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4. Enhanced isolation of SARS-CoV-2 by TMPRSS2- expressing cells

Author

Matsuyama, Shutoku, Nao, Naganori, Shirato, Kazuya, Kawase, Miyuki, Saito, Shinji, Takayama, Ikuyo, Nagata, Noriyo, Sekizuka, Tsuyoshi, Katoh, Hiroshi, Kato, Fumihiro, Sakata, Masafumi, Tahara, Maino, Kutsuna, Satoshi, Ohmagari, Norio, Kuroda, Makoto, Suzuki, Tadaki, Kageyama, Tsutomu, and Takeda, Makoto

Published
2020

5. Sofosbuvir Suppresses the Genome Replication of DENV1 in Human Hepatic Huh7 Cells

Author

Kurosawa, Madoka, primary, Kato, Fumihiro, additional, Hishiki, Takayuki, additional, Ito, Saori, additional, Fujisawa, Hiroki, additional, Yamaguchi, Tatsuo, additional, Moriguchi, Misato, additional, Hosokawa, Kohei, additional, Watanabe, Tadashi, additional, Saito-Tarashima, Noriko, additional, Minakawa, Noriaki, additional, and Fujimuro, Masahiro, additional

Published
2024
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9. Nationwide and long-term molecular epidemiologic studies of mumps viruses that circulated in Japan between 1986 and 2017

Author

Kidokoro, Minoru, Shiino, Teiichiro, Yamaguchi, Tomohiro, Nariai, Eri, Kodama, Hiroe, Nakata, Keiko, Sano, Takako, Gotou, Keiko, Kisu, Tomoko, Maruyama, Tomomi, Kuba, Yumani, Sakata, Wakako, Higashi, Teruaki, Kiyota, Naoko, Sakai, Takashi, Yahiro, Shunsuke, Nagita, Akira, Watanabe, Kaori, Hirokawa, Chika, Hamabata, Hirotsune, Fujii, Yoshiki, Yamamoto, Miwako, Yokoi, Hajime, Sakamoto, Misako, Saito, Hiroyuki, Shibata, Chihiro, Inada, Machi, Fujitani, Misako, Minagawa, Hiroko, Ito, Miyabi, Shima, Akari, Murano, Keiko, Katoh, Hiroshi, Kato, Fumihiro, Takeda, Makoto, and Suga, Shigeru

Subjects
Microbiology (medical), Microbiology
Abstract

In Japan, major mumps outbreaks still occur every 4–5 years because of low mumps vaccine coverage (30–40%) owing to the voluntary immunization program. Herein, to prepare for a regular immunization program, we aimed to reveal the nationwide and long-term molecular epidemiological trends of the mumps virus (MuV) in Japan. Additionally, we performed whole-genome sequencing (WGS) using next-generation sequencing to assess results from conventional genotyping using MuV sequences of the small-hydrophobic (SH) gene. We analyzed 1,064 SH gene sequences from mumps clinical samples and MuV isolates collected from 25 prefectures from 1986 to 2017. The results showed that six genotypes, namely B (110), F (1), G (900), H (3), J (41), and L (9) were identified, and the dominant genotypes changed every decade in Japan since the 1980s. Genotype G has been exclusively circulating since the early 2000s. Seven clades were identified for genotype G using SH sequence-based classification. To verify the results, we performed WGS on 77 representative isolates of genotype G using NGS and phylogenetically analyzed them. Five clades were identified with high bootstrap values and designated as Japanese clade (JPC)-1, -2, -3, -4, -5. JPC-1 and -3 accounted for over 80% of the total genotype G isolates (68.3 and 13.8%, respectively). Of these, JPC-2 and -5, were newly identified clades in Japan through this study. This is the first report describing the nationwide and long-term molecular epidemiology of MuV in Japan. The results provide information about Japanese domestic genotypes, which is essential for evaluating the mumps elimination progress in Japan after the forthcoming introduction of the mumps vaccine into Japan’s regular immunization program. Furthermore, the study shows that WGS analysis using NGS is more accurate than results obtained from conventional SH sequence-based classification and is a powerful tool for accurate molecular epidemiology studies.

Published
2022
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12. Dengue Virus Type 2 in Travelers Returning to Japan from Sri Lanka, 2017

Author

Tsuboi, Motoyuki, Kutsuna, Satoshi, Maeki, Takahiro, Taniguchi, Satoshi, Tajima, Shigeru, Kato, Fumihiro, Lim, Chang -Kweng, Saijo, Masayuki, Takaya, Saho, Katanami, Yuichi, Kato, Yasuyuki, and Ohmagari, Norio

Subjects
Travelers -- Health aspects, Dengue virus -- Health aspects, Health
Abstract

In 2009, Sri Lanka experienced an outbreak of dengue fever, which was the largest since dengue fever was classified as a reportable disease in 1996. During that outbreak, 35,008 dengue [...]

