Rodriguez-Matute C., Rosa V., Ruiz-Artacho P., Ruiz-Ruiz J., Salgueiro G., Sanchez-Martinez R., Sanchez-Munoz-Torrero J., Sancho T., Soler S., Suarez-Rodriguez B., Surinach J., Torres M., Torres-Sanchez A., Tolosa C., Trujillo-Santos J., Uresandi F., Valero B., Valle R., Varona J., Vela L., Vela J., Vidal G., Villalobos A., Villares P., Zamora C., Ay C., Nopp S., Pabinger I., Engelen M., Vanassche T., Verhamme P., Maly R., Accassat S., Ait Abdallah N., Bertoletti L., Bura-Riviere A., Catella J., Couturaud F., Crichi B., Debourdeau P., Espitia O., Farge-Bancel D., Grange C., Helfer H., Lacut K., Le Mao R., Mahe I., Morange P., Moustafa F., Poenou G., Sarlon-Bartoli G., Suchon P., Quere I., Braester A., Brenner B., Kenet G., Tzoran I., Basaglia M., Bilora F., Bortoluzzi C., Brandolin B., Ciammaichella M., De Angelis A., Di Micco P., Imbalzano E., Merla S., Pesavento R., Prandoni P., Siniscalchi C., Tufano A., Visona A., Vo Hong N., Zalunardo B., Nishimoto Y., Sato Y., Make K., Skride A., Strautmane S., Fonseca S., Martins F., Meireles J., Bosevski M., Bounameaux H., Mazzolai L., Caprini J., Bui H., Martinez-Urbistondo, D., de la Garza, R. G., Villares-Fernandez, P., Font, C., Schellong, S., Lopez-Nunez, J. J., Gil-Diaz, A., del Carmen Diaz-Pedroche, M., Hirmerova, J., Monreal, M., Adarraga, M., Aibar, J., Alonso, J., Amado, C., Arcelus, J., Asuero, A., Ballaz, A., Barba, R., Barbagelata, C., Barron, M., Barron-Andres, B., Blanco-Molina, A., Beddar Chaib, F., Botella, E., Castro, J., Chasco, L., Criado, J., de Ancos, C., del Toro, J., Demelo-Rodriguez, P., Diaz-Brasero, A., Diaz-Pedroche, M., Diaz-Peromingo, J., Di Campli, M., Dubois-Silva, A., Escribano, J., Esposito, F., Farfan-Sedano, A., Fernandez-Capitan, C., Fernandez-Reyes, J., Fidalgo, M., Flores, K., Font, L., Francisco, I., Gabara, C., Galeano-Valle, F., Garcia, M., Garcia-Bragado, F., Garcia de Herreros, M., de la Garza, R., Garcia-Diaz, C., Gomez-Cuervo, C., Grau, E., Guirado, L., Gutierrez, J., Hernandez-Blasco, L., Jara-Palomares, L., Jaras, M., Jimenez, D., Jimenez, R., Jimenez-Alfaro, C., Joya, M., Lainez-Justo, S., Lalueza, A., Latorre, A., Lima, J., Lobo, J., Lopez-Jimenez, L., Lopez-Miguel, P., Lopez-Nunez, J., Lopez-Reyes, R., Lopez-Saez, J., Lorenzo, A., Madridano, O., Maestre, A., Marchena, P., Martin del Pozo, M., Martin-Martos, F., Mella, C., Mercado, M., Moises, J., Munoz-Blanco, A., Nieto, J., Nofuentes-Perez, E., Nunez-Fernandez, M., Olid-Velilla, M., Olivares, M., Osorio, J., Otalora, S., Otero, R., Paredes, D., Pedrajas, J., Porras, J., Portillo, J., Redondo, I., Rodriguez-Matute, C., Rosa, V., Ruiz-Artacho, P., Ruiz-Ruiz, J., Salgueiro, G., Sanchez-Martinez, R., Sanchez-Munoz-Torrero, J., Sancho, T., Soler, S., Suarez-Rodriguez, B., Surinach, J., Torres, M., Torres-Sanchez, A., Tolosa, C., Trujillo-Santos, J., Uresandi, F., Valero, B., Valle, R., Varona, J., Vela, L., Vela, J., Vidal, G., Villalobos, A., Villares, P., Zamora, C., Ay, C., Nopp, S., Pabinger, I., Engelen, M., Vanassche, T., Verhamme, P., Maly, R., Accassat, S., Ait Abdallah, N., Bertoletti, L., Bura-Riviere, A., Catella, J., Couturaud, F., Crichi, B., Debourdeau, P., Espitia, O., Farge-Bancel, D., Grange, C., Helfer, H., Lacut, K., Le Mao, R., Mahe, I., Morange, P., Moustafa, F., Poenou, G., Sarlon-Bartoli, G., Suchon, P., Quere, I., Braester, A., Brenner, B., Kenet, G., Tzoran, I., Basaglia, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., De Angelis, A., Di Micco, P., Imbalzano, E., Merla, S., Pesavento, R., Prandoni, P., Siniscalchi, C., Tufano, A., Visona, A., Vo Hong, N., Zalunardo, B., Nishimoto, Y., Sato, Y., Make, K., Skride, A., Strautmane, S., Fonseca, S., Martins, F., Meireles, J., Bosevski, M., Bounameaux, H., Mazzolai, L., Caprini, J., and Bui, H.

