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2. Efficacy and Safety of Topical Tacrolimus Microemulsion Applied Twice Daily in Patients with Mild to Moderate Scalp Psoriasis.

Author

Pinter, Andreas, Tsianakas, Athanasios, Eichner, Adina, for the ScaTAC study group, Paul, Carle, Passeron, Thierry, Reygagne, Pascal, Ruer, Mireille, Beissert, Stefan, Dirschka, Thomas, Gerdes, Sascha, Leitz, Nicolas, Pauser, Sylvia, Weirich, Oliver, Wildfeuer, Thomas, Kleinheinz, Andreas, Niesmann, Johannes, Crainic, Adrian, and Weber, Ridwan

Published
2024
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3. Urticaria exacerbations and adverse reactions in patients with chronic urticaria receiving COVID-19 vaccination:Results of the UCARE COVAC-CU study

Author

Kocatürk, Emek, Salameh, Pascale, Sarac, Esra, Vera Ayala, Carolina E., Thomsen, Simon Francis, Zuberbier, Torsten, Ensina, Luis Felipe, Popov, Todor A., van Doorn, Martijn B.A., Giménez-Arnau, Ana Maria, Asero, Riccardo, Criado, Paulo Ricardo, Aarestrup, Fernando M., AbdulHameed Ansari, Zainab, Al Abri, Salma, Al Ahmad, Mona, Al Hinai, Bushra, Allenova, Anastasiia, Al-Nesf, Maryam, Altrichter, Sabine, Arnaout, Rand, Bartosińska, Joanna, Bauer, Andrea, Bernstein, Jonathan A., Bizjak, Mojca, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Calvalcanti Dela Bianca Melo, Ana Caroline, Campinhos, Fernanda L., Carne, Emily, Purayil, Saleema Cherichi, Cherrez-Ojeda, Ivan, Chong-Neto, Herberto Jose, Christoff, George, Conlon, Niall, Jardim Criado, Roberta Fachini, Cvenkel, Klara, Damadoglu, Ebru, Danilycheva, Inna, Day, Cascia, de Montjoye, Laurence, Demir, Semra, Ferucci, Silvia Mariel, Fomina, Daria, Fukunaga, Atsushi, Garcia, Elizabeth, Gelincik, Asli, Göbel, Joe Hannah, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Gugala, Agata, Guillet, Carole, Kalyoncu, Ali Fuat, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Khoshkhui, Maryam, Kleinheinz, Andreas, Kolacinska-Flont, Marta, Kolkhir, Pavel, Košnik, Mitja, Krasowska, Dorota, Kumaran, Muthu Sendhil, Kuprys-Lipinska, Izabela, Kurowski, Marcin, Kuznetsova, Elizaveta V., Larenas-Linnemann, Désirée, Lebedkina, Marina S., Lee, Youngsoo, Makris, Michael P., Gómez, René Maximiliano, Nasr, Iman, Neisinger, Sophia, Oda, Yoshiko, Kara, Rabia Öztaş, Palitot, Esther Bastos, Papapostolou, Niki, Salvador Parisi, Claudio Alberto, Pesque, David, Peter, Jonathan, Petkova, Elena, Ridge, Katie, Rudenko, Michael, Rutkowski, Krzysztof, Saini, Sarbjit S., Salman, Andac, Sanchez, Jorge, Şekerel, Bülent, Serdotetskova, Sofia A., Serpa, Faradiba S., Dikicier, Bahar Sevimli, Sidiropoulos, Nikitas, Sikora, Agnieszka, Sørensen, Jennifer Astrup, Soria, Angele, Kucuk, Ozlem Su, Thalappil, Sherin Rahim, Tomaszewska, Katarzyna, Tuncay, Gulseren, Unal, Derya, Valle, Solange, van Lindonk, Esmee, Vestergaard, Christian, Vitchuk, Aleksandr, Xepapadaki, Paraskevi, Ye, Young Min, Zalewska-Janowska, Anna, Zamlynski, Mateusz, Maurer, Marcus, Kocatürk, Emek, Salameh, Pascale, Sarac, Esra, Vera Ayala, Carolina E., Thomsen, Simon Francis, Zuberbier, Torsten, Ensina, Luis Felipe, Popov, Todor A., van Doorn, Martijn B.A., Giménez-Arnau, Ana Maria, Asero, Riccardo, Criado, Paulo Ricardo, Aarestrup, Fernando M., AbdulHameed Ansari, Zainab, Al Abri, Salma, Al Ahmad, Mona, Al Hinai, Bushra, Allenova, Anastasiia, Al-Nesf, Maryam, Altrichter, Sabine, Arnaout, Rand, Bartosińska, Joanna, Bauer, Andrea, Bernstein, Jonathan A., Bizjak, Mojca, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Calvalcanti Dela Bianca Melo, Ana Caroline, Campinhos, Fernanda L., Carne, Emily, Purayil, Saleema Cherichi, Cherrez-Ojeda, Ivan, Chong-Neto, Herberto Jose, Christoff, George, Conlon, Niall, Jardim Criado, Roberta Fachini, Cvenkel, Klara, Damadoglu, Ebru, Danilycheva, Inna, Day, Cascia, de Montjoye, Laurence, Demir, Semra, Ferucci, Silvia Mariel, Fomina, Daria, Fukunaga, Atsushi, Garcia, Elizabeth, Gelincik, Asli, Göbel, Joe Hannah, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Gugala, Agata, Guillet, Carole, Kalyoncu, Ali Fuat, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Khoshkhui, Maryam, Kleinheinz, Andreas, Kolacinska-Flont, Marta, Kolkhir, Pavel, Košnik, Mitja, Krasowska, Dorota, Kumaran, Muthu Sendhil, Kuprys-Lipinska, Izabela, Kurowski, Marcin, Kuznetsova, Elizaveta V., Larenas-Linnemann, Désirée, Lebedkina, Marina S., Lee, Youngsoo, Makris, Michael P., Gómez, René Maximiliano, Nasr, Iman, Neisinger, Sophia, Oda, Yoshiko, Kara, Rabia Öztaş, Palitot, Esther Bastos, Papapostolou, Niki, Salvador Parisi, Claudio Alberto, Pesque, David, Peter, Jonathan, Petkova, Elena, Ridge, Katie, Rudenko, Michael, Rutkowski, Krzysztof, Saini, Sarbjit S., Salman, Andac, Sanchez, Jorge, Şekerel, Bülent, Serdotetskova, Sofia A., Serpa, Faradiba S., Dikicier, Bahar Sevimli, Sidiropoulos, Nikitas, Sikora, Agnieszka, Sørensen, Jennifer Astrup, Soria, Angele, Kucuk, Ozlem Su, Thalappil, Sherin Rahim, Tomaszewska, Katarzyna, Tuncay, Gulseren, Unal, Derya, Valle, Solange, van Lindonk, Esmee, Vestergaard, Christian, Vitchuk, Aleksandr, Xepapadaki, Paraskevi, Ye, Young Min, Zalewska-Janowska, Anna, Zamlynski, Mateusz, and Maurer, Marcus

