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1. Correlation between biological responses in vitro and in vivo to Ca-doped sol-gel coatings assessed using proteomic analysis

Author: García-Arnáez, I., Romero-Gavilán, F., Cerqueira, A., Elortza, F., Azkargorta, M., Muñoz, F., Mata, M., de Llano, J.J. Martín, Suay, J., Gurruchaga, M., and Goñi, I.
Published: 2022
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2. Intrahepatic splenosis visualized on a [m99Tc]Tc-denatured erythrocyte scintigraphy

Author: S. Bondia Bescós, J.J. Martin Marcuartu, M.T. Bajén Lázaro, J. Mora Salvadó, A. Benítez Segura, and M. Cortés Romera
Subjects: General Engineering, General Earth and Planetary Sciences, General Environmental Science
Published: 2023

3. Frequency and Patterns of Brain Infarction in Patients With Embolic Stroke of Undetermined Source: NAVIGATE ESUS Trial

Author: Mukul Sharma, Eric E. Smith, Lesly A. Pearce, Ashkan Shoamanesh, Kanjana S. Perera, Shelagh B. Coutts, Dorte Damgaard, Sebastian F. Ameriso, Joung-Ho Rha, Boris Modrau, Byung-Woo Yoon, Marina Romano, Steven R. Messé, Jessica Barlinn, Johann Lambeck, Feryal Saad, Scott D. Berkowitz, Hardi Mundl, Stuart J. Connolly, Robert G. Hart, T.S. Field, G.J. Stotts, D.J. Gladstone, S.J. Phillips, A. Sharrief, C. Holmstedt, N. Vora, C. Wilson, B.M. Coull, A. de Havenon, L.A. Birnbaum, N. Patel, M.S. Hussain, D. Greer, S. Chen, S. Kittner, D. Mehta, T. Lowenkopf, R. Sawyer, V. Babikian, R. Zweifler, D.L. Tirschwell, C. Sila, C. Zhang, K-S. Hong, K. Oh, J.H. Heo, H-J. Bae, M.S. Park, J.S. Kim, C-S. Chung, B-C. Lee, G.P. Povedano, J.J. Martin, G.M. Bruera, L.V. Jure, J. Marti-Fabregas, I.C. Naranjo, J.M.R. Moreno, P.C. Portela, M. Gomis, J. Serena, H. Christensen, T. Christensen, S. Knecht, M. Endres, J. Berrouschot, F. Schlachetzki, S. Wunderlich, P. Kraft, P. Guyler, RC. Veltkamp, M. Burn, K. Rashed, M.J. Macleod, C. Canepa, J. Selvarajah, D. Hargroves, Y. Behnam, T.G. Robinson, L. Roveri, G. Lembo, D.S. Toni, V. Monzani, A. Cavallini, D. Popov, M. Friedrich, C. Minelli, C. Moro, R.J. Gagliardi, A. Bacellar, R. Mikulik, J. Eckstein, G. Panczel, N. Szegedi, and M.J. O’Donnell
Subjects: Brain Infarction, Male, medicine.medical_specialty, Internationality, Tobacco use, Cohort Studies, Magnetic resonance imaging, Double-Blind Method, Rivaroxaban, Internal medicine, medicine, Humans, In patient, cardiovascular diseases, Aged, Advanced and Specialized Nursing, Aspirin, medicine.diagnostic_test, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Middle Aged, Magnetic Resonance Imaging, Embolic stroke, Stroke, Intracranial Embolism, Brain infarction, Cardiology, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Factor Xa Inhibitors, medicine.drug
Abstract: Background and Purpose: The spectrum of brain infarction in patients with embolic stroke of undetermined source (ESUS) has not been well characterized. Our objective was to define the frequency and pattern of brain infarcts detected by magnetic resonance imaging (MRI) among patients with recent ESUS participating in a clinical trial. Methods: In the NAVIGATE ESUS trial (New Approach Rivaroxaban Inhibition of Factor Xa in a Global Trial Versus ASA to Prevent Embolism in Embolic Stroke of Undetermined Source), an MRI substudy was carried out at 87 sites in 15 countries. Participants underwent an MRI using a specified protocol near randomization. Images were interpreted centrally by those unaware of clinical characteristics. Results: Among the 918 substudy cohort participants, the mean age was 67 years and 60% were men with a median (interquartile range) of 64 (26–115) days between the qualifying ischemic stroke and MRI. On MRI, 855 (93%) had recent or chronic brain infarcts that were multiple in 646 (70%) and involved multiple arterial territories in 62% (401/646). Multiple brain infarcts were present in 68% (510/755) of those without a history of stroke or transient ischemic attack before the qualifying ESUS. Prior stroke/transient ischemic attack ( P 0 ( P P =0.01) were associated with multiple infarcts. Topographically, large and/or cortical infarcts were present in 89% (757/855) of patients with infarcts, while in 11% (98/855) infarcts were exclusively small and subcortical. Among those with multiple large and/or cortical infarcts, 57% (251/437) had one or more involving a different vascular territory from the qualifying ESUS. Conclusions: Most patients with ESUS, including those without prior clinical stroke or transient ischemic attack, had multiple large and/or cortical brain infarcts detected by MRI, reflecting a substantial burden of clinical stroke and covert brain infarction. Infarcts most frequently involved multiple vascular territories. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02313909.
Published: 2022

4. Análisis dinámico muscular y de la estructura interna del nervio periférico como biomarcadores para la esclerosis lateral amiotrófica: estudio piloto mediante ecografía

Author: C. López-Navarro, M. Serrano-Valero, E.M. Fages-Caravaca, J.J. Martínez-Payá, M.E. del Baño-Aledo, and J. Ríos-Díaz
Subjects: Amyotrophic lateral sclerosis, Neuromuscular diseases, Biomarkers, Ultrasonography, Skeletal muscle, Peripheric nerves, Neurology. Diseases of the nervous system, RC346-429
Abstract: Resumen: Introducción: El objetivo del trabajo fue conocer el comportamiento de los biomarcadores ecográficos de densidad fascicular y fuerza muscular en pacientes con esclerosis lateral amiotrófica (ELA). Métodos: Estudio piloto, observacional y transversal sobre 14 pacientes con ELA (mujeres; 28,6%) y 14 controles. Se tomaron ecografías bilaterales transversales en el abductor corto del pulgar (ACP) y tibial anterior (TA) con registro del grosor muscular (GM) en reposo, en contracción y diferencia de engrosamiento. En los nervios mediano, ciático y peroneo común se analizaron el área de sección transversal (AST), el número de fascículos (NF) y la densidad fascicular (DF). Los análisis se realizaron anidados por lateralidad. Resultados: El acuerdo intra-interobservador en los recuentos de fascículos fue muy bueno con un error mínimo detectable
Published: 2024
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5. Dynamic analysis of muscles and the internal structure of the peripheral nerve as biomarkers of amyotrophic lateral sclerosis: A pilot study with ultrasound imaging

Author: C. López-Navarro, M. Serrano-Valero, E.M. Fages-Caravaca, J.J. Martínez-Payá, M.E. del Baño-Aledo, and J. Ríos-Díaz
Subjects: Esclerosis lateral amiotrófica, Enfermedades neuromusculares, Biomarcadores, Ultrasonografía, Músculo esquelético, Nervios periféricos, Neurology. Diseases of the nervous system, RC346-429
Abstract: Introduction: The aim of this study was to determine the behaviour of ultrasound biomarkers of fascicle density and muscle strength in patients with amyotrophic lateral sclerosis (ALS). Methods: We conducted an observational, cross-sectional pilot study of 14 patients with ALS (28.6% women) and 14 controls. Bilateral cross-sectional ultrasound scans were performed in the abductor pollicis brevis (APB) and tibialis anterior (TA) muscles, with recording of muscle thickness (MT) at rest and in contraction, and the difference in thickness. In the median, sciatic, and common peroneal nerves, we analysed the cross-sectional area (CSA), number of fascicles (NF) and fascicle density (FD). Analyses were nested by laterality. Results: Intra- and interrater agreement regarding NF was very good, with a minimum detectable error of
Published: 2024
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6. Photodissociation of S2 (X3Σg–, a1Δg, and b1Σg+) in the 320–205 nm Region

Author: Zahid Farooq, Patrick J.J. Martin, Colin M. Western, David H. Parker, and Zhong-Fa Sun
Subjects: 010304 chemical physics, Chemistry, Photodissociation, Ab initio, 010402 general chemistry, 7. Clean energy, 01 natural sciences, Quantum chemistry, Molecular physics, Potential energy, Spectral line, Article, 0104 chemical sciences, Photoexcitation, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, Excited state, 0103 physical sciences, Molecule, Physical and Theoretical Chemistry
Abstract: Photodissociation of vibrationally and electronically excited sulfur dimer molecules (S2) has been studied in a combined experimental and computational quantum chemistry study in order to characterize bound-continuum transitions. Ab initio quantum chemistry calculations are carried out to predict the potential energy curves, spin-orbit coupling, transition moments, and bound-continuum spectra of S2 for comparison with the experimental data. The experiment uses velocity map imaging to measure S-atom production following S2 photoexcitation in the ultraviolet region (320-205 nm). A pulsed electric discharge in H2S produces ground-state S2 X3ςg -(v = 0-15) as well as electronically excited singlet sulfur and b1ςg +(v = 0, 1), and evidence is presented for the production and photodissociation of S2 a1Δg. In a previous paper, we reported threshold photodissociation of S2X3ςg -(v = 0) in the 282-266 nm region. In the present study, S(3PJ) fine structure branching and angular distributions for photodissociation of S2 (X3ςg -(v = 0), a1Δg and b1ςg +) via the B″3IIu, B3ςu - and 11IIu excited states are reported. In addition, photodissociation of the X3ςg -(v = 0) state of S2 to the second dissociation limit producing S(3P2) + S(1D) is characterized. The present results on S2 photodynamics are compared to those of the well-studied electronically isovalent O2 molecule.
Published: 2019

