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Jee Eun Lee Department of Business, Korea University, Seoul, 02841, Republic of KoreaCorrespondence: Jee Eun Lee, Department of Business, Korea University, 145, Anam-Ro, Seongbuk-Gu, Seoul, 02841, Korea, Email jelee89@korea.ac.krPurpose: Based on the attribution and appraisal theories of emotion, this study investigates whether a consumer’s frustration and anger after a service failure reduces in different ways after hearing explanations from different sources (other customer vs employee vs none) under different blame attribution circumstances (situational vs service provider), and its subsequent influence on complaining intention.Methods: In Study 1, valid data from 239 participants (46.9% female, Mage=35.6 years) were used to test the interaction effect of the explanation source and blame attribution on frustration and anger. In Study 2, using valid answers from 253 students at Korea University (57.9% female, Mage=20.9 years), Study 1 was replicated and, in addition, tested the moderated mediating impact on complaining intention. The overall theoretical model was tested with ANOVA and Hayes process model 8.Results: When blame attribution was situational, the employee’s explanation did not mitigate either frustration or anger, whereas the other customer’s explanation mitigated frustration but not anger. In contrast, when blame attribution was towards the service provider, the employee’s explanation mitigated both frustration and anger, whereas the other customer’s explanation mitigated only frustration. In addition, the mitigation of frustration and anger by other customers subsequently led to a decrease in complaining intention, which was stronger and only significant when blame attribution was situational. However, only anger acted as a mediator between the employee’s explanation and complaining intention, which did not vary according to blame attribution.Conclusion: The results of the study advance the current knowledge on informational support as a service recovery process by suggesting the crucial role of other consumers in mitigating the target customer’s frustration, especially under situational service failure, which successively leads to a decrease in complaining intention, whereas the employee’s explanation decreases complaining intention only through the mitigation of anger.Keywords: service recovery, other consumer’s explanation, employee’s explanation, frustration, anger

Supplemental Table 1 describes the adverse events with corresponding risk differences between treatment arms during induction of pivotal trial ALFA-0701.

On September 1, 2017, the FDA granted approval for gemtuzumab ozogamicin (Mylotarg; Pfizer Inc.) in combination with daunorubicin and cytarabine and as a monotherapy for the treatment of adult patients with newly diagnosed CD33-positive acute myeloid leukemia (AML). Gemtuzumab ozogamicin is a CD33-targeted antibody–drug conjugate joined to calicheamicin. Approval of gemtuzumab ozogamicin combination treatment was based on a randomized trial of 271 patients with newly diagnosed AML treated with daunorubicin and cytarabine with or without 3 mg/m2 fractionated gemtuzumab ozogamicin, which resulted in an event-free survival (EFS) of 13.6 months for gemtuzumab ozogamicin + daunorubicin and cytarabine and 8.8 months for daunorubicin and cytarabine alone [HR = 0.68 (95% confidence interval (CI), 0.51–0.91)]. Hemorrhage, prolonged thrombocytopenia, and veno-occlusive disease were serious toxicities that were more common in patients treated with gemtuzumab ozogamicin + daunorubicin and cytarabine. Approval of gemtuzumab ozogamicin monotherapy was based on a randomized trial of 237 patients with newly diagnosed AML treated without curative intent. Median overall survival (OS) was 4.9 months with gemtuzumab ozogamicin versus 3.6 months on best supportive care [HR = 0.69 (95% CI, 0.53–0.90)]. Adverse events were similar on both arms. Postapproval, several studies are required including evaluation of fractionated gemtuzumab ozogamicin pharmacokinetics, safety of combination gemtuzumab ozogamicin in the pediatric population, immunogenicity, and the effects of gemtuzumab ozogamicin on platelet function. Clin Cancer Res; 24(14); 3242–6. ©2018 AACR.

Supplemental Table 4 and the accompanying text describe the grouped terms used for the adverse reactions described in Table 2 and the reasons for using grouped terms.

