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Your search keyword '"Joaquim Nebot"' showing total 2 results
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2 results on '"Joaquim Nebot"'

1. Stereoselective synthesis of highly functionalized structures from lactate-derived halo ketones

Author

Fèlix Urpí, Pedro Romea, and Joaquim Nebot

Subjects
chemistry.chemical_classification, Ketone, Molecular Structure, Organic Chemistry, Stereoisomerism, Ketones, Aldehyde, Combinatorial chemistry, Chemical synthesis, chemistry, Aldol reaction, Nucleophile, Organic chemistry, Molecule, Stereoselectivity, Aldol condensation, Lactic Acid
Abstract

Highly diastereoselective (i-PrO)(2)TiCl(2)-mediated aldol reactions from lactate-derived alpha'-halo alpha-silyloxy ketones and subsequent treatment of the resultant aldols with a wide range of nucleophiles furnishes highly functionalized arrangements useful in natural product syntheses.

Published
2009

2. Highly Stereoselective Aldol Reaction Based on Titanium Enolates from (S)-1-Benzyloxy-2-methyl-3-pentanone

Author

Joan G. Solsona, Joaquim Nebot, Pedro Romea, and Fèlix Urpí

Subjects
chemistry.chemical_classification, Reaction mechanism, organic chemicals, Organic Chemistry, Diastereomer, chemistry.chemical_element, Pentanone, General Medicine, 3-Pentanone, Keto–enol tautomerism, Aldehyde, Medicinal chemistry, Adduct, chemistry.chemical_compound, nervous system, chemistry, Aldol reaction, Organic chemistry, Aldol condensation, Stereoselectivity, Titanium
Abstract

Alternative titanium-mediated aldol procedures based on several protected beta-hydroxy ethyl ketones have been surveyed. Eventually, enolization of (S)-1-benzyloxy-2-methyl-3-pentanone (1) with (i-PrO)TiCl3/i-Pr2NEt provided a very reactive enolate that afforded the corresponding 2,4-syn-4,5-syn aldol adducts in high yields and diastereomeric ratios with a broad range of aldehydes.

Published
2005

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