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2. First World Consensus Conference on pancreas transplantation: Part II – recommendations

Author

Boggi, Ugo, Vistoli, Fabio, Andres, Axel, Arbogast, Helmut P., Badet, Lionel, Baronti, Walter, Bartlett, Stephen T., Benedetti, Enrico, Branchereau, Julien, Burke, George W., 3rd, Buron, Fanny, Caldara, Rossana, Cardillo, Massimo, Casanova, Daniel, Cipriani, Federica, Cooper, Matthew, Cupisti, Adamasco, Davide, Josè, Drachenberg, Cinthia, de Koning, Eelco J.P., Ettorre, Giuseppe Maria, Fernandez Cruz, Laureano, Fridell, Jonathan A., Friend, Peter J., Furian, Lucrezia, Gaber, Osama A., Gruessner, Angelika C., Gruessner, Rainer W.G., Gunton, Jenny E., Han, Duck-Jong, Iacopi, Sara, Kauffmann, Emanuele Federico, Kaufman, Dixon, Kenmochi, Takashi, Khambalia, Hussein A., Lai, Quirino, Langer, Robert M., Maffi, Paola, Marselli, Lorella, Menichetti, Francesco, Miccoli, Mario, Mittal, Shruti, Morelon, Emmanuel, Napoli, Niccolò, Neri, Flavia, Oberholzer, Jose, Odorico, Jon S., Öllinger, Robert, Oniscu, Gabriel, Orlando, Giuseppe, Ortenzi, Monica, Perosa, Marcelo, Perrone, Vittorio Grazio, Pleass, Henry, Redfield, Robert R., Ricci, Claudio, Rigotti, Paolo, Paul Robertson, R., Ross, Lainie F., Rossi, Massimo, Saudek, Frantisek, Scalea, Joseph R., Schenker, Peter, Secchi, Antonio, Socci, Carlo, Sousa Silva, Donzilia, Squifflet, Jean Paul, Stock, Peter G., Stratta, Robert J., Terrenzio, Chiara, Uva, Pablo, Watson, Christopher J.E., White, Steven A., Marchetti, Piero, Kandaswamy, Raja, and Berney, Thierry

Published
2021
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3. Association between a polymorphic variant in the CDKN2B-AS1/ANRIL gene and pancreatic cancer risk

Author

Giaccherini, Matteo, Farinella, Riccardo, Gentiluomo, Manuel, Mohelnikova-Duchonova, Beatrice, Kauffmann, Emanuele Federico, Palmeri, Matteo, Uzunoglu, Faik, Soucek, Pavel, Petrauskas, Dalius, Cavestro, Giulia Martina, Zykus, Romanas, Carrara, Silvia, Pezzilli, Raffaele, Puzzono, Marta, Szentesi, Andrea, Neoptolemos, John, Archibugi, Livia, Palmieri, Orazio, Milanetto, Anna Caterina, Capurso, Gabriele, van Eijck, Casper H.J., Stocker, Hannah, Lawlor, Rita T., Vodicka, Pavel, Lovecek, Martin, Izbicki, Jakob R., Perri, Francesco, Kupcinskaite-Noreikiene, Rita, Götz, Mara, Kupcinskas, Juozas, Hussein, Tamás, Hegyi, Péter, Busch, Olivier R., Hackert, Thilo, Mambrini, Andrea, Brenner, Hermann, Lucchesi, Maurizio, Basso, Daniela, Tavano, Francesca, Schöttker, Ben, Vanella, Giuseppe, Bunduc, Stefania, Petrányi, Ágota, Landi, Stefano, Morelli, Luca, Canzian, Federico, Campa, Daniele, Giaccherini, Matteo, Farinella, Riccardo, Gentiluomo, Manuel, Mohelnikova-Duchonova, Beatrice, Kauffmann, Emanuele Federico, Palmeri, Matteo, Uzunoglu, Faik, Soucek, Pavel, Petrauskas, Dalius, Cavestro, Giulia Martina, Zykus, Romanas, Carrara, Silvia, Pezzilli, Raffaele, Puzzono, Marta, Szentesi, Andrea, Neoptolemos, John, Archibugi, Livia, Palmieri, Orazio, Milanetto, Anna Caterina, Capurso, Gabriele, van Eijck, Casper H.J., Stocker, Hannah, Lawlor, Rita T., Vodicka, Pavel, Lovecek, Martin, Izbicki, Jakob R., Perri, Francesco, Kupcinskaite-Noreikiene, Rita, Götz, Mara, Kupcinskas, Juozas, Hussein, Tamás, Hegyi, Péter, Busch, Olivier R., Hackert, Thilo, Mambrini, Andrea, Brenner, Hermann, Lucchesi, Maurizio, Basso, Daniela, Tavano, Francesca, Schöttker, Ben, Vanella, Giuseppe, Bunduc, Stefania, Petrányi, Ágota, Landi, Stefano, Morelli, Luca, Canzian, Federico, and Campa, Daniele

