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1. Contents, Vol. 41, 1996

Author

Reinaldo Figueroa, Christer Uhlemann, Lale Kutlay, Manabu Kitao, Mohammad Ghazizadeh, W.A.J. Poppe, Vasilios Tanos, Aşhmet Gözen, Willy Davila, P. Daenens, Kubilay Vicdan, Magnus Fall, Antonio Gabriele, Yasuhide Ariyuki, Serdar Oguz, J.M. Lauweryns, T. Motta, Hiroshi Minaguchi, Bo L. Ohlssor, G. Daxenbichler, Cristina Bonazzi, F.A. Van Assche, Ira Schwartz, Oya Gökmen, Joseph G. Schenker, Kohkichi Hata, Fabio Landoni, R. Peeters, H. Kirchler, M. Drijkoningen, Luis A. Bracero, Andrea Maneo, Ömer Cobanoglu, Atike Bilge Şener, Aby Lewin, Hideomi Ogawa, Daisaku Senoh, Leopoldo Falsetti, Ian Milsom, Ken Makihar, H. Schröcksnadel, P.S. Ide, Neslihan Carda Seçkin, Eyüp Ekici, Debra Beneck, Michiyoshi Taga, Michiko Yamanaka, Paola Maggioni, Toshiyuki Hata, Walter Vegetti, Kenneth R. Shroyer, Tsutomu Araki, Gennaro Cormio, Showa Aoki, Inger Hahn, Michal Neiger, Peter Ekelund, John Coleman, A. Bergant, Gershom Zajicek, Pier Giorgio Crosignani, Maria E. Aguero-Rosenfeld, Levent Alaybeyoglu, G. Testa, Antonio Pellegrino, and Shevach Friedler

Subjects
Reproductive Medicine, Obstetrics and Gynecology
Published
1996
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2. Contents, Vol. 34, 1992

Author

M. Isahakia, Ferit Ö. Saraçoğlu, C.S. Bambra, G. Steckel-Berger, Cristina Ndobe, Michael Deutsch, H. Kimura, N. Furuhashi, H. Nagae, Jerome H. Check, C. Campobasso, D. Giulini, F. Pansini, Roger Karlsson, D. de Paoli, Bryan Larsen, D. Dapunt, Beth Vetter, S. Yagel, Helena Tinkanen, P.R. Koninckx, Leif Eriksson, F.J. Cornillie, Kerstin Nilsson, Gun Heimer, H.S. Schröcksnadel, J. Bódis, Ronald J. Stanek, M.M. Serra, Moshe Bronstein, A. Yajima, M. Hamoria, H.-R. Tinneberg, R. Goshen, E. Davies, Deborah Lurie, H. Hochner-Celnikier, Anders Hernborg, Y. Lavy, Ph. Cledon, Fikret Tanzer, Tamer Mungan, Benedita da Silva, V. Hanf, F. Levato, Jerker Liljestrand, A.T. Török, Erkki Kujansuu, M. Tsujiei, Mohammad E. Shubair, T.M. D'Hooghe, Staffan Edén, Sandra White, J.M. Lauweryns, Bo von Schoultz, B. Sitte, and Staffan Bergström

Subjects
Reproductive Medicine, Obstetrics and Gynecology
Published
1992
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3. Subject Index Vol. 41 1996

Author

Inger Hahn, Magnus Fall, Michiko Yamanaka, Ira Schwartz, Ian Milsom, H. Schröcksnadel, Serdar Oguz, Neslihan Carda Seçkin, Kohkichi Hata, Vasilios Tanos, Walter Vegetti, Willy Davila, Mohammad Ghazizadeh, M. Drijkoningen, Maria E. Aguero-Rosenfeld, Ken Makihar, Joseph G. Schenker, Paola Maggioni, Kenneth R. Shroyer, Debra Beneck, Pier Giorgio Crosignani, Fabio Landoni, Reinaldo Figueroa, Gennaro Cormio, Tsutomu Araki, Shevach Friedler, Toshiyuki Hata, Ömer Çobanoğlu, Kubilay Vicdan, Peter Ekelund, Hideomi Ogawa, G. Daxenbichler, G. Testa, Antonio Pellegrino, Andrea Maneo, John Coleman, Michiyoshi Taga, T. Motta, Antonio Gabriele, Hiroshi Minaguchi, Atike Bilge Şener, Oya Gökmen, Bo L. Ohlssor, H. Kirchler, Manabu Kitao, A. Bergant, P.S. Ide, Luis A. Bracero, Lale Kutlay, Eyüp Ekici, Michal Neiger, W.A.J. Poppe, Yasuhide Ariyuki, F.A. Van Assche, Leopoldo Falsetti, Cristina Bonazzi, Aby Lewin, Aşhmet Gözen, J.M. Lauweryns, Levent Alaybeyoglu, Showa Aoki, Christer Uhlemann, R. Peeters, Daisaku Senoh, P. Daenens, and Gershom Zajicek

