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5. Ultrasonographic Contrast and Therapeutic Effects of Hydrogen Peroxide-Responsive Nanoparticles in a Rat Model with Sciatic Neuritis

Author

Kim,Da-Sol, Jo,Nam-Gyu, Lee,Dong-Won, Ko,Myoung-Hwan, Seo,Jeong-Hwan, Kim,Gi-Wook, Kim,Da-Sol, Jo,Nam-Gyu, Lee,Dong-Won, Ko,Myoung-Hwan, Seo,Jeong-Hwan, and Kim,Gi-Wook

Abstract

Da-Sol Kim,1,2,* Nam-Gyu Jo,3,* Dong-Won Lee,4,5 Myoung-Hwan Ko,1,2 Jeong-Hwan Seo,1,2 Gi-Wook Kim1,2,4 1Department of Physical Medicine & Rehabilitation, Jeonbuk National University Medical School, Jeonju, Republic of Korea; 2Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea; 3Department of Physical Medicine and Rehabilitation, Hansol Convalescence Rehabilitation Hospital, Jeonju, Republic of Korea; 4Department of Bionanotechnology and Bioconvergence Engineering, Jeonbuk National University, Jeonju, Republic of Korea; 5Department of Polymer Nano Science and Technology, Jeonbuk National University, Jeonju, Republic of Korea*These authors contributed equally to this workCorrespondence: Gi-Wook Kim, Department of Physical Medicine & Rehabilitation, Jeonbuk National University Medical School, Geonjiro 20, Deokjin-gu, Jeonju, Jeonbuk, 54907, Republic of Korea, Tel +82-63-259-3144, Fax +82-10-254-4145, Email k26@jbnu.ac.krPurpose: Peripheral nerve damage lacks an appropriate diagnosis consistent with the patient’s symptoms, despite expensive magnetic resonance imaging or electrodiagnostic assessments, which cause discomfort. Ultrasonography is valuable for diagnosing and treating nerve lesions; however, it is unsuitable for detecting small lesions. Poly(vanillin-oxalate) (PVO) nanoparticles are prepared from vanillin, a phytochemical with antioxidant and anti-inflammatory properties. Previously, PVO nanoparticles were cleaved by H2O2 to release vanillin, exert therapeutic efficacy, and generate CO2 to increase ultrasound contrast. However, the role of PVO nanoparticles in peripheral nerve lesion models is still unknown. Herein, we aimed to determine whether PVO nanoparticles can function as contrast and therapeutic agents for nerve lesions.Methods: To induce sciatic neuritis, rats were administered a perineural injection

Published
2024

7. Effect of Pre- and Post-Dialysis Exercise on Functional Capacity Using Portable Ergometer in Chronic Kidney Disease Patients.

Author

Chae, Tae-Seok, Kim, Da-Sol, Ko, Myoung-Hwan, and Won, Yu Hui

Subjects
CHRONIC kidney failure, HEMODIALYSIS, CHRONICALLY ill, AEROBIC capacity, HEMODIAFILTRATION, FUNCTIONAL status, DYNAMOMETER
Abstract

Objective: To assess whether performing exercises during hemodialysis reduces the risk of developing intradialytic hypotension and enhances exercise capacity in patients with chronic kidney disease. Methods: This study included patients aged ≥18 years undergoing hemodialysis. Participants performed exercises using a portable lower extremity ergometer during hemodialysis sessions for 3 weeks. Data regarding walking distance, knee strength, quality of life, fat-free mass, arterial pressure, blood pressure, heart rate, frequency of intradialytic hypotension, fatigue, and duration of hemodialysis were collected and analyzed. Results: Significant improvements in walking distance and knee strength were observed following the implementation of exercise training during hemodialysis. Although there was no significant reduction in the frequency of intradialytic hypotension, a decreasing trend was noted. Other parameters such as quality of life and fatigue did not show significant changes. Conclusion: Using a portable ergometer during hemodialysis improved exercise capacity and knee strength in patients with chronic kidney disease. There was a trend toward reduced intradialytic hypotension, suggesting potential cardiovascular benefits. Further research with larger sample sizes is needed to confirm these findings. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Efficacy of an Integrated Training Device in Improving Muscle Strength, Balance, and Cognitive Ability in Older Adults

