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328 results on '"Kilbaugh, Todd"'

1. A novel translational bioinformatics framework for facilitating multimodal data analyses in preclinical models of neurological injury

Author

Gaudio, Hunter A., Padmanabhan, Viveknarayanan, Landis, William P., Silva, Luiz E. V., Slovis, Julia, Starr, Jonathan, Weeks, M. Katie, Widmann, Nicholas J., Forti, Rodrigo M., Laurent, Gerard H., Ranieri, Nicolina R., Mi, Frank, Degani, Rinat E., Hallowell, Thomas, Delso, Nile, Calkins, Hannah, Dobrzynski, Christiana, Haddad, Sophie, Kao, Shih-Han, Hwang, Misun, Shi, Lingyun, Baker, Wesley B., Tsui, Fuchiang, Morgan, Ryan W., Kilbaugh, Todd J., and Ko, Tiffany S.

Published
2024
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2. Early bolus epinephrine administration during pediatric cardiopulmonary resuscitation for bradycardia with poor perfusion: an ICU-resuscitation study

Author

O’Halloran, Amanda J., Reeder, Ron W., Berg, Robert A., Ahmed, Tageldin, Bell, Michael J., Bishop, Robert, Bochkoris, Matthew, Burns, Candice, Carcillo, Joseph A., Carpenter, Todd C., Dean, J. Michael, Diddle, J. Wesley, Federman, Myke, Fernandez, Richard, Fink, Ericka L., Franzon, Deborah, Frazier, Aisha H., Friess, Stuart H., Graham, Kathryn, Hall, Mark, Hehir, David A., Horvat, Christopher M., Huard, Leanna L., Kienzle, Martha F., Kilbaugh, Todd J., Maa, Tensing, Manga, Arushi, McQuillen, Patrick S., Meert, Kathleen L., Mourani, Peter M., Nadkarni, Vinay M., Naim, Maryam Y., Notterman, Daniel, Pollack, Murray M., Sapru, Anil, Schneiter, Carleen, Sharron, Matthew P., Srivastava, Neeraj, Tilford, Bradley, Topjian, Alexis A., Viteri, Shirley, Wessel, David, Wolfe, Heather A., Yates, Andrew R., Zuppa, Athena F., Sutton, Robert M., and Morgan, Ryan W.

Published
2024
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3. Effect of dimethyl fumarate on mitochondrial metabolism in a pediatric porcine model of asphyxia-induced in-hospital cardiac arrest

Author

Piel, Sarah, McManus, Meagan J., Heye, Kristina N., Beaulieu, Forrest, Fazelinia, Hossein, Janowska, Joanna I., MacTurk, Bryce, Starr, Jonathan, Gaudio, Hunter, Patel, Nisha, Hefti, Marco M., Smalley, Martin E., Hook, Jordan N., Kohli, Neha V., Bruton, James, Hallowell, Thomas, Delso, Nile, Roberts, Anna, Lin, Yuxi, Ehinger, Johannes K., Karlsson, Michael, Berg, Robert A., Morgan, Ryan W., and Kilbaugh, Todd J.

Published
2024
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9. Preliminary Research: Application of Non-Invasive Measure of Cytochrome c Oxidase Redox States and Mitochondrial Function in a Porcine Model of Carbon Monoxide Poisoning

Author

Lewis, Alistair, Forti, Rodrigo M., Alomaja, Oladunni, Mesaros, Clementina, Piel, Sarah, Greenwood, John C., Talebi, Fatima M., Mavroudis, Constantine D., Kelly, Matthew, Kao, Shih-Han, Shofer, Frances S., Ehinger, Johannes K., Kilbaugh, Todd J., Baker, Wesley B., and Jang, David H.

Published
2022
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10. Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine

Author

Padawer-Curry, Jonah A., Volk, Lindsay E., Mavroudis, Constantine D., Ko, Tiffany S., Morano, Vincent C., Busch, David R., Rosenthal, Tami M., Melchior, Richard W., Shade, Brandon C., Schiavo, Kellie L., Boorady, Timothy W., Schmidt, Alexander L., Andersen, Kristen N., Breimann, Jake S., Jahnavi, Jharna, Mensah-Brown, Kobina G., Yodh, Arjun G., Mascio, Christopher E., Kilbaugh, Todd J., Licht, Daniel J., White, Brian R., and Baker, Wesley B.

