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2. Patterns of health workforce turnover and retention in Aboriginal Community Controlled Health Services in remote communities of the Northern Territory and Western Australia, 2017–2019

Author

Veginadu, Prabhakar, Russell, Deborah J., Zhao, Yuejen, Guthridge, Steven, Ramjan, Mark, Jones, Michael P., Mathew, Supriya, Fitts, Michelle S., Murakami-Gold, Lorna, Campbell, Narelle, Tangey, Annie, Boffa, John, Rossingh, Bronwyn, Schultz, Rosalie, Humphreys, John, and Wakerman, John

Published
2024
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6. eQTLs identify regulatory networks and drivers of variation in the individual response to sepsis

Author

Addison, Jenni, Galley, Helen, Hall, Sally, Roughton, Sian, Taylor, Jane, Tennant, Heather, Webster, Nigel, Guleri, Achyut, Waddington, Natalia, Arawwawala, Dilshan, Durcan, John, Mitchell-Inwang, Christine, Short, Alasdair, Smolen, Susan, Swan, Karen, Williams, Sarah, Errington, Emily, Gordon, Tony, Templeton, Maie, McCauley, Marie, Venatesh, Pyda, Ward, Geraldine, Baudouin, Simon, Grier, Sally, Hall, Elaine, Higham, Charley, Soar, Jasmeet, Brett, Stephen, Kitson, David, Moreno, Juan, Mountford, Laura, Wilson, Robert, Hall, Peter, Hewlett, Jackie, McKechnie, Stuart, Faras-Arraya, Roser, Garrard, Christopher, Hutton, Paula, Millo, Julian, Parsons, Penny, Smiths, Alex, Young, Duncan, Raymode, Parizade, Andreou, Prem, Bowrey, Sarah, Hales, Dawn, Kazembe, Sandra, Rich, Natalie, Roberts, Emma, Thompson, Jonathan, Fletcher, Simon, Glister, Georgina, Rosbergen, Melissa, Cuesta, Jeronimo Moreno, Bion, Julian, Carrera, Ronald, Lees, Sarah, Millar, Joanne, Mitchell, Natalie, Nilson, Annette, Perry, Elsa Jane, Ruel, Sebastian, Wilde, Jude, Willis, Heather, Atkinson, Jane, Brown, Abby, Jacques, Nicola, Kapila, Atul, Prowse, Heather, Bland, Martin, Bullock, Lynne, Harrison, Donna, Krige, Anton, Mills, Gary, Humphreys, John, Armitage, Kelsey, Laha, Shond, Baldwin, Jacqueline, Walsh, Angela, Doherty, Nicola, Drage, Stephen, Ortiz-Ruiz de Gordoa, Laura, Lowes, Sarah, Walsh, Helen, Calder, Verity, Swan, Catherine, Payne, Heather, Higgins, David, Andrews, Sarah, Mappleback, Sarah, Hinds, Charles, Watson, D., McLees, Eleanor, Purdy, Alice, Stotz, Martin, Ochelli-Okpue, Adaeze, Bonner, Stephen, Whitehead, Iain, Hugil, Keith, Goodridge, Victoria, Cawthor, Louisa, Kuper, Martin, Pahary, Sheik, Bellingan, Geoffrey, Marshall, Richard, Montgomery, Hugh, Ryu, Jung Hyun, Bercades, Georgia, Boluda, Susan, Bentley, Andrew, Mccalman, Katie, Jefferies, Fiona, Allcock, Alice, Burnham, Katie, Davenport, Emma, Geoghegan, Cyndi, Knight, Julian, Maugeri, Narelle, Mi, Yuxin, Radhakrishnan, Jayachandran, Burnham, Katie L., Milind, Nikhil, Lee, Wanseon, Kwok, Andrew J., Cano-Gamez, Kiki, Geoghegan, Cyndi G., Zhang, Ping, Soranzo, Nicole, Hinds, Charles J., Knight, Julian C., and Davenport, Emma E.

Published
2024
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7. Evaluation of an open forecasting challenge to assess skill of West Nile virus neuroinvasive disease prediction

Author

Holcomb, Karen M., Mathis, Sarabeth, Staples, J. Erin, Fischer, Marc, Barker, Christopher M., Beard, Charles B., Nett, Randall J., Keyel, Alexander C., Marcantonio, Matteo, Childs, Marissa L., Gorris, Morgan E., Rochlin, Ilia, Hamins-Puértolas, Marco, Ray, Evan L., Uelmen, Johnny A., DeFelice, Nicholas, Freedman, Andrew S., Hollingsworth, Brandon D., Das, Praachi, Osthus, Dave, Humphreys, John M., Nova, Nicole, Mordecai, Erin A., Cohnstaedt, Lee W., Kirk, Devin, Kramer, Laura D., Harris, Mallory J., Kain, Morgan P., Reed, Emily M. X., and Johansson, Michael A.