Author

Roh, Choong-Hee, Kim, Da-Sol, Kim, Gi-Wook, Won, Yu-Hui, Park, Sung-Hee, Seo, Jeong-Hwan, and Ko, Myoung-Hwan

Subjects
cognition, medicine.medical_specialty, business.industry, Rehabilitation, Montreal Cognitive Assessment, Cognition, Timed Up and Go test, elderly, Cognitive training, Test (assessment), integrated training device, Berg Balance Scale, muscle strength, Postural Balance, Physical therapy, medicine, Medicine, Original Article, business, postural balance, Balance (ability)
Abstract

Objective To determine the effects of an integrated training device for strength and balance on extremity muscle strength, postural balance, and cognition in older adults using a combination with various rehabilitation training games, in which balance, strength, and cognitive training were configured in a single device.Methods This prospective study included 20 healthy participants aged 65–85 years. Participants trained for 30 minutes daily, 3 days weekly, for 6 weeks with an integrated training device for strength and balance (SBT-120; Man&Tel Inc., Gumi, Korea). Main outcomes were measured using the Korean Mini-Mental State Examination (K-MMSE), Korean version of the Montreal Cognitive Assessment (K-MoCA), Timed Up and Go Test (TUG), Functional Reach Test (FRT), Berg Balance Scale (BBS), and Manual Muscle Test. Measurements were taken at three time points: T0 (pretreatment), T1 (immediately after treatment), and T2 (4 weeks after treatment).Results All 20 patients completed the training, and TUG, FRT, and BBS scores significantly improved at T1 and T2 compared to T0. Mean TUG scores decreased by 0.99±2.00 at T1 and 1.05±1.55 at T2 compared to T0. Mean FRT scores increased by 6.13±4.26 at T1 and 6.75±4.79 at T2 compared to T0. BBS scores increased by 0.60±0.94 at T1 and 0.45±1.15 at T2 compared to T0. Moreover, muscle strength and cognition (K-MMSE and K-MoCA scores) increased after training.Conclusion Our findings suggest that an integrated training device for strength and balance can be a safe and useful tool for older adults.

Published
2021

22. sj-pdf-1-imr-10.1177_03000605221104768 - Supplemental material for Association of bladder trabeculation and neurogenic bladder with spinal cord injury

Author

Won, Yu Hui, Kim, Da-Sol, Kim, Gi-Wook, Park, Sung-Hee, Ko, Myoung-Hwan, and Seo, Jeong-Hwan

Subjects
111199 Nutrition and Dietetics not elsewhere classified, Cardiology, 170199 Psychology not elsewhere classified, 111799 Public Health and Health Services not elsewhere classified, 110604 Sports Medicine, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology, 111099 Nursing not elsewhere classified, 111708 Health and Community Services, 160807 Sociological Methodology and Research Methods, 111702 Aged Health Care, 111403 Paediatrics, 110904 Neurology and Neuromuscular Diseases, 110203 Respiratory Diseases, 110315 Otorhinolaryngology, FOS: Clinical medicine, 110319 Psychiatry (incl. Psychotherapy), FOS: Sociology, FOS: Psychology, 110599 Dentistry not elsewhere classified, 110323 Surgery, 110305 Emergency Medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-imr-10.1177_03000605221104768 for Association of bladder trabeculation and neurogenic bladder with spinal cord injury by Yu Hui Won, Da-Sol Kim, Gi-Wook Kim, Sung-Hee Park, Myoung-Hwan Ko and Jeong-Hwan Seo in Journal of International Medical Research

