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1. Mastitis y muerte en una oveja Corriedale asociada a una infección con Mycoplasma spp. en la provincia de Buenos Aires

Author

German Cantón, María Andrea Fiorentino, Eleonora Lidia Morrell, Valeria Scioli, Facundo Urtizbiría, Juan Ignacio Lobo, Erika Sticotti, and Pablo Tamiozzo

Subjects
General. Including nature conservation, geographical distribution, QH1-199.5, Biology (General), QH301-705.5, Agriculture (General), S1-972, Veterinary medicine, SF600-1100, Cattle, SF191-275
Abstract

Las infecciones con Mycoplasma spp. están asociadas con diferentes cuadros clínicos en rumiantes: mastitis, neumonía, artritis, otitis, entre otros. Sin embargo, existen escasos reportes de cuadros clínicos asociados con estas infecciones en pequeños rumiantes de Argentina. Mycoplasma agalactiae y Mycoplasma capricolum son los agentes causales de la agalactia contagiosa, enfermedad exótica en la región. Entonces, es necesario realizar vigilancia epidemiológica estricta de estos patógenos. Se diagnosticó un cuadro de mastitis severa y muerte en una oveja Corriedale de 7 años de edad, en una majada de la provincia de Buenos Aires. La oveja había parido mellizos 15 días antes que comenzara a manifestar enfermedad clínica y muriera. Durante su necropsia, se observó linfoadenomegalia supramaria, glándula mamaria aumentada de tamaño y firme, con piel cianótica y edema superficial. El parénquima mamario presentaba múltiples focos caseosos blanquecinos. Focos caseosos similares se observaron en el lóbulo caudo-ventral del pulmón derecho. En el análisis histopatológico se observó mastitis necrotizante multifocal severa crónica y bronconeumonía fibrinosa con múltiples focos de necrosis pulmonar y pleuritis fibrinosa. Se aisló Mycoplasma spp. de la glándula mamaria. Mediante nested-PCR, se detectó ADN de Mycoplasma spp. en glándula mamaria y pulmón. Mediante secuenciación se confirmó la presencia de Mycoplasma arginini y Mycoplasma bovis en la glándula mamaria y pulmón, respectivamente. Los hallazgos patológicos fueron similares a los descriptos en casos de agalactia contagiosa, por lo que fue necesario determinar que especies de Mycoplasma estaban presentes para poder descartar la presencia de esta enfermedad exótica. ARK-CAICYT: http://id.caicyt.gov.ar/ark:/s26182734/1ubkjvre0

Published
2022

3. The Impact of Surgical Practice on Oncological Outcomes in Robot-Assisted Radical Hysterectomy for Early-Stage Cervical Cancer, Spanish National Registry

Author

Sergi Fernandez-Gonzalez, Jordi Ponce, María Ángeles Martínez-Maestre, Marc Barahona, Natalia R. Gómez-Hidalgo, Berta Díaz-Feijoo, Andrea Casajuana, Myriam Gracia, Jon Frias-Gomez, Yolanda Benavente, Laura Costas, Lola Martí, Lidia Melero, Jose Manuel Silvan, Eva Beiro, Ignacio Lobo, Jesús De la Rosa, Pluvio J. Coronado, and Antonio Gil-Moreno

Subjects
Cancer Research, recurrence, Oncologia, oncological outcome, disease-free survival, surgical practice, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Càncer ginecològic, Cirurgia ginecològica, Gynecologic surgery, Oncología, surgery, Oncology, radical hysterectomy, robotic surgery, early-stage cervical cancer, Gynecologic cancer, RC254-282
Abstract

Minimal invasive surgery (MIS) has been associated with lower disease-free survival than open surgery among women who underwent radical hysterectomy for early-stage cervical cancer. However, the mechanisms by which MIS increases mortality in cervical cancer remain uncertain. We aimed to determine if surgical practice among centers using robotic surgery has an impact on oncological outcomes. We evaluated 215 women with early-stage cervical cancer (≤IB1 or IIA1, FIGO 2009) who underwent robot-assisted radical hysterectomy in five Spanish tertiary centers between 2009 and 2018. A higher surgical volume, higher participation in clinical trials, higher rate of MRI use for diagnosis, greater use of sentinel lymph node biopsies, and a favorable learning curve with low rates of early recurrences were observed for the centers with better oncological outcomes. These factors might have a significant impact on oncological outcomes in all surgical approaches. Abstract: This study aimed to assess whether surgical practice had a significant impact on oncological outcomes among women who underwent robot-assisted radical hysterectomy for early-stage cervical cancer (≤IB1 or IIA1, FIGO 2009). The secondary objective was to audit the pre-surgical quality indicators (QI) proposed by the European Society of Gynaecological Oncology (ESGO). The top 5 of 10 centers in Spain and Portugal were included in the analysis. The hospitals were divided into group A (n = 118) and group B (n = 97), with recurrence rates of 10%, respectively. After balancing both groups using the propensity score, the ORs for all events were higher and statistically significant for group B (recurrences OR = 1.23, 95% CI = 1.13-1.15, p-value = 0.001; death OR = 1.10, 95% CI = 1.02-1.18, p-value = 0.012; disease-specific mortality ORr = 1.11, 95% CI = 1.04-1.19, p-value = 0.002). A higher surgical volume, higher participation in clinical trials, higher rate of MRI use for diagnosis, greater use of sentinel lymph node biopsies, and a favorable learning curve with low rates of early recurrences were observed among the centers with better oncological outcomes. These factors might have a significant impact on oncological outcomes not only after robot-assisted surgery, but also after laparoscopies and open surgeries in the treatment of cervical cancer.

Published
2022

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