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11. Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

Author

Wormser, David, Angelantonio, Emanuele Di, Kaptoge, Stephen, Wood, Angela M, Gao, Pei, Sun, Qi, Walldius, Göran, Selmer, Randi, Verschuren, WM Monique, Bueno-de-Mesquita, H Bas, Engström, Gunnar, Ridker, Paul M, Njølstad, Inger, Iso, Hiroyasu, Holme, Ingar, Giampaoli, Simona, Tunstall-Pedoe, Hugh, Gaziano, J Michael, Brunner, Eric, Kee, Frank, Tosetto, Alberto, Meisinger, Christa, Brenner, Hermann, Ducimetiere, Pierre, Whincup, Peter H, Tipping, Robert W, Ford, Ian, Cremer, Peter, Hofman, Albert, Wilhelmsen, Lars, Clarke, Robert, Boer, Ian H de, Jukema, J Wouter, Ibañez, Alejandro Marín, Lawlor, Debbie A, DʼAgostino, Ralph B, Rodriguez, Beatriz, Casiglia, Edoardo, Stehouwer, Coen DA, Simons, Leon A, Nietert, Paul J, Barrett-Connor, Elizabeth, Panagiotakos, Demosthenes B, Björkelund, Cecilia, Strandberg, Timo E, Wassertheil-Smoller, Sylvia, Blazer, Dan G, Meade, Tom W, Welin, Lennart, Svärdsudd, Kurt, Woodward, Mark, Nissinen, Aulikki, Kromhout, Daan, Jørgensen, Torben, Tilvis, Reijo S, Guralnik, Jack M, Rosengren, Annika, Taylor, James O, Kiechl, Stefan, Dagenais, Gilles R, Gerry, F, Fowkes, R, Wallace, Robert B, Khaw, Kay-Tee, Shaffer, Jonathan A, Visser, Marjolein, Kauhanen, Jussi, Salonen, Jukka T, Gallacher, John, Ben-Shlomo, Yoav, Kitamura, Akihiko, Sundström, Johan, Wennberg, Patrik, Kiyohara, Yutaka, Daimon, Makoto, de la Cámara, Agustin Gómez, Cooper, Jackie A, Onat, Altan, Devereux, Richard, Mukamal, Kenneth J, Dankner, Rachel, Knuiman, Matthew W, Crespo, Carlos J, Gansevoort, Ron T, Goldbourt, Uri, Nordestgaard, Børge G, Shaw, Jonathan E, Mussolino, Michael, Nakagawa, Hidaeki, Fletcher, Astrid, Kuller, Lewis H, Gillum, Richard F, Gudnason, Vilmundur, Assmann, Gerd, Wald, Nicholas, Jousilahti, Pekka R, Greenland, Philip, Trevisan, Maurizio, Ulmer, Hanno, Butterworth, Adam S, Folsom, Aaron R, Davey-Smith, George, Hu, Frank B, Danesh, John, Tipping, Robert W, Ford, Charles E, Simpson, Lara M, Walldius, Göran, Jungner, Ingmar, Folsom, Aaron R, Demerath, Ellen W, Franceschini, Nora, Lutsey, Pamela L, Panagiotakos, Demosthenes B, Pitsavos, Christos, Chrysohoou, Christina, Stefanadis, Christodoulos, Shaw, Jonathan E, Atkins, Robert, Zimmet, Paul Z, Barr, Elizabeth LM, Knuiman, Matthew W, Whincup, Peter H, Wannamethee, S Goya, Morris, Richard W, Willeit, Johann, Kiechl, Stefan, Weger, Siegfried, Oberhollenzer, Friedrich, Wald, Nicholas, Ebrahim, Shah, Lawlor, Debbie