Abstract

Background: Concern about disease exacerbations and fear of reactions after coronavirus disease 2019 (COVID-19) vaccinations are common in chronic urticaria (CU) patients and may lead to vaccine hesitancy. Objective: We assessed the frequency and risk factors of CU exacerbation and adverse reactions in CU patients after COVID-19 vaccination. Methods: COVAC-CU is an international multicenter study of Urticaria Centers of Reference and Excellence (UCAREs) that retrospectively evaluated the effects of COVID-19 vaccination in CU patients aged ≥18 years and vaccinated with ≥1 dose of any COVID-19 vaccine. We evaluated CU exacerbations and severe allergic reactions as well as other adverse events associated with COVID-19 vaccinations and their association with various CU parameters. Results: Across 2769 COVID-19–vaccinated CU patients, most (90%) received at least 2 COVID-19 vaccine doses, and most patients received CU treatment and had well-controlled disease. The rate of COVID-19 vaccination–induced CU exacerbation was 9%. Of 223 patients with CU exacerbation after the first dose, 53.4% experienced recurrence of CU exacerbation after the second dose. CU exacerbation most often started <48 hours after vaccination (59.2%), lasted for a few weeks or less (70%), and was treated mainly with antihistamines (70.3%). Factors that increased the risk for COVID-19 vaccination–induced CU exacerbation included female sex, disease duration shorter than 24 months, having chronic spontaneous versus inducible urticaria, receipt of adenovirus viral vector vaccine, having nonsteroidal anti-inflammatory drug/aspirin intolerance, and having concerns about getting vaccinated; receiving omalizumab treatment and Latino/Hispanic ethnicity lowered the risk. First-dose vaccine–related adverse effects, most commonly local reactions, fever, fatigue, and muscle pain, were reported by 43.5% of CU patients. Seven patients reported severe allergic reactions. Conclusions: COVID-19 vaccination lead

Published
2023

4. Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany

Author

Weisshaar, Elke, primary, Bentz, Philipp, additional, Apfelbacher, Christian, additional, Haufe, Eva, additional, Heinrich, Luise, additional, Heratizadeh, Annice, additional, Abraham, Susanne, additional, Harder, Inken, additional, Kleinheinz, Andreas, additional, Wollenberg, Andreas, additional, Schäkel, Knut, additional, Wiemers, Franca, additional, Ertner, Julia, additional, Augustin, Matthias, additional, Wildberger, Julia, additional, Von Kiedrowski, Ralph, additional, Worm, Margitta, additional, Zink, Alexander, additional, Effendy, Isaak, additional, Asmussen, Andrea, additional, Pawlak, Mario, additional, Sticherling, Michael, additional, Hilgers, Melanie, additional, Handrick, Christiane, additional, Quist, Sven, additional, Schwarz, Beate, additional, Bell, Magnus, additional, Staubach-Renz, Petra, additional, Hong-Weldemann, Sung-Hei, additional, Homey, Bernhard, additional, Brücher, Jens-Joachim, additional, Weidinger, Stephan, additional, Werfel, Thomas, additional, and Schmitt, Jochen, additional

Published
2023
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5. Perception of the coronavirus pandemic by patients with atopic dermatitis – Results from the TREATgermany registry

Author

Helmert, Claudia, Siegels, Doreen, Haufe, Eva, Abraham, Susanne, Heratizadeh, Annice, Kleinheinz, Andreas, Harder, Inken, Schäkel, Knut, Effendy, Isaak, Wollenberg, Andreas, Sticherling, Michael, Stahl, Maren, Worm, Margitta, Schwichtenberg, Uwe, Schwarz, Beate, Rossbacher, Jens, Buck, Philipp Marcel, Schenck, Florian, Werfel, Thomas, Weidinger, Stephan, and Schmitt, Jochen

Subjects
Coronavirus, Male, Quality of Life, Humans, Female, Perception, Registries, Dermatology, Pandemics, Severity of Illness Index, Dermatitis, Atopic
Abstract

TREATgermany, a registry for patients with moderate to severe atopic dermatitis (AD), established an additional questionnaire in spring 2020 to investigate the effects of the coronavirus pandemic on the daily life of patients with AD.A questionnaire was used to analyze general information regarding a patient's experience of the coronavirus pandemic and, using the Inventory of Life-Changing Events, the resulting personal burden. To analyze possible associations between disease severity (EASI score, oSCORAD, IGA, PGA, POEM), quality of life (DLQI) and personal burden, t-tests, analyses of variance and correlations were evaluated, controlled for sex and age.58 % (n = 233) of the included 400 registry patients reported high burden scores caused by the coronavirus pandemic, regardless of an actual infection. Men showed significantly higher burden scores than women, and younger than older respondents (both P = 0.03). There were no differences in burden scores related to the physician's assessment of disease severity. However, patients with higher quality of life impairments and higher disease severity perceived the burden of the coronavirus pandemic as less severe (DLQI P = 0.019, PGA P = 0.044).Our data show that registry patients considered the coronavirus pandemic as a life-changing event and perceived the burden differently. This should be taken into account in the treatment of patients with moderate to severe AD as well as in further studies.