Published
2017
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13. Dengue Virus Exported from Cote d'Ivoire to Japan, June 2017

Author

Suzuki, Tetsuya, Kutsuna, Satoshi, Taniguchi, Satoshi, Tajima, Shigeru, Maeki, Takahiro, Kato, Fumihiro, Lim, Chang-Kweng, Saijo, Masayuki, Tsuboi, Motoyuki, Yamamoto, Kei, Morioka, Shinichiro, Ishikane, Masahiro, Hayakawa, Kayoko, Kato, Yasuyuki, and Ohmagari, Norio

Subjects
Disease transmission -- Diagnosis -- Health aspects, Infection -- Diagnosis -- Health aspects, Phylogeny -- Health aspects, Dengue virus -- Health aspects, Cladistic analysis -- Health aspects, Health
Abstract

In recent decades, dengue virus (DENV) infection has been spreading worldwide. Although in Africa the leading cause of acute febrile illness is still malaria, dengue has recently gained momentum (1). [...]

Published
2017
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14. Antiviral Activity of CD437 Against Mumps Virus

Author

Kato, Fumihiro, primary, Nakatsu, Yuichiro, additional, Murano, Keiko, additional, Wakata, Aika, additional, Kubota, Toru, additional, Hishiki, Takayuki, additional, Yamaji, Toshiyuki, additional, Kidokoro, Minoru, additional, Katoh, Hiroshi, additional, and Takeda, Makoto, additional

Published
2021
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16. Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR-/- mice maps to prM residues conserved amongst African genotype viruses

Author

Nakayama, Eri, primary, Kato, Fumihiro, additional, Tajima, Shigeru, additional, Ogawa, Shinya, additional, Yan, Kexin, additional, Takahashi, Kenta, additional, Sato, Yuko, additional, Suzuki, Tadaki, additional, Kawai, Yasuhiro, additional, Inagaki, Takuya, additional, Taniguchi, Satoshi, additional, Le, Thuy T., additional, Tang, Bing, additional, Prow, Natalie A., additional, Uda, Akihiko, additional, Maeki, Takahiro, additional, Lim, Chang-Kweng, additional, Khromykh, Alexander A., additional, Suhrbier, Andreas, additional, and Saijo, Masayuki, additional

Published
2021
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19. Sphingomyelin Is Essential for the Structure and Function of the Double-Membrane Vesicles in Hepatitis C Virus RNA Replication Factories

Author

Gewaid, Hossam, primary, Aoyagi, Haruyo, additional, Arita, Minetaro, additional, Watashi, Koichi, additional, Suzuki, Ryosuke, additional, Sakai, Shota, additional, Kumagai, Keigo, additional, Yamaji, Toshiyuki, additional, Fukasawa, Masayoshi, additional, Kato, Fumihiro, additional, Hishiki, Takayuki, additional, Mimata, Ayako, additional, Sakamaki, Yuriko, additional, Ichinose, Shizuko, additional, Hanada, Kentaro, additional, Muramatsu, Masamichi, additional, Wakita, Takaji, additional, and Aizaki, Hideki, additional

Published
2020
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21. Analysis of the Function of the Lymphocytic Choriomeningitis Virus S Segment Untranslated Region on Growth Capacity In Vitro and on Virulence In Vivo

Author

Taniguchi, Satoshi, primary, Yoshikawa, Tomoki, additional, Shimojima, Masayuki, additional, Fukushi, Shuetsu, additional, Kurosu, Takeshi, additional, Tani, Hideki, additional, Fukuma, Aiko, additional, Kato, Fumihiro, additional, Nakayama, Eri, additional, Maeki, Takahiro, additional, Tajima, Shigeru, additional, Lim, Chang-Kweng, additional, Ebihara, Hideki, additional, Kyuwa, Shigeru, additional, Morikawa, Shigeru, additional, and Saijo, Masayuki, additional

Published
2020
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22. Development of Genetic Diagnostic Methods for Detection for Novel Coronavirus 2019(nCoV-2019) in Japan

Author

Shirato, Kazuya, primary, Nao, Naganori, additional, Katano, Harutaka, additional, Takayama, Ikuyo, additional, Saito, Shinji, additional, Kato, Fumihiro, additional, Katoh, Hiroshi, additional, Sakata, Masafumi, additional, Nakatsu, Yuichiro, additional, Mori, Yoshio, additional, Kageyama, Tsutomu, additional, Matsuyama, Shutoku, additional, and Takeda, Makoto, additional

Published
2020
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23. Bitter melon fruit extract enhances intracellular ATP production and insulin secretion from rat pancreatic β -cells.

