1. Specific behavioural phenotype and secondary cognitive decline as a result of an 8.6 Mb deletion of 2q32.2q33.1.
- Author
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Gregoric Kumperscak H, Krgovic D, and Vokac NK
- Subjects
- Abnormalities, Multiple diagnosis, Abnormalities, Multiple physiopathology, Adult, Chromosome Breakpoints, Chromosome Deletion, Chromosomes, Human, Pair 2 genetics, Cognitive Dysfunction diagnosis, Cognitive Dysfunction physiopathology, Female, Glutaminase deficiency, Glutaminase genetics, Humans, Hysteria psychology, Intellectual Disability diagnosis, Intellectual Disability physiopathology, Karyotyping, Matrix Attachment Region Binding Proteins deficiency, Matrix Attachment Region Binding Proteins genetics, Membrane Proteins deficiency, Membrane Proteins genetics, Myosin Type I deficiency, Myosin Type I genetics, Neoplasm Proteins deficiency, Neoplasm Proteins genetics, Phenotype, Phosphoric Monoester Hydrolases deficiency, Phosphoric Monoester Hydrolases genetics, Self-Injurious Behavior psychology, Transcription Factors deficiency, Transcription Factors genetics, Abnormalities, Multiple genetics, Aggression psychology, Cognitive Dysfunction genetics, Hysteria physiopathology, Intellectual Disability genetics, Self-Injurious Behavior physiopathology
- Abstract
Chromosomal abnormalities involving 2q32q33 deletions are very rare and present with a specific phenotype. This case report describes a 37-year-old female patient with 2q32q33 microdeletion syndrome presenting with the characteristic features, but with the addition of secondary cognitive decline. Molecular karyotyping was performed on the patient and her parents. It revealed an 8.6 megabase deletion with the proximal breakpoint in the chromosome band 2q32.2 and the distal breakpoint in 2q33.1. The deletion encompassed 22 known genes, including theGLS,MYO1B,TMEFF2,PGAP1andSATB2genes. The observed deletion was confirmed using a paralogue ratio test. This case report provides further evidence that theSATB2gene, together withGLS,MYO1B,TMEFF2and possiblyPGAP1,is a crucial gene in 2q32q33 microdeletion syndrome. TheSATB2gene seems to be crucial for the behavioural problems noted in our case, but deletion of theGLS,MYO1BandTMEFF2genes presumably contributed to the more complex behavioural characteristics observed. Our patient is also, to our knowledge, the only patient with 2q32q33 microdeletion syndrome with secondary cognitive decline., (© The Author(s) 2016.)
- Published
- 2016
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