A, Gallacher, John, Ben-Shlomo, Yoav, Yarnell, John WG, Casiglia, Edoardo, Tikhonoff, Valérie, Greenland, Philip, Shay, Christina M, Garside, Daniel B, Nietert, Paul J, Sutherland, Susan E, Bachman, David L, Keil, Julian E, de Boer, Ian H, Kizer, Jorge R, Psaty, Bruce M, Mukamal, Kenneth J, Nordestgaard, Børge G, Tybjærg-Hansen, Anne, Jensen, Gorm B, Schnohr, Peter, Giampaoli, Simona, Palmieri, Luigi, Panico, Salvatore, Pilotto, Lorenza, Vanuzzo, Diego, de la Cámara, Agustin Gómez, Simons, Leon A, Simons, Judith, McCallum, John, Friedlander, Yechiel, Gerry, F, Fowkes, R, Price, Jackie F, Lee, Amanda J, Taylor, James O, Guralnik, Jack M, Phillips, Caroline L, Wallace, Robert B, Kohout, Frank J, Cornoni-Huntley, Joan C, Guralnik, Jack M, Blazer, Dan G, Guralnik, Jack M, Phillips, Caroline L, Phillips, Caroline L, Guralnik, Jack M, Khaw, Kay-Tee, Wareham, Nicholas J, Brenner, Hermann, Schöttker, Ben, Müller, Heiko, Rothenbacher, Dietrich, Wennberg, Patrik, Jansson, Jan-Håkan, Nissinen, Aulikki, Donfrancesco, Chiara, Giampaoli, Simona, Woodward, Mark, Vartiainen, Erkki, Jousilahti, Pekka R, Harald, Kennet, Salomaa, Veikko, DʼAgostino, Ralph B, Vasan, Ramachandran S, Fox, Caroline S, Pencina, Michael J, Daimon, Makoto, Oizumi, Toshihide, Kayama, Takamasa, Kato, Takeo, Bladbjerg, Else-Marie, Jørgensen, Torben, Møller, Lars, Jespersen, Jørgen, Dankner, Rachel, Chetrit, Angela, Lubin, Flora, Svärdsudd, Kurt, Eriksson, Henry, Welin, Lennart, Lappas, Georgios, Rosengren, Annika, Lappas, Georgios, Welin, Lennart, Svärdsudd, Kurt, Eriksson, Henry, Lappas, Georgios, Bengtsson, Calle, Lissner, Lauren, Björkelund, Cecilia, Cremer, Peter, Nagel, Dorothea, Strandberg, Timo E, Salomaa, Veikko, Tilvis, Reijo S, Miettinen, Tatu A, Tilvis, Reijo S, Strandberg, Timo E, Kiyohara, Yutaka, Arima, Hisatomi, Doi, Yasufumi, Ninomiya, Toshiharu, Rodriguez, Beatriz, Dekker, Jacqueline M, Nijpels, Giel, Stehouwer, Coen DA, Hu, Frank B, Sun, Qi, Rimm, Eric B, Willett, Walter C, Iso, Hiroyasu, Kitamura, Akihiko, Yamagishi, Kazumasa, Noda, Hiroyuki, Goldbourt, Uri, Vartiainen, Erkki, Jousilahti, Pekka R, Harald, Kennet, Salomaa, Veikko, Kauhanen, Jussi, Salonen, Jukka T, Kurl, Sudhir, Tuomainen, Tomi-Pekka, Poppelaars, Jan L, Deeg, Dorly JH, Visser, Marjolein, Meade, Tom W, De Stavola, Bianca Lucia, Hedblad, Bo, Nilsson, Peter, Engström, Gunnar, Verschuren, WM Monique, Blokstra, Anneke, de Boer, Ian H, Shea, Steven J, Meisinger, Christa, Thorand, Barbara, Koenig, Wolfgang, Döring, Angela, Verschuren, WM Monique, Blokstra, Anneke, Bueno-de-Mesquita, H