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Abstract The growth of artificial intelligence leads to a computational burden in solving non-deterministic polynomial-time (NP)-hard problems. The Ising computer, which aims to solve NP-hard problems faces challenges such as high power consumption and limited scalability. Here, we experimentally present an Ising annealing computer based on 80 superparamagnetic tunnel junctions (SMTJs) with all-to-all connections, which solves a 70-city traveling salesman problem (TSP, 4761-node Ising problem). By taking advantage of the intrinsic randomness of SMTJs, implementing global annealing scheme, and using efficient algorithm, our SMTJ-based Ising annealer outperforms other Ising schemes in terms of power consumption and energy efficiency. Additionally, our approach provides a promising way to solve complex problems with limited hardware resources. Moreover, we propose a cross-bar array architecture for scalable integration using conventional magnetic random-access memories. Our results demonstrate that the SMTJ-based Ising computer with high energy efficiency, speed, and scalability is a strong candidate for future unconventional computing schemes.

In Bandpass Sampling Fourier Transform Spectroscopy, a comprehensive method for evaluating signal-to-noise ratio (SNR) has not yet been established. This paper employs an energy conservation approach to analyze the relationship of SNR between interferogram and spectra in Bandpass Sampling Time-Modulated Fourier Transform Spectroscopy (BPS-FTS). It systematically presents models for the average SNR of the system interferogram and the average SNR of reconstructed spectra under different parameters. These models are compared with SNR models in traditional Fourier transform spectroscopy (FTS) and are mutually validated through theoretical modeling and simulation analysis. It provides a theoretical basis and simulation verification for the design and implementation of the system.

Curcumin, a naturally occurring poorly water-soluble polyphenol with a broad spectrum, is a typical BCS IV drug. The objective of this study was to develop curcumin nanocrystals liposomes with the aim of improving bioavailability. In this study, we prepared cationic curcumin nanocrystals with a particle size of only 29.42 nm; such a phenomenal range of particle sizes is very rare. Moreover, we summarized and evaluated the parameters of the nanocrystal preparation process, including methods, formulations, etc., and the rules we concluded can be generalized to other nanocrystal preparation processes. To counteract the instability of the nanocrystals in the digestive tract, cationic curcumin nanocrystals were loaded into negatively charged liposomes through gravitational force between different charges. Unexpectedly, chitosan oligosaccharide was found to promote the self-assembly process of curcumin nanocrystal liposomes. In vitro and in vivo experiments demonstrated that chitosan-modified curcumin nanocrystal liposomes exhibited enhanced resistance to enzyme barriers, mucus barriers, and cellular barriers, resulting in a 5.4-fold increase in bioavailability compared to crude powder formulations. It can be concluded that cationic nanocrystals liposomes represent an appropriate novel strategy for improving the dissolution rate and bioavailability of poorly soluble natural products such as curcumin.

In August 2018, tropical cyclone (TC) Yagi rapidly intensified as it passed over an oceanic mesoscale anticyclonic eddy (eddy) in the East China Sea, increasing in TC intensity from a tropical storm to a severe tropical storm. The maximum surface wind speed increase (minimum sea level pressure decrease) of Yagi over sea surface temperature (SST) warm anomalies caused by the eddy accounted for 66.7% (36.4%) of the whole case. Regional atmospheric model experiments are conducted to aid the interpretations of the case of Yagi intensifying over the eddy. Model results indicate that the SST warm anomalies caused by the eddy increase and concentrate the heat flux transported from the ocean to the atmosphere, and the upper air warms up, which is conducive to the development of convection. As a result, the contribution of the eddy to TC enhancement is over 20% in the period over the eddy and the precipitation is more concentrated at the TC center. The model further showed that the eddy affects the TC, resulting in more favorable dynamic and thermal conditions around the TC after landfall for the formations of TC tornadoes.