Published
2022
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13. Topical nitroglycerin to detect reversible microcirculatory dysfunction in patients with circulatory shock after cardiovascular surgery: an observational study

Author

Greenwood, John C., Talebi, Fatima M., Jang, David H., Spelde, Audrey E., Tonna, Joseph E., Gutsche, Jacob T., Horak, Jiri, Acker, Michael A., Kilbaugh, Todd J., Shofer, Frances S., Augoustides, John G. T., Bakker, Jan, Brenner, Jacob S., Muzykantov, Vladimir R., and Abella, Benjamin S.

Published
2022
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16. Carbon monoxide as a cellular protective agent in a swine model of cardiac arrest protocol

Author

Greenwood, John C., primary, Morgan, Ryan W., additional, Abella, Benjamin S., additional, Shofer, Frances S., additional, Baker, Wesley B., additional, Lewis, Alistair, additional, Ko, Tiffany S., additional, Forti, Rodrigo M., additional, Yodh, Arjun G., additional, Kao, Shih-Han, additional, Shin, Samuel S., additional, Kilbaugh, Todd J., additional, and Jang, David H., additional

Published
2024
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24. Correction to: Preliminary Research: Application of Non-Invasive Measure of Cytochrome c Oxidase Redox States and Mitochondrial Function in a Porcine Model of Carbon Monoxide Poisoning

Author

Lewis, Alistair, Forti, Rodrigo M., Alomaja, Oladunni, Mesaros, Clementina, Piel, Sarah, Greenwood, John C., Talebi, Fatima M., Mavroudis, Constantine D., Kelly, Matthew, Kao, Shih-Han, Shofer, Frances S., Ehinger, Johannes K., Kilbaugh, Todd J., Baker, Wesley B., and Jang, David H.

Published
2023
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26. Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2

Author

Behrens, Edward M., Diorio, Caroline, Henrickson, Sarah E., Vella, Laura A., McNerney, Kevin O., Chase, Julie, Burudpakdee, Chakkapong, Lee, Jessica H., Jasen, Cristina, Balamuth, Fran, Barrett, David M., Banwell, Brenda L., Bernt, Kathrin M., Blatz, Allison M., Chiotos, Kathleen, Fisher, Brian T., Fitzgerald, Julie C., Gerber, Jeffrey S., Gollomp, Kandace, Gray, Christopher, Grupp, Stephan A., Harris, Rebecca M., Kilbaugh, Todd J., Odom John, Audrey R., Lambert, Michele, Liebling, Emily J., Paessler, Michele E., Petrosa, Whitney, Phillips, Charles, Reilly, Anne F., Romberg, Neil D., Seif, Alix, Sesok-Pizzini, Deborah A., Sullivan, Kathleen E., Vardaro, Julie, Teachey, David T., and Bassiri, Hamid

Subjects
Immunodiagnosis -- Research, Pediatric research, Hospital patients -- Medical examination, COVID-19 -- Diagnosis, Pediatric multisystem inflammatory syndrome -- Diagnosis, Health care industry
Abstract

BACKGROUND. Initial reports from the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic described children as being less susceptible to coronavirus disease 2019 (COVID-19) than adults. Subsequently, a severe and novel pediatric disorder termed multisystem inflammatory syndrome in children (MIS-C) emerged. We report on unique hematologic and immunologic parameters that distinguish between COVID-19 and MIS-C and provide insight into pathophysiology. METHODS. We prospectively enrolled hospitalized patients with evidence of SARS-CoV-2 infection and classified them as having MIS-C or COVID-19. Patients with COVID-19 were classified as having either minimal or severe disease. Cytokine profiles, viral cycle thresholds (Cts), blood smears, and soluble C5b-9 values were analyzed with clinical data. RESULTS. Twenty patients were enrolled (9 severe COVID-19, 5 minimal COVID-19, and 6 MIS-C). Five cytokines (IFN- [gamma], IL-10, IL-6, IL-8, and TNF-[alpha]) contributed to the analysis. TNF-[alpha] and IL-10 discriminated between patients with MIS-C and severe COVID-19. The presence of burr cells on blood smears, as well as Cts, differentiated between patients with severe COVID-19 and those with MIS-C. CONCLUSION. Pediatric patients with SARS-CoV-2 are at risk for critical illness with severe COVID-19 and MIS-C. Cytokine profiling and examination of peripheral blood smears may distinguish between patients with MIS-C and those with severe COVID-19. FUNDING. Financial support for this project was provided by CHOP Frontiers Program Immune Dysregulation Team; National Institute of Allergy and Infectious Diseases; National Cancer Institute; the Leukemia and Lymphoma Society; Cookies for Kids Cancer; Alex's Lemonade Stand Foundation for Childhood Cancer; Children's Oncology Group; Stand UP 2 Cancer; Team Connor; the Kate Amato Foundations; Burroughs Wellcome Fund CAMS; the Clinical Immunology Society; the American Academy of Allergy, Asthma, and Immunology; and the Institute for Translational Medicine and Therapeutics., Introduction Initial reports from the coronavirus disease 2019 (COVID-19) pandemic indicated that children were less severely affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than adults (1-3). The [...]

