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Evaluation of the suitability of university ladder classroom environment on humans is an effective approach to improve the quality of the indoor environment and protect human health. However, there are unresolved issues regarding the suitability of university ladder classroom environment for humans. For example, the design of enclosure structure and heating ventilation and air conditioning (HVAC) system is unreasonable, and the indoor air quality does not meet the required standard. In this study, the suitability of university ladder classroom environment on humans was considered the research object. The evaluation indices of indoor environment were selected from indoor air quality, indoor thermal and humid environments, light environment, and sound environment. And the health and comfort of users were taken as the evaluation indices of users. According to the results of expert investigations and case measurements, the index weight was determined by the expert-entropy weight method, and a complete evaluation system of indices was built. There were two first-level, six second-level, and fourteen third-level indices in the evaluation system. The evaluation indices of each level with the largest weight were indoor environment (0.5940), user health (0.2530), and indoor temperature (0.1175) respectively. By comparing the actual learning effect to the evaluation results, the applicability of the evaluation system was determined. The evaluation system of the suitability of university ladder classroom environment on humans is convenient for operators to identify the weak points between humans and the environment. The evaluation system is endowed with important theoretical and practical significance to realize the green development of colleges and universities and build an environment-friendly campus.

Abstract Background We present a case report on desquamative gingivitis diagnosed as linear IgA disease (LAD), which is a rare autoimmune bullous disease exclusively affecting the oral gingiva. The oral mucosa can be impacted by various autoimmune bullous diseases, and our report focuses on this particular manifestation of LAD. Case presentation This patient presented with atypical symptoms, as frequent blister formation on the gingiva was the primary clinical manifestation. A combination of systemic and local treatment was administered to the patient. Following the treatment, there was a significant improvement observed in both the erythema and the bullous lesions on the gingiva. Conclusions A more suitable local treatment strategy should be formulated for patients presenting with oral topical lesions, which clinicians can employ effectively.

Two-dimensional [Formula: see text]-In2Se3 exhibits simultaneous intercorrelated in-plane and out-of-plane polarization, making it a highly promising material for use in memories, synapses, sensors, detectors, and optoelectronic devices. With its narrow bandgap, [Formula: see text]-In2Se3 is particularly attractive for applications in photodetection. However, relatively little research has been conducted on the out-of-plane photoconductive and bulk photovoltaic effects in [Formula: see text]-In2Se3. This limits the potential of [Formula: see text]-In2Se3 in the device innovation and performance modification. Herein, we have developed an [Formula: see text]-In2Se3-based heterojunction with a transparent electrode of two-dimensional Ta2NiS5. The out-of-plane electric field can effectively separate the photo-generated electron–hole pairs in the heterojunction, resulting in an out-of-plane responsivity (R), external quantum efficiency (EQE), and specific detectivity ([Formula: see text]) of 0.78[Formula: see text]mA/W, 10[Formula: see text]% and [Formula: see text] Jones, respectively. The out-of-plane bulk photovoltaic effect has been demonstrated by changes in the short circuit current (SCC) and open circuit voltage ([Formula: see text]) with different optical power intensity and temperature, which indicates that [Formula: see text]-In2Se3-based heterojunctions has application potential in mid-far infrared light detection based on its out-of-plane photoconductive and bulk photovoltaic effects. Although the out-of-plane photoconductive and bulk photovoltaic effects are relatively lower than that of traditional materials, the findings pave the way for a better understanding of the out-of-plane characteristics of two-dimensional [Formula: see text]-In2Se3 and related heterojunctions. Furthermore, the results highlight the application potential of [Formula: see text]-In2Se3 in low-power device innovation and performance modification.

IntroductionThe Yangtze vole (Microtus fortis) is a small herbivorous rodent that usually causes damage to crops and forests in China. Various measures were used to control their population including chemical rodenticides. However, rodenticides may cause secondary damage to the environment and the ecosystem. Therefore, the development of new rodent sterilants is urgent. Considering that some compounds of paper mulberry leaves have been verified that can inhibit the biosynthesis of sexual hormone, we aimed to explore the antifertility effect of paper mulberry leaves on M. fortis.MethodsIn this study, voles were divided into three groups including a male group, a female group, and a breeding group, and paper mulberry leaves were added into basal fodder of voles maintained in laboratory, of which the proportion of leaf weight was 50%. In each group, voles were fed with mixed fodder as treatment (BP) and voles were fed with basal fodder as contrast (CK).Results and discussionAfter feeding for more than 1 month, the results indicated that paper mulberry leaves attracted voles to feed, but inhibited their growth and reproduction. Since the second week, food intakes of BP have been significantly higher than CK (p< 0.05). However, weights of voles in male and female groups were 72.283 ± 7.394 g and 49.717 ± 2.278 g in the fifth week, and both were significantly reduced compared with their original weight (p< 0.05). Meanwhile, testicular volumes of male voles fed with BP were significantly smaller than CK (former: 318.000 ± 44.654 mm3, latter: 459.339 ± 108.755 mm3); the testosterone level, sperm number, and vitality of BP were obviously weaker than CK. Female uteruses and oophoron of BP grew slower, and the organ coefficients of uterus and oophoron fed BP were both significantly lower than CK (p< 0.05). The first reproduction of BP couple voles spent 45 days, while CK spent only 21 days. These results suggest that paper mulberry leaves could be the potential resource to produce sterilants to control rodent populations by delaying their sexual growth and reproduction. If it was practical, the apparent advantages of paper mulberry are that it is an abundant resource and the inhibitory effect could be effective in both male and female individuals. Our conclusion also supports the transformation of rodent management from lethal management to fertility control, which would be more ecologically friendly to agriculture and the ecosystem.