Bas, Wilhelmsen, Lars, Rosengren, Annika, Lappas, Georgios, Fletcher, Astrid, Nitsch, Dorothea, Kuller, Lewis H, Grandits, Greg, Tverdal, Aage, Selmer, Randi, Nystad, Wenche, Mussolino, Michael, Gillum, Richard F, Hu, Frank B, Sun, Qi, Manson, JoAnn E, Rimm, Eric B, Hankinson, Susan E, Meade, Tom W, De Stavola, Bianca Lucia, Cooper, Jackie A, Bauer, Kenneth A, Davidson, Karina W, Kirkland, Susan, Shaffer, Jonathan A, Shimbo, Daichi, Kitamura, Akihiko, Iso, Hiroyasu, Sato, Shinichi, Holme, Ingar, Selmer, Randi, Tverdal, Aage, Nystad, Wenche, Nakagawa, Hidaeki, Miura, Katsuyuki, Sakurai, Masaru, Ducimetiere, Pierre, Jouven, Xavier, Bakker, Stephan JL, Gansevoort, Ron T, van der Harst, Pim, Hillege, Hans L, Crespo, Carlos J, Garcia-Palmieri, Mario R, Kee, Frank, Amouyel, Philippe, Arveiler, Dominique, Ferrières, Jean, Schulte, Helmut, Assmann, Gerd, Jukema, J Wouter, de Craen, Anton JM, Sattar, Naveed, Stott, David J, Cantin, Bernard, Lamarche, Benoît, Després, Jean-Pierre, Dagenais, Gilles R, Barrett-Connor, Elizabeth, Bergstrom, Jaclyn, Bettencourt, Richele R, Buisson, Catherine, Gudnason, Vilmundur, Aspelund, Thor, Sigurdsson, Gunnar, Thorsson, Bolli, Trevisan, Maurizio, Hofman, Albert, Ikram, M Arfan, Tiemeier, Henning, Witteman, Jacqueline CM, Tunstall-Pedoe, Hugh, Tavendale, Roger, Lowe, Gordon DO, Woodward, Mark, Devereux, Richard, Yeh, Jeun-Liang, Ali, Tauqeer, Calhoun, Darren, Ben-Shlomo, Yoav, Davey-Smith, George, Onat, Altan, Can, Günay, Nakagawa, Hidaeki, Sakurai, Masaru, Nakamura, Koshi, Morikawa, Yuko, Njølstad, Inger, Mathiesen, Ellisiv B, Løchen, Maja-Lisa, Wilsgaard, Tom, Sundström, Johan, Ingelsson, Erik, Michaëlsson, Karl, Cederholm, Tommy, Gaziano, J Michael, Buring, Julie, Ridker, Paul M, Gaziano, J Michael, Ridker, Paul M, Ulmer, Hanno, Diem, Günter, Concin, Hans, Rodeghiero, Francesco, Tosetto, Alberto, Wassertheil-Smoller, Sylvia, Manson, JoAnn E, Marmot, Michael, Clarke, Robert, Fletcher, Astrid, Brunner, Eric, Shipley, Martin, Kivimaki, Mika, Ridker, Paul M, Buring, Julie, Ford, Ian, Robertson, Michele, Ibañez, Alejandro Marín, Feskens, Edith, Geleijnse, Johanna M, Kromhout, Daan, Walker, Matthew, Watson, Sarah, Alexander, Myriam, Butterworth, Adam S, Angelantonio, Emanuele Di, Franco, Oscar H, Gao, Pei, Gobin, Reeta, Haycock, Philip, Kaptoge, Stephen, Seshasai, Sreenivasa R Kondapally, Lewington, Sarah, Pennells, Lisa, Rapsomaniki, Eleni, Sarwar, Nadeem, Thompson, Alexander, Thompson, Simon G, Walker, Matthew, Watson, Sarah, White, Ian R, Wood, Angela M, Wormser, David, Zhao, Xiaohui, and Danesh, John