Published
2022
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33. Effects of ICT-Based Multicomponent Program on Body Composition and Cognitive Function in Older Adults: A Randomized Controlled Clinical Study

Author

Kim,Du-Ri, Song,Seunghwan, Kim,Gwon-Min, Chang,Jae Hyeok, Tak,Young Jin, Huh,Up, Cho,Jeong Su, Liao,Yung, Han,Kap-Soo, Ko,Myoung-Hwan, Park,Jong-Hwan, Kim,Du-Ri, Song,Seunghwan, Kim,Gwon-Min, Chang,Jae Hyeok, Tak,Young Jin, Huh,Up, Cho,Jeong Su, Liao,Yung, Han,Kap-Soo, Ko,Myoung-Hwan, and Park,Jong-Hwan

Abstract

Du-Ri Kim1,2 *, Seunghwan Song1,3 *, Gwon-Min Kim,1 Jae Hyeok Chang,1,4 Young Jin Tak,5 Up Huh,1,3 Jeong Su Cho,3 Yung Liao,6 Kap-Soo Han,7 Myoung-Hwan Ko,7,8 Jong-Hwan Park1 1Health Convergence Medicine Laboratory, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea; 2Department of Occupational Therapy, Graduate School of Inje University, Gimhae, Korea; 3Department of Thoracic and Cardiovascular Surgery, School of Medicine, Pusan National University, Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Busan, Korea; 4Department of Rehabilitation Medicine, School of Medicine, Pusan National University, Department of Rehabilitation Medicine, Pusan National University Hospital, Busan, Korea; 5Department of Family Medicine, Pusan National University Hospital, Busan, Korea; 6Department of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan; 7Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea; 8Department of Physical Medicine and Rehabilitation, Jeonbuk National University Medical School, Jeonju, Korea*These authors contributed equally to this workCorrespondence: Myoung-Hwan KoDepartment of Physical Medicine and Rehabilitation, Jeonbuk National University Medical School, 20 Geonji-ro, Deokjin-gu, Jeonju, 54907, KoreaTel +82-63-250-1785Email mhko@jbnu.ac.krJong-Hwan ParkHealth Convergence Medicine Laboratory, Biomedical Research Institute, Pusan National University Hospital, 179, Gudeok-Ro, Seo-Gu, Busan, 49241, KoreaTel +82-51-240-7071Email parkj@pusan.ac.krPurpose: Information and communication technology (ICT)-based training devices for older adults’ care related to dementia are being developed to enhance older adults’ cognitive functions. Older adults who require bicycle training devices can improve muscle strength and balance of lower limbs by con

Published
2021

37. Effects of ICT-based Multicomponent Program on Body Composition and Cognitive Function in Older Adults: A Randomized Controlled Clinical Study (Preprint)

Author

Kim, Du-Ri, primary, Song, Seunghwan, additional, Kim, Gwon-Min, additional, Chang, Jae Hyeok, additional, Tak, Young Jin, additional, Huh, Up, additional, Cho, Jeong Su, additional, Liao, Yung, additional, Han, Kap-Soo, additional, Ko, Myoung-Hwan, additional, and Park, Jong-Hwan, additional

Published
2020
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48. Supplementation with extract of Gynostemma pentaphyllum leaves reduces anxiety in healthy subjects with chronic psychological stress: A randomized, double-blind, placebo-controlled clinical trial

Author

Choi, Eun-Kyung, primary, Won, Yu Hui, additional, Kim, Soon-Young, additional, Noh, Soon-Ok, additional, Park, Soo-Hyun, additional, Jung, Su-Jin, additional, Lee, Chong Kil, additional, Hwang, Bang Yeon, additional, Lee, Myung Koo, additional, Ha, Ki-Chan, additional, Baek, Hyang-Im, additional, Kim, Hye-Mi, additional, Ko, Myoung-Hwan, additional, and Chae, Soo-Wan, additional

Published
2019
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