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22 results on '"Kim, Min-Jong"'

11. A Study on the Actual Condition and Development Plan of Psychological Warfare in NORTH KOREA

Author

Kim Dae eun, Shim Jin sub, Kim Min jong, and Song Kyung jae

Subjects
Development plan, Politics, Political science, Political economy, Psychological Warfare, Sacrifice, Absolute advantage
Abstract

Psychological Warfare against NORTH KOREA with an absolute advantage from NORTH KOREA was sus-pended as it was used as a role of political sacrifice...

Published
2017

14. Gomisin M2 Inhibits Mast Cell-Mediated Allergic Inflammation via Attenuation of FcεRI-Mediated Lyn and Fyn Activation and Intracellular Calcium Levels

Author

Dhakal, Hima, primary, Lee, Soyoung, additional, Kim, Eun-Nam, additional, Choi, Jin Kyeong, additional, Kim, Min-Jong, additional, Kang, Jinjoo, additional, Choi, Young-Ae, additional, Baek, Moon-Chang, additional, Lee, Byungheon, additional, Lee, Hyun-Shik, additional, Shin, Tae-Yong, additional, Jeong, Gil-Saeng, additional, and Kim, Sang-Hyun, additional

Published
2019
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18. Elaeocarpusin Inhibits Mast Cell-Mediated Allergic Inflammation

Author

Kim, Min-Jong, primary, Kim, Yeon-Yong, additional, Choi, Young-Ae, additional, Baek, Moon-Chang, additional, Lee, Byungheon, additional, Park, Pil-Hoon, additional, Shin, Tae-Yong, additional, Kwon, Taeg Kyu, additional, Khang, Dongwoo, additional, and Kim, Sang-Hyun, additional

Published
2018
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20. 2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway

Author

Kim, Yeon-Yong, primary, Je, In-Gyu, additional, Kim, Min Jong, additional, Kang, Byeong-Cheol, additional, Choi, Young-Ae, additional, Baek, Moon-Chang, additional, Lee, Byungheon, additional, Choi, Jin Kyeong, additional, Park, Hae Ran, additional, Shin, Tae-Yong, additional, Lee, Soyoung, additional, Yoon, Seung-Bin, additional, Lee, Sang-Rae, additional, Khang, Dongwoo, additional, and Kim, Sang-Hyun, additional

Published
2016
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21. Ethanol Extract of Ampelopsis brevipedunculata Rhizomes Suppresses IgE-Mediated Mast Cell Activation and Anaphylaxis

Author

Park, Ji-Yeong, Kim, Min-Jong, Choi, Young-Ae, Woong Lee, Seung, Lee, Soyoung, Hyun Jang, Yong, and Kim, Sang-Hyun

Abstract

More than 20% of the world’s population suffers from allergic diseases, including allergic asthma, rhinitis, and atopic dermatitis that severely reduce the patient’s quality of life. The treatment of allergy has been developed, but there are still unmet needs. Ampelopsis brevipedunculata (Maxim.) Trautv. is a traditional medicinal herb with beneficial bioactivities, such as antioxidant, anti-hypertension, anti-viral, anti-mutagenic, and skin and liver (anti-hepatotoxic) protective actions. However, its anti-allergic effect has not been addressed. This study designed to investigate the pharmacological effect of an ethanol extract of A. brevipedunculata rhizomes (ABE) on mast cell and anaphylaxis models. For in vivo studies, we used ovalbumin-induced active systemic anaphylaxis (ASA) and immunoglobulin (Ig) E-mediated passive cutaneous anaphylaxis (PCA) models. In ASA model, oral administration of ABE (1, 10, and 100 mg/kg) attenuated the anaphylactic responses, such as hypothermia, serum histamine, and IgE productions. In PCA model, ABE also suppressed the plasma extravasation and swelling. The underlying mechanisms of action were identified in various mast cell types. In vitro, ABE (10, 30, and 60 µg/mL) inhibited the release of essential allergic mediators, such as histamine and β-hexosaminidase, in a concentration-dependent manner. ABE prevented the rapid increase in intracellular calcium levels induced by the DNP-HSA challenge. In addition, ABE downregulated the tumor necrosis factor-α and interleukin-4 by suppressing the activation of nuclear factor-κB. Collectively, this study is the first to identify the anti-allergic effect of ABE, suggesting that ABE is a promising candidate for treating allergic diseases.

Published
2024
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22. 2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway

Author

Kim, Yeon-Yong, Je, In-Gyu, Kim, Min Jong, Kang, Byeong-Cheol, Choi, Young-Ae, Baek, Moon-Chang, Lee, Byungheon, Choi, Jin Kyeong, Park, Hae Ran, Shin, Tae-Yong, Lee, Soyoung, Yoon, Seung-Bin, Lee, Sang-Rae, Khang, Dongwoo, and Kim, Sang-Hyun

Abstract

Mast cells are important effector cells in immunoglobulin (Ig) E-mediated allergic reactions such as asthma, atopic dermatitis and rhinitis. Vanillic acid, a natural product, has shown anti-oxidant and anti-inflammatory activities. In the present study, we investigated the anti-allergic inflammatory effects of ortho-vanillic acid (2-hydroxy-3-methoxybenzoic acid, o-VA) that was a derivative of vanillic acid isolated from Amomum xanthioides. In mouse anaphylaxis models, oral administration of o-VA (2, 10, 50 mg/kg) dose-dependently attenuated ovalbumin-induced active systemic anaphylaxis and IgE-mediated cutaneous allergic reactions such as hypothermia, histamine release, IgE production and vasodilation; administration of o-VA also suppressed the mast cell degranulator compound 48/80-induced anaphylaxis. In cultured mast cell line RBL-2H3 and isolated rat peritoneal mast cells in vitro, pretreatment with o-VA (1–100 μmol/L) dose-dependently inhibited DNP-HSA-induced degranulation of mast cells by decreasing the intracellular free calcium level, and suppressed the expression of pro-inflammatory cytokines TNF-α and IL-4. Pretreatment of RBL-2H3 cells with o-VA suppressed DNP-HSA-induced phosphorylation of Lyn, Syk, Akt, and the nuclear translocation of nuclear factor-κB. In conclusion, o-VA suppresses the mast cell-mediated allergic inflammatory response by blocking the signaling pathways downstream of high affinity IgE receptor (FcεRI) on the surface of mast cells.

Published
2017
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