Author: "Jansson, J.O." / Search Limiters: Available in Library Collection - Searchworks@Jio Institute Digital Library Search Results

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15 results on '"Jansson, J.O."'

1. Ghrelin

Author: Müller, T.D., Nogueiras, R., Andermann, M.L., Andrews, Z.B., Anker, S.D., Argente, J., Batterham, R.L., Benoit, S.C., Bowers, C.Y., Broglio, F., Casanueva, F.F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P.A., Cowley, M., Cummings, D.E., Dagher, A., Diano, S., Dickson, S.L., Diéguez, C., Granata, R., Grill, H.J., Grove, K., Habegger, K.M., Heppner, K., Heiman, M.L., Holsen, L., Holst, B., Inui, A., Jansson, J.O., Kirchner, H., Korbonits, M., Laferrère, B., LeRoux, C.W., Lopez, M., Morin, S., Nakazato, M., Nass, R., Perez-Tilve, D., Pfluger, P.T., Schwartz, T.W., Seeley, R.J., Sleeman, M., Sun, Y., Sussel, L., Tong, J., Thorner, M.O., van der Lely, A.J., van der Ploeg, L.H.T., Zigman, J.M., Kojima, M., Kangawa, K., Smith, R.G., Horvath, T., and Tschöp, M.H.
Published: 2015
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2. Genomewide meta-analysis identifies loci associated with IGF-I and IGEBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016)

Author: Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S.I., Bidlingmaier, M., Broer, L., Cappola, A., Ceda, G.P., Chanock, S., Chen, M.H., Chen, T.C., Chen, Y.D.I., Chung, J., Miglianico, F.D.G., Eriksson, J., Ferrucci, L., Friedrich, N., Gnewuch, C., Goodarzi, M.O., Grarup, N., Guo, T., Hammer, E., Hayes, R.B., Hicks, A.A., Hofman, A., Houwing-Duistermaat, J.J., Hu, F., Hunter, D.J., Husemoen, L.L., Isaacs, A., Jacobs, K.B., Janssen, J.A.M.J.L., Jansson, J.O., Jehmlich, N., Johnson, S., Juul, A., Karlsson, M., Kilpelainen, T.O., Kovacs, P., Kraft, P., Li, C., Linneberg, A., Liu, Y., Loos, R.J.F., Lorentzon, M., Lu, Y., Maggio, M., Magi, R., Meigs, J., Mellstrom, D., Nauck, M., Newman, A.B., Pollak, M.N., Pramstaller, P.P., Prokopenko, I., Psaty, B.M., Reincke, M., Rimm, E.B., Rotter, J.I., Pierre, A.S., Schurmann, C., Seshadri, S., Sjogren, K., Slagboom, P.E., Strickler, H.D., Stumvoll, M., Suh, Y., Sun, Q., Zhang, C., Svensson, J., Tanaka, T., Tare, A., Tonjes, A., Uh, H.W., Duijn, C.M. van, Heemst, D. van, Vandenput, L., Vasan, R.S., Volker, U., Willems, S.M., Ohlsson, C., Wallaschofski, H., Kaplan, R.C., CHARGE Longevity Working Grp, and Body Composition Genetics Consorti
Published: 2017

3. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Author: Zillikens, M.C., Demissie, S., Hsu, Y.H., Yerges-Armstrong, L.M., Chou, W.C., Stolk, L., Livshits, G., Broer, L., Johnson, T., Koller, D.L., Kutalik, Z., Luan, J., Malkin, I., Ried, J.S., Smith, A.V., Thorleifsson, G., Vandenput, L., Hua Zhao, J., Zhang, W., Aghdassi, A., Åkesson, K., Amin, N., Baier, L.J., Barroso, I., Bennett, D.A., Bertram, L., Biffar, R., Bochud, M., Boehnke, M., Borecki, I.B., Buchman, A.S., Byberg, L., Campbell, H., Campos Obanda, N., Cauley, J.A., Cawthon, P.M., Cederberg, H., Chen, Z., Cho, N.H., Jin Choi, H., Claussnitzer, M., Collins, F., Cummings, S.R., De Jager, P.L., Demuth, I., Dhonukshe-Rutten, RAM, Diatchenko, L., Eiriksdottir, G., Enneman, A.W., Erdos, M., Eriksson, J.G., Eriksson, J., Estrada, K., Evans, D.S., Feitosa, M.F., Fu, M., Garcia, M., Gieger, C., Girke, T., Glazer, N.L., Grallert, H., Grewal, J., Han, B.G., Hanson, R.L., Hayward, C., Hofman, A., Hoffman, E.P., Homuth, G., Hsueh, W.C., Hubal, M.J., Hubbard, A., Huffman, K.M., Husted, L.B., Illig, T., Ingelsson, E., Ittermann, T., Jansson, J.O., Jordan, J.M., Jula, A., Karlsson, M., Khaw, K.T., Kilpeläinen, T.O., Klopp, N., Kloth, JSL, Koistinen, H.A., Kraus, W.E., Kritchevsky, S., Kuulasmaa, T., Kuusisto, J., Laakso, M., Lahti, J., Lang, T., Langdahl, B.L., Launer, L.J., Lee, J.Y., Lerch, M.M., Lewis, J.R., Lind, L., Lindgren, C., Liu, Y., Liu, T., Ljunggren, Ö., Lorentzon, M., Luben, R.N., Maixner, W., McGuigan, F.E., Medina-Gomez, C., Meitinger, T., Melhus, H., Mellström, D., Melov, S., Michaëlsson, K., Mitchell, B.D., Morris, A.P., Mosekilde, L., Newman, A., Nielson, C.M., O'Connell, J.R., Oostra, B.A., Orwoll, E.S., Palotie, A., Parker, S., Peacock, M., Perola, M., Peters, A., Polasek, O., Prince, R.L., Räikkönen, K., Ralston, S.H., Ripatti, S., Robbins, J.A., Rotter, J.I., Rudan, I., Salomaa, V., Satterfield, S., Schadt, E.E., Schipf, S., Scott, L., Sehmi, J., Shen, J., Soo Shin, C., Sigurdsson, G., Smith, S., Soranzo, N., Stančáková, A., Steinhagen-Thiessen, E., Streeten, E.A., Styrkarsdottir, U., Swart, KMA, Tan, S.T., Tarnopolsky, M.A., Thompson, P., Thomson, C.A., Thorsteinsdottir, U., Tikkanen, E., Tranah, G.J., Tuomilehto, J., van Schoor, N.M., Verma, A., Vollenweider, P., Völzke, H., Wactawski-Wende, J., Walker, M., Weedon, M.N., Welch, R., Wichmann, H.E., Widen, E., Williams, FMK, Wilson, J.F., Wright, N.C., Xie, W., Yu, L., Zhou, Y., Chambers, J.C., Döring, A., van Duijn, C.M., Econs, M.J., Gudnason, V., Kooner, J.S., Psaty, B.M., Spector, T.D., Stefansson, K., Rivadeneira, F., Uitterlinden, A.G., Wareham, N.J., Ossowski, V., Waterworth, D., Loos, RJF, Karasik, D., Harris, T.B., Ohlsson, C., Kiel, D.P., Zillikens, M.C., Demissie, S., Hsu, Y.H., Yerges-Armstrong, L.M., Chou, W.C., Stolk, L., Livshits, G., Broer, L., Johnson, T., Koller, D.L., Kutalik, Z., Luan, J., Malkin, I., Ried, J.S., Smith, A.V., Thorleifsson, G., Vandenput, L., Hua Zhao, J., Zhang, W., Aghdassi, A., Åkesson, K., Amin, N., Baier, L.J., Barroso, I., Bennett, D.A., Bertram, L., Biffar, R., Bochud, M., Boehnke, M., Borecki, I.B., Buchman, A.S., Byberg, L., Campbell, H., Campos Obanda, N., Cauley, J.A., Cawthon, P.M., Cederberg, H., Chen, Z., Cho, N.H., Jin Choi, H., Claussnitzer, M., Collins, F., Cummings, S.R., De Jager, P.L., Demuth, I., Dhonukshe-Rutten, RAM, Diatchenko, L., Eiriksdottir, G., Enneman, A.W., Erdos, M., Eriksson, J.G., Eriksson, J., Estrada, K., Evans, D.S., Feitosa, M.F., Fu, M., Garcia, M., Gieger, C., Girke, T., Glazer, N.L., Grallert, H., Grewal, J., Han, B.G., Hanson, R.L., Hayward, C., Hofman, A., Hoffman, E.P., Homuth, G., Hsueh, W.C., Hubal, M.J., Hubbard, A., Huffman, K.M., Husted, L.B., Illig, T., Ingelsson, E., Ittermann, T., Jansson, J.O., Jordan, J.M., Jula, A., Karlsson, M., Khaw, K.T., Kilpeläinen, T.O., Klopp, N., Kloth, JSL, Koistinen, H.A., Kraus, W.E., Kritchevsky, S., Kuulasmaa, T., Kuusisto, J., Laakso, M., Lahti, J., Lang, T., Langdahl, B.L., Launer, L.J., Lee, J.Y., Lerch, M.M., Lewis, J.R., Lind, L., Lindgren, C., Liu, Y., Liu, T., Ljunggren, Ö., Lorentzon, M., Luben, R.N., Maixner, W., McGuigan, F.E., Medina-Gomez, C., Meitinger, T., Melhus, H., Mellström, D., Melov, S., Michaëlsson, K., Mitchell, B.D., Morris, A.P., Mosekilde, L., Newman, A., Nielson, C.M., O'Connell, J.R., Oostra, B.A., Orwoll, E.S., Palotie, A., Parker, S., Peacock, M., Perola, M., Peters, A., Polasek, O., Prince, R.L., Räikkönen, K., Ralston, S.H., Ripatti, S., Robbins, J.A., Rotter, J.I., Rudan, I., Salomaa, V., Satterfield, S., Schadt, E.E., Schipf, S., Scott, L., Sehmi, J., Shen, J., Soo Shin, C., Sigurdsson, G., Smith, S., Soranzo, N., Stančáková, A., Steinhagen-Thiessen, E., Streeten, E.A., Styrkarsdottir, U., Swart, KMA, Tan, S.T., Tarnopolsky, M.A., Thompson, P., Thomson, C.A., Thorsteinsdottir, U., Tikkanen, E., Tranah, G.J., Tuomilehto, J., van Schoor, N.M., Verma, A., Vollenweider, P., Völzke, H., Wactawski-Wende, J., Walker, M., Weedon, M.N., Welch, R., Wichmann, H.E., Widen, E., Williams, FMK, Wilson, J.F., Wright, N.C., Xie, W., Yu, L., Zhou, Y., Chambers, J.C., Döring, A., van Duijn, C.M., Econs, M.J., Gudnason, V., Kooner, J.S., Psaty, B.M., Spector, T.D., Stefansson, K., Rivadeneira, F., Uitterlinden, A.G., Wareham, N.J., Ossowski, V., Waterworth, D., Loos, RJF, Karasik, D., Harris, T.B., Ohlsson, C., and Kiel, D.P.
Abstract: Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10(-8)) or suggestively genome wide (p < 2.3 × 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.
Published: 2017

4. Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

Author: Graff, M., Scott, R.A., Justice, A.E., Young, K.L., Feitosa, M.F., Barata, L., Winkler, T.W., Chu, A.Y., Mahajan, A., Hadley, D., Xue, L., Workalemahu, T., Heard-Costa, N.L., den Hoed, M., Ahluwalia, T.S., Qi, Q., Ngwa, J.S., Renström, F., Quaye, L., Eicher, J.D., Hayes, J.E., Cornelis, M., Kutalik, Z., Lim, E., Luan, J., Huffman, J.E., Zhang, W., Zhao, W., Griffin, P.J., Haller, T., Ahmad, S., Marques-Vidal, P.M., Bien, S., Yengo, L., Teumer, A., Smith, A.V., Kumari, M., Harder, M.N., Justesen, J.M., Kleber, M.E., Hollensted, M., Lohman, K., Rivera, N.V., Whitfield, J.B., Zhao, J.H., Stringham, H.M., Lyytikäinen, L.P., Huppertz, C., Willemsen, G., Peyrot, W.J., Wu, Y., Kristiansson, K., Demirkan, A., Fornage, M., Hassinen, M., Bielak, L.F., Cadby, G., Tanaka, T., Mägi, R., van der Most, P.J., Jackson, A.U., Bragg-Gresham, J.L., Vitart, V., Marten, J., Navarro, P., Bellis, C., Pasko, D., Johansson, Å., Snitker, S., Cheng, Y.C., Eriksson, J., Lim, U., Aadahl, M., Adair, L.S., Amin, N., Balkau, B., Auvinen, J., Beilby, J., Bergman, R.N., Bergmann, S., Bertoni, A.G., Blangero, J., Bonnefond, A., Bonnycastle, L.L., Borja, J.B., Brage, S., Busonero, F., Buyske, S., Campbell, H., Chines, P.S., Collins, F.S., Corre, T., Smith, G.D., Delgado, G.E., Dueker, N., Dörr, M., Ebeling, T., Eiriksdottir, G., Esko, T., Faul, J.D., Fu, M., Færch, K., Gieger, C., Gläser, S., Gong, J., Gordon-Larsen, P., Grallert, H., Grammer, T.B., Grarup, N., van Grootheest, G., Harald, K., Hastie, N.D., Havulinna, A.S., Hernandez, D., Hindorff, L., Hocking, L.J., Holmens, O.L., Holzapfel, C., Hottenga, J.J., Huang, J., Huang, T., Hui, J., Huth, C., Hutri-Kähönen, N., James, A.L., Jansson, J.O., Jhun, M.A., Juonala, M., Kinnunen, L., Koistinen, H.A., Kolcic, I., Komulainen, P., Kuusisto, J., Kvaløy, K., Kähönen, M., Lakka, T.A., Launer, L.J., Lehne, B., Lindgren, C.M., Lorentzon, M., Luben, R., Marre, M., Milaneschi, Y., Monda, K.L., Montgomery, G.W., De Moor, MHM, Mulas, A., Müller-Nurasyid, M., Musk, A.W., Männikkö, R., Männistö, S., Narisu, N., Nauck, M., Nettleton, J.A., Nolte, I.M., Oldehinkel, A.J., Olden, M., Ong, K.K., Padmanabhan, S., Paternoster, L., Perez, J., Perola, M., Peters, A., Peters, U., Peyser, P.A., Prokopenko, I., Puolijoki, H., Raitakari, O.T., Rankinen, T., Rasmussen-Torvik, L.J., Rawal, R., Ridker, P.M., Rose, L.M., Rudan, I., Sarti, C., Sarzynski, M.A., Savonen, K., Scott, W.R., Sanna, S., Shuldiner, A.R., Sidney, S., Silbernagel, G., Smith, B.H., Smith, J.A., Snieder, H., Stančáková, A., Sternfeld, B., Swift, A.J., Tammelin, T., Tan, S.T., Thorand, B., Thuillier, D., Vandenput, L., Vestergaard, H., van Vliet-Ostaptchouk, J.V., Vohl, M.C., Völker, U., Waeber, G., Walker, M., Wild, S., Wong, A., Wright, A.F., Zillikens, M.C., Zubair, N., Haiman, C.A., Lemarchand, L., Gyllensten, U., Ohlsson, C., Hofman, A., Rivadeneira, F., Uitterlinden, A.G., Pérusse, L., Wilson, J.F., Hayward, C., Polasek, O., Cucca, F., Hveem, K., Hartman, C.A., Tönjes, A., Bandinelli, S., Palmer, L.J., Kardia, SLR, Rauramaa, R., Sørensen, TIA, Tuomilehto, J., Salomaa, V., Penninx, BWJH, de Geus, EJC, Boomsma, D.I., Lehtimäki, T., Mangino, M., Laakso, M., Bouchard, C., Martin, N.G., Kuh, D., Liu, Y., Linneberg, A., März, W., Strauch, K., Kivimäki, M., Harris, T.B., Gudnason, V., Völzke, H., Qi, L., Järvelin, M.R., Chambers, J.C., Kooner, J.S., Froguel, P., Kooperberg, C., Vollenweider, P., Hallmans, G., Hansen, T., Pedersen, O., Metspalu, A., Wareham, N.J., Langenberg, C., Weir, D.R., Porteous, D.J., Boerwinkle, E., Chasman, D.I., CHARGE, Consortium, EPIC-InterAct, Consortium, PAGE, Consortium, Abecasis, G.R., Barroso, I., McCarthy, M.I., Frayling, T.M., O'Connell, J.R., van Duijn, C.M., Boehnke, M., Heid, I.M., Mohlke, K.L., Strachan, D.P., Fox, C.S., Liu, C.T., Hirschhorn, J.N., Klein, R.J., Johnson, A.D., Borecki, I.B., Franks, P.W., North, K.E., Cupples, L.A., Loos, RJF, Kilpeläinen, T.O., Graff, M., Scott, R.A., Justice, A.E., Young, K.L., Feitosa, M.F., Barata, L., Winkler, T.W., Chu, A.Y., Mahajan, A., Hadley, D., Xue, L., Workalemahu, T., Heard-Costa, N.L., den Hoed, M., Ahluwalia, T.S., Qi, Q., Ngwa, J.S., Renström, F., Quaye, L., Eicher, J.D., Hayes, J.E., Cornelis, M., Kutalik, Z., Lim, E., Luan, J., Huffman, J.E., Zhang, W., Zhao, W., Griffin, P.J., Haller, T., Ahmad, S., Marques-Vidal, P.M., Bien, S., Yengo, L., Teumer, A., Smith, A.V., Kumari, M., Harder, M.N., Justesen, J.M., Kleber, M.E., Hollensted, M., Lohman, K., Rivera, N.V., Whitfield, J.B., Zhao, J.H., Stringham, H.M., Lyytikäinen, L.P., Huppertz, C., Willemsen, G., Peyrot, W.J., Wu, Y., Kristiansson, K., Demirkan, A., Fornage, M., Hassinen, M., Bielak, L.F., Cadby, G., Tanaka, T., Mägi, R., van der Most, P.J., Jackson, A.U., Bragg-Gresham, J.L., Vitart, V., Marten, J., Navarro, P., Bellis, C., Pasko, D., Johansson, Å., Snitker, S., Cheng, Y.C., Eriksson, J., Lim, U., Aadahl, M., Adair, L.S., Amin, N., Balkau, B., Auvinen, J., Beilby, J., Bergman, R.N., Bergmann, S., Bertoni, A.G., Blangero, J., Bonnefond, A., Bonnycastle, L.L., Borja, J.B., Brage, S., Busonero, F., Buyske, S., Campbell, H., Chines, P.S., Collins, F.S., Corre, T., Smith, G.D., Delgado, G.E., Dueker, N., Dörr, M., Ebeling, T., Eiriksdottir, G., Esko, T., Faul, J.D., Fu, M., Færch, K., Gieger, C., Gläser, S., Gong, J., Gordon-Larsen, P., Grallert, H., Grammer, T.B., Grarup, N., van Grootheest, G., Harald, K., Hastie, N.D., Havulinna, A.S., Hernandez, D., Hindorff, L., Hocking, L.J., Holmens, O.L., Holzapfel, C., Hottenga, J.J., Huang, J., Huang, T., Hui, J., Huth, C., Hutri-Kähönen, N., James, A.L., Jansson, J.O., Jhun, M.A., Juonala, M., Kinnunen, L., Koistinen, H.A., Kolcic, I., Komulainen, P., Kuusisto, J., Kvaløy, K., Kähönen, M., Lakka, T.A., Launer, L.J., Lehne, B., Lindgren, C.M., Lorentzon, M., Luben, R., Marre, M., Milaneschi, Y., Monda, K.L., Montgomery, G.W., De Moor, MHM, Mulas, A., Müller-Nurasyid, M., Musk, A.W., Männikkö, R., Männistö, S., Narisu, N., Nauck, M., Nettleton, J.A., Nolte, I.M., Oldehinkel, A.J., Olden, M., Ong, K.K., Padmanabhan, S., Paternoster, L., Perez, J., Perola, M., Peters, A., Peters, U., Peyser, P.A., Prokopenko, I., Puolijoki, H., Raitakari, O.T., Rankinen, T., Rasmussen-Torvik, L.J., Rawal, R., Ridker, P.M., Rose, L.M., Rudan, I., Sarti, C., Sarzynski, M.A., Savonen, K., Scott, W.R., Sanna, S., Shuldiner, A.R., Sidney, S., Silbernagel, G., Smith, B.H., Smith, J.A., Snieder, H., Stančáková, A., Sternfeld, B., Swift, A.J., Tammelin, T., Tan, S.T., Thorand, B., Thuillier, D., Vandenput, L., Vestergaard, H., van Vliet-Ostaptchouk, J.V., Vohl, M.C., Völker, U., Waeber, G., Walker, M., Wild, S., Wong, A., Wright, A.F., Zillikens, M.C., Zubair, N., Haiman, C.A., Lemarchand, L., Gyllensten, U., Ohlsson, C., Hofman, A., Rivadeneira, F., Uitterlinden, A.G., Pérusse, L., Wilson, J.F., Hayward, C., Polasek, O., Cucca, F., Hveem, K., Hartman, C.A., Tönjes, A., Bandinelli, S., Palmer, L.J., Kardia, SLR, Rauramaa, R., Sørensen, TIA, Tuomilehto, J., Salomaa, V., Penninx, BWJH, de Geus, EJC, Boomsma, D.I., Lehtimäki, T., Mangino, M., Laakso, M., Bouchard, C., Martin, N.G., Kuh, D., Liu, Y., Linneberg, A., März, W., Strauch, K., Kivimäki, M., Harris, T.B., Gudnason, V., Völzke, H., Qi, L., Järvelin, M.R., Chambers, J.C., Kooner, J.S., Froguel, P., Kooperberg, C., Vollenweider, P., Hallmans, G., Hansen, T., Pedersen, O., Metspalu, A., Wareham, N.J., Langenberg, C., Weir, D.R., Porteous, D.J., Boerwinkle, E., Chasman, D.I., CHARGE, Consortium, EPIC-InterAct, Consortium, PAGE, Consortium, Abecasis, G.R., Barroso, I., McCarthy, M.I., Frayling, T.M., O'Connell, J.R., van Duijn, C.M., Boehnke, M., Heid, I.M., Mohlke, K.L., Strachan, D.P., Fox, C.S., Liu, C.T., Hirschhorn, J.N., Klein, R.J., Johnson, A.D., Borecki, I.B., Franks, P.W., North, K.E., Cupples, L.A., Loos, RJF, and Kilpeläinen, T.O.
Abstract: [This corrects the article DOI: 10.1371/journal.pgen.1006528.].
Published: 2017