7. Stroke

Author: Christina Jern, Martin Stenman, Tobias Brandt, Sandra Freitag-Wolf, Braxton D. Mitchell, Manja Kloss, Didier Leys, Jonathan Rosand, Stefan T. Engelter, Michael Krawczak, Steven J. Kittner, Vincent Thijs, Giacomo Giacalone, Daniel Woo, J.J. Martin, Jordi Jimenez-Conde, Philip Ginsbach, Emmanuel Touzé, Armin J. Grau, Elisabetta Del Zotto, Tiina M. Metso, Philipp Erhart, Eyad Hayani, Dorothea Pfeiffer, Christoph Lichy, I. Werner, Valeria Caso, Bowang Chen, Antti J. Metso, Caspar Grond-Ginsbach, Arne Lindgren, Shérine Abboud, Anna Bersano, Natalia S. Rost, Kristina Schlicht, Jane Maguire, John W. Cole, Robin Lemmens, Alessandro Pezzini, Jin-Moo Lee, Philippe Lyrer, Steve Bevan, Christopher Traenka, Stéphanie Debette, Turgut Tatlisumak, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: DNA copy number variations, Neurology, Gene Dosage, Logistic regression, Severity of Illness Index, Brain Ischemia, 0302 clinical medicine, Modified Rankin Scale, Gene Duplication, Chromosomes, Human, genetics, Stroke, RISK, 0303 health sciences, Middle Aged, stroke, VINTAGE, Medical genetics, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, Genotype, Clinical Neurology, Subgroup analysis, COPY-NUMBER VARIATION, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Genetic imbalance, Internal medicine, OHNOLOGS, medicine, Humans, Aged, 030304 developmental biology, Advanced and Specialized Nursing, Science & Technology, Neurology & Neurosurgery, business.industry, GENOME-WIDE, Recovery of Function, Odds ratio, medicine.disease, Peripheral Vascular Disease, Cardiovascular System & Cardiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurosciences & Neurology, prognosis, Neurology (clinical), business, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract: Background and Purpose— We sought to explore the effect of genetic imbalance on functional outcome after ischemic stroke (IS). Methods— Copy number variation was identified in high-density single-nucleotide polymorphism microarray data of IS patients from the CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) and SiGN (Stroke Genetics Network)/GISCOME (Genetics of Ischaemic Stroke Functional Outcome) networks. Genetic imbalance, defined as total number of protein-coding genes affected by copy number variations in an individual, was compared between patients with favorable (modified Rankin Scale score of 0–2) and unfavorable (modified Rankin Scale score of ≥3) outcome after 3 months. Subgroup analyses were confined to patients with imbalance affecting ohnologs—a class of dose-sensitive genes, or to those with imbalance not affecting ohnologs. The association of imbalance with outcome was analyzed by logistic regression analysis, adjusted for age, sex, stroke subtype, stroke severity, and ancestry. Results— The study sample comprised 816 CADISP patients (age 44.2±10.3 years) and 2498 SiGN/GISCOME patients (age 67.7±14.2 years). Outcome was unfavorable in 122 CADISP and 889 SiGN/GISCOME patients. Multivariate logistic regression analysis revealed that increased genetic imbalance was associated with less favorable outcome in both samples (CADISP: P =0.0007; odds ratio=0.89; 95% CI, 0.82–0.95 and SiGN/GISCOME: P =0.0036; odds ratio=0.94; 95% CI, 0.91–0.98). The association was independent of age, sex, stroke severity on admission, stroke subtype, and ancestry. On subgroup analysis, imbalance affecting ohnologs was associated with outcome (CADISP: odds ratio=0.88; 95% CI, 0.80–0.95 and SiGN/GISCOME: odds ratio=0.93; 95% CI, 0.89–0.98) whereas imbalance without ohnologs lacked such an association. Conclusions— Increased genetic imbalance was associated with poorer functional outcome after IS in both study populations. Subgroup analysis revealed that this association was driven by presence of ohnologs in the respective copy number variations, suggesting a causal role of the deleterious effects of genetic imbalance.
Published: 2019

8. 394P Preliminary tolerance analysis of adjuvant chemotherapy in older patients after resection of stage III colon adenocarcinoma from PRODIGE 34-FFCD 1402-ADAGE randomized phase III trial

Author: Thomas Aparicio, Sandrine Hiret, P.L. Etienne, R. Desgrippes, V. Lebrun-Ly, Y. Rinaldi, F. Hocine, L. Mineur, M. Pauwels, M. Van den Eynde, J.J. Martin, J. Cretin, Jérôme Desramé, Eric Terrebonne, L. Cany, Anthony Turpin, Emilie Barbier, Claire Falandry, O. Bouche, L. Mosser, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service d'oncologie médicale, and UCL - (SLuc) Service d'hépato-gastro-entérologie
Subjects: Oncology, medicine.medical_specialty, business.industry, Adjuvant chemotherapy, Hematology, Resection, Older patients, Internal medicine, Medicine, Colon adenocarcinoma, Stage (cooking), business
Abstract: Background Colon adenocarcinoma occurs mainly in older patients (pts). Oxaliplatin based adjuvant chemotherapy has demonstrated an improvement on disease-free survival (DFS) after a stage III colon cancer resection in young pts. Nevertheless, the benefit of adjuvant chemotherapy is matter of debate in old pts. Methods The purpose of ADAGE trial is to compare the DFS obtain with oxaliplatin combined with fluoropyrimidine (F) to F alone in fit pts over 70 years (group 1) and F to observation in frail pts (group 2) after resection of a stage III colon cancer. We here report a preliminary tolerance analysis on 50% of the first pts enrolled in the study. Results The analysis was performed on 491 pts (378 in group 1 and 113 in group 2). Main pts characteristics were respectively for the group 1 and 2: male in 57% and 50%, median age of 76 and 83 years, ECOG=0 in 59% and 29%, abnormal IADL in 23% and 62%, no caregiver in 26% and 28%, fall ≤6 months in 9% and 14%, depression possible 28% and 40%, fail of one-leg balance in 20% and 59%, impaired cognition in 21% and 38%, G8 score
Published: 2021

9. Serum Amyloid A Stimulates Vascular and Renal Dysfunction in Apolipoprotein E-Deficient Mice Fed a Normal Chow Diet

Author: Belal Chami, Farjaneh Hossain, Thomas W. Hambly, Xiaoping Cai, Roshanak Aran, Genevieve Fong, Abigail Vellajo, Nathan J.J Martin, XiaoSuo Wang, Joanne M. Dennis, Arpeeta Sharma, Waled A. Shihata, Jaye P. F. Chin-Dusting, Judy B. de Haan, Alexandra Sharland, Carolyn L. Geczy, Ben Freedman, and Paul K. Witting
Subjects: Male, 0301 basic medicine, Apolipoprotein E, Apolipoprotein B, Kidney Function Tests, Mice, chemistry.chemical_compound, 0302 clinical medicine, endothelial function, acute-phase protein, Immunology and Allergy, Medicine, Endothelial dysfunction, Aorta, Original Research, Mice, Knockout, Kidney, biology, Acute-phase protein, Immunohistochemistry, Lipids, medicine.anatomical_structure, Cytokines, Kidney Diseases, Disease Susceptibility, Inflammation Mediators, medicine.symptom, lcsh:Immunologic diseases. Allergy, medicine.medical_specialty, Immunology, Inflammation, 03 medical and health sciences, Apolipoproteins E, nitric oxide, renal dysfunction, Internal medicine, Animals, Serum amyloid A, Cyclic guanosine monophosphate, Peroxidase, Serum Amyloid A Protein, business.industry, Macrophages, Endothelial Cells, medicine.disease, Disease Models, Animal, 030104 developmental biology, Endocrinology, chemistry, inflammation, biology.protein, Blood Vessels, lcsh:RC581-607, business, Biomarkers, 030215 immunology
Abstract: Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in apolipoprotein E-deficient (ApoE−/−) mice. Male ApoE−/− mice received vehicle (control), low-level lipopolysaccharide (LPS), or recombinant human SAA by i.p. injection every third day for 2 weeks. Heart, aorta and kidney were harvested between 3 days and 18 weeks after treatment. SAA administration increased vascular cell adhesion molecule (VCAM)-1 expression and circulating monocyte chemotactic protein (MCP)-1 and decreased aortic cyclic guanosine monophosphate (cGMP), consistent with SAA inhibiting nitric oxide bioactivity. In addition, binding of labeled leukocytes to excised aorta increased as monitored using an ex vivo leukocyte adhesion assay. Renal injury was evident 4 weeks after commencement of SAA treatment, manifesting as increased plasma urea, urinary protein, oxidized lipids, urinary kidney injury molecule (KIM)-1 and multiple cytokines and chemokines in kidney tissue, relative to controls. Phosphorylation of nuclear-factor-kappa-beta (NFκB-p-P65), tissue factor (TF), and macrophage recruitment increased in kidneys from ApoE−/− mice 4 weeks after SAA treatment, confirming that SAA elicited a pro-inflammatory and pro-thrombotic phenotype. These data indicate that SAA impairs endothelial and renal function in ApoE−/− mice in the absence of a high-fat diet.
Published: 2019

10. A systematic literature review and network meta-analysis of treatments for patients with untreated multiple myeloma not eligible for stem cell transplantation

Author: Weisel, K. Doyen, C. Dimopoulos, M. Yee, A. Lahuerta, J.J. Martin, A. Travers, K. Druyts, E. Toor, K. Abildgaard, N. Lu, J. Van Droogenbroeck, J. Geraldes, C. Petrini, M. Voillat, L. Voog, E. Facon, T.
Abstract: In newly diagnosed multiple myeloma (MM), patients ineligible for front-line autologous stem cell transplantation (ASCT), melphalan and prednisone (MP) with thalidomide (MPT) or bortezomib (VMP) are standard first-line therapeutic options. Despite new treatment regimens incorporating bortezomib or lenalidomide, MM remains incurable. The FIRST study demonstrated significant improvement in progression-free survival (PFS) and overall survival (OS) for the combination of lenalidomide and low-dose dexamethasone (Rd) until progression vs. MPT in transplant-ineligible ndMM patients. However, to date no head-to-head randomized controlled trials (RCTs) have compared Rd or MPT versus VMP. We conducted a network meta-analysis using RCTs identified through a systematic literature review to evaluate the relative efficacy of Rd versus other regimens on survival endpoints in previously untreated MM patients ineligible for ASCT. In this analysis, Rd was associated with a significant PFS and survival advantage versus other first-line treatments (VMP, MPT, MP), challenging the role of alkylators in this setting. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Published: 2017

11. QFT Templates for Plants With a High Number of Uncertainty Parameters

Author: J.J. Martin-Romero and A. Martin-Romero
Subjects: Mathematical optimization, Template, Quantitative feedback theory, Control and Systems Engineering, Computation, Uncertain systems, Electrical and Electronic Engineering, Robust control, Parametric equation, Computer Science Applications, Analytic function, Mathematics
Abstract: When uncertainty is given in parametric form, the QFT templates computation requires time if the number of parameters is high. The latest methods do not solve the problem efficiently. The present note shows a new way to calculate templates by means of analytic functions. The discrete template is replaced by an analytic template, so operations are done with functions, not with points. In such a way, the computation time is reduced and the results can be used to solve other problems such as bounds computation
Published: 2007

12. A Theoretical-Experimental Study on the Structure and Activity of Certain Quinolones and the Interaction of Their C<scp>u</scp>(II)-Complexes on a DNA Model

Author: Juvencio Robles, Leonardo Alvarez-Valtierra, Guillermo Mendoza-Díaz, J.J. Martin-Polo, and L. Hinojosa
Subjects: Pharmacology, Quenching (fluorescence), Intercalation (chemistry), Reactive intermediate, Stacking, Electronic structure, Toxicology, Adduct, Inorganic Chemistry, Rhodamine 6G, Crystallography, chemistry.chemical_compound, chemistry, Drug Discovery, A-DNA, Research Article
Abstract: Theoretical electronic Structure methods have been employed to study the structure and activity of certain (free) quinolones and the interaction of their Cu(II)-complexes on a DNA model (Rhodamine 6G (rhod)). As a manner of assessing the generated geometries, the nalidixic acid geometrical parameters obtained were tested against the crystallographic ones and it was found that the average error in the calculated geometries is small. The present study allows us to (1) Rationalize the observed differences in antibiotic activities through their electronic hardnesses. (2) Suggest a plausible mechanism of action for these drugs through formation of a reactive intermediate (or carrier) which would consist of a quinolone anion coordinated to an adequate metal center (Cu(II) in this study). (3) We find that, through this model of DNA (modeled with rhod) the interaction seems to be mediated by an effective π-π stacking. (4) Finally, an in vitro experiment was designed so that the intercalation process in DNA could be experimentally modeled as well. The quenching of the rhod fluorescence is proportional to the strength of the Cu(II)-complex-rhod interaction and therefore provides a quantitative measurement of the “intercalating” capacity of the quinolones and their copper complexes. These results agree well with the theoretical total adduct formation energies.
Published: 2000