Abstract Walnut (Juglans regia L.) is an important woody oil plant and will be affected by abiotic and biological stress during its growth and development. The WD‐repeat (WD40) protein is widely involved in plant growth, development, metabolism, and abiotic stress response. To explore the stress response mechanism of walnut, based on the complete sequencing results of the walnut genome, this study identified and analyzed the physiological, biochemical, genetic structure, and conservative protein motifs of 42 JrWD40 genes, whose expression to abnormal temperature were tested to predict the potential biological function. The results showed that the open reading frame (ORF) of theseWD40 genes were 807–2,460 bp, encoding peptides were 29,610.55–90,387.98 Da covering 268–819 amino acids, as well as 12–112 phosphorylation sites. JrWD40 proteins were highly conserved with four to five WD40 domains and shared certain similarity to WD40 proteins from Arabidopsis thaliana (L.) Heynh. JrWD40 genes can be induced to varying degrees by low and high temperature treatments. JrWD40‐32, JrWD40‐27, JrWD40‐35, and JrWD40‐21 are affected by high temperature more seriously and their expression levels are higher; while JrWD40‐37, JrWD40‐26, JrWD40‐20, JrWD40‐24, and other genes are inhibited under low temperature stress. JrWD40‐40, JrWD40‐28, and JrWD40‐18 were first suppressed with low expression, while as the treatment time prolonging, the expression level was increased under cold condition. JrWD40‐14, JrWD40‐18, JrWD40‐34, and JrWD40‐3 displayed strong transcriptions response to both heat and cold stress. These results indicated that JrWD40 genes can participate in walnut adaptation to adversity and can be used as important candidates for walnut resistance molecular breeding.

Late Pleistocene Labrador Sea depositional systems developed in front of ice streams and glacier outlets from the Laurentide Ice Sheet (LIS) are documented by Huntec and 3.5 kHz seismic profiles and piston cores. Due to efficient grinding by the LIS, massive amounts of fine-grained sediments and meltwater in addition to the icebergs linked to the Heinrich events (H events) of the last glaciation were delivered to the neighboring Labrador Sea. The position of the Hudson Strait ice stream during the periodic expansion and contraction on the Labrador margin allowed fine-grained sediments and meltwater direct delivery on the lower shelf and upper slope. These discharges were then transported southward by the Labrador Current and western boundary current. In contrast to the lower shelf and upper slope, sediments delivered on the mid to the lower Labrador Slope were transported by the Northwest Atlantic Mid-Ocean Channel to distal sites. The nepheloid flow layer at or near the sea bottom or at mid-water depths developed from meltwater loaded with an excessive charge of fine-grained sediments. Contrastingly, the non-discriminatory ice rafting process delivered detritus of all sizes, but its total contribution to the sediment column was only minor, notwithstanding its paleoclimatic significance during H events. Heinrich H1, H2, and H4 layers were identified by their characteristic nepheloid flow layer deposits, that is, alternating coarse silt and clay-sized laminae with thin ice-rafted debris interspersed by coarse- to fine-grained dropstone. Furthermore, the progressive thinning and eventual disappearance of the fine-laminae (i.e., coarse and fine silt/clay) in H layers at the distal sites suggest the exhaustion and raining out of fines due to long-distance transport. However, the H3 layer was identified by a combination of nepheloid flow layer deposits (upper slope) and finely laminated mud turbidites (lower slope and deep basin) at proximal sites. In the lower Labrador Slope and Basin, the H3 stratigraphic equivalent layer was identified by exorbitantly thick finely laminated carbonate-rich mud turbidites. The divergent sedimentation style (i.e., reflected by the sediment facies) and the thickness of the H3 layer compared to other H events suggest that the Hudson Strait ice stream position was different from other H events. Therefore, our data imply that the divergence in the H3 layer between the eastern and western North Atlantic might lie with the position of the Hudson Strait ice stream on the Labrador continental margin.