Published
2012
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12. Serum Immunoglobulin G Is Associated With Decreased Risk of Pancreatic Cancer in the Swedish AMORIS Study

Author

Sollie, Sam, primary, Santaolalla, Aida, additional, Michaud, Dominique S., additional, Sarker, Debashis, additional, Karagiannis, Sophia N., additional, Josephs, Debra H., additional, Hammar, Niklas, additional, Walldius, Goran, additional, Garmo, Hans, additional, Holmberg, Lars, additional, Jungner, Ingmar, additional, and Van Hemelrijck, Mieke, additional

Published
2020
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14. Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study

Author

Yiu, Andrew, Van Hemelrijck, Mieke, Garmo, Hans, Holmberg, Lars, Malmström, Håkan, Lambe, Mats, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, and Wulaningsih, Wahyu

Subjects
Male, Sweden, Cancer och onkologi, Incidence, Uric Acid, Social Class, Cancer and Oncology, Neoplasms, Population Surveillance, cancer, Humans, Female, Prospective study, Uric acid, Cancer, Research Paper, prospective study, Follow-Up Studies, Proportional Hazards Models
Abstract

Objectives: Serum uric acid has been suggested to be associated with cancer risk. We aimed to study the association between serum uric acid and cancer incidence in a large Swedish cohort. Results: A positive association was found between uric acid levels and overall cancer risk, and results were similar with adjustment for glucose, triglycerides and BMI. Hazard ratio (HR) for overall cancer for the 4th quartile of uric acid compared to the 1st was 1.08 (95% CI: 1.05-1.11) in men and 1.12 (1.09 - 1.16) in women. Site-specific analysis showed a positive association between uric acid and risk of colorectal, hepatobiliary, kidney, nonmelanoma skin, and other cancers in men and of head and neck and other cancers in women. An inverse association was observed for pulmonary and central nervous system (CNS) cancers in men and breast, lymphatic and haematological, and CNS malignancies in women. Materials and Methods: We included 493,281 persons aged 20 years and older who had a measurement of serum uric acid and were cancer-free at baseline in the AMORIS study. Multivariable Cox proportional hazards regression was used to investigate sex-specific quartiles of serum uric acid in relation to cancer risk in men and women. Analysis was further adjusted for serum glucose, triglycerides and, where available, BMI. Site-specific analysis was performed for major cancers. Conclusions: Altered uric acid levels were associated with risk of overall and some specific cancers, further indicating the potential role of uric acid metabolism in carcinogenesis.

Published
2017

15. Additional file 1: of Metabolic profiles to predict long-term cancer and mortality: the use of latent class analysis

Author

Santaolalla, Aida, Garmo, Hans, Grigoriadis, Anita, Sundeep Ghuman, Hammar, Niklas, Jungner, Ingmar, Gรถran Walldius, Lambe, Mats, Holmberg, Lars, and Hemelrijck, Mieke

Abstract

Table S1. Laboratory fully automated methods with automatic calibration were performed at one accredited laboratory (CALAB to measure the serum biomarkers examine in the study. Table S2. Panel of serum markers describing standard medical cut-offs information. Table S3. Characteristics of the study population by LCA-derived metabolic classes. (DOCX 28 kb)

Published
2019
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17. Circulating gamma-glutamyl transferase and development of specific breast cancer subtypes: findings from the Apolipoprotein Mortality Risk (AMORIS) cohort

Author

Shackshaft, Lydia, Van Hemelrijck, Mieke, Garmo, Hans, Malmström, Håkan, Lambe, Mats, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, and Wulaningsih, Wahyu

Subjects
Medicine(all), Adult, Sweden, Receptor, ErbB-2, Short Report, Breast Neoplasms, gamma-Glutamyltransferase, Middle Aged, GGT, Cohort Studies, Breast cancer, Glucose, Apolipoproteins, Receptors, Estrogen, Case-Control Studies, Population Surveillance, Odds Ratio, Humans, Female, Prospective study, skin and connective tissue diseases, Receptors, Progesterone, Triglycerides, Biomarkers, Aged
Abstract

Background Different etiological pathways may precede development of specific breast cancer subtypes and impact prevention or treatment strategies. We investigated the association between gamma-glutamyl transferase (GGT) and development of specific breast cancer subtypes based on oestrogen receptor (ER), progesterone receptor (PR) and HER2 status. Methods We included 231,283 cancer-free women in a Swedish cohort. Associations between GGT and breast cancer subtypes were investigated with nested case–control and case–case analyses. We used logistic regression models to assess serum GGT in relation to breast cancer subtype, based on individual and combined receptor status. Results Positive associations were found between serum GGT and development of ER+, ER− and PR+ breast cancers compared to controls (odds ratio (OR) 1.14 (95% confidence interval (CI) 1.08–1.19), 1.11 (1.01–1.23) and 1.18 (1.12–1.24), respectively) and of ER+/PR+ tumours. We found inverse associations between GGT levels and PR− breast cancers compared to PR+ (OR 0.87 (0.80–0.95)), between ER+/PR− tumours compared to ER+/PR+ tumours and between ER−/PR−/HER+ compared to ER+/HER2 or PR+/HER2 tumours (OR 0.55 (95% CI 0.34–0.90). Conclusion The observed associations between pre-diagnostic serum GGT and different breast cancer subtypes may indicate distinct underlying pathways and require further investigations to tease out their clinical implications. Electronic supplementary material The online version of this article (doi:10.1186/s13058-017-0816-7) contains supplementary material, which is available to authorized users.