13. Antigen Retrieval in Prion Protein Immunohistochemistry

Author: B Van Everbroeck, J.J. Martin, Patrick Cras, and Ph. Pals
Subjects: 0301 basic medicine, Pathology, medicine.medical_specialty, Hot Temperature, Histology, Formates, Prions, Formic acid, Encephalopathy, Picric acid, Creutzfeldt-Jakob Syndrome, Epitope, Epitopes, 03 medical and health sciences, chemistry.chemical_compound, Picrates, Antigen, Reference Values, medicine, Humans, Microwaves, 030102 biochemistry & molecular biology, Histological Techniques, Brain, medicine.disease, Immunohistochemistry, Molecular biology, 030104 developmental biology, Antigen retrieval, chemistry, Indicators and Reagents, Anatomy, Immunostaining
Abstract: SUMMARY Transmissible spongiform encephalopathies are a group of neurodegenerative diseases occurring in both humans and animals and are most likely caused by prions. Neuropathological confirmation of the clinical diagnosis has been a problem because of the difficulty in epitope retrieval from formalin-fixed, paraffin-embedded brain specimens. Many different protocols for the detection of prions in brain tissue have been used. Thus far, picric and/or formic acid, steam autoclaving at 121C of sections, microwave treatment, and 4 M guanidine thiocyanate treatment have been suggested. The objective of our experiment was to obtain the standard pretreatment(s) resulting in optimal immunostaining. In the experiment, successive tissue slides of brain specimens of several Creutzfeldt‐Jakob disease and control patients were stained using different combinations of pretreatments. Using densitometric analysis, several well-defined locations per section were examined and prion immunostaining was quantified. The results showed that autoclaving is necessary for antigen retrieval and cannot be substituted by microwave treatment. The best results were obtained when the following combination was used in the specified order: 15 min saturated picric acid, 10 min steam autoclaving at 121C, 5 min 88% formic acid, and 2 hr 4 M guanidine thiocyanate at 4C. (J Histochem Cytochem 47:1465‐1470, 1999)
Published: 1999

14. A new combined Bodian-Luxol technique for staining unmyelinated axons in semithin, resin-embedded peripheral nerves: a comparison with electron microscopy

Author: Arnaud Fumal, Manuel Deprez, J.J. Martin, Michel Reznik, and Chantal Ceuterick-de Groote
Subjects: Male, Nervous system, Silver Staining, Pathology, medicine.medical_specialty, Indoles, Unmyelinated nerve fiber, Population, Axonal loss, Cell Count, Biology, Nerve Fibers, Myelinated, Pathology and Forensic Medicine, law.invention, Cellular and Molecular Neuroscience, Nerve Fibers, law, medicine, Humans, Peripheral Nerves, Axon, Coloring Agents, education, Skin, education.field_of_study, Tissue Embedding, Anatomy, Middle Aged, Axons, Staining, Microscopy, Electron, medicine.anatomical_structure, Ultrastructure, Neurology (clinical), Electron microscope, Resins, Plant
Abstract: Quantitation of unmyelinated fibers (UF) in peripheral nerves has classically relied upon ultrastructural morphometry. Because this method is time-consuming, it is not typically performed in routine analysis of nerve biopsies. We applied the Bodian-Luxol technique to detect unmyelinated axons by light microscopy on semithin sections from resin-embedded nerve tissue. Estimates were compared to ultrastructural counts. The staining appeared highly specific for axons. Excellent correlation was found between optic densities and the population of UF larger than 0.5 microm. The smallest profiles detected by light microscopy had a diameter close to 0.6 microm. This new technique is not a substitute for ultrastructural quantitative morphometry of UF, as very small unmyelinated axons, especially regenerating ones, can not be reliably visualized. However, it provides a valuable light microscopic method for evaluating axonal loss among UF.
Published: 1999

15. Mutation analysis of the nerve specific promoter of the peripheral myelin protein 22 gene in CMT1 disease and HNPP

Author: C. Van Broeckhoven, P. De Jonghe, J.J. Martin, E. De Vriendt, Pragna Patel, and Eva Nelis
Subjects: Male, DNA Mutational Analysis, Molecular Sequence Data, Biology, Polymerase Chain Reaction, Myelin, Exon, Charcot-Marie-Tooth Disease, Peripheral myelin protein 22, Gene duplication, Genetics, medicine, Humans, Coding region, Promoter Regions, Genetic, Gene, Polymorphism, Single-Stranded Conformational, Genetics (clinical), DNA Primers, Base Sequence, Exons, medicine.disease, Pedigree, medicine.anatomical_structure, Peripheral neuropathy, Mutation, Mutation testing, Female, Hereditary Sensory and Motor Neuropathy, Myelin Proteins, Research Article
Abstract: We analysed the nerve specific promoter of the peripheral myelin protein 22 gene (PMP22) in a set of 15 unrelated patients with Charcot-Marie-Tooth type 1 disease (CMT1) and 16 unrelated patients with hereditary neuropathy with liability to pressure palsies (HNPP). In these patients no duplication/deletion nor a mutation in the coding region of the CMT1/ HNPP genes was detected. In one autosomal dominant CMT1 patient, we identified a base change in the non-coding exon 1A of PMP22 which, however, did not cosegregate with the disease in the family. This study indicates that mutations in the nerve specific PMP22 promoter and 5' untranslated exon will not be a common genetic cause of CMT1A and HNPP.
Published: 1998