Published
2020
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28. Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation

Author

Ko, Tiffany S., Mavroudis, Constantine D., Morgan, Ryan W., Baker, Wesley B., Marquez, Alexandra M., Boorady, Timothy W., Devarajan, Mahima, Lin, Yuxi, Roberts, Anna L., Landis, William P., Mensah-Brown, Kobina, Nadkarni, Vinay M., Berg, Robert A., Sutton, Robert M., Yodh, Arjun G., Licht, Daniel J., Guo, Wensheng, and Kilbaugh, Todd J.

Published
2021
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30. Chassis-based fiber-coupled optical probe design for reproducible quantitative diffuse optical spectroscopy measurements.

Author

Matlis, Giselle C., Zhang, Qihuang, Benson, Emilie J., Weeks, M. Katie, Andersen, Kristen, Jahnavi, Jharna, Lafontant, Alec, Breimann, Jake, Hallowell, Thomas, Lin, Yuxi, Licht, Daniel J., Yodh, Arjun G., Kilbaugh, Todd J., Forti, Rodrigo M., White, Brian R., Baker, Wesley B., Xiao, Rui, and Ko, Tiffany S.

Subjects
OPTICAL measurements, OPTICAL spectroscopy, OXYGEN saturation, ABSOLUTE value
Abstract

Advanced optical neuromonitoring of cerebral hemodynamics with hybrid diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) methods holds promise for non-invasive characterization of brain health in critically ill patients. However, the methods' fiber-coupled patient interfaces (probes) are challenging to apply in emergent clinical scenarios that require rapid and reproducible attachment to the head. To address this challenge, we developed a novel chassis-based optical probe design for DOS/DCS measurements and validated its measurement accuracy and reproducibility against conventional, manually held measurements of cerebral hemodynamics in pediatric swine (n = 20). The chassis-based probe design comprises a detachable fiber housing which snaps into a 3D-printed, circumferential chassis piece that is secured to the skin. To validate its reproducibility, eight measurement repetitions of cerebral tissue blood flow index (BFI), oxygen saturation (StO2), and oxy-, deoxy- and total hemoglobin concentration were acquired at the same demarcated measurement location for each pig. The probe was detached after each measurement. Of the eight measurements, four were acquired by placing the probe into a secured chassis, and four were visually aligned and manually held. We compared the absolute value and intra-subject coefficient of variation (CV) of chassis versus manual measurements. No significant differences were observed in either absolute value or CV between chassis and manual measurements (p > 0.05). However, the CV for BFI (mean ± SD: manual, 19.5% ± 9.6; chassis, 19.0% ± 10.8) was significantly higher than StO2 (manual, 5.8% ± 6.7; chassis, 6.6% ± 7.1) regardless of measurement methodology (p<0.001). The chassis-based DOS/DCS probe design facilitated rapid probe attachment/re-attachment and demonstrated comparable accuracy and reproducibility to conventional, manual alignment. In the future, this design may be adapted for clinical applications to allow for non-invasive monitoring of cerebral health during pediatric critical care. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Mitochondrial antioxidants abate SARS-COV-2 pathology in mice.

Author

Guarnieri, Joseph W., Lie, Timothy, Soto Albrecht, Yentli E., Hewin, Peter, Jurado, Kellie A., Widjaja, Gabrielle A., Yi Zhu, McManus, Meagan J., Kilbaugh, Todd J., Keith, Kelsey, Potluri, Prasanth, Taylor, Deanne, Angelin, Alessia, Murdock, Deborah G., and Wallace, Douglas C.

