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6. Association of Successful Percutaneous Revascularization of Chronic Total Occlusions With Quality of Life

Author

Kucukseymen, Selcuk, primary, Iannaccone, Mario, additional, Grantham, James A., additional, Sapontis, James, additional, Juricic, Stefan, additional, Ciardetti, Niccolò, additional, Mattesini, Alessio, additional, Stojkovic, Sinisa, additional, Strauss, Bradley H., additional, Wijeysundera, Harindra C., additional, Werner, Gerald S., additional, D’Ascenzo, Fabrizio, additional, and Di Mario, Carlo, additional

Published
2023
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8. CRT-100.38 Temporal Evolution of Percutaneous Recanalisation for Coronary Chronic Total Occlusions: An Italian Multicenter Experience

Author

Ciardetti, Niccolò, primary, Chechi, Tania, additional, Mattesini, Alessio, additional, Bonechi, Francesco, additional, Nardi, Giulia, additional, Di Muro, Francesca Maria, additional, Furlani, Priscilla, additional, Crociani, Maria Federica, additional, Cenni, Noemi, additional, Kucukseymen, Selcuk, additional, Meucci, Francesco, additional, Stolcova, Miroslava, additional, Ristalli, Francesca, additional, and Di Mario, Carlo, additional

Published
2023
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9. CRT-100.34 The Importance of Intravascular Ultrasound and Intravascular Lithotripsy for Complex Coronary Chronic Total Occlusion Recanalisation: An Italian Multicenter Experience

Author

Ciardetti, Niccolò, primary, Chechi, Tania, additional, Mattesini, Alessio, additional, Bonechi, Francesco, additional, Nardi, Giulia, additional, Di Muro, Francesca Maria, additional, Furlani, Priscilla, additional, Crociani, Maria Federica, additional, Cenni, Noemi, additional, Kucukseymen, Selcuk, additional, Meucci, Francesco, additional, Stolcova, Miroslava, additional, Ristalli, Francesca, additional, and Di Mario, Carlo, additional

Published
2023
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11. 279 LAYERED PLAQUES: NOT ALL ARE HEALED

Author

Ciardetti, Niccolò, primary, Mattesini, Alessio, additional, Di Muro, Francesca Maria, additional, Nardi, Giulia, additional, Kucukseymen, Selcuk, additional, Francesca, Ristalli, additional, Stolcova, Miroslava, additional, Meucci, Francesco, additional, and Di Mario, Carlo, additional

Published
2022
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15. Multi‐domain convolutional neural network (MD‐CNN) for radial reconstruction of dynamic cardiac MRI

Author

El‐Rewaidy, Hossam, Fahmy, Ahmed S, Pashakhanloo, Farhad, Cai, Xiaoying, Kucukseymen, Selcuk, Csecs, Ibolya, Neisius, Ulf, Haji‐Valizadeh, Hassan, Menze, Bjoern, Nezafat, Reza, University of Zurich, and Nezafat, Reza

Subjects
Radiology Nuclear Medicine and imaging, 2741 Radiology, Nuclear Medicine and Imaging, 610 Medicine & health, 11493 Department of Quantitative Biomedicine
Published
2021

16. Multi‐domain convolutional neural network (MD‐CNN) for radial reconstruction of dynamic cardiac MRI

Author

El‐Rewaidy, Hossam; https://orcid.org/0000-0002-5266-8702, Fahmy, Ahmed S, Pashakhanloo, Farhad, Cai, Xiaoying, Kucukseymen, Selcuk, Csecs, Ibolya, Neisius, Ulf, Haji‐Valizadeh, Hassan, Menze, Bjoern, Nezafat, Reza, El‐Rewaidy, Hossam; https://orcid.org/0000-0002-5266-8702, Fahmy, Ahmed S, Pashakhanloo, Farhad, Cai, Xiaoying, Kucukseymen, Selcuk, Csecs, Ibolya, Neisius, Ulf, Haji‐Valizadeh, Hassan, Menze, Bjoern, and Nezafat, Reza