Author

Shimada, Takumi, Kato, Fumihiro, Dwijayanti, Dinia Rizqi, Nagata, Takuma, Kinoshita, Akito, Okuyama, Tetsuya, Nishizawa, Mikio, and Mukai, Eri

Subjects
ADENOSINE triphosphate, PANCREAS, BIOLOGICAL models, GLUCOSE intolerance, B cells, ANIMAL experimentation, MELONS, METABOLISM, DIABETES, AMINOGLYCOSIDES, BLOOD sugar, HYPOGLYCEMIC agents, RATS, PLANT extracts, INSULIN resistance
Abstract

Bitter melon (Momordica charantia L.) has been shown to have various health-promoting activities, including antidiabetic and hypoglycaemic effects. Improvement in insulin sensitivity and increase in glucose utilisation in peripheral tissues have been reported, but the effect on insulin secretion from pancreatic β-cells remains unclear. In this study, we investigated the effect of bitter melon fruit on insulin secretion from β-cells and the underlying mechanism. The green fruit of bitter melon was freeze-dried and extracted with methanol. The bitter melon fruit extract (BMFE) was fractionated using ethyl acetate (fraction A), n-butanol (fraction B) and water (fraction C). Insulin secretory capacity from INS-1 rat insulinoma cell line and rat pancreatic islets, as well as glucose tolerance in rats by oral glucose tolerance test (OGTT), was measured using BMFE and fractions. ATP production in β-cells was also examined. BMFE augmented insulin secretion from INS-1 cells in a dose-dependent manner. The significant augmentation of insulin secretion was independent of the glucose dose. Fraction A (i.e. hydrophobic fraction), but not fractions B and C, augmented insulin secretion significantly at the same level as that by BMFE. This finding was also observed in pancreatic islets. In OGTT, BMFE and fraction A decreased blood glucose levels and increased serum insulin levels after glucose loading. The decrease in blood glucose levels was also observed in streptozotocin-induced diabetic rats. In addition, BMFE and fraction A increased the ATP content in β-cells. We concluded that hydrophobic components of BMFE increase ATP production and augment insulin secretion from β-cells, consequently decreasing blood glucose levels. [ABSTRACT FROM AUTHOR]

Published
2022
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24. ウィキデータとGLAM

Author

Kato, Fumihiro

Abstract

2019-11-13 にOpenGLAM JAPAN 図書館総合展2019 ブース&フォーラムで発表した内容https://openglam.github.io/LF2019.html

Published
2019
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26. CiNii Research

Author

Kato, Fumihiro

Abstract

2019-05-30 国立情報学研究所 学術情報基盤オープンフォーラム2019 コンテンツ・OSトラック2: 図書館の強みを活かす次期JAIRO CloudとCiNii Research

Published
2019
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27. Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR-/- mice maps to prM residues conserved amongst African genotype viruses.

Author

Nakayama, Eri, Kato, Fumihiro, Tajima, Shigeru, Ogawa, Shinya, Yan, Kexin, Takahashi, Kenta, Sato, Yuko, Suzuki, Tadaki, Kawai, Yasuhiro, Inagaki, Takuya, Taniguchi, Satoshi, Le, Thuy T., Tang, Bing, Prow, Natalie A., Uda, Akihiko, Maeki, Takahiro, Lim, Chang-Kweng, Khromykh, Alexander A., Suhrbier, Andreas, and Saijo, Masayuki

Subjects
*ZIKA virus, *ADULTS, *AMINO acid residues, *MICE, *GENOTYPES, *AFRICAN swine fever
Abstract