Abstract

Genes carrying high-penetrance germline mutations may also be associated with cancer susceptibility through common low-penetrance genetic variants. To increase the knowledge on genetic pancreatic ductal adenocarcinoma (PDAC) aetiology, the common genetic variability of PDAC familial genes was analysed in our study. We conducted a multiphase study analysing 7745 single nucleotide polymorphisms (SNPs) from 29 genes reported to harbour a high-penetrance PDAC-associated mutation in at least one published study. To assess the effect of the SNPs on PDAC risk, a total of 14 666 PDAC cases and 221 897 controls across five different studies were analysed. The T allele of the rs1412832 polymorphism, that is situated in the CDKN2B-AS1/ANRIL, showed a genome-wide significant association with increased risk of developing PDAC (OR = 1.11, 95% CI = 1.07-1.15, P = 5.25 × 10−9). CDKN2B-AS1/ANRIL is a long noncoding RNA, situated in 9p21.3, and regulates many target genes, among which CDKN2A (p16) that frequently shows deleterious somatic and germline mutations and deregulation in PDAC. Our results strongly support the role of the genetic variability of the 9p21.3 region in PDAC aetiopathogenesis and highlight the importance of secondary analysis as a tool for discovering new risk loci in complex human diseases.

Published
2023

4. The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer

Author

Daniele Campa, Manuel Gentiluomo, Angelika Stein, Mateus Nóbrega Aoki, Martin Oliverius, Ludmila Vodičková, Krzysztof Jamroziak, George Theodoropoulos, Claudio Pasquali, William Greenhalf, Paolo Giorgio Arcidiacono, Faik Uzunoglu, Raffaele Pezzilli, Claudio Luchini, Marta Puzzono, Martin Loos, Matteo Giaccherini, Verena Katzke, Andrea Mambrini, Edita Kiudeliene, Kauffmann Emanuele Federico, Julia Johansen, Tamás Hussein, Beatrice Mohelnikova-Duchonova, Casper H.J. van Eijck, Hermann Brenner, Riccardo Farinella, Juan Sainz Pérez, Martin Lovecek, Markus W. Büchler, Viktor Hlavac, Jakob R. Izbicki, Thilo Hackert, Roger Chammas, Alessandro Zerbi, Rita Lawlor, Alessio Felici, Mara Götz, Gabriele Capurso, Laura Ginocchi, Maria Gazouli, Juozas Kupcinskas, Giulia Martina Cavestro, Pavel Vodicka, Stefania Moz, John P. Neoptolemos, Lumir Kunovsky, Stig E. Bojesen, Silvia Carrara, Domenica Gioffreda, Egidijus Morkunas, Olga Abian, Stefania Bunduc, Daniela Basso, Ugo Boggi, Barbara Wlodarczyk, Andrea Szentesi, Giuseppe Vanella, Inna Chen, Maarten F. Bijlsma, Vytautas Kiudelis, Stefano Landi, Ben Schöttker, Chiara Corradi, Nathalia Giese, Rudolf Kaaks, Giulia Peduzzi, Péter Hegyi, Luca Morelli, Niccolò Furbetta, Pavel Soucek, Anna Latiano, Renata Talar-Wojnarowska, Sidsel C. Lindgaard, Frederike Dijk, Anna Caterina Milanetto, Francesca Tavano, Klara Cervena, Bálint Erőss, Sabrina G. Testoni, Judith H.E. Verhagen-Oldenampsen, Ewa Małecka-Wojciesko, Eithne Costello, Roberto Salvia, Evaristo Maiello, Stefano Ermini, Cosimo Sperti, Bernd Holleczek, Francesco Perri, Jurgita Skieceviciene, Livia Archibugi, Maurizio Lucchesi, Cosmeri Rizzato, and Federico Canzian

Subjects
chronic pancreatitis, Pancreatic cancer, Pancreatic ductal adenocarcinoma, Pancreatic neuroendocrine tumors, Intraductal papillary mucinous neoplasms, Chronic pancreatitis, Genetic epidemiology, Consortium, genetic epidemiology, pancreatic neuroendocrine tumors, SDG 3 - Good Health and Well-being, Oncology, pancreatic ductal adenocarcinoma, consortium, Hematology, intraductal papillary mucinous neoplasms
Abstract

Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.

