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9. Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States

Author

Steinau, Martin, Saraiya, Mona, Goodman, Marc T., Peters, Edward S., Watson, Meg, Cleveland, Jennifer L., Lynch, Charles F., Wilkinson, Edward J., Hernandez, Brenda Y., Copeland, Glen, Saber, Maria S., Hopenhayn, Claudia, Huang, Youjie, Cozen, Wendy, Lyu, Christopher, and Unger, Elizabeth R.

Subjects
Throat cancer -- Diagnosis -- Demographic aspects -- Prevention, Papillomavirus infections -- Research -- Demographic aspects -- Health aspects, Health
Abstract

Oropharyngeal cancers include malignancies that occur where the oral cavity and pharynx merge, including in the palatine and lingual tonsils, the posterior 1/3 (base) of the tongue, the soft palate, [...]

Published
2014
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10. Arsenic and Drinking Water

Author

Weinberg, Clarice, Hopenhayn, Claudia, Hertz-Picciotto, Irva, Browning, Steven R., and Huang, Bin

Published
2004

16. Prevalence of human papillomavirus types in invasive cervical cancers from seven US cancer registries prior to vaccine introduction

Author

Hopenhayn, Claudia, Christian, Amy, Christian, W. Jay, Watson, Meg, Unger, Elizabeth R., Lynch, Charles F., Peters, Edward S., Wilkinson, Edward J., Huang, Youjie, Copeland, Glenn, Cozen, Wendy, Saber, Maria Sibug, Goodman, Marc T., Hernandez, Brenda Y., Steinau, Martin, Lyu, Christopher, Tucker, Thomas T., and Saraiya, Mona

Subjects
Adult, Aged, 80 and over, Molecular Epidemiology, Adolescent, Genotype, Genotyping Techniques, Uterine Cervical Neoplasms, Middle Aged, Article, United States, Young Adult, Prevalence, Humans, Female, Registries, Papillomaviridae, Aged
Abstract

We conducted a baseline study of human papillomavirus (HPV) type prevalence in invasive cervical cancers (ICCs) using data from 7 cancer registries (CRs) in the United States. Cases were diagnosed between 1994 and 2005 before the implementation of the HPV vaccines.Cancer registries from Florida, Kentucky, Louisiana, Michigan, Hawaii, Iowa, and Los Angeles, California identified eligible ICC cases and obtained sections from representative blocks of archived tumor specimens for DNA extraction. All extracts were assayed by linear array and, if inadequate or HPV negative, retested with INNO-LiPA Genotype test. Clinical and demographic factors were obtained from the CRs and merged with the HPV typing data to analyze factors associated with different types and with HPV negativity.A total of 777 ICCs were included in this analysis, with broad geographic, age, and race distribution. Overall, HPV was detected in 91% of cases, including 51% HPV-16, 16% HPV-18 (HPV-16-negative), and 24% other oncogenic and rare types. After HPV-16 and -18, the most common types were 45, 33, 31, 35, and 52. Older age and nonsquamous histology were associated with HPV-negative typing.This study provides baseline prevaccine HPV types for postvaccine ICC surveillance in the future. HPV-16 and/or -18 were found in 67% of ICCs, indicating the potential for vaccines to prevent a significant number of cervical cancers.

Published
2014

17. Prevalence of Human Papillomavirus (HPV) Types in Invasive Vulvar Cancers and VIN3 in the United States Before Vaccine Introduction

Author

Gargano, Julia W., Wilkinson, Edward J., Unger, Elizabeth R., Steinau, Martin, Watson, Meg, Huang, Youjie, Copeland, Glenn, Cozen, Wendy, Goodman, Marc T., Hopenhayn, Claudia, Lynch, Charles F., Hernandez, Brenda Y., Peters, Edward S., Saber, Maria Sibug, Lyu, Christopher W., Sands, Lauren A., and Saraiya, Mona

Subjects
Adult, Aged, 80 and over, Viral Structural Proteins, Microscopy, Genotype, Vulvar Neoplasms, Histocytochemistry, Papillomavirus Infections, Middle Aged, Polymerase Chain Reaction, Article, United States, DNA, Viral, Prevalence, Humans, Female, Papillomaviridae, Carcinoma in Situ, Aged
Abstract