Published
2021

6. Real-world data on the effectiveness, safety and drug survival of dupilumab: an analysis from the TREATgermany registry

Author

Stölzl, Dora, Sander, Nicole, Heratizadeh, Annice, Haufe, Eva, Harder, Inken, Abraham, Susanne, Heinrich, Luise, Kleinheinz, Andreas, Wollenberg, Andreas, Weisshaar, Elke, Schäkel, Knut, Ertner, Konstantin, Wiemers, Franca, Wildberger, Julia, Worm, Margitta, von Kiedrowski, Ralph, Effendy, Isaak, Asmussen, Andrea, Augustin, Matthias, Pawlak, Mario, Sticherling, Michael, Zink, Alexander, Hilgers, Melanie, Handrick, Christiane, Quist, Sven R., Schwarz, Beate, Staubach-Renz, Petra, Bell, Magnus, Hong-Weldemann, Sun-Hei, Homey, Bernhard, Brücher, Jens-Joachim, Schmitt, Jochen, Werfel, Thomas, and Weidinger, Stephan

Subjects
Treatment Outcome, Humans, Dermatology, Registries, Antibodies, Monoclonal, Humanized, Severity of Illness Index
Abstract

This interim analysis from the atopic dermatitis registry TREATgermany shows robust long-term efficacy, favourable safety and high persistence of dupilumab under real life conditions.

Published
2022

7. Wahrnehmung der Corona-Pandemie durch Neurodermitispatienten - Ergebnisse aus dem Neurodermitisregister TREATgermany

Author

Helmert, Claudia, Siegels, Doreen, Haufe, Eva, Abraham, Susanne, Heratizadeh, Annice, Kleinheinz, Andreas, Harder, Inken, Schäkel, Knut, Effendy, Isaak, Wollenberg, Andreas, Sticherling, Michael, Stahl, Maren, Worm, Margitta, Schwichtenberg, Uwe, Schwarz, Beate, Rossbacher, Jens, Buck, Philipp Marcel, Schenck, Florian, Werfel, Thomas, Weidinger, Stephan, and Schmitt, Jochen

Subjects
Dermatology
Abstract

Hintergrund: TREATgermany, ein Register für Patienten mit moderater bis schwerer atopischer Dermatitis (AD), etablierte im Frühjahr 2020 einen zusätzlichen Fragebogen, um Auswirkungen der Corona-Pandemie auf die Lebenssituation von Patienten mit AD zu untersuchen. Methodik: Anhand eines Fragebogens wurden allgemeine Informationen zum Erleben der Corona-Pandemie und, unter Anwendung des Inventars lebensverändernder Ereignisse, die resultierenden Belastungen der Patienten untersucht. Zur Analyse möglicher Assoziationen zwischen Erkrankungsschwere (EASI-Score, oSCORAD, IGA, PGA, POEM), Lebensqualität (DLQI) und persönlichen Belastungen wurden t-Tests, Varianzanalysen und Korrelationen kontrolliert nach Geschlecht und Alter genutzt. Ergebnisse: 58 % (N = 233) der einbezogenen 400 Registerpatienten berichteten eine hohe Belastung durch die Corona-Pandemie, unabhängig von einer tatsächlichen Infektion. Männer zeigten signifikant höhere Belastungswerte als Frauen sowie jüngere höhere als ältere Befragte (jeweils P = 0,03). Es gab keine Unterschiede der Belastungswerte bezogen auf die ärztliche Beurteilung der Erkrankungsschwere. Jedoch reflektierten Patienten mit höherer Einschränkung der Lebensqualität und ausgeprägterer Krankheitslast die Belastung durch die Corona-Pandemie als weniger hoch (DLQI P = 0,019, PGA P = 0,044). Schlussfolgerungen: Es konnte gezeigt werden, dass die Registerpatienten die Corona-Pandemie als lebensveränderndes Ereignis reflektieren und die Belastung unterschiedlich wahrnehmen. Dies sollte sowohl bei der Behandlung von Patienten mit moderater bis schwerer AD berücksichtigt als auch in weiterführenden Untersuchungen vertieft werden., BACKGROUND: TREATgermany, a registry for patients with moderate to severe atopic dermatitis (AD), established an additional questionnaire in spring 2020 to investigate the effects of the coronavirus pandemic on the daily life of patients with AD.; MATERIAL AND METHODS: A questionnaire was used to analyze general information regarding a patient's experience of the coronavirus pandemic and, using the Inventory of Life-Changing Events, the resulting personal burden. To analyze possible associations between disease severity (EASI score, oSCORAD, IGA, PGA, POEM), quality of life (DLQI) and personal burden, t-tests, analyses of variance and correlations were evaluated, controlled for sex and age.; RESULTS: 58% (n=233) of the included 400 registry patients reported high burden scores caused by the coronavirus pandemic, regardless of an actual infection. Men showed significantly higher burden scores than women, and younger than older respondents (both P=0.03). There were no differences in burden scores related to the physician's assessment of disease severity. However, patients with higher quality of life impairments and higher disease severity perceived the burden of the coronavirus pandemic as less severe (DLQI P=0.019, PGA P=0.044).; CONCLUSIONS: Our data show that registry patients considered the coronavirus pandemic as a life-changing event and perceived the burden differently. This should be taken into account in the treatment of patients with moderate to severe AD as well as in further studies. © 2021 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Published
2022

8. BJD_2022_1124_SUPPLEMENT.docx

Author

Stölzl, Dora, Sander, Nicole, Heratizadeh, Annice, Haufe, Eva, Harder, Inken, Abraham, Susanne, Heinrich, Luise, Kleinheinz, Andreas, Wollenberg, Andreas, Weisshaar, Elke, Schäkel, Kurt, Ertner, Konstantin, Wiemers, Franca, Wildberger, Julia, Worm, Margitta, Kiedrowski, Ralph von, Effendy, Isaak, Asmussen, Andrea, Augustin, Matthias, Pawlak, Mario, Sticherling, Michael, Zink, Andreas, Hilgers, Melanie, Handrick, Christiane, Quist, Sven, Schwarz, Beate, Staubach-Renz, Petra, Bell, Martin, Hong-Weldemann, Sung-Hei, Homey, Bernhard, Brücher, Jens-Joachim, Schmitt, Jochen, Werfel, Thomas, and Weidinger, Stephan

Abstract

Real-World data on effectiveness, safety and drug survival of dupilumab: An analysis from the TREATgermany registry. Table 1: Effectiveness outcomes of dupilumab and cyclosporine to month 3, 6 and 12

Published
2022
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9. Definition, aims, and implementation of GA 2 LEN/HAEi Angioedema Centers of Reference and Excellence