For traditional Fourier transform (FTS), its integral sampling usually meets the Spectral Modulation Transfer Function (SMTF) criterion. However, for bandpass-sampling Fourier transform spectroscopy (BPS-FTS), based on our analysis, the integral sampling condition derived from the Spectral Modulation Transfer Function (SMTF) is excessively stringent. In other words, the interval of the integral sampling time that fulfills the tolerance requirements for the reconstructed spectrum is very narrow. There are numerous integration sampling time intervals outside this range that still meet the tolerance requirements for the reconstructed spectrum. In this paper, through theoretical modeling, we propose a method based on average |SMTF| as the selection criterion for the integration sampling time. Through simulation analysis, it is evident that the intervals and range of the integral sampling time obtained via this method are more accurate, ensuring the tolerance requirements of the reconstructed spectrum. Under these intervals, when conducting integral sampling on the interferogram, the spectral deviation of the reconstructed spectrum is minimal, and the Spectral Correlation Mapper (SCM) is nearly equal to one. This indicates that compared with the SMTF criterion in traditional FTS, this method is more suitable for the characteristics of BPS-FTS. The analysis in this paper can provide theoretical and simulation support for the implementation of BPS-FTS.

Ex vivo-expanded mesenchymal stem cells (MSCs) have been demonstrated to be a heterogeneous mixture of cells exhibiting varying proliferative, multipotential, and immunomodulatory capacities. However, the exact characteristics of MSCs remain largely unknown. By single-cell RNA sequencing of 61,296 MSCs derived from bone marrow and Wharton’s jelly, we revealed five distinct subpopulations. The developmental trajectory of these five MSC subpopulations was mapped, revealing a differentiation path from stem-like active proliferative cells (APCs) to multipotent progenitor cells, followed by branching into two paths: 1) unipotent preadipocytes or 2) bipotent prechondro-osteoblasts that were subsequently differentiated into unipotent prechondrocytes. The stem-like APCs, expressing the perivascular mesodermal progenitor markers CSPG4/MCAM/NES, uniquely exhibited strong proliferation and stemness signatures. Remarkably, the prechondrocyte subpopulation specifically expressed immunomodulatory genes and was able to suppress activated CD3+ T cell proliferation in vitro, supporting the role of this population in immunoregulation. In summary, our analysis mapped the heterogeneous subpopulations of MSCs and identified two subpopulations with potential functions in self-renewal and immunoregulation. Our findings advance the definition of MSCs by identifying the specific functions of their heterogeneous cellular composition, allowing for more specific and effective MSC application through the purification of their functional subpopulations.

Objective To study the accuracy of Nolla method for age estimation of Northern Chinese Han children aged between 5.00 and 14.99 years based on original transformation tables and multiple regression model. Methods A total of 2 000 orthopantomographs （OPGs） were collected from the Hospital of Stomatology, Xi’an Jiaotong University, including 1 000 males and 1 000 females. Development stage of 7 left mandibular permanent teeth （except third molars） was assessed based on Nolla method, then age estimation was conducted through transformation tables and multiple regression model, respectively. Firstly, the development stage results of 7 permanent teeth were added up and the estimated age was obtained through the original transformation tables. Secondly, 80% of the samples （80 males and 80 females in each age group） were randomly selected from 2 000 OPGs as the train set. The chronological age of the selected patients was taken as the dependent variable, while gender and the development stage results of 7 permanent teeth were taken as the independent variable to establish multiple regression model. The remaining 20% of the samples were substituted into the model as the test set, to verify the accuracy of age estimation by multiple regression model. Results Mean chronological ages of males and females were 10.03±0.09 years and 10.01±0.09 years, respectively. The age estimated by original transformation tables showed an overestimation for males （0.18 years on average） and an underestimation for females （0.02 years on average）, with mean absolute error （MAE） of 0.94 years and 0.97 years, respectively. While the results by multiple regression model showed that males were overestimated by 0.06 years on average and females were underestimated by 0.02 years on average. The MAE was 0.66 years and 0.77 years, respectively. Conclusion The Nolla method is suitable for age estimation of Northern Chinese Han children. Compared with the original transformation tables method, the multiple regression model is more accurate for age estimation.