Zika virus (ZIKV) strains are classified into the African and Asian genotypes. The higher virulence of the African MR766 strain, which has been used extensively in ZIKV research, in adult IFNα/β receptor knockout (IFNAR-/-) mice is widely viewed as an artifact associated with mouse adaptation due to at least 146 passages in wild-type suckling mouse brains. To gain insights into the molecular determinants of MR766's virulence, a series of genes from MR766 were swapped with those from the Asian genotype PRVABC59 isolate, which is less virulent in IFNAR-/- mice. MR766 causes 100% lethal infection in IFNAR-/- mice, but when the prM gene of MR766 was replaced with that of PRVABC59, the chimera MR/PR(prM) showed 0% lethal infection. The reduced virulence was associated with reduced neuroinvasiveness, with MR766 brain titers ≈3 logs higher than those of MR/PR(prM) after subcutaneous infection, but was not significantly different in brain titers of MR766 and MR/PR(prM) after intracranial inoculation. MR/PR(prM) also showed reduced transcytosis when compared with MR766 in vitro. The high neuroinvasiveness of MR766 in IFNAR-/- mice could be linked to the 10 amino acids that differ between the prM proteins of MR766 and PRVABC59, with 5 of these changes affecting positive charge and hydrophobicity on the exposed surface of the prM protein. These 10 amino acids are highly conserved amongst African ZIKV isolates, irrespective of suckling mouse passage, arguing that the high virulence of MR766 in adult IFNAR-/- mice is not the result of mouse adaptation. Author summary: Contemporary Asian genotype Zika virus (ZIKV) caused a large epidemic in the Americas and was associated with congenital abnormalities and neurological disease in adults, whereas African ZIKV has not been reported to cause neurological malformations in humans. Whether the lack of reported cases caused by African ZIKV simply reflects under-reporting remains unclear. Numerous studies have attempted to explain how and why these severe manifestations are restricted to ZIKV of Asian origin. Although several studies have reported that African ZIKV strains are more virulent in adult IFNα/β receptor knockout (IFNAR-/-) mice, the representative African ZIKV strain MR766 is believed to have artefactually high virulence in adult IFNAR-/- mice due to its extensive passage history in suckling wild-type mouse brains. However, we provide evidence herein that the lethality of MR766 in the adult IFNAR-/- mice is associated with 10 amino acid residues in the prM protein that are associated with an increased ability to cross the blood-brain barrier. These amino acids are highly conserved in African genotype viruses, irrespective of multiple passage history in suckling mouse brains, suggesting that high virulence is a legitimate characteristic of African ZIKVs. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Wikidataの紹介

Author

Kato, Fumihiro

Abstract

2018-10-31 図書館総合展2018 ウィキペディア・OpenStreetMap編集の実際

Published
2018
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36. SPARQLライブラリの紹介

Author

Kato, Fumihiro

Abstract

2017-08-03 COREDO日本橋の理研で開催された理研シンポジウム 第1回Linked Open Data (LOD) 活用ワークショップで発表した内容

Published
2018
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39. LODの基礎知識

Author

Kato, Fumihiro

Abstract

2016-10-07 に科学技術振興機構 で行われた第1回RDF講習会での発表資料

Published
2018
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45. BioHackathon series in 2013 and 2014: improvements of semantic interoperability in life science data and services

Author

Katayama, Toshiaki, primary, Kawashima, Shuichi, additional, Micklem, Gos, additional, Kawano, Shin, additional, Kim, Jin-Dong, additional, Kocbek, Simon, additional, Okamoto, Shinobu, additional, Wang, Yue, additional, Wu, Hongyan, additional, Yamaguchi, Atsuko, additional, Yamamoto, Yasunori, additional, Antezana, Erick, additional, Aoki-Kinoshita, Kiyoko F., additional, Arakawa, Kazuharu, additional, Banno, Masaki, additional, Baran, Joachim, additional, Bolleman, Jerven T., additional, Bonnal, Raoul J. P., additional, Bono, Hidemasa, additional, Fernández-Breis, Jesualdo T., additional, Buels, Robert, additional, Campbell, Matthew P., additional, Chiba, Hirokazu, additional, Cock, Peter J. A., additional, Cohen, Kevin B., additional, Dumontier, Michel, additional, Fujisawa, Takatomo, additional, Fujiwara, Toyofumi, additional, Garcia, Leyla, additional, Gaudet, Pascale, additional, Hattori, Emi, additional, Hoehndorf, Robert, additional, Itaya, Kotone, additional, Ito, Maori, additional, Jamieson, Daniel, additional, Jupp, Simon, additional, Juty, Nick, additional, Kalderimis, Alex, additional, Kato, Fumihiro, additional, Kawaji, Hideya, additional, Kawashima, Takeshi, additional, Kinjo, Akira R., additional, Komiyama, Yusuke, additional, Kotera, Masaaki, additional, Kushida, Tatsuya, additional, Malone, James, additional, Matsubara, Masaaki, additional, Mizuno, Satoshi, additional, Mizutani, Sayaka, additional, Mori, Hiroshi, additional, Moriya, Yuki, additional, Murakami, Katsuhiko, additional, Nakazato, Takeru, additional, Nishide, Hiroyo, additional, Nishimura, Yosuke, additional, Ogishima, Soichi, additional, Ohta, Tazro, additional, Okuda, Shujiro, additional, Ono, Hiromasa, additional, Perez-Riverol, Yasset, additional, Shinmachi, Daisuke, additional, Splendiani, Andrea, additional, Strozzi, Francesco, additional, Suzuki, Shinya, additional, Takehara, Junichi, additional, Thompson, Mark, additional, Tokimatsu, Toshiaki, additional, Uchiyama, Ikuo, additional, Verspoor, Karin, additional, Wilkinson, Mark D., additional, Wimalaratne, Sarala, additional, Yamada, Issaku, additional, Yamamoto, Nozomi, additional, Yarimizu, Masayuki, additional, Kawamoto, Shoko, additional, and Takagi, Toshihisa, additional