Author

Maurer, Marcus, Aberer, Werner, Agondi, Rosana, Al���Ahmad, Mona, Al���Nesf, Maryam Ali, Ansotegui, Ignacio, Arnaout, Rand, Arruda, Luisa Karla, Asero, Riccardo, Ayg��ren���P��rs��n, Emel, Banerji, Aleena, Bauer, Andrea, Ben���Shoshan, Moshe, Berardi, Alejandro, Bernstein, Jonathan A., Betschel, Stephen, Bindslev���Jensen, Carsten, Bizjak, Mojca, Boccon���Gibod, Isabelle, Bork, Konrad, Bouillet, Laurence, Boysen, Henrik Balle, Brodszki, Nicholas, Broesby���Olsen, Sigurd, Busse, Paula, Buttgereit, Thomas, Bygum, Anette, Caballero, Teresa, Campos, R��gis A., Cancian, Mauro, Cherrez���Ojeda, Ivan, Cohn, Danny M., Costa, C��lia, Craig, Timothy, Criado, Paulo Ricardo, Criado, Roberta F., Csuka, Dorottya, Dissemond, Joachim, Du���Thanh, Aur��lie, Ensina, Luis Felipe, Erta��, Rag��p, Fabiani, Jos�� E., Fantini, Claudio, Farkas, Henriette, Ferrucci, Silvia Mariel, Figueras���Nart, Ignasi, Fili, Natalia L., Fomina, Daria, Fukunaga, Atsushi, Gelincik, Asli, Gim��nez���Arnau, Ana, Godse, Kiran, Gompels, Mark, Gon��alo, Margarida, Gotua, Maia, Gower, Richard, Grumach, Anete S., Guidos���Fogelbach, Guillermo, Hide, Michihiro, Ilina, Natalia, Inomata, Naoko, Jakob, Thilo, Josviack, Dario O., Kang, Hye���Ryun, Kaplan, Allen, Kasperska���Zaj��c, Alicja, Katelaris, Constance, Kessel, Aharon, Kleinheinz, Andreas, Kocat��rk, Emek, Ko��nik, Mitja, Krasowska, Dorota, Kulthanan, Kanokvalai, Kumaran, M. Sendhil, Larco Sousa, Jos�� Ignacio, Longhurst, Hilary J., Lumry, William, MacGinnitie, Andrew, Magerl, Markus, Makris, Michael P., Malbr��n, Alejandro, Marsland, Alexander, Martinez���Saguer, Inmaculada, Medina, Iris V., Meshkova, Raisa, Metz, Martin, Nasr, Iman, Nicolay, Jan, Nishigori, Chikako, Ohsawa, Isao, ��zyurt, Kemal, Papadopoulos, Nikolaos G., Parisi, Claudio A. S., Peter, Jonathan Grant, Pf��tzner, Wolfgang, Popov, Todor, Prior, Nieves, Ramon, German D., Reich, Adam, Reshef, Avner, Riedl, Marc A., Ritchie, Bruce, R��ckmann���Helmbach, Heike, Rudenko, Michael, Salman, Anda��, Sanchez���Borges, Mario, Schmid���Grendelmeier, Peter, Serpa, Faradiba S., Serra���Baldrich, Esther, Sheikh, Farrukh R., Smith, William, Soria, Ang��le, Staubach, Petra, Steiner, Urs C., Stobiecki, Marcin, Sussman, Gordon, Tagka, Anna, Thomsen, Simon Francis, Treudler, Regina, Valle, Solange, Doorn, Martijn, Varga, Lilian, V��zquez, Daniel O., Wagner, Nicola, Wang, Liangchun, Weber���Chrysochoou, Christina, Ye, Young���Min, Zalewska���Janowska, Anna, Zanichelli, Andrea, Zhao, Zuotao, Zhi, Yuxiang, Zuberbier, Torsten, Zwiener, Ricardo D., and Castaldo, Anthony

Subjects
urticaria, center, angioedema, excellence, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, management
Published
2020

10. Definition, aims, and implementation of GA²LEN/HAEi Angioedema Centers of Reference and Excellence

Author

Maurer, Marcus, Aberer, Werner, Agondi, Rosana, Al-Ahmad, Mona, Al-Nesf, Maryam Ali, Ansotegui, Ignacio, Arnaout, Rand, Arruda, Luisa Karla, Asero, Riccardo, Aygören-Pürsü, Emel, Banerji, Aleena, Bauer, Andrea, Ben-Shoshan, Moshe, Berardi, Alejandro, Bernstein, Jonathan A., Betschel, Stephen, Bindslev-Jensen, Carsten, Bizjak, Mojca, Boccon-Gibod, Isabelle, Bork, Konrad, Bouillet, Laurence, Boysen, Henrik Balle, Brodszki, Nicholas, Broesby-Olsen, Sigurd, Busse, Paula, Buttgereit, Thomas, Bygum, Anette, Caballero, Teresa, Campos, Régis A., Cancian, Mauro, Cherrez-Ojeda, Ivan, Cohn, Danny M., Costa, Célia, Craig, Timothy, Criado, Paulo Ricardo, Criado, Roberta F., Csuka, Dorottya, Dissemond, Joachim, Du-Thanh, Aurélie, Ensina, Luis Felipe, Ertaş, Ragıp, Fabiani, José E., Fantini, Claudio, Farkas, Henriette, Ferrucci, Silvia Mariel, Figueras-Nart, Ignasi, Fili, Natalia L., Fomina, Daria, Fukunaga, Atsushi, Gelincik, Asli, Giménez-Arnau, Ana, Godse, Kiran, Gompels, Mark, Gonçalo, Margarida, Gotua, Maia, Gower, Richard, Grumach, Anete S., Guidos-Fogelbach, Guillermo, Hide, Michihiro, Ilina, Natalia, Inomata, Naoko, Jakob, Thilo, Josviack, Dario O., Kang, Hye-Ryun, Kaplan, Allen, Kasperska-Zając, Alicja, Katelaris, Constance, Kessel, Aharon, Kleinheinz, Andreas, Kocatürk, Emek, Košnik, Mitja, Krasowska, Dorota, Kulthanan, Kanokvalai, Kumaran, M. Sendhil, Larco Sousa, José Ignacio, Longhurst, Hilary J., Lumry, William, MacGinnitie, Andrew, Magerl, Markus, Makris, Michael P., Malbrán, Alejandro, Marsland, Alexander, Martinez-Saguer, Inmaculada, Medina, Iris V., Meshkova, Raisa, Metz, Martin, Nasr, Iman, Nicolay, Jan, Nishigori, Chikako, Ohsawa, Isao, Özyurt, Kemal, Papadopoulos, Nikolaos G., Parisi, Claudio A. S., Peter, Jonathan Grant, Pfützner, Wolfgang, Popov, Todor, Prior, Nieves, Ramon, German D., Reich, Adam, Reshef, Avner, Riedl, Marc A., Ritchie, Bruce, Röckmann-Helmbach, Heike, Rudenko, Michael, Salman, Andaç, Sanchez-Borges, Mario, Schmid-Grendelmeier, Peter, Serpa, Faradiba S., Serra-Baldrich, Esther, Sheikh, Farrukh R., Smith, William, Soria, Angèle, Staubach, Petra, Steiner, Urs C., Stobiecki, Marcin, Sussman, Gordon, Tagka, Anna, Thomsen, Simon Francis, Treudler, Regina, Valle, Solange, van Doorn, Martijn, Varga, Lilian, Vázquez, Daniel O., Wagner, Nicola, Wang, Liangchun, Weber-Chrysochoou, Christina, Ye, Young-Min, Zalewska-Janowska, Anna, Zanichelli, Andrea, Zhao, Zuotao, Zhi, Yuxiang, Zuberbier, Torsten, Zwiener, Ricardo D., and Castaldo, Anthony