16. Pathological complete remission with preoperative hyperfractionated chemoradiation v/s standard chemoradiation

Author: C. Borque Molinos, J.J. Martin Ortega, C. Fuentes Sanchez, A.N.A. Armijo Mallorquín, M. García Morales, M. Espineira Yanes, J. Pena Vivas, S. Villamil Montufar, J. C. Martínez Cedres, and R. Hernandez Gonzalez
Subjects: medicine.medical_specialty, Cancer Research, Oncology, business.industry, Radiology Nuclear Medicine and imaging, Medicine, Pathological Complete Remission, Radiology, Nuclear Medicine and imaging, Radiology, business
Published: 2013
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17. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author: H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. J. Broere, D. Chavdarov, J. P. Willmer, C. H. Hawkes, Th. Naegele, E. Ellie, E. Dartigues, M. J. Guardiola, S. Hesse, Z. Levic, Marco Rovaris, P. Saugeir-Veber, B. A. Yaqub, H. F. Durwen, R. Larumbe, J. Ballabrina, M. Sendtner, J. Röther, M. Horstink, C. Kluglein, M.P. Montesi, H. Apaydin, J. Montoya, E. Waubant, Ch. Verellen-Dunoulin, A. Nicolai, J. Lopez-Delval, R. Lemon, G. Cantinho, E. Granieri, A. Zeviani, Wolfgang H. Oertel, U. Ficola, V. Di Piero, V. Fragola, K. Sabev, M. V. Guitera, I. Turki, F. Bolgert, P. Ingrand, J. M. Gobernado, L. M. E. Grimaldi, S. Baybas, B. Eymard, Y. Rolland, Y. Robitaille, Ta. Pampols, P. J. Koehler, A. Carroacedo, J. Vilchez, S. Di Vittorio, I. R. Rise, T. Nagy, M. Kuffner, E. Palazzini, A. Ott, J. Pruim, T. X. Arbizu, E. Manetti, C. Cervera, S. Felber, G. Gursoy, J. Scholz, G. A. Buscaino, M. S. Chen, A. Pascual, J. Hazan, J. U. Gajda, J. G. Cea, G. Bottini, G. Damalik, F. Le Doze, G. Bonaldi, J. M. Hew, C. Messina, A. M. Kennedy, J. M. Carney, N. M. F. Murray, M. Parent, M. Koepp, V. Dimova, D. De Leo, K. Jellinger, G. Salemi, S. Mientus, M. L. Hansen, F. Mazzucchelli, J. Vieth, M. Mauri, E. Bartels, L. Johannsen, C. Humphreys, J. Emile, D. N. Landon, E. Kansu, R. Sanchez-Pernaute, Rsj Frackowiak, M. Gonzalez Torres, L. Oller, C. Machedo, J. Kother, M. Billiard, H. Durak, T. Schindler, A. Frank, A. Uncini, A. Sbriccoli, C. Farinas, D. W. Paty, N. Fast, A. T. Zangaladze, A. Kerkhofs, J. M. Pino Garcia, I. De la Fuente, B. Marini, L. Gomez, I. Rubio, Alessandra Bardoni, C. Brodie, P. Acin, U. Sliwka, S. A. Hawkins, S. Tardieu, F. Vitullo, J. M. Pereira Monteino, R. Gagliardi, T. Jezewski, A. Cano, T. Lempert, F. Abad Alegria, G. Rotondo, D. Ince, C. Martinez Parra, Y. Huang, H. Luders, Y. Steinvil, F. G. A. Van Der Meche, R. Bianchi, A. Sanchez, T. Sevilla, J. M. Ketelslegers, A. Domzal-Stryga, M. Pandolfo, M. O. Josse, K. W. Neff, I. Blanco, G. W. Bruyn, O. W. Witte, J. L. Thibault, G. Andersen, J. Pariset, A. Marcone, R. J. M. Lane, A. Hofman, M. Verin, T. Matilla, P. Bedoucha, J. Roche, M. Lai, M. Collard, A. Ugarte, F. Gallecho, D. Silbersweig, C. Kennard, J. P. Azulay, T. W. Ho, P. L. I. Dellemijn, R. Girardello, F. Baas, B. Voss, F. Rozenberg, E. M. Brocker, V. Stanev, A. A. J. Soeterboek, A. Marra, A. Rey, E. Ertem, M. Sawradewicz-Rybak, J. De Keyser, P. Cavallari, F. Proust, Y. Chevalier, H. C. Hansen, D. Leys, C. A. Davie, K. Hoang-Xuan, C. Bairati, H. van Crevel, Thomas T. Warner, B. Bompais, A. Dobbeleir, T Campbell, C. Macko, C. J. M. Klijn, M. Dussallant, T. P. Berlit, W. Rozenbaum, M. J. van den Bent, W. A. Rocca, M. Muller, H. Hundemer, U. Zifko, M. Campera, F. Drislane, D. Ranoux, T. M. Kloss, Anil Kumar, I. Ruolt, C. Bargnani, B. Marescau, N. A. Losseff, S. Notermans, B. Kint, E. T. Burke, C. Aykut, J. Matias Guiu, P. Maquet, T. Drogendijk, M. Leone, K. von Ammon, M. Pepeliarska, C. Prados, L. DiGiamberardino, T. Logtenberg, G. Lenoir, I. Castaldo, Damhaut, M. Radionova, G. Sirabian, R. Navon, Giovanni Antonini, K. Al Moutaery, E. Chamas, R. Schönhuber, M. Giannini, B. Debilly, I. Labatut, H. Henon, J. A. Egido, M. Baudrimont, J. N. Lorenzo, J. E. C. Bromberg, R. Antonacci, J. J. Vilchez, T. Moulin, B. Rautenstrauss, Giovanni Meola, J. Noth, S Mammi, P. Laforet, F. Lopez, C. Gehring, S. Bort, G. Rancurel, D. Decamps, S. Kostadinova, Y. Shapira, B. Neundoerfer, D. Chavrot, M. Solimena, J. P. Salier, W. Deberdt, R. Hoff-Jörgensen, A. Messina, S. Meairs, G. Rosoklija, E. Nelis, I. Bertran, C. Ertekin, J. Lohmeyer, Mitermayer Galvao dos Reis, L. Calo, E. Maccagnano, A. P. Hays, J. Verlooy, M. G. Forno, T. Blanco, L. Bail, Gabriella Silvestri, J. Montero, F. Bertrand, R. T. Ghnassia, C. Besses, T. Sereghy, F. Shalit, G. Bogliun, S. Braghi, St. Baykouchev, C. Franke, A. Lasa, L. C. Archard, J. Kriebel, S. Shaunak, M. Nocito, Alexander Tsiskaridze, E. Manfredini, T. Seigal, David G. Gadian, M. Barlas, J. D. Degos, C. Seeber, J. Caemert, J. L. Mas, R. B. Pepinsky, M. G. D'Angelo, N. Baumann, S. Yorifuji, H. P. Endtz, M. A. Cassatella, R. A. C. Hughes, V. Golzi, A. Bittencourt, A. Ferreira, M. Sanson, C. Alper, M. Vermeulen, M. A. A. van Walderveen, E. Alexiou, C. H. Lucas, M. Fiorelli, Y. N. Debbink, R. Gil, S. Congia, T. Banerjee, J. M. Bouchard, A. N. Pinto, A. Ceballos-Baumann, G. Grollier, P. I. M. Schmitz, M. D. Catata, N. Lahat, N. S. Rao, P. Papathanasopoulos, J. Valls-Solé, D. Claus, G. Schroter, A. Castro, C. Videbaek, R. Martinez Dreke, A. D. Platts, M. Hermesl, A. C. PeÇanha-Martins, M. Cardoso Silva, P. Masnou, M. J. A. Tanner, Ch. Confavreux, B. Mishu, H. Rasmussen, L. Valenciano, Carlo Pozzilli, S. W. Li, V. Salzman, Y. Vashtang, Massimo Franceschi, M. Severo, G. Deuschl, S. Setien, G. Mariani, A. Protti, J. Castillo, M. J. B. Taphoorn, M. Frontali, I. Milonas, D. Decoq, J. A. Navarro, S. Castellvi-Pel, C. Ertikin, M. Urtasun, Y. Lajat, B. E. Kendall, E. Verdu, B. Gueguen, E. Boisen, R. Couderc, A Danek, JM Stevens, F. Nicoli, L. Feltri, M. L. Vazquez-Andre, J. A. Morgan-Hughes, L. D'Angelo, F. Y. Liew, L. F. Pascual, J. Patrignani Ochoa, Vittorio Martinelli, J. Cophignon, L. Zhang, S. Martin, J. F. Meder, H. C. Buschmann, L. Bertin, J. van Gijn, A. Barreiro, A. Cools, C. Leon, A. Berod, E. A. Anllo, E. Zanette, L. Petrov, R. Barona, B. Gallicchio, P. J. Cozzone, N. Diederich, G. Cancel, L. Schelosky, P. Orizaola, K. Yulug, S. Ozer, Valeria A. Sansone, B. Guiraud-Chaumeil, K. Voigt, P. Labauge, M. Eoli, J. Zhu, J. Aguirre, M. Ferrarini, B. Zyluk, E. Planas, A. Cadilha, C. Tortorella, H. Bismuth, C. E. Counsell, A. Laun, A. Ferlini, Rio J. Montalban, N. Biary, L. Becker, M. Fardeau, M. Poloni, V. M. S. de Bruin, C. Fornada, J. Barros, E. Ganzmann, E. Touze, D. Wallach, J. Peila, H. Fujimura, M. T. Iba-Zizen, G. Macchi, C. Villoslada, R. Gouider, Ph. Rondepierre, P. Grummich, P. Chiodi, C. Conte, M. Michels, P. Annunziata, G. Semana, C. Sommer, J. Vajsar, D. Zekin, J. Kulisevsky, David G. Munoz, B. Jacotot, M. Magoni, A. Luxen, T. Garcia-Silva, S. Di Cesare, Christophe Tzourio, M. Gomori, I. Picomell, L. Santoro, F. Villa, Giovanni Pennisi, T. Ribalta, J. M. Molto, L. Marzorati, P. Loiseau, F. Gemignani, A. Gironell, J. Wissel, A. Prusinski, F. Cailloux, P. Villanueva-Hemandez, P. Cozzone, T. Del Ser, J. Sans-Sabrafen, M. Zappia, P. W. A. Willems, G. Tchernia, D. Gardeur, R. Bauer, F. Palomo, H. Metz, S. Lamoureux, C. Chastang, I. Reinhard, A. Goldfarb, S. Harder, Jordi Río, C. Ozkara, E. Tekinsoy, P. Vontobell, J. De Recondo, M. Rabasa, L. Lacomblez, F. Boon, Dgt Thomas, V. Palma, Renato Mantegazza, A. Dervis, M. Nueckel, B. YalÇinerner, I. Duran, G. Dalla Volta, A. Zubimendi, J. Pinheiro, A. Marbini, Xavier Montalban, H. Wekerle, X. Pereira Monteino, F. Crespo, F. Koskas, N. Battistini, C. Ruiz, H. Offner, J. de Pommery, P. Kanovsky, J. Y. Barnett, J. Pardo, G. Tomei, R. Rene, H. M. Lokhorst, P. Thajeb, H. Bilgin, D. McGehee, R. Fahsold, L. Morgante, Katie Sidle, C. Delwaide, M. N. Diaye, P. H. Rice, A. Creange, C. Sabev, K. Stephan, K. WeilBenborn, G. Magnani, L. Grymonprez, F. Cardellach, M. Kaps, N. G. Meco, F. Vega, V. Bonifati, A. Desomer, M. Baldy-Moulinier, G. Kvale, F. J. Authier, B. Yegen, T. Ho, J. M. Rozet, E. A. Cabanis, L. Bruce, L. Ambrosoli, M. A. Petrella, M. Hernandez, P. Timmings, H. B. van der Worp, F. Mahieux, A. Urbano-Marquez, D. A. Krendel, A. A. Garcia, R. Divari, R. Michalowicz, M. R. Piedmonte, M. Bondavalli, M. Zanca, P. F. Ippel, Onofre Combarros, B. Tavitian, E. Hirsch, I. Anastasopoulos, A. Roses, A. Köhler, P. Vienna, V. Timmerman, P. Sergi, F. Cornelio, A. Di Pasquale, R. Verleger, S. Castellvirel, J. Proano, B. van Moll, F. Rubio, W. Hacke, I. Lavenu, L. Zetta, M. W. Tas, N. Bittmann, M. Bonamini, O. R. Hommes, V. Dousset, N. Afsar, S. Belal, R. R. Myers, J. Goes, Giuseppe Vita, E. Clementi, V. G. Karepov, M. Jueptner, A Vincent, P. Emmrich, Th. Heb, A. Caballo, J. Gallego, T. Mokrusch, C. Perla, L. Gebuhrer, O. Titlbach, Alessandro Prelle, A. Czlonkowska, M. Russo, D. Hadjiev, T. S. Chkhikvishvili, M. Oehlschlager, G. Becker, I. Günther, E. N. Stenager, J. Garcia Agundez, J. Casademont, J. Batlle, S. Podobnik-Sarkanji, C. Alonso-Villaverde, B. Delaguillaume, B. Genc, B. Mazoyer, A. Rodriguez-Al-barino, Ch. Hilger, B. Ferrero, R. Price, W. Grisold, L. Fuhry, D. Oulbani, D. Ewing, A. Petkov, W. Walther, A. Gokyigit, John Newsom-Davis, J. Tayot, D. Seliak, G. Pelliccioni, D. Campagne, K. Kessler, F. Boureau, D. Perani, J. P. N'Guyen, N. Tchalucova, B. A. Antin-Ozerkis, C. Lacroix, B. D. Aronovich, I. H. Jenkins, E. A. dos