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We propose multicavity reflective Gires-Tournois etalons (MCR-GTE) and generalized multicavity transmissive Gires-Tournois etalons (GMCT-GTE) composed of cascaded Sagnac loop mirrors and ring resonators, respectively. Michelson-Gires-Tournois interferometers (MGTI) based on two sets of MCR-GTEs are theoretically studied. As the focal point, we demonstrate the GMCT-GTE, which is a reciprocal and transmissive element as a tunable dispersion compensator (TDC) for the proposed interleaver. The reciprocal and transmissive TDC is superior to reflective ones in terms of saving the number of TDCs. Only one set of TDCs is sufficient for the two output ports of the MGTI proposed. Discussions on fabrication tolerances are given as well, focusing on two main factors that degrade the performance of the interleaver and its TDC in practice, i.e., the length mismatch and loss. OCIS codes: 060.1810, 120.2230, 120.2440, 130.2035, 130.3120.

A single-frequency Q-switched erbium-doped fiber ring laser is implemented for producing a single frequency with 25-Mhz laser linewidth, Q-switched pulses with a high peak power at 1557.5 nm. The single longitudinal mode is selected by a distributed Bragg reflector fiber laser, and a fiber-optic Mach-Zehnder interferometer acts as a Q-switch. The peak power and the average power of the Q-switched pulses vary with the repetition rate. OCIS codes: 140.0140, 140.3500, 140.3510, 140.3540, 060.2410.

Hydroxy-α-sanshool was synthesized in a 13% overall yield through eight steps, which included two Wittig reactions that were used to form the carbon skeleton with ethyl 2-oxoacetate and 2 E,4 E -hexadienal being reacted with the appropriate ylides. Impurities in the processes could easily be separated. Ethyl 6-hydroxy-2Z-hexenoate was converted to its E -isomer with catalysis by I2 and 2E,6Z,8E,10E-dodecatetraenoic acid was crystallized from a solution in 1% ethyl acetate in n -hexane. [ABSTRACT FROM AUTHOR]

Background: The prevalence of hypertension is high and increasing in China in recent years. The treatment and control of hypertension calls for long-term management beyond hospital, which is hard to implement in traditional care settings. Integrated care combined with information technology can promote high-quality healthcare services across the life-course. However, few studies have applied a customized integrated care model in community-based hypertension management in China, catering to the emerging "three-manager" mode. This study aims to identify the effectiveness of a pathway-driven eHealth-based integrated model that implemented as a full-featured telehealth system to facilitate standardized management of hypertension in China.Methods: The trial has been designed as a 1-year, non-blinded superiority trial with two parallel groups. A total of 402 hypertensive patients who meet the eligibility criteria will be recruited and randomized with a 1:1 allocation. All the participants will receive a mobile device for self-management, which is a part of our telehealth system. Participants in the control group will only use the device for BP measurement and receive regular follow-ups from care providers according to the guidelines. Participants in the intervention group will gain full access to the system and receive intervention based on the proposed model (a well-designed coordinated care pathway consisting of 9 tasks). Outcomes will be measured mainly on three occasions (at inclusion, at 6 months, and at 12 months). The primary outcome is mean change in systolic blood pressure over a 12-month period. Secondary outcomes include changes in diastolic blood pressure, biochemical indexes related to hypertension, lifestyles, self-management adherence, and hypertension awareness, as well as work efficiency of care providers.Discussion: This study aims to investigate whether a pathway-driven eHealth-based integrated care model based on the "three-manager" mode will improve hypertension control in China. Success of the model would help improve the quality of present community-based management procedures and benefit more patients with uncontrolled hypertension.Trial Registration: Chinese Clinical Trial Registry ChiCTR1900027645 . Registered on November 22, 2019. [ABSTRACT FROM AUTHOR]