Subjects
medicine.medical_specialty, VTE risk assessment, Healthy individual, Elevated liver enzymes, Hemorrhage, Gastroenterology, Liver disease, Recurrence, Fibrosis, Internal medicine, Internal Medicine, medicine, Anticoagulation adverse event, Humans, In patient, Registries, Clinical VTE, business.industry, Liver Diseases, Anticoagulants, Venous Thromboembolism, medicine.disease, Im - Original, Non-invasive liver assessment, Healthy individuals, Increased risk, Anticoagulant therapy, Emergency Medicine, Anticoagulation adverse events, business, Venous thromboembolism, Major bleeding
Abstract

The association between elevated liver enzymes or FIB-4 (fibrosis index 4) and outcome in patients with venous thromboembolism (VTE) has not been evaluated. Data from patients in RIETE (Registro Informatizado Enfermedad TromboEmbólica) were used to assess the association between elevated liver enzymes or FIB-4 levels and the rates of major bleeding or death in apparent liver disease-free patients with acute VTE under anticoagulation therapy. A total of 6206 patients with acute VTE and without liver disease were included. Of them, 92 patients had major bleeding and 168 died under anticoagulation therapy. On multivariable analysis, patients with elevated liver enzymes were at increased mortality risk (HR: 1.58; 95% CI: 1.10–2.28), while those with FIB-4 levels > 2.67 points were at increased risk for major bleeding (HR: 1.69; 95% CI: 1.04–2.74). Evaluation of liver enzymes and FIB-4 index at baseline in liver disease-free patients with VTE may provide additional information on the risk for major bleeding or death during anticoagulation. Supplementary Information The online version contains supplementary material available at 10.1007/s11739-021-02858-x.