Subjects
SARS-CoV-2, ANGIOTENSIN converting enzyme, MITOCHONDRIAL DNA, VIRAL proteins, GENE expression
Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection inhibits mito-chondrial oxidative phosphorylation (OXPHOS) and elevates mitochondrial reactive oxygen species (ROS, mROS) which activates hypoxia-inducible factor-1alpha (HIF-1a), shifting metabolism toward glycolysis to drive viral biogenesis but also causing the release of mitochondrial DNA (mtDNA) and activation of innate immunity. To determine whether mitochondrially targeted antioxidants could mitigate these viral effects, we challenged mice expressing human angiotensin-converting enzyme 2 (ACE2) with SARS-CoV-2 and intervened using transgenic and pharmacological mitochondrially targeted catalytic antioxidants. Transgenic expression of mitochondrially targeted catalase (mCAT) or systemic treatment with EUK8 decreased weight loss, clinical severity, and circulating levels of mtDNA; as well as reduced lung levels of HIF-1α, viral proteins, and inflammatory cytokines. RNA-sequencing of infected lungs revealed that mCAT and Eukarion 8 (EUK8) up-regulated OXPHOS gene expression and down-regulated HIF-1α and its target genes as well as innate immune gene expression. These data demonstrate that SARS-CoV-2 pathology can be mitigated by catalytically reducing mROS, potentially providing a unique host-directed pharmacological therapy for COVID-19 which is not subject to viral mutational resistance. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Normoxic Management during Cardiopulmonary Bypass Does Not Reduce Cerebral Mitochondrial Dysfunction in Neonatal Swine.

Author

Aronowitz, Danielle I., Geoffrion, Tracy R., Piel, Sarah, Morton, Sarah R., Starr, Jonathan, Melchior, Richard W., Gaudio, Hunter A., Degani, Rinat, Widmann, Nicholas J., Weeks, M. Katie, Ranieri, Nicolina R., Benson, Emilie, Ko, Tiffany S., Licht, Daniel J., Hefti, Marco, Gaynor, J. William, Kilbaugh, Todd J., and Mavroudis, Constantine D.

Subjects
OXYGEN consumption, CARDIOPULMONARY bypass, REACTIVE oxygen species, MITOCHONDRIA, SWINE, HEMODYNAMIC monitoring
Abstract

Optimal oxygen management during pediatric cardiopulmonary bypass (CPB) is unknown. We previously demonstrated an increase in cortical mitochondrial reactive oxygen species and decreased mitochondrial function after CPB using hyperoxic oxygen management. This study investigates whether controlled oxygenation (normoxia) during CPB reduces cortical mitochondrial dysfunction and oxidative injury. Ten neonatal swine underwent three hours of continuous CPB at 34 °C (flow > 100 mL/kg/min) via cervical cannulation targeting a partial pressure of arterial oxygen (PaO2) goal < 150 mmHg (normoxia, n = 5) or >300 mmHg (hyperoxia, n = 5). The animals underwent continuous hemodynamic monitoring and serial arterial blood sampling. Cortical microdialysate was serially sampled to quantify the glycerol concentration (represents neuronal injury) and lactate-to-pyruvate ratio (represents bioenergetic dysfunction). The cortical tissue was analyzed via high-resolution respirometry to quantify mitochondrial oxygen consumption and reactive oxygen species generation, and cortical oxidized protein carbonyl concentrations were quantified to assess for oxidative damage. Serum PaO2 was higher in hyperoxia animals throughout CPB (p < 0.001). There were no differences in cortical glycerol concentration between groups (p > 0.2). The cortical lactate-to-pyruvate ratio was modestly elevated in hyperoxia animals (p < 0.03) but the values were not clinically significant (<30). There were no differences in cortical mitochondrial respiration (p = 0.48), protein carbonyls (p = 0.74), or reactive oxygen species generation (p = 0.93) between groups. Controlled oxygenation during CPB does not significantly affect cortical mitochondrial function or oxidative injury in the acute setting. Further evaluation of the short and long-term effects of oxygen level titration during pediatric CPB on cortical tissue and other at-risk brain regions are needed, especially in the presence of cyanosis. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Diffuse Optical Monitoring of Cerebral Hemodynamics and Oxygen Metabolism during and after Cardiopulmonary Bypass: Hematocrit Correction and Neurological Vulnerability

Author

Benson, Emilie J., primary, Aronowitz, Danielle I., additional, Forti, Rodrigo M., additional, Lafontant, Alec, additional, Ranieri, Nicolina R., additional, Starr, Jonathan P., additional, Melchior, Richard W., additional, Lewis, Alistair, additional, Jahnavi, Jharna, additional, Breimann, Jake, additional, Yun, Bohyun, additional, Laurent, Gerard H., additional, Lynch, Jennifer M., additional, White, Brian R., additional, Gaynor, J. William, additional, Licht, Daniel J., additional, Yodh, Arjun G., additional, Kilbaugh, Todd J., additional, Mavroudis, Constantine D., additional, Baker, Wesley B., additional, and Ko, Tiffany S., additional