Reis, M. Hortells, H. M. Meinck, H. Ch. Buschmann, S. C. J. M. Jacobs, T. Wetter, P. Creissard, N. Martinez, J. Weidenfeldl, H. J. Sturenburg, G. Damlacik, V. Gracia, J. C. Turpin, A. Pou-Serradell, J. P. Vincent, T. Gagoshidze, U. Ozkutlu, M. McLeod, K. Siegfried, I. Tchaoussoglou, J. Hildebrand, S. Kowalska, M. C. Picot, G. Galardin, L. Crevits, F. Andreetta, S. Larumbe-Lobalde, G. de la Sierra, J. C. Alvarez-Cermeno, R. J. Seitz, P. L. Oey, L. Ptacek, A. M. J. Paans, A. Wirrwar, A. Schmied, J. Uilchez, H. Tounsi, D. Hipola, V. Avoledo, Y. Hirata, P. Vermersch, T. M. Aisonobe, J. Valls-SoIè, H. Staunton, J. Dichgans, R. Karabudak, I. Dones, G. Porta, E. Janssens, Maria Martinez, J. M. Fernandez-Real, R. Villagra, Y. Yoshino, C. Kabus, K. Schimrigk, I. Girard-Buttaz, F. Piccoli, F. Aichner, P. Zuchegna, S. M. Al Deeb, F. Bono, N. Busquets, A. Jobert, Patrizia Ciscato, M. Martin, L. Polman, S. Darbra, V. Le Cam-Duchez, F. Baldissera, B. Baykan-Kurt, D. Guez, M. Bratoeva, H. Matsui, M. Mila, H. Perron, L. Bjorge, G. Husby, Steven T. DeKosky, D. R. Cornblath, J. M. Gabriel, J. J. Poza, Y. Wu, A. Toscano, R. P. Kleyweg, J. Kuhnen, S. O. Confort-Gouny, A. Barcelo, A. M. Conti, C. Fiol, C. Steichen-Wiehn, J. Rodes, M. Cavenaile, C. Vedeler, M. Drlicek, C. Argentino, M. L. Peris, A. Cervello, A. Z. GinaÏ, S. Yancheva, D. Passingham, S. Aoba, D. L. Lopez, T. Rechlin, K. Sonka, L. Grazzi, V. Folnegovic-Smalc, Maurizio Moggio, S. Rivaud, F. G. I. Jennekens, C. H. Hartard, H. Meierkord, G. Stocklin, M. D. Catala, W. C. McKay, E. Salmon, C. Navarro, I. Pastor, L. Canafoglia, M. De Braekeleer, P. K. Thomas, C. Mocellini, C. Pierre-Jerome, M. C. Dalakas, P. Pollak, M. Levivier, Niall Quinn, G. E. Rivolta, Z. Tunca, H. Zeumer, J. Garcia Tena, St. Guily, P. Gaudray, Johannes Kornhuber, V. Petrunjashev, R. Montesanti, R. J. Abbott, H. Petit, G. Kiteva-Trencevska, F. Carletto, C. Ramo, I. M. Pino, P. Beau, G. F. Mennuni, F. Moschian, F. Meneghini, B. Zdziarska, B. Fontaine, C. Stephens, G. Meco, K. Reiners, G. Badlan, M. Sessa, I. Degaey, S. M. Hassan, C. Albani, F. Caroeller, M. Schroeder, G. Savettieri, A. Novelletto, R. Kurita, P. Oschmann, I. Plaza, M. Oliveres, Simone Spuler, A. Molins, M. Schwab, J. R. Kalden, C. P. Gennaula, Y. Baklan, O. Picard, J. M. Léger, B. Mokri, E. Ghidoni, M. Jacob, D. Deplanque, W. JÄnisch, C. De Andres, P. De Deyn, G. Guomundsson, B. Herron, J. Barado, J. L. Gastaut, Guglielmo Scarlato, F. Poron, Nicola Jones, H. Teisserenc, C. P. Hawkins, A. J. Steck, H. C. Chandler, S. Blanc, J. H. Faiss, Jm. Soler Insa, I. Sarova-Ponchas, M. Malberin, A. Sackmann, G. De Vuono, K. Kaiser-Rub, K. Badhia, E. Szwabowska-Orzeszko, S. Ramm, C. Jodice, G. Franck, J. Marta-Moreno, R. Sciolla, C. Fritz, A. Attaccalite, F. Weber, E. Neuman, M. Cannata, A. Rodriguez, I. Nachainkin, R. Raffaele, T. S. Yu, N. Losseff, E. Fabrizio, C. Khati, M. Keipes, M. P. Ortega, M. Ramos-Alvarez, E. Brambilla, A. Tarasov, K. H. Wollinsky, O. B. Paulson, F. Boller, G. Bozzato, H. Wagnur, R. Canton, D. Testa, E. Kutluaye, M. Calopa, D. Smadja, G. Malatesta, F. Baggi, A. Stracciari, G. Daral, G. Avanzini, J. Perret, J. Arenas, P. Boon, I. Gomes, A. Vortmeyer, P. Cesaro, S. Venz, E. Bernd Ringelstein, N. Milani, D. Laplane, P. Seibel, E. Tournier-Lasserve, Alexis Brice, L. Motti, E. Wascher, R. J. Abbot, F. Miralles, A. Turon, P. De Camilli, G. Luz, G. C. Guazzi, S. Tekin, F. Lesoin, T. Kryst, N. Lannoy, F. Gerstenbrand, S. Ballivet, H. A. M. van Diemen, J. Lopez-ArLandis, P. Bell, A. Silvani, M. A. Garcia, S. Vorstrup, D. Langdon, S. Ueno, B. Sander, V. Ozurk, C. Gurses, P. Berlit, J. M. Martinez-Lage, M. Treacy, S. O. Rodiek, S. Cherninkova, J. Grimaud, P. Marozzi, K. Hasert, S. Goldman, S. H. Ingwersen, A. Taghavy, T. Roig, R. Harper, I. Sarova-Pinchas, Anthony H.V. Schapira, R. Lebtahi, A. Vidaller, B. Stankov, D. Link, J. p. Malin, V. Petrova, Ludwig Kappos, J. L. Ochoa, T. Torbergsen, M. Carpo, M. Donato, Simon Shorvon, J. Mieszkowski, J. Perez-Serra, Raymond Voltz, G. Comi, S. Rafique, A. Perez-Sempere, N. Khalfallah, S. Bailleul, M. Borgers, S. Banfi, S. Mossman, A. Laihinen, G. Filippini, R. A. Grunewald, E. Stern, H. D. Herrmann, A. G. Droogan, P. Xue, A. Grilo, L. La Mantia, J. H. J. Wokke, S. Pizzul, Kie Kian Ang, S. Rapaport, W. Szaplyko, B. Romero, P. Brunet, A. 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Navasa, J. Ballabriga, G. Broggi, T. Gudeva, C. Rose, J. Vion-Dury, J. A. Gastaut, J. Pniewski, Nicola J. Robertson, G. Kohncke, M. Billot, S. Gok, E. Castellli, F. Denktas, P. Bazzi, F. Spinelli, I. F. Moseley, C. D. Mardsen, B. Barbiroli, O. M. Koriech, A. Miller, Hiroaki Yoshikawa, F. X. Borruat, J. Zielasek, P. Le Coz, J. Pascual, A. Drouet, L. T. Giron, F. Schondube, R. Midgard, M. Alizadeh, M. Liguori, Lionel Ginsberg, L. Harms, C. Tilgner, G. Tognoni, F. Molteni, Mar Tintoré, M. Psylla, C. Goulon-Goeau, M. V. Aguilar, Massimo Filippi, K. H. Mauritz, Thomas V. Fernandez, C. Basset, S. Rossi, P. Meneses, B. Jandolo, T. Locatelli, D. Shechtcr, C. Magnani, R. Ferri, Bruno Dubois, J. M. Warier, S. Berges, F. Idiman, M. Schabet, R. R. Diehl, P. D'aurelio, M. Musior, Reinhard Hohlfeld, P. Smeyers, M. Olivé, A. Riva, C. A. Broere, N. Egund, S. Franceschetti, V. Bonavita, Nicola Canal, E. Timmermans, M. Ruiz, S. Barrandon, G. Vasilaski, B. Deweer, L. Galiano, S. F. T. M. de Bruijn, L. Masana, A. Goossens, B. Heye, K. Lauer, Heinz Gregor Wieser, Stephen R. Williams, B. Garavaglia, A. P. Sempere, F. Grigoletto, P. Poindron, R. Lopez-Pajares, I. Leite, T. A. McNell, C. Caucheteur, J. M. Giron, A. D. Collins, P. Freger, J. Sanhez Del Rio, D. A. Harn, K. Lindner, S. S. Scherer, G. Serve, M. Juncadella, X. Estivill, R. Binkhorst, M. Anderson, B. Tekinsoy, C. Sagan, T. Anastopoulos, G. Japaridze, S. Guillou, F. Erminio, Jon Sussman, P. G. Oomes, D. S. Rust, S. Mascheroni, O. Berger, M. Peresson, K. V. Toyka, T. W. Polder, M. Huberman, B. Arpaci, H. Ramtami, I. Martinez, Ph. Violon, P. P. Gazzaniga Pozzill, R. Ruda, P. Auzou, J. Parker, S. P. Morrissey, Jiahong Zhu, F. Rotondi, P. Baron, W. Schmid, P. Doneda, M. Spadaro, M. C. Nargeot, I. Banchs, J.S.P. van den Berg, R. Ferrai, M. Robotti, M. Fredj, Pedro M. Rodríguez Cruz, B. Erne, D. G. Piepgras, M. C. Arne-Bes, J. Escudero, C. Goetz, A. R. Naylor, M. Hallett, O. Abramsky, E. Bonifacio, L. E. Larsson, R. Pellikka, P. Valalentino, D. Guidetti, B. Buchwald, C. H. Lücking, D. Gauvreau, F. Pfaff, A. Ben Younes-Chennoufi, R. Kiefer, R. Massot, K. A. Hossmann, L. Werdelin, P. J. Baxter, U. Ziflo, S. Allaria, C. D. Marsden, M. Cabaret, S. P. Mueller, E. Calabrese, R. Colao, S. I. Bekkelund, M. Yilmaz, O. Oktem-Tanor, R. Gine, M. E. Scheulen, J. Beuuer, A. Melo, Z. Gulay, M. D. Have, C. Frith, D. Liberati, J. Gozlan, P. Rondot, Ch. Brunholzl, M. Pocchiari, J. Pena, L. Moiola, C. Salvadori, A. Cabello, T. Catarci, S. Webb, C. Dettmers, N. A. Gregson, Alexandra Durr, F. Iglesias, U. Knorr, L. Ferrini-Strambi, F. Kruggel, P. Allard, A. Coquerel, P. Genet, F. Vinuels, C. Oberwittler, A. Torbicki, P. Leffers, B. Renault, B. Fauser, C. Ciano, G. Uziel, J. M. Gibson, F. Anaya, C. Derouesné, C. N. Anagnostou, M. Kaido, W. Eickhoff, G. Talerico, M. L. Berthier, A. Capdevila, M. Alons, D. Rezek, E. Wondrusch, U. Kauerz, D. Mateo, M. A. Chornet, Holon, N. Pinsard, I. Doganer, E. Paoino, H. Strenge, C. Diaz, J. R. Brasic, W. Heide, I. Santilli, W. M. Korn, D. Selcuki, M. J. Barrett, D. Krieger, T. Leon, T. Houallah, M. Tournilhac, C. Nos, D. Chavot, F. Barbieri, F. J. Jimenez-Jimenez, J. Muruzabal, K. Poeck, A. Sennlaub, L. M. Iriarte, L. G. Lazzarino, C. Sanz, P. A. Fischer, S. D. Shorvon, R. Hoermann, F. Delecluse, M. Krams, O. Corabianu, F. H. Hochberg, Christopher J. Mathias, B. Debachy, C. M. Poser, L. Delodovici, A. Jimenez-Escrig, F. Baruzzi, F. Godenberg, D. Cucinotta, P. J. Garcia Ruiz, K. Maier-Hauff, P. R. Bar, R. Mezt, R. Jochens, S. Karakaneva, C. Roberti, E. Caballero, Joseph E. Parisi, M. Zamboni, T. Lacasa, B. Baklan, J. C. Gautier, J. A. Martinez-Matos, W. Pollmann, G. Thomas, L. Verze, E. Chleide, R. Alvarez Sala, I. Noel, E. Albuisson, O. Kastrup, S. I. Rapoport, H. J. Braune, H. Lörler, M. Le Merrer, A. Biraben, S. Soler, S. J. Taagholt, U. Meyding-Lamadé, K. Bleasdale-Barr, Isabella Moroni, Y. Campos, J. Matias-Guiu, G. Edan, M. G. Bousser, John B. Clark, J. Garcia de Yebenes, N. K. Olsen, P. Hitzenberger, S. Einius, Aj Thompson, Ch. J. Vecht, T. Crepin-Leblond, Klaus L. Leenders, A. Di Muzio, L. Georgieva, René Spiegel, K. Sabey, D. Ménégalli, J. Meulstee, U. Liszka, P. Giral, C. Sunol, J. M. Espadaler, A. D. Crockar, K. Varli, G. Giraud, P. J. Hülser, A. Benazzouz, A. Reggio, M. Salvatore, K. Genc, M. Kushnir, S. Barbieri, J. Ph. Azulay, M. Gianelli, N. Bathien, A. AlMemar, F. Hentati, I. Ragueneau, F. Chiarotti, R. C. F. Smits, A. K. Asbury, F. Lacruz, B. Muller, Alan J. Thompson, Gordon Smith, K. Schmidt, C. Daems Monpeun, Juergen Weber, A. Arboix, G. R. Fink, A. M. Cobo, M. Ait Kaci Ahmed, E. Gencheva, Israel-Biet, G. Schlaug, P. De Jonghe, Philip Scheltens, K. Toyka, P. Gonzalez-Porque, A. Cila, J. M. Fernandez, P. Augustin, J. Siclia, S. Medaglini, D. E. Ziogas, A. Feve, L. Kater, G. J. E. Rinkel, D. Leppert, Rüdiger J. Seitz, S. Ried, C. Turc-Carel, G. Smeyers, F. Godinho, M. Czygan, M. Rijntjes, E. Aversa, M. Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg
Subjects: Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published: 1994