The study aimed to determine the baseline prevalence of human papillomavirus (HPV) types in invasive vulvar cancer (IVC) and vulvar intraepithelial neoplasia 3 (VIN 3) cases using data from 7 US cancer registries.Registries identified eligible cases diagnosed in 1994 to 2005 and requested pathology laboratories to prepare 1 representative block for HPV testing on those selected. Hematoxylin-eosin-stained sections preceding and following those used for extraction were reviewed to confirm representation. Human papillomavirus was detected using L1 consensus polymerase chain reaction (PCR) with PGMY9/11 primers and type-specific hybridization, with retesting of samples with negative and inadequate results with SPF10 primers. For IVC, the confirmatory hematoxylin-eosin slides were re-evaluated to determine histological type. Descriptive analyses were performed to examine distributions of HPV by histology and other factors.Human papillomavirus was detected in 121/176 (68.8%) cases of IVC and 66/68 (97.1%) cases of VIN 3 (p.0001). Patients with IVC and VIN 3 differed by median age (70 vs 55 y, p = .003). Human papillomavirus 16 was present in 48.6% of IVC cases and 80.9% of VIN 3 cases; other high-risk HPV was present in 19.2% of IVC cases and 13.2% of VIN 3 cases. Prevalence of HPV differed by squamous cell carcinoma histological subtype (p.0001) as follows: keratinizing, 49.1% (n = 55); nonkeratinizing, 85.7% (n = 14), basaloid, 92.3% (n = 14), warty 78.2% (n = 55), and mixed warty/basaloid, 100% (n = 7).Nearly all cases of VIN 3 and two thirds of IVC cases were positive for high-risk HPV. Prevalence of HPV ranged from 49.1% to 100% across squamous cell carcinoma histological subtypes. Given the high prevalence of HPV in IVC and VIN 3 cases, prophylactic vaccines have the potential to decrease the incidence of vulvar neoplasia.

Published
2012

18. Bladder cancer and mate consumption in Argentina: a case-control study

Author

Bates, Michael N., Hopenhayn, Claudia, Rey, Omar C., Moore, Lee E., Bates, Michael N., Hopenhayn, Claudia, Rey, Omar C., and Moore, Lee E.

Abstract

Mate is a 'tea', made from Ilex paraguariensis, widely consumed in South America, as mate con bombilla and mate cocido. Mate consumption has been associated with esophageal, oral, lung, and bladder cancers. This bladder cancer case-control study involved 114 Argentinean case-control pairs. Mate consumption was recorded for time of interview, and 20 and 40 years previously. Mate con bombilla consumed 20 years ago was associated with bladder cancer in ever-smokers (odds ratio=3.77, 95% confidence interval: 1.17-12.1), but not in never-smokers. Mate cocido was not associated with bladder cancer. These results are consistent with a previous study in Uruguay., Fil: Bates, Michael N. School of Public Health, University of California, Berkeley, CA 94720-7360, 140 Warren Hall, United States, Fil: Hopenhayn, Claudia. Cancer Control Program, School of Public Health, University of Kentucky, Lexington, KY, United States, Fil: Rey, Omar C. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina, Fil: Moore, Lee E. Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States

Published
2007

19. Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic

Author

Streinmaus, Craig, Moore, Lee E., Shipp, Miriam, Kalman, Dave, Rey, Omar A., Biggs, Mary Lou, Hopenhayn, Claudia, Bates, Michael N., Zheng, Schichun, Wiencke, John, Smith, Allan H., Streinmaus, Craig, Moore, Lee E., Shipp, Miriam, Kalman, Dave, Rey, Omar A., Biggs, Mary Lou, Hopenhayn, Claudia, Bates, Michael N., Zheng, Schichun, Wiencke, John, and Smith, Allan H.