Subjects
Medizin
Published
2020

11. Definition, aims, and implementation of GA(2)LEN/HAEi Angioedema Centers of Reference and Excellence

Author

Maurer, Marcus Werner, Aberer Agondi, Rosana Al-Ahmad, Mona and Al-Nesf, Maryam Ali Ansotegui, Ignacio Arnaout, Rand and Arruda, Luisa Karla Asero, Riccardo Aygoeren-Puersue, Emel and Banerji, Aleena Bauer, Andrea Ben-Shoshan, Moshe Berardi, Alejandro Bernstein, Jonathan A. Betschel, Stephen and Bindslev-Jensen, Carsten Bizjak, Mojca Boccon-Gibod, Isabelle and Bork, Konrad Bouillet, Laurence Boysen, Henrik Balle and Brodszki, Nicholas Broesby-Olsen, Sigurd Busse, Paula and Buttgereit, Thomas Bygum, Anette Caballero, Teresa Campos, Regis A. Cancian, Mauro Cherrez-Ojeda, Ivan Cohn, Danny M. and Costa, Celia Craig, Timothy Criado, Paulo Ricardo and Criado, Roberta F. Csuka, Dorottya Dissemond, Joachim and Du-Thanh, Aurelie Ensina, Luis Felipe Ertas, Ragip Fabiani, Jose E. Fantini, Claudio Farkas, Henriette Ferrucci, Silvia Mariel Figueras-Nart, Ignasi Fili, Natalia L. Fomina, Daria and Fukunaga, Atsushi Gelincik, Asli Gimenez-Arnau, Ana and Godse, Kiran Gompels, Mark Goncalo, Margarida Gotua, Maia and Gower, Richard Grumach, Anete S. Guidos-Fogelbach, Guillermo and Hide, Michihiro Ilina, Natalia Inomata, Naoko Jakob, Thilo Josviack, Dario O. Kang, Hye-Ryun Kaplan, Allen and Kasperska-Zajac, Alicja Katelaris, Constance Kessel, Aharon and Kleinheinz, Andreas Kocaturk, Emek Kosnik, Mitja Krasowska, Dorota Kulthanan, Kanokvalai Kumaran, M. Sendhil Larco Sousa, Jose Ignacio Longhurst, Hilary J. Lumry, William and MacGinnitie, Andrew Magerl, Markus Makris, Michael P. and Malbran, Alejandro Marsland, Alexander Martinez-Saguer, Inmaculada Medina, Iris V. Meshkova, Raisa Metz, Martin and Nasr, Iman Nicolay, Jan Nishigori, Chikako Ohsawa, Isao and Ozyurt, Kemal Papadopoulos, Nikolaos G. Parisi, Claudio A. S. and Peter, Jonathan Grant Pfuetzner, Wolfgang Popov, Todor and Prior, Nieves Ramon, German D. Reich, Adam Reshef, Avner and Riedl, Marc A. Ritchie, Bruce Rockmann-Helmbach, Heike and Rudenko, Michael Salman, Andac Sanchez-Borges, Mario and Schmid-Grendelmeier, Peter Serpa, Faradiba S. Serra-Baldrich, Esther Sheikh, Farrukh R. Smith, William Soria, Angele and Staubach, Petra Steiner, Urs C. Stobiecki, Marcin Sussman, Gordon Tagka, Anna Thomsen, Simon Francis Treudler, Regina and Valle, Solange van Doorn, Martijn Varga, Lilian Vazquez, Daniel O. Wagner, Nicola Wang, Liangchun Weber-Chrysochoou, Christina Ye, Young-Min Zalewska-Janowska, Anna Zanichelli, Andrea Zhao, Zuotao Zhi, Yuxiang Zuberbier, Torsten and Zwiener, Ricardo D. Castaldo, Anthony