We propose a simple and effective even-power fast algorithm to obtain scalable fringe precision in self-mixing interference. In this letter, the principle of the even-power fast algorithm is introduced in detail. The validity of the proposed algorithm is demonstrated by means of simulated signals and confirmed by experimental measurements at different vibration amplitudes. Without adding any additional optical elements in the optical path, theoretical analysis shows that the resolution of the fringe could be enhanced to ${{\lambda }}/{2^{{\text{n}} + 3}} \text(n\,= \,0,\,1,\,2,\,3\ldots). Experimental results show a fringe precision of \lambda /32 is achieved at a sampling rate of 50 KS/s. The influence factors are also discussed when the algorithm is applied in actual measurements. [ABSTRACT FROM PUBLISHER]

Rationale and Objectives: Magnetic resonance (MR) imaging has been widely used to detect bone marrow (BM) changes after radiotherapy. However, little information about the dynamic MR appearance of early radiation-induced BM injury is available. This experimental study was designed to determine the MR appearance of irradiated BM during the initial 4 weeks after irradiation. Materials and Methods: After focal BM irradiation (20 Gy, single dose, x-ray), 12 of 20 rabbits underwent serial MR studies weekly from days 7 to 28; eight rabbits were used for histologic investigation on days 7, 14, 21, and 28 after irradiation. Results: Under microscopy, early BM changes after irradiation consisted of sinusoid dilatation and congestion, followed by a progressive decrease in cellularity and later fat degeneration. All irradiated BM showed relative hyperintensity on short-inversion time inversion recovery (STIR) imaging from days 7 to 21 after irradiation and increased enhancement with gadolinium diethylenetriamine pentaacetic acid (DTPA) administration from days 7 to 28 after irradiation. However, on STIR imaging and gadolinium DTPA enhancement, the relative signal intensity of irradiated BM appeared to decline in a time-dependent way. On fast spin-echo (FSE) T1-weighted imaging, relative hyperintensity was detected in irradiated BM from day 21 after irradiation. On fat-suppressed FSE T1-weighted imaging, a slight increase in signal intensity was shown in some irradiated BM (in five of 12 rabbits) on day 7 after irradiation. Conclusion: STIR imaging was sensitive to early BM congestion and sinusoidal dilatation, spin-echo T1-weighted imaging was effective in detecting later fatty degeneration in irradiated BM, and gadolinium DTPA enhancement may contribute to the evaluation of BM vascular injury in response to irradiation. [Copyright &y& Elsevier]

Objectives: To investigate the value of CT radiomics combined with radiological features in predicting pathological grade of stage I invasive pulmonary adenocarcinoma (IPA) based on the International Association for the Study of Lung Cancer (IASLC) new grading system., Methods: The preoperative CT images and clinical information of 294 patients with stage I IPA were retrospectively analyzed (159 training set; 69 validation set; 66 test set). Referring to the IASLC new grading system, patients were divided into a low/intermediate-grade group and a high-grade group. Radiomic features were selected by using the least absolute shrinkage and selection operator (LASSO), the logistic regression (LR) classifier was used to establish radiomics model (RM), clinical-radiological features model (CRM) and combined rad-score with radiological features model (CRRM), and visualized CRRM by nomogram. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve and calibration curve were used to evaluate the performance and fitness of models., Results: In the training set, RM, CRM, and CRRM achieved AUCs of 0.825 [95% CI (0.735-0.916)], 0.849 [95% CI (0.772-0.925)], and 0.888 [95% CI (0.819-0.957)], respectively. For the validation set, the AUCs were 0.879 [95% CI (0.734-1.000)], 0.888 [95% CI (0.794-0.982)], and 0.922 [95% CI (0.835-1.000)], and for the test set, the AUCs were 0.814 [95% CI (0.674-0.954)], 0.849 [95% CI (0.750-0.948)], and 0.860 [95% CI (0.755-0.964)] for RM, CRM, and CRRM, respectively., Conclusion: All three models performed well in predicting pathological grade, especially the combined model, showing CT radiomics combined with radiological features had the potential to distinguish the pathological grade of early-stage IPA., Competing Interests: Author JC was employed by the company Bayer Healthcare. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Huang, Xue, Deng, Chen, Zou, Tan, Jiang and Huang.)