Abstract

Purpose Cardiac MR cine imaging allows accurate and reproducible assessment of cardiac function. However, its long scan time not only limits the spatial and temporal resolutions but is challenging in patients with breath‐holding difficulty or non‐sinus rhythms. To reduce scan time, we propose a multi‐domain convolutional neural network (MD‐CNN) for fast reconstruction of highly undersampled radial cine images. Methods MD‐CNN is a complex‐valued network that processes MR data in k‐space and image domains via k‐space interpolation and image‐domain subnetworks for residual artifact suppression. MD‐CNN exploits spatio‐temporal correlations across timeframes and multi‐coil redundancies to enable high acceleration. Radial cine data were prospectively collected in 108 subjects (50 ± 17 y, 72 males) using retrospective‐gated acquisition with 80%:20% split for training/testing. Images were reconstructed by MD‐CNN and k‐t Radial Sparse‐Sense(kt‐RASPS) using an undersampled dataset (14 of 196 acquired views; relative acceleration rate = 14). MD‐CNN images were evaluated quantitatively using mean‐squared‐error (MSE) and structural similarity index (SSIM) relative to reference images, and qualitatively by three independent readers for left ventricular (LV) border sharpness and temporal fidelity using 5‐point Likert‐scale (1‐non‐diagnostic, 2‐poor, 3‐fair, 4‐good, and 5‐excellent). Results MD‐CNN showed improved MSE and SSIM compared to kt‐RASPS (0.11 ± 0.10 vs. 0.61 ± 0.51, and 0.87 ± 0.07 vs. 0.72 ± 0.07, respectively; P < .01). Qualitatively, MD‐CCN significantly outperformed kt‐RASPS in LV border sharpness (3.87 ± 0.66 vs. 2.71 ± 0.58 at end‐diastole, and 3.57 ± 0.6 vs. 2.56 ± 0.6 at end‐systole, respectively; P < .01) and temporal fidelity (3.27 ± 0.65 vs. 2.59 ± 0.59; P < .01). Conclusion MD‐CNN reduces the scan time of cine imaging by a factor of 23.3 and provides superior image quality compared to kt‐RASPS.

Published
2021

18. Discordance in Scar Detection Between Electroanatomical Mapping and Cardiac MRI in an Infarct Swine Model

Author

Kucukseymen, Selcuk, primary, Yavin, Hagai, additional, Barkagan, Michael, additional, Jang, Jihye, additional, Shapira-Daniels, Ayelet, additional, Rodriguez, Jennifer, additional, Shim, David, additional, Pashakhanloo, Farhad, additional, Pierce, Patrick, additional, Botzer, Lior, additional, Manning, Warren J., additional, Anter, Elad, additional, and Nezafat, Reza, additional

Published
2020
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22. Heart Rate Recovery as a Novel Test for Predicting Cardiac Involvement in Beta-Thalassemia Major

Author

Kucukseymen, Selcuk, Oner Yuksel, Isa, Cagirci, Goksel, Koklu, Erkan, Karakus, Volkan, Cay, Serkan, Kus, Gorkem, Kurtoglu, Erdal, and Arslan, Sakir

Subjects
Original Article
Abstract

Abnormal heart rate recovery (HRR) is predictive of cardiac mortality. Autonomic abnormalities in beta-thalassemia major (TM) patients have been reported in previous studies. However, the importance of low HRR in exercise stress test in TM patients has not yet been ascertained. Therefore, this study will be the first of its kind in the literature.Exercise stress test was performed on 56 TM patients who were being treated at the Thalassemia Center of our hospital, along with 46 non-TM iron deficiency anemia (IDA) patients as a control group. Values for HHR were recorded at 1, 2, 3, 4 and 5 min, and HRR was calculated by the difference of heart rate at peak exercise and at a specific time interval following the onset of recovery.All HRR values were found to be lower in TM patients compared to those in the IDA group. Exercise capacity [metabolic equivalents (METs)] was also found to be low in these patients (p0.001) as well. Total exercise time was significantly lower in the TM group compared to the IDA group (8.40 ± 1.7 min vs. 11.17 ± 1.51 min, p0.001). Exercise capacity (METs) was also lower in the TM group compared to the IDA group. Mean T2* value was 28.3 ± 13.7 ms in TM patients on magnetic resonance imaging (MRI). In addition, there are 18 TM patients with T2* value was20 ms.This study found that TM was independently associated with low HRR. Such a condition is an indicator of autonomic dysfunction in TM patients, since abnormal HRR is related to impaired autonomic response. In addition, impaired HRR may be a marker of early cardiac involvement in patients, whose T2* value is high on MRI. Modifying HRR with a cardiac rehabilitation program in TM patients with impaired HRR is a field open for further investigation.

Published
2017

23. Management of Left Ventricular Free Wall Rupture Associated with Acute Myocardial Infarction

Author

Koklu, Erkan, Arslan, Sakir, Yuksel, Isa Oner, Bayar, Nermin, Yilmaz, Gulsum Meral, and Kucukseymen, Selcuk

Subjects
cardiovascular system, Case Report, cardiovascular diseases
Abstract

Left ventricular free wall rupture is one of the mechanical complications of acute myocardial infarction and it may result in cardiac tamponade as well as limiting itself by forming a pseudoaneurysm. In this report, a case of left ventricular free wall rupture and pseudoaneurysm that developed during the course of posterior myocardial infarction has been presented. Left ventricular free wall rupture and pseudoaneurysm were identified by three-dimensional transthoracic echocardiography and surgically repaired at a late stage.