Published
2017

21. Glucose and lipoprotein biomarkers and breast cancer severity using data from the Swedish AMORIS cohort

Author

Melvin, Jennifer C, Garmo, Hans, Holmberg, Lars, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, Lambe, Mats, and Van Hemelrijck, Mieke

Subjects
Adult, Blood Glucose, LDL cholesterol, Breast cancer (BC), Lipoproteins, Prognosis, Breast Neoplasms, Triglycerides, lcsh:RC254-282, Severity, HDL cholesterol, Risk Factors, Biomarkers, Tumor, Humans, Obesity, Apolipoprotein A-I, Aged, Total cholesterol, Sweden, Cancer och onkologi, Apolipoprotein B, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cholesterol, Cancer and Oncology, Apolipoprotein B-100, Female, lipids (amino acids, peptides, and proteins), Glucose, Research Article
Abstract

Background The lipid and glucose metabolisms are postulated as possible intermediary mechanisms in linking obesity and breast cancer (BC). Links between serum lipid and glucose biomarkers and BC risk has been observed in the Swedish Apolipoprotein MORtality RISk (AMORIS) cohort. We conducted a follow-up analysis including information on tumour characteristics. Methods One thousand eight hundred twenty-four women diagnosed with BC, with serum biomarker levels of glucose, triglycerides, cholesterol (total, HDL, and LDL), and apolipoproteins A-1 and B recorded in a routine health check at baseline were included. BC severity was split into categories (good, moderate, and poor prognosis) based on ER status, TNM stage, and age at diagnosis. Proportional odds models were used to obtain odds ratios (ORs) and 95% confidence intervals (CI), with the interval time between baseline measurement and BC diagnosis accounted for. Results Serum glucose and the ApoB/ApoA-1 ratio showed a non-statistically significant positive association with BC severity (proportional OR: 1.25 (95%CI: 0.92–1.70) for glucose (

Published
2017

24. Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival

Author

Wulaningsih, Wahyu, Holmberg, Lars, Garmo, Hans, Karagiannis, Sophia N., Ahlstedt, Staffan, Malmstrom, Håkan, Lambe, Mats, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, Ng, Tony, and Van Hemelrijck, Mieke

Subjects
Cancer och onkologi, Allergy, Cancer and Oncology, atopy, cancer, cohort, Original Research, immunoglobulin E
Abstract

Prior findings linking allergy and cancer have been inconsistent, which may be driven by diverse assessment methods. We used serum specific immunoglobulin E (IgE) against common inhalant allergens that was assessed prior to cancer diagnosis in studying this association. We selected 8,727 Swedish men and women who had measurements of serum allergen-specific IgE and total IgE between 1992 and 1996. Multivariable Cox regression using age as a timescale was performed to assess the associations of IgE sensitization, defined by any levels of serum specific IgE ≥35 kU/L, with risk of overall and specific cancers. A test for trend was performed by assigning scores derived from allergen-specific IgE levels at baseline as an ordinal scale. Kaplan–Meier curves and log-rank test were used to assess cancer survival by IgE sensitization status. During a mean follow-up of 16 year, 689 persons were diagnosed with cancer. We found an inverse association between IgE sensitization and cancer risk, with a hazard ratio (HR) of 0.83 and 95% confidence intervals (CI) of 0.70–0.99. A similar trend was seen with specific IgE scores overall (Ptrend = 0.007) and in women (Ptrend = 0.01). Although IgE sensitization was not associated with risk of common site-specific cancers, serum specific IgE scores were inversely associated with melanoma risk in men and women combined, and with risk of female breast and gynecological cancers combined. No association with survival was observed. The association between circulating IgE levels and incident cancer may point toward a role of T-helper 2 (TH2)-biased response in development of some cancers.