Published
2019
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46. Increased growth ability and pathogenicity of American- and Pacific-subtype Zika virus (ZIKV) strains compared with a Southeast Asian-subtype ZIKV strain

Author

Kawai, Yasuhiro, primary, Nakayama, Eri, additional, Takahashi, Kenta, additional, Taniguchi, Satoshi, additional, Shibasaki, Ken-ichi, additional, Kato, Fumihiro, additional, Maeki, Takahiro, additional, Suzuki, Tadaki, additional, Tajima, Shigeru, additional, Saijo, Masayuki, additional, and Lim, Chang-Kweng, additional

Published
2019
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47. The R2TP complex regulates paramyxovirus RNA synthesis

Author

Katoh, Hiroshi, primary, Sekizuka, Tsuyoshi, additional, Nakatsu, Yuichiro, additional, Nakagawa, Reiko, additional, Nao, Naganori, additional, Sakata, Masafumi, additional, Kato, Fumihiro, additional, Kuroda, Makoto, additional, Kidokoro, Minoru, additional, and Takeda, Makoto, additional

Published
2019
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48. Neutralization Potency of Sera from Vietnamese Patients with Japanese Encephalitis (JE) against Genotypes I and V JE Viruses

Author

Nguyen, Thi Thu Thuy, primary, Tajima, Shigeru, additional, Ikeda, Makiko, additional, Nguyen, Thu Trang, additional, Le, Thu Thi Hien, additional, Pham, Hang Thi Thu, additional, Pham, Do Quyen, additional, Le, Mai Thi Quynh, additional, Maeki, Takahiro, additional, Taniguchi, Satoshi, additional, Kato, Fumihiro, additional, Moi, Meng Ling, additional, Morita, Koichi, additional, Lim, Chang-Kweng, additional, Saijo, Masayuki, additional, and Hasebe, Futoshi, additional

Published
2019
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49. Dengue Virus Type 2 Infection in a Traveler Returning from Saudi Arabia to Japan

Author

Matsui, Toshihiro, primary, Kinoshita, Noriko, additional, Maeki, Takahiro, additional, Kutsuna, Satoshi, additional, Nakamura, Keiji, additional, Nakamoto, Takahito, additional, Ishikane, Masahiro, additional, Tajima, Shigeru, additional, Kato, Fumihiro, additional, Taniguchi, Satoshi, additional, Lim, Chang-Kweng, additional, Saijo, Masayuki, additional, and Ohmagari, Norio, additional

Published
2019
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50. Evaluation of Macaca radiata as a non-human primate model of Dengue virus infection

Author

40202337, Kato, Fumihiro, Ishida, Yuki, Kawakami, Akihiko, Takasaki, Tomohiko, Saijo, Masayuki, Miura, Tomoyuki, Hishiki, Takayuki, 40202337, Kato, Fumihiro, Ishida, Yuki, Kawakami, Akihiko, Takasaki, Tomohiko, Saijo, Masayuki, Miura, Tomoyuki, and Hishiki, Takayuki

Abstract

Dengue virus (DENV) causes a wide range of illnesses in humans, including dengue fever and dengue haemorrhagic fever. Current animal models of DENV infection are limited for understanding infectious diseases in humans. Bonnet monkeys (Macaca radiata), a type of Old World monkey, have been used to study experimental and natural infections by flaviviruses, but Old World monkeys have not yet been used as DENV infection models. In this study, the replication levels of several DENV strains were evaluated using peripheral blood mononuclear cells. Our findings indicated that DENV-4 09-48 strain, isolated from a traveller returning from India in 2009, was a highly replicative virus. Three bonnet monkeys were infected with 09-48 strain and antibody responses were assessed. DENV nonstructural protein 1 antigen was detected and high viraemia was observed. These results indicated that bonnet monkeys and 09-48 strain could be used as a reliable primate model for the study of DENV.

Published
2018

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