18. Book Reviews

Author: Y. Pirson, V. Castronoyo, J.J. Martin, J. De Plaen, and E. Marion
Subjects: General Medicine
Published: 1994

19. Crisis Intervention Team of Avilés. Results after three years

Author: A.M. González Álvarez, E. Lago Machado, L. Pérez Gómez, E. Lanza Quintana, and J.J. Martínez Jambrina
Subjects: crisis intervention team Aviles, Psychiatry, RC435-571
Abstract: Introduction This Crisis Intervention Team was born in October 2018 with the aim of intensifying the treatment of people in psychiatric crisis situation. Objectives Provide an intensive and early assessment and approach in a timely manner. It also provides home care if necessary. Methods The team intensively performs scheduled visits, emergencys, telephone interventions and home care. It is in constant coordination with other structures of the mental health and socio-health network. Results A total of 83 patients have been included in our team since its inception. The youngest was 17 years old and the oldest 83 years old (exceptional case in evaluation). The mean age was 45.6 years. 67.4% were female (56 women) and 32.5% male (27 men). The delay in care did not exceed 48 hours. 200 patients were evaluated into suicide protocol, with ages ranging from 15 to 85 years, with a mean age of 45.4 years. The delay in care does not exceed 10 days. Conclusions This is a team that offers a rapid response, dedicates the necessary time for a correct evaluation of the risk, of the evolution and tries to establish a therapeutic alliance in record time. It is able to tolerate a certain degree of uncertainty, manage and tolerate the level of risk. He stands out for being flexible and dynamic in order to be able to adapt to the patients and theirs circumstances. This requires empathy, closeness and commitment. Disclosure No significant relationships.
Published: 2022
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20. Evidence for Allelic Heterogeneity in Familial Early-Onset Alzheimer's Disease

Author: J.J. Martin, John Hardy, Alison Goate, Martin N. Rossor, C. Van Broeckhoven, A. Hofman, Antoon Vandenberghe, C M van Duijn, and Michael Mullan
Subjects: Genetic Markers, Chromosomes, Human, Pair 21, Genetic Linkage, Genetic counseling, Population, Chromosome Disorders, Locus (genetics), Biology, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Risk Factors, Genetic linkage, medicine, Humans, Early-onset Alzheimer's disease, 030212 general & internal medicine, Allele, education, Alleles, Aged, Genes, Dominant, Chromosome Aberrations, Genetics, education.field_of_study, Models, Genetic, Genetic Carrier Screening, Middle Aged, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Allelic heterogeneity, Age of onset
Abstract: Age of onset was examined for 139 members of 30 families affected by early-onset AD. Most (77%) of the variance of age of onset derived from differences between rather than within families. The constancy of age of onset within families was also observed in an analysis restricted to families derived from a population-based epidemiological study with complete ascertainment of early-onset AD. Furthermore, we observed clustering of age of onset within those families that support linkage to the predisposing locus on chromosome 21. Our data are compatible with the view that allelic heterogeneity at the AD locus may account for the similarity in age of onset within families. This finding may be of value for scientific studies of AD as well as for genetic counselling.
Published: 1991

21. Infantile presentation of the mitochondrial A8344G mutation

Author: J.J. Martin, F. Pierart, Sara Seneca, Emmanuel Scalais, O. Battisti, R. Van Coster, Willy Lissens, Christian Nuttin, B. De Paepe, René Stevens, L. De Meirleir, Joél Smet, Department of Embryology and Genetics, and Pediatrics
Subjects: Pathology, medicine.medical_specialty, business.industry, abnormal breathing pattern, systemic hypertension, Oxidative phosphorylation, Bioinformatics, Leigh syndrome, MERRF, Neurology, Mutation (genetic algorithm), medicine, Neurology (clinical), Presentation (obstetrics), business, brainstem lesions
Abstract: no abstract
Published: 2007

22. Spinocerebellar ataxia type 7 associated with pigmentary retinal dystrophy

Author: C. Van Broeckhoven, J.J. Martin, and Andrej Michalik
Subjects: Retinal degeneration, Male, Ataxin 7, Context (language use), Nerve Tissue Proteins, Biology, Pathogenesis, Trinucleotide Repeats, Retinitis pigmentosa, Genetics, medicine, Humans, Spinocerebellar Ataxias, Age of Onset, Genetics (clinical), Ataxin-7, Inclusion Bodies, Retinal Degeneration, Polyglutamine tract, medicine.disease, Pedigree, Disease Models, Animal, Spinocerebellar ataxia, biology.protein, Female, Trinucleotide repeat expansion, Peptides
Abstract: Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant, late-onset, slowly progressive disorder, primarily characterized by gradual loss of motor coordination, resulting from dysfunction and degeneration of the cerebellum and its connecting pathways. The disease is caused by expansion of a CAG trinucleotide repeat within the SCA7 gene, which encodes a polyglutamine tract within a novel protein, termed ataxin-7. The expansion of polyglutamine-encoding CAG repeats in dissimilar genes underlies eight neurodegenerative conditions besides SCA7, including a number of dominant ataxias related to SCA7. Although elongated polyglutamine itself can initiate neuronal dysfunction and death, its toxicity is modulated by the context of the disease proteins, as evidenced by the differing clinical and pathological presentation of the various disorders. In this respect, it is exciting that SCA7 constitutes the only polyglutamine disorder, in which the photoreceptors of the retina are also severely affected, leading to retinal degeneration and blindness. Since the discovery of the SCA7 mutation, numerous studies attempted to pinpoint the molecular mechanisms underlying the unique features of SCA7, particularly the retinal involvement. Here we summarize the clinical, pathological, and genetic aspects of SCA7, and review the current understanding of the pathogenesis of this disorder.
Published: 2003

23. A prospective study of CSF markers in 250 patients with possible Creutzfeldt-Jakob disease

Author: J Boons, B Van Everbroeck, Patrick Cras, S Quoilin, and J.J. Martin
Subjects: Paper, Adult, Male, Pathology, medicine.medical_specialty, Tyrosine 3-Monooxygenase, animal diseases, Tau protein, tau Proteins, Sensitivity and Specificity, Creutzfeldt-Jakob Syndrome, Central nervous system disease, Degenerative disease, Cerebrospinal fluid, Predictive Value of Tests, mental disorders, medicine, Humans, Dementia, Aged, Amyloid beta-Peptides, biology, business.industry, Middle Aged, medicine.disease, nervous system diseases, Psychiatry and Mental health, 14-3-3 Proteins, Predictive value of tests, Disease Progression, biology.protein, Female, Surgery, Neurology (clinical), medicine.symptom, business, Myoclonus, Biomarkers
Abstract: To investigate various cerebrospinal fluid (CSF) markers that could assist in the clinical diagnosis of Creutzfeldt-Jakob disease (CJD).CSF samples were analysed for the presence of 14-3-3 protein, microtubule associated protein tau, and beta amyloid in 250 patients with possible CJD. Densitometric analysis was used to quantify the level of 14-3-3 in all patients.Analysis of the clinical data showed that cerebellar signs or myoclonus combined with progressive dementia were the main features leading to a clinical suspicion of CJD. While 14-3-3 detection had a sensitivity of 100% and a specificity of 92%, tau determination using a threshold of 1300 pg/ml had a sensitivity of 87% and a specificity of 97%. If the protocol for the analysis of 14-3-3 was modified (using densitometric analysis) a higher specificity (97%) could be obtained, but with a lower sensitivity (96%). Maximum sensitivity, specificity, and positive predictive value were obtained with a combination of 14-3-3 and beta amyloid determinations. The concentrations of 14-3-3 and tau in the CSF were reduced in CJD patients with a long duration of disease (more than one year; p0.05). The concentrations of 14-3-3 or tau were lowest at the onset or at the end stage of the disease, while the beta amyloid concentration remained low throughout the course of the disease.Both 14-3-3 and tau protein are sensitive and specific biomarkers for CJD. The combination of 14-3-3 and beta amyloid analysis resulted in the maximum sensitivity, specificity, and positive predictive value. When these biomarkers are used in the diagnosis of CJD, the phase of the disease in which the CSF sample was obtained should be taken into account. Disease duration, dependent on the PrP genotype, also has a significant influence on the level of 14-3-3 and tau in the CSF.
Published: 2003

24. Book Reviews

Author: E. Goffin, J.J. Martin, R. Six, J.M. Guérit, and Th. De Barsy
Subjects: General Medicine
Published: 1994

25. High-temperature acoustic loss of AT-cut quartz crystals

Author: J.J. Martin and J.E. Ferris
Subjects: Range (particle radiation), Materials science, business.industry, Al content, Relaxation (NMR), Analytical chemistry, chemistry.chemical_element, Temperature measurement, Crystallographic defect, Resonator, Optics, chemistry, Aluminium, business, Quartz
Abstract: Sensor applications are increasing the use of quartz crystals at high-temperatures. At these temperatures the interstitial alkalis thermally escape from the traps and drift in the shallow potential wells of the Z-axis channel. Their random motion leads to a thermally activated acoustic loss which may degrade oscillator performance. Point defects may also lead to acoustic loss peaks; Fraser has reported a peak near 300/spl deg/C in swept quartz. We have investigated the acoustic loss of unswept (Li-compensated), Na-compensated, and swept (H-compensated) AT-cut resonator blanks from room temperature to over 400/spl deg/C. In swept quartz, we find a loss peak centered at 600 K which increases linearly with the aluminum content. This peak most likely results from relaxation of the Al-OH center. The acoustic loss of unswept and Na-compensated resonators remained relatively constant up to about 500 K; at higher temperatures it increased exponentially with T(K)/sup -1/. The Al-OH loss peak in the swept blanks with higher Al content caused them to have a larger loss in the 400 to 600 K range than unswept blanks. >
Published: 2002