Published
2023

5. The MIS-COVID-AGICT Study: Trend of Minimally Invasive Surgery for Gastrointestinal Cancer Treatment During the First Waves of the COVID-19 Pandemic in Italy. Subgroup Analysis from the COVID-AGICT Study: COVID-19 and Advanced Gastrointestinal Cancer Surgical Treatment

Author

Giuliani, Giuseppe, Coletta, Diego, Guerra, Francesco, Esposito, Sofia, Esposito, Alessandro, De Pastena, Matteo, Rega, Daniela, Delrio, Paolo, La Raja, Carlotta, Spinelli, Antonino, Massaron, Simonetta, De Nardi, Paola, Kauffmann, Emanuele Federico, Boggi, Ugo, Deidda, Simona, Zorcolo, Luigi, Marano, Alessandra, Borghi, Felice, Piccoli, Micaela, Depalma, Norma, D'Ugo, Stefano, Spampinato, Marcello, Cozzani, Federico, Del Rio, Paolo, Marcellinaro, Rosa, Carlini, Massimo, De Rosa, Raffaele, Scabini, Stefano, Maiello, Fabio, Polastri, Roberto, Turri, Giulia, Pedrazzani, Corrado, Zese, Monica, Parini, Dario, and Coratti, Andrea

Subjects
robotic, COVID-19, laparoscopic, minimally invasive surgery
Published
2023

7. Associations between pancreatic expression quantitative traits and risk of pancreatic ductal adenocarcinoma

Author

Pistoni, Laura Gentiluomo, Manuel Lu, Ye de Maturana, Evangelina Lopez Hlavac, Viktor Vanella, Giuseppe Darvasi, Erika Milanetto, Anna Caterina Oliverius, Martin Vashist, Yogesh Di Leo, Milena Mohelnikova-Duchonova, Beatrice and Talar-Wojnarowska, Renata Gheorghe, Cristian Petrone, Maria Chiara Strobel, Oliver Arcidiacono, Paolo Giorgio Vodickova, Ludmila Szentesi, Andrea Capurso, Gabriele Gajdan, Laszlo and Malleo, Giuseppe Theodoropoulos, George E. Basso, Daniela and Soucek, Pavel Brenner, Hermann Lawlor, Rita T. Morelli, Luca Ivanauskas, Audrius Kauffmann, Emanuele Federico and Macauda, Angelica Gazouli, Maria Archibugi, Livia Nentwich, Michael Cavestro, Giulia Martina Vodicka, Pavel Landi, Stefano Tavano, Francesca Sperti, Cosimo Hackert, Thilo and Kupcinskas, Juozas Pezzilli, Raffaele Andriulli, Angelo and Pollina, Luca Kreivenaite, Edita Gioffreda, Domenica and Jamroziak, Krzysztof Hegyi, Peter Izbicki, Jakob R. Testoni, Sabrina Gloria Giulia Zuppardo, Raffaella Alessia Bozzato, Dania and Neoptolemos, John P. Malats, Nuria Canzian, Federico and Campa, Daniele Lovecek, Martin