Abstract

Methylation is the primary route of metabolism of inorganic arsenic in humans, and previous studies showed that interindividual differences in arsenic methylation may have important impacts on susceptibility to arsenic-induced cancer. To date, the factors that regulate arsenic methylation in humans are mostly unknown. Urinary arsenic methylation patterns and genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) were investigated in 170 subjects from an arsenic-exposed region in Argentina. Previous studies showed that subjects with the TT/AA polymorphisms at MTHFR 677 and 1298 have lower MTHFR activity than others. In this study, it was found that subjects with the TT/AA variant of MTHFR 677/1298 excreted a significantly higher proportion of ingested arsenic as inorganic arsenic and a lower proportion as dimethylarsinic acid. Women with the null genotype of GSTM1 excreted a significantly higher proportion of arsenic as monomethylarsonate than women with the active genotype. No associations were seen between polymorphisms in GSTT1 and arsenic methylation. This is the first study to report (1) associations between MTHFR and arsenic metabolism in humans, and (2) gender differences between genetic polymorphisms and urinary arsenic methylation patterns. Overall, this study provides evidence that MTHFR and GSTM1 are involved in arsenic metabolism in humans, and polymorphisms in the genes that encode these enzymes may play a role in susceptibility to arsenic-induced cancer., Fil: Streinmaus, Craig. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States, Fil: Moore, Lee E. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States, Fil: Shipp, Miriam. Occupational and Environmental Medicine, University of California, San Francisco, CA, United States, Fil: Kalman, Dave. School of Public Health and Community Medicine, University of Washington, Seattle, WA, United States, Fil: Rey, Omar A. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina, Fil: Biggs, Mary Lou. Fred Hutchinson Cancer Research Center, Seattle, WA, United States, Fil: Hopenhayn, Claudia. College of Public Health, University of Kentucky, Lexington, KY, United States, Fil: Bates, Michael N. School of Public Health, University of California, Berkeley, CA, United States, Fil: Zheng, Schichun. Department of Neurological Surgery, University of California, San Francisco, CA, United States, Fil: Wiencke, John. Department of Neurological Surgery, University of California, San Francisco, CA, United States, Fil: Smith, Allan H. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States

Published
2007

20. Abstract 1871: Ecological association of trace element exposure and lung and colorectal cancer incidence in Southeastern Kentucky

Author

Shelton, Brent J., primary, Johnson, Nancy, additional, Tucker, Thomas, additional, Li, Li, additional, Unrine, Jason, additional, Christian, Jay, additional, Huang, Bin, additional, Arnold, Susanne, additional, Hopenhayn, Claudia, additional, Chen, Li, additional, Sanderson, Wayne, additional, and Shi, Xianglin, additional

Published
2011
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22. Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based United States population.

Author

Hernandez, Brenda Y., Goodman, Marc T., Unger, Elizabeth R., Steinau, Martin, Powers, Amy, Lynch, Charles F., Cozen, Wendy, Saber, Maria Sibug, Peters, Edward S., Wilkinson, Edward J., Copeland, Glenn, Hopenhayn, Claudia, Huang, Youjie, Watson, Meg, Altekruse, Sean F., Lyu, Christopher, and Saraiya, Mona

Subjects
PENILE cancer, ETIOLOGY of cancer, BIOLOGICAL assay research, CARCINOGENESIS, DISEASE prevalence
Abstract

Background: Human papillomavirus (HPV) is estimated to play an etiologic role in 40-50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited. Methods: HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998-2005 within the catchment areas of seven U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review. Results: HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral genotypes were detected. HPV 16, found in 46% (36/79) of all cases (72% of HPVpositive cases) was the most prevalent genotype followed equally by HPV 18, 33, and 45, each of which comprised 5% of all cases. Multiple genotypeswere detected in 18% of viral positive cases. HPV prevalence did not significantly vary by age, race/ethnicity, population size of geographic region, cancer stage, histology, grade, penile subsite, or prior cancer history. Penile cases diagnosed in more recent years were more likely to be HPV-positive. Overall survival did not significantly vary by HPV status. Conclusion: The relatively high prevalence of HPV in our study population provides limited evidence of a more prominent and, possibly, increasing role of infection in penile carcinogenesis in the U.S. compared to other parts of the world. [ABSTRACT FROM AUTHOR]

Published
2014
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