Published
2017

24. The Association between Serum Ferritin Level, Tissue Doppler Echocardiography, Cardiac T2* MRI, and Heart Rate Recovery in Patients with Beta Thalassemia Major

Author

Yuksel, Isa Oner, Koklu, Erkan, Kurtoglu, Erdal, Arslan, Sakir, Cagirci, Goksel, Karakus, Volkan, Kus, Gorkem, Cay, Serkan, and Kucukseymen, Selcuk

Subjects
Original Article
Abstract

It is generally well-understood that iron-mediated cardiomyopathy is the major complication that can arise from beta thalassemia major (TM). Therefore, early diagnosis, risk stratification, and the effective treatment of beta TM patients are clinically important to optimize long-term positive outcomes.This study included 57 beta TM patients with a mean age of 25 ± 7 years. We determined the serum ferritin level, echocardiography, heart rate recovery (HRR), and cardiac magnetic resonance (CMR) T2* in all patients. CMR T2* findings were categorized as normal myocardium (T2*20 ms), and myocardial involvement (T2* ≤ 20 ms). HRR values at 1-5 min (HRR1-5) were recorded; Subsequently. HRR was calculated by subtracting the heart rate at each time point from the heart rate at peak exercise.There was a significant negative correlation between the serum ferritin level and the cardiac T2* MRI findings (r = -0.34, p = 0.009). A similar result was found in the negative correlation between serum ferritin and all heart rate recovery values. There was a significant positive correlation between HRR1, HRR2, and HRR3 values, and CMR T2* (T2* heart rate recovery (HRR)1: r = 0.51, p0.001; T2* HRR2: r = 0.48, p0.001; T2* HRR3: r = 0.47, p0.001, respectively).The serum ferritin level and echocardiography can be used to predict the presence of myocardial iron load in beta TM patients. Therefore, HRR can be used to screen beta TM patients, and the clinical use of HRR can be a predictive marker for autonomic dysfunction in beta TM patients.Beta thalassemia major • Cardiac magnetic resonance T2* • Heart rate recovery • Iron overload • Serum ferritin level • Tissue Doppler imaging.

Published
2016

34. Abstract 14448: Negative Synergism of Diabetes Mellitus and Obesity on the Myocardium in Patients With Heart Failure With Preserved Ejection Fraction: A Cardiovascular Magnetic Resonance Study

Author

Kucukseymen, Selcuk, Neisius, Ulf, Tsao, Connie W, and Nezafat, Reza

Abstract

Introduction:Diabetes mellitus (DM) and obesity are major risk factors for the development of heart failure with preserved ejection fraction (HFpEF). The conjoint impact of these entities on myocardial structure and function is unknown. We sought to investigate myocardial fibrosis and longitudinal contractility in relation to obesity, DM and the combination of both in HFpEF patients.Methods:A 162-patient with HFpEF (55?12 years, 59% men) were categorized according to prevalence of DM and obesity (BMI >30 kg/m2) (53 lean-DM, 73 obese-DM, 36 non-DM obese), and compared with 45 healthy subjects (53?12 years, 61% men). HFpEF was diagnosed based on echocardiographic diastolic dysfunction, NYHA status ?2 and H2FPEF score ? 6. We acquired cardiovascular magnetic resonance slice-interleaved native T1mapping (STONE) and cine SSFP imaging for interstitial fibrosis and global longitudinal strain (GLS) measurements (CVI42, Circle Cardiovascular Imaging), respectively. Based on medical records, the effect of body fat burden on insulin resistance (IR) was characterized by the triglyceride-glucose index adiposity status (TyG-BMI = Ln[Triglycerides (mg/ml) * fasting glucose (mg/ml)/2]*BMI).Results:In comparison to lean DM HFpEF patients, Obese-DM had reduced GLS (-14.9?2.2 vs-16.5?2.2%, P<0.001) and increased myocardial fibrosis (native T1, 1130?26 vs 1162?37 ms, P<0.001) (Fig 1A). This trend continued in non-DM obese HFpEF patients and controls (P<0.001 for both). TyG-BMI was correlated with GLS (R=0.590, P<0.001) and native T1(R=0.349, P<0.001) suggesting an association of severity of fat-insulin resistance with myocardial deformation and interstitial fibrosis (Fig 1B).Conclusions:This combination in HFpEF patients is associated with GLS decline and diffuse fibrosis, suggesting their negative synergistic effect on the myocardium. The link between fat-IR and these imaging markers underlines the impact of DM and obesity severity on myocardial health.

Published
2019
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35. Heart Rate Recovery as a Novel Test for Predicting Cardiac Involvement in Beta-Thalassemia Major.