5. A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in s

Author: Coviello, A.D. (Andrea), Haring, R. (Robin), Wellons, M. (Melissa), Vaidya, D. (Dhananjay), Lehtimäki, T. (Terho), Keildson, S. (Sarah), Lunetta, K.L. (Kathryn), He, C. (Chunyan), Fornage, M. (Myriam), Lagou, V. (Vasiliki), Mangino, M. (Massimo), Onland-Moret, N.C. (Charlotte), Chen, B.H. (Brian), Eriksson, J. (Joel), Garcia, M. (Melissa), Liu, Y. (YongMei), Koster, A. (Annemarie), Lohman, K. (Kurt), Lyytikäinen, L.-P. (Leo-Pekka), Petersen, A.K., Prescott, C.A.J., Stolk, L. (Lisette), Vandenput, L. (Liesbeth), Wood, A.R. (Andrew), Zhuang, W.V., Ruokonen, A. (Aimo), Hartikainen, A.L., Pouta, A. (Anneli), Bandinelli, S. (Stefania), Biffar, R. (Reiner), Brabant, G. (Georg), Cox, D.G. (David), Cummings, S., Ferrucci, L. (Luigi), Gunter, M.J. (Marc J.), Hankinson, S.E. (Susan), Martikainen, H. (Hannu), Hofman, A. (Albert), Homuth, G. (Georg), Illig, T. (Thomas), Jansson, J.O., Johnson, A.D. (Andrew), Karasik, D. (David), Karlsson, M. (Magnus), Kettunen, J. (Johannes), Kiel, D.P. (Douglas), Kraft, P. (Peter), Ljunggren, O. (Östen), Lorentzon, M. (Mattias), Maggio, M. (Marcello), Markus, M.R.P. (Marcello R. P.), Mellström, D. (Dan), Miljkovic, I. (Iva), Mirel, D. (Daniel), Nelson, S. (Sarah), Morin Papunen, L. (Laure), Peeters, P.H.M., Prokopenko, I. (Inga), Raffel, L.J. (Leslie), Reincke, M. (Martin), Reiner, A.P. (Alex), Rexrode, K. (Kathryn), Rivadeneira Ramirez, F. (Fernando), Schwartz, S.M. (Stephen), Siscovick, D.S. (David), Soranzo, N. (Nicole), Stöckl, D. (Doris), Tworoger, S. (Shelley), Uitterlinden, A.G. (André), Gils, C.H. (Carla) van, Vasan, R.S. (Ramachandran Srini), Wichmann, H.E. (Erich), Zhai, G. (Guangju), Bhasin, S. (Shalender), Bidlingmaier, M. (Martin), Chanock, S.J. (Stephen), Vivo, I. (Immaculata) de, Harris, T.B. (Tamara), Hunter, D. (David), Kähönen, M. (Mika), Ouyang, P. (Pamela), Spector, T.D. (Timothy), Schouw, Y.T. (Yvonne) van der, Viikari, J. (Jorma), Wallaschofski, H. (Henri), McCarthy, M.I. (Mark), Frayling, T.M. (Timothy), Murray, J.C. (Jeffrey), Franks, S. (Steve), Jarvelin, M.-R. (Marjo-Riitta), Jong, F.A. (Floris) de, Raitakari, O. (Olli), Teumer, A. (Alexander), Ohlsson, C. (Claes), Murabito, J. (Joanne), Perry, J.R.B. (John), Coviello, A.D. (Andrea), Haring, R. (Robin), Wellons, M. (Melissa), Vaidya, D. (Dhananjay), Lehtimäki, T. (Terho), Keildson, S. (Sarah), Lunetta, K.L. (Kathryn), He, C. (Chunyan), Fornage, M. (Myriam), Lagou, V. (Vasiliki), Mangino, M. (Massimo), Onland-Moret, N.C. (Charlotte), Chen, B.H. (Brian), Eriksson, J. (Joel), Garcia, M. (Melissa), Liu, Y. (YongMei), Koster, A. (Annemarie), Lohman, K. (Kurt), Lyytikäinen, L.-P. (Leo-Pekka), Petersen, A.K., Prescott, C.A.J., Stolk, L. (Lisette), Vandenput, L. (Liesbeth), Wood, A.R. (Andrew), Zhuang, W.V., Ruokonen, A. (Aimo), Hartikainen, A.L., Pouta, A. (Anneli), Bandinelli, S. (Stefania), Biffar, R. (Reiner), Brabant, G. (Georg), Cox, D.G. (David), Cummings, S., Ferrucci, L. (Luigi), Gunter, M.J. (Marc J.), Hankinson, S.E. (Susan), Martikainen, H. (Hannu), Hofman, A. (Albert), Homuth, G. (Georg), Illig, T. (Thomas), Jansson, J.O., Johnson, A.D. (Andrew), Karasik, D. (David), Karlsson, M. (Magnus), Kettunen, J. (Johannes), Kiel, D.P. (Douglas), Kraft, P. (Peter), Ljunggren, O. (Östen), Lorentzon, M. (Mattias), Maggio, M. (Marcello), Markus, M.R.P. (Marcello R. P.), Mellström, D. (Dan), Miljkovic, I. (Iva), Mirel, D. (Daniel), Nelson, S. (Sarah), Morin Papunen, L. (Laure), Peeters, P.H.M., Prokopenko, I. (Inga), Raffel, L.J. (Leslie), Reincke, M. (Martin), Reiner, A.P. (Alex), Rexrode, K. (Kathryn), Rivadeneira Ramirez, F. (Fernando), Schwartz, S.M. (Stephen), Siscovick, D.S. (David), Soranzo, N. (Nicole), Stöckl, D. (Doris), Tworoger, S. (Shelley), Uitterlinden, A.G. (André), Gils, C.H. (Carla) van, Vasan, R.S. (Ramachandran Srini), Wichmann, H.E. (Erich), Zhai, G. (Guangju), Bhasin, S. (Shalender), Bidlingmaier, M. (Martin), Chanock, S.J. (Stephen), Vivo, I. (Immaculata) de, Harris, T.B. (Tamara), Hunter, D. (David), Kähönen, M. (Mika), Ouyang, P. (Pamela), Spector, T.D. (Timothy), Schouw, Y.T. (Yvonne) van der, Viikari, J. (Jorma), Wallaschofski, H. (Henri), McCarthy, M.I. (Mark), Frayling, T.M. (Timothy), Murray, J.C. (Jeffrey), Franks, S. (Steve), Jarvelin, M.-R. (Marjo-Riitta), Jong, F.A. (Floris) de, Raitakari, O. (Olli), Teumer, A. (Alexander), Ohlsson, C. (Claes), Murabito, J. (Joanne), and Perry, J.R.B. (John)
Abstract: Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 individuals from 10 epidemiologic studies and validated these findings in 7,046 individuals in an additional six studies. We identified twelve genomic regions (SNPs) associated with circulating SHBG concentrations. Loci near the identified SNPs included SHBG, PRMT6, GCKR, ZBTB10, JMJD1C, SLCO1B1, NR2F2, ZNF652, TDGF3, LHCGR, BAIAP2L1, and UGT2B15. These genes encompass multiple biologic pathways, including hepatic function, lipid metabolism, carbohydrate metabolism and T2D, androgen and estrogen receptor function, epigenetic effects, and the biology of sex steroid hormone-responsive cancers including breast and prostate cancer. We found evidence of sex-differentiated genetic influences on SHBG. In a sex-specific GWAS, the loci 4q13.2-UGT2B15 was significant in men only. Additionally, three loci showed strong sex-differentiated effects: 17p13.1-SHBG and Xq22.3-TDGF3 were stronger in men, whereas 8q21.12-ZBTB10 was stronger in women. Conditional analyses identified additional signals at the SHBG gene that together almost double the proportion of variance explained at the locus. Using an independent study of 1,129 individuals, all SNPs identified in the overall or sex-differentiated or conditional analyses explained ~15.6% and ~8.4% of the genetic variation of SHBG concentrations in men and women, respectively. The evidence for sex-differentiated effects and allelic heterogeneity highlight the importance of considering these features when estimating complex trait variance.
Published: 2012
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6. Genetic determinants of serum testosterone concentrations in men

Author: Ohlsson, C. (Claes), Wallaschofski, H. (Henri), Lunetta, K.L. (Kathryn), Stolk, L. (Lisette), Perry, J.R.B. (John), Koster, A. (Annemarie), Petersen, A.K., Eriksson, J. (Joel), Lehtimäki, T. (Terho), Huhtaniemi, I.T. (Ilpo), Hammond, G.L. (Geoffrey), Maggio, M. (Marcello), Coviello, A.D. (Andrea), Ferrucci, L. (Luigi), Heier, M. (Margit), Hofman, A. (Albert), Holliday, K.L. (Kate), Jansson, J.O., Kähönen, M. (Mika), Karasik, D. (David), Karlsson, M.K. (Magnus), Kiel, D.P. (Douglas), Liu, Y. (YongMei), Ljunggren, Ö., Lorentzon, M. (Mattias), Lyytikäinen, L.-P. (Leo-Pekka), Meitinger, T. (Thomas), Mellström, D. (Dan), Melzer, D. (David), Miljkovic, I. (Iva), Nauck, M. (Matthias), Nilsson, M. (Maria), Penninx, B.W.J.H. (Brenda), Pye, S.R. (Stephen), Vasan, R.S. (Ramachandran Srini), Reincke, M. (Martin), Rivadeneira Ramirez, F. (Fernando), Tajar, A. (Abdelouahid), Teumer, A. (Alexander), Uitterlinden, A.G. (André), Ulloor, J. (Jagadish), Viikari, J. (Jorma), Völker, U. (Uwe), Völzke, H. (Henry), Wichmann, H.E. (Heinz Erich), Wu, T.-S., Zhuang, W.V., Ziv, E. (Elad), Raitakari, O. (Olli), Bidlingmaier, M. (Martin), Harris, T.B. (Tamara), Murray, A. (Anna), Jong, F.H. (Frank) de, Murabito, J. (Joanne), Bhasin, S. (Shalender), Vandenput, L. (Liesbeth), Haring, R. (Robin), Ohlsson, C. (Claes), Wallaschofski, H. (Henri), Lunetta, K.L. (Kathryn), Stolk, L. (Lisette), Perry, J.R.B. (John), Koster, A. (Annemarie), Petersen, A.K., Eriksson, J. (Joel), Lehtimäki, T. (Terho), Huhtaniemi, I.T. (Ilpo), Hammond, G.L. (Geoffrey), Maggio, M. (Marcello), Coviello, A.D. (Andrea), Ferrucci, L. (Luigi), Heier, M. (Margit), Hofman, A. (Albert), Holliday, K.L. (Kate), Jansson, J.O., Kähönen, M. (Mika), Karasik, D. (David), Karlsson, M.K. (Magnus), Kiel, D.P. (Douglas), Liu, Y. (YongMei), Ljunggren, Ö., Lorentzon, M. (Mattias), Lyytikäinen, L.-P. (Leo-Pekka), Meitinger, T. (Thomas), Mellström, D. (Dan), Melzer, D. (David), Miljkovic, I. (Iva), Nauck, M. (Matthias), Nilsson, M. (Maria), Penninx, B.W.J.H. (Brenda), Pye, S.R. (Stephen), Vasan, R.S. (Ramachandran Srini), Reincke, M. (Martin), Rivadeneira Ramirez, F. (Fernando), Tajar, A. (Abdelouahid), Teumer, A. (Alexander), Uitterlinden, A.G. (André), Ulloor, J. (Jagadish), Viikari, J. (Jorma), Völker, U. (Uwe), Völzke, H. (Henry), Wichmann, H.E. (Heinz Erich), Wu, T.-S., Zhuang, W.V., Ziv, E. (Elad), Raitakari, O. (Olli), Bidlingmaier, M. (Martin), Harris, T.B. (Tamara), Murray, A. (Anna), Jong, F.H. (Frank) de, Murabito, J. (Joanne), Bhasin, S. (Shalender), Vandenput, L. (Liesbeth), and Haring, R. (Robin)
Abstract: Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as <300 ng/dl. Two single-nucleotide polymorphisms at the sex hormone-binding globulin (SHBG) locus (17p13-p12) were identified as independently associated with serum testosterone concentration (rs12150660, p = 1.2×10-41and rs6258, p = 2.3×10-22). Subjects with ≥3 risk alleles of these variants had 6.5-fold higher risk of having low serum testosterone than subjects with no risk allele. The rs5934505 polymorphism near FAM9B on the X chromosome was also associated with testosterone concentrations (p = 5.6×10-16). The rs6258 polymorphism in exon 4 of SHBG affected SHBG's affinity for binding testosterone and the measured free testosterone fraction (p<0.01). Genetic variants in the SHBG locus and on the X chromosome are associated with a substantial variation in testosterone concentrations and increased risk of low testosterone. rs6258 is the first reported SHBG polymorphism, which affects testosterone binding to SHBG and the free testosterone fraction and could therefore influence the calculation of free testosterone using law-of-mass-action equation.
Published: 2011
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7. Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children