Subjects
endocrine system diseases
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Its poor prognosis is predominantly due to the fact that most patients remain asymptomatic until the disease reaches an advanced stage, alongside the lack of early markers and screening strategies. A better understanding of PDAC risk factors is essential for the identification of groups at high risk in the population. Genome-wide association studies (GWAS) have been a powerful tool for detecting genetic variants associated with complex traits, including pancreatic cancer. By exploiting functional and GWAS data, we investigated the associations between polymorphisms affecting gene function in the pancreas (expression quantitative trait loci, eQTLs) and PDAC risk. In a two-phase approach, we analysed 13 713 PDAC cases and 43 784 controls and identified a genome-wide significant association between the A allele of the rs2035875 polymorphism and increased PDAC risk (P = 7.14 x 10(-10)). This allele is known to be associated with increased expression in the pancreas of the keratin genes KRT8 and KRT18, whose increased levels have been reported to correlate with various tumour cell characteristics. Additionally, the A allele of the rs789744 variant was associated with decreased risk of developing PDAC (P = 3.56 x 10(-6)). This single nucleotide polymorphism is situated in the SRGAP1 gene and the A allele is associated with higher expression of the gene, which in turn inactivates the cyclin-dependent protein 42 (CDC42) gene expression, thus decreasing the risk of PDAC. In conclusion, we present here a functional-based novel PDAC risk locus and an additional strong candidate supported by significant associations and plausible biological mechanisms.

Published
2021

8. 134 ROBOT-ASSISTED PANCREATECTOMIES: BO17–01

Author

Belluomini, Mario Antonio, Lio, NelideDe, Signori, Stefano, Costa, Francesca, Perrone, Vittorio Grazio, Vistoli, Fabio, Kauffmann, Emanuele Federico, Napoli, Niccolò, and Boggi, Ugo

Published
2014

9. First world consensus conference on pancreas transplantation: Part I—Methods and results of literature search

Author

Boggi, Ugo, Vistoli, Fabio, Marchetti, Piero, Kandaswamy, Raja, Berney, Thierry, Andres, Axel, Arbogast, Helmut P., Badet, Lionel, Baronti, Walter, Bartlett, Stephen T., Benedetti, Enrico, Branchereau, Julien, Burke, George W. 3rd, Buron, Fanny, Caldara, Rossana, Cardillo, Massimo, Casanova, Daniel, Cipriani, Federica, Cooper, Matthew, Cupisti, Adamasco, Koning, Eelco J.P., Davide, José, Drachenberg, Cinthia, Ettorre, Giuseppe Maria, Fernandez Cruz, Laureano, Fridell, Jonathan A., Friend, Peter J., Furian, Lucrezia, Gaber, Osama A., Gruessner, Angelika C., Gruessner, Rainer W.G., Gunton, Jenny E., Han, Duck‐Jong, Iacopi, Sara, Kauffmann, Emanuele Federico, Kaufman, Dixon, Kenmochi, Takashi, Khambalia, Hussein A., Lai, Quirino, Langer, Robert M., Maffi, Paola, Marselli, Lorella, Menichetti, Francesco, Miccoli, Mario, Mittal, Shruti, Morelon, Emmanuel, Napoli, Niccolò, Neri, Flavia, Oberholzer, Jose, Odorico, Jon S., Öllinger, Robert, Oniscu, Gabriel, Orlando, Giuseppe, Ortenzi, Monica, Perosa, Marcelo, Perrone, Vittorio Grazio, Redfield, Robert R., Ricci, Claudio, Rigotti, Paolo, Robertson, R. Paul, Ross, Lainie F., Rossi, Massimo, Saudek, Frantisek, Scalea, Joseph R., Schenker, Peter, Secchi, Antonio, Socci, Carlo, Sousa Silva, Donzilia, Squifflet, Jean Paul, Stock, Peter G., Stratta, Robert J., Terrenzio, Chiara, Uva, Pablo, Watson, Christopher C. E., and White, Steven A.

Abstract

Comprehensive evidence‐based guidelines for the practice of pancreas transplantation are yet to be established. The First World Consensus Conference on Pancreas Transplantation was convened for this purpose. A steering committee selected the participants and defined the questions to be addressed. A group of literature reviewers identified 597 studies to be included in summaries for guidelines production. Expert groups formulated the first draft of recommendations. Two rounds of discussion and voting occurred online, using the Delphi method (agreement rate ≥85%). After each round, critical responses of experts were reviewed, and recommendations were amended accordingly. Recommendations were finalized after live discussions. Each session was preceded by expert presentations and a summary of results of systematic literature review. Up to three voting rounds were allowed for each recommendation. To avoid potential conflicts of interest, deliberations on issues regarding the impact of pancreas transplantation on the management of diabetes were conducted by an independent jury. Recommendations on technical issues were determined by experts and validated using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument. Quality of evidence was assessed using the Scottish Intercollegiate Guidelines Network (SIGN) methodology. Each recommendation received a GRADE rating (Grading of Recommendations, Assessment, Development and Evaluations). This article presents the results of literature search and the methods used to provide evidence‐based guidelines for the practice of pancreas transplantation at the First World Consensus Conference on Pancreas Transplantation.