26. Characterization of the ecophysiological responses of three pomegranate cultivars to salinity

Author: A. OLMO, F. GARCIA-SANCHEZ, I. SIMON, V. LIDON, M. ALFOSEA-SIMON, J.M. CAMARA-ZAPATA, J.J. MARTINEZ-NICOLAS, and S. SIMON-GRAO
Subjects: chloride toxicity, fruit tree, oxidative stress, photosynthesis, sodium toxicity, water stress., Botany, QK1-989
Abstract: In order to understand photosynthetic responses of pomegranate plants (Punica granatum L.) to salinity, an experiment was conducted with three varieties, 'Mollar de Elche', 'Valenciana', and 'Wonderful', irrigated with seven salt concentrations (0, 40, 60, 80, 100, 120, and 140 mM NaCl). At the end of the experiment, parameters of gas exchange, chlorophyll fluorescence, water relations, and sugar and chloride concentrations were measured in leaves. As the concentration of NaCl increased, the concentration of Cl- in leaves was elevated, and the CO2 assimilation rate, stomatal conductance, variable fluorescence/maximum fluorescence ratio, PSII quantum yield, and total soluble sugars decreased. In 'Valenciana', the decrease of the net assimilation of CO2 could occur due to the closure of stomata, while in 'Mollar' and 'Wonderful', this was due to damage caused by Cl- toxicity. The study of carbohydrates also suggests a different behavior of carbon metabolism in the three varieties.
Published: 2019
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27. Detection of beta-A4 amyloid and its precursor protein in the muscle of a patient with juvenile neuronal ceroid lipofuscinosis (Spielmeyer-Vogt-Sjogren)

Author: Antonio Federico, Carlo Casali, Alessandro Malandrini, Chantal Ceuterick, M.T. Dotti, F.M. Santorelli, J.J. Martin, U. Lübke, N. De Stefano, Gianni Guazzi, and Marcello Villanova
Subjects: Adult, Male, Pathology, medicine.medical_specialty, Biopsy, Immunocytochemistry, Muscle Fibers, Skeletal, amyloid precursor protein, juvenile neuronal ceroid lipofuscinosis, Fluorescence, beta-A4 amyloid, amyloid precursor protein, juvenile neuronal ceroid lipofuscinosis, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Amyloid beta-Protein Precursor, Macular Degeneration, Neuronal Ceroid-Lipofuscinoses, Seizures, Intellectual Disability, mental disorders, medicine, Amyloid precursor protein, Humans, Lymphocytes, Skin, Muscle biopsy, Amyloid beta-Peptides, biology, medicine.diagnostic_test, Muscles, Autophagy, Acid phosphatase, beta-A4 amyloid, medicine.disease, Immunohistochemistry, Vacuoles, biology.protein, Neuronal ceroid lipofuscinosis, Neurology (clinical)
Abstract: Muscle biopsy tissue from a patient affected by the juvenile form of neuronal ceroid lipofuscinosis (NCL) was studied immunohistochemically using antibodies to beta-amyloid peptide and amyloid precursor protein. Positive reaction in muscle was specifically localized to autophagic vacuoles and blood vessel walls. Increased acid phosphatase reaction suggested enhanced lysosomal activity. We hypothesize that beta-amyloid is deposited in NCL muscle by a lysosomal mechanism similar to that proposed in other disorders involving beta-amyloid.
Published: 1999

28. Familial cervical artery dissections: Clinical, morphologic and genetic studies

Author: Ingrid Hausser, J.J. Martin, and Philippe Lyrer
Subjects: medicine.medical_specialty, business.industry, Cervical Artery, Medicine, Surgery, Cardiology and Cardiovascular Medicine, business
Published: 2007

29. Solubility of sickle hemoglobin measured by a kinetic micromethod

Author: Dan Liao, Frank A. Ferrone, J.M. Manning, J.J. Martin de Llano, and J.P. Himanen
Subjects: Kinetics, Hemoglobin, Sickle, Biophysics, Analytical chemistry, Activation energy, Heme, Reaction rate constant, Leucine, Molecule, Humans, Point Mutation, Centrifugation, Solubility, Alanine, Photolysis, Chemistry, Microchemistry, Photodissociation, Hemoglobin A, Polymerization, Carboxyhemoglobin, Models, Chemical, Thermodynamics, Research Article
Abstract: We have developed a photolytic method to determine the concentration of reactive hemes in a solution in the presence of a trace amount of CO. By measurement of the bimolecular rate of CO binding, and by calibration of the rate constant under equivalent conditions, the concentration of the reactive hemes can be determined. In a solution of sickle hemoglobin, the molecules in the gel contribute negligibly to the recombination rate, allowing the concentration of the molecules in the solution phase to be determined. To optimize signal to noise, modulated excitation methods were employed, although the method could also be used with pulse techniques and suitable signal averaging. Because the optical method employs a microspectrophotometer, only a few microliters of concentrated Hb solution is required to reproduce the entire temperature dependence of the solubility previously determined by centrifugation using milliliter quantities of solutions of the same concentration. This should be especially useful for studies of site-directed mutants, and we present results obtained on one such HbS in which Leu 88 beta has been replaced by Ala. The free energy difference in the polymerization of the Leu 88 beta double mutant is consistent with known differences in the amino acid hydrophobicities. The calibration required for these experiments also provides an excellent determination of the activation energy for binding the first CO to deoxy Hb.
Published: 1996

30. Parasitoides del bicho canasto, Oiketicus platensis (Lepidoptera: Psychidae) en el caldenal pampeano

Author: E. M. BAUDINO, J.J. MARTÍNEZ, L. FERNÁNDEZ, Y.H. GEIST, H.E. GALLARDO, and A. REIMER
Subjects: bicho de cesto, parasitoides, diptera, hymenoptera, Agriculture, Agriculture (General), S1-972
Abstract: Desde el 2006 se observa un incremento poblacional importante de Oiketicus platensis Berg en los bosques de caldén de la provincia de La Pampa. Los objetivos del presente trabajo fueron: 1) caracterizar la comunidad de parasitoides larvales, 2) determinar qué especies de parasitoide son más abundantes. El estudio se llevó a cabo en 3 sitios de la provincia pertenecientes a la región togreográfica del Espinal. El muestreo de larvas se extendió desde noviembre de 2012 hasta marzo de 2013. En total, 17 especies de parasitoides fueron identificadas. Se reconocieron 15 especies de avispas parasitoides pertenecientes a 9 familias: Eulophidae, Encyrtidae, Eurytomidae, Eupelmidae, Torymidae, Chalcididae, Ichneumonidae, Baconidae y Bethylidae. Además, se identificaron 2 especies de moscas parasitoides pertenecientes a la familia Tachinidae. Los parasitoides aparecieron un mes después del nacimiento de las larvas. El porcentaje de parasitoidismo larval fue de 17,6%, con predominancia (81,6%) de moscas parasitoides.
Published: 2017

31. A theoretical study of the effect of electric charges on the efficiency with which aerosol particles are collected by ice crystal plates

Author: J.J Martin, H.R Pruppacher, and P. K. Wang
Subjects: Range (particle radiation), Ice crystals, Chemistry, business.industry, Radius, Electric charge, Molecular physics, Thermophoresis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Aerosol, Biomaterials, Colloid and Surface Chemistry, Optics, Diffusiophoresis, Astrophysics::Earth and Planetary Astrophysics, business, Physics::Atmospheric and Oceanic Physics, Brownian motion
Abstract: Two theoretical models are presented which allow computing the efficiency with which electrically charged aerosol particles of radius 0.001 ≤ r ≤ 10 μm are collected by electrically charged plate-like ice crystals of radius 50 ≤ ac ≤ 640 μm in air of various relative humidities and of 700 mb and −10°C. Particle capture due to thermophoresis, diffusiophoresis, Brownian diffusion, inertial impaction, and electrostatic forces is considered. It is shown that Brownian diffusion dominates the capture process by ice crystals if r ≤ 0.01 μm, while inertial impaction controls the capture process if r > 0.1 μm. For aerosol particles of 0.01 ≤ r ≤ 0.1 μm, the collection efficiency is controlled by phoretic forces. Electrical forces significantly affect the collection of aerosol particles in the size range of 0.01 ≤ r ≤ 5 μm. Trajectory analysis demonstrates that electrically charged and uncharged aerosol particles are preferentially captured at the rim of plate-like ice crystals. Electrically neutral ice crystals of NRe < 50 capture particles only on the underside of the ice crystal. Ice crystals which are electrically charged collect aerosol particles by rear capture if NRe ≤ 0.5.
Published: 1980

32. Book Reviews

Author: J.J. Martin, M. Verstraete, E. Eggermont, and H. Degreef
Subjects: General Medicine
Published: 1977

33. Pronóstico de los pacientes que desarrollan complicaciones perivalvulares

Author: M.L. Fernández-Gassó, J.A. Giner-Caro, J.J. Martínez-Díaz, R. Rojano-Torres, A. Jimeno-Almazán, N. Cobos-Trigueros, R. Rubio Patón, J.C. Bonaque González, R.M. Soto Ruíz, and F.G. Clavel Ruipérez
Subjects: Medicine, Surgery, RD1-811
Published: 2018
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34. Prevalencia de valvulopatías y otros factores predisponentes en nuestra serie de endocarditis infecciosa

Author: M.L. Fernández-Gassó, J.A. Giner-Caro, M.J. del Amor-Espín, B. Alcaraz-Vidal, J.J. Martínez-Díaz, R. Rojano-Torres, R.M. Soto Ruíz, M. Melero Nicolás, I.A. García-Escribano García, and S. Wasniewski
Subjects: Medicine, Surgery, RD1-811
Published: 2018
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35. Electrodiffusion (sweeping) of ions in quartz-a review

Author: J.J. Martin
Subjects: Materials science, Acoustics and Ultrasonics, Hydrogen, Analytical chemistry, chemistry.chemical_element, Ion, chemistry, Electrical resistivity and conductivity, Electric field, Electrode, Electrical and Electronic Engineering, Dislocation, Instrumentation, Quartz, Crystal oscillator
Abstract: Sweeping, a high-temperature process that selectively exchanges monovalent ions in quartz, is reviewed. Sweeping is used commercially to replace interstitial alkalis with hydrogen. Electrodiffusion improves the radiation hardness of quartz oscillator crystals and lowers the etch channel density. Sweeping affects the substitutional aluminum with its associated alkali and the extended dislocation networks with their precipitated impurities. At high temperatures the interstitials are freed and swept down the open Z-axis channels by an applied electric field. These interstitials can then be swept out at the negative electrode, provided replacement ions, usually hydrogen, are brought in at the positive electrode. Thus, the alkali associated with the aluminum is replaced by a hydrogen, and the precipitates in the dislocation networks are modified so that they are less reactive to the etchants. With the field applied at a room temperature, a peak or plateau in the sample current is observed during warm-up near 250-300 degrees C, followed by a decay at the 500 degrees C sweeping temperature. When the current becomes steady, the sweeping is thought to be complete. While infrared and high-temperature resistance measurements are useful, EPR techniques seem to provide the most reliable test for complete ion exchange at the aluminum site. >
Published: 1988

36. Adult ceroid-lipofuscinosis : diagnostic-value of biopsies and of neurophysiological investigations

Author: K Jacobs, L Swerts, J.J. Martin, C Ceuterick, and A Vercruyssen
Subjects: Adult, Male, congenital, hereditary, and neonatal diseases and abnormalities, Pathology, medicine.medical_specialty, Biopsy, Eccrine sweat, Sensory system, Eccrine Glands, Biology, Synaptic Transmission, Diagnosis, Differential, Neuronal Ceroid-Lipofuscinoses, Evoked Potentials, Somatosensory, Ceroid lipofuscinosis, medicine, Humans, Kufs disease, Skin, medicine.diagnostic_test, Muscles, Anatomy, Neurophysiology, medicine.disease, Pedigree, Microscopy, Electron, Psychiatry and Mental health, Somatosensory evoked potential, Surgery, Neurology (clinical), Human medicine, Differential diagnosis, Research Article
Abstract: In a sibship of ten, three brothers presented with an adult form of ceroid-lipofuscinosis. The diagnosis was confirmed by necropsy of the first patient and was made by electron microscopy of eccrine sweat glands and of skeletal muscles in the two others. Somatosensory evoked potentials were characterised by biphasic, nearly monophasic, very high voltage complexes totally unlike those found in normal controls. Similar sensory evoked potentials were however recorded in other types of ceroid-lipofuscinosis. While electron microscopy of easily available tissues gives fairly specific results, sensory evoked potentials can bring supportive diagnostic evidence in adult ceroid-lipofuscinosis.
Published: 1982

