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Your search keyword '"Jianqi Liang"' showing total 3 results
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3 results on '"Jianqi Liang"'

1. SGLT2 inhibitors: a novel therapy for cognitive impairment via multifaceted effects on the nervous system

Author

Jiaqi Mei, Yi Li, Liyan Niu, Ruikai Liang, Mingyue Tang, Qi Cai, Jingdong Xu, Deju Zhang, Xiaoping Yin, Xiao Liu, Yunfeng Shen, Jianping Liu, Minxuan Xu, Panpan Xia, Jitao Ling, Yuting Wu, Jianqi Liang, Jing Zhang, and Peng Yu

Subjects
Cognitive impairment, Diabetes, Sodium-glucose cotransporter-2, SGLT2 inhibitor, Neuron, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract The rising prevalence of diabetes mellitus has casted a spotlight on one of its significant sequelae: cognitive impairment. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally developed for diabetes management, are increasingly studied for their cognitive benefits. These benefits may include reduction of oxidative stress and neuroinflammation, decrease of amyloid burdens, enhancement of neuronal plasticity, and improved cerebral glucose utilization. The multifaceted effects and the relatively favorable side-effect profile of SGLT2 inhibitors render them a promising therapeutic candidate for cognitive disorders. Nonetheless, the application of SGLT2 inhibitors for cognitive impairment is not without its limitations, necessitating more comprehensive research to fully determine their therapeutic potential for cognitive treatment. In this review, we discuss the role of SGLT2 in neural function, elucidate the diabetes-cognition nexus, and synthesize current knowledge on the cognitive effects of SGLT2 inhibitors based on animal studies and clinical evidence. Research gaps are proposed to spur further investigation.

Published
2024
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3. Rapid One-Pot Detection of SARS-CoV-2 Based on a Lateral Flow Assay in Clinical Samples

Author

Liping Qiu, Hua Wang, Da Han, Wei Chen, Tingting Zheng, Chao Zhang, Weihong Tan, Xiaoye Huang, and Jianqi Liang

Subjects
2019-20 coronavirus outbreak, Time Factors, Letter, Chemistry, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Point-of-care testing, 010401 analytical chemistry, Loop-mediated isothermal amplification, Outbreak, Diagnostic test, COVID-19, Nucleic acid amplification technique, 010402 general chemistry, 01 natural sciences, Virology, 0104 chemical sciences, Analytical Chemistry, Workflow, COVID-19 Testing, Molecular Diagnostic Techniques, Infectious disease (medical specialty), Point-of-Care Testing, Humans, Nucleic Acid Amplification Techniques
Abstract

Rapid tests for pathogen identification and spread assessment are critical for infectious disease control and prevention. The control of viral outbreaks requires a nucleic acid diagnostic test that is sensitive and simple and delivers fast and reliable results. Here, we report a one-pot direct reverse transcript loop-mediated isothermal amplification (RT-LAMP) assay of SARS-CoV-2 based on a lateral flow assay in clinical samples. The entire contiguous sample-to-answer workflow takes less than 40 min from a clinical swab sample to a diagnostic result without professional instruments and technicians. The assay achieved an accuracy of 100% in 12 synthetic and 12 clinical samples compared to the data from PCR-based assays. We anticipate that our method will provide a universal platform for rapid and point-of-care detection of emerging infectious diseases.

Published
2021

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