Subjects
Index (economics), Reproductive Medicine, Statistics, Obstetrics and Gynecology, Subject (documents), Mathematics
Published
1996
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4. Biochemical and histochemical analysis of steroid hormone binding sites in human primary breast cancer

Author

William De Loecker, Luc Dekeyser, Jan Roelens, Jacques Stuyck, J.M. Lauweryns, Janssens Jp, Kris Pylyser, and Jan Bekaert

Subjects
Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Cancer, Estrogen receptor, Biology, medicine.disease, Steroid, chemistry.chemical_compound, Steroid hormone, Endocrinology, Oncology, chemistry, Internal medicine, Isothiocyanate, medicine, Steroid hormone binding, Receptor, hormones, hormone substitutes, and hormone antagonists, Hormone
Abstract

Mammary carcinoma tissue from 514 primary breast cancer patients were all biochemically and histochemically analyzed for both estrogen receptors and progesterone receptors. The dextran-coated charcoal (DCC) method measured the ER and PR as defined by Scatchard analysis, ligand competition experiments and target organ specificity. The ligands, estradiol-6-carboxymethyloxime-BSA-fluoresceine isothiocyanate and hydroxyprogesteronehemisuccinate-BSA-tetramethylrhodamine isothiocyanate, used for histochemistry, did not bind to either ER or PR and were mainly bound to the membrane fraction of isolated breast cancer cells. Fluorescence was not specifically inhibited by estrogens or progestogens. In addition, "estrogenic" always coincided with "progestogenic" fluorescence. The binding of the fluoresceine compounds to tissue slides depended on the large steroid hormone substitution on the bovine serum albumin molecule. Clinical parameters, known to be related to ER and PR did not correlate with the histochemical results. The observations indicated the impossibility of specific steroid receptor detection by the histochemical method. Therefore, up to the present, evaluation of hormone dependency and prognosis in human breast cancer cannot be based on this approach.

Published
1985
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5. Acquired ultrastructural abnormalities of bronchial cilia in recurrent airway infections and bronchiectases as compared with the findings in Kartagener syndrome: 15

Author

J.M. Lauweryns, Lucien Corbeel, F.J. Cornillie, Roger Eeckels, J. Van de Walle, and M Boel

Subjects
Pathology, medicine.medical_specialty, Cilium, Bronchiectases, Kartagener Syndrome, Anatomy, respiratory system, Biology, Dynein arms, Pediatrics, Perinatology and Child Health, Ultrastructure, medicine, Shortened outer dynein arms, In patient, Airway
Abstract

Electron microscopic studies revealing a lack of the dynein arms of the microtubular doublets of bronchial cilia and sperm tails suggest that Kartagener syndrome is a special manifestation of a hereditary disease, now referred to as the immotile cilia syndrome (Eliasson et al. N Engl J Med 297: 1, 1977). Anomalies of the bronchial cilia were observed in 5 patients with recurrent pulmonary infections. Patient 1 had Kartagener syndrome and an absence of the outer dynein arms in most ciliae, although occasional shortened and even normal arms were seen. Patient 2 and 3 had unilateral bronchiectases without family history of Kartagener syndrome. Serial studies of the bronchial epithelium showed a bilateral lack of the inner dynein arms and incomplete outer arms. These abnormalities persisted after recovery from acute pulmonary infection. In patients 4 and 5 with recurrent pulmonary infections without bronchiectases, many shortened outer dynein arms were observed, but these anomalies disappeared after recovery. In all 5 patients additional striking ciliary anomalies were found: megacilia, fused cilia, nude cilia and completely disorganized axonemes. These defects were more numerous in the patients without bronchiectases. Our observations suggest that anomalies of the bronchial ciliary microtubular system may not only be congenital but also acquired, and could be an important factor explaining some cases of repeated airway infection and bronchiectases.

Published
1980
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