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1. Geophysical Observations of the 24 September 2023 OSIRIS-REx Sample Return Capsule Re-Entry

Author

Silber, Elizabeth A., Bowman, Daniel C., Carr, Chris G., Eisenberg, David P., Elbing, Brian R., Fernando, Benjamin, Garcés, Milton A., Haaser, Robert, Krishnamoorthy, Siddharth, Langston, Charles A., Nishikawa, Yasuhiro, Webster, Jeremy, Anderson, Jacob F., Arrowsmith, Stephen, Bazargan, Sonia, Beardslee, Luke, Beck, Brant, Bishop, Jordan W., Blom, Philip, Bracht, Grant, Chichester, David L., Christe, Anthony, Cummins, Kenneth, Cutts, James, Danielson, Lisa, Donahue, Carly, Eack, Kenneth, Fleigle, Michael, Fox, Douglas, Goel, Ashish, Green, David, Hasumi, Yuta, Hayward, Chris, Hicks, Dan, Hix, Jay, Horton, Stephen, Hough, Emalee, Huber, David P., Hunt, Madeline A., Inman, Jennifer, Islam, S. M. Ariful, Izraelevitz, Jacob, Jacob, Jamey D., Clarke, Jacob, Johnson, James, KC, Real J., Komjathy, Attila, Lam, Eric, LaPierre, Justin, Lewis, Kevin, Lewis, Richard D., Liu, Patrick, Martire, Léo, McCleary, Meaghan, McGhee, Elisa A., Mitra, Ipsita, Nag, Amitabh, Giraldo, Luis Ocampo, Pearson, Karen, Plaisir, Mathieu, Popenhagen, Sarah K., Rassoul, Hamid, Giannone, Miro Ronac, Samnani, Mirza, Schmerr, Nicholas, Spillman, Kate, Srinivas, Girish, Takazawa, Samuel K., Tempert, Alex, Turley, Reagan, Van Beek, Cory, Viens, Loïc, Walsh, Owen A., Weinstein, Nathan, White, Robert, Williams, Brian, Wilson, Trevor C., Wyckoff, Shirin, Yamamoto, Masa-yuki, Yap, Zachary, Yoshiyama, Tyler, and Zeiler, Cleat

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Geophysics
Abstract

Sample Return Capsules (SRCs) entering Earth's atmosphere at hypervelocity from interplanetary space are a valuable resource for studying meteor phenomena. The 24 September 2023 arrival of the OSIRIS-REx (Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer) SRC provided an unprecedented chance for geophysical observations of a well-characterized source with known parameters, including timing and trajectory. A collaborative effort involving researchers from 16 institutions executed a carefully planned geophysical observational campaign at strategically chosen locations, deploying over 400 ground-based sensors encompassing infrasound, seismic, distributed acoustic sensing (DAS), and GPS technologies. Additionally, balloons equipped with infrasound sensors were launched to capture signals at higher altitudes. This campaign (the largest of its kind so far) yielded a wealth of invaluable data anticipated to fuel scientific inquiry for years to come. The success of the observational campaign is evidenced by the near-universal detection of signals across instruments, both proximal and distal. This paper presents a comprehensive overview of the collective scientific effort, field deployment, and preliminary findings. The early findings have the potential to inform future space missions and terrestrial campaigns, contributing to our understanding of meteoroid interactions with planetary atmospheres. Furthermore, the dataset collected during this campaign will improve entry and propagation models as well as augment the study of atmospheric dynamics and shock phenomena generated by meteoroids and similar sources., Comment: 87 pages, 14 figures

Published
2024
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2. Factors XI and XII in extracorporeal membrane oxygenation: longitudinal profile in children

Author

Drop, Joppe, Letunica, Natasha, Van Den Helm, Suelyn, Heleen van Ommen, C., Wildschut, Enno, de Hoog, Matthijs, van Rosmalen, Joost, Barton, Rebecca, Yaw, Hui Ping, Newall, Fiona, Horton, Stephen B., Chiletti, Roberto, Johansen, Amy, Best, Derek, McKittrick, Joanne, Butt, Warwick, d’Udekem, Yves, MacLaren, Graeme, Linden, Matthew D., Ignjatovic, Vera, Attard, Chantal, and Monagle, Paul