Published
2021
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10. First World Consensus Conference on Pancreas Transplantation: Part II - recommendations

Author

Jonathan A. Fridell, Gabriel C. Oniscu, Marcelo Perosa, Quirino Lai, Helmut Arbogast, Jean-Paul Squifflet, Paola Maffi, Axel Andres, Jose Oberholzer, Claudio Ricci, Eelco J.P. de Koning, Daniel Casanova, Osama Gaber, Stephen T. Bartlett, Giuseppe Orlando, Ugo Boggi, Peter Schenker, Giuseppe Maria Ettorre, Piero Marchetti, R. Paul Robertson, Jenny E. Gunton, Steven A. White, Sara Iacopi, Raja Kandaswamy, Robert Öllinger, Pablo Uva, Francesco Menichetti, Rainer W.G. Gruessner, Dixon B. Kaufman, Lainie Friedman Ross, Cinthia B. Drachenberg, Paolo Rigotti, Robert R. Redfield, José Davide, Joseph R. Scalea, Mario Miccoli, Fanny Buron, Chiara Terrenzio, Duck Jong Han, Vittorio Perrone, Henry Pleass, Laureano Fernandez Cruz, Hussein A. Khambalia, Walter Baronti, Lucrezia Furian, Thierry Berney, Donzilia Sousa Silva, Robert Langer, Emmanuel Morelon, Peter G. Stock, Niccolò Napoli, Peter J. Friend, Robert J. Stratta, Fabio Vistoli, Matthew Cooper, Massimo Cardillo, Shruti Mittal, Frantisek Saudek, Adamasco Cupisti, Federica Cipriani, Emanuele Federico Kauffmann, Lionel Badet, Monica Ortenzi, Massimo Rossi, Lorella Marselli, Christopher J.E. Watson, Enrico Benedetti, George W. Burke, Jon S. Odorico, Carlo Socci, Rossana Caldara, Julien Branchereau, Angelika C. Gruessner, Antonio Secchi, Flavia Neri, Takashi Kenmochi, Boggi, Ugo, Vistoli, Fabio, Andres, Axel, Arbogast, Helmut, Badet, Lionel, Baronti, Walter, Bartlett, Stephen T, Benedetti, Enrico, Branchereau, Julien, W Rd Burke, George, Buron, Fanny, Caldara, Rossana, Cardillo, Massimo, Casanova, Daniel, Cipriani, Federica, Cooper, Matthew, Cupisti, Adamasco, Davide, Josè, Drachenberg, Cinthia, de Koning, Eelco Jp, Ettorre, Giuseppe Maria, Fernandez Cruz, Laureano, Fridell, Jonathan, Friend, Peter J, Furian, Lucrezia, Gaber, Osama, Gruessner, Angelika C, Gruessner, Rainer W, Gunton, Jenny, Han, Duck Jong, Iacopi, Sara, Kauffmann, Emanuele Federico, Kaufman, Dixon, Kenmochi, Takashi, Khambalia, Hussein A, Lai, Quirino, Langer, Robert M, Maffi, Paola, Marselli, Lorella, Menichetti, Francesco, Miccoli, Mario, Mittal, Shruti, Morelon, Emmanuel, Napoli, Niccolò, Neri, Flavia, Oberholzer, Jose, Odorico, Jon, Öllinger, Robert, Oniscu, Gabriel, Orlando, Giuseppe, Ortenzi, Monica, Perosa, Marcelo, Perrone, Vittorio Grazio, Pleass, Henry, Redfield, Robert R, Ricci, Claudio, Rigotti, Paolo, Robertson, Paul R, Ross, Lainie, Rossi, Massimo, Saudek, Frantisek, Scalea, Joseph, Schenker, Peter, Secchi, Antonio, Socci, Carlo, Sousa Silva, Donzilia, Squifflet, Jean Paul, Stock, Peter, Stratta, Robert, Terrenzio, Chiara, Uva, Pablo, Watson, Christopher, White, Steven A, Marchetti, Piero, Kandaswamy, Raja, Berney, Thierry, Boggi, Ugo [0000-0002-7505-5896], Vistoli, Fabio [0000-0003-2115-4191], Andres, Axel [0000-0003-3329-0801], Arbogast, Helmut P [0000-0001-5410-8699], Badet, Lionel [0000-0002-9596-0279], Baronti, Walter [0000-0002-4532-3028], Bartlett, Stephen T [0000-0002-3980-2559], Benedetti, Enrico [0000-0003-1120-6058], Branchereau, Julien [0000-0002-8460-9352], Burke, George W [0000-0002-6888-2842], Buron, Fanny [0000-0003-0404-6746], Caldara, Rossana [0000-0001-7115-5681], Cardillo, Massimo [0000-0002-2776-2297], Casanova, Daniel [0000-0003-3863-5039], Cipriani, Federica [0000-0002-8651-5982], Cooper, Matthew [0000-0002-3438-9638], Cupisti, Adamasco [0000-0002-8995-936X], Davide, Josè [0000-0003-3174-2456], Drachenberg, Cinthia [0000-0002-3104-5661], de Koning, Eelco JP [0000-0002-1232-7022], Ettorre, Giuseppe Maria [0000-0002-7501-5472], Fernandez Cruz, Laureano [0000-0001-5652-1209], Fridell, Jonathan A [0000-0002-8708-1506], Friend, Peter J [0000-0003-0841-9685], Furian, Lucrezia [0000-0002-2264-7986], Gaber, Osama A [0000-0002-9444-3202], Gruessner, Angelika C [0000-0001-5961-5913], Gruessner, Rainer WG [0000-0002-2094-9817], Gunton, Jenny E [0000-0002-8127-9773], Han, Duck-Jong [0000-0002-0990-6824], Kauffmann, Emanuele Federico [0000-0001-7634-4844], Kaufman, Dixon [0000-0003-3615-0994], Kenmochi, Takashi [0000-0002-9090-8770], Khambalia, Hussein A [0000-0002-7553-3026], Lai, Quirino [0000-0003-1487-3235], Langer, Robert M [0000-0001-8349-1260], Maffi, Paola [0000-0001-5011-6499], Marselli, Lorella [0000-0002-6698-2962], Menichetti, Francesco [0000-0003-0824-7166], Miccoli, Mario [0000-0002-8632-6145], Mittal, Shruti [0000-0003-2390-5366], Morelon, Emmanuel [0000-0001-9928-1671], Napoli, Niccolò [0000-0003-2538-9158], Neri, Flavia [0000-0002-2677-8967], Oberholzer, Jose [0000-0002-1069-2501], Odorico, Jon S [0000-0003-1096-464X], Öllinger, Robert [0000-0002-4499-1673], Oniscu, Gabriel [0000-0003-1714-920X], Orlando, Giuseppe [0000-0002-6460-7974], Ortenzi, Monica [0000-0002-6508-6488], Perosa, Marcelo [0000-0002-8576-9761], Pleass, Henry [0000-0002-9814-0452], Redfield, Robert R [0000-0001-5986-3466], Ricci, Claudio [0000-0002-6638-4479], Rigotti, Paolo [0000-0002-8895-935X], Ross, Lainie F [0000-0002-7395-3000], Rossi, Massimo [0000-0001-5105-4656], Saudek, Frantisek [0000-0002-0448-4351], Scalea, Joseph R [0000-0001-8278-2859], Schenker, Peter [0000-0002-3607-6993], Secchi, Antonio [0000-0002-4208-5116], Socci, Carlo [0000-0002-3276-5556], Sousa Silva, Donzilia [0000-0002-7165-3581], Squifflet, Jean Paul [0000-0002-0467-7559], Stock, Peter G [0000-0002-5806-0167], Stratta, Robert J [0000-0001-7634-094X], Terrenzio, Chiara [0000-0002-0629-2134], Uva, Pablo [0000-0001-7317-3875], Watson, Christopher JE [0000-0002-0590-4901], Marchetti, Piero [0000-0003-4907-0635], Kandaswamy, Raja [0000-0003-4302-0119], Berney, Thierry [0000-0002-4230-9378], Apollo - University of Cambridge Repository, Boggi U., Vistoli F., Andres A., Arbogast H.P., Badet L., Baronti W., Bartlett S.T., Benedetti E., Branchereau J., Burke G.W., Buron F., Caldara R., Cardillo M., Casanova D., Cipriani F., Cooper M., Cupisti A., Davide J., Drachenberg C., de Koning E.J.P., Ettorre G.M., Fernandez Cruz L., Fridell J.A., Friend P.J., Furian L., Gaber O.A., Gruessner A.C., Gruessner R.W.G., Gunton J.E., Han D.-J., Iacopi S., Kauffmann E.F., Kaufman D., Kenmochi T., Khambalia H.A., Lai Q., Langer R.M., Maffi P., Marselli L., Menichetti F., Miccoli M., Mittal S., Morelon E., Napoli N., Neri F., Oberholzer J., Odorico J.S., Ollinger R., Oniscu G., Orlando G., Ortenzi M., Perosa M., Perrone V.G., Pleass H., Redfield R.R., Ricci C., Rigotti P., Paul Robertson R., Ross L.F., Rossi M., Saudek F., Scalea J.R., Schenker P., Secchi A., Socci C., Sousa Silva D., Squifflet J.P., Stock P.G., Stratta R.J., Terrenzio C., Uva P., Watson C.J.E., White S.A., Marchetti P., Kandaswamy R., and Berney T.