37. THERMAL CONDUCTIVITY OF MAGNESIUM STANNIDE

Author: J.J. Martin, H.R. Shanks, and G.C. Danielson
Subjects: Materials science, chemistry, Stereochemistry, Magnesium, Metallurgy, chemistry.chemical_element, Stannide
Abstract: C . E r r o r s 3 5 I V . R E S U L T S A N D D I S C U S S I O N _ 4 l A . T h e r m a l C o n d u c t i v i t y R e s u l t s 4 1 B . T h e r m a l C o n d u c t i v i t y D i s c u s s i o n 4 1 C . S e e b e c k C o e f f i c i e n t R e s u l t s a n d D i s c u s s i o n 5 9 D . C o n c l u s i o n s 6 6 E . F u t u r e W o r k 6 7 V . L I T E R A T U R E C I T E D 6 8 V I . A C K N O W L E D G E M E N T S . 7 2 V I I . A P P E N D I X 7 3 L I S T O F T A B L E S P a g e T a b l e 1 . S a m p l e c h a r a c t e r i s t i c s 2 5 T a b l e 2 . R e l a x a t i o n t i m e p a r a m e t e r s 4 9 T a b l e 3 . D i f f u s i o n S e e b e c k c o e f f i c i e n t p a r a m e t e r s 6 2 T a b l e 4 . S a m p l e e x p e r i m e n t a l d a t a 7 3 T a b l e 5 . T h e r m a l c o n d u c t i v i t y a n d S e e b e c k c o e f f i c i e n t r e s u l t s 7 4
Published: 1967

38. THE EFFECT OF RADIATION ON CHEMICAL REACTIONS. Final Report

Author: L.C. Anderson and J.J. Martin
Subjects: Nuclear physics, Fission products, Fission, Chemistry, Nuclear engineering, Radiation, Chemical reaction, Waste processing
Abstract: Primarily the studies have been devoted to a search for chemical reactions which are promoted by gamma radiation. The underlying purpose behind the studies has been to develop uses for the radiation available from waste fission prcducts. A brief description of all the reactions studied during the program is presented along with appropriate references to the original reports and publications. These give the detailed account of the work done on each reaction and the reader is referred to them for more complete information. (auth)
Published: 1957

39. CHLORINATION OF SOME AROMATIC COMPOUNDS UNDER THE INFLUENCE OF GAMMA RADIATION

Author: L.C. Anderson, D.E. Harmer, and J.J. Martin
Subjects: chemistry.chemical_compound, chemistry, Chlorine, chemistry.chemical_element, Organic chemistry, Cobalt-60, Radiation, Photochemistry, Benzene, Toluene
Published: 1952

40. PREPARATION OF RADIATION SOURCES FROM FISSION PRODUCTS BY THE CLAY PROCESS

Author: J.J. Martin and J.E. Schoolmeester
Subjects: inorganic chemicals, chemistry.chemical_compound, Fission products, Montmorillonite, Materials science, chemistry, Waste management, Radiation, National laboratory, USable, complex mixtures, Waste processing, Waste disposal
Abstract: This study was made to determine the feasibility of producing usable radiation sources by the montmorillonite clay process. The clay process was developed at Brookhaven National Laboratory primarily to solve the problem of ultimately disposing of waste fission products. After reviewing the process in detail, it is shown that radiation sources may be prepared with specific activity as high as 4.5 curies of Ce/sup 137/ per gram of clay. Sources of this strength would be entirely suitable for such processing applications as promotion of chemical reactions, preservation of foods, or sterilization of drugs. Furthermore, the operations involved in the clay process are simpler and more straightforward thin those of any other process for making radiation sources from fission products. It is concluded from this study that some clay sources should be prepared to demonstrate the actual process. (auth)
Published: 1957

41. THERMAL CONDUCTIVITY OF MAGNESIUM GERMANIDE

Author: J.J. Martin, H.R. Shanks, and G.C. Danielson
Subjects: Germanide, chemistry.chemical_compound, Materials science, Thermal conductivity, chemistry, Magnesium, Metallurgy, chemistry.chemical_element
Published: 1968

42. Paleoseismic analysis of the San Vicente segment of the El Salvador Fault Zone, El Salvador, Central America

Author: C. CANORA, P. VILLAMOR, J.J. MARTÍNEZ DÍAZ, K.R. BERRYMAN, J.A. ÁLVAREZ GÓMEZ, R. CAPOTE, and W. HERNÁNDEZ
Subjects: El Salvador Fault Zone, Active fault characterisation, Strike-slip fault, Volcanic arc, Paleoseismic studies, Science, Geology, QE1-996.5
Abstract: The El Salvador earthquake of February 13th 2001 (Mw 6.6) was associated with the tectonic rupture of the El Salvador Fault Zone. Paleoseismic studies of the El Salvador Fault Zone undertaken after this earthquake provide a basis for examining the longer history of surface rupturing earthquakes on the fault. Trenching at five sites along the San Vicente segment, a 21km-long and up to 2km-wide central section of the El Salvador Fault Zone, shows that surface fault rupture has occurred at least seven times during the past 8ka. Single-event displacements identified at each trench vary from several decimetres to at least 3.7m. Fault trace mapping, geomorphic analysis, and paleoseismic studies indicate a maximum magnitude for the El Salvador Fault Zone is c. Mw 7.6, with a recurrence interval of around 800yr. Earthquakes of Mw 6.6 or smaller, such as the February 2001 event are unlikely to be identified in the paleoseismic trenches, so our observations represent the minimum number of moderate to large earthquakes that have occurred on this part of the El Salvador Fault Zone. We observe significant variability in single-event displacement in the trenches, which we interpret as possible cascade rupture of several segments of the El Salvador Fault Zone. Combining displacements of river courses and the timing of events revealed in the trenches, we calculate a slip rate of c. 4mm/yr for El Salvador Fault Zone, identifying the fault zone as a major tectonic feature of the region, and a major source of seismic hazard and risk in El Salvador.
Published: 2012

43. SAGRARIO Y MANIFESTADOR EN EL RETABLO BARROCCO ESPAÑOL

Author: J.J. Martín González
Subjects: retablo, sagrario, manifestador, tabernáculo, ostensorio, History of the arts, NX440-632
Abstract: The altarpiece appenred as didactic iconography placed behind the main altar. But the valomtion that the Council of Trent gave to the Eucharist made this the predominant objective in the baroque period. Sheme, monstrance and tabeinacle are usually terms equivalent to the place where the sacred forms are kept. But the tabernacle has an additional meaning: momentality, It has the shape of a tower; the upper part is the monstrance, a transparent recipient in which the sucred form is placed for everlasting worship. The form is visible in the monstrance that is generally presented in a theatrical manner (scene), with a small curtain or revolving body. The altarpiece is part of the theatrical scenery, which helps to create more emotion when the holy sacrament is shown.
Published: 1997

44. EL PABELLÓN DE LA SANTA SEDE EN EL PABELLÓN DE LA EXPOSICIÓN DE SEVILLA. EXPO-92

Author: J.J. Martín González
Subjects: History of the arts, NX440-632
Abstract: The Vatican Pavlion at the 1992 World Fair of Seville, Expo 92, was devoted to explain the evangelizatiori of America, illustrated with works of art, books, and maps brought from different collections and archives. The Pavilion gathered a great deal of materials, ranging from creations of great artists to specimens of popular art. The exhibition payed attention to cultural and geographical aspects of evangelization, and showed grammar and vocabulary books beside examples of cartography. The scope of faith with Christ as protagonist, was represented by a series of masterpieces by El Greco, Caravaggio, Murillo or Goya. Besides, it also liad a memory to principal names relaten to the discovery, and to the activities of evangelization carried out by ecclesiastics and missionaries, with the exhibition of documents, plans, paintings, sculptures and gold and silver works.
Published: 1993

45. AVANCE DE UNA TIPOLOGÍA DEL RETABLO BARROCO

Author: J.J. Martín González
Subjects: History of the arts, NX440-632
Abstract: The Hispanic Baroque has one of its main exhibitions in the retable, to which scholars are paying an increasing attention. This paper outlines the study of the typology or order of the whole. artending first to such important elements as the tabernacle and the manifestador [manifester, exhibitor], i.e. the Eucharisric core, both having a main significance during the baroque rima, beside the special effects of the transparents. We continue with the analysis of the structural tipology, with a starting point in the rerable of El Escorial and other models in the palladian line which one devoloped mainly in the frame-retable (this type will produce very baroque creations). From the middle of the XVIIth century onwards, there is a turn to the primacy of an only order, also advancing to the irlerease of the bench and to the use of revisted columns. This type of an only order and with semicircular attic or rop is the commonest in Spain, though there exists a logical range of variations. Furthermore. the retable may apperit hacked against a right wall, but also against curved or polygonal presbytey, to cover in completely up to the vault and to form a concave structure with a shell crown which defines the typical riche-rerable. The tendency in the tabole is to stress the central part, which constitutes the agglutinating element of the structure, though there still persist several bodies. This the priority. is given to the titular image's niche. After the structural typology in follows an analysis of the typology of contents, with definitions of the reliquary-. rosay-, and painting support-, retables, and the big transparernts. Finally, we study the baldachin and its variations: exent baldachins. not exent ones. baldachin- retable and half baldachin.
Published: 1989

46. ENGINEERING MICROBES FOR PLANT POLYKETIDE BIOSYNTHESIS

Author: François-Xavier Lussier, David Colatriano, Zach Wiltshire, Jonathan E. Page, and Vincent J.J. Martin
Subjects: Plant polyketides, metabolic engineering, microbes, Biotechnology, TP248.13-248.65
Abstract: Polyketides are an important group of secondary metabolites, many of which have important industrial applications in the food and pharmaceutical industries. Polyketides are synthesized from one of three classes of enzymes differentiated by their biochemical features and product structure: type I, type II or type III polyketide synthases (PKSs). Plant type III PKS enzymes, which will be the main focus of this review, are relatively small homodimeric proteins that catalyze iterative decarboxylative condensations of malonyl units with a CoA-linked starter molecule. This review will describe the plant type III polyketide synthetic pathway, including the synthesis of chalcones, stilbenes and curcuminoids, as well as recent work on the synthesis of these polyketides in heterologous organisms. The limitations and bottlenecks of heterologous expression as well as attempts at creating diversity through the synthesis of novel “unnatural” polyketides using type III PKSs will also be discussed. Although synthetic production of plant polyketides is still in its infancy, their potential as useful bioactive compounds makes them an extremely interesting area of study.
Published: 2012
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