1. The role of N-glycosylation modification in the pathogenesis of liver cancer
- Author
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Mengyu Hu, Rui Zhang, Jiaren Yang, Chenshu Zhao, Wei Liu, Yuan Huang, Hao Lyu, Shuai Xiao, Dong Guo, Cefan Zhou, and Jingfeng Tang
- Subjects
Cytology ,QH573-671 - Abstract
Abstract N-glycosylation is one of the most common types of protein modifications and it plays a vital role in normal physiological processes. However, aberrant N-glycan modifications are closely associated with the pathogenesis of diverse diseases, including processes such as malignant transformation and tumor progression. It is known that the N-glycan conformation of the associated glycoproteins is altered during different stages of hepatocarcinogenesis. Characterizing the heterogeneity and biological functions of glycans in liver cancer patients will facilitate a deeper understanding of the molecular mechanisms of liver injury and hepatocarcinogenesis. In this article, we review the role of N-glycosylation in hepatocarcinogenesis, focusing on epithelial-mesenchymal transition, extracellular matrix changes, and tumor microenvironment formation. We highlight the role of N-glycosylation in the pathogenesis of liver cancer and its potential applications in the treatment or diagnosis of liver cancer.
- Published
- 2023
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