Published
2023
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38. Investigation of Cerebral Mitochondrial Injury in a Porcine Survivor Model of Carbon Monoxide Poisoning

Author

Mavroudis, Constantine D., primary, Lewis, Alistair, additional, Greenwood, John C., additional, Kelly, Matthew, additional, Ko, Tiffany S., additional, Forti, Rodrigo M., additional, Shin, Samuel S., additional, Shofer, Frances S., additional, Ehinger, Johannes K., additional, Baker, Wesley B., additional, Kilbaugh, Todd J., additional, and Jang, David H., additional

Published
2023
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43. Exploring the Therapeutic Potential of Phosphorylated Cis-Tau Antibody in a Pig Model of Traumatic Brain Injury

Author

Shin, Samuel S., primary, Mazandi, Vanessa M., additional, Schneider, Andrea L. C., additional, Morton, Sarah, additional, Starr, Jonathan P., additional, Weeks, M. Katie, additional, Widmann, Nicholas J., additional, Jang, David H., additional, Kao, Shih-Han, additional, Ahlijanian, Michael K., additional, and Kilbaugh, Todd J., additional

Published
2023
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44. Non-invasive optical neuromonitoring of the temperature-dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine

Author

Ko, Tiffany S, Mavroudis, Constantine D, Baker, Wesley B, Morano, Vincent C, Mensah-Brown, Kobina, Boorady, Timothy W, Schmidt, Alexander L, Lynch, Jennifer M, Busch, David R, Gentile, Javier, Bratinov, George, Lin, Yuxi, Jeong, Sejin, Melchior, Richard W, Rosenthal, Tami M, Shade, Brandon C, Schiavo, Kellie L, Xiao, Rui, Gaynor, J William, Yodh, Arjun G, Kilbaugh, Todd J, and Licht, Daniel J

Published
2020
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46. Non-invasive diffuse optical monitoring of cerebral physiology in an adult swine-model of impact traumatic brain injury

Author

Forti, Rodrigo, primary, Hobson, Lucas, additional, Benson, Emilie, additional, Ko, Tiffany, additional, Ranieri, Nicolina, additional, Laurent, Gerard, additional, Weeks, M Katie, additional, Widmann, Nicholas, additional, Morton, Sarah, additional, Davis, Anthony, additional, Sueishi, Takayuki, additional, Lin, Yuxi, additional, Wulwick, Karli, additional, Fagan, Nicholas, additional, Shin, Samuel, additional, Kao, Shih-Han, additional, Licht, Daniel, additional, White, Brian, additional, Kilbaugh, Todd, additional, Yodh, Arjun, additional, and Baker, Wesley, additional

Published
2023
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47. Pediatric Extracorporeal Cardiopulmonary Resuscitation: Development of a Porcine Model and the Influence of Cardiopulmonary Resuscitation Duration on Brain Injury

Author

Slovis, Julia C., primary, Volk, Lindsay, additional, Mavroudis, Constantine, additional, Hefti, Marco, additional, Landis, William P., additional, Roberts, Anna L., additional, Delso, Nile, additional, Hallowell, Thomas, additional, Graham, Kathryn, additional, Starr, Jonathan, additional, Lin, Yuxi, additional, Melchior, Richard, additional, Nadkarni, Vinay, additional, Sutton, Robert M., additional, Berg, Robert A., additional, Piel, Sarah, additional, Morgan, Ryan W., additional, and Kilbaugh, Todd J., additional

Published
2023
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50. Correction to: Preliminary Research: Application of Non-Invasive Measure of Cytochrome c Oxidase Redox States and Mitochondrial Function in a Porcine Model of Carbon Monoxide Poisoning

Author

Lewis, Alistair, primary, Forti, Rodrigo M., additional, Alomaja, Oladunni, additional, Mesaros, Clementina, additional, Piel, Sarah, additional, Greenwood, John C., additional, Talebi, Fatima M., additional, Mavroudis, Constantine D., additional, Kelly, Matthew, additional, Kao, Shih-Han, additional, Shofer, Frances S., additional, Ehinger, Johannes K., additional, Kilbaugh, Todd J., additional, Baker, Wesley B., additional, and Jang, David H., additional

Published
2022
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