Subjects
medicine.medical_specialty, medicine.medical_treatment, Pancreas transplantation, clinical research/practice, Pancreas/simultaneous pancreas-kidney transplantation, Quality of life, Renal Dialysi, Renal Dialysis, Diabetes mellitus, medicine, Risk of mortality, Humans, Immunology and Allergy, survey, Pharmacology (medical), Survey, Intensive care medicine, Dialysis, Kidney transplantation, pancreas/simultaneous pancreas‐kidney transplantation, Transplantation, ddc:617, diabetes, pancreas/simultaneous pancreas-kidney transplantation, business.industry, Diabetes, Graft Survival, medicine.disease, Kidney Transplantation, Diabetes Mellitus, Type 1, surgical procedures, operative, diabete, Clinical research/practice, Quality of Life, Life expectancy, Special Articles, Original Article, Pancreas Transplantation, business, Human
Abstract

Funder: Fondazione Pisa, Pisa, Italy; Id: http://dx.doi.org/10.13039/100007368, Funder: Tuscany Region, Italy; Id: http://dx.doi.org/10.13039/501100009888, Funder: Pisa University Hospital, Pisa, Italy, Funder: University of Pisa, Pisa, Italy; Id: http://dx.doi.org/10.13039/501100007514, The First World Consensus Conference on Pancreas Transplantation provided 49 jury deliberations regarding the impact of pancreas transplantation on the treatment of diabetic patients, and 110 experts' recommendations for the practice of pancreas transplantation. The main message from this consensus conference is that both simultaneous pancreas-kidney transplantation (SPK) and pancreas transplantation alone can improve long-term patient survival, and all types of pancreas transplantation dramatically improve the quality of life of recipients. Pancreas transplantation may also improve the course of chronic complications of diabetes, depending on their severity. Therefore, the advantages of pancreas transplantation appear to clearly surpass potential disadvantages. Pancreas after kidney transplantation increases the risk of mortality only in the early period after transplantation, but is associated with improved life expectancy thereafter. Additionally, preemptive SPK, when compared to SPK performed in patients undergoing dialysis, appears to be associated with improved outcomes. Time on dialysis has negative prognostic implications in SPK recipients. Increased long-term survival, improvement in the course of diabetic complications, and amelioration of quality of life justify preferential allocation of kidney grafts to SPK recipients. Audience discussions and live voting are available online at the following URL address: http://mediaeventi.unipi.it/category/1st-world-consensus-conference-of-pancreas-transplantation/246.

Published
2021

11. Associations between pancreatic expression quantitative traits and risk of pancreatic ductal adenocarcinoma.

Author

Pistoni L, Gentiluomo M, Lu Y, López de Maturana E, Hlavac V, Vanella G, Darvasi E, Milanetto AC, Oliverius M, Vashist Y, Di Leo M, Mohelnikova-Duchonova B, Talar-Wojnarowska R, Gheorghe C, Petrone MC, Strobel O, Arcidiacono PG, Vodickova L, Szentesi A, Capurso G, Gajdán L, Malleo G, Theodoropoulos GE, Basso D, Soucek P, Brenner H, Lawlor RT, Morelli L, Ivanauskas A, Kauffmann EF, Macauda A, Gazouli M, Archibugi L, Nentwich M, Loveček M, Cavestro GM, Vodicka P, Landi S, Tavano F, Sperti C, Hackert T, Kupcinskas J, Pezzilli R, Andriulli A, Pollina L, Kreivenaite E, Gioffreda D, Jamroziak K, Hegyi P, Izbicki JR, Testoni SGG, Zuppardo RA, Bozzato D, Neoptolemos JP, Malats N, Canzian F, and Campa D