Published
2021

11. Enoxaparin versus dalteparin or tinzaparin in patients with cancer and venous thromboembolism: The RIETECAT study

Author

Trujillo-Santos J, Farge-Bancel D, Pedrajas JM, Gómez-Cuervo C, Ballaz A, Braester A, Mahé I, Villalobos A, Porras JA, Monreal M, RIETE Investigators, M D Adarraga, J Aibar, M A Aibar, C Amado, J I Arcelus, A Asuero, R Barba, C Barbagelata, M Barrón, B Barrón-Andrés, A Blanco-Molina, E Botella, A M Camon, I Casado, J Castro, M Castro, L Chasco, J Criado, C de Ancos, J Del Toro, P Demelo-Rodríguez, A M Díaz-Brasero, J A Díaz-Peromingo, M V Di Campli, A Dubois-Silva, J C Escribano, F Espósito, C Falgá, A I Farfán-Sedano, C Fernández-Capitán, J L Fernández-Reyes, M A Fidalgo, K Flores, C Font, L Font, I Francisco, C Gabara, F Galeano-Valle, M A García, F García-Bragado, M García de Herreros, R García de la Garza, C García-Díaz, R García-Hernáez, A García-Raso, A Gil-Díaz, M Giménez-Suau, E Grau, L Guirado, J Gutiérrez, L Hernández-Blasco, E Hernando, L Jara-Palomares, M J Jaras, D Jiménez, R Jiménez, C Jiménez-Alfaro, M D Joya, S Lainez-Justo, A Latorre, J Lima, P Llamas, J L Lobo, L López-Jiménez, P López-Miguel, J J López-Núñez, R López-Reyes, J B López-Sáez, A Lorenzo, O Madridano, A Maestre, P J Marchena, F Martín-Martos, D Martínez-Urbistondo, C Mella, M I Mercado, J Moisés, M V Morales, A Muñoz-Blanco, N Muñoz-Rivas, M S Navas, J A Nieto, E Nofuentes-Pérez, M J Núñez-Fernández, B Obispo, M Olid, M C Olivares, J L Orcastegui, J Osorio, S Otalora, R Otero, D Paredes, P Parra, G Pellejero, J Portillo, F Rivera-Civico, D A Rodríguez-Chiaradía, C Rodríguez-Matute, J Rogado, V Rosa, P Ruiz-Artacho, N Ruiz-Giménez, J Ruiz-Ruiz, P Ruiz-Sada, G Salgueiro, R Sánchez-Martínez, J F Sánchez-Muñoz-Torrero, T Sancho, S Soler, B Suárez-Rodríguez, J M Suriñach, R Tirado, M I Torres, C Tolosa, F Uresandi, B Valero, R Valle, J F Varona, G Vidal, P Villares, C Zamora, M Engelen, T Vanassche, P Verhamme, J Hirmerova, R Malý, N Ait Abdallah, L Bertoletti, A Bura-Riviere, J Catella, F Couturaud, B Crichi, P Debourdeau, O Espitia, N Falvo, H Helfer, K Lacut, R Le Mao, F Moustafa, G Poenou, I Quere, S Schellong, B Brenner, I Tzoran, R Nikandish, F Bilora, B Brandolin, M Ciammaichella, P Di Micco, E Imbalzano, R Maida, F Pace, R Pesavento, P Prandoni, R Quintavalla, A Rocci, C Siniscalchi, A Tufano, A Visonà, B Zalunardo, J Birzulis, A Skride, A Zaicenko, S Fonseca, F Martins, J Meireles, M Bosevski, H Bounameaux, L Mazzolai, C I Ochoa-Chaar, I Weinberg, H M Bui, J, Trujillo-Santo, D, Farge-Bancel, Jm, Pedraja, C, Gómez-Cuervo, A, Ballaz, A, Braester, I, Mahé, A, Villalobo, Ja, Porra, M, Monreal, Investigators, Riete, D Adarraga, M, Aibar, J, A Aibar, M, Amado, C, I Arcelus, J, Asuero, A, Barba, R, Barbagelata, C, Barrón, M, Barrón-Andrés, B, Blanco-Molina, A, Botella, E, M Camon, A, Casado, I, Castro, J, Castro, M, Chasco, L, Criado, J, de Ancos, C, Del Toro, J, Demelo-Rodríguez, P, M Díaz-Brasero, A, A Díaz-Peromingo, J, V Di Campli, M, Dubois-Silva, A, C Escribano, J, Espósito, F, Falgá, C, I Farfán-Sedano, A, Fernández-Capitán, C, L Fernández-Reyes, J, A Fidalgo, M, Flores, K, Font, C, Font, L, Francisco, I, Gabara, C, Galeano-Valle, F, A García, M, García-Bragado, F, García de Herreros, M, García de la Garza, R, García-Díaz, C, García-Hernáez, R, García-Raso, A, Gil-Díaz, A, Giménez-Suau, M, Grau, E, Guirado, L, Gutiérrez, J, Hernández-Blasco, L, Hernando, E, Jara-Palomares, L, J Jaras, M, Jiménez, D, Jiménez, R, Jiménez-Alfaro, C, D Joya, M, Lainez-Justo, S, Latorre, A, Lima, J, Llamas, P, L Lobo, J, López-Jiménez, L, López-Miguel, P, J López-Núñez, J, López-Reyes, R, B López-Sáez, J, Lorenzo, A, Madridano, O, Maestre, A, J Marchena, P, Martín-Martos, F, Martínez-Urbistondo, D, Mella, C, I Mercado, M, Moisés, J, V Morales, M, Muñoz-Blanco, A, Muñoz-Rivas, N, S Navas, M, A Nieto, J, Nofuentes-Pérez, E, J Núñez-Fernández, M, Obispo, B, Olid, M, C Olivares, M, L Orcastegui, J, Osorio, J, Otalora, S, Otero, R, Paredes, D, Parra, P, Pellejero, G, Portillo, J, Rivera-Civico, F, A Rodríguez-Chiaradía, D, Rodríguez-Matute, C, Rogado, J, Rosa, V, Ruiz-Artacho, P, Ruiz-Giménez, N, Ruiz-Ruiz, J, Ruiz-Sada, P, Salgueiro, G, Sánchez-Martínez, R, F Sánchez-Muñoz-Torrero, J, Sancho, T, Soler, S, Suárez-Rodríguez, B, M Suriñach, J, Tirado, R, I Torres, M, Tolosa, C, Uresandi, F, Valero, B, Valle, R, F Varona, J, Vidal, G, Villares, P, Zamora, C, Engelen, M, Vanassche, T, Verhamme, P, Hirmerova, J, Malý, R, Ait Abdallah, N, Bertoletti, L, Bura-Riviere, A, Catella, J, Couturaud, F, Crichi, B, Debourdeau, P, Espitia, O, Falvo, N, Helfer, H, Lacut, K, Le Mao, R, Moustafa, F, Poenou, G, Quere, I, Schellong, S, Brenner, B, Tzoran, I, Nikandish, R, Bilora, F, Brandolin, B, Ciammaichella, M, Di Micco, P, Imbalzano, E, Maida, R, Pace, F, Pesavento, R, Prandoni, P, Quintavalla, R, Rocci, A, Siniscalchi, C, Tufano, A, Visonà, A, Zalunardo, B, Birzulis, J, Skride, A, Zaicenko, A, Fonseca, S, Martins, F, Meireles, J, Bosevski, M, Bounameaux, H, Mazzolai, L, I Ochoa-Chaar, C, Weinberg, I, and M Bui, H