Published
2023
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10. The development of water and oxygen tolerant catalysts for ammonia synthesis

Author

Humphreys, John

Subjects
546, QD Chemistry, TP Chemical technology
Abstract

Due to its essential use as a fertilizer, ammonia synthesis from nitrogen and hydrogen is considered to be one of the most important chemical processes of the last 100 years with the development of the high temperature and pressure Haber-Bosch process winning Fritz Haber and Carl Bosch the Nobel Prize in chemistry in 1918 and 1931 respectively. Since then an enormous amount of work has been undertaken in order to investigate and develop effective catalysts for this process. This has led to the discovery of various effective catalysts for the synthesis of ammonia, with high activities shown for iron, ruthenium and metal nitride catalysts. Although the catalytic synthesis of ammonia has been extensively studied in the last century, many new catalysts are still currently being developed in order to reduce the operating temperature and pressure of the process and to improve the conversion of reactants to ammonia. In this thesis, new promotor materials for ammonia synthesis catalysts have been developed. These promotor materials are BaZr0.1Ce0.7Y0.2O3, ZrO2/Zr, Ce0.8Sm0.2O2-δ, CeO2-xNy, and Ce0.5Sm0.5O2-xNy. Through catalytic activity measurements carried out at high temperature and pressure along with a range of characterisation techniques including; X-ray diffraction (XRD), Scanning electron microscopy (SEM), Element mapping (EDX), B.E.T. surface area analysis (B.E.T.), and X-ray florescence (XRF), the effect of properties including extrinsic oxygen vacancies and nitrogen content were analysed for their effect on the ammonia synthesis reaction. In our results it was found that the activity can be significantly increased by introducing these desirable properties in to the catalyst promotors. It was found that an increase from 9.7 mmol g-1 h-1 to 12.3 mmol g-1 h-1 can be achieved at 3 MPa and 450 oC when extrinsic oxygen vacancies are introduced to the CeO2 promotor through samarium doping. By introducing nitrogen in to the CeO2 promotor to create oxynitride material CeO2-xNy an increase in activity was seen at 450 oC and 3 MPa to a value of 17.2 mmol g-1 h-1. By introducing extrinsic oxygen vacancies in to the oxynitride material it was shown that an activity of 18.8 mmol g-1 h-1 can be achieved at a temperature of 400 oC and 3 MPa for the Ce0.5Sm0.5O2-xNy promoted Fe catalyst and an activity of 27.6 mmol g-1 h-1 at 400 oC and 3 MPa for the Ce0.5Sm0.5O2-xNy promoted Ru catalyst. From these results the potential to develop promising industrial catalysts for both current ammonia plants as well as small scale low carbon ammonia synthesis processes using renewable electricity can be seen whether using these material or new promotor materials exhibiting similar properties.

Published
2019

11. Modeling the 2014–2015 Vesicular Stomatitis Outbreak in the United States Using an SEIR-SEI Approach.

Author

Humphreys, John M., Pelzel-McCluskey, Angela M., Shults, Phillip T., Velazquez-Salinas, Lauro, Bertram, Miranda R., McGregor, Bethany L., Cohnstaedt, Lee W., Swanson, Dustin A., Scroggs, Stacey L. P., Fautt, Chad, Mooney, Amber, Peters, Debra P. C., and Rodriguez, Luis L.

Subjects
*VESICULAR stomatitis, *MARKOV chain Monte Carlo, *VECTOR-borne diseases, *INFECTIOUS disease transmission, *INSECT hosts
Abstract

Vesicular stomatitis (VS) is a vector-borne livestock disease caused by the vesicular stomatitis New Jersey virus (VSNJV). This study presents the first application of an SEIR-SEI compartmental model to analyze VSNJV transmission dynamics. Focusing on the 2014–2015 outbreak in the United States, the model integrates vertebrate hosts and insect vector demographics while accounting for heterogeneous competency within the populations and observation bias in documented disease cases. Key epidemiological parameters were estimated using Bayesian inference and Markov chain Monte Carlo (MCMC) methods, including the force of infection, effective reproduction number ( R t ), and incubation periods. The model revealed significant underreporting, with only 10–24% of infections documented, 23% of which presented with clinical symptoms. These findings underscore the importance of including competence and imperfect detection in disease models to depict outbreak dynamics and inform effective control strategies accurately. As a baseline model, this SEIR-SEI implementation is intended to serve as a foundation for future refinements and expansions to improve our understanding of VS dynamics. Enhanced surveillance and targeted interventions are recommended to manage future VS outbreaks. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Attitudes to Short-Term Staffing and Workforce Priorities of Community Users of Remote Aboriginal Community-Controlled Health Services: A Qualitative Study