Author

Kucukseymen S, Oner Yuksel I, Cagirci G, Koklu E, Karakus V, Cay S, Kus G, Kurtoglu E, and Arslan S

Abstract

Background: Abnormal heart rate recovery (HRR) is predictive of cardiac mortality. Autonomic abnormalities in beta-thalassemia major (TM) patients have been reported in previous studies. However, the importance of low HRR in exercise stress test in TM patients has not yet been ascertained. Therefore, this study will be the first of its kind in the literature., Methods: Exercise stress test was performed on 56 TM patients who were being treated at the Thalassemia Center of our hospital, along with 46 non-TM iron deficiency anemia (IDA) patients as a control group. Values for HHR were recorded at 1, 2, 3, 4 and 5 min, and HRR was calculated by the difference of heart rate at peak exercise and at a specific time interval following the onset of recovery., Results: All HRR values were found to be lower in TM patients compared to those in the IDA group. Exercise capacity [metabolic equivalents (METs)] was also found to be low in these patients (p < 0.001) as well. Total exercise time was significantly lower in the TM group compared to the IDA group (8.40 ± 1.7 min vs. 11.17 ± 1.51 min, p < 0.001). Exercise capacity (METs) was also lower in the TM group compared to the IDA group. Mean T2* value was 28.3 ± 13.7 ms in TM patients on magnetic resonance imaging (MRI). In addition, there are 18 TM patients with T2* value was < 20 ms., Conclusions: This study found that TM was independently associated with low HRR. Such a condition is an indicator of autonomic dysfunction in TM patients, since abnormal HRR is related to impaired autonomic response. In addition, impaired HRR may be a marker of early cardiac involvement in patients, whose T2* value is high on MRI. Modifying HRR with a cardiac rehabilitation program in TM patients with impaired HRR is a field open for further investigation.

Published
2017
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36. Management of Left Ventricular Free Wall Rupture Associated with Acute Myocardial Infarction.

Author

Koklu E, Arslan S, Yuksel IO, Bayar N, Yilmaz GM, and Kucukseymen S

Abstract

Left ventricular free wall rupture is one of the mechanical complications of acute myocardial infarction and it may result in cardiac tamponade as well as limiting itself by forming a pseudoaneurysm. In this report, a case of left ventricular free wall rupture and pseudoaneurysm that developed during the course of posterior myocardial infarction has been presented. Left ventricular free wall rupture and pseudoaneurysm were identified by three-dimensional transthoracic echocardiography and surgically repaired at a late stage., (Copyright © 2017 by Taiwan Society of Emergency Medicine & Ainosco Press. All Rights Reserved.)

Published
2017
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37. The Association between Serum Ferritin Level, Tissue Doppler Echocardiography, Cardiac T2* MRI, and Heart Rate Recovery in Patients with Beta Thalassemia Major.

Author

Yuksel IO, Koklu E, Kurtoglu E, Arslan S, Cagirci G, Karakus V, Kus G, Cay S, and Kucukseymen S

Abstract

Background: It is generally well-understood that iron-mediated cardiomyopathy is the major complication that can arise from beta thalassemia major (TM). Therefore, early diagnosis, risk stratification, and the effective treatment of beta TM patients are clinically important to optimize long-term positive outcomes., Methods: This study included 57 beta TM patients with a mean age of 25 ± 7 years. We determined the serum ferritin level, echocardiography, heart rate recovery (HRR), and cardiac magnetic resonance (CMR) T2* in all patients. CMR T2* findings were categorized as normal myocardium (T2* > 20 ms), and myocardial involvement (T2* ≤ 20 ms). HRR values at 1-5 min (HRR1-5) were recorded; Subsequently. HRR was calculated by subtracting the heart rate at each time point from the heart rate at peak exercise., Results: There was a significant negative correlation between the serum ferritin level and the cardiac T2* MRI findings (r = -0.34, p = 0.009). A similar result was found in the negative correlation between serum ferritin and all heart rate recovery values. There was a significant positive correlation between HRR1, HRR2, and HRR3 values, and CMR T2* (T2* heart rate recovery (HRR)1: r = 0.51, p < 0.001; T2* HRR2: r = 0.48, p < 0.001; T2* HRR3: r = 0.47, p < 0.001, respectively)., Conclusions: The serum ferritin level and echocardiography can be used to predict the presence of myocardial iron load in beta TM patients. Therefore, HRR can be used to screen beta TM patients, and the clinical use of HRR can be a predictive marker for autonomic dysfunction in beta TM patients., Key Words: Beta thalassemia major • Cardiac magnetic resonance T2* • Heart rate recovery • Iron overload • Serum ferritin level • Tissue Doppler imaging.

Published
2016
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