Author: Kilpeläinen, T.O. (Tuomas), Qi, L. (Lu), Brage, S. (Soren), Sharp, S.J. (Stephen), Sonestedt, E. (Emily), Demerath, E.W. (Ellen), Ahmad, T. (Tariq), Mora, S. (Samia), Kaakinen, M. (Marika), Sandholt, C. (Camilla), Holzapfel, C. (Christina), Autenrieth, C.S. (Christine), Hyppönen, E. (Elina), Cauchi, S. (Stephane), He, M. (Meian), Kutalik, Z. (Zoltán), Kumari, M. (Meena), Stancáková, A. (Alena), Meidtner, K. (Karina), Balkau, B. (Beverley), Tan, J.T. (Jonathan), Mangino, M. (Massimo), Timpson, N.J. (Nicholas), Song, Y. (Yiqing), Zillikens, M.C. (Carola), Jablonski, K.A. (Kathleen), Garcia, M. (Melissa), Johansson, S. (Stefan), Bragg-Gresham, J.L. (Jennifer L.), Wu, Y. (Ying), Vliet-Ostaptchouk, J.V. (Jana) van, Onland-Moret, N.C. (Charlotte), Zimmermann, E. (Esther), Rivera, N.V. (Natalia), Tanaka, T. (Toshiko), Stringham, H.M. (Heather), Silbernagel, G. (Günther), Kanoni, S. (Stavroula), Feitosa, M.F. (Mary Furlan), Snitker, S. (Soren), Ruiz, J.R. (Jonatan), Metter, J. (Jeffery), Larrad, M.T.M., Atalay, M. (Mustafa), Hakanen, M. (Maarit), Amin, N. (Najaf), Cavalcanti-Proença, C. (Christine), Grøntved, A. (Anders), Hallmans, G. (Göran), Jansson, J.O., Kuusisto, J. (Johanna), Kähönen, M. (Mika), Lutsey, P.L. (Pamela), Nolan, J.J. (John), Palla, L. (Luigi), Pedersen, O. (Oluf), Pérusse, L. (Louis), Renström, F. (Frida), Scott, R.A. (Robert), Shungin, D. (Dmitry), Sovio, U. (Ulla), Tammelin, T.H. (Tuija), Rönnemaa, T. (Tapani), Lakka, T.A. (Timo), Uusitupa, M. (Matti), Rios, M.S., Ferrucci, L. (Luigi), Bouchard, C. (Claude), Meirhaeghe, A. (Aline), Fu, M. (Mao), Walker, M. (Mark), Borecki, I.B. (Ingrid), Dedoussis, G.V. (George), Fritsche, A. (Andreas), Ohlsson, C. (Claes), Boehnke, M. (Michael), Bandinelli, S. (Stefania), Tikka-Kleemola, P. (Päivi), Lawlor, D.A. (Debbie), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Sørensen, T.I.A. (Thorkild), Mohlke, K.L. (Karen), Hofman, A. (Albert), Uitterlinden, A.G. (André), Tuomilehto, J. (Jaakko), Lehtimäki, T. (Terho), Raitakari, O. (Olli), Isomaa, B. (Bo), Njolstad, P. (Pal), Florez, J.C. (Jose), Liu, S. (Simin), Ness, A.R. (Andrew), Spector, T.D. (Timothy), Tai, E.S. (Shyong), Froguel, P. (Philippe), Boeing, H. (Heiner), Laakso, M. (Markku), Marmot, M. (Michael), Bergmann, S.M. (Sven), Power, C. (Chris), Khaw, K.-T., Chasman, D.I. (Daniel), Ridker, P.M. (Paul), Hansen, T. (Torben), Monda, K.L. (Keri), Illig, T. (Thomas), Järvelin, M.R., Wareham, N.J. (Nick), Ebrahim, S. (Shanil), Hu, F.B. (Frank), Groop, L. (Leif), Orho-Melander, M. (Marju), Ekelund, U. (Ulf), Franks, P.W. (Paul), Loos, R.J.F. (Ruth), Kilpeläinen, T.O. (Tuomas), Qi, L. (Lu), Brage, S. (Soren), Sharp, S.J. (Stephen), Sonestedt, E. (Emily), Demerath, E.W. (Ellen), Ahmad, T. (Tariq), Mora, S. (Samia), Kaakinen, M. (Marika), Sandholt, C. (Camilla), Holzapfel, C. (Christina), Autenrieth, C.S. (Christine), Hyppönen, E. (Elina), Cauchi, S. (Stephane), He, M. (Meian), Kutalik, Z. (Zoltán), Kumari, M. (Meena), Stancáková, A. (Alena), Meidtner, K. (Karina), Balkau, B. (Beverley), Tan, J.T. (Jonathan), Mangino, M. (Massimo), Timpson, N.J. (Nicholas), Song, Y. (Yiqing), Zillikens, M.C. (Carola), Jablonski, K.A. (Kathleen), Garcia, M. (Melissa), Johansson, S. (Stefan), Bragg-Gresham, J.L. (Jennifer L.), Wu, Y. (Ying), Vliet-Ostaptchouk, J.V. (Jana) van, Onland-Moret, N.C. (Charlotte), Zimmermann, E. (Esther), Rivera, N.V. (Natalia), Tanaka, T. (Toshiko), Stringham, H.M. (Heather), Silbernagel, G. (Günther), Kanoni, S. (Stavroula), Feitosa, M.F. (Mary Furlan), Snitker, S. (Soren), Ruiz, J.R. (Jonatan), Metter, J. (Jeffery), Larrad, M.T.M., Atalay, M. (Mustafa), Hakanen, M. (Maarit), Amin, N. (Najaf), Cavalcanti-Proença, C. (Christine), Grøntved, A. (Anders), Hallmans, G. (Göran), Jansson, J.O., Kuusisto, J. (Johanna), Kähönen, M. (Mika), Lutsey, P.L. (Pamela), Nolan, J.J. (John), Palla, L. (Luigi), Pedersen, O. (Oluf), Pérusse, L. (Louis), Renström, F. (Frida), Scott, R.A. (Robert), Shungin, D. (Dmitry), Sovio, U. (Ulla), Tammelin, T.H. (Tuija), Rönnemaa, T. (Tapani), Lakka, T.A. (Timo), Uusitupa, M. (Matti), Rios, M.S., Ferrucci, L. (Luigi), Bouchard, C. (Claude), Meirhaeghe, A. (Aline), Fu, M. (Mao), Walker, M. (Mark), Borecki, I.B. (Ingrid), Dedoussis, G.V. (George), Fritsche, A. (Andreas), Ohlsson, C. (Claes), Boehnke, M. (Michael), Bandinelli, S. (Stefania), Tikka-Kleemola, P. (Päivi), Lawlor, D.A. (Debbie), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Sørensen, T.I.A. (Thorkild), Mohlke, K.L. (Karen), Hofman, A. (Albert), Uitterlinden, A.G. (André), Tuomilehto, J. (Jaakko), Lehtimäki, T. (Terho), Raitakari, O. (Olli), Isomaa, B. (Bo), Njolstad, P. (Pal), Florez, J.C. (Jose), Liu, S. (Simin), Ness, A.R. (Andrew), Spector, T.D. (Timothy), Tai, E.S. (Shyong), Froguel, P. (Philippe), Boeing, H. (Heiner), Laakso, M. (Markku), Marmot, M. (Michael), Bergmann, S.M. (Sven), Power, C. (Chris), Khaw, K.-T., Chasman, D.I. (Daniel), Ridker, P.M. (Paul), Hansen, T. (Torben), Monda, K.L. (Keri), Illig, T. (Thomas), Järvelin, M.R., Wareham, N.J. (Nick), Ebrahim, S. (Shanil), Hu, F.B. (Frank), Groop, L. (Leif), Orho-Melander, M. (Marju), Ekelund, U. (Ulf), Franks, P.W. (Paul), and Loos, R.J.F. (Ruth)
Abstract: Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268). Methods and Findings: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r2>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (pinteraction= 0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio = 1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio = 1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. Conclu
Published: 2011
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8. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Author: Kilpeläinen, T.O. (Tuomas), Zillikens, M.C. (Carola), Stancáková, A. (Alena), Finucane, F.M. (Francis), Ried, J.S. (Janina), Langenberg, C. (Claudia), Zhang, W. (Weihua), Beckmann, J.S. (Jacques), Luan, J., Vandenput, L. (Liesbeth), Styrkarsdottir, U. (Unnur), Zhou, Y. (Yanhua), Smith, A.V. (Albert Vernon), Zhao, J.H. (Jing Hua), Amin, N. (Najaf), Vedantam, S. (Sailaja), Shin, S.-Y., Haritunians, T. (Talin), Fu, M. (Mao), Feitosa, M.F. (Mary Furlan), Kumari, M. (Meena), Halldorsson, B.V. (Bjarni), Tikkanen, E. (Emmi), Mangino, M. (Massimo), Hayward, C. (Caroline), Song, C. (Ci), Arnold, A.M. (Alice), Oostra, B.A. (Ben), Campbell, H. (Harry), Cupples, L.A. (Adrienne), Davis, K.E. (Kathryn), Döring, A. (Angela), Eiriksdottir, G. (Gudny), Estrada Gil, K. (Karol), Fernández-Real, J.M., Garcia, M. (Melissa), Gieger, C. (Christian), Glazer, N.L. (Nicole), Guiducci, C. (Candace), Hofman, A. (Albert), Humphries, S.E. (Steve), Isomaa, B. (Bo), Jacobs, L.C. (Leonie), Jula, A. (Antti), Karasik, D. (David), Karlsson, M.K. (Magnus), Khaw, K-T. (Kay-Tee), Kim, L.J. (Lauren), Kivimaki, M. (Mika), Klopp, N. (Norman), Kuhnel, B. (Brigitte), Kuusisto, J. (Johanna), Liu, Y. (YongMei), Ljunggren, Ö., Lorentzon, M. (Mattias), Luben, R.N. (Robert), McKnight, B. (Barbara), Mellström, D. (Dan), Mitchell, B.D. (Braxton), Mooser, V. (Vincent), Moreno, J.M., Männistö, S. (Satu), O'Connell, J.R. (Jeffery), Pascoe, L. (Laura), Peltonen, L. (Leena Johanna), Peral, B. (Belén), Perola, M. (Markus), Psaty, B.M. (Bruce), Salomaa, V. (Veikko), Savage, D.B. (David), Semple, R.K. (Robert), Skaric-Juric, T. (Tatjana), Sigurdsson, G. (Gunnar), Spector, T.D. (Timothy), Syvänen, A.-C., Talmud, P.J. (Philippa), Thorleifsson, G. (Gudmar), Thorsteinsdottir, U. (Unnur), Uitterlinden, A.G. (André), Tikka-Kleemola, P. (Päivi), Vidal-Puig, A. (Antonio), Wild, S.H. (Sarah), Wright, A.F. (Alan), Clegg, D.J. (Deborah), Schadt, E.E. (Eric), Wilson, J.F. (James), Rudan, I. (Igor), Ripatti, S. (Samuli), Borecki, I.B. (Ingrid), Shuldiner, A.R. (Alan), Ingelsson, E. (Erik), Jansson, J.O., Kaplan, R.C. (Robert), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Groop, L. (Leif), Kiel, D.P. (Douglas), Rivadeneira Ramirez, F. (Fernando), Walker, M. (Mark), Barroso, I.E. (Inês), Vollenweider, P. (Peter), Waeber, G. (Gérard), Chambers, J.C. (John), Kooner, J.S. (Jaspal), Soranzo, N. (Nicole), Hirschhorn, J.N. (Joel), Stefansson, K. (Kari), Wichmann, H.E. (Heinz Erich), Ohlsson, C. (Claes), O'Rahilly, S. (Stephen), Wareham, N.J. (Nick), Speliotes, E.K. (Elizabeth), Fox, C.S. (Caroline), Laakso, M. (Markku), Loos, R.J.F. (Ruth), Aulchenko, Y.S. (Yurii), Kilpeläinen, T.O. (Tuomas), Zillikens, M.C. (Carola), Stancáková, A. (Alena), Finucane, F.M. (Francis), Ried, J.S. (Janina), Langenberg, C. (Claudia), Zhang, W. (Weihua), Beckmann, J.S. (Jacques), Luan, J., Vandenput, L. (Liesbeth), Styrkarsdottir, U. (Unnur), Zhou, Y. (Yanhua), Smith, A.V. (Albert Vernon), Zhao, J.H. (Jing Hua), Amin, N. (Najaf), Vedantam, S. (Sailaja), Shin, S.-Y., Haritunians, T. (Talin), Fu, M. (Mao), Feitosa, M.F. (Mary Furlan), Kumari, M. (Meena), Halldorsson, B.V. (Bjarni), Tikkanen, E. (Emmi), Mangino, M. (Massimo), Hayward, C. (Caroline), Song, C. (Ci), Arnold, A.M. (Alice), Oostra, B.A. (Ben), Campbell, H. (Harry), Cupples, L.A. (Adrienne), Davis, K.E. (Kathryn), Döring, A. (Angela), Eiriksdottir, G. (Gudny), Estrada Gil, K. (Karol), Fernández-Real, J.M., Garcia, M. (Melissa), Gieger, C. (Christian), Glazer, N.L. (Nicole), Guiducci, C. (Candace), Hofman, A. (Albert), Humphries, S.E. (Steve), Isomaa, B. (Bo), Jacobs, L.C. (Leonie), Jula, A. (Antti), Karasik, D. (David), Karlsson, M.K. (Magnus), Khaw, K-T. (Kay-Tee), Kim, L.J. (Lauren), Kivimaki, M. (Mika), Klopp, N. (Norman), Kuhnel, B. (Brigitte), Kuusisto, J. (Johanna), Liu, Y. (YongMei), Ljunggren, Ö., Lorentzon, M. (Mattias), Luben, R.N. (Robert), McKnight, B. (Barbara), Mellström, D. (Dan), Mitchell, B.D. (Braxton), Mooser, V. (Vincent), Moreno, J.M., Männistö, S. (Satu), O'Connell, J.R. (Jeffery), Pascoe, L. (Laura), Peltonen, L. (Leena Johanna), Peral, B. (Belén), Perola, M. (Markus), Psaty, B.M. (Bruce), Salomaa, V. (Veikko), Savage, D.B. (David), Semple, R.K. (Robert), Skaric-Juric, T. (Tatjana), Sigurdsson, G. (Gunnar), Spector, T.D. (Timothy), Syvänen, A.-C., Talmud, P.J. (Philippa), Thorleifsson, G. (Gudmar), Thorsteinsdottir, U. (Unnur), Uitterlinden, A.G. (André), Tikka-Kleemola, P. (Päivi), Vidal-Puig, A. (Antonio), Wild, S.H. (Sarah), Wright, A.F. (Alan), Clegg, D.J. (Deborah), Schadt, E.E. (Eric), Wilson, J.F. (James), Rudan, I. (Igor), Ripatti, S. (Samuli), Borecki, I.B. (Ingrid), Shuldiner, A.R. (Alan), Ingelsson, E. (Erik), Jansson, J.O., Kaplan, R.C. (Robert), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Groop, L. (Leif), Kiel, D.P. (Douglas), Rivadeneira Ramirez, F. (Fernando), Walker, M. (Mark), Barroso, I.E. (Inês), Vollenweider, P. (Peter), Waeber, G. (Gérard), Chambers, J.C. (John), Kooner, J.S. (Jaspal), Soranzo, N. (Nicole), Hirschhorn, J.N. (Joel), Stefansson, K. (Kari), Wichmann, H.E. (Heinz Erich), Ohlsson, C. (Claes), O'Rahilly, S. (Stephen), Wareham, N.J. (Nick), Speliotes, E.K. (Elizabeth), Fox, C.S. (Caroline), Laakso, M. (Markku), Loos, R.J.F. (Ruth), and Aulchenko, Y.S. (Yurii)
Abstract: Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10-6) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10-26) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10-11) and one near SPRY2 (P = 3 × 10-8). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance.
Published: 2011
Full Text: View/download PDF

9. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Author: Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A., Allen, H.L., Lindgren, C.M., Luan, J., Magi, R., Randall, J., Vedantam, S., Winkler, T.W., Qi, L., Workalemahu, T., Heid, I.M., Steinthorsdottir, V., Stringham, H.M., Weedon, M.N., Wheeler, E., Wood, A.R., Ferreira, T., Weyant, R.J., Segre, A., Estrada, K., Liang, L., Nemesh, J., Park, J., Gustafsson, S., Kilpelainen, T.O., Yang, J., Bouatia-Naji, N., Esko, T., Feitosa, M.F., Kutalik, Z., Mangino, M., Raychaudhuri, S., Scherag, A., Smith, A.V., Welch, R., Zhao, J.H., Aben, K.K.H., Absher, D., Amin, N., Dixon, A.L., Fisher, E., Glazer, N.L., Goddard, M.E., Hoesel, V., Hottenga, J.J., Johansson, A, Johnson, T., Ketkar, S., Lamina, C., Li, S., Moffatt, M.F., Myers, R.H., Narisu, N., Perry, J.R., Peters, M.J., Preuss, M., Ripatti, S., Rivadeneira, F., Sandholt, C., Scott, L.J., Timpson, N.J., Tyrer, J.P., Wingerden, S. van, Watanabe, R.M., White, C.C., Wiklund, F., Barlassina, C., Chasman, D.I., Cooper, M., Jansson, J.O., Lawrence, R.W., Pellikka, N., Prokopenko, I., Shi, J., Thiering, E., Alavere, H., Alibrandi, M.T., Almgren, P., Kiemeney, L.A.L.M., Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A., Allen, H.L., Lindgren, C.M., Luan, J., Magi, R., Randall, J., Vedantam, S., Winkler, T.W., Qi, L., Workalemahu, T., Heid, I.M., Steinthorsdottir, V., Stringham, H.M., Weedon, M.N., Wheeler, E., Wood, A.R., Ferreira, T., Weyant, R.J., Segre, A., Estrada, K., Liang, L., Nemesh, J., Park, J., Gustafsson, S., Kilpelainen, T.O., Yang, J., Bouatia-Naji, N., Esko, T., Feitosa, M.F., Kutalik, Z., Mangino, M., Raychaudhuri, S., Scherag, A., Smith, A.V., Welch, R., Zhao, J.H., Aben, K.K.H., Absher, D., Amin, N., Dixon, A.L., Fisher, E., Glazer, N.L., Goddard, M.E., Hoesel, V., Hottenga, J.J., Johansson, A, Johnson, T., Ketkar, S., Lamina, C., Li, S., Moffatt, M.F., Myers, R.H., Narisu, N., Perry, J.R., Peters, M.J., Preuss, M., Ripatti, S., Rivadeneira, F., Sandholt, C., Scott, L.J., Timpson, N.J., Tyrer, J.P., Wingerden, S. van, Watanabe, R.M., White, C.C., Wiklund, F., Barlassina, C., Chasman, D.I., Cooper, M., Jansson, J.O., Lawrence, R.W., Pellikka, N., Prokopenko, I., Shi, J., Thiering, E., Alavere, H., Alibrandi, M.T., Almgren, P., and Kiemeney, L.A.L.M.
Abstract: Contains fulltext : 88350.pdf (publisher's version ) (Closed access)
Published: 2010

10. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Author: Heid, I.M., Jackson, A.U., Randall, J.C., Winkler, T.W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M.C., Speliotes, E.K., Mägi, R., Workalemahu, T., White, C.C., Bouatia-Naji, N., Harris, T.B., Berndt, S.I., Ingelsson, E., Willer, C.J., Weedon, M.N., Luan, J., Vedantam, S., Esko, T., Kilpeläinen, T.O., Kutalik, Z., Li, S., Monda, K.L., Dixon, A.L., Holmes, C.C., Kaplan, L.M., Liang, L., Min, J.L., Moffatt, M.F., Molony, C., Nicholson, G., Schadt, E.E., Zondervan, K.T., Feitosa, M.F., Ferreira, T., Allen, H.L., Weyant, R.J., Wheeler, E., Wood, A.R., MAGIC, Estrada, K., Goddard, M.E., Lettre, G., Mangino, M., Nyholt, D.R., Purcell, S., Smith, A.V., Visscher, P.M., Yang, J., McCarroll, S.A., Nemesh, J., Voight, B.F., Absher, D., Amin, N., Aspelund, T., Coin, L., Glazer, N.L., Hayward, C., Heard-Costa, N.L., Hottenga, J.J., Johansson, A., Johnson, T., Kaakinen, M., Kapur, K., Ketkar, S., Knowles, J.W., Kraft, P., Kraja, A.T., Lamina, C., Leitzmann, M.F., McKnight, B., Morris, A.P., Ong, K.K., Perry, J.R., Peters, M.J., Polasek, O., Prokopenko, I., Rayner, N.W., Ripatti, S., Rivadeneira, F., Robertson, N.R., Sanna, S., Sovio, U., Surakka, I., Teumer, A., van Wingerden, S., Vitart, V., Zhao, J.H., Cavalcanti-Proença, C., Chines, P.S., Fisher, E., Kulzer, J.R., Lecoeur, C., Narisu, N., Sandholt, C., Scott, L.J., Silander, K., Stark, K., Tammesoo, M.L., Teslovich, T.M., Timpson, N.J., Watanabe, R.M., Welch, R., Chasman, D.I., Cooper, M.N., Jansson, J.O., Kettunen, J., Lawrence, R.W., Pellikka, N., Perola, M., Vandenput, L., Alavere, H., Almgren, P., Atwood, L.D., Bennett, A.J., Biffar, R., Bonnycastle, L.L., Bornstein, S.R., Buchanan, T.A., Campbell, H., Day, I.N., Dei, M., Dörr, M., Elliott, P., Erdos, M.R., Eriksson, J.G., Freimer, N.B., Fu, M., Gaget, S., Geus, E.J., Gjesing, A.P., Grallert, H., Grässler, J., Groves, C.J., Guiducci, C., Hartikainen, A.L., Hassanali, N., Havulinna, A.S., Herzig, K.H., Hicks, A.A., Hui, J., Igl, W., Jousilahti, P., Jula, A., Kajantie, E., Kinnunen, L., Kolcic, I., Koskinen, S., Kovacs, P., Kroemer, H.K., Krzelj, V., Kuusisto, J., Kvaloy, K., Laitinen, J., Lantieri, O., Lathrop, G.M., Lokki, M.L., Luben, R.N., Ludwig, B., McArdle, W.L., McCarthy, A., Morken, M.A., Nelis, M., Neville, M.J., Paré, G., Parker, A.N., Peden, J.F., Pichler, I., Pietiläinen, K.H., Platou, C.G., Pouta, A., Ridderstråle, M., Samani, N.J., Saramies, J., Sinisalo, J., Smit, J.H., Strawbridge, R.J., Stringham, H.M., Swift, A.J., Teder-Laving, M., Thomson, B., Usala, G., van Meurs, J.B., van Ommen, G.J., Vatin, V., Volpato, C.B., Wallaschofski, H., Walters, G.B., Widen, E., Wild, S.H., Willemsen, G., Witte, D.R., Zgaga, L., Zitting, P., Beilby, J.P., James, A.L., Kähönen, M., Lehtimäki, T., Nieminen, M.S., Ohlsson, C., Palmer, L.J., Raitakari, O., Ridker, P.M., Stumvoll, M., Tönjes, A., Viikari, J., Balkau, B., Ben-Shlomo, Y., Bergman, R.N., Boeing, H., Smith, G.D., Ebrahim, S., Froguel, P., Hansen, T., Hengstenberg, C., Hveem, K., Isomaa, B., Jørgensen, T., Karpe, F., Khaw, K.T., Laakso, M., Lawlor, D.A., Marre, M., Meitinger, T., Metspalu, A., Midthjell, K., Pedersen, O., Salomaa, V., Schwarz, P.E., Tuomi, T., Tuomilehto, J., Valle, T.T., Wareham, N.J., Arnold, A.M., Beckmann, J.S., Bergmann, S., Boerwinkle, E., Boomsma, D.I., Caulfield, M.J., Collins, F.S., Eiriksdottir, G., Gudnason, V., Gyllensten, U., Hamsten, A., Hattersley, A.T., Hofman, A., Hu, F.B., Illig, T., Iribarren, C., Jarvelin, M.R., Kao, W.H., Kaprio, J., Launer, L.J., Munroe, P.B., Oostra, B., Penninx, B.W., Pramstaller, P.P., Psaty, B.M., Quertermous, T., Rissanen, A., Rudan, I., Shuldiner, A.R., Soranzo, N., Spector, T.D., Syvanen, A.C., Uda, M., Uitterlinden, A., Völzke, H., Vollenweider, P., Wilson, J.F., Witteman, J.C., Wright, A.F., Abecasis, G.R., Boehnke, M., Borecki, I.B., Deloukas, P., Frayling, T.M., Groop, L.C., Haritunians, T., Hunter, D.J., Kaplan, R.C., North, K.E., O'Connell, J.R., Peltonen, L., Schlessinger, D., Strachan, D.P., Hirschhorn, J.N., Assimes, T.L., Wichmann, H.E., Thorsteinsdottir, U., van Duijn, C.M., Stefansson, K., Cupples, L.A., Loos, R.J., Barroso, I., McCarthy, M.I., Fox, C.S., Mohlke, K.L., Lindgren, C.M., Heid, I.M., Jackson, A.U., Randall, J.C., Winkler, T.W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M.C., Speliotes, E.K., Mägi, R., Workalemahu, T., White, C.C., Bouatia-Naji, N., Harris, T.B., Berndt, S.I., Ingelsson, E., Willer, C.J., Weedon, M.N., Luan, J., Vedantam, S., Esko, T., Kilpeläinen, T.O., Kutalik, Z., Li, S., Monda, K.L., Dixon, A.L., Holmes, C.C., Kaplan, L.M., Liang, L., Min, J.L., Moffatt, M.F., Molony, C., Nicholson, G., Schadt, E.E., Zondervan, K.T., Feitosa, M.F., Ferreira, T., Allen, H.L., Weyant, R.J., Wheeler, E., Wood, A.R., MAGIC, Estrada, K., Goddard, M.E., Lettre, G., Mangino, M., Nyholt, D.R., Purcell, S., Smith, A.V., Visscher, P.M., Yang, J., McCarroll, S.A., Nemesh, J., Voight, B.F., Absher, D., Amin, N., Aspelund, T., Coin, L., Glazer, N.L., Hayward, C., Heard-Costa, N.L., Hottenga, J.J., Johansson, A., Johnson, T., Kaakinen, M., Kapur, K., Ketkar, S., Knowles, J.W., Kraft, P., Kraja, A.T., Lamina, C., Leitzmann, M.F., McKnight, B., Morris, A.P., Ong, K.K., Perry, J.R., Peters, M.J., Polasek, O., Prokopenko, I., Rayner, N.W., Ripatti, S., Rivadeneira, F., Robertson, N.R., Sanna, S., Sovio, U., Surakka, I., Teumer, A., van Wingerden, S., Vitart, V., Zhao, J.H., Cavalcanti-Proença, C., Chines, P.S., Fisher, E., Kulzer, J.R., Lecoeur, C., Narisu, N., Sandholt, C., Scott, L.J., Silander, K., Stark, K., Tammesoo, M.L., Teslovich, T.M., Timpson, N.J., Watanabe, R.M., Welch, R., Chasman, D.I., Cooper, M.N., Jansson, J.O., Kettunen, J., Lawrence, R.W., Pellikka, N., Perola, M., Vandenput, L., Alavere, H., Almgren, P., Atwood, L.D., Bennett, A.J., Biffar, R., Bonnycastle, L.L., Bornstein, S.R., Buchanan, T.A., Campbell, H., Day, I.N., Dei, M., Dörr, M., Elliott, P., Erdos, M.R., Eriksson, J.G., Freimer, N.B., Fu, M., Gaget, S., Geus, E.J., Gjesing, A.P., Grallert, H., Grässler, J., Groves, C.J., Guiducci, C., Hartikainen, A.L., Hassanali, N., Havulinna, A.S., Herzig, K.H., Hicks, A.A., Hui, J., Igl, W., Jousilahti, P., Jula, A., Kajantie, E., Kinnunen, L., Kolcic, I., Koskinen, S., Kovacs, P., Kroemer, H.K., Krzelj, V., Kuusisto, J., Kvaloy, K., Laitinen, J., Lantieri, O., Lathrop, G.M., Lokki, M.L., Luben, R.N., Ludwig, B., McArdle, W.L., McCarthy, A., Morken, M.A., Nelis, M., Neville, M.J., Paré, G., Parker, A.N., Peden, J.F., Pichler, I., Pietiläinen, K.H., Platou, C.G., Pouta, A., Ridderstråle, M., Samani, N.J., Saramies, J., Sinisalo, J., Smit, J.H., Strawbridge, R.J., Stringham, H.M., Swift, A.J., Teder-Laving, M., Thomson, B., Usala, G., van Meurs, J.B., van Ommen, G.J., Vatin, V., Volpato, C.B., Wallaschofski, H., Walters, G.B., Widen, E., Wild, S.H., Willemsen, G., Witte, D.R., Zgaga, L., Zitting, P., Beilby, J.P., James, A.L., Kähönen, M., Lehtimäki, T., Nieminen, M.S., Ohlsson, C., Palmer, L.J., Raitakari, O., Ridker, P.M., Stumvoll, M., Tönjes, A., Viikari, J., Balkau, B., Ben-Shlomo, Y., Bergman, R.N., Boeing, H., Smith, G.D., Ebrahim, S., Froguel, P., Hansen, T., Hengstenberg, C., Hveem, K., Isomaa, B., Jørgensen, T., Karpe, F., Khaw, K.T., Laakso, M., Lawlor, D.A., Marre, M., Meitinger, T., Metspalu, A., Midthjell, K., Pedersen, O., Salomaa, V., Schwarz, P.E., Tuomi, T., Tuomilehto, J., Valle, T.T., Wareham, N.J., Arnold, A.M., Beckmann, J.S., Bergmann, S., Boerwinkle, E., Boomsma, D.I., Caulfield, M.J., Collins, F.S., Eiriksdottir, G., Gudnason, V., Gyllensten, U., Hamsten, A., Hattersley, A.T., Hofman, A., Hu, F.B., Illig, T., Iribarren, C., Jarvelin, M.R., Kao, W.H., Kaprio, J., Launer, L.J., Munroe, P.B., Oostra, B., Penninx, B.W., Pramstaller, P.P., Psaty, B.M., Quertermous, T., Rissanen, A., Rudan, I., Shuldiner, A.R., Soranzo, N., Spector, T.D., Syvanen, A.C., Uda, M., Uitterlinden, A., Völzke, H., Vollenweider, P., Wilson, J.F., Witteman, J.C., Wright, A.F., Abecasis, G.R., Boehnke, M., Borecki, I.B., Deloukas, P., Frayling, T.M., Groop, L.C., Haritunians, T., Hunter, D.J., Kaplan, R.C., North, K.E., O'Connell, J.R., Peltonen, L., Schlessinger, D., Strachan, D.P., Hirschhorn, J.N., Assimes, T.L., Wichmann, H.E., Thorsteinsdottir, U., van Duijn, C.M., Stefansson, K., Cupples, L.A., Loos, R.J., Barroso, I., McCarthy, M.I., Fox, C.S., Mohlke, K.L., and Lindgren, C.M.
Abstract: Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
Published: 2010

11. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Author: Speliotes, E.K. (Elizabeth), Willer, C.J. (Cristen), Berndt, S.I. (Sonja), Monda, K.L. (Keri), Thorleifsson, G. (Gudmar), Jackson, A.U. (Anne), Allen, H.L., Lindgren, C.M. (Cecilia), Luan, J., Mägi, R. (Reedik), Randall, J.C. (Joshua), Vedantam, S. (Sailaja), Winkler, T.W. (Thomas), Qi, L. (Lu), Workalemahu, T. (Tsegaselassie), Heid, I.M. (Iris), Steinthorsdottir, V. (Valgerdur), Stringham, H.M. (Heather), Wheeler, E. (Eleanor), Wood, A.R. (Andrew), Ferreira, T. (Teresa), Weyant, R.J. (Robert), Segrè, A.V. (Ayellet), Eestrada, K. (Karol), Liang, L. (Liming), Nemesh, J. (James), Park, J.H., Gustafsson, S. (Stefan), Kilpeläinen, T.O. (Tuomas), Yang, J. (Joanna), Bouatia-Naji, N. (Nabila), Eesko, T. (Tõnu), Feitosa, M.F. (Mary Furlan), Kutalik, Z. (Zoltán), Mangino, M. (Massimo), Raychaudhuri, S. (Soumya), Scherag, A. (Andre), Smith, A.V. (Albert Vernon), Welch, R.P. (Ryan), Zhao, J.H. (Jing Hua), Aben, K.K.H. (Katja), Absher, D. (Devin), Amin, N. (Najaf), Dixon, A.L. (Anna), Fisher, E. (Eeva), Glazer, N.L. (Nicole), Goddard, M.E. (Michael), Heard-Costa, N.L. (Nancy), Hoesel, V. (Volker), Hottenga, J.J. (Jouke Jan), Johansson, A. (Åsa), Johnson, T. (Toby), Ketkar, S. (Shamika), Lamina, C. (Claudia), Li, S. (Shengxu), Moffatt, M.F. (Miriam), Myers, R.H. (Richard), Narisu, N. (Narisu), Perry, J.R.B. (John), Peters, M.J. (Marjolein), Preuss, M. (Michael), Ripatti, S. (Samuli), Rivadeneira Ramirez, F. (Fernando), Sandholt, C. (Camilla), Scott, L.J. (Laura), Timpson, N.J. (Nicholas), Tyrer, J.P. (Jonathan), Wingerden, S. (Sophie) van, White, C.C. (Charles), Wiklund, F. (Fredrik), Barlassina, C. (Christina), Chasman, D.I. (Daniel), Cooper, M.N. (Matthew), Jansson, J.O., Lawrence, R.W. (Robert), Pellikka, N. (Niina), Prokopenko, I. (Inga), Shi, J. (Jianxin), Thiering, E. (Eelisabeth), Alavere, H. (Helene), Alibrandi, M.T.S. (Maria), Almgren, P. (Peter), Arnold, A.M. (Alice), Aspelund, T. (Thor), Atwood, L.D. (Larry), Balkau, B. (Beverley), Balmforth, A.J. (Anthony), Bennett, A.J. (Amanda), Ben-Shlomo, Y., Bergman, R.N. (Richard), Bergmann, S.M. (Sven), Biebermann, H. (Heike), Blakemore, A.I.F. (Alexandra), Boes, T. (Tanja), Bonnycastle, L.L. (Lori), Bornstein, S.R. (Stefan), Brown, M.J. (Morris), Buchanan, T.A. (Thomas), Busonero, F., Campbell, H. (Harry), Cappuccio, F.P. (Francesco), Cavalcanti-Proença, C. (Christine), Chen, Y.D.I. (Yii-Der Ida), Chen, C.-M. (Chih-Mei), Chines, P.S. (Peter), Clarke, R., Coin, L. (Lachlan), Connell, J. (John), Day, I.N.M. (Ian), Heijer, M. (Martin) den, Duan, J. (Jubao), Eebrahim, S. (Shah), Eelliott, P. (Paul), Eelosua, R. (Roberto), Eeiriksdottir, G. (Gudny), Eerdos, M.R. (Micheal), Eeriksson, J.G. (Johan), Facheris, M.F. (Maurizio), Felix, S.B. (Stephan), Fischer-Posovszky, P. (Pamela), Folsom, A.R. (Aaron), Friedrich, N. (Nele), Freimer, N.B. (Nelson), Fu, M. (Mao), Gaget, S. (Stefan), Gejman, P.V. (Pablo), Geus, E.J.C. (Eco) de, Gieger, C. (Christian), Gjesing, A.P. (Anette), Goel, A. (Anuj), Goyette, P. (Philippe), Grallert, H. (Harald), Gräßler, J. (Jürgen), Greenawalt, D. (Danielle), Groves, C.J. (Christopher), Gudnason, V. (Vilmundur), Guiducci, C. (Candace), Hartikainen, A.L., Hassanali, N. (Neelam), Hall, A.S. (Alistair), Havulinna, A.S. (Aki), Hayward, C. (Caroline), Heath, A.C. (Andrew), Hengstenberg, C. (Christian), Hicks, A.A. (Andrew), Hinney, A. (Anke), Hofman, A. (Albert), Homuth, G. (Georg), Hui, J. (Jennie), Igl, W. (Wilmar), Iribarren, C. (Carlos), Isomaa, B. (Bo), Jacobs, K.B. (Kevin), Jarick, I. (Ivonne), Jewell, E. (Eelizabeth), John, U. (Ulrich), Jørgensen, T. (Torben), Jousilahti, P. (Pekka), Jula, A. (Antti), Kaakinen, M. (Marika), Kajantie, E. (Eero), Kaplan, R.C. (Robert), Kathiresan, S. (Sekar), Kettunen, J. (Johannes), Kinnunen, L. (Leena), Knowles, J.W. (Joshua), Kolcic, I. (Ivana), König, I.R. (Inke), Koskinen, S. (Seppo), Kovacs, P. (Peter), Kusisto, J. (Johanna), Kraft, P. (Peter), Kvaløy, K. (Kirsti), Laitinen, J. (Jaana), Lantieri, O. (Olivier), Lanzani, C. (Chiara), Launer, L.J. (Lenore), Lecoeur, C. (Cécile), Lehtimäki, T. (Terho), Lettre, G. (Guillaume), Liu, J. (Jianjun), Lokki, M.L., Lorentzon, M. (Mattias), Luben, R.N. (Robert), Ludwig, B. (Barbara), Manunta, P. (Paolo), Marek, D. (Diana), Marre, M. (Michel), Martin, N.G. (Nicholas), McArdle, W.L. (Wendy), McCarthy, M.I. (Mark), McKnight, B. (Barbara), Meitinger, T. (Thomas), Melander, O. (Olle), Meyre, D. (David), Midthjell, K. (Kristian), Montgomery, G.W. (Grant), Morken, M.A. (Mario), Morris, A.D. (Andrew), Mulic, R. (Rosanda), Ngwa, J.S., Nelis, M. (Mari), Neville, M.J. (Matthew), Nyholt, D.R. (Dale), O'Ddonnell, C.J. (Christopher), O'Rahilly, S. (Stephen), Ong, K. (Ken), Oostra, B.A. (Ben), Paré, G. (Guillaume), Parker, A.N. (Alex), Perola, M. (Markus), Pichler, I. (Irene), Pietilainen, K.H. (Kirsi Hannele), Platou, C.P. (Carl), Polasek, O. (Ozren), Pouta, A. (Anneli), Rafelt, S. (Suzanne), Raitakari, O. (Olli), Rayner, N.W. (Nigel William), Ridderstråle, M. (Martin), Rief, W. (Winfried), Ruokonen, A. (Aimo), Robertson, N.R. (Neil), Rzehak, P. (Peter), Salomaa, V. (Veikko), Sanders, A.R. (Alan), Sandhu, M.S. (Manjinder), Sanna, S. (Serena), Saramies, J. (Jouko), Savolainen, M.J. (Markku), Schipf, S. (Sabine), Schreiber, S. (Stefan), Schunkert, H. (Heribert), Silander, K. (Kaisa), Sinisalo, J. (Juha), Siscovick, D.S. (David), Smit, J.H. (Jan), Soranzo, N. (Nicole), Sovio, U. (Ulla), Stephens, J. (Jonathan), Surakka, I. (Ida), Swift, A.J. (Amy), Tammesoo, M.L., Tardif, J.-C. (Jean-Claude), Teder-Laving, M. (Maris), Teslovich, T.M. (Tanya), Thompson, J.R. (John), Thomson, B. (Brian), Tönjes, A. (Anke), Tuomi, T. (Tiinamaija), Meurs, J.B.J. (Joyce) van, OMen, G.J. van, Vatin, V. (Vincent), Viikari, J. (Jorma), Visvikis-Siest, S. (Sophie), Vitart, V. (Veronique), Vogel, C.I. (Carla), Voight, B.F. (Benjamin), Waite, L. (Lindsay), Wallaschofski, H. (Henri), Walters, G.B. (Bragi), Widen, E. (Elisabeth), Wiegand, S. (Susanna), Wild, S.H. (Sarah), Willemsen, G.A.H.M. (Gonneke), Witte, D.R. (Deniel), Witteman, J.C.M. (Jacqueline), Xu, J. (Jianfeng), Zhang, Q. (Qunyuan), Zgaga, L. (Lina), Ziegler, A. (Andreas), Zitting, P. (Paavo), Beilby, J.P. (John), FarOqi, I.S. (Ssadaf), Hebebrand, J. (Johannes), Huikuri, H.V. (Heikki), James, A. (Alan), Kähönen, M. (Mika), Levinson, D.F. (Douglas), MacCiardi, F. (Fabio), Nieminen, M.S. (Markku), Ohlsson, C. (Claes), Palmer, C. (Cameron), Ridker, P.M. (Paul), Stumvoll, M. (Michael), Beckmann, J.S. (Jacques), Boeing, H. (Heiner), Boerwinkle, E.A. (Eric), Boomsma, D.I. (Dorret), Caulfield, M. (Mark), Chanock, S.J. (Stephen), Collins, F.S. (Francis), Cupples, L.A. (Adrienne), Eerdmann, J. (Jeanette), Frogue, P. (Philippe), Grönberg, H. (Henrik), Gyllensten, U. (Ulf), Hansen, T. (Torben), Harris, T.B. (Tamara), Hattersley, A.T. (Andrew), Hayes, R.B. (Richard), Heinrich, J. (Joachim), Hu, F.B. (Frank), Hveem, K. (Kristian), Illig, T. (Thomas), Järvelin, M.R., Kaprio, J. (Jaakko), Karpe, F. (Fredrik), Khaw, K-T. (Kay-Tee), Kiemeney, L.A.L.M. (Bart), Krude, H., Laakso, M. (Markku), Lawlor, D.A. (Debbie), Metspalu, A. (Andres), Munroe, P. (Patricia), Ouwehand, W.H. (Willem), Pedersen, O. (Oluf), Penninx, B.W.J.H. (Brenda), Pramstaller, P.P. (Peter Paul), Quertermous, T. (Thomas), Reinehr, T. (Thomas), Rissanen, A. (Aila), Rudan, I. (Igor), Samani, N.J. (Nilesh), Schwarz, P.E.H. (Peter), Shuldiner, A.R. (Alan), Spector, T.D. (Timothy), Tuomilehto, J. (Jaakko), Uda, M. (Manuela), Uitterlinden, A.G. (André), Valle, T.T. (Timo), Wabitsch, M. (Martin), Waeber, G. (Gérard), Wareham, N.J. (Nick), Watkins, H. (Hugh), Wilson, J.F. (James), Wright, A.F. (Alan), Zillikens, M.C. (Carola), ChatterjE, N. (Nilanjan), McCarroll, S.A. (Steve), Purcell, S. (Shaun), Schadt, E.E. (Eric), Visscher, P.M. (Peter), Assimes, T.L. (Themistocles), Borecki, I.B. (Ingrid), Deloukas, P. (Panagiotis), Fox, C.S. (Caroline), Groop, L. (Leif), Haritunians, T. (Talin), Hunter, D.J. (David), Mohlke, K.L. (Karen), O'ConneL, J.R. (Jeffrey), Peltonen, L. (Leena Johanna), SchleSinger, D. (David), Strachan, D.P. (David), Watanabe, R.M. (Richard), Duijn, C.M. (Cornelia) van, Wichmann, H.E. (Heinz Erich), Frayling, T.M. (Timothy), Thorsteinsdottir, U. (Unnur), Abecasis, G.R. (Gonçalo), Boehnke, M. (Michael), StefanSon, K. (Kari), North, K.E. (Kari), McArthy, M.I. (Mark), Hirschhorn, J.N. (Joel), IngelSon, E. (Erik), Loos, R.J.F. (Ruth), Weedon, M.N. (Michael), Speliotes, E.K. (Elizabeth), Willer, C.J. (Cristen), Berndt, S.I. (Sonja), Monda, K.L. (Keri), Thorleifsson, G. (Gudmar), Jackson, A.U. (Anne), Allen, H.L., Lindgren, C.M. (Cecilia), Luan, J., Mägi, R. (Reedik), Randall, J.C. (Joshua), Vedantam, S. (Sailaja), Winkler, T.W. (Thomas), Qi, L. (Lu), Workalemahu, T. (Tsegaselassie), Heid, I.M. (Iris), Steinthorsdottir, V. (Valgerdur), Stringham, H.M. (Heather), Wheeler, E. (Eleanor), Wood, A.R. (Andrew), Ferreira, T. (Teresa), Weyant, R.J. (Robert), Segrè, A.V. (Ayellet), Eestrada, K. (Karol), Liang, L. (Liming), Nemesh, J. (James), Park, J.H., Gustafsson, S. (Stefan), Kilpeläinen, T.O. (Tuomas), Yang, J. (Joanna), Bouatia-Naji, N. (Nabila), Eesko, T. (Tõnu), Feitosa, M.F. (Mary Furlan), Kutalik, Z. (Zoltán), Mangino, M. (Massimo), Raychaudhuri, S. (Soumya), Scherag, A. (Andre), Smith, A.V. (Albert Vernon), Welch, R.P. (Ryan), Zhao, J.H. (Jing Hua), Aben, K.K.H. (Katja), Absher, D. (Devin), Amin, N. (Najaf), Dixon, A.L. (Anna), Fisher, E. (Eeva), Glazer, N.L. (Nicole), Goddard, M.E. (Michael), Heard-Costa, N.L. (Nancy), Hoesel, V. (Volker), Hottenga, J.J. (Jouke Jan), Johansson, A. (Åsa), Johnson, T. (Toby), Ketkar, S. (Shamika), Lamina, C. (Claudia), Li, S. (Shengxu), Moffatt, M.F. (Miriam), Myers, R.H. (Richard), Narisu, N. (Narisu), Perry, J.R.B. (John), Peters, M.J. (Marjolein), Preuss, M. (Michael), Ripatti, S. (Samuli), Rivadeneira Ramirez, F. (Fernando), Sandholt, C. (Camilla), Scott, L.J. (Laura), Timpson, N.J. (Nicholas), Tyrer, J.P. (Jonathan), Wingerden, S. (Sophie) van, White, C.C. (Charles), Wiklund, F. (Fredrik), Barlassina, C. (Christina), Chasman, D.I. (Daniel), Cooper, M.N. (Matthew), Jansson, J.O., Lawrence, R.W. (Robert), Pellikka, N. (Niina), Prokopenko, I. (Inga), Shi, J. (Jianxin), Thiering, E. (Eelisabeth), Alavere, H. (Helene), Alibrandi, M.T.S. (Maria), Almgren, P. (Peter), Arnold, A.M. (Alice), Aspelund, T. (Thor), Atwood, L.D. (Larry), Balkau, B. (Beverley), Balmforth, A.J. (Anthony), Bennett, A.J. (Amanda), Ben-Shlomo, Y., Bergman, R.N. (Richard), Bergmann, S.M. (Sven), Biebermann, H. (Heike), Blakemore, A.I.F. (Alexandra), Boes, T. (Tanja), Bonnycastle, L.L. (Lori), Bornstein, S.R. (Stefan), Brown, M.J. (Morris), Buchanan, T.A. (Thomas), Busonero, F., Campbell, H. (Harry), Cappuccio, F.P. (Francesco), Cavalcanti-Proença, C. (Christine), Chen, Y.D.I. (Yii-Der Ida), Chen, C.-M. (Chih-Mei), Chines, P.S. (Peter), Clarke, R., Coin, L. (Lachlan), Connell, J. (John), Day, I.N.M. (Ian), Heijer, M. (Martin) den, Duan, J. (Jubao), Eebrahim, S. (Shah), Eelliott, P. (Paul), Eelosua, R. (Roberto), Eeiriksdottir, G. (Gudny), Eerdos, M.R. (Micheal), Eeriksson, J.G. (Johan), Facheris, M.F. (Maurizio), Felix, S.B. (Stephan), Fischer-Posovszky, P. (Pamela), Folsom, A.R. (Aaron), Friedrich, N. (Nele), Freimer, N.B. (Nelson), Fu, M. (Mao), Gaget, S. (Stefan), Gejman, P.V. (Pablo), Geus, E.J.C. (Eco) de, Gieger, C. (Christian), Gjesing, A.P. (Anette), Goel, A. (Anuj), Goyette, P. (Philippe), Grallert, H. (Harald), Gräßler, J. (Jürgen), Greenawalt, D. (Danielle), Groves, C.J. (Christopher), Gudnason, V. (Vilmundur), Guiducci, C. (Candace), Hartikainen, A.L., Hassanali, N. (Neelam), Hall, A.S. (Alistair), Havulinna, A.S. (Aki), Hayward, C. (Caroline), Heath, A.C. (Andrew), Hengstenberg, C. (Christian), Hicks, A.A. (Andrew), Hinney, A. (Anke), Hofman, A. (Albert), Homuth, G. (Georg), Hui, J. (Jennie), Igl, W. (Wilmar), Iribarren, C. (Carlos), Isomaa, B. (Bo), Jacobs, K.B. (Kevin), Jarick, I. (Ivonne), Jewell, E. (Eelizabeth), John, U. (Ulrich), Jørgensen, T. (Torben), Jousilahti, P. (Pekka), Jula, A. (Antti), Kaakinen, M. (Marika), Kajantie, E. (Eero), Kaplan, R.C. (Robert), Kathiresan, S. (Sekar), Kettunen, J. (Johannes), Kinnunen, L. (Leena), Knowles, J.W. (Joshua), Kolcic, I. (Ivana), König, I.R. (Inke), Koskinen, S. (Seppo), Kovacs, P. (Peter), Kusisto, J. (Johanna), Kraft, P. (Peter), Kvaløy, K. (Kirsti), Laitinen, J. (Jaana), Lantieri, O. (Olivier), Lanzani, C. (Chiara), Launer, L.J. (Lenore), Lecoeur, C. (Cécile), Lehtimäki, T. (Terho), Lettre, G. (Guillaume), Liu, J. (Jianjun), Lokki, M.L., Lorentzon, M. (Mattias), Luben, R.N. (Robert), Ludwig, B. (Barbara), Manunta, P. (Paolo), Marek, D. (Diana), Marre, M. (Michel), Martin, N.G. (Nicholas), McArdle, W.L. (Wendy), McCarthy, M.I. (Mark), McKnight, B. (Barbara), Meitinger, T. (Thomas), Melander, O. (Olle), Meyre, D. (David), Midthjell, K. (Kristian), Montgomery, G.W. (Grant), Morken, M.A. (Mario), Morris, A.D. (Andrew), Mulic, R. (Rosanda), Ngwa, J.S., Nelis, M. (Mari), Neville, M.J. (Matthew), Nyholt, D.R. (Dale), O'Ddonnell, C.J. (Christopher), O'Rahilly, S. (Stephen), Ong, K. (Ken), Oostra, B.A. (Ben), Paré, G. (Guillaume), Parker, A.N. (Alex), Perola, M. (Markus), Pichler, I. (Irene), Pietilainen, K.H. (Kirsi Hannele), Platou, C.P. (Carl), Polasek, O. (Ozren), Pouta, A. (Anneli), Rafelt, S. (Suzanne), Raitakari, O. (Olli), Rayner, N.W. (Nigel William), Ridderstråle, M. (Martin), Rief, W. (Winfried), Ruokonen, A. (Aimo), Robertson, N.R. (Neil), Rzehak, P. (Peter), Salomaa, V. (Veikko), Sanders, A.R. (Alan), Sandhu, M.S. (Manjinder), Sanna, S. (Serena), Saramies, J. (Jouko), Savolainen, M.J. (Markku), Schipf, S. (Sabine), Schreiber, S. (Stefan), Schunkert, H. (Heribert), Silander, K. (Kaisa), Sinisalo, J. (Juha), Siscovick, D.S. (David), Smit, J.H. (Jan), Soranzo, N. (Nicole), Sovio, U. (Ulla), Stephens, J. (Jonathan), Surakka, I. (Ida), Swift, A.J. (Amy), Tammesoo, M.L., Tardif, J.-C. (Jean-Claude), Teder-Laving, M. (Maris), Teslovich, T.M. (Tanya), Thompson, J.R. (John), Thomson, B. (Brian), Tönjes, A. (Anke), Tuomi, T. (Tiinamaija), Meurs, J.B.J. (Joyce) van, OMen, G.J. van, Vatin, V. (Vincent), Viikari, J. (Jorma), Visvikis-Siest, S. (Sophie), Vitart, V. (Veronique), Vogel, C.I. (Carla), Voight, B.F. (Benjamin), Waite, L. (Lindsay), Wallaschofski, H. (Henri), Walters, G.B. (Bragi), Widen, E. (Elisabeth), Wiegand, S. (Susanna), Wild, S.H. (Sarah), Willemsen, G.A.H.M. (Gonneke), Witte, D.R. (Deniel), Witteman, J.C.M. (Jacqueline), Xu, J. (Jianfeng), Zhang, Q. (Qunyuan), Zgaga, L. (Lina), Ziegler, A. (Andreas), Zitting, P. (Paavo), Beilby, J.P. (John), FarOqi, I.S. (Ssadaf), Hebebrand, J. (Johannes), Huikuri, H.V. (Heikki), James, A. (Alan), Kähönen, M. (Mika), Levinson, D.F. (Douglas), MacCiardi, F. (Fabio), Nieminen, M.S. (Markku), Ohlsson, C. (Claes), Palmer, C. (Cameron), Ridker, P.M. (Paul), Stumvoll, M. (Michael), Beckmann, J.S. (Jacques), Boeing, H. (Heiner), Boerwinkle, E.A. (Eric), Boomsma, D.I. (Dorret), Caulfield, M. (Mark), Chanock, S.J. (Stephen), Collins, F.S. (Francis), Cupples, L.A. (Adrienne), Eerdmann, J. (Jeanette), Frogue, P. (Philippe), Grönberg, H. (Henrik), Gyllensten, U. (Ulf), Hansen, T. (Torben), Harris, T.B. (Tamara), Hattersley, A.T. (Andrew), Hayes, R.B. (Richard), Heinrich, J. (Joachim), Hu, F.B. (Frank), Hveem, K. (Kristian), Illig, T. (Thomas), Järvelin, M.R., Kaprio, J. (Jaakko), Karpe, F. (Fredrik), Khaw, K-T. (Kay-Tee), Kiemeney, L.A.L.M. (Bart), Krude, H., Laakso, M. (Markku), Lawlor, D.A. (Debbie), Metspalu, A. (Andres), Munroe, P. (Patricia), Ouwehand, W.H. (Willem), Pedersen, O. (Oluf), Penninx, B.W.J.H. (Brenda), Pramstaller, P.P. (Peter Paul), Quertermous, T. (Thomas), Reinehr, T. (Thomas), Rissanen, A. (Aila), Rudan, I. (Igor), Samani, N.J. (Nilesh), Schwarz, P.E.H. (Peter), Shuldiner, A.R. (Alan), Spector, T.D. (Timothy), Tuomilehto, J. (Jaakko), Uda, M. (Manuela), Uitterlinden, A.G. (André), Valle, T.T. (Timo), Wabitsch, M. (Martin), Waeber, G. (Gérard), Wareham, N.J. (Nick), Watkins, H. (Hugh), Wilson, J.F. (James), Wright, A.F. (Alan), Zillikens, M.C. (Carola), ChatterjE, N. (Nilanjan), McCarroll, S.A. (Steve), Purcell, S. (Shaun), Schadt, E.E. (Eric), Visscher, P.M. (Peter), Assimes, T.L. (Themistocles), Borecki, I.B. (Ingrid), Deloukas, P. (Panagiotis), Fox, C.S. (Caroline), Groop, L. (Leif), Haritunians, T. (Talin), Hunter, D.J. (David), Mohlke, K.L. (Karen), O'ConneL, J.R. (Jeffrey), Peltonen, L. (Leena Johanna), SchleSinger, D. (David), Strachan, D.P. (David), Watanabe, R.M. (Richard), Duijn, C.M. (Cornelia) van, Wichmann, H.E. (Heinz Erich), Frayling, T.M. (Timothy), Thorsteinsdottir, U. (Unnur), Abecasis, G.R. (Gonçalo), Boehnke, M. (Michael), StefanSon, K. (Kari), North, K.E. (Kari), McArthy, M.I. (Mark), Hirschhorn, J.N. (Joel), IngelSon, E. (Erik), Loos, R.J.F. (Ruth), and Weedon, M.N. (Michael)
Abstract: Obesity is globaLy prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined aSociations betwEn body maS index and ĝ̂1/42.8 miLion SNPs in up to 123,865 individuals with targeted foLow up of 42 SNPs in up to 125,931 aDitional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci aSociated with body maS index (P < 5-10-8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly aSociated loci may provide new insights into human body weight regulation.
Published: 2010
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12. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Author: Heid, I.M. (Iris), Jackson, A.U. (Anne), Randall, J.C. (Joshua), Winkler, T.W. (Thomas), Qi, L. (Lu), Ssteinthorsdottir, V. (Valgerdur), Tthorleifsson, G. (Ggudmar), Zillikens, M.C. (Carola), Sspeliotes, E.K. (Eelizabeth), Mägi, R. (Reedik), Workalemahu, T. (Tsegaselassie), White, C.C. (Charles), Bouatia-Naji, N. (Nabila), Harris, T.B. (Tamara), Berndt, S.I. (Sonja), Ingelsson, E. (Erik), Willer, C.J. (Cristen), Luan, J., Vedantam, S. (Sailaja), Eesko, T. (Tõnu), Kilpeläinen, T.O. (Tuomas), Kutalik, Z. (Zoltán), Li, S. (Shengxu), Monda, K.L. (Keri), Dixon, A.L. (Anna), Holmes, C. (Christopher), Kaplan, R.C. (Robert), Liang, L. (Liming), Min, J. (Josine), Moffatt, M.F. (Miriam), Molony, C. (Cliona), Nicholson, G. (Ggeorge), Sschadt, E.E. (Eeric), Zondervan, K.T. (Krina), Feitosa, M.F. (Mary Furlan), Ferreira, T. (Teresa), Allen, H.L., Weyant, R.J. (Robert), Wheeler, E. (Eleanor), Wood, A.R. (Andrew), Eestrada, K. (Karol), Goddard, M.E. (Michael), Lettre, G. (Guillaume), Mangino, M. (Massimo), Nyholt, D.R. (Dale), Purcell, S. (Shaun), Ssmith, A.V., Visscher, P.M. (Peter), Yang, J. (Joanna), McCcarroll, S.A. (Ssteven), Nemesh, J. (James), Voight, B.F. (Benjamin), Absher, D. (Devin), Amin, N. (Najaf), Aspelund, T. (Thor), Coin, L. (Lachlan), Glazer, N.L. (Nicole), Hayward, C. (Caroline), Heard-Ccosta, N. (Nancy), Hottenga, J.J. (Jouke Jan), Johansson, A. (Åsa), Johnson, T. (Toby), Kaakinen, M. (Marika), Kapur, K. (Karen), Ketkar, S. (Shamika), Knowles, J.W. (Joshua), Kraft, P. (Peter), Kraja, A. (Aldi), Lamina, C. (Claudia), Leitzmann, M.F. (Michael), McKknight, B. (Barbara), Morris, A.D. (Andrew), Oong, K. (Ken), Perry, J.R.B. (John), Peters, M.J. (Marjolein), Polasek, O. (Ozren), Prokopenko, I. (Inga), Rayner, N.W. (Nigel William), Ripatti, S. (Samuli), Rivadeneira Ramirez, F. (Fernando), Robertson, N.R. (Neil), Sanna, S. (Serena), Sovio, U. (Ulla), Surakka, I. (Ida), Teumer, A. (Alexander), Wingerden, S. (Sophie) van, Vitart, V. (Veronique), Zhao, J.H. (Jing Hua), Cavalcanti-Proença, C. (Christine), Chines, P.S. (Peter), Fisher, E. (Eeva), Kulzer, J.R. (Jennifer), Lecoeur, C. (Cécile), Narisu, N. (Narisu), Sandholt, C. (Camilla), Scott, L.J. (Laura), Silander, K. (Kaisa), Stark, K. (Klaus), Tammesoo, M.L., Teslovich, T.M. (Tanya), Timpson, N.J. (Nicholas), Welch, R.P. (Ryan), Chasman, D.I. (Daniel), Cooper, M.N. (Matthew), Jansson, J.O., Kettunen, J. (Johannes), Wlawrence, R. (Robert), Pellikka, N. (Niina), Perola, M. (Markus), Vandenput, L. (Liesbeth), Alavere, H. (Helene), Almgren, P. (Peter), Atwood, L.D. (Larry), Bennett, A.J. (Amanda), Biffar, R. (Reiner), Bonnycastle, L.L. (Lori), Bornstein, S.R. (Stefan), Buchanan, T.A. (Thomas), Campbell, H. (Harry), Day, I.N.M. (Ian), Dei, M. (Mariano), Dörr, M. (Marcus), Eelliott, P. (Paul), Eerdos, M.R. (Micheal), Eeriksson, J.G. (Johan), Freimer, N.B. (Nelson), Fu, M. (Mao), Gaget, S. (Stefan), Geus, E.J.C. (Eco) de, Gjesing, A.P. (Anette), Grallert, H. (Harald), Gräßler, J. (Jürgen), Groves, C.J. (Christopher), Guiducci, C. (Candace), Hartikainen, A.L., Hassanali, N. (Neelam), Havulinna, A.S. (Aki), Herzig, K.H., Hicks, A.A. (Andrew), Hui, J. (Jennie), Igl, W. (Wilmar), Jousilahti, P. (Pekka), Jula, A. (Antti), Kajantie, E. (Eero), Kinnunen, L. (Leena), Kolcic, I. (Ivana), Koskinen, S. (Seppo), Kovacs, P. (Peter), Kroemer, H.K. (Heyo), Krzelj, V. (Vjekoslav), Kuusisto, J. (Johanna), Kvaløy, K. (Kirsti), Laitinen, J. (Jaana), Lantieri, O. (Olivier), Lathrop, G.M. (Mark), Lokki, M.L., Luben, R.N. (Robert), Ludwig, B. (Barbara), McArdle, W.L. (Wendy), McCcarthy, A. (Anne), Morken, M.A. (Mario), Nelis, M. (Mari), Neville, M.J. (Matthew), Paré, G. (Guillaume), Parker, A.N. (Alex), Peden, J. (John), Pichler, I. (Irene), Pietilainen, K.H. (Kirsi Hannele), Platou, C.P. (Carl), Pouta, A. (Anneli), Ridderstråle, M. (Martin), Samani, N.J. (Nilesh), Saramies, J. (Jouko), Sinisalo, J. (Juha), Smit, J.H. (Jan), Strawbridge, R.J. (Rona), Stringham, H.M. (Heather), Swift, A.J. (Amy), Teder-Llaving, M. (Maris), Thomson, B. (Brian), Usala, G., Meurs, J.B.J. (Joyce) van, Ommen, G.J. (Gert) van, Vatin, V. (Vincent), Volpato, C.B., Wallaschofski, H. (Henri), Walters, G.B. (Bragi), Widen, E. (Elisabeth), Wild, S.H. (Sarah), Willemsen, G.A.H.M. (Gonneke), Witte, D.R. (Deniel), Zgaga, L. (Lina), Zitting, P. (Paavo), Beilby, J.P. (John), James, A. (Alan), Kähönen, M. (Mika), Lehtimäki, T. (Terho), Nieminen, M.S. (Markku), Ohlsson, C. (Claes), Palmer, C. (Cameron), Raitakari, O. (Olli), Ridker, P.M. (Paul), Stumvoll, M. (Michael), Tönjes, A. (Anke), Viikari, J. (Jorma), Balkau, B. (Beverley), Ben-Shlomo, Y., Bergman, R.N. (Richard), Boeing, H. (Heiner), Smith, A.V. (Albert Vernon), Eebrahim, S. (Shah), Froguel, P. (Philippe), Hansen, T. (Torben), Hengstenberg, C. (Christian), Hveem, K. (Kristian), Isomaa, B. (Bo), Jørgensen, T. (Torben), Karpe, F. (Fredrik), Khaw, K-T. (Kay-Tee), Laakso, M. (Markku), Lawlor, D.A. (Debbie), Marre, M. (Michel), Meitinger, T. (Thomas), Metspalu, A. (Andres), Midthjell, K. (Kristian), Pedersen, O. (Oluf), Salomaa, V. (Veikko), Schwarz, P.E.H. (Peter), Tuomi, T. (Tiinamaija), Tuomilehto, J. (Jaakko), Valle, T.T. (Timo), Wareham, N.J. (Nick), Arnold, A.M. (Alice), Beckmann, J.S. (Jacques), Bergmann, S.M. (Sven), Boerwinkle, E.A. (Eric), Boomsma, D.I. (Dorret), Caulfield, M. (Mark), Collins, F.S. (Francis), Eeiriksdottir, G. (Gudny), Gudnason, V. (Vilmundur), Gyllensten, U. (Ulf), Hamsten, A. (Anders), Hattersley, A.T. (Andrew), Hofman, A. (Albert), Hu, F.B. (Frank), Illig, T. (Thomas), Iribarren, C. (Carlos), Järvelin, M.R., Kao, W.H.L. (Wen), Kaprio, J. (Jaakko), Launer, L.J. (Lenore), Munroe, P. (Patricia), Oostra, B.A. (Ben), Penninx, B.W.J.H. (Brenda), Pramstaller, P.P. (Peter Paul), Psaty, B.M. (Bruce), Quertermous, T. (Thomas), Rissanen, A. (Aila), Rudan, I. (Igor), Shuldiner, A.R. (Alan), Soranzo, N. (Nicole), Spector, T.D. (Timothy), Syvanen, A.C., Uda, M. (Manuela), Uitterlinden, A.G. (André), Völzke, H. (Henry), Vollenweider, P. (Peter), Wilson, J.F. (James), Witteman, J.C.M. (Jacqueline), Wright, A.F. (Alan), Abecasis, G.R. (Gonçalo), Boehnke, M. (Michael), Borecki, I.B. (Ingrid), Deloukas, P. (Panagiotis), Frayling, T.M. (Timothy), Groop, L. (Leif), Haritunians, T. (Talin), Hunter, D.J. (David), North, K.E. (Kari), O'Cconnell, J.R. (Jeffrey), Peltonen, L. (Leena Johanna), Schlessinger, D., Strachan, D.P. (David), Hirschhorn, J.N. (Joel), Assimes, T.L. (Themistocles), Wichmann, H.E. (Heinz Erich), Thorsteinsdottir, U. (Unnur), Duijn, C.M. (Cornelia) van, Stefansson, K. (Kari), Cupples, L.A. (Adrienne), Loos, R.J.F. (Ruth), Barroso, I.E. (Inês), Fox, C.S. (Caroline), Mohlke, K.L. (Karen), Lindgren, C.M. (Cecilia), Watanabe, R.M. (Richard), Weedon, M.N. (Michael), Heid, I.M. (Iris), Jackson, A.U. (Anne), Randall, J.C. (Joshua), Winkler, T.W. (Thomas), Qi, L. (Lu), Ssteinthorsdottir, V. (Valgerdur), Tthorleifsson, G. (Ggudmar), Zillikens, M.C. (Carola), Sspeliotes, E.K. (Eelizabeth), Mägi, R. (Reedik), Workalemahu, T. (Tsegaselassie), White, C.C. (Charles), Bouatia-Naji, N. (Nabila), Harris, T.B. (Tamara), Berndt, S.I. (Sonja), Ingelsson, E. (Erik), Willer, C.J. (Cristen), Luan, J., Vedantam, S. (Sailaja), Eesko, T. (Tõnu), Kilpeläinen, T.O. (Tuomas), Kutalik, Z. (Zoltán), Li, S. (Shengxu), Monda, K.L. (Keri), Dixon, A.L. (Anna), Holmes, C. (Christopher), Kaplan, R.C. (Robert), Liang, L. (Liming), Min, J. (Josine), Moffatt, M.F. (Miriam), Molony, C. (Cliona), Nicholson, G. (Ggeorge), Sschadt, E.E. (Eeric), Zondervan, K.T. (Krina), Feitosa, M.F. (Mary Furlan), Ferreira, T. (Teresa), Allen, H.L., Weyant, R.J. (Robert), Wheeler, E. (Eleanor), Wood, A.R. (Andrew), Eestrada, K. (Karol), Goddard, M.E. (Michael), Lettre, G. (Guillaume), Mangino, M. (Massimo), Nyholt, D.R. (Dale), Purcell, S. (Shaun), Ssmith, A.V., Visscher, P.M. (Peter), Yang, J. (Joanna), McCcarroll, S.A. (Ssteven), Nemesh, J. (James), Voight, B.F. (Benjamin), Absher, D. (Devin), Amin, N. (Najaf), Aspelund, T. (Thor), Coin, L. (Lachlan), Glazer, N.L. (Nicole), Hayward, C. (Caroline), Heard-Ccosta, N. (Nancy), Hottenga, J.J. (Jouke Jan), Johansson, A. (Åsa), Johnson, T. (Toby), Kaakinen, M. (Marika), Kapur, K. (Karen), Ketkar, S. (Shamika), Knowles, J.W. (Joshua), Kraft, P. (Peter), Kraja, A. (Aldi), Lamina, C. (Claudia), Leitzmann, M.F. (Michael), McKknight, B. (Barbara), Morris, A.D. (Andrew), Oong, K. (Ken), Perry, J.R.B. (John), Peters, M.J. (Marjolein), Polasek, O. (Ozren), Prokopenko, I. (Inga), Rayner, N.W. (Nigel William), Ripatti, S. (Samuli), Rivadeneira Ramirez, F. (Fernando), Robertson, N.R. (Neil), Sanna, S. (Serena), Sovio, U. (Ulla), Surakka, I. (Ida), Teumer, A. (Alexander), Wingerden, S. (Sophie) van, Vitart, V. (Veronique), Zhao, J.H. (Jing Hua), Cavalcanti-Proença, C. (Christine), Chines, P.S. (Peter), Fisher, E. (Eeva), Kulzer, J.R. (Jennifer), Lecoeur, C. (Cécile), Narisu, N. (Narisu), Sandholt, C. (Camilla), Scott, L.J. (Laura), Silander, K. (Kaisa), Stark, K. (Klaus), Tammesoo, M.L., Teslovich, T.M. (Tanya), Timpson, N.J. (Nicholas), Welch, R.P. (Ryan), Chasman, D.I. (Daniel), Cooper, M.N. (Matthew), Jansson, J.O., Kettunen, J. (Johannes), Wlawrence, R. (Robert), Pellikka, N. (Niina), Perola, M. (Markus), Vandenput, L. (Liesbeth), Alavere, H. (Helene), Almgren, P. (Peter), Atwood, L.D. (Larry), Bennett, A.J. (Amanda), Biffar, R. (Reiner), Bonnycastle, L.L. (Lori), Bornstein, S.R. (Stefan), Buchanan, T.A. (Thomas), Campbell, H. (Harry), Day, I.N.M. (Ian), Dei, M. (Mariano), Dörr, M. (Marcus), Eelliott, P. (Paul), Eerdos, M.R. (Micheal), Eeriksson, J.G. (Johan), Freimer, N.B. (Nelson), Fu, M. (Mao), Gaget, S. (Stefan), Geus, E.J.C. (Eco) de, Gjesing, A.P. (Anette), Grallert, H. (Harald), Gräßler, J. (Jürgen), Groves, C.J. (Christopher), Guiducci, C. (Candace), Hartikainen, A.L., Hassanali, N. (Neelam), Havulinna, A.S. (Aki), Herzig, K.H., Hicks, A.A. (Andrew), Hui, J. (Jennie), Igl, W. (Wilmar), Jousilahti, P. (Pekka), Jula, A. (Antti), Kajantie, E. (Eero), Kinnunen, L. (Leena), Kolcic, I. (Ivana), Koskinen, S. (Seppo), Kovacs, P. (Peter), Kroemer, H.K. (Heyo), Krzelj, V. (Vjekoslav), Kuusisto, J. (Johanna), Kvaløy, K. (Kirsti), Laitinen, J. (Jaana), Lantieri, O. (Olivier), Lathrop, G.M. (Mark), Lokki, M.L., Luben, R.N. (Robert), Ludwig, B. (Barbara), McArdle, W.L. (Wendy), McCcarthy, A. (Anne), Morken, M.A. (Mario), Nelis, M. (Mari), Neville, M.J. (Matthew), Paré, G. (Guillaume), Parker, A.N. (Alex), Peden, J. (John), Pichler, I. (Irene), Pietilainen, K.H. (Kirsi Hannele), Platou, C.P. (Carl), Pouta, A. (Anneli), Ridderstråle, M. (Martin), Samani, N.J. (Nilesh), Saramies, J. (Jouko), Sinisalo, J. (Juha), Smit, J.H. (Jan), Strawbridge, R.J. (Rona), Stringham, H.M. (Heather), Swift, A.J. (Amy), Teder-Llaving, M. (Maris), Thomson, B. (Brian), Usala, G., Meurs, J.B.J. (Joyce) van, Ommen, G.J. (Gert) van, Vatin, V. (Vincent), Volpato, C.B., Wallaschofski, H. (Henri), Walters, G.B. (Bragi), Widen, E. (Elisabeth), Wild, S.H. (Sarah), Willemsen, G.A.H.M. (Gonneke), Witte, D.R. (Deniel), Zgaga, L. (Lina), Zitting, P. (Paavo), Beilby, J.P. (John), James, A. (Alan), Kähönen, M. (Mika), Lehtimäki, T. (Terho), Nieminen, M.S. (Markku), Ohlsson, C. (Claes), Palmer, C. (Cameron), Raitakari, O. (Olli), Ridker, P.M. (Paul), Stumvoll, M. (Michael), Tönjes, A. (Anke), Viikari, J. (Jorma), Balkau, B. (Beverley), Ben-Shlomo, Y., Bergman, R.N. (Richard), Boeing, H. (Heiner), Smith, A.V. (Albert Vernon), Eebrahim, S. (Shah), Froguel, P. (Philippe), Hansen, T. (Torben), Hengstenberg, C. (Christian), Hveem, K. (Kristian), Isomaa, B. (Bo), Jørgensen, T. (Torben), Karpe, F. (Fredrik), Khaw, K-T. (Kay-Tee), Laakso, M. (Markku), Lawlor, D.A. (Debbie), Marre, M. (Michel), Meitinger, T. (Thomas), Metspalu, A. (Andres), Midthjell, K. (Kristian), Pedersen, O. (Oluf), Salomaa, V. (Veikko), Schwarz, P.E.H. (Peter), Tuomi, T. (Tiinamaija), Tuomilehto, J. (Jaakko), Valle, T.T. (Timo), Wareham, N.J. (Nick), Arnold, A.M. (Alice), Beckmann, J.S. (Jacques), Bergmann, S.M. (Sven), Boerwinkle, E.A. (Eric), Boomsma, D.I. (Dorret), Caulfield, M. (Mark), Collins, F.S. (Francis), Eeiriksdottir, G. (Gudny), Gudnason, V. (Vilmundur), Gyllensten, U. (Ulf), Hamsten, A. (Anders), Hattersley, A.T. (Andrew), Hofman, A. (Albert), Hu, F.B. (Frank), Illig, T. (Thomas), Iribarren, C. (Carlos), Järvelin, M.R., Kao, W.H.L. (Wen), Kaprio, J. (Jaakko), Launer, L.J. (Lenore), Munroe, P. (Patricia), Oostra, B.A. (Ben), Penninx, B.W.J.H. (Brenda), Pramstaller, P.P. (Peter Paul), Psaty, B.M. (Bruce), Quertermous, T. (Thomas), Rissanen, A. (Aila), Rudan, I. (Igor), Shuldiner, A.R. (Alan), Soranzo, N. (Nicole), Spector, T.D. (Timothy), Syvanen, A.C., Uda, M. (Manuela), Uitterlinden, A.G. (André), Völzke, H. (Henry), Vollenweider, P. (Peter), Wilson, J.F. (James), Witteman, J.C.M. (Jacqueline), Wright, A.F. (Alan), Abecasis, G.R. (Gonçalo), Boehnke, M. (Michael), Borecki, I.B. (Ingrid), Deloukas, P. (Panagiotis), Frayling, T.M. (Timothy), Groop, L. (Leif), Haritunians, T. (Talin), Hunter, D.J. (David), North, K.E. (Kari), O'Cconnell, J.R. (Jeffrey), Peltonen, L. (Leena Johanna), Schlessinger, D., Strachan, D.P. (David), Hirschhorn, J.N. (Joel), Assimes, T.L. (Themistocles), Wichmann, H.E. (Heinz Erich), Thorsteinsdottir, U. (Unnur), Duijn, C.M. (Cornelia) van, Stefansson, K. (Kari), Cupples, L.A. (Adrienne), Loos, R.J.F. (Ruth), Barroso, I.E. (Inês), Fox, C.S. (Caroline), Mohlke, K.L. (Karen), Lindgren, C.M. (Cecilia), Watanabe, R.M. (Richard), and Weedon, M.N. (Michael)
Abstract: Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9-10-9 to P = 1.8-10-40) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9-10-3 to P = 1.2-10-13). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
Published: 2010
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13. Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index