Published
2023
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4. Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery: The NITRIC Randomized Clinical Trial

Author

Schlapbach, Luregn J, Gibbons, Kristen S, Horton, Stephen B, Johnson, Kerry, Long, Debbie A, Buckley, David H F, Erickson, Simon, Festa, Marino, d'Udekem, Yves, Alphonso, Nelson, Winlaw, David S, Delzoppo, Carmel, van Loon, Kim, Jones, Mark, Young, Paul J, Butt, Warwick, Schibler, Andreas, University of Zurich, and Butt, Warwick

Subjects
Heart Defects, Congenital, Male, Cardiopulmonary Bypass, Australia, Cardiac Output, Low, Infant, Newborn, Respiratory System Agents, Infant, 610 Medicine & health, General Medicine, Recovery of Function, Syndrome, 2700 General Medicine, Oxygenators, Nitric Oxide, Respiration, Artificial, Double-Blind Method, 10036 Medical Clinic, Humans, Female, Cardiac Surgical Procedures, Respiratory Insufficiency, Original Investigation, Netherlands, New Zealand
Abstract

IMPORTANCE: In children undergoing heart surgery, nitric oxide administered into the gas flow of the cardiopulmonary bypass oxygenator may reduce postoperative low cardiac output syndrome, leading to improved recovery and shorter duration of respiratory support. It remains uncertain whether nitric oxide administered into the cardiopulmonary bypass oxygenator improves ventilator-free days (days alive and free from mechanical ventilation). OBJECTIVE: To determine the effect of nitric oxide applied into the cardiopulmonary bypass oxygenator vs standard care on ventilator-free days in children undergoing surgery for congenital heart disease. DESIGN, SETTING, AND PARTICIPANTS: Double-blind, multicenter, randomized clinical trial in 6 pediatric cardiac surgical centers in Australia, New Zealand, and the Netherlands. A total of 1371 children younger than 2 years undergoing congenital heart surgery were randomized between July 2017 and April 2021, with 28-day follow-up of the last participant completed on May 24, 2021. INTERVENTIONS: Patients were assigned to receive nitric oxide at 20 ppm delivered into the cardiopulmonary bypass oxygenator (n = 679) or standard care cardiopulmonary bypass without nitric oxide (n = 685). MAIN OUTCOMES AND MEASURES: The primary end point was the number of ventilator-free days from commencement of bypass until day 28. There were 4 secondary end points including a composite of low cardiac output syndrome, extracorporeal life support, or death; length of stay in the intensive care unit; length of stay in the hospital; and postoperative troponin levels. RESULTS: Among 1371 patients who were randomized (mean [SD] age, 21.2 [23.5] weeks; 587 girls [42.8%]), 1364 (99.5%) completed the trial. The number of ventilator-free days did not differ significantly between the nitric oxide and standard care groups, with a median of 26.6 days (IQR, 24.4 to 27.4) vs 26.4 days (IQR, 24.0 to 27.2), respectively, for an absolute difference of −0.01 days (95% CI, −0.25 to 0.22; P = .92). A total of 22.5% of the nitric oxide group and 20.9% of the standard care group developed low cardiac output syndrome within 48 hours, needed extracorporeal support within 48 hours, or died by day 28, for an adjusted odds ratio of 1.12 (95% CI, 0.85 to 1.47). Other secondary outcomes were not significantly different between the groups. CONCLUSIONS AND RELEVANCE: In children younger than 2 years undergoing cardiopulmonary bypass surgery for congenital heart disease, the use of nitric oxide via cardiopulmonary bypass did not significantly affect the number of ventilator-free days. These findings do not support the use of nitric oxide delivered into the cardiopulmonary bypass oxygenator during heart surgery. TRIAL REGISTRATION: anzctr.org.au Identifier: ACTRN12617000821392

Published
2022

7. The Mw 5.1, 9 August 2020, Sparta Earthquake, North Carolina: The First Documented Seismic Surface Rupture in the Eastern United States

Author

Figueiredo, Paula, primary, Hill, Jesse, additional, Merschat, Arthur, additional, Scheip, Corey, additional, Stewart, Kevin, additional, Owen, Lewis, additional, Wooten, Richard, additional, Carter, Mark, additional, Szymanski, Eric, additional, Horton, Stephen, additional, Wegmann, Karl, additional, Bohnenstiehl, DelWayne, additional, Thompson, Gary, additional, Witt, Anne, additional, and Cattanach, Bart, additional

Published
2022
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9. A note on the credit crisis, time and social order

Author

Horton, Stephen

Subjects
Credit, Economics, Political science, Regional focus/area studies
Abstract

The materialisation of space-time is a central project for capitalism. Within the finance sector, the relationship between the (exchange) value of money now and the (capital) value of money in [...]