Published
2016

27. Serum inflammatory markers and colorectal cancer risk and survival

Author

Ghuman, Sundeep, primary, Van Hemelrijck, Mieke, additional, Garmo, Hans, additional, Holmberg, Lars, additional, Malmström, Håkan, additional, Lambe, Mats, additional, Hammar, Niklas, additional, Walldius, Göran, additional, Jungner, Ingmar, additional, and Wulaningsih, Wahyu, additional

Published
2017
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29. Cohort Profile: The AMORIS cohort

Author

Walldius, Göran, primary, Malmström, Håkan, additional, Jungner, Ingmar, additional, de Faire, Ulf, additional, Lambe, Mats, additional, Van Hemelrijck, Mieke, additional, and Hammar, Niklas, additional

Published
2017
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31. Prediagnostic serum glucose and lipids in relation to survival in breast cancer patients : a competing risk analysis

Author

Wulaningsih, Wahyu, Vahdaninia, Mariam, Rowley, Mark, Holmberg, Lars, Garmo, Hans, Malmstrom, Håkan, Lambe, Mats, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, Coolen, Anthonius C., and Van Hemelrijck, Mieke

Subjects
Cancer Research, Cancer och onkologi, Breast cancer, Glucose, Oncology, Survival, Cancer and Oncology, Genetics, Lipid, Competing risk, Latent class
Abstract

Background: Abnormal glucose and lipids levels may impact survival after breast cancer (BC) diagnosis, but their association to other causes of mortality such as cardiovascular (CV) disease may result in a competing risk problem. Methods: We assessed serum glucose, triglycerides (TG) and total cholesterol (TC) measured prospectively 3 months to 3 years before diagnosis in 1798 Swedish women diagnosed with any type of BC between 1985 and 1999. In addition to using Cox regression, we employed latent class proportional hazards models to capture any heterogeneity of associations between these markers and BC death. The latter method was extended to include the primary outcome (BC death) and competing outcomes (CV death and death from other causes), allowing latent class-specific hazard estimation for cause-specific deaths. Results: A lack of association between prediagnostic glucose, TG or TC with BC death was observed with Cox regression. With latent class proportional hazards model, two latent classes (Class I and II) were suggested. Class I, comprising the majority (81.5 %) of BC patients, had an increased risk of BC death following higher TG levels (HR: 1.87, 95 % CI: 1.01-3.45 for every log TG increase). Lower overall survival was observed in Class II, but no association for BC death was found. On the other hand, TC positively corresponded to CV death in Class II, and similarly, glucose to death from other causes. Conclusion: Addressing cohort heterogeneity in relation to BC survival is important in understanding the relationship between metabolic markers and cause-specific death in presence of competing outcomes.

Published
2015

32. Serum Calcium and the Risk of Breast Cancer: Findings from the Swedish AMORIS Study and a Meta-Analysis of Prospective Studies

Author

Wulaningsih, Wahyu, primary, Sagoo, Harkiran, additional, Hamza, Mustafa, additional, Melvin, Jennifer, additional, Holmberg, Lars, additional, Garmo, Hans, additional, Malmström, Håkan, additional, Lambe, Mats, additional, Hammar, Niklas, additional, Walldius, Göran, additional, Jungner, Ingmar, additional, and Van Hemelrijck, Mieke, additional

Published
2016
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33. Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival

Author

Wulaningsih, Wahyu, primary, Holmberg, Lars, additional, Garmo, Hans, additional, Karagiannis, Sophia N., additional, Ahlstedt, Staffan, additional, Malmstrom, Håkan, additional, Lambe, Mats, additional, Hammar, Niklas, additional, Walldius, Göran, additional, Jungner, Ingmar, additional, Ng, Tony, additional, and Van Hemelrijck, Mieke, additional