Author: Huth, C., Illig, T., Herder, C., Gieger, C., Grallert, H., Vollmert, C., Rathmann, W., Hamid, Y.H., Pedersen, Oluf, Hansen, T., Thorand, B., Meisinger, C., Doring, A., Klopp, N., Gohlke, H., Lieb, W., Hengstenberg, C., Lyssenko, V., Groop, L., Ireland, H., Stephens, J.W., Asterholm, I. Wernstedt, Jansson, J.O., Boeing, H., Mohlig, M., Stringham, H.M., Boehnke, M., Tuomilehto, J., Fernandez-Real, J.M., Lopez-Bermejo, A., Gallart, L., Vendrell, J., Humphries, S.E., Kronenberg, F., Wichmann, H.E., Heid, I.M., Huth, C., Illig, T., Herder, C., Gieger, C., Grallert, H., Vollmert, C., Rathmann, W., Hamid, Y.H., Pedersen, Oluf, Hansen, T., Thorand, B., Meisinger, C., Doring, A., Klopp, N., Gohlke, H., Lieb, W., Hengstenberg, C., Lyssenko, V., Groop, L., Ireland, H., Stephens, J.W., Asterholm, I. Wernstedt, Jansson, J.O., Boeing, H., Mohlig, M., Stringham, H.M., Boehnke, M., Tuomilehto, J., Fernandez-Real, J.M., Lopez-Bermejo, A., Gallart, L., Vendrell, J., Humphries, S.E., Kronenberg, F., Wichmann, H.E., and Heid, I.M.
Abstract: Udgivelsesdato: 2009
Published: 2009