Soil heavy-metal pollution is one of the most important environmental problems in the world, and seriously endangers plant growth and human health. Microbial remediation has become a key technology in the field of soil heavy-metal remediation due to its advantages of being harmless, green and environmental. In this study, a fungus Penicillium spp. XK10 with high tolerance to cadmium (Cd) and antimony (Sb) was screened from mine slag, and its adsorption characteristics to heavy metals under different environmental conditions were studied. The results showed that at pH0 = 6, C0 (Cd) = 0.1 mM, and the adsorption time was 4 days, the maximum removal rate of cadmium by XK10 was 32.2%. Under the conditions of pH0 = 4, T = 7d, and the initial antimony concentration of 1 mM, the removal rate of antimony by XK10 was the highest, which was 15.5%. This study provides potential microbial materials for bioremediation of heavy metal-contaminated soils.

Background. Acute kidney injury (AKI) has long been recognized as a common and important complication of acute pancreatitis (AP). In the study, machine learning (ML) techniques were used to establish predictive models for AKI in AP patients during hospitalization. This is a retrospective review of prospectively collected data of AP patients admitted within one week after the onset of abdominal pain to our department from January 2014 to January 2019. Eighty patients developed AKI after admission (AKI group) and 254 patients did not (non-AKI group) in the hospital. With the provision of additional information such as demographic characteristics or laboratory data, support vector machine (SVM), random forest (RF), classification and regression tree (CART), and extreme gradient boosting (XGBoost) were used to build models of AKI prediction and compared to the predictive performance of the classic model using logistic regression (LR). XGBoost performed best in predicting AKI with an AUC of 91.93% among the machine learning models. The AUC of logistic regression analysis was 87.28%. Present findings suggest that compared to the classical logistic regression model, machine learning models using features that can be easily obtained at admission had a better performance in predicting AKI in the AP patients.

Diaphyseal cross-sectional geometry (CSG) is an effective indicator of humeral bilateral asymmetry. However, previous studies primarily focused on CSG properties from limited locations to represent the overall bilateral biomechanical performance of humeral diaphysis. In this study, the complete humeral diaphyses of 40 pairs of humeri from three Chinese archaeological populations were scanned using high-resolution micro-CT, and their biomechanical asymmetries were quantified by morphometric mapping. Patterns of humeral asymmetry were compared between sub-groups defined by sex and population, and the representativeness of torsional rigidity asymmetry at the 35% and 50% cross-sections (J35 and J50 asymmetry) was testified. Inter-group differences were observed on the mean morphometric maps, but were not statistically significant. Analogous distribution patterns of highly asymmetrical regions, which correspond to major muscle attachments, were observed across nearly all the sexes and populations. The diaphyseal regions with high variability of bilateral asymmetry tended to present a low asymmetrical level. The J35 and J50 asymmetry were related to the overall humeral asymmetry, but the correlation was moderate and they could not reflect localized asymmetrical features across the diaphysis. This study suggests that the overall asymmetry pattern of humeral diaphysis is more complicated than previously revealed by individual sections.

Background Regional diversity in the morphology of the H. erectus postcranium is not broadly documented, in part, because of the paucity of Asian sites preserving postcranial fossils. Yet, such an understanding of the initial hominin taxon to spread throughout multiple regions of the world is fundamental to documenting the adaptive responses to selective forces operating during this period of human evolution. Methods The current study reports the first humeral rigidity and strength properties of East Asian H. erectus and places its diaphyseal robusticity into broader regional and temporal contexts. We estimate true cross-sectional properties of Zhoukoudian Humerus II and quantify new diaphyseal properties of Humerus III using high resolution computed tomography. Comparative data for African H. erectus and Eurasian Late Pleistocene H. sapiens were assembled, and new data were generated from two modern Chinese populations. Results Differences between East Asian and African H. erectus were inconsistently expressed in humeral cortical thickness. In contrast, East Asian H. erectus appears to exhibit greater humeral robusticity compared to African H. erectus when standardizing diaphyseal properties by the product of estimated body mass and humeral length. East Asian H. erectus humeri typically differed less in standardized properties from those of side-matched Late Pleistocene hominins (e.g., Neanderthals and more recent Upper Paleolithic modern humans) than did African H. erectus, and often fell in the lower range of Late Pleistocene humeral rigidity or strength properties. Discussion Quantitative comparisons indicate that regional variability in humeral midshaft robusticity may characterize H. erectus to a greater extent than presently recognized. This may suggest a temporal difference within H. erectus, or possibly different ecogeographical trends and/or upper limb loading patterns across the taxon. Both discovery and analysis of more adult H. erectus humeri are critical to further evaluating and potentially distinguishing between these possibilities.