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1. Impact of fibre and red/processed meat intake on treatment outcomes among patients with chronic inflammatory diseases initiating biological therapy: A prospective cohort study

Author

Overgaard, Silja H., primary, Sørensen, Signe B., additional, Munk, Heidi L., additional, Nexøe, Anders B., additional, Glerup, Henning, additional, Henriksen, Rikke H., additional, Guldmann, Tanja, additional, Pedersen, Natalia, additional, Saboori, Sanaz, additional, Hvid, Lone, additional, Dahlerup, Jens F., additional, Hvas, Christian L., additional, Jawhara, Mohamad, additional, Andersen, Karina W., additional, Pedersen, Andreas K., additional, Nielsen, Ole H., additional, Bergenheim, Fredrik, additional, Brodersen, Jacob B., additional, Heitmann, Berit L., additional, Halldorsson, Thorhallur I., additional, Holmskov, Uffe, additional, Bygum, Anette, additional, Christensen, Robin, additional, Kjeldsen, Jens, additional, Ellingsen, Torkell, additional, and Andersen, Vibeke, additional

Published
2022
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2. Impact of fibre and red/processed meat intake on treatment outcomes among patients with chronic inflammatory diseases initiating biological therapy:A prospective cohort study

Author

Overgaard, Silja H., Sørensen, Signe B., Munk, Heidi L., Nexøe, Anders B., Glerup, Henning, Henriksen, Rikke H., Guldmann, Tanja, Pedersen, Natalia, Saboori, Sanaz, Hvid, Lone, Dahlerup, Jens F., Hvas, Christian L., Jawhara, Mohamad, Andersen, Karina W., Pedersen, Andreas K., Nielsen, Ole H., Bergenheim, Fredrik, Brodersen, Jacob B., Heitmann, Berit L., Halldorsson, Thorhallur I., Holmskov, Uffe, Bygum, Anette, Christensen, Robin, Kjeldsen, Jens, Ellingsen, Torkell, Andersen, Vibeke, Overgaard, Silja H., Sørensen, Signe B., Munk, Heidi L., Nexøe, Anders B., Glerup, Henning, Henriksen, Rikke H., Guldmann, Tanja, Pedersen, Natalia, Saboori, Sanaz, Hvid, Lone, Dahlerup, Jens F., Hvas, Christian L., Jawhara, Mohamad, Andersen, Karina W., Pedersen, Andreas K., Nielsen, Ole H., Bergenheim, Fredrik, Brodersen, Jacob B., Heitmann, Berit L., Halldorsson, Thorhallur I., Holmskov, Uffe, Bygum, Anette, Christensen, Robin, Kjeldsen, Jens, Ellingsen, Torkell, and Andersen, Vibeke

Abstract

Background: Biologic disease-modifying drugs have revolutionised the treatment of a number of chronic inflammatory diseases (CID). However, up to 60% of the patients do not have a sufficient response to treatment and there is a need for optimization of treatment strategies. Objective: To investigate if the treatment outcome of biological therapy is associated with the habitual dietary intake of fibre and red/processed meat in patients with a CID. Methods: In this multicentre prospective cohort study, we consecutively enrolled 233 adult patients with a diagnosis of Crohn's Disease, Ulcerative Colitis, Rheumatoid Arthritis (RA), Axial Spondyloarthritis, Psoriatic Arthritis and Psoriasis, for whom biologic therapy was planned, over a 3 year period. Patients with completed baseline food frequency questionnaires were stratified into a high fibre/low red and processed meat exposed group (HFLM) and an unexposed group (low fibre/high red and processed meat intake = LFHM). The primary outcome was the proportion of patients with a clinical response to biologic therapy after 14–16 weeks of treatment. Results: Of the 193 patients included in our primary analysis, 114 (59%) had a clinical response to biologic therapy. In the HFLM group (N = 64), 41 (64%) patients responded to treatment compared to 73 (56%) in the LFHM group (N = 129), but the difference was not statistically significant (OR: 1.48, 0.72–3.05). For RA patients however, HFLM diet was associated with a more likely clinical response (82% vs. 35%; OR: 9.84, 1.35–71.56). Conclusion: Habitual HFLM intake did not affect the clinical response to biological treatment across CIDs. HFLM diet in RA patients might be associated with better odds for responding to biological treatment, but this would need confirmation in a randomised trial. Trial registration: (clinicaltrials.gov), identifier [NCT03173144].

Published
2022

3. Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases:protocol for a prospective cohort study of prognostic factors and personalised medicine

Author

Christensen, Robin, Heitmann, Berit L., Andersen, Karina Winther, Nielsen, Ole Haagen, Sørensen, Signe Bek, Jawhara, Mohamad, Bygum, Anette, Hvid, Lone, Grauslund, Jakob, Wied, Jimmi, Glerup, Henning, Fredberg, Ulrich, Villadsen, Jan Alexander, Kjær, Søren Geill, Fallingborg, Jan, Moghadd, Seyed A. G. R., Knudsen, Torben, Brodersen, Jacob, Frøjk, Jesper, Dahlerup, Jens Frederik, Bojesen, Anders Bo, Sørensen, Grith Lykke, Thiel, Steffen, Færgeman, Nils J., Brandslund, Ivan, Bennike, Tue Bjerg, Stensballe, Allan, Schmidt, Erik Berg, Franke, Andre, Ellinghaus, David, Rosenstiel, Philip, Raes, Jeroen, Boye, Mette, Werner, Lars, Nielsen, Charlotte Lindgaard, Munk, Heidi Lausten, Nexoe, Anders Bathum, Ellingsen, Torkell, Holmskov, Uffe, Kjeldsen, Jens, Andersen, Vibeke, Christensen, Robin, Heitmann, Berit L., Andersen, Karina Winther, Nielsen, Ole Haagen, Sørensen, Signe Bek, Jawhara, Mohamad, Bygum, Anette, Hvid, Lone, Grauslund, Jakob, Wied, Jimmi, Glerup, Henning, Fredberg, Ulrich, Villadsen, Jan Alexander, Kjær, Søren Geill, Fallingborg, Jan, Moghadd, Seyed A. G. R., Knudsen, Torben, Brodersen, Jacob, Frøjk, Jesper, Dahlerup, Jens Frederik, Bojesen, Anders Bo, Sørensen, Grith Lykke, Thiel, Steffen, Færgeman, Nils J., Brandslund, Ivan, Bennike, Tue Bjerg, Stensballe, Allan, Schmidt, Erik Berg, Franke, Andre, Ellinghaus, David, Rosenstiel, Philip, Raes, Jeroen, Boye, Mette, Werner, Lars, Nielsen, Charlotte Lindgaard, Munk, Heidi Lausten, Nexoe, Anders Bathum, Ellingsen, Torkell, Holmskov, Uffe, Kjeldsen, Jens, and Andersen, Vibeke

Published
2018

4. Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases: protocol for a prospective cohort study of prognostic factors and personalised medicine

Author

Christensen, Robin, primary, Heitmann, Berit L, additional, Andersen, Karina Winther, additional, Nielsen, Ole Haagen, additional, Sørensen, Signe Bek, additional, Jawhara, Mohamad, additional, Bygum, Anette, additional, Hvid, Lone, additional, Grauslund, Jakob, additional, Wied, Jimmi, additional, Glerup, Henning, additional, Fredberg, Ulrich, additional, Villadsen, Jan Alexander, additional, Kjær, Søren Geill, additional, Fallingborg, Jan, additional, Moghadd, Seyed A G R, additional, Knudsen, Torben, additional, Brodersen, Jacob, additional, Frøjk, Jesper, additional, Dahlerup, Jens Frederik, additional, Bojesen, Anders Bo, additional, Sorensen, Grith Lykke, additional, Thiel, Steffen, additional, Færgeman, Nils J, additional, Brandslund, Ivan, additional, Bennike, Tue Bjerg, additional, Stensballe, Allan, additional, Schmidt, Erik Berg, additional, Franke, Andre, additional, Ellinghaus, David, additional, Rosenstiel, Philip, additional, Raes, Jeroen, additional, Boye, Mette, additional, Werner, Lars, additional, Nielsen, Charlotte Lindgaard, additional, Munk, Heidi Lausten, additional, Nexøe, Anders Bathum, additional, Ellingsen, Torkell, additional, Holmskov, Uffe, additional, Kjeldsen, Jens, additional, and Andersen, Vibeke, additional

Published
2018
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5. A proposal for a study on treatment selection and lifestyle recommendations in chronic inflammatory diseases:A danish multidisciplinary collaboration on prognostic factors and personalised medicine

Author

Andersen, Vibeke, Holmskov, Uffe, Bek Sørensen, Signe, Jawhara, Mohamad, Andersen, Karina W., Bygum, Anette, Hvid, Lone, Grauslund, Jakob, Wied, Jimmi, Glerup, Henning, Fredberg, Ulrich, Villadsen, Jan Alexander, Kjær, Søren Geill, Fallingborg, Jan, Moghadd, Seyed A.G.R., Knudsen, Torben, Brodersen, Jacob, Frøjk, Jesper, Dahlerup, Jens F., Nielsen, Ole Haagen, Christensen, Robin, Bo Bojesen, Anders, Sorensen, Grith Lykke, Thiel, Steffen, Færgeman, Nils J., Brandslund, Ivan, Stensballe, Allan, Schmidt, Erik Berg, Franke, Andre, Ellinghaus, David, Rosenstiel, Philip, Raes, Jeroen, Heitmann, Berit, Boye, Mette, Nielsen, Charlotte Lindgaard, Werner, Lars, Kjeldsen, Jens, Ellingsen, Torkell, Andersen, Vibeke, Holmskov, Uffe, Bek Sørensen, Signe, Jawhara, Mohamad, Andersen, Karina W., Bygum, Anette, Hvid, Lone, Grauslund, Jakob, Wied, Jimmi, Glerup, Henning, Fredberg, Ulrich, Villadsen, Jan Alexander, Kjær, Søren Geill, Fallingborg, Jan, Moghadd, Seyed A.G.R., Knudsen, Torben, Brodersen, Jacob, Frøjk, Jesper, Dahlerup, Jens F., Nielsen, Ole Haagen, Christensen, Robin, Bo Bojesen, Anders, Sorensen, Grith Lykke, Thiel, Steffen, Færgeman, Nils J., Brandslund, Ivan, Stensballe, Allan, Schmidt, Erik Berg, Franke, Andre, Ellinghaus, David, Rosenstiel, Philip, Raes, Jeroen, Heitmann, Berit, Boye, Mette, Nielsen, Charlotte Lindgaard, Werner, Lars, Kjeldsen, Jens, and Ellingsen, Torkell

Abstract

Chronic inflammatory diseases (CIDs), including Crohn’s disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome.

Published
2017

6. A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine

Author

Andersen, Vibeke, primary, Holmskov, Uffe, additional, Sørensen, Signe, additional, Jawhara, Mohamad, additional, Andersen, Karina, additional, Bygum, Anette, additional, Hvid, Lone, additional, Grauslund, Jakob, additional, Wied, Jimmi, additional, Glerup, Henning, additional, Fredberg, Ulrich, additional, Villadsen, Jan, additional, Kjær, Søren, additional, Fallingborg, Jan, additional, Moghadd, Seyed, additional, Knudsen, Torben, additional, Brodersen, Jacob, additional, Frøjk, Jesper, additional, Dahlerup, Jens, additional, Nielsen, Ole, additional, Christensen, Robin, additional, Bojesen, Anders, additional, Sorensen, Grith, additional, Thiel, Steffen, additional, Færgeman, Nils, additional, Brandslund, Ivan, additional, Stensballe, Allan, additional, Schmidt, Erik, additional, Franke, Andre, additional, Ellinghaus, David, additional, Rosenstiel, Philip, additional, Raes, Jeroen, additional, Heitmann, Berit, additional, Boye, Mette, additional, Nielsen, Charlotte, additional, Werner, Lars, additional, Kjeldsen, Jens, additional, and Ellingsen, Torkell, additional

Published
2017
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7. Hvid, Lone

Author

Hvid, Lone and Hvid, Lone

Published
2010

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