Subjects
dalteparin, recurrences, tinzaparin, venous thromboembolism, cancer, enoxaparin, Hematology, cohort, LMWH
Abstract

Venous thromboembolism (VTE) is a frequent complication in patients with cancer and a leading cause of morbidity and death. The objective of the RIETECAT study was to compare the long-term effectiveness and safety of enoxaparin versus dalteparin or tinzaparin for the secondary prevention of VTE in adults with active cancer. We used the data from the multicenter, multinational RIETE registry to compare the rates of VTE recurrences, major bleeding, or death over 6 months in patients with active cancer and acute VTE using full doses of enoxaparin versus dalteparin or tinzaparin, and a multivariable Cox proportional hazard model was used to analyze the primary end point. From January 2009 to June 2018, 4451 patients with active cancer received full doses of the study drugs: enoxaparin, 3526 patients; and dalteparin or tinzaparin, 925 (754 + 171) patients. There was limited difference in VTE recurrences (2.0% vs 2.5%) and mortality rate (19% vs 17%) between the enoxaparin and dalteparin or tinzaparin subgroups. However, there was a slight numerical increase in major bleeding (3.1% vs 1.9%). Propensity score matching confirmed that there were no differences in the risk for VTE recurrences (adjusted hazard ratio [aHR], 0.81; 95% confidence interval [CI], 0.48-1.38), major bleeding (aHR, 1.40; 95% CI, 0.80-2.46), or death (aHR, 1.07; 95% CI, 0.88-1.30) between subgroups. In RIETECAT, in patients with cancer and VTE receiving full-dose enoxaparin or dalteparin or tinzaparin, no statistically significant differences were observed regarding effectiveness and safety outcomes over a 6-month period.

Published
2022

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