Published
2009

14. Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial

Author

Schlapbach, Luregn J, primary, Horton, Stephen Brian, additional, Long, Debbie Amanda, additional, Beca, John, additional, Erickson, Simon, additional, Festa, Marino, additional, d’Udekem, Yves, additional, Alphonso, Nelson, additional, Winlaw, David, additional, Johnson, Kerry, additional, Delzoppo, Carmel, additional, van Loon, Kim, additional, Gannon, B, additional, Fooken, Jonas, additional, Blumenthal, Antje, additional, Young, Paul, additional, Jones, Mark, additional, Butt, Warwick, additional, and Schibler, Andreas, additional

Published
2019
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17. 180 Ma continental drainage divide in northeastern Australia: Role of passive margin tectonics

Author

Nott, Jonathan and Horton, Stephen

Subjects
Drainage -- Environmental aspects, Continental margins -- Environmental aspects, Geology, Structural -- Environmental aspects, Erosion -- Environmental aspects, Topographic divides, Earth sciences
Abstract

The stratigraphy and sedimentology of Jurassic to Tertiary sediments within the Laura and Carpentaria basins in northeastern Australia show that the continental drainage divide here predates the onset of continental margin formation and has remained stationary since the Middle Jurassic. This result is contrary to models of the evolution of highlands adjacent to passive continental margins that state that divide migration associated with downwarping of the highland flank and widespread stream reversals and/or captures should occur following margin development. The results also show that a maximum of only 50 m of denudation could have occurred on the continental drainage divide here since the Cretaceous. Keywords: passive margin, tectonics, continental drainage divide, denudation.

Published
2000

25. Reply

Author

Karl, Tom R, primary and Horton, Stephen B, additional

Published
2000
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30. Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial.

Author

Gibbons KS, Schlapbach LJ, Horton SB, Long DA, Beca J, Erickson S, Festa M, d'Udekem Y, Alphonso N, Winlaw D, Johnson K, Delzoppo C, van Loon K, Gannon B, Fooken J, Blumenthal A, Young PJ, Butt W, and Schibler A

Abstract

Background: The NITric oxide during cardiopulmonary bypass (CPB) to improve Recovery in Infants with Congenital heart defects (NITRIC) trial, a 1320-patient, multicentre, randomised controlled trial, is aiming to improve survival free of ventilation after CPB by using nitric oxide delivered into the oxygenator of the CPB. Objective: To provide a statistical analysis plan before completion of patient recruitment and data monitoring. Final analyses for this study will adhere to this statistical analysis plan, which details all key pre-planned analyses. Stata scripts for analyses have been prepared alongside this statistical analysis plan. Methods: The statistical analysis plan was designed collaboratively by the chief investigators and trial statistician and builds on the previously published study protocol. All authors remain blinded to treatment allocation. Detail is provided on statistical analyses including cohort description, analysis of primary and secondary outcomes and adverse events. Statistical methods to compare outcomes are planned in detail to ensure methods are verifiable and reproducible. Results: The statistical analysis plan developed provides the trial outline, list of mock tables, and analysis scripts. The plan describes statistical analyses on cohort and baseline description, primary and secondary outcome analyses, process of care measures, physiological descriptors, and safety and adverse event reporting. We define the pre-specified subgroup analyses and the respective statistical tests used to compare subgroups. Conclusion: The statistical analysis plan for the NITRIC trial establishes detailed pre-planned analyses alongside Stata scripts to analyse the largest trial in the field of neonatal and paediatric heart surgery. The plan ensures standards for trial analysis validity aiming to minimise bias of analyses. Trial registration: ACTRN12617000821392., Competing Interests: Yves d’Udekem receives consultancy fees from Actelion (Janssen) and travel fees from Berlin Heart., (© 2021 College of Intensive Care Medicine of Australia and New Zealand.)

Published
2023
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