Published
2020

12. Definition, aims, and implementation of GA(2) LEN/HAEi Angioedema Centers of Reference and Excellence

Author

Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219), Maurer, Marcus; Werner, Aberer; Agondi, Rosana; Al-Ahmad, Mona; Al-Nesf, Maryam Ali; Ansotegui, Ignacio; Arnaout, Rand; Arruda, Luisa Karla; Asero, Riccardo; Aygoeren-Puersue, Emel; Banerji, Aleena; Bauer, Andrea; Ben-Shoshan, Moshe; Berardi, Alejandro; Bernstein, Jonathan A; Betschel, Stephen; Bindslev-Jensen, Carsten; Bizjak, Mojca; Boccon-Gibod, Isabelle; Bork, Konrad; Bouillet, Laurence; Boysen, Henrik Balle; Brodszki, Nicholas; Broesby-Olsen, Sigurd; Busse, Paula; Buttgereit, Thomas; Bygum, Anette; Caballero, Teresa; Campos, Regis A.; Cancian, Mauro; Cherrez-Ojeda, Ivan; Cohn, Danny M.; Costa, Celia; Craig, Timothy; Criado, Paulo Ricardo; Criado, Roberta F.; Csuka, Dorottya; Dissemond, Joachim; Du-Thanh, Aurelie; Ensina, Luis Felipe; Ertaş, Ragıp; Fabiani, Jose E.; Fantini, Claudio; Farkas, Henriette; Ferrucci, Silvia Mariel; Figueras-Nart, Ignasi; Fili, Natalia L.; Fomina, Daria; Fukunaga, Atsushi; Gelincik, Aslı; Gimenez-Arnau, Ana; Godse, Kiran; Gompels, Mark; Goncalo, Margarida; Gotua, Maia; Gower, Richard; Godse, Kiran; Gompels, Mark; Goncalo, Margarida; Gotua, Maia; Gower, Richard; Grumach, Anete S; Guidos-Fogelbach, Guillermo; Hide, Michihiro; Ilina, Natalia; Inomata, Naoko; Jakob, Thilo; Josviack, Dario O.; Kang, Hye-Ryun; Kaplan, Allen; Kasperska-Zajac, Alicja; Katelaris, Constance; Kessel, Aharon; Kleinheinz, Andreas; Kosnik, Mitja; Krasowska, Dorota; Kulthanan, Kanokvalai; Kumaran, M. Sendhil; Larco Sousa, Jose Ignacio; Longhurst, Hilary J.; Lumry, William; MacGinnitie, Andrew; Magerl, Markus; Makris, Michael P.; Malbran, Alejandro; Marsland, Alexander; Martinez-Saguer, Inmaculada; Medina, Iris V.; Meshkova, Raisa; Metz, Martin; Nasr, Iman; Nicolay, Jan; Nishigori, Chikako V.; Meshkova, Raisa; Metz, Martin; Nasr, Iman; Nicolay, Jan; Nishigori, Chikako; Ohsawa, Isao; Özyurt, Kemal; Papadopoulos, Nikolaos G.; Parisi, Claudio A. S.; Peter, Jonathan Grant; Pfuetzner, Wolfgang; Popov, Todor; Prior, Nieves; Ramon, German D.; Reich, Adam; Reshef, Avner; Rie, School of Medicine, Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219), Maurer, Marcus; Werner, Aberer; Agondi, Rosana; Al-Ahmad, Mona; Al-Nesf, Maryam Ali; Ansotegui, Ignacio; Arnaout, Rand; Arruda, Luisa Karla; Asero, Riccardo; Aygoeren-Puersue, Emel; Banerji, Aleena; Bauer, Andrea; Ben-Shoshan, Moshe; Berardi, Alejandro; Bernstein, Jonathan A; Betschel, Stephen; Bindslev-Jensen, Carsten; Bizjak, Mojca; Boccon-Gibod, Isabelle; Bork, Konrad; Bouillet, Laurence; Boysen, Henrik Balle; Brodszki, Nicholas; Broesby-Olsen, Sigurd; Busse, Paula; Buttgereit, Thomas; Bygum, Anette; Caballero, Teresa; Campos, Regis A.; Cancian, Mauro; Cherrez-Ojeda, Ivan; Cohn, Danny M.; Costa, Celia; Craig, Timothy; Criado, Paulo Ricardo; Criado, Roberta F.; Csuka, Dorottya; Dissemond, Joachim; Du-Thanh, Aurelie; Ensina, Luis Felipe; Ertaş, Ragıp; Fabiani, Jose E.; Fantini, Claudio; Farkas, Henriette; Ferrucci, Silvia Mariel; Figueras-Nart, Ignasi; Fili, Natalia L.; Fomina, Daria; Fukunaga, Atsushi; Gelincik, Aslı; Gimenez-Arnau, Ana; Godse, Kiran; Gompels, Mark; Goncalo, Margarida; Gotua, Maia; Gower, Richard; Godse, Kiran; Gompels, Mark; Goncalo, Margarida; Gotua, Maia; Gower, Richard; Grumach, Anete S; Guidos-Fogelbach, Guillermo; Hide, Michihiro; Ilina, Natalia; Inomata, Naoko; Jakob, Thilo; Josviack, Dario O.; Kang, Hye-Ryun; Kaplan, Allen; Kasperska-Zajac, Alicja; Katelaris, Constance; Kessel, Aharon; Kleinheinz, Andreas; Kosnik, Mitja; Krasowska, Dorota; Kulthanan, Kanokvalai; Kumaran, M. Sendhil; Larco Sousa, Jose Ignacio; Longhurst, Hilary J.; Lumry, William; MacGinnitie, Andrew; Magerl, Markus; Makris, Michael P.; Malbran, Alejandro; Marsland, Alexander; Martinez-Saguer, Inmaculada; Medina, Iris V.; Meshkova, Raisa; Metz, Martin; Nasr, Iman; Nicolay, Jan; Nishigori, Chikako V.; Meshkova, Raisa; Metz, Martin; Nasr, Iman; Nicolay, Jan; Nishigori, Chikako; Ohsawa, Isao; Özyurt, Kemal; Papadopoulos, Nikolaos G.; Parisi, Claudio A. S.; Peter, Jonathan Grant; Pfuetzner, Wolfgang; Popov, Todor; Prior, Nieves; Ramon, German D.; Reich, Adam; Reshef, Avner; Rie, and School of Medicine

Abstract

GA(2)LEN UCARE Network

Published
2020

14. Einsatz des ersten Biologikums in der Therapie des atopischen Ekzems unter real-life-Bedingungen: Ergebnisse des Deutschen Neurodermitis-Registers TREATgermany

Author

Abraham, Susanne, Haufe, Eva, Harder, Inken, Heratizadeh, Annice, Kleinheinz, Andreas, Wollenberg, Andreas, Weisshaar, Elke, Wiemers, Franca, Augustin, Matthias, Zink, Alexander, von Kiedrowski, Ralph, Worm, Margitta, Hilgers, Melanie, Pawlak, Mario, Fell, Isabel, Schäkel, Knut, Handrick, Christiane, Sticherling, Michael, Staubach-Renz, Petra, Asmussen, Andrea, Bell, Magnus, Schwarz, Beate, Beissert, Stefan, Biedermann, Tilo, Weidinger, Stephan, and Schmitt, Jochen

