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Your search keyword '"Hou, Yunde"' showing total 17 results
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17 results on '"Hou, Yunde"'

1. Establishment and development of national community-based collaborative innovation demonstration areas to achieve the control target of hepatitis B in China

Author

Ruan, Bing, Yu, Zhixin, Yang, Shigui, Xu, Kaijin, Ren, Jingjing, Yao, Jun, Wu, Nanping, Yu, Chengbo, Deng, Min, Xie, Tiansheng, Chen, Ping, Wang, Chencheng, Li, Yiping, Zhao, Yanhong, Sheng, Jifang, Hou, Yunde, Wu, Zunyou, Jin, Shuigao, Chen, Yude, Li, Mengfeng, Zhu, Fengcai, Tang, Hong, Hao, Yuantao, Pang, Xinghuo, Lu, Lin, Yang, Wen, Yuan, Zhengan, Xu, Aiqiang, Li, Zizhao, Ni, Mingjian, Yan, Yongping, Zhong, Qiu, Zhou, Lin, Li, Guojian, Meng, Qun, Hu, Jianping, Zhou, Hong, Zhang, Guangyu, Li, Dexin, Jiang, Wei, Li, Qing, Wu, Peixin, Xing, Ruoqi, Gu, Jinhui, Gao, Di, and Li, Lanjuan

Published
2019
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12. Replication and transcriptionomic analysis of human noroviruses in human intestinal enteroids

Author

Lin, Lin, Han, Jiagang, Yan, Tingbin, Li, Lili, Li, Jinsong, Ao, Yuanyun, Duan, Zhaojun, and Hou, Yunde

Subjects
Original Article
Abstract

Human noroviruses (HuNoVs) are a major cause of epidemic and sporadic cases of acute gastroenteritis worldwide. Recently, human intestinal enteroids (HIEs) have been shown to support the replication of HuNoVs, and be an excellent model to study HuNoV-host interactions. We implemented the HIE system in our laboratory and investigated the global molecular events associated with the mechanism of HuNoV-host interactions. Successful replication was observed for several norovirus GII genotypes, and totally 5,376 genes with different expression in HIEs were identified during infection. Bioinformatics analysis revealed that several important pathways, especially the "Signal transduction" and "Immune system" pathways, were involved in the HuNoV-host interaction. Quantitative PCR results validated that IFN-λ instead of IFN-β was elevated in HIEs after infection. Our study showed the holistic understanding of the transcriptome events in the HIE model infected by HuNoVs, and highlighted the important role of IFN-λ signaling in the HuNoV-host interactions.

Published
2019

13. Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery

Author

Yang, Fan, Yang, Jian, Zhang, Xiaobing, Chen, Lihong, Jiang, Yan, Yan, Yongliang, Tang, Xudong, Wang, Jing, Xiong, Zhaohui, Dong, Jie, Xue, Ying, Zhu, Yafang, Xu, Xingye, Sun, Lilian, Chen, Shuxia, Nie, Huan, Peng, Junping, Xu, Jianguo, Wang, Yu, Yuan, Zhenghong, Wen, Yumei, Yao, Zhijian, Shen, Yan, Qiang, Boqin, Hou, Yunde, Yu, Jun, and Jin, Qi

Published
2005

15. Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157

Author

Jin, Qi, Yuan, Zhenghong, Xu, Jianguo, Wang, Yu, Shen, Yan, Lu, Weichuan, Wang, Jinhua, Liu, Hong, Yang, Jian, Yang, Fan, Zhang, Xiaobing, Zhang, Jiyu, Yang, Guowei, Wu, Hongtao, Qu, Di, Dong, Jie, Sun, Lilian, Xue, Ying, Zhao, Ailan, Gao, Yishan, Zhu, Junping, Kan, Biao, Ding, Keyue, Chen, Shuxia, Cheng, Hongsong, Yao, Zhijian, He, Bingkun, Chen, Runsheng, Ma, Dalong, Qiang, Boqin, Wen, Yumei, Hou, Yunde, and Yu, Jun

Published
2002

17. Replication and transcriptionomic analysis of human noroviruses in human intestinal enteroids.

Author

Lin L, Han J, Yan T, Li L, Li J, Ao Y, Duan Z, and Hou Y

Abstract

Human noroviruses (HuNoVs) are a major cause of epidemic and sporadic cases of acute gastroenteritis worldwide. Recently, human intestinal enteroids (HIEs) have been shown to support the replication of HuNoVs, and be an excellent model to study HuNoV-host interactions. We implemented the HIE system in our laboratory and investigated the global molecular events associated with the mechanism of HuNoV-host interactions. Successful replication was observed for several norovirus GII genotypes, and totally 5,376 genes with different expression in HIEs were identified during infection. Bioinformatics analysis revealed that several important pathways, especially the "Signal transduction" and "Immune system" pathways, were involved in the HuNoV-host interaction. Quantitative PCR results validated that IFN-λ instead of IFN-β was elevated in HIEs after infection. Our study showed the holistic understanding of the transcriptome events in the HIE model infected by HuNoVs, and highlighted the important role of IFN-λ signaling in the HuNoV-host interactions., Competing Interests: None.

Published
2019

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