Subjects
Aged, Alleles, Case-Control Studies, Female, GTPase-Activating Proteins genetics, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Carcinoma, Pancreatic Ductal genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Pancreatic Neoplasms genetics, Quantitative Trait Loci
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Its poor prognosis is predominantly due to the fact that most patients remain asymptomatic until the disease reaches an advanced stage, alongside the lack of early markers and screening strategies. A better understanding of PDAC risk factors is essential for the identification of groups at high risk in the population. Genome-wide association studies (GWAS) have been a powerful tool for detecting genetic variants associated with complex traits, including pancreatic cancer. By exploiting functional and GWAS data, we investigated the associations between polymorphisms affecting gene function in the pancreas (expression quantitative trait loci, eQTLs) and PDAC risk. In a two-phase approach, we analysed 13 713 PDAC cases and 43 784 controls and identified a genome-wide significant association between the A allele of the rs2035875 polymorphism and increased PDAC risk (P = 7.14 × 10-10). This allele is known to be associated with increased expression in the pancreas of the keratin genes KRT8 and KRT18, whose increased levels have been reported to correlate with various tumour cell characteristics. Additionally, the A allele of the rs789744 variant was associated with decreased risk of developing PDAC (P = 3.56 × 10-6). This single nucleotide polymorphism is situated in the SRGAP1 gene and the A allele is associated with higher expression of the gene, which in turn inactivates the cyclin-dependent protein 42 (CDC42) gene expression, thus decreasing the risk of PDAC. In conclusion, we present here a functional-based novel PDAC risk locus and an additional strong candidate supported by significant associations and plausible biological mechanisms., (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Published
2021
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12. The role of laparoscopy in adult bowel obstruction caused by intussusception.

Author

Tartaglia D, Bertolucci A, Palmeri M, Kauffmann EF, Napoli N, Galatioto C, Lippolis PV, Zocco G, and Seccia M

Subjects
Adolescent, Adult, Colon, Female, Humans, Ileal Diseases complications, Ileal Diseases surgery, Intestinal Obstruction diagnosis, Intestinal Obstruction etiology, Intestinal Obstruction surgery, Intussusception complications, Male, Middle Aged, Retrospective Studies, Young Adult, Ileal Diseases diagnosis, Intussusception diagnosis, Intussusception surgery, Laparoscopy
Abstract

Aim: The intestinal intussusception in the adult represent 1% of all occlusions. Organic causes are detectable in 90% of cases. Aim of this study is to discuss the diagnostic and therapeutic iter of adult intestinal intussusception with particular emphasis on role of laparoscopy., Materials and Methods: We retrospectively considered 10 cases of intussusception between January 2000 and January 2013, demographic and clinical issue, location of invagination, the type of surgical treatment, the post-operative morbidity and mortality and histological nature of occlusion cause., Results: Ten (F: M 1.5:1) patients were admitted in emergency with bowel obstruction, the median age was 50 years (r.18-91). All required surgical treatment. Three patients (30%) underwent a totally laparoscopic procedure, four patients (40%) laparoscopic exploration followed by laparotomy, three patients (30%) open surgery directly. The invagination was ileo-ileal (50%), ileo-colonic (40%) and colo-colonic (10%). Nine out of ten underwent to surgical resection. The malignancy was the most frequent cause., Discussion: In case of colonic intussusception should not be performed any reduction because the frequent association with neoplastic disease. The laparoscopy can be safe and effective to allow, in entero-enteric and entero-colic intussusception, the definitive treatment of the occlusion. In the case of colo-colonic intussusception laparoscopy is a valuable diagnostic aid and can facilitate the later processing., Conclusion: The intestinal invaginations diagnosis can often be difficult. Laparoscopy is safe and effective in the diagnosis and treatment of adult intussusception.

Published
2014

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