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Die Zulassung des ersten Biologikums zur Therapie der mittelschweren bis schweren atopischen Dermatitis (AD) eröffnet eine neue Therapieoption für Patienten, bei denen die Erkrankungsschübe und die Einschränkungen der gesundheitsbezogenen Lebensqualität durch äußerliche[zum vollständigen Text gelangen Sie über die oben angegebene URL], 18. Deutscher Kongress für Versorgungsforschung (DKVF)

Published
2019
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15. Blood transcriptome profiling identifies 2 candidate endotypes of atopic dermatitis

Author

Möbus, Lena, Rodriguez, Elke, Harder, Inken, Boraczynski, Nicole, Szymczak, Silke, Hübenthal, Matthias, Stölzl, Dora, Gerdes, Sascha, Kleinheinz, Andreas, Abraham, Susanne, Heratizadeh, Annice, Handrick, Christiane, Haufe, Eva, Werfel, Thomas, Schmitt, Jochen, and Weidinger, Stephan

Subjects
Adult, Gene Expression Profiling, Immunology, eosinophil signatures, Severity of Illness Index, Dermatitis, Atopic, blood transcriptome, endotypes, dupilumab, gene expression, Immunology and Allergy, Humans, RNA-Seq, Interleukin-5, Transcriptome, Atopic dermatitis
Abstract

Background Few studies have analyzed the bloodtranscriptomeinatopic dermatitis(AD). Objective We explored bloodtranscriptomicfeatures of moderate to severe AD. Methods Blood messengerRNA sequencingon 60 adults from the TREATgermany registry including 49 patients before and afterdupilumabtreatment, as well as from an independent cohort of 31 patients and 43 controls was performed. Patient clustering, differential expression, correlation and coexpression network analysis, and unsupervised learning were conducted. Results AD patients showed pronounced inflammatory expression signatures with increased myeloid and IL-5–related patterns, and clearly segregated into 2 distinct clusters, with striking differences in particular for transcripts involved ineosinophilsignaling. The eosinophil-highendotypeshowed a more pronounced global dysregulation, a positive correlation between disease activity and signatures related to IL-5 signaling, and strong correlations with several target proteins of antibodies or small molecules under development for AD. In contrast, the eosinophil-low endotype showed little transcriptomic dysregulation and no association between disease activity and gene expression. Clinical improvement with receipt of dupilumab was accompanied by a decrease ofinnate immune responsesand an increase of lymphocyte signatures including B-cell activation andnatural killer cellcomposition and/or function. The proportion of super responders was higher in the eosinophil-low endotype (32% vs 11%). Continued downregulation ofIL18RAP,IFNG,andgranzyme Ain the eosinophil-high endotype suggests a residual disturbance of natural killer cell function despite clinical improvement. Conclusion AD can be stratified intoeosinophilicand noneosinophilic endotypes; such stratification may be useful when assessing stratified trial designs and treatment strategies.

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16. Dupilumab but not cyclosporine treatment shifts the microbiome toward a healthy skin flora in patients with moderate‐to‐severe atopic dermatitis

Author

Hartmann, Jan, Moitinho‐Silva, Lucas, Sander, Nicole, Harder, Inken, Häsler, Robert, Rodriguez, Elke, Haufe, Eva, Kleinheinz, Andreas, Abraham, Susanne, Heratizadeh, Annice, Weisshaar, Elke, Schäkel, Knut, Handrick, Christiane, Augustin, Matthias, Wollenberg, Andreas, Staubach‐Renz, Petra, Ertner, Konstantin, Sticherling, Michael, Schwarz, Beate, Quist, Sven, Wiemers, Franca, Schenck, Florian, Wildberger, Julia, Tittmann, Lukas, Lieb, Wolfgang, Schmitt, Jochen, Werfel, Thomas, and Weidinger, Stephan

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17. Definition, aims, and implementation of GA [sup] 2 LEN/HAEi Angioedema Centers of Reference and Excellence