Supplemental Table 2 describes the adverse events with corresponding risk differences between treatment arms during consolidation 1 of pivotal trial ALFA-0701.

Supplemental Table 3 describes the adverse events with corresponding risk differences between treatment arms during consolidation 2 of pivotal trial ALFA-0701.

Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these individuals. Herein, we present a case of secondary breast cancer in an LFS patient after radiation and chemotherapy for the first diagnosed breast sarcoma.

This paper investigates the mediating effects of relationship fairness factors between franchisors’ support services and franchisees’ performance. Fairness is measured using constructs of distributive, procedure, interaction, and information, franchisors’ support service is divided into initial support services and continuous support services, and performance (re-contract intention) is measured using re-contract, contract extension, and recommendation. Our findings are fourfold. First, initial support service has a significant impact on other fairness concerns, excluding distributive fairness, and support service improvement can increase perceived fairness in the franchisor–franchisee relationship. Second, procedural, and informational fairness have a positive and significant impact on franchisees’ re-contract intention. This indicates that information sharing between franchisors and franchisees must be transparent in accordance with consistent established procedures. Third, only information fairness is found to have a partial mediating effect between continuous support services and performance, and continuous support service indirectly positively affects re-contract intention through relationship fairness. Fourth, there are differences between global and domestic franchises in the impact of continuous support services on relationship fairness, as global franchises’ continuous support service appears to have a greater effect on the relationship fairness, which should be considered for global competitiveness.

Firm foot contact is the top priority of climbing robots to avoid catastrophic events, especially when working at height. This study proposes a robust planning and control framework for climbing robots that provides robustness to slippage in unknown environments. The framework includes 1) a center of mass (CoM) trajectory optimization under the estimated contact condition, 2) Kalman filter–like approach for uncertain environment parameter estimation and subsequent CoM trajectory re-planing, and 3) an online weight adaptation approach for whole-body control (WBC) framework that can adjust the ground reaction force (GRF) distribution in real time. Though the friction and adhesion characteristics are often assumed to be known, the presence of several factors that lead to a reduction in adhesion may cause critical problems for climbing robots. To address this issue safely and effectively, this study suggests estimating unknown contact parameters in real time and using the evaluated contact information to optimize climbing motion. Since slippage is a crucial behavior and requires instant recovery, the computation time for motion re-planning is also critical. The proposed CoM trajectory optimization algorithm achieved state-of-art fast computation via trajectory parameterization with several reasonable assumptions and linear algebra tricks. Last, an online weight adaptation approach is presented in the study to stabilize slippery motions within the WBC framework. This can help a robot to manage the slippage at the very last control step by redistributing the desired GRF. In order to verify the effectiveness of our method, we have tested our algorithm and provided benchmarks in simulation using a magnetic-legged climbing robot Manegto.

In this study, preclinical experiments were performed with an in-house developed prototypal photon-counting detector computed tomography (PCD CT) system. The performance of the system was compared with the conventional energy-integrating detector (EID)-based CT, concerning the basic image quality biomarkers and the respective capacities for material separation. The pre- and the post-contrast axial images of a canine brain captured by the PCD CT and EID CT systems were found to be visually similar. Multi-energy images were acquired using the PCD CT system, and machine learning-based material decomposition was performed to segment the white and gray matters for the first time in soft tissue segmentation. Furthermore, to accommodate clinical applications that require high resolution acquisitions, a small, native, high-resolution (HR) detector was implemented on the PCD CT system, and its performance was evaluated based on animal experiments. The HR acquisition mode improved the spatial resolution and delineation of the fine structures in the canine’s nasal turbinates compared to the standard mode. Clinical applications that rely on high-spatial resolution expectedly will also benefit from this resolution-enhancing function. The results demonstrate the potential impact on the brain tissue segmentation, improved detection of the liver tumors, and capacity to reconstruct high-resolution images both preclinically and clinically.