14. Därför säger vi nej till ”Förbifart Stockholm”

Author: Finnveden, Göran, Berggren, C, Brunsson, N, Cerin, P, Corvellec, H, Eckerman, I, Eldh, C, Falkemark, G, Frändberg, L, Gössling, S, Hahn, T, Jakobsson, S, Jansson, J.O, Kaijser, A, Laestadius, S, Lundqvist, P, Murray, R, Mähler, K.-G, Nilsson, J.H, Odhnoff, J, Ohlsson, E, Ribbing, P, Rodhe, H, Strandberg, L.-G, Söderbaum, P, Trygger, C, Vilhelmsson, B, Övermark, I, Finnveden, Göran, Berggren, C, Brunsson, N, Cerin, P, Corvellec, H, Eckerman, I, Eldh, C, Falkemark, G, Frändberg, L, Gössling, S, Hahn, T, Jakobsson, S, Jansson, J.O, Kaijser, A, Laestadius, S, Lundqvist, P, Murray, R, Mähler, K.-G, Nilsson, J.H, Odhnoff, J, Ohlsson, E, Ribbing, P, Rodhe, H, Strandberg, L.-G, Söderbaum, P, Trygger, C, Vilhelmsson, B, and Övermark, I
Abstract: QC 20161116
Published: 2008

15. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

Author: Benjamin Voight, Guillaume Pare, Ruth Loos, Michael Preuss, Åsa Johansson, Eco De Geus, Michael Weedon, Marjo-Riitta Jarvelin, Joyce Van Meurs, Torben Jørgensen, Kirsi Pietiläinen, Nicole Glazer, Mattias Lorentzon, Braxton Mitchell, Nicole Soranzo, Patricia Munroe, Ozren Polasek, Elisabeth Thiering, Marika Kaakinen, Carla Vogel, Jennie Hui, Elina Hypponen, ROBERTO ELOSUA, Amanda Bennett, Michael Stumvoll, Andrew Hattersley, Peter P Pramstaller, Lambertus Kiemeney, Sophie Visvikis-Siest, Vilmundur Gudnason, John Whittaker, Aroon Hingorani, Thor Aspelund, Dale Nyholt, Mary Feitosa, Vimal Karani, Mika Kähönen, Lachlan Coin, Malcolm Dunlop, Josee Dupuis, Terho Lehtimäki, Peter Visscher, Katja Aben, Daniel Witte, Cyrus Cooper, Stefan Pilz, Willem Ouwehand, Eleanor Wheeler, Peter Kovacs, Debbie A Lawlor, Kevin Jacobs, Evropi Theodoratou, Hana Lango Allen, Rosanda Mulic, Rui Li, Stephen Kritchevsky, Philippe Froguel, Soumya Raychaudhuri, Cornelia Van Duijn, Andrew Wood, Chiara Lanzani, Tonu Esko, Sadaf Farooqi, Reedik Mägi, Gerard Waeber, Claes Ohlsson, André Scherag, Marcus Kleber, Thomas Meitinger, Lina Zgaga, Denise Houston, Karl Michaëlsson, Robert Weyant, Thomas Wang, Paul Elliott, Robert Luben, Albert Vernon Smith, MANUELA UDA, Gonneke Willemsen, Mark McCarthy, Cecilia Lindgren, Olle Melander, Igor Rudan, Maris Teder-Laving, Liesbeth Vandenput, Vimaleswaran, K, Berry, Dj, Lu, C, Tikkanen, E, Pilz, S, Hiraki, Lt, Cooper, Jd, Dastani, Z, Li, R, Houston, Dk, Wood, Ar, Michaëlsson, K, Vandenput, L, Zgaga, L, YERGES ARMSTRONG, Lm, Mccarthy, Mi, Dupuis, J, Kaakinen, M, Kleber, Me, Jameson, K, Arden, N, Raitakari, O, Viikari, J, Lohman, Kk, Ferrucci, L, Melhus, H, Ingelsson, E, Byberg, L, Lind, L, Lorentzon, M, Salomaa, V, Campbell, H, Dunlop, M, Mitchell, Bd, Herzig, Kh, Pouta, A, Hartikainen, Al, Manunta, Paolo, Streeten, Ea, Theodoratou, E, Jula, A, Wareham, Nj, Ohlsson, C, Frayling, Tm, Kritchevsky, Sb, Spector, Td, Richards, Jb, Lehtimäki, T, Ouwehand, Wh, Kraft, P, Cooper, C, März, W, Power, C, Loos, Rj, Wang, Tj, Järvelin, Mr, Whittaker, Jc, Hingorani, Ad, Hyppönen, E., Council, Medical Research, Biological Psychology, EMGO+ - Lifestyle, Overweight and Diabetes, Institute for Molecular Medicine Finland, Haartman Institute (-2014), Transplantation Laboratory, Vimaleswaran, Karani S, Berry, Diane J, Lu, Chen, Tikkanen, Emmi, Hyppönen, Elina, Genetic Investigation of Anthropometric Traits (GIANT) Consortium, Hinney, Anke (Beitragende*r), Scherag, Susann (Beitragende*r), Hebebrand, Johannes (Beitragende*r), Epidemiology and Data Science, Psychiatry, EMGO - Lifestyle, overweight and diabetes, Genetic Investigation of Anthropometric Traits-GIANT Consortium, Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A.U., Allen, H.L., Lindgren, C.M., Jian'an, L., Mägi, R., Randall, J.C., Vedantam, S., Winkler, T.W., Qi, L., Workalemahu, T., Heid, I.M., Steinthorsdottir, V., Stringham, H.M., Weedon, M.N., Wheeler, E., Wood, A.R., Ferreira, T., Weyant, R.J., Segrè, A.V., Estrada, K., Liang, L., Nemesh, J., Park, J.H., Gustafsson, S., Kilpeläinen, T.O., Yang, J., Bouatia-Naji, N., Tõnu, E., Feitosa, M.F., Kutalik, Z., Mangino, M., Raychaudhuri, S., Scherag, A., Smith, A.V., Welch, R., Zhao, J.H., Aben, K.K., Absher, D.M., Amin, N., Dixon, A.L., Fisher, E., Glazer, N.L., Goddard, M.E., Heard-Costa, N.L., Hoesel, V., Hottenga, J.J., Johansson, Å., Johnson, T., Ketkar, S., Lamina, C., Li, S., Moffatt, M.F., Myers, R.H., Narisu, N., Perry, J.R., Peters, M.J., Preuss, M., Ripatti, S., Rivadeneira, F., Sandholt, C., Scott, L.J., Timpson, N.J., Tyrer, J.P., van Wingerden, S., Watanabe, R.M., White, C.C., Wiklund, F., Barlassina, C., Chasman, D.I., Cooper, M.N., Jansson, J.O., Lawrence, R.W., Pellikka, N., Prokopenko, I., Shi, J., Thiering, E., Alavere, H., Alibrandi, M.T., Almgren, P., Arnold, A.M., Aspelund, T., Atwood, L.D., Balkau, B., Balmforth, A.J., Bennett, A.J., Ben-Shlomo, Y., Bergman, R.N., Bergmann, S., Biebermann, H., Blakemore, A.I., Boes, T., Bonnycastle, L.L., Bornstein, S.R., Brown, M.J., Buchanan, T.A., Busonero, F., Campbell, H., Cappuccio, F.P., Cavalcanti-Proença, C., Chen, Y.D., Chen, C.M., Chines, P.S., Clarke, R., Coin, L., Connell, J., Day, I.N., Heijer, M., Duan, J., Ebrahim, S., Elliott, P., Elosua, R., Eiriksdottir, G., Erdos, M.R., Eriksson, J.G., Facheris, M.F., Felix, S.B., Fischer-Posovszky, P., Folsom, A.R., Friedrich, N., Freimer, N.B., Fu, M., Gaget, S., Gejman, P.V., Geus, E.J., Gieger, C., Gjesing, A.P., Goel, A., Goyette, P., Grallert, H., Gräßler, J., Greenawalt, D.M., Groves, C.J., Gudnason, V., Guiducci, C., Hartikainen, A.L., Hassanali, N., Hall, A.S., Havulinna, A.S., Hayward, C., Heath, A.C., Hengstenberg, C., Hicks, A.A., Hinney, A., Hofman, A., Homuth, G., Hui, J., Igl, W., Iribarren, C., Isomaa, B., Jacobs, K.B., Jarick, I., Jewell, E., John, U., Jørgensen, T., Jousilahti, P., Jula, A., Kaakinen, M., Kajantie, E., Kaplan, L.M., Kathiresan, S., Kettunen, J., Kinnunen, L., Knowles, J.W., Kolcic, I., König, I.R., Koskinen, S., Kovacs, P., Kuusisto, J., Kraft, P., Kvaløy, K., Laitinen, J., Lantieri, O., Lanzani, C., Launer, L.J., Lecoeur, C., Lehtimäki, T., Lettre, G., Liu, J., Lokki, M.L., Lorentzon, M., Luben, R.N., Ludwig, B., Manunta, P., Marek, D., Marre, M., Martin, N.G., McArdle, W.L., McCarthy, A., McKnight, B., Meitinger, T., Melander, O., Meyre, D., Midthjell, K., Montgomery, G.W., Morken, M.A., Morris, A.P., Mulic, R., Ngwa, J.S., Nelis, M., Neville, M.J., Nyholt, D.R., O'Donnell, C.J., O'Rahilly, S., Ong, K.K., Oostra, B., Paré, G., Parker, A.N., Perola, M., Pichler, I., Pietiläinen, K.H., Platou, C.G., Polasek, O., Pouta, A., Rafelt, S., Raitakari, O., Rayner, N.W., Ridderstråle, M., Rief, W., Ruokonen, A., Robertson, N.R., Rzehak, P., Salomaa, V., Sanders, A.R., Sandhu, M.S., Sanna, S., Saramies, J., Savolainen, M.J., Scherag, S., Schipf, S., Schreiber, S., Schunkert, H., Silander, K., Sinisalo, J., Siscovick, D.S., Smit, J.H., Soranzo, N., Sovio, U., Stephens, J., Surakka, I., Swift, AJ., Tammesoo, M.L., Tardif, J.C., Teder-Laving, M., Teslovich, T.M., Thompson, J.R., Thomson, B., Tönjes, A., Tuomi, T., van Meurs, J.B., van Ommen, G.J., Vatin, V., Viikari, J., Visvikis-Siest, S., Vitart, V., Vogel, C.I., Voight, B.F., Waite, L.L., Wallaschofski, H., Walters, G.B., Widen, E., Wiegand, S., Wild, S.H., Willemsen, G., Witte, D.R., Witteman, J.C., Xu, J., Zhang, Q., Zgaga, L., Ziegler, A., Zitting, P., Beilby, J.P., Farooqi, I.S., Hebebrand, J., Huikuri, H.V., James, AL., Kähönen, M., Levinson, D.F., Macciardi, F., Nieminen, M.S., Ohlsson, C., Palmer, L.J., Ridker, P.M., Stumvoll, M., Beckmann, J.S., Boeing, H., Boerwinkle, E., Boomsma, D.I., Caulfield, M.J., Chanock, S.J., Collins, F.S., Cupples, L.A., Smith, G.D., Erdmann, J., Froguel, P., Grönberg, H., Gyllensten, U., Hall, P., Hansen, T., Harris, T.B., Hattersley, A.T., Hayes, R.B., Heinrich, J., Hu, F.B., Hveem, K., Illig, T., Jarvelin, M.R., Kaprio, J., Karpe, F., Khaw, K.T., Kiemeney, L.A., Krude, H., Laakso, M., Lawlor, D.A., Metspalu, A., Munroe, P.B., Ouwehand, W.H., Pedersen, O., Penninx, B.W., Peters, A., Pramstaller, P.P., Quertermous, T., Reinehr, T., Rissanen, A., Rudan, I., Samani, N.J., Schwarz, P.E., Shuldiner, A.R., Spector, T.D., Tuomilehto, J., Uda, M., Uitterlinden, A., Valle, T.T., Wabitsch, M., Waeber, G., Wareham, N.J., Watkins, H., Wilson, J.F., Wright, A.F., Zillikens, M.C., Chatterjee, N., McCarroll, S.A., Purcell, S., Schadt, E.E., Visscher, P.M., Assimes, T.L., Borecki, I.B., Deloukas, P., Fox, C.S., Groop, L.C., Haritunians, T., Hunter, D.J., Kaplan, R.C., Mohlke, K.L., O'Connell, J.R., Peltonen, L., Schlessinger, D., Strachan, D.P., van Duijn, C.M., Wichmann, H.E., Frayling, T.M., Thorsteinsdottir, U., Abecasis, G.R., Barroso, I., Boehnke, M., Stefansson, K., North, K.E., McCarthy, M.I., Hirschhorn, J.N., Ingelsson, E., Loos, R.J., Medical Research Council (MRC), and National Institute for Health Research
Subjects: Male, Netherlands Twin Register (NTR), Medicin och hälsovetenskap, obesity, 25-HYDROXYVITAMIN D, D INSUFFICIENCY, Epidemiology, Medizin, vitamin D, Aetiology, screening and detection [ONCOL 5], Medical and Health Sciences, Gastroenterology, Body Mass Index, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, GENETIC-VARIANTS, Medicine, 030212 general & internal medicine, Vitamin D, 2. Zero hunger, Genetics, Aged, 80 and over, Evidence-Based Medicine, Confounding, 11 Medical And Health Sciences, General Medicine, Middle Aged, 3. Good health, PREVALENCE, Europe, Phenotype, Genetic Epidemiology, Biological Markers, Female, Life Sciences & Biomedicine, Research Article, Vitamin, Adult, medicine.medical_specialty, vitamin D deficiency, genetic variants, Genetic Investigation of Anthropometric Traits-GIANT Consortium, European Continental Ancestry Group, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, body mass index, Polymorphism, Single Nucleotide, Risk Assessment, White People, COMMON OBESITY, 03 medical and health sciences, D DEFICIENCY, Medicine, General & Internal, SDG 3 - Good Health and Well-being, General & Internal Medicine, Internal medicine, Mendelian randomization, Vitamin D and neurology, INSTRUMENTAL VARIABLES, Humans, Genetic Predisposition to Disease, Obesity, GENOME-WIDE ASSOCIATION, Biology, Molecular epidemiology Aetiology, screening and detection [NCEBP 1], Aged, Science & Technology, Population Biology, business.industry, CARDIOVASCULAR-DISEASE RISK, ta3121, Mendelian Randomization Analysis, medicine.disease, Vitamin D Deficiency, BODY-MASS INDEX, chemistry, Genetic epidemiology, 3121 General medicine, internal medicine and other clinical medicine, Multivariate Analysis, North America, Genetic Polymorphism, Linear Models, business, Body mass index, Population Genetics, Biomarkers
Abstract: A mendelian randomization study based on data from multiple cohorts conducted by Karani Santhanakrishnan Vimaleswaran and colleagues re-examines the causal nature of the relationship between vitamin D levels and obesity., Background Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis. Methods and Findings We used information from 21 adult cohorts (up to 42,024 participants) with 12 BMI-related SNPs (combined in an allelic score) to produce an instrument for BMI and four SNPs associated with 25(OH)D (combined in two allelic scores, separately for genes encoding its synthesis or metabolism) as an instrument for vitamin D. Regression estimates for the IVs (allele scores) were generated within-study and pooled by meta-analysis to generate summary effects. Associations between vitamin D scores and BMI were confirmed in the Genetic Investigation of Anthropometric Traits (GIANT) consortium (n = 123,864). Each 1 kg/m2 higher BMI was associated with 1.15% lower 25(OH)D (p = 6.52×10−27). The BMI allele score was associated both with BMI (p = 6.30×10−62) and 25(OH)D (−0.06% [95% CI −0.10 to −0.02], p = 0.004) in the cohorts that underwent meta-analysis. The two vitamin D allele scores were strongly associated with 25(OH)D (p≤8.07×10−57 for both scores) but not with BMI (synthesis score, p = 0.88; metabolism score, p = 0.08) in the meta-analysis. A 10% higher genetically instrumented BMI was associated with 4.2% lower 25(OH)D concentrations (IV ratio: −4.2 [95% CI −7.1 to −1.3], p = 0.005). No association was seen for genetically instrumented 25(OH)D with BMI, a finding that was confirmed using data from the GIANT consortium (p≥0.57 for both vitamin D scores). Conclusions On the basis of a bi-directional genetic approach that limits confounding, our study suggests that a higher BMI leads to lower 25(OH)D, while any effects of lower 25(OH)D increasing BMI are likely to be small. Population level interventions to reduce BMI are expected to decrease the prevalence of vitamin D deficiency. Please see later in the article for the Editors' Summary, Editors' Summary Background Obesity—having an unhealthy amount of body fat—is increasing worldwide. In the US, for example, a third of the adult population is now obese. Obesity is defined as having a body mass index (BMI, an indicator of body fat calculated by dividing a person's weight in kilograms by their height in meters squared) of more than 30.0 kg/m2. Although there is a genetic contribution to obesity, people generally become obese by consuming food and drink that contains more energy than they need for their daily activities. Thus, obesity can be prevented by having a healthy diet and exercising regularly. Compared to people with a healthy weight, obese individuals have an increased risk of developing diabetes, heart disease and stroke, and tend to die younger. They also have a higher risk of vitamin D deficiency, another increasingly common public health concern. Vitamin D, which is essential for healthy bones as well as other functions, is made in the skin after exposure to sunlight but can also be obtained through the diet and through supplements. Why Was This Study Done? Observational studies cannot prove that obesity causes vitamin D deficiency because obese individuals may share other characteristics that reduce their circulating 25-hydroxy vitamin D [25(OH)D] levels (referred to as confounding). Moreover, observational studies cannot indicate whether the larger vitamin D storage capacity of obese individuals (vitamin D is stored in fatty tissues) lowers their 25(OH)D levels or whether 25(OH)D levels influence fat accumulation (reverse causation). If obesity causes vitamin D deficiency, monitoring and treating vitamin D deficiency might alleviate some of the adverse health effects of obesity. Conversely, if low vitamin D levels cause obesity, encouraging people to take vitamin D supplements might help to control the obesity epidemic. Here, the researchers use bi-directional “Mendelian randomization” to examine the direction and causality of the relationship between BMI and 25(OH)D. In Mendelian randomization, causality is inferred from associations between genetic variants that mimic the influence of a modifiable environmental exposure and the outcome of interest. Because gene variants do not change over time and are inherited randomly, they are not prone to confounding and are free from reverse causation. Thus, if a lower vitamin D status leads to obesity, genetic variants associated with lower 25(OH)D concentrations should be associated with higher BMI, and if obesity leads to a lower vitamin D status, then genetic variants associated with higher BMI should be associated with lower 25(OH)D concentrations. What Did the Researchers Do and Find? The researchers created a “BMI allele score” based on 12 BMI-related gene variants and two “25(OH)D allele scores,” which are based on gene variants that affect either 25(OH)D synthesis or breakdown. Using information on up to 42,024 participants from 21 studies, the researchers showed that the BMI allele score was associated with both BMI and with 25(OH)D levels among the study participants. Based on this information, they calculated that each 10% increase in BMI will lead to a 4.2% decrease in 25(OH)D concentrations. By contrast, although both 25(OH)D allele scores were strongly associated with 25(OH)D levels, neither score was associated with BMI. This lack of an association between 25(OH)D allele scores and obesity was confirmed using data from more than 100,000 individuals involved in 46 studies that has been collected by the GIANT (Genetic Investigation of Anthropometric Traits) consortium. What Do These Findings Mean? These findings suggest that a higher BMI leads to a lower vitamin D status whereas any effects of low vitamin D status on BMI are likely to be small. That is, these findings provide evidence for obesity as a causal factor in the development of vitamin D deficiency but not for vitamin D deficiency as a causal factor in the development of obesity. These findings suggest that population-level interventions to reduce obesity should lead to a reduction in the prevalence of vitamin D deficiency and highlight the importance of monitoring and treating vitamin D deficiency as a means of alleviating the adverse influences of obesity on health. Additional Information Please access these Web sites via the online version of this summary at http://dx.doi.org/10.1371/journal.pmed.1001383. The US Centers for Disease Control and Prevention provides information on all aspects of overweight and obesity (in English and Spanish); a data brief provides information about the vitamin D status of the US population The World Health Organization provides information on obesity (in several languages) The UK National Health Service Choices website provides detailed information about obesity and a link to a personal story about losing weight; it also provides information about vitamin D The International Obesity Taskforce provides information about the global obesity epidemic The US Department of Agriculture's ChooseMyPlate.gov website provides a personal healthy eating plan; the Weight-control Information Network is an information service provided for the general public and health professionals by the US National Institute of Diabetes and Digestive and Kidney Diseases (in English and Spanish) The US Office of Dietary Supplements provides information about vitamin D (in English and Spanish) MedlinePlus has links to further information about obesity and about vitamin D (in English and Spanish) Wikipedia has a page on Mendelian randomization (note: Wikipedia is a free online encyclopedia that anyone can edit; available in several languages) Overview and details of the collaborative large-scale genetic association study (D-CarDia) provide information about vitamin D and the risk of cardiovascular disease, diabetes and related traits
Published: 2013
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15. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

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