Fourier transform spectroscopy with bandpass sampling (BPS-FTS) increases the interferogram sampling step and reduces sampling frequency, thereby reducing system implementation difficulty. However, this technology has only been introduced in principle and lacks analysis of the actual system error. In this paper, we present a theoretical analysis of the optical system diffraction effect, derive the bandpass spectrum bandwidth and interferogram sampling step under the influence of the diffraction effect, and conduct modeling and a simulation analysis with and without the diffraction effect. Through simulation, we found that when the diffraction effect was considered, the relative deviation of the recovered spectrum from the input spectrum was 1.30%, and the spectral similarity was 0.9669. However, without considering the diffraction effect, the relative deviation of the recovered spectrum from the input spectrum was 6.23%, and the spectral similarity was only −0.0056. The simulation results demonstrate that the diffraction effect has a significant influence on BPS-FTS interferogram sampling and recovery spectra. The results of this study have reference significance for their technical realization of BPS-FTS.

LL-37, the C-terminal peptide of human cathelicidin antimicrobial peptide (CAMP, hCAP18), reportedly increases resistance to microbial invasion and exerts important physiological functions in chemotaxis, promotion of wound closure, and angiogenesis. Accumulating evidence indicates that LL-37 also plays a significant role in human cancer. LL-37 induces tumorigenic effects in cancers of the ovary, lung, breast, prostate, pancreas, as well as in malignant melanoma and skin squamous cell carcinoma. In contrast, LL-37 displays an anti-cancer effect in colon cancer, gastric cancer, hematologic malignancy and oral squamous cell carcinoma. Mechanistically, LL-37-induced activation of membrane receptors and subsequent signaling pathways lead to alteration of cellular functions. Different membrane receptors on various cancer cells appear to be responsible for the tissue-specific effects of LL-37. Meanwhile, the findings that vitamin D-dependent induction of cathelicidin in human macrophages activates the anti-cancer activity of tumor-associated macrophages (TAMs) and enhances antibody-dependent cellular cytotoxicity (ADCC) support critical roles of vitamin D-dependent induction of cathelicidin in cancer progression. This review describes novel advances involving the roles and mechanisms of human cathelicidin LL-37 in cancer.

The initial processing of Citrus Reticulata 'Chachi' involves peeling as a crucial step. Currently, there is some semi-automatic peeling equipment available. However, due to the requirement of adjusting the orientation of Citrus Reticulata 'Chachi' to ensure the stem (or navel) is facing upwards before peeling and because the peeling process must retain the stem as a marker for fresh fruit picking, the loading of Citrus Reticulata 'Chachi' for peeling still solely relies on manual operation, resulting in low efficiency and poor standardization. With the rapid growth of the pericarp of the Citrus Reticulata 'Chachi' industry, semi-automatic processing equipment is no longer able to meet production demands. The loading issue before peeling Citrus Reticulata 'Chachi' is a complex hand–eye coordination problem. In response to this issue, this paper proposes a novel Citrus Reticulata 'Chachi' orientation adjustment mechanism (COAM). This mechanism utilizes frictional force to adjust the orientation of Citrus Reticulata 'Chachi'. First, the conceptual design and kinematic modelling analysis of the mechanism were conducted. Next, the omnidirectional friction-driven wheels were optimized in design. Subsequently, a prototype was manufactured and assembled to conduct validation tests on its open-loop motion performance. Finally, a visual feedback-guided algorithm was introduced to complement the kinematic model, enabling the automatic and rapid adjustment of Citrus Reticulata 'Chachi' orientation. The experimental results indicate that the COAM designed in this study can effectively and rapidly adjust the orientation of Citrus Reticulata 'Chachi' fruits of different sizes and shapes. It demonstrates strong adaptability, and under visual feedback guidance, the orientation adjustment error is less than 10% of the fruit's diameter. This meets the requirements for automated production in the initial processing of Citrus Reticulata 'Chachi'. The research presented in this paper also provides new insights for the orientation adjustment and loading of similar spherical fruits. [ABSTRACT FROM AUTHOR]