The phagophore expands into autophagosomes in close proximity to endoplasmic reticulum (ER) exit sites (ERESs). Here, we propose that a single-pass ER transmembrane protein, SHISA5/SCOTIN, acts as an autophagy suppressor under basal condition by blocking the contact between the phagophore and ERES. HeLa cells lacking SHISA5 displayed higher levels of macroautophagy/autophagy. The enhanced autophagy in SHISA5 KO cells requires class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1) activity and functional assembly of ERES, but not ULK1 activity. A proximity ligation assay (PLA) of SEC16A (Sec16 homolog A, endoplasmic reticulum export factor)-WIPI2 (WD repeat domain, phosphoinositide interacting 2) and SEC31A (Sec31 homolog A, COPII coat complex component)-MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3 beta) demonstrated that contact between the ERES and phagophore increased in SHISA5 KO cells, and the cytosolic domain of SHISA5 was sufficient to rescue this phenotype. Close proximity between ERES and phagophore in SHISA5 KO cells was also visualized by performing an ultrastructure correlative image analysis of SEC31A associated with LC3-positive membranes. Furthermore, we observed that SHISA5 was located near ERES under basal conditions, but displaced away from ERES under autophagy-inducing conditions. These data suggest that SHISA5 functions to block spontaneous contact between ERES and phagophore, and the blockage effect of SHISA5 should be relieved for the proper induction of autophagy. ABBREVIATIONS: ATG2: autophagy related 2; BECN1: beclin 1; COPII: coat protein II; DMSO: dimethyl sulfoxide; EBSS: Earle’s balanced salt solution; EGFP: enhanced green fluorescent protein; ER: endoplasmic reticulum; ERES: ER exit site(s); GFP: green fluorescent protein; H89: H-89 dihydrochloride hydrate; LAMP1: lysosomal-associated membrane protein 1; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MTORC1: mechanistic target of rapamycin kinase complex 1; NS5A: nonstructural protein 5A; PIK3C3/VPS34: phosphatidylinositol 3-kinase catalytic subunit type 3; PLA: proximity ligation assay; PtdIns3P: phosphatidylionositol-3-phosphate; RB1CC1/FIP200: RB1 inducible coiled-coil 1; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SBP: streptavidin binding protein; SEC16A: SEC16 homolog A, endoplasmic reticulum export factor; SEC31A: SEC31 homolog A, COPII coat complex component; siRNA: small interfering RNA; Str: streptavidin; ULK1: unc-51-like autophagy activating kinase 1; VSVG: vesicular stomatitis virus glycoprotein; WIPI2: WD repeat domain, phosphoinositide interacting 2; WT: wild type

Background: To evaluate how artificial intelligence-based computer-assisted diagnosis (AI-CAD) for breast ultrasound (US) influences diagnostic performance and agreements between radiologists with varying experience levels in different workflows.Methods: From Apr 2017 to Jun 2018, images of 492 breast lesions (200 malignant and 292 benign masses) in 472 women were included. Six radiologists (3 inexperienced with < 1 year of experience, 3 experienced with 10-15 years of experience) individually reviewed US images with and without the aid of AI-CAD, first in sequential and then in independent reading. Diagnostic performances and interobserver agreements were calculated and compared between radiologists and AI-CAD. Results: After implementing AI-CAD, specificity, PPV and accuracy significantly improved, regardless of experience and workflow (all P<0.001, respectively). Overall area under the receiving operator characteristics curve (AUC) significantly increased in independent reading, but only for inexperienced radiologists. Agreements for BI-RADS descriptors generally increased when AI-CAD was used (κ=0.29-0.63 to 0.35-0.73). Inexperienced radiologists tended to concede to AI-CAD results more easily than experienced radiologists, especially in independent reading (PP<0.001) for both inexperienced and experienced radiologists. Conclusions: Using AI-CAD to interpret breast US improves the specificity, PPV and accuracy of radiologists regardless of experience level. AI-CAD may work better in independent reading to improve diagnostic performance and agreements between radiologists, especially for inexperienced radiologists.Trial registration: retrospectively registered

Rhabdomyosarcoma mainly occurs in the pediatric age group, with the primary tumor originating from the trunk, neck, and extremities. Metastasis of rhabdomyosarcoma to the breast is very rare. Previous reports have suggested that the mammographic finding of breast rhabdomyosarcoma is an oval-shaped mass with irregular margins and the US finding is a solitary nodular lesion. We report a case of breast metastasis from pleural rhabdomyosarcoma in a 21-year-old woman, presenting as diffuse non-mass involvement and edematous change without a nodular mass.