Published
2016
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34. Association between baseline serum glucose, triglycerides and total cholesterol, and prostate cancer risk categories

Author

Arthur, Rhonda, primary, Møller, Henrik, additional, Garmo, Hans, additional, Holmberg, Lars, additional, Stattin, Pår, additional, Malmstrom, Håkan, additional, Lambe, Mats, additional, Hammar, Niklas, additional, Walldius, Göran, additional, Robinson, David, additional, Jungner, Ingmar, additional, and Hemelrijck, Mieke Van, additional

Published
2016
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35. Prediagnostic serum glucose and lipids in relation to survival in breast cancer patients: a competing risk analysis

Author

Wulaningsih, Wahyu, primary, Vahdaninia, Mariam, additional, Rowley, Mark, additional, Holmberg, Lars, additional, Garmo, Hans, additional, Malmstrom, Håkan, additional, Lambe, Mats, additional, Hammar, Niklas, additional, Walldius, Göran, additional, Jungner, Ingmar, additional, Coolen, Anthonius C., additional, and Van Hemelrijck, Mieke, additional

Published
2015
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40. Serum Calcium and Risk of Gastrointestinal Cancer

Author

Wulaningsih, Wahyu, primary, Michaelsson, Karl, additional, Garmo, Hans, additional, Hammar, Niklas, additional, Jungner, Ingmar, additional, Walldius, Göran, additional, Lambe, Mats, additional, Holmberg, Lars, additional, and Van Hemelrijck, Mieke, additional

Published
2013
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42. Serum Glucose and Fructosamine in Relation to Risk of Cancer

Author

Wulaningsih, Wahyu, primary, Holmberg, Lars, additional, Garmo, Hans, additional, Zethelius, Björn, additional, Wigertz, Annette, additional, Carroll, Paul, additional, Lambe, Mats, additional, Hammar, Niklas, additional, Walldius, Göran, additional, Jungner, Ingmar, additional, and Van Hemelrijck, Mieke, additional

Published
2013
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47. O-0019SERUM CALCIUM AND RISK OF GASTROINTESTINAL CANCER.

Author

Wulaningsih, Wahyu, Michaelsson, Karl, Garmo, Hans, Hammar, Niklas, Jungner, Ingmar, Walldius, Göran, Lambe, Mats, Holmberg, Lars, and Van Hemelrijck, Mieke

Subjects
*SERUM, *CALCIUM in the body, *GASTROINTESTINAL cancer, *MEDICAL informatics, *CANCER diagnosis, *CANCER-related mortality, *ANIMAL models in research
Published
2013
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48. [Apolipoproteins are better risk markers than conventional lipids].

Author

Walldius G, Holme I, and Jungner I

Subjects
Adult, Aged, Apolipoprotein A-I blood, Apolipoproteins B blood, Biomedical Research, Female, Humans, Male, Middle Aged, Risk Factors, Apolipoproteins blood, Cardiovascular Diseases blood, Lipids blood
Published
2007

49. [Apolipoproteins are new and better risk indicators of myocardial infarction].

Author

Walldius G and Jungner I

Subjects
Cholesterol, HDL blood, Cholesterol, LDL blood, Coronary Artery Disease blood, Female, Humans, Male, Predictive Value of Tests, Prospective Studies, Reference Values, Risk Factors, Apolipoproteins A blood, Apolipoproteins B blood, Biomarkers blood, Myocardial Infarction blood
Abstract

In order to make an appropriate evaluation of cardiac risk related to lipids for a given individual, measurements of the "bad" LDL and the "good" HDL should be performed. Often a value of total cholesterol can be misleading. Cholesterol and triglycerides in the blood are bound to and transported by apolipoproteins (apo). ApoB only occurs in the atherogenic lipoproteins, mainly in LDL, whereas apoA-I is bound only to HDL. We review prospective epidemiological trials and clinical trials in which statins have been used to reduce cardiac risk. The results indicate that apoB, apoA-I, and especially the balance of apoB/apoA-I, are more closely related to cardiac risk and to clinical outcome than LDL or HDL. Methodological advantages speak in favour of measuring apoB and apoA-I in clinical practice.

Published
2004

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