Author

Kemal Özyurt, Teresa Caballero, Aharon Kessel, Andrew J. MacGinnitie, Solange Oliveira Rodrigues Valle, Anthony J. Castaldo, Markus Magerl, Regis A. Campos, Adam Reich, Heike Röckmann-Helmbach, R. Y. Meshkova, Mario Sánchez-Borges, Richard G. Gower, Anna Zalewska-Janowska, Daria Fomina, Célia Costa, Allen P. Kaplan, Marc A. Riedl, Naoko Inomata, Avner Reshef, Alejandro Malbrán, Aurélie Du-Thanh, N. Prior, Hilary Longhurst, Margarida Gonçalo, Kiran Godse, Rosana Câmara Agondi, Andreas Kleinheinz, Inmaculada Martinez-Saguer, Mona Al-Ahmad, Thilo Jakob, Luis Felipe Ensina, José Ignacio Larco Sousa, Anna Tagka, Chikako Nishigori, Nicola Wagner, Hye Ryun Kang, Michael Makris, Nicholas Brodszki, Ricardo Dario Zwiener, Jan Nicolay, Alicja Kasperska-Zając, Iris V Medina, Ignacio J. Ansotegui, Marcin Stobiecki, Alejandro Berardi, Danny M. Cohn, Claudio A S Parisi, Angèle Soria, Torsten Zuberbier, Dario O. Josviack, E Serra-Baldrich, Jonathan A. Bernstein, Anette Bygum, Isao Ohsawa, Henriette Farkas, Iman Nasr, Thomas Buttgereit, Jonathan Peter, Carsten Bindslev-Jensen, Paulo Ricardo Criado, Wolfgang Pfützner, Natalia Fili, Silvia Mariel Ferrucci, Petra Staubach, Peter Schmid-Grendelmeier, M. Gotua, Marcus Maurer, Jose Fabiani, Gordon Sussman, A. Marsland, Konrad Bork, Andrea Zanichelli, Simon Francis Thomsen, Isabelle Boccon-Gibod, Mauro Cancian, German D. Ramon, Zuotao Zhao, Nikolaos G. Papadopoulos, Martijn B. A. van Doorn, Andrea Bauer, Kanokvalai Kulthanan, Claudio Fantini, Henrik Balle Boysen, Lilian Varga, Dorota Krasowska, Ana Giménez-Arnau, Werner Aberer, Ivan Cherrez-Ojeda, Roberta F. Criado, Constance H. Katelaris, Martin Metz, Riccardo Asero, Mitja Košnik, Stephen Betschel, M Sendhil Kumaran, Sigurd Broesby-Olsen, Moshe Ben-Shoshan, Rand Arnaout, Regina Treudler, Laurence Bouillet, Natalia Ilina, Maryam Ali Al-Nesf, Emek Kocatürk, Emel Aygören-Pürsün, William R. Lumry, Guillermo Guidos-Fogelbach, Yuxiang Zhi, Mark Gompels, Andac Salman, Christina Weber-Chrysochoou, Michihiro Hide, Young Min Ye, Aslı Gelincik, William B Smith, Timothy J. Craig, Bruce Ritchie, Daniel O. Vázquez, Mojca Bizjak, Atsushi Fukunaga, Ragıp Ertaş, Urs C. Steiner, Faradiba Sarquis Serpa, Farrukh R. Sheikh, Michael Rudenko, Paula J. Busse, Luisa Karla de Paula Arruda, Liangchun Wang, Todor A. Popov, Anete Sevciovic Grumach, Joachim Dissemond, Dorottya Csuka, Ignasi Figueras-Nart, Aleena Banerji, Tıp Fakültesi, Kemal Özyurt / 0000-0002-6913-8310, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Dermatology, Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219), Maurer, Marcus, Werner, Aberer, Agondi, Rosana, Al-Ahmad, Mona, Al-Nesf, Maryam Ali, Ansotegui, Ignacio, Arnaout, Rand, Arruda, Luisa Karla, Asero, Riccardo, Aygoeren-Puersue, Emel, Banerji, Aleena, Bauer, Andrea, Ben-Shoshan, Moshe, Berardi, Alejandro, Bernstein, Jonathan A, Betschel, Stephen, Bindslev-Jensen, Carsten, Bizjak, Mojca, Boccon-Gibod, Isabelle, Bork, Konrad, Bouillet, Laurence, Boysen, Henrik Balle, Brodszki, Nicholas, Broesby-Olsen, Sigurd, Busse, Paula, Buttgereit, Thomas, Bygum, Anette, Caballero, Teresa, Campos, Regis A., Cancian, Mauro, Cherrez-Ojeda, Ivan, Cohn, Danny M., Costa, Celia, Craig, Timothy, Criado, Paulo Ricardo, Criado, Roberta F., Csuka, Dorottya, Dissemond, Joachim, Du-Thanh, Aurelie, Ensina, Luis Felipe, Ertaş, Ragıp, Fabiani, Jose E., Fantini, Claudio, Farkas, Henriette, Ferrucci, Silvia Mariel, Figueras-Nart, Ignasi, Fili, Natalia L., Fomina, Daria, Fukunaga, Atsushi, Gelincik, Aslı, Gimenez-Arnau, Ana, Godse, Kiran, Gompels, Mark, Goncalo, Margarida, Gotua, Maia, Gower, Richard, Grumach, Anete S, Guidos-Fogelbach, Guillermo, Hide, Michihiro, Ilina, Natalia, Inomata, Naoko, Jakob, Thilo, Josviack, Dario O., Kang, Hye-Ryun, Kaplan, Allen, Kasperska-Zajac, Alicja, Katelaris, Constance, Kessel, Aharon, Kleinheinz, Andreas, Kosnik, Mitja, Krasowska, Dorota, Kulthanan, Kanokvalai, Kumaran, M. Sendhil, Larco Sousa, Jose Ignacio, Longhurst, Hilary J., Lumry, William, MacGinnitie, Andrew, Magerl, Markus, Makris, Michael P., Malbran, Alejandro, Marsland, Alexander, Martinez-Saguer, Inmaculada, Medina, Iris V., Meshkova, Raisa, Metz, Martin, Nasr, Iman, Nicolay, Jan, Nishigori, Chikako V., Nishigori, Chikako, Ohsawa, Isao, Özyurt, Kemal, Papadopoulos, Nikolaos G., Parisi, Claudio A. S., Peter, Jonathan Grant, Pfuetzner, Wolfgang, Popov, Todor, Prior, Nieves, Ramon, German D., Reich, Adam, Reshef, Avner, Riedl, Marc A., Ritchie, Bruce, Rockmann-Helmbach, Heike, Rudenko, Michael, Salman, Andaç, Sanchez-Borges, Mario, Schmid-Grendelmeier, Peter, Serpa, Faradiba S., Serra-Baldrich, Esther, Sheikh, Farrukh R., Smith, William, Soria, Angele, Staubach, Petra, Steiner, Urs C., Stobiecki, Marcin, Sussman, Gordon, Tagka, Anna, Thomsen, Simon Francis, Treudler, Regina, Valle, Solange, van Doorn, Martijn, Varga, Lilian, Vazquez, Daniel O., Wagner, Nicola, Wang, Liangchun, Weber-Chrysochoou, Christina, Ye, Young-Min, Zalewska-Janowska, Anna, Zanichelli, Andrea, Zhao, Zuotao, Zhi, Yuxiang, Zuberbier, Torsten, Zwiener, Ricardo D., Castaldo, Anthony, and School of Medicine

Subjects
medicine.medical_specialty, Edema angioneuròtic, Urticaria, media_common.quotation_subject, Immunology, education, GA2LEN, Angioedema, Center, Excellence, Management, urticaria, centres of reference and excelence, immune system diseases, center, medicine, Immunology and Allergy, Center (algebra and category theory), Angioneurotic edema, skin and connective tissue diseases, media_common, udc:616.1, business.industry, angioedema, humanities, referenčni centri odličnosti, Medicine, Allergy, Family medicine, excellence, medicine.symptom, business, Global Allergy and Asthma European Network, Urticària, management
Abstract

This document summarizes the aims of GA2 LEN/HAEi Angioedema Centers of Reference and Excellence (ACAREs) and elaborates the requirements that ACAREs must fulfill to become certified. It also provides (see Appendix S1) background information on GA2LEN and HAEi, including HAEi member organizations and regional patient advocates, on why we need an Angioedema Center of Reference and Excellence (ACARE) program and network, and on the accreditation and certification process, governance and funding, and on the interaction with other GA2LEN networks of centers of reference and excellence. The protocols, aims, requirements, and provisions related to becoming a certified CARE are based on (a) the experience of the GA2LEN UCARE network and (b) input from angioedema patients, general practitioners, and angioedema specialists.

Published
2020

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