This study evaluated the effects of alpha-s1 casein hydrolysate (ACH, Lactium&reg, ) on the subjective and objective sleep profiles of a community-based sample of Koreans with poor sleep quality. We performed a double-blind, randomized crossover trial with 48 participants (49.0 &plusmn, 1.7 years old, 65% female) who exhibited a mild to moderate degree of sleep disturbance. Either ACH or placebo was administered for the initial four weeks, and the counterpart was administered in precisely the same manner after a four-week washout period. Sleep disturbance scales, daytime functioning, and psychiatric aspects showed a similar tendency to improve during both ACH and placebo phases without significant group differences. Overall perceived sleep profiles in sleep diaries were significantly improved during the ACH phase, represented by increased total sleep time and sleep efficiency (SE), as well as decreased sleep latency and wake after sleep onset (WASO). Interestingly, actigraphy demonstrated significantly increased SE after continuous use of ACH for four weeks, clearly more improved when compared to two weeks of use. The polysomnography measures showed a similar tendency without statistically significant group differences. Our findings suggest that refined ACH was well tolerated and could improve sleep quality, with possible cumulative beneficial effects with long-term administration.

The purpose of this study was to determine the preferences of Korean university students among five specific types of written corrective feedback...

The purpose of this study was to explore students’ and team-teachers’ opinions on a general English team-teaching program at a Korean university. A total of 192 students and 26 team-teachers participated in this study. The participants completed a survey with 37 items, questioning their satisfaction with the program and their suggestions for effective follow-up team-teaching programs. According to the analysis of both quantitative and demographic data using the SPSS, the results of this study indicate that most of the two participant groups had above average positive perceptions of the sub-variables of the instrument related to the team-teaching program implementation. Also, there were no significant relationships between any sub-variables and demographic variables. The results of the qualitative analysis showed the participants wanted more class hours, less dependence on Korean teachers, more close collaboration between the two co-teachers through frequent interactions, and more opportunities to interact with NESTs. For future research, the authors recommend more in-depth research on team-teaching programs containing more participants and in different settings. At the end of this study, some pedagogical implications for English education were discussed.

Background: The origin of the vertebral artery (VA) is prone to be misinterpreted as having focal stenosis on computed tomography angiography (CTA) or magnetic resonance angiography (MRA) due to artifacts. Ultrasonography may be a valuable technique to reveal stenosis of the VA origin. We compared the findings for the VA origin from CTA or MRA with those from ultrasonotraphy. Methods: We consecutively enrolled patients who underwent angiography (CTA or MRA) and carotid ultrasonography. The V2 and V1 portions of the VA were insonated to evaluate the presence of plaque or steno-occlusion. CTA or MRA data were evaluated. Stenosis or occlusion of the VA origin was categorized as present or absent. The results from the two methods were compared. Results: The mean age of the 73 investigated patients was 61.1 years, and 46 (63.0%) of them were male. Among the 22 patients with steno-occlusion of the right VA on CTA or MRA, only six had stenosis on ultrasonography. Regarding the left VA, only four patients among 16 who showed steno-occlusion on CTA or MRA had steno-occlusion on ultrasonography. The level of agreement between the two methods was 82.2% on the left side and 75.3% on the right side. There were no clinical differences between the patients with and without false-positive results on CTA or MRA. Conclusions: In 16.4% (left) and 21.9% (right) of all patients, lumens with steno-occlusions observed on CTA or MRA were revealed as normal on ultrasonography. The diagnosis of VA origins could be improved by applying these two methods complementarily. J Korean Neurol Assoc 34(1):23-26, 2016