Author

Liddle, Zania, primary, Fitts, Michelle S., additional, Bourke, Lisa, additional, Murakami-Gold, Lorna, additional, Campbell, Narelle, additional, Russell, Deborah J., additional, Mathew, Supriya, additional, Bonson, Jason, additional, Mulholland, Edward, additional, Humphreys, John S., additional, Zhao, Yuejen, additional, Boffa, John, additional, Ramjan, Mark, additional, Tangey, Annie, additional, Schultz, Rosalie, additional, and Wakerman, John, additional

Published
2024
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13. Reflection on the Development of a Research Agenda in Rural Health

Author

Bourke, Lisa, Best, James D., Wakerman, John, Humphreys, John S., and Wright, Julian R.

Abstract

There is a dearth of literature on how research agendas have been developed. In this article, the authors reflect on the process of developing a research agenda through a case study of a rural health university centre. The aim is to contribute to understanding how a team can effectively plan research. Two leaders of the process, as well as academics external to the process, reflected on the experience and the outcome of the agenda development process. Reflections focused on three areas: (a) engagement levels, (b) power and influence, and (c) interpretation of the research agenda. First, while there was passionate discussion at meetings and afterward, engagement levels varied. Second, the process was imbued with power and influence at multiple levels. Finally, the availability of a conceptual framework to contextualise rural and remote health research helped in interpreting the significance of the resulting research agenda. The article concludes with contrasting thoughts on the place of research agendas within contemporary neoliberal regimes of research management.

Published
2015

16. Interrogating Genomes and Geography to Unravel Multiyear Vesicular Stomatitis Epizootics.

Author

Humphreys, John M., Shults, Phillip T., Velazquez-Salinas, Lauro, Bertram, Miranda R., Pelzel-McCluskey, Angela M., Pauszek, Steven J., Peters, Debra P. C., and Rodriguez, Luis L.

Subjects
*VESICULAR stomatitis, *VIRAL variation, *VIRUS diversity, *VECTOR-borne diseases, *SUMMER
Abstract

We conducted an integrative analysis to elucidate the spatial epidemiological patterns of the Vesicular Stomatitis New Jersey virus (VSNJV) during the 2014–15 epizootic cycle in the United States (US). Using georeferenced VSNJV genomics data, confirmed vesicular stomatitis (VS) disease cases from surveillance, and a suite of environmental factors, our study assessed environmental and phylogenetic similarity to compare VS cases reported in 2014 and 2015. Despite uncertainties from incomplete virus sampling and cross-scale spatial processes, patterns suggested multiple independent re-invasion events concurrent with potential viral overwintering between sequential seasons. Our findings pointed to a geographically defined southern virus pool at the US–Mexico interface as the source of VSNJV invasions and overwintering sites. Phylodynamic analysis demonstrated an increase in virus diversity before a rise in case numbers and a pronounced reduction in virus diversity during the winter season, indicative of a genetic bottleneck and a significant narrowing of virus variation between the summer outbreak seasons. Environment–vector interactions underscored the central role of meta-population dynamics in driving disease spread. These insights emphasize the necessity for location- and time-specific management practices, including rapid response, movement restrictions, vector control, and other targeted interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Advancements in Green Ammonia Production and Utilisation Technologies.

Author

Humphreys, John and Shanwen Tao

Subjects
AMMONIA industry, ELECTROCHEMICAL analysis, RENEWABLE energy standards, ENERGY industries, HABER-Bosch process
Abstract

Green ammonia, produced through renewable energy-powered electrochemical and thermal processes, is emerging as a promising candidate to replace fossil fuel-based ammonia in the fertiliser, transportation and energy sectors. This paper provides an overview of the production methods, utilisation methods and technological advancements for green ammonia. The electrochemical production and Haber-Bosch with renewable hydrogen and energy are discussed in detail highlighting recent material advances. Green ammonia utilisation methods are discussed with direct use cases such as ammonia combustion and direct ammonia fuel cells examined. Green ammonia’s potential as a carbon-free hydrogen carrier is also discussed in regards to ammonia cracking for effective hydrogen recovery. This paper concludes that green ammonia has the potential to play a significant role in the transition to a sustainable energy system and offers new opportunities for the fertiliser, transportation and energy industries. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Hydrostatic Pressure Sensing by WNK kinases

Author

Humphreys, John M., primary, Teixeira, Liliana R., additional, Akella, Radha, additional, He, Haixia, additional, Kannangara, Ashari R., additional, Sekulski, Kamil, additional, Pleinis, John, additional, Liwocha, Joanna, additional, Jiou, Jenny, additional, Servage, Kelly A., additional, Orth, Kim, additional, Joachimiak, Lukasz, additional, Rizo, Josep, additional, Cobb, Melanie H., additional, Brautigam, Chad A., additional, Rodan, Aylin R., additional, and Goldsmith, Elizabeth J., additional

Published
2023
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29. Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening

Author

Chlebowicz,Julita, Akella,Radha, Humphreys,John M, He,Haixia, Kannangara,Ashari R, Wei,Shuguang, Posner,Bruce, Goldsmith,Elizabeth J, Chlebowicz,Julita, Akella,Radha, Humphreys,John M, He,Haixia, Kannangara,Ashari R, Wei,Shuguang, Posner,Bruce, and Goldsmith,Elizabeth J

Abstract

Julita Chlebowicz,1 Radha Akella,1 John M Humphreys,1 Haixia He,1 Ashari R Kannangara,1 Shuguang Wei,2 Bruce Posner,2 Elizabeth J Goldsmith1 1Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USACorrespondence: Elizabeth J Goldsmith, Department of Biophysics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-8816, USA, Tel +1 214 645 6376, Email Elizabeth.goldsmith@utsouthwestern.eduIntroduction: WNK [with no lysine (K)] kinases are serine/threonine kinases associated with familial hyperkalemic hypertension (FHHt). WNKs are therapeutic targets for blood pressure regulation, stroke and several cancers including triple negative breast cancer and glioblastoma. Here, we searched for and characterized novel WNK kinase inhibitors.Methods: We used a ~210,000-compound library in a high-throughput screen, re-acquisition and assay, commercial specificity screens and crystallography to identify WNK-isoform-selective inhibitors.Results: We identified five classes of compounds that inhibit the kinase activity of WNK1: quinoline compounds, halo-sulfones, cyclopropane-containing thiazoles, piperazine-containing compounds, and nitrophenol-derived compounds. The compounds are strongly pan-WNK selective, inhibiting all four WNK isoforms. A class of quinoline compounds was identified that further shows selectivity among the WNK isoforms, being more potent toward WNK3 than WNK1. The crystal structure of the quinoline-derived SW120619 bound to the kinase domain of WNK3 reveals active site binding, and comparison to the WNK1 structure reveals the potential origin of isoform specificity.Discussion: The newly discovered classes of compounds may be starting points for generating pharmacological tools and potential drugs treating hypertension and cancer.Keywords: WNK, inhibition screen, k

Published
2023

44. Carbon storage in UK intertidal environments

Author

Humphreys, John, Little, Sally, Austin, William E.N., Smeaton, Craig, Ruranska, Paulina, Paterson, David M., Skov, Martin W, Ladd, Cai J.T., McMahon, Lucy, Havelock, Glenn M., Gehrels, Roland, Mills, Rob, Barlow, Natasha L.M., Burden, Annette, Jones, Laurence, Garbutt, Angus, Humphreys, John, Little, Sally, Austin, William E.N., Smeaton, Craig, Ruranska, Paulina, Paterson, David M., Skov, Martin W, Ladd, Cai J.T., McMahon, Lucy, Havelock, Glenn M., Gehrels, Roland, Mills, Rob, Barlow, Natasha L.M., Burden, Annette, Jones, Laurence, and Garbutt, Angus

Abstract

We report on progress to assess carbon stocks in UK saltmarsh habitats, highlighting best practice in achieving national-scale assessments, including advances in field, laboratory and data methods. New understanding of coring disturbance highlights sediment compaction and its influence on carbon stock assessment; improvements in remote sensing methods are outlined and approaches to upscaling for carbon stock assessment are described. Here, we introduce the first UK-specific saltmarsh conversion for loss-on-ignition estimates of soil organic matter to soil organic carbon. The underlying drivers that determine the spatial distribution, magnitude and future vulnerability of these important natural capital assets are assessed, highlighting the significance of long-term sea-level drivers in shaping UK coastal environments and carbon stocks. The potential for management interventions that safeguard these long-term carbon stores through the protection, restoration and creation of saltmarsh habitats are also assessed. We highlight the emergent national policy opportunities for the inclusion of saltmarsh habitats in the UK greenhouse gas inventory, providing an important first step necessary to account for, protect and restore these long-term carbon stores, realising their potential for climate change mitigation.

Published
2022

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