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2. Functional role of vitronectin in breast cancer

Author

Bera, Alakesh, primary, Subramanian, Madhan, additional, Karaian, John, additional, Eklund, Michael, additional, Radhakrishnan, Surya, additional, Gana, Nahbuma, additional, Rothwell, Stephen, additional, Pollard, Harvey, additional, Hu, Hai, additional, Shriver, Craig D., additional, and Srivastava, Meera, additional

Published
2020
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9. Effects of volume and composition of the resuscitative fluids in the treatment of hemorrhagic shock.

Author

Sharma, Pushpa, Benford, Brandi, Karaian, John E., and Keneally, Ryan

Subjects
HEMORRHAGIC shock, RESUSCITATION, LABORATORY rats, FIRST aid in illness & injury, CARDIAC resuscitation
Abstract

Objectives: To evaluate the effectiveness of normal saline, hypertonic saline, and Ringer's lactate solution followed by blood infusion in ameliorating the physiological, biochemical, and organ functions following hemorrhagic shock (HS) in rats. Materials and Methods: Anesthetized, male Sprague-Dawley rats underwent computer-controlled HS, and were randomly divided into five groups consisting of (1) sham, (2) HS without resuscitation, (3) resuscitation with normal saline, (4) resuscitation with hypertonic saline, and (5) resuscitation with Ringer's lactate solution. All resuscitated animals were infused with subsequent infusion of shed blood. Animals were continuously monitored for physiological, hemodynamic, biochemical parameters, and organ dysfunctions. Results: Non-resuscitated animals were unable to survive due to hypotension, poor oxygen metabolism, and lactic acidosis. Although these HS related parameters were corrected by all the fluids used in this study, additional blood infusion was more effective than fluid resuscitation alone. Also, hypertonic saline was more effective than Ringer's lactate solution, and normal saline was the least effective in preserving the liver and kidney functions and muscle damage. Conclusions: All crystalloid fluids were significantly more effective in reversing the HS outcome when used with blood infusion, but hypertonic salinewith blood was more effective in preventing the organ damage than Lactated Ringers solutions or normal saline in the treatment of HS. [ABSTRACT FROM AUTHOR]

Published
2012
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10. Pyruvate improves redox status and decreases in indicators of hepatic apoptosis during hemorrhagic shock in swine.

Author

Mongan, Paul D., Capacchione, John, West, Shanda, Karaian, John, Dubois, Dawn, Keneally, Ryan, and Sharma, Pushpa

Subjects
PYRUVATES, LIVER diseases, HEMORRHAGIC shock
Abstract

Examines the mechanism of pyruvate in preventing liver damage during hemorrhagic shock. Maintenance of redox state by pyruvate; Prevention of intracellular antioxidants by pyruvate; Decrease of hepatic cellular death.

Published
2002
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