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13. Comparisons of polybrominated diphenyl ethers levels in paired South Korean cord blood, maternal blood, and breast milk samples

Author

Kim, Tae Hyung, primary, Bang, Du Yeon, additional, Lim, Hyun Jung, additional, Jin Won, A., additional, Ahn, Mee Young, additional, Patra, Nabanita, additional, Chung, Ki Kyung, additional, Kwack, Seung Jun, additional, Park, Kui Lea, additional, Han, Soon Young, additional, Choi, Wahn Soo, additional, Han, Jung Yeol, additional, Lee, Byung Mu, additional, Oh, Jeong-Eun, additional, Yoon, Jeong-Hyun, additional, Lee, Jaewon, additional, and Kim, Hyung Sik, additional

Published
2012
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14. Evaluation of liver and thyroid toxicity in Sprague-Dawley rats after exposure to polybrominated diphenyl ether BDE-209

Author

Lee, Ena, primary, Kim, Tae Hyung, additional, Choi, Jae Seok, additional, Nabanata, Patra, additional, Kim, Na Young, additional, Ahn, Mee Young, additional, Jung, Ki Kyung, additional, Kang, Il Hyun, additional, Kim, Tae Sung, additional, Kwack, Seung Jun, additional, Park, Kui Lea, additional, Kim, Seung Hee, additional, Kang, Tae Seok, additional, Lee, Jaewon, additional, Lee, Byung Mu, additional, and Kim, Hyung Sik, additional

Published
2010
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15. Effects of Di(2-ethylhexyl) Phthalate on Regulation of Steroidogenesis or Spermatogenesis in Testes of Sprague-Dawley Rats

Author

Lee, Young Jun, primary, Lee, Ena, additional, Kim, Tae Hyung, additional, Choi, Jae Seok, additional, Lee, Jaewon, additional, Jung, Ki Kyung, additional, Kwack, Seung Jun, additional, Kim, Kyu Bong, additional, Kang, Tae Seok, additional, Han, Soon Young, additional, Lee, Byung Mu, additional, and Kim, Hyung Sik, additional

Published
2009
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16. Effects of Ginsenosides on Organogenesis and Expression of Glutathione Peroxidase Genes in Cultured Rat Embryos

Author

LEE, Se-Ra, primary, KIM, Mi-Ra, additional, YON, Jung-Min, additional, BAEK, In-Jeoung, additional, LEE, Beom-Jun, additional, AHN, Byeongwoo, additional, KIM, Yun-Bae, additional, KWACK, Seung-Jun, additional, LEE, Rhee-Da, additional, KIM, Soon-Sun, additional, CHO, Dae-Hyun, additional, HUR, Gyeung-Haeng, additional, YUN, Young-Won, additional, and NAM, Sang-Yoon, additional

Published
2008
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18. Ras Transgene Expression in TG-AC Mice Treated with Benzo[a]pyrene

Author

Lee, Byung Mu, primary, Kim, Hyung Sik, additional, Kim, In Sun, additional, Ahn, Mi Young, additional, Chun, Sun Ah, additional, Yoo, Sun Dong, additional, Park, Yo An, additional, Choi, Sul Min, additional, Kim, Kyu Bong, additional, Han, Soon Young, additional, Park, Kui Lae, additional, Kwack, Seung Jun, additional, Song, Hyun Sue, additional, Lee, Kyung Rim, additional, Bae, Hye Jin, additional, and Cho, Myung Haing, additional

Published
2003
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20. Correlation between DNA or protein adducts and benzo[a]pyrene diol epoxide I–triglyceride adduct detected in vitro and in vivo.

Author

Kwack, Seung Jun and Mu Lee, Byung

Abstract

In this study, we demonstrated the in vitro and in vivo formation of carcinogen–lipid adduct and its correlation with DNA or protein adducts. The lipids from serum or hepatocyte membranes of Sprague–Dawley rats, human serum and standard major lipids were in vitro reacted with benzo[a]pyrene (B[a]P) and B[a]P metabolites. 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene(BPDE-I), an ultimate carcinogenic form of B[a]P, was covalently bound to triglyceride (TG). BPDE-I–TG adducts isolated by thin-layer chromatography (TLC) were further detected by high-performance liquid chromatography. TGs, including triolein, tripalmitin and tristearin, showed positive reactions with BPDE-I. However, cholesterol, phospholipids (phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidyl-inositol and sphingomyelin) and non-esterified fatty acids (palmitic acid, oleic acid, linoleic acid and stearic acid) did not react with BPDE-I. In addition, other B[a]P metabolites (B[a]P-phenols and -diols) did not react with TG. TG appeared to be the most reactive lipid yet studied with respect to its ability to form an adduct with BPDE-I. There was a clear-cut dose-related formation of [1,3-3H]BPDE-I–lipid adducts in vitro between TG and [1,3-3H]BPDE-I. In an animal study, BPDE-I–TG was also formed in the serum of rats orally treated with B[a]P (25 mg/rat). Also, obvious correlations between [3H]B[a]P related-biomolecule adducts (DNA or protein) or lipid damage and the BPDE-I–TG adducts were obtained in various tissues of mice i.p. treated with [3H]B[a]P. These data suggest that TG can form an adduct with BPDE-I, as do other macromolecules (DNA, RNA and protein). Therefore, a carcinogen–lipid adduct would be a useful biomarker for chemical carcinogenesis research and cancer risk assessment. [ABSTRACT FROM PUBLISHER]

Published
2000
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21. 827. Integration and Biodistribution Studies of Retroviral Vector in Mouse Gonad Tissues

Author

Rhee, Gyu Seek, Seok, Ji hyun, Kim, Soon Sun, Kwack, Seung Jun, Kim, Bo Ra, Lee, Rhee Da, Chae, Soo Yeong, Won, Young Hyuk, Yu, Seung Shin, and Cho, Dae Hyun

Subjects
*RETROVIRUSES
Abstract

An abstract of the article "Integration and Biodistribution Studies of Retroviral Vector in Mouse Gonad Tissues," by Gyu Seek Rhee, Ji hyun Seok, Soon Sun Kim, Seung Jun Kwack, Bo Ra Kim, Rhee Da Lee, Soo Yeong Chae, Young Hyuk Won, Seung Shin Yu and Dae